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Protein

TPR and ankyrin repeat-containing protein 1

Gene

TRANK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TPR and ankyrin repeat-containing protein 1
Alternative name(s):
Lupus brain antigen 1 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRANK1
Synonyms:KIAA0342, LBA1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000168016.13

Human Gene Nomenclature Database

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HGNCi
HGNC:29011 TRANK1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O15050

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9881

Open Targets

More...
OpenTargetsi
ENSG00000168016

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165698606

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TRANK1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003482381 – 2925TPR and ankyrin repeat-containing protein 1Add BLAST2925

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O15050

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O15050

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O15050

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O15050

PeptideAtlas

More...
PeptideAtlasi
O15050

PRoteomics IDEntifications database

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PRIDEi
O15050

ProteomicsDB human proteome resource

More...
ProteomicsDBi
48402

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O15050

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O15050

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000168016 Expressed in 147 organ(s), highest expression level in right hemisphere of cerebellum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O15050 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O15050 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA035508

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115212, 2 interactors

Protein interaction database and analysis system

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IntActi
O15050, 2 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O15050

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati15 – 48TPR 1Add BLAST34
Repeati50 – 82TPR 2Add BLAST33
Repeati168 – 198ANK 1Add BLAST31
Repeati203 – 232ANK 2Add BLAST30
Repeati240 – 276ANK 3Add BLAST37
Repeati463 – 492ANK 4Add BLAST30
Repeati497 – 518ANK 5Add BLAST22
Repeati546 – 575ANK 6Add BLAST30
Repeati1699 – 1732TPR 3Add BLAST34
Repeati1793 – 1826TPR 4Add BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2301 – 2330Sequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1076 – 1115Glu-richAdd BLAST40

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeat, Coiled coil, Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IJ97 Eukaryota
ENOG410XUX5 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153370

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000168939

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG108082

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O15050

Identification of Orthologs from Complete Genome Data

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OMAi
KDLDDSM

Database of Orthologous Groups

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OrthoDBi
5008at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O15050

TreeFam database of animal gene trees

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TreeFami
TF335821

Family and domain databases

Conserved Domains Database

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CDDi
cd00204 ANK, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.25.40.10, 1 hit
1.25.40.20, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR027417 P-loop_NTPase
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
IPR039904 TRANK1

The PANTHER Classification System

More...
PANTHERi
PTHR21529 PTHR21529, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00248 ANK, 4 hits
SM00028 TPR, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 2 hits
SSF48452 SSF48452, 1 hit
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50293 TPR_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

O15050-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWDPRAARVP PRDLAVLLCN KSNAFFSLGK WNEAFVAAKE CLQWDPTYVK
60 70 80 90 100
GYYRAGYSLL RLHQPYEAAR MFFEGLRLVQ RSQDQAPVAD FLVGVFTTMS
110 120 130 140 150
SDSIVLQSFL PCFDHIFTTG FPTEVWQSVI EKLAKKGLWH SFLLLSAKKD
160 170 180 190 200
RLPRNIHVPE LSLKSLFEKY VFIGLYEKME QVPKLVQWLI SIGASVETIG
210 220 230 240 250
PYPLHALMRL CIQARENHLF RWLMDHKPEW KGRINQKDGD GCTVLHVVAA
260 270 280 290 300
HSPGYLVKRQ TEDVQMLLRF GADPTLLDRQ SRSVVDVLKR NKNFKAIEKI
310 320 330 340 350
NSHLEKLATC SKDLSGFSNG DGPTSENDIF RKVLEQLVKY MNSGNRLLHK
360 370 380 390 400
NFLKQEVVQR FLRLLSTLQE IPPDLVCDIN QDCATTVFKF LLEKQRWPEV
410 420 430 440 450
LLLLTRKVSG EPPLGDCLIK DCNFSDLDIC TIIPHLSTWD QRKKQLLGCL
460 470 480 490 500
IDSGALPDGL QESQERPVVT CLKHEDFELA FLLLTKGADP RAISLTEGDT
510 520 530 540 550
PLHAALHIFL EIKADIGFSF LSHLLDLFWS NPTEFDYLNP NVQDSNGNTL
560 570 580 590 600
MHILFQKGML KRVKKLLDLL VKFDINFNLK NKEGKDARHR IKKNDSLLLA
610 620 630 640 650
WNKALMENRR RSRQDSAAHL GKLSKSTAPG HTSQLKSQGS FKSVPCGATA
660 670 680 690 700
RTLPEGSAVP DSWETLPGTQ VTRKEPGALR PCSLRDCLMQ DITVLIQQVE
710 720 730 740 750
VDPSFPEDCL QSSEPLEAGA GKEGKKDDKP TLGAGAPDCS EVGEGHAQVG
760 770 780 790 800
LGALQLVPDD NRGKEGNDDQ DDWSTQEIEA CLQDFDNMTW EIECTSEMLK
810 820 830 840 850
KLSSKVMTKV IKKKIILAIQ QLGNGEWTQG LQKRLKHLKG SIQLFEAKLD
860 870 880 890 900
KGARMLWELA IDFSPRCSEN PEKIIATEQN TCAMEKSGRI YTEIIRIWDI
910 920 930 940 950
VLDHCKLADS IKAICNAYNR GLSCVLRKKL KGINKGQVSA NMKIQKRIPR
960 970 980 990 1000
CYVEDTEAEK GREHVNPEYF PPASAVETEY NIMKFHSFST NMAFNILNDT
1010 1020 1030 1040 1050
TATVEYPFRV GELEYAVIDL NPRPLEPIIL IGRSGTGKTT CCLYRLWKKF
1060 1070 1080 1090 1100
HVYWEKAEQA GSPLLAKQVW LKRRLEVEPG KESPGGEEEE EEEDEEEEDS
1110 1120 1130 1140 1150
IEVETVESID EQEYEACAGG AGVEPAGDGQ AAEVCAPEHP HQLEHLHQIF
1160 1170 1180 1190 1200
VTKNHVLCQE VQRNFIELSK STKATSHYKP LDPNIHKLQD LRDENFPLFV
1210 1220 1230 1240 1250
TSKQLLLLLD ASLPKPFFLR NEDGSLKRTI IGWSAQEEST IPSWQEDEEE
1260 1270 1280 1290 1300
AEVDGDYSEE DKAVEMRTGD SDPRVYVTFE VFKNEIWPKM TKGRTAYNPA
1310 1320 1330 1340 1350
LIWKEIKSFL KGSFEALSCP HGRLTEEVYK KLGRKRCPNF KEDRSEIYSL
1360 1370 1380 1390 1400
FSLYQQIRSQ KGYFDEEDVL YNISRRLSKL RVLPWSIHEL YGDEIQDFTQ
1410 1420 1430 1440 1450
AELALLMKCI NDPNSMFLTG DTAQSIMKGV AFRFSDLRSL FHYASRNTID
1460 1470 1480 1490 1500
KQCAVRKPKK IHQLYQNYRS HSGILNLASG VVDLLQFYFP ESFDRLPRDS
1510 1520 1530 1540 1550
GLFDGPKPTV LESCSVSDLA ILLRGNKRKT QPIEFGAHQV ILVANETAKE
1560 1570 1580 1590 1600
KIPEELGLAL VLTIYEAKGL EFDDVLLYNF FTDSEAYKEW KIISSFTPTS
1610 1620 1630 1640 1650
TDSREENRPL VEVPLDKPGS SQGRSLMVNP EMYKLLNGEL KQLYTAITRA
1660 1670 1680 1690 1700
RVNLWIFDEN REKRAPAFKY FIRRDFVQVV KTDENKDFDD SMFVKTSTPA
1710 1720 1730 1740 1750
EWIAQGDYYA KHQCWKVAAK CYQKGGAFEK EKLALAHDTA LSMKSKKVSP
1760 1770 1780 1790 1800
KEKQLEYLEL AKTYLECKEP TLSLKCLSYA KEFQLSAQLC ERLGKIRDAA
1810 1820 1830 1840 1850
YFYKRSQCYK DAFRCFEQIQ EFDLALKMYC QEELFEEAAI AVEKYEEMLK
1860 1870 1880 1890 1900
TKTLPISKLS YSASQFYLEA AAKYLSANKM KEMMAVLSKL DIEDQLVFLK
1910 1920 1930 1940 1950
SRKRLAEAAD LLNREGRREE AALLMKQHGC LLEAARLTAD KDFQASCLLG
1960 1970 1980 1990 2000
AARLNVARDS DIEHTKDILR EALDICYQTG QLSGIAEAHF LQGVILRDFQ
2010 2020 2030 2040 2050
KLRDAFFKFD TLNHSAGVVE ALYEAASQCE AEPEKILGLA PGGLEILLSL
2060 2070 2080 2090 2100
VRALKRVTNN AEKEMVKSCF EFFGISQVDA KYCQIAQNDP GPILRIIFDL
2110 2120 2130 2140 2150
DLNLREKKTK DHFLIMTDQV KLALNKHLLG RLCQITRSLL GKTYRGVCMR
2160 2170 2180 2190 2200
FIVGLKCEDE NCEHFHRPLR RCEAKCLVQS KMNLVAINGL LLEAKKVFPK
2210 2220 2230 2240 2250
ILAEELKEID YILSTDMYGL CKSILDVLFP KHFHQRVLSE NPMACKEILK
2260 2270 2280 2290 2300
PNYKSFRFYR FALKEYIHFL FENESARNRR ESTDLWLSAM QAFLLSSNYP
2310 2320 2330 2340 2350
EEFEKLLHQE EDNYNRELKA LESEKDERGR GRGSRIKGIE GKFGMLAPNR
2360 2370 2380 2390 2400
DDENMDKTHL CFIRLLENCI DQFYVYRNPE DYKRLFFRFM NVLIKRCKEP
2410 2420 2430 2440 2450
LIPSIGNTVA LLEFQFIHCG VVLARLWKNV ILCLPKSYIA LLHYWEFLFS
2460 2470 2480 2490 2500
KKDKELGDVF SIIQEYKPKD VTRAIQDFRF HLSYLAKVLC GYENVNFNVL
2510 2520 2530 2540 2550
LDAFSEIDYV VSGEAERTLV LCLVMLVNAE EILQPYCKPL LYRHFREIES
2560 2570 2580 2590 2600
RLQLMSMDCP GQVPERLLKV VKRVLVAVNV KSVAEALQDL LFERDEEYLM
2610 2620 2630 2640 2650
DCDWRWDPVH TKGSIVRGLY YEEVRLNRLL CLDPVDYFAE PECEFGQDEM
2660 2670 2680 2690 2700
DELALEDRDH VLATILSQKQ RKASIQRKLR RACLVVSLCI SWRRRVGTQM
2710 2720 2730 2740 2750
ERVREEAREP RAGNFKKADV DRTQCDLCGV KFTRGPENYF SPSKAFEGAA
2760 2770 2780 2790 2800
SEVAVLSRAE LEREECQERN SESYEQHIHL EHHQRQQVAY QKYSEFFHEK
2810 2820 2830 2840 2850
VDPAIDEGKL VVQDIEQSVW IHSHVGSKEH SHMLQKVQEH IKRVSDMVED
2860 2870 2880 2890 2900
LYRRKAWAGA EEAMTRLVNI LILSVRDARD WLMKTETRLK KEGIVQEDDY
2910 2920
ENEVEDFGEL RPRRRSRKCG KQRKY
Length:2,925
Mass (Da):336,221
Last modified:September 2, 2008 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDE9E997035B98D1D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8YEM9A0A2R8YEM9_HUMAN
TPR and ankyrin repeat-containing p...
TRANK1
2,969Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y7N6A0A2R8Y7N6_HUMAN
TPR and ankyrin repeat-containing p...
TRANK1
941Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y890A0A2R8Y890_HUMAN
TPR and ankyrin repeat-containing p...
TRANK1
612Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A096LPF5A0A096LPF5_HUMAN
TPR and ankyrin repeat-containing p...
TRANK1
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y8A3A0A2R8Y8A3_HUMAN
TPR and ankyrin repeat-containing p...
TRANK1
1,629Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC04838 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1286I → V in BAC04838 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_061021153P → L. Corresponds to variant dbSNP:rs17201603Ensembl.1
Natural variantiVAR_046117703P → L. Corresponds to variant dbSNP:rs17201603Ensembl.1
Natural variantiVAR_0461181090E → G2 PublicationsCorresponds to variant dbSNP:rs11712950Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC097360 Genomic DNA No translation available.
AC105749 Genomic DNA No translation available.
AC011816 Genomic DNA No translation available.
AB002340 mRNA Translation: BAA20800.3
AK096678 mRNA Translation: BAC04838.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS46789.2

NCBI Reference Sequences

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RefSeqi
NP_055646.2, NM_014831.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.170999

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000429976; ENSP00000416168; ENSG00000168016

Database of genes from NCBI RefSeq genomes

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GeneIDi
9881

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9881

UCSC genome browser

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UCSCi
uc003cgj.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC097360 Genomic DNA No translation available.
AC105749 Genomic DNA No translation available.
AC011816 Genomic DNA No translation available.
AB002340 mRNA Translation: BAA20800.3
AK096678 mRNA Translation: BAC04838.1 Different initiation.
CCDSiCCDS46789.2
RefSeqiNP_055646.2, NM_014831.2
UniGeneiHs.170999

3D structure databases

ProteinModelPortaliO15050
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115212, 2 interactors
IntActiO15050, 2 interactors

PTM databases

iPTMnetiO15050
PhosphoSitePlusiO15050

Polymorphism and mutation databases

BioMutaiTRANK1

Proteomic databases

EPDiO15050
jPOSTiO15050
MaxQBiO15050
PaxDbiO15050
PeptideAtlasiO15050
PRIDEiO15050
ProteomicsDBi48402

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000429976; ENSP00000416168; ENSG00000168016
GeneIDi9881
KEGGihsa:9881
UCSCiuc003cgj.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9881
DisGeNETi9881
EuPathDBiHostDB:ENSG00000168016.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TRANK1

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0003166
HGNCiHGNC:29011 TRANK1
HPAiHPA035508
neXtProtiNX_O15050
OpenTargetsiENSG00000168016
PharmGKBiPA165698606

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJ97 Eukaryota
ENOG410XUX5 LUCA
GeneTreeiENSGT00940000153370
HOGENOMiHOG000168939
HOVERGENiHBG108082
InParanoidiO15050
OMAiKDLDDSM
OrthoDBi5008at2759
PhylomeDBiO15050
TreeFamiTF335821

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TRANK1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9881

Protein Ontology

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PROi
PR:O15050

Gene expression databases

BgeeiENSG00000168016 Expressed in 147 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiO15050 baseline and differential
GenevisibleiO15050 HS

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.10, 1 hit
1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR027417 P-loop_NTPase
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
IPR039904 TRANK1
PANTHERiPTHR21529 PTHR21529, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 4 hits
SM00028 TPR, 2 hits
SUPFAMiSSF48403 SSF48403, 2 hits
SSF48452 SSF48452, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50293 TPR_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRNK1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15050
Secondary accession number(s): Q8N8K0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: January 16, 2019
This is version 136 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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