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Protein

NEDD4-binding protein 3

Gene

N4BP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in axon and dendrite arborization during cranial nerve development. May also be important for neural crest migration and early development of other anterior structures including eye, brain and cranial cartilage.By similarity

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processNeurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
NEDD4-binding protein 3
Short name:
N4BP3
Gene namesi
Name:N4BP3
Synonyms:KIAA0341
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000145911.5
HGNCiHGNC:29852 N4BP3
neXtProtiNX_O15049

Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cytoplasmic vesicle

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000145911

Polymorphism and mutation databases

BioMutaiN4BP3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000966821 – 544NEDD4-binding protein 3Add BLAST544

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei176PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO15049
MaxQBiO15049
PaxDbiO15049
PeptideAtlasiO15049
PRIDEiO15049
ProteomicsDBi48401

PTM databases

iPTMnetiO15049
PhosphoSitePlusiO15049

Expressioni

Gene expression databases

BgeeiENSG00000145911
GenevisibleiO15049 HS

Organism-specific databases

HPAiHPA030972
HPA030973
HPA061387

Interactioni

Subunit structurei

Binds NEDD4 (PubMed:11717310). Interacts with 14-3-3 proteins (PubMed:15324660).2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi116755, 17 interactors
IntActiO15049, 28 interactors
MINTiO15049
STRINGi9606.ENSP00000274605

Structurei

3D structure databases

ProteinModelPortaliO15049
SMRiO15049
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili294 – 530Sequence analysisAdd BLAST237

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi242 – 247Poly-Pro6

Sequence similaritiesi

Belongs to the N4BP3 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IE8K Eukaryota
ENOG410XQRF LUCA
GeneTreeiENSGT00510000046769
HOGENOMiHOG000230889
HOVERGENiHBG052566
InParanoidiO15049
OMAiTTLYYRE
OrthoDBiEOG091G03L2
PhylomeDBiO15049
TreeFamiTF331420

Family and domain databases

InterProiView protein in InterPro
IPR033571 N4BP3
PANTHERiPTHR32274 PTHR32274, 1 hit

Sequencei

Sequence statusi: Complete.

O15049-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATAPGPAGI AMGSVGSLLE RQDFSPEELR AALAGSRGSR QPDGLLRKGL
60 70 80 90 100
GQREFLSYLH LPKKDSKSTK NTKRAPRNEP ADYATLYYRE HSRAGDFSKT
110 120 130 140 150
SLPERGRFDK CRIRPSVFKP TAGNGKGFLS MQSLASHKGQ KLWRSNGSLH
160 170 180 190 200
TLACHPPLSP GPRASQARAQ LLHALSLDEG GPEPEPSLSD SSSGGSFGRS
210 220 230 240 250
PGTGPSPFSS SLGHLNHLGG SLDRASQGPK EAGPPAVLSC LPEPPPPYEF
260 270 280 290 300
SCSSAEEMGA VLPETCEELK RGLGDEDGSN PFTQVLEERQ RLWLAELKRL
310 320 330 340 350
YVERLHEVTQ KAERSERNLQ LQLFMAQQEQ RRLRKELRAQ QGLAPEPRAP
360 370 380 390 400
GTLPEADPSA RPEEEARWEV CQKTAEISLL KQQLREAQAE LAQKLAEIFS
410 420 430 440 450
LKTQLRGSRA QAQAQDAELV RLREAVRSLQ EQAPREEAPG SCETDDCKSR
460 470 480 490 500
GLLGEAGGSE ARDSAEQLRA ELLQERLRGQ EQALRFEQER RTWQEEKERV
510 520 530 540
LRYQREIQGG YMDMYRRNQA LEQELRALRE PPTPWSPRLE SSKI
Length:544
Mass (Da):60,470
Last modified:April 17, 2007 - v3
Checksum:i40F2652D0848C27C
GO

Sequence cautioni

The sequence BAA20799 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC86891 differs from that shown. Intron retention.Curated
The sequence BAC86891 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAG58525 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29L → P in BAA20799 (PubMed:9205841).Curated1
Sequence conflicti163R → Q in AAH53323 (PubMed:15489334).Curated1
Sequence conflicti317R → H in BAC86891 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002339 mRNA Translation: BAA20799.1 Different initiation.
CH471165 Genomic DNA Translation: EAW53851.1
CH471165 Genomic DNA Translation: EAW53852.1
CH471165 Genomic DNA Translation: EAW53853.1
CH471165 Genomic DNA Translation: EAW53854.1
BC053323 mRNA Translation: AAH53323.2
AK127224 mRNA Translation: BAC86891.1 Sequence problems.
AK295663 mRNA Translation: BAG58525.1 Different initiation.
CCDSiCCDS34307.1
RefSeqiNP_055926.1, NM_015111.1
XP_006714897.1, XM_006714834.3
XP_011532775.1, XM_011534473.1
XP_011532776.1, XM_011534474.1
UniGeneiHs.101761

Genome annotation databases

EnsembliENST00000274605; ENSP00000274605; ENSG00000145911
GeneIDi23138
KEGGihsa:23138
UCSCiuc003mik.2 human

Similar proteinsi

Entry informationi

Entry nameiN4BP3_HUMAN
AccessioniPrimary (citable) accession number: O15049
Secondary accession number(s): B4DIL3
, D3DWP3, Q6ZSQ6, Q7Z6I3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: April 17, 2007
Last modified: July 18, 2018
This is version 127 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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