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Protein

U2 snRNP-associated SURP motif-containing protein

Gene

U2SURP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
U2 snRNP-associated SURP motif-containing protein
Alternative name(s):
140 kDa Ser/Arg-rich domain protein
U2-associated protein SR140
Gene namesi
Name:U2SURP
Synonyms:KIAA0332, SR140
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000163714.17
HGNCiHGNC:30855 U2SURP
MIMi617849 gene
neXtProtiNX_O15042

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23350
OpenTargetsiENSG00000163714

Polymorphism and mutation databases

BioMutaiU2SURP

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002800702 – 1029U2 snRNP-associated SURP motif-containing proteinAdd BLAST1028

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei67PhosphoserineCombined sources1
Cross-linki80Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki145Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki168Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei202PhosphoserineCombined sources1
Cross-linki208Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei236PhosphoserineCombined sources1
Modified residuei485PhosphoserineCombined sources1
Modified residuei719PhosphothreonineCombined sources1
Cross-linki748Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki749Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei760N6-acetyllysine; alternateCombined sources1
Cross-linki760Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei788PhosphoserineCombined sources1
Modified residuei800PhosphoserineCombined sources1
Modified residuei811PhosphoserineCombined sources1
Cross-linki822Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki829Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki832Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei931PhosphothreonineCombined sources1
Modified residuei946PhosphoserineCombined sources1
Modified residuei948PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO15042
MaxQBiO15042
PaxDbiO15042
PeptideAtlasiO15042
PRIDEiO15042
ProteomicsDBi48397
48398 [O15042-2]
48399 [O15042-3]

PTM databases

iPTMnetiO15042
PhosphoSitePlusiO15042
SwissPalmiO15042

Miscellaneous databases

PMAP-CutDBiO15042

Expressioni

Gene expression databases

BgeeiENSG00000163714 Expressed in 231 organ(s), highest expression level in intestine
ExpressionAtlasiO15042 baseline and differential
GenevisibleiO15042 HS

Organism-specific databases

HPAiHPA037545
HPA037546
HPA061407

Interactioni

Subunit structurei

Interacts with ERBB4.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi116932, 116 interactors
CORUMiO15042
IntActiO15042, 24 interactors
MINTiO15042
STRINGi9606.ENSP00000322376

Structurei

3D structure databases

ProteinModelPortaliO15042
SMRiO15042
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini274 – 355RRMPROSITE-ProRule annotationAdd BLAST82
Repeati430 – 473SURP motifAdd BLAST44
Domaini534 – 679CIDPROSITE-ProRule annotationAdd BLAST146

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili92 – 121Sequence analysisAdd BLAST30
Coiled coili192 – 232Sequence analysisAdd BLAST41
Coiled coili837 – 915Sequence analysisAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi357 – 402Pro-richAdd BLAST46
Compositional biasi689 – 746Asp-richAdd BLAST58
Compositional biasi762 – 917Glu-richAdd BLAST156
Compositional biasi922 – 1001Arg/Ser-richAdd BLAST80

Sequence similaritiesi

Belongs to the splicing factor SR family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0151 Eukaryota
ENOG410XSUI LUCA
GeneTreeiENSGT00390000010687
HOGENOMiHOG000286037
HOVERGENiHBG093996
InParanoidiO15042
KOiK12842
OMAiWGKTVPI
OrthoDBiEOG091G035C
PhylomeDBiO15042
TreeFamiTF318729

Family and domain databases

CDDicd12223 RRM_SR140, 1 hit
Gene3Di1.10.10.790, 1 hit
1.25.40.90, 1 hit
3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR006569 CID_dom
IPR008942 ENTH_VHS
IPR013170 mRNA_splic_Cwf21_dom
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR035009 SR140_RRM
IPR000061 Surp
IPR035967 SWAP/Surp_sf
PfamiView protein in Pfam
PF08312 cwf21, 1 hit
PF00076 RRM_1, 1 hit
PF01805 Surp, 1 hit
SMARTiView protein in SMART
SM01115 cwf21, 1 hit
SM00582 RPR, 1 hit
SM00360 RRM, 1 hit
SM00648 SWAP, 1 hit
SUPFAMiSSF109905 SSF109905, 1 hit
SSF48464 SSF48464, 1 hit
SSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS51391 CID, 1 hit
PS50102 RRM, 1 hit
PS50128 SURP, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O15042-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADKTPGGSQ KASSKTRSSD VHSSGSSDAH MDASGPSDSD MPSRTRPKSP
60 70 80 90 100
RKHNYRNESA RESLCDSPHQ NLSRPLLENK LKAFSIGKMS TAKRTLSKKE
110 120 130 140 150
QEELKKKEDE KAAAEIYEEF LAAFEGSDGN KVKTFVRGGV VNAAKEEHET
160 170 180 190 200
DEKRGKIYKP SSRFADQKNP PNQSSNERPP SLLVIETKKP PLKKGEKEKK
210 220 230 240 250
KSNLELFKEE LKQIQEERDE RHKTKGRLSR FEPPQSDSDG QRRSMDAPSR
260 270 280 290 300
RNRSSGVLDD YAPGSHDVGD PSTTNLYLGN INPQMNEEML CQEFGRFGPL
310 320 330 340 350
ASVKIMWPRT DEERARERNC GFVAFMNRRD AERALKNLNG KMIMSFEMKL
360 370 380 390 400
GWGKAVPIPP HPIYIPPSMM EHTLPPPPSG LPFNAQPRER LKNPNAPMLP
410 420 430 440 450
PPKNKEDFEK TLSQAIVKVV IPTERNLLAL IHRMIEFVVR EGPMFEAMIM
460 470 480 490 500
NREINNPMFR FLFENQTPAH VYYRWKLYSI LQGDSPTKWR TEDFRMFKNG
510 520 530 540 550
SFWRPPPLNP YLHGMSEEQE TEAFVEEPSK KGALKEEQRD KLEEILRGLT
560 570 580 590 600
PRKNDIGDAM VFCLNNAEAA EEIVDCITES LSILKTPLPK KIARLYLVSD
610 620 630 640 650
VLYNSSAKVA NASYYRKFFE TKLCQIFSDL NATYRTIQGH LQSENFKQRV
660 670 680 690 700
MTCFRAWEDW AIYPEPFLIK LQNIFLGLVN IIEEKETEDV PDDLDGAPIE
710 720 730 740 750
EELDGAPLED VDGIPIDATP IDDLDGVPIK SLDDDLDGVP LDATEDSKKN
760 770 780 790 800
EPIFKVAPSK WEAVDESELE AQAVTTSKWE LFDQHEESEE EENQNQEEES
810 820 830 840 850
EDEEDTQSSK SEEHHLYSNP IKEEMTESKF SKYSEMSEEK RAKLREIELK
860 870 880 890 900
VMKFQDELES GKRPKKPGQS FQEQVEHYRD KLLQREKEKE LERERERDKK
910 920 930 940 950
DKEKLESRSK DKKEKDECTP TRKERKRRHS TSPSPSRSSS GRRVKSPSPK
960 970 980 990 1000
SERSERSERS HKESSRSRSS HKDSPRDVSK KAKRSPSGSR TPKRSRRSRS
1010 1020
RSPKKSGKKS RSQSRSPHRS HKKSKKNKH
Length:1,029
Mass (Da):118,292
Last modified:March 6, 2007 - v2
Checksum:i7AB9235C63299714
GO
Isoform 2 (identifier: O15042-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     256-256: Missing.

Show »
Length:1,028
Mass (Da):118,235
Checksum:i626B4D73CC24A992
GO
Isoform 3 (identifier: O15042-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-409: Missing.
     410-424: KTLSQAIVKVVIPTE → MLLCYRHLKTKRILR

Show »
Length:620
Mass (Da):72,523
Checksum:iBA78B39559885CBC
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ET15E7ET15_HUMAN
U2 snRNP-associated SURP motif-cont...
U2SURP
1,028Annotation score:
H7C4V2H7C4V2_HUMAN
U2 snRNP-associated SURP motif-cont...
U2SURP
290Annotation score:
H0Y8D9H0Y8D9_HUMAN
U2 snRNP-associated SURP motif-cont...
U2SURP
439Annotation score:
E7EW00E7EW00_HUMAN
U2 snRNP-associated SURP motif-cont...
U2SURP
425Annotation score:
C9J5L1C9J5L1_HUMAN
U2 snRNP-associated SURP motif-cont...
U2SURP
161Annotation score:
U3KPT1U3KPT1_HUMAN
U2 snRNP-associated SURP motif-cont...
U2SURP
125Annotation score:
C9JDJ7C9JDJ7_HUMAN
U2 snRNP-associated SURP motif-cont...
U2SURP
130Annotation score:

Sequence cautioni

The sequence AAH16323 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAI05605 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0235221 – 409Missing in isoform 3. 1 PublicationAdd BLAST409
Alternative sequenceiVSP_023523256Missing in isoform 2. 1 Publication1
Alternative sequenceiVSP_023524410 – 424KTLSQ…VIPTE → MLLCYRHLKTKRILR in isoform 3. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018450 Genomic DNA No translation available.
AC026304 Genomic DNA No translation available.
BC006474 mRNA Translation: AAH06474.1
BC016323 mRNA Translation: AAH16323.1 Sequence problems.
BC105604 mRNA Translation: AAI05605.1 Sequence problems.
BC111692 mRNA Translation: AAI11693.1
AB002330 mRNA Translation: BAA20790.1
BK000564 mRNA Translation: DAA00075.1
CCDSiCCDS46928.1 [O15042-1]
RefSeqiNP_001073884.1, NM_001080415.1 [O15042-1]
NP_001307148.1, NM_001320219.1 [O15042-2]
NP_001307149.1, NM_001320220.1 [O15042-3]
NP_001307151.1, NM_001320222.1
XP_016861527.1, XM_017006038.1 [O15042-3]
XP_016861528.1, XM_017006039.1 [O15042-3]
UniGeneiHs.596572

Genome annotation databases

EnsembliENST00000473835; ENSP00000418563; ENSG00000163714 [O15042-1]
GeneIDi23350
KEGGihsa:23350
UCSCiuc003evh.2 human [O15042-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018450 Genomic DNA No translation available.
AC026304 Genomic DNA No translation available.
BC006474 mRNA Translation: AAH06474.1
BC016323 mRNA Translation: AAH16323.1 Sequence problems.
BC105604 mRNA Translation: AAI05605.1 Sequence problems.
BC111692 mRNA Translation: AAI11693.1
AB002330 mRNA Translation: BAA20790.1
BK000564 mRNA Translation: DAA00075.1
CCDSiCCDS46928.1 [O15042-1]
RefSeqiNP_001073884.1, NM_001080415.1 [O15042-1]
NP_001307148.1, NM_001320219.1 [O15042-2]
NP_001307149.1, NM_001320220.1 [O15042-3]
NP_001307151.1, NM_001320222.1
XP_016861527.1, XM_017006038.1 [O15042-3]
XP_016861528.1, XM_017006039.1 [O15042-3]
UniGeneiHs.596572

3D structure databases

ProteinModelPortaliO15042
SMRiO15042
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116932, 116 interactors
CORUMiO15042
IntActiO15042, 24 interactors
MINTiO15042
STRINGi9606.ENSP00000322376

PTM databases

iPTMnetiO15042
PhosphoSitePlusiO15042
SwissPalmiO15042

Polymorphism and mutation databases

BioMutaiU2SURP

Proteomic databases

EPDiO15042
MaxQBiO15042
PaxDbiO15042
PeptideAtlasiO15042
PRIDEiO15042
ProteomicsDBi48397
48398 [O15042-2]
48399 [O15042-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000473835; ENSP00000418563; ENSG00000163714 [O15042-1]
GeneIDi23350
KEGGihsa:23350
UCSCiuc003evh.2 human [O15042-1]

Organism-specific databases

CTDi23350
DisGeNETi23350
EuPathDBiHostDB:ENSG00000163714.17
GeneCardsiU2SURP
H-InvDBiHIX0003746
HGNCiHGNC:30855 U2SURP
HPAiHPA037545
HPA037546
HPA061407
MIMi617849 gene
neXtProtiNX_O15042
OpenTargetsiENSG00000163714
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0151 Eukaryota
ENOG410XSUI LUCA
GeneTreeiENSGT00390000010687
HOGENOMiHOG000286037
HOVERGENiHBG093996
InParanoidiO15042
KOiK12842
OMAiWGKTVPI
OrthoDBiEOG091G035C
PhylomeDBiO15042
TreeFamiTF318729

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

ChiTaRSiU2SURP human
GenomeRNAii23350
PMAP-CutDBiO15042
PROiPR:O15042
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163714 Expressed in 231 organ(s), highest expression level in intestine
ExpressionAtlasiO15042 baseline and differential
GenevisibleiO15042 HS

Family and domain databases

CDDicd12223 RRM_SR140, 1 hit
Gene3Di1.10.10.790, 1 hit
1.25.40.90, 1 hit
3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR006569 CID_dom
IPR008942 ENTH_VHS
IPR013170 mRNA_splic_Cwf21_dom
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR035009 SR140_RRM
IPR000061 Surp
IPR035967 SWAP/Surp_sf
PfamiView protein in Pfam
PF08312 cwf21, 1 hit
PF00076 RRM_1, 1 hit
PF01805 Surp, 1 hit
SMARTiView protein in SMART
SM01115 cwf21, 1 hit
SM00582 RPR, 1 hit
SM00360 RRM, 1 hit
SM00648 SWAP, 1 hit
SUPFAMiSSF109905 SSF109905, 1 hit
SSF48464 SSF48464, 1 hit
SSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS51391 CID, 1 hit
PS50102 RRM, 1 hit
PS50128 SURP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSR140_HUMAN
AccessioniPrimary (citable) accession number: O15042
Secondary accession number(s): A0PJ60
, Q0D2M1, Q2NKQ7, Q9BR70
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 6, 2007
Last modified: November 7, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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