UniProtKB - O15042 (SR140_HUMAN)
Protein
U2 snRNP-associated SURP motif-containing protein
Gene
U2SURP
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- RNA binding Source: UniProtKB
GO - Biological processi
- mRNA splicing, via spliceosome Source: Reactome
Keywordsi
Molecular function | RNA-binding |
Enzyme and pathway databases
PathwayCommonsi | O15042 |
Reactomei | R-HSA-72163, mRNA Splicing - Major Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: U2 snRNP-associated SURP motif-containing proteinAlternative name(s): 140 kDa Ser/Arg-rich domain protein U2-associated protein SR140 |
Gene namesi | Name:U2SURP Synonyms:KIAA0332, SR140 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000163714.17 |
HGNCi | HGNC:30855, U2SURP |
MIMi | 617849, gene |
neXtProti | NX_O15042 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 23350 |
OpenTargetsi | ENSG00000163714 |
Miscellaneous databases
Pharosi | O15042, Tbio |
Polymorphism and mutation databases
BioMutai | U2SURP |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000280070 | 2 – 1029 | U2 snRNP-associated SURP motif-containing proteinAdd BLAST | 1028 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 67 | PhosphoserineCombined sources | 1 | |
Cross-linki | 80 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 145 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 168 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 202 | PhosphoserineCombined sources | 1 | |
Cross-linki | 208 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 236 | PhosphoserineCombined sources | 1 | |
Modified residuei | 485 | PhosphoserineCombined sources | 1 | |
Modified residuei | 719 | PhosphothreonineCombined sources | 1 | |
Cross-linki | 748 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 749 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 760 | N6-acetyllysine; alternateCombined sources | 1 | |
Cross-linki | 760 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 788 | PhosphoserineCombined sources | 1 | |
Modified residuei | 800 | PhosphoserineCombined sources | 1 | |
Modified residuei | 811 | PhosphoserineCombined sources | 1 | |
Cross-linki | 822 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 829 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 832 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 931 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 946 | PhosphoserineCombined sources | 1 | |
Modified residuei | 948 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | O15042 |
jPOSTi | O15042 |
MassIVEi | O15042 |
MaxQBi | O15042 |
PaxDbi | O15042 |
PeptideAtlasi | O15042 |
PRIDEi | O15042 |
ProteomicsDBi | 48397 [O15042-1] 48398 [O15042-2] 48399 [O15042-3] |
PTM databases
iPTMneti | O15042 |
MetOSitei | O15042 |
PhosphoSitePlusi | O15042 |
SwissPalmi | O15042 |
Expressioni
Gene expression databases
Bgeei | ENSG00000163714, Expressed in intestine and 241 other tissues |
ExpressionAtlasi | O15042, baseline and differential |
Genevisiblei | O15042, HS |
Organism-specific databases
HPAi | ENSG00000163714, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with ERBB4.
1 PublicationBinary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 116932, 150 interactors |
CORUMi | O15042 |
IntActi | O15042, 43 interactors |
MINTi | O15042 |
STRINGi | 9606.ENSP00000418563 |
Miscellaneous databases
RNActi | O15042, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 274 – 355 | RRMPROSITE-ProRule annotationAdd BLAST | 82 | |
Repeati | 430 – 473 | SURP motifAdd BLAST | 44 | |
Domaini | 534 – 679 | CIDPROSITE-ProRule annotationAdd BLAST | 146 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 92 – 121 | Sequence analysisAdd BLAST | 30 | |
Coiled coili | 192 – 232 | Sequence analysisAdd BLAST | 41 | |
Coiled coili | 837 – 915 | Sequence analysisAdd BLAST | 79 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 357 – 402 | Pro-richAdd BLAST | 46 | |
Compositional biasi | 689 – 746 | Asp-richAdd BLAST | 58 | |
Compositional biasi | 762 – 917 | Glu-richAdd BLAST | 156 | |
Compositional biasi | 922 – 1001 | Arg/Ser-richAdd BLAST | 80 |
Sequence similaritiesi
Belongs to the splicing factor SR family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG0151, Eukaryota |
GeneTreei | ENSGT00390000010687 |
HOGENOMi | CLU_010743_1_0_1 |
InParanoidi | O15042 |
OMAi | SFDTGDP |
OrthoDBi | 523911at2759 |
PhylomeDBi | O15042 |
TreeFami | TF318729 |
Family and domain databases
CDDi | cd12223, RRM_SR140, 1 hit |
Gene3Di | 1.10.10.790, 1 hit 1.25.40.90, 1 hit 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR006569, CID_dom IPR008942, ENTH_VHS IPR013170, mRNA_splic_Cwf21_dom IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR035009, SR140_RRM IPR000061, Surp IPR035967, SWAP/Surp_sf |
Pfami | View protein in Pfam PF04818, CID, 1 hit PF08312, cwf21, 1 hit PF00076, RRM_1, 1 hit PF01805, Surp, 1 hit |
SMARTi | View protein in SMART SM01115, cwf21, 1 hit SM00582, RPR, 1 hit SM00360, RRM, 1 hit SM00648, SWAP, 1 hit |
SUPFAMi | SSF109905, SSF109905, 1 hit SSF48464, SSF48464, 1 hit SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS51391, CID, 1 hit PS50102, RRM, 1 hit PS50128, SURP, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O15042-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MADKTPGGSQ KASSKTRSSD VHSSGSSDAH MDASGPSDSD MPSRTRPKSP
60 70 80 90 100
RKHNYRNESA RESLCDSPHQ NLSRPLLENK LKAFSIGKMS TAKRTLSKKE
110 120 130 140 150
QEELKKKEDE KAAAEIYEEF LAAFEGSDGN KVKTFVRGGV VNAAKEEHET
160 170 180 190 200
DEKRGKIYKP SSRFADQKNP PNQSSNERPP SLLVIETKKP PLKKGEKEKK
210 220 230 240 250
KSNLELFKEE LKQIQEERDE RHKTKGRLSR FEPPQSDSDG QRRSMDAPSR
260 270 280 290 300
RNRSSGVLDD YAPGSHDVGD PSTTNLYLGN INPQMNEEML CQEFGRFGPL
310 320 330 340 350
ASVKIMWPRT DEERARERNC GFVAFMNRRD AERALKNLNG KMIMSFEMKL
360 370 380 390 400
GWGKAVPIPP HPIYIPPSMM EHTLPPPPSG LPFNAQPRER LKNPNAPMLP
410 420 430 440 450
PPKNKEDFEK TLSQAIVKVV IPTERNLLAL IHRMIEFVVR EGPMFEAMIM
460 470 480 490 500
NREINNPMFR FLFENQTPAH VYYRWKLYSI LQGDSPTKWR TEDFRMFKNG
510 520 530 540 550
SFWRPPPLNP YLHGMSEEQE TEAFVEEPSK KGALKEEQRD KLEEILRGLT
560 570 580 590 600
PRKNDIGDAM VFCLNNAEAA EEIVDCITES LSILKTPLPK KIARLYLVSD
610 620 630 640 650
VLYNSSAKVA NASYYRKFFE TKLCQIFSDL NATYRTIQGH LQSENFKQRV
660 670 680 690 700
MTCFRAWEDW AIYPEPFLIK LQNIFLGLVN IIEEKETEDV PDDLDGAPIE
710 720 730 740 750
EELDGAPLED VDGIPIDATP IDDLDGVPIK SLDDDLDGVP LDATEDSKKN
760 770 780 790 800
EPIFKVAPSK WEAVDESELE AQAVTTSKWE LFDQHEESEE EENQNQEEES
810 820 830 840 850
EDEEDTQSSK SEEHHLYSNP IKEEMTESKF SKYSEMSEEK RAKLREIELK
860 870 880 890 900
VMKFQDELES GKRPKKPGQS FQEQVEHYRD KLLQREKEKE LERERERDKK
910 920 930 940 950
DKEKLESRSK DKKEKDECTP TRKERKRRHS TSPSPSRSSS GRRVKSPSPK
960 970 980 990 1000
SERSERSERS HKESSRSRSS HKDSPRDVSK KAKRSPSGSR TPKRSRRSRS
1010 1020
RSPKKSGKKS RSQSRSPHRS HKKSKKNKH
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7ET15 | E7ET15_HUMAN | U2 snRNP-associated SURP motif-cont... | U2SURP | 1,028 | Annotation score: | ||
H7C4V2 | H7C4V2_HUMAN | U2 snRNP-associated SURP motif-cont... | U2SURP | 290 | Annotation score: | ||
C9J5L1 | C9J5L1_HUMAN | U2 snRNP-associated SURP motif-cont... | U2SURP | 161 | Annotation score: | ||
C9JDJ7 | C9JDJ7_HUMAN | U2 snRNP-associated SURP motif-cont... | U2SURP | 130 | Annotation score: | ||
U3KPT1 | U3KPT1_HUMAN | U2 snRNP-associated SURP motif-cont... | U2SURP | 125 | Annotation score: | ||
E7EW00 | E7EW00_HUMAN | U2 snRNP-associated SURP motif-cont... | U2SURP | 425 | Annotation score: | ||
H0Y8D9 | H0Y8D9_HUMAN | U2 snRNP-associated SURP motif-cont... | U2SURP | 439 | Annotation score: |
Sequence cautioni
The sequence AAH16323 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAI05605 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_023522 | 1 – 409 | Missing in isoform 3. 1 PublicationAdd BLAST | 409 | |
Alternative sequenceiVSP_023523 | 256 | Missing in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_023524 | 410 – 424 | KTLSQ…VIPTE → MLLCYRHLKTKRILR in isoform 3. 1 PublicationAdd BLAST | 15 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC018450 Genomic DNA No translation available. AC026304 Genomic DNA No translation available. BC006474 mRNA Translation: AAH06474.1 BC016323 mRNA Translation: AAH16323.1 Sequence problems. BC105604 mRNA Translation: AAI05605.1 Sequence problems. BC111692 mRNA Translation: AAI11693.1 AB002330 mRNA Translation: BAA20790.1 BK000564 mRNA Translation: DAA00075.1 |
CCDSi | CCDS46928.1 [O15042-1] |
RefSeqi | NP_001073884.1, NM_001080415.1 [O15042-1] NP_001307148.1, NM_001320219.1 [O15042-2] NP_001307149.1, NM_001320220.1 [O15042-3] NP_001307151.1, NM_001320222.1 XP_016861527.1, XM_017006038.1 [O15042-3] XP_016861528.1, XM_017006039.1 [O15042-3] |
Genome annotation databases
Ensembli | ENST00000473835; ENSP00000418563; ENSG00000163714 [O15042-1] |
GeneIDi | 23350 |
KEGGi | hsa:23350 |
UCSCi | uc003evh.2, human [O15042-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC018450 Genomic DNA No translation available. AC026304 Genomic DNA No translation available. BC006474 mRNA Translation: AAH06474.1 BC016323 mRNA Translation: AAH16323.1 Sequence problems. BC105604 mRNA Translation: AAI05605.1 Sequence problems. BC111692 mRNA Translation: AAI11693.1 AB002330 mRNA Translation: BAA20790.1 BK000564 mRNA Translation: DAA00075.1 |
CCDSi | CCDS46928.1 [O15042-1] |
RefSeqi | NP_001073884.1, NM_001080415.1 [O15042-1] NP_001307148.1, NM_001320219.1 [O15042-2] NP_001307149.1, NM_001320220.1 [O15042-3] NP_001307151.1, NM_001320222.1 XP_016861527.1, XM_017006038.1 [O15042-3] XP_016861528.1, XM_017006039.1 [O15042-3] |
3D structure databases
SMRi | O15042 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116932, 150 interactors |
CORUMi | O15042 |
IntActi | O15042, 43 interactors |
MINTi | O15042 |
STRINGi | 9606.ENSP00000418563 |
PTM databases
iPTMneti | O15042 |
MetOSitei | O15042 |
PhosphoSitePlusi | O15042 |
SwissPalmi | O15042 |
Polymorphism and mutation databases
BioMutai | U2SURP |
Proteomic databases
EPDi | O15042 |
jPOSTi | O15042 |
MassIVEi | O15042 |
MaxQBi | O15042 |
PaxDbi | O15042 |
PeptideAtlasi | O15042 |
PRIDEi | O15042 |
ProteomicsDBi | 48397 [O15042-1] 48398 [O15042-2] 48399 [O15042-3] |
Protocols and materials databases
Antibodypediai | 48172, 127 antibodies |
Genome annotation databases
Ensembli | ENST00000473835; ENSP00000418563; ENSG00000163714 [O15042-1] |
GeneIDi | 23350 |
KEGGi | hsa:23350 |
UCSCi | uc003evh.2, human [O15042-1] |
Organism-specific databases
CTDi | 23350 |
DisGeNETi | 23350 |
EuPathDBi | HostDB:ENSG00000163714.17 |
GeneCardsi | U2SURP |
HGNCi | HGNC:30855, U2SURP |
HPAi | ENSG00000163714, Low tissue specificity |
MIMi | 617849, gene |
neXtProti | NX_O15042 |
OpenTargetsi | ENSG00000163714 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0151, Eukaryota |
GeneTreei | ENSGT00390000010687 |
HOGENOMi | CLU_010743_1_0_1 |
InParanoidi | O15042 |
OMAi | SFDTGDP |
OrthoDBi | 523911at2759 |
PhylomeDBi | O15042 |
TreeFami | TF318729 |
Enzyme and pathway databases
PathwayCommonsi | O15042 |
Reactomei | R-HSA-72163, mRNA Splicing - Major Pathway |
Miscellaneous databases
BioGRID-ORCSi | 23350, 712 hits in 848 CRISPR screens |
ChiTaRSi | U2SURP, human |
GenomeRNAii | 23350 |
Pharosi | O15042, Tbio |
PROi | PR:O15042 |
RNActi | O15042, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000163714, Expressed in intestine and 241 other tissues |
ExpressionAtlasi | O15042, baseline and differential |
Genevisiblei | O15042, HS |
Family and domain databases
CDDi | cd12223, RRM_SR140, 1 hit |
Gene3Di | 1.10.10.790, 1 hit 1.25.40.90, 1 hit 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR006569, CID_dom IPR008942, ENTH_VHS IPR013170, mRNA_splic_Cwf21_dom IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR035009, SR140_RRM IPR000061, Surp IPR035967, SWAP/Surp_sf |
Pfami | View protein in Pfam PF04818, CID, 1 hit PF08312, cwf21, 1 hit PF00076, RRM_1, 1 hit PF01805, Surp, 1 hit |
SMARTi | View protein in SMART SM01115, cwf21, 1 hit SM00582, RPR, 1 hit SM00360, RRM, 1 hit SM00648, SWAP, 1 hit |
SUPFAMi | SSF109905, SSF109905, 1 hit SSF48464, SSF48464, 1 hit SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS51391, CID, 1 hit PS50102, RRM, 1 hit PS50128, SURP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SR140_HUMAN | |
Accessioni | O15042Primary (citable) accession number: O15042 Secondary accession number(s): A0PJ60 Q9BR70 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 6, 2007 |
Last sequence update: | March 6, 2007 | |
Last modified: | December 2, 2020 | |
This is version 161 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families