UniProtKB - O15042 (SR140_HUMAN)

BLAST

>sp|O15042|SR140_HUMAN U2 snRNP-associated SURP motif-containing protein OS=Homo sapiens OX=9606 GN=U2SURP PE=1 SV=2
MADKTPGGSQKASSKTRSSDVHSSGSSDAHMDASGPSDSDMPSRTRPKSPRKHNYRNESA
RESLCDSPHQNLSRPLLENKLKAFSIGKMSTAKRTLSKKEQEELKKKEDEKAAAEIYEEF
LAAFEGSDGNKVKTFVRGGVVNAAKEEHETDEKRGKIYKPSSRFADQKNPPNQSSNERPP
SLLVIETKKPPLKKGEKEKKKSNLELFKEELKQIQEERDERHKTKGRLSRFEPPQSDSDG
QRRSMDAPSRRNRSSGVLDDYAPGSHDVGDPSTTNLYLGNINPQMNEEMLCQEFGRFGPL
ASVKIMWPRTDEERARERNCGFVAFMNRRDAERALKNLNGKMIMSFEMKLGWGKAVPIPP
HPIYIPPSMMEHTLPPPPSGLPFNAQPRERLKNPNAPMLPPPKNKEDFEKTLSQAIVKVV
IPTERNLLALIHRMIEFVVREGPMFEAMIMNREINNPMFRFLFENQTPAHVYYRWKLYSI
LQGDSPTKWRTEDFRMFKNGSFWRPPPLNPYLHGMSEEQETEAFVEEPSKKGALKEEQRD
KLEEILRGLTPRKNDIGDAMVFCLNNAEAAEEIVDCITESLSILKTPLPKKIARLYLVSD
VLYNSSAKVANASYYRKFFETKLCQIFSDLNATYRTIQGHLQSENFKQRVMTCFRAWEDW
AIYPEPFLIKLQNIFLGLVNIIEEKETEDVPDDLDGAPIEEELDGAPLEDVDGIPIDATP
IDDLDGVPIKSLDDDLDGVPLDATEDSKKNEPIFKVAPSKWEAVDESELEAQAVTTSKWE
LFDQHEESEEEENQNQEEESEDEEDTQSSKSEEHHLYSNPIKEEMTESKFSKYSEMSEEK
RAKLREIELKVMKFQDELESGKRPKKPGQSFQEQVEHYRDKLLQREKEKELERERERDKK
DKEKLESRSKDKKEKDECTPTRKERKRRHSTSPSPSRSSSGRRVKSPSPKSERSERSERS
HKESSRSRSSHKDSPRDVSKKAKRSPSGSRTPKRSRRSRSRSPKKSGKKSRSQSRSPHRS
HKKSKKNKH

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History
Entry version 143 (07 Nov 2018)
Sequence version 2 (06 Mar 2007)
Previous versions | rss
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Protein

U2 snRNP-associated SURP motif-containing protein

Gene

U2SURP

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

GO - Molecular functionⁱ

RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22681889

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mRNA splicing, via spliceosome Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	RNA-binding

Molecular function

RNA-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-72163 mRNA Splicing - Major Pathway

Reactomeⁱ

R-HSA-72163 mRNA Splicing - Major Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: U2 snRNP-associated SURP motif-containing protein Alternative name(s): 140 kDa Ser/Arg-rich domain protein U2-associated protein SR140
Gene namesⁱ	Name:U2SURP Synonyms:KIAA0332, SR140
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000163714.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30855 U2SURP
MIMⁱ	617849 gene
neXtProtⁱ	NX_O15042

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	23350
Open Targets More...OpenTargetsⁱ	ENSG00000163714

Polymorphism and mutation databases

BioMutaⁱ	U2SURP

BioMutaⁱ

U2SURP

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000280070	2 – 1029	U2 snRNP-associated SURP motif-containing proteinAdd BLAST		1028

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources	1
Modified residueⁱ	67	PhosphoserineCombined sources	1
Cross-linkⁱ	80	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	145	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	168	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	202	PhosphoserineCombined sources	1
Cross-linkⁱ	208	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	236	PhosphoserineCombined sources	1
Modified residueⁱ	485	PhosphoserineCombined sources	1
Modified residueⁱ	719	PhosphothreonineCombined sources	1
Cross-linkⁱ	748	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	749	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	760	N6-acetyllysine; alternateCombined sources	1
Cross-linkⁱ	760	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residueⁱ	788	PhosphoserineCombined sources	1
Modified residueⁱ	800	PhosphoserineCombined sources	1
Modified residueⁱ	811	PhosphoserineCombined sources	1
Cross-linkⁱ	822	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	829	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	832	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	931	PhosphothreonineCombined sources	1
Modified residueⁱ	946	PhosphoserineCombined sources	1
Modified residueⁱ	948	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	O15042
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O15042
PaxDbⁱ	O15042
PeptideAtlas More...PeptideAtlasⁱ	O15042
PRIDEⁱ	O15042
ProteomicsDBⁱ	48397 48398 [O15042-2] 48399 [O15042-3]

PTM databases

iPTMnetⁱ	O15042
PhosphoSitePlusⁱ	O15042
SwissPalmⁱ	O15042

Miscellaneous databases

PMAP-CutDBⁱ	O15042

PMAP-CutDBⁱ

O15042

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000163714 Expressed in 231 organ(s), highest expression level in intestine
ExpressionAtlasⁱ	O15042 baseline and differential
Genevisibleⁱ	O15042 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA037545 HPA037546 HPA061407

HPAⁱ

HPA037545
HPA037546
HPA061407

Interactionⁱ

Subunit structureⁱ

Interacts with ERBB4.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
RBM10	P98175	2	EBI-310697,EBI-721525
RBM5	P52756	2	EBI-310697,EBI-714003

Protein-protein interaction databases

BioGridⁱ	116932, 116 interactors
CORUMⁱ	O15042
IntActⁱ	O15042, 24 interactors
Molecular INTeraction database More...MINTⁱ	O15042
STRINGⁱ	9606.ENSP00000322376

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O15042
SMRⁱ	O15042
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	274 – 355	RRMPROSITE-ProRule annotationAdd BLAST	82
Repeatⁱ	430 – 473	SURP motifAdd BLAST	44
Domainⁱ	534 – 679	CIDPROSITE-ProRule annotationAdd BLAST	146

Coiled coil

Feature key	Position(s)	DescriptionActions	Length
Coiled coilⁱ	92 – 121	Sequence analysisAdd BLAST	30
Coiled coilⁱ	192 – 232	Sequence analysisAdd BLAST	41
Coiled coilⁱ	837 – 915	Sequence analysisAdd BLAST	79

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	357 – 402	Pro-richAdd BLAST	46
Compositional biasⁱ	689 – 746	Asp-richAdd BLAST	58
Compositional biasⁱ	762 – 917	Glu-richAdd BLAST	156
Compositional biasⁱ	922 – 1001	Arg/Ser-richAdd BLAST	80

Sequence similaritiesⁱ

Belongs to the splicing factor SR family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG0151 Eukaryota ENOG410XSUI LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000010687
HOGENOMⁱ	HOG000286037
HOVERGENⁱ	HBG093996
InParanoidⁱ	O15042
KEGG Orthology (KO) More...KOⁱ	K12842
OMAⁱ	WGKTVPI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G035C
PhylomeDBⁱ	O15042
TreeFamⁱ	TF318729

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd12223 RRM_SR140, 1 hit
Gene3Dⁱ	1.10.10.790, 1 hit 1.25.40.90, 1 hit 3.30.70.330, 1 hit
InterProⁱ	View protein in InterPro IPR006569 CID_dom IPR008942 ENTH_VHS IPR013170 mRNA_splic_Cwf21_dom IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR000504 RRM_dom IPR035009 SR140_RRM IPR000061 Surp IPR035967 SWAP/Surp_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08312 cwf21, 1 hit PF00076 RRM_1, 1 hit PF01805 Surp, 1 hit
SMARTⁱ	View protein in SMART SM01115 cwf21, 1 hit SM00582 RPR, 1 hit SM00360 RRM, 1 hit SM00648 SWAP, 1 hit
SUPFAMⁱ	SSF109905 SSF109905, 1 hit SSF48464 SSF48464, 1 hit SSF54928 SSF54928, 1 hit
PROSITEⁱ	View protein in PROSITE PS51391 CID, 1 hit PS50102 RRM, 1 hit PS50128 SURP, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O15042-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADKTPGGSQ KASSKTRSSD VHSSGSSDAH MDASGPSDSD MPSRTRPKSP 
        60         70         80         90        100
RKHNYRNESA RESLCDSPHQ NLSRPLLENK LKAFSIGKMS TAKRTLSKKE 
       110        120        130        140        150
QEELKKKEDE KAAAEIYEEF LAAFEGSDGN KVKTFVRGGV VNAAKEEHET 
       160        170        180        190        200
DEKRGKIYKP SSRFADQKNP PNQSSNERPP SLLVIETKKP PLKKGEKEKK 
       210        220        230        240        250
KSNLELFKEE LKQIQEERDE RHKTKGRLSR FEPPQSDSDG QRRSMDAPSR 
       260        270        280        290        300
RNRSSGVLDD YAPGSHDVGD PSTTNLYLGN INPQMNEEML CQEFGRFGPL 
       310        320        330        340        350
ASVKIMWPRT DEERARERNC GFVAFMNRRD AERALKNLNG KMIMSFEMKL 
       360        370        380        390        400
GWGKAVPIPP HPIYIPPSMM EHTLPPPPSG LPFNAQPRER LKNPNAPMLP 
       410        420        430        440        450
PPKNKEDFEK TLSQAIVKVV IPTERNLLAL IHRMIEFVVR EGPMFEAMIM 
       460        470        480        490        500
NREINNPMFR FLFENQTPAH VYYRWKLYSI LQGDSPTKWR TEDFRMFKNG 
       510        520        530        540        550
SFWRPPPLNP YLHGMSEEQE TEAFVEEPSK KGALKEEQRD KLEEILRGLT 
       560        570        580        590        600
PRKNDIGDAM VFCLNNAEAA EEIVDCITES LSILKTPLPK KIARLYLVSD 
       610        620        630        640        650
VLYNSSAKVA NASYYRKFFE TKLCQIFSDL NATYRTIQGH LQSENFKQRV 
       660        670        680        690        700
MTCFRAWEDW AIYPEPFLIK LQNIFLGLVN IIEEKETEDV PDDLDGAPIE 
       710        720        730        740        750
EELDGAPLED VDGIPIDATP IDDLDGVPIK SLDDDLDGVP LDATEDSKKN 
       760        770        780        790        800
EPIFKVAPSK WEAVDESELE AQAVTTSKWE LFDQHEESEE EENQNQEEES 
       810        820        830        840        850
EDEEDTQSSK SEEHHLYSNP IKEEMTESKF SKYSEMSEEK RAKLREIELK 
       860        870        880        890        900
VMKFQDELES GKRPKKPGQS FQEQVEHYRD KLLQREKEKE LERERERDKK 
       910        920        930        940        950
DKEKLESRSK DKKEKDECTP TRKERKRRHS TSPSPSRSSS GRRVKSPSPK 
       960        970        980        990       1000
SERSERSERS HKESSRSRSS HKDSPRDVSK KAKRSPSGSR TPKRSRRSRS 
      1010       1020 
RSPKKSGKKS RSQSRSPHRS HKKSKKNKH

Length:1,029

Mass (Da):118,292

Last modified:March 6, 2007 - v2

Checksum:ⁱ7AB9235C63299714

Isoform 2 (identifier: O15042-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
256-256: Missing.

« Hide

        10         20         30         40         50
MADKTPGGSQ KASSKTRSSD VHSSGSSDAH MDASGPSDSD MPSRTRPKSP 
        60         70         80         90        100
RKHNYRNESA RESLCDSPHQ NLSRPLLENK LKAFSIGKMS TAKRTLSKKE 
       110        120        130        140        150
QEELKKKEDE KAAAEIYEEF LAAFEGSDGN KVKTFVRGGV VNAAKEEHET 
       160        170        180        190        200
DEKRGKIYKP SSRFADQKNP PNQSSNERPP SLLVIETKKP PLKKGEKEKK 
       210        220        230        240        250
KSNLELFKEE LKQIQEERDE RHKTKGRLSR FEPPQSDSDG QRRSMDAPSR 
       260        270        280        290        300
RNRSSVLDDY APGSHDVGDP STTNLYLGNI NPQMNEEMLC QEFGRFGPLA 
       310        320        330        340        350
SVKIMWPRTD EERARERNCG FVAFMNRRDA ERALKNLNGK MIMSFEMKLG 
       360        370        380        390        400
WGKAVPIPPH PIYIPPSMME HTLPPPPSGL PFNAQPRERL KNPNAPMLPP 
       410        420        430        440        450
PKNKEDFEKT LSQAIVKVVI PTERNLLALI HRMIEFVVRE GPMFEAMIMN 
       460        470        480        490        500
REINNPMFRF LFENQTPAHV YYRWKLYSIL QGDSPTKWRT EDFRMFKNGS 
       510        520        530        540        550
FWRPPPLNPY LHGMSEEQET EAFVEEPSKK GALKEEQRDK LEEILRGLTP 
       560        570        580        590        600
RKNDIGDAMV FCLNNAEAAE EIVDCITESL SILKTPLPKK IARLYLVSDV 
       610        620        630        640        650
LYNSSAKVAN ASYYRKFFET KLCQIFSDLN ATYRTIQGHL QSENFKQRVM 
       660        670        680        690        700
TCFRAWEDWA IYPEPFLIKL QNIFLGLVNI IEEKETEDVP DDLDGAPIEE 
       710        720        730        740        750
ELDGAPLEDV DGIPIDATPI DDLDGVPIKS LDDDLDGVPL DATEDSKKNE 
       760        770        780        790        800
PIFKVAPSKW EAVDESELEA QAVTTSKWEL FDQHEESEEE ENQNQEEESE 
       810        820        830        840        850
DEEDTQSSKS EEHHLYSNPI KEEMTESKFS KYSEMSEEKR AKLREIELKV 
       860        870        880        890        900
MKFQDELESG KRPKKPGQSF QEQVEHYRDK LLQREKEKEL ERERERDKKD 
       910        920        930        940        950
KEKLESRSKD KKEKDECTPT RKERKRRHST SPSPSRSSSG RRVKSPSPKS 
       960        970        980        990       1000
ERSERSERSH KESSRSRSSH KDSPRDVSKK AKRSPSGSRT PKRSRRSRSR 
      1010       1020 
SPKKSGKKSR SQSRSPHRSH KKSKKNKH

Show »

Length:1,028

Mass (Da):118,235

Checksum:ⁱ626B4D73CC24A992

Isoform 3 (identifier: O15042-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-409: Missing.
410-424: KTLSQAIVKVVIPTE → MLLCYRHLKTKRILR

« Hide

        10         20         30         40         50
MLLCYRHLKT KRILRRNLLA LIHRMIEFVV REGPMFEAMI MNREINNPMF 
        60         70         80         90        100
RFLFENQTPA HVYYRWKLYS ILQGDSPTKW RTEDFRMFKN GSFWRPPPLN 
       110        120        130        140        150
PYLHGMSEEQ ETEAFVEEPS KKGALKEEQR DKLEEILRGL TPRKNDIGDA 
       160        170        180        190        200
MVFCLNNAEA AEEIVDCITE SLSILKTPLP KKIARLYLVS DVLYNSSAKV 
       210        220        230        240        250
ANASYYRKFF ETKLCQIFSD LNATYRTIQG HLQSENFKQR VMTCFRAWED 
       260        270        280        290        300
WAIYPEPFLI KLQNIFLGLV NIIEEKETED VPDDLDGAPI EEELDGAPLE 
       310        320        330        340        350
DVDGIPIDAT PIDDLDGVPI KSLDDDLDGV PLDATEDSKK NEPIFKVAPS 
       360        370        380        390        400
KWEAVDESEL EAQAVTTSKW ELFDQHEESE EEENQNQEEE SEDEEDTQSS 
       410        420        430        440        450
KSEEHHLYSN PIKEEMTESK FSKYSEMSEE KRAKLREIEL KVMKFQDELE 
       460        470        480        490        500
SGKRPKKPGQ SFQEQVEHYR DKLLQREKEK ELERERERDK KDKEKLESRS 
       510        520        530        540        550
KDKKEKDECT PTRKERKRRH STSPSPSRSS SGRRVKSPSP KSERSERSER 
       560        570        580        590        600
SHKESSRSRS SHKDSPRDVS KKAKRSPSGS RTPKRSRRSR SRSPKKSGKK 
       610        620
SRSQSRSPHR SHKKSKKNKH

Show »

Length:620

Mass (Da):72,523

Checksum:ⁱBA78B39559885CBC

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E7ET15	E7ET15_HUMAN	U2 snRNP-associated SURP motif-cont... U2 snRNP-associated SURP motif-containing protein	U2SURP	1,028	Annotation score:
H7C4V2	H7C4V2_HUMAN	U2 snRNP-associated SURP motif-cont... U2 snRNP-associated SURP motif-containing protein	U2SURP	290	Annotation score:
H0Y8D9	H0Y8D9_HUMAN	U2 snRNP-associated SURP motif-cont... U2 snRNP-associated SURP motif-containing protein	U2SURP	439	Annotation score:
E7EW00	E7EW00_HUMAN	U2 snRNP-associated SURP motif-cont... U2 snRNP-associated SURP motif-containing protein	U2SURP	425	Annotation score:
C9J5L1	C9J5L1_HUMAN	U2 snRNP-associated SURP motif-cont... U2 snRNP-associated SURP motif-containing protein	U2SURP	161	Annotation score:
U3KPT1	U3KPT1_HUMAN	U2 snRNP-associated SURP motif-cont... U2 snRNP-associated SURP motif-containing protein	U2SURP	125	Annotation score:
C9JDJ7	C9JDJ7_HUMAN	U2 snRNP-associated SURP motif-cont... U2 snRNP-associated SURP motif-containing protein	U2SURP	130	Annotation score:

Sequence cautionⁱ

The sequence AAH16323 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

The sequence AAI05605 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_023522	1 – 409	Missing in isoform 3. 1 PublicationAdd BLAST	409
Alternative sequenceⁱVSP_023523	256	Missing in isoform 2. 1 Publication	1
Alternative sequenceⁱVSP_023524	410 – 424	KTLSQ…VIPTE → MLLCYRHLKTKRILR in isoform 3. 1 PublicationAdd BLAST	15

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC018450 Genomic DNA No translation available. AC026304 Genomic DNA No translation available. BC006474 mRNA Translation: AAH06474.1 BC016323 mRNA Translation: AAH16323.1 Sequence problems. BC105604 mRNA Translation: AAI05605.1 Sequence problems. BC111692 mRNA Translation: AAI11693.1 AB002330 mRNA Translation: BAA20790.1 BK000564 mRNA Translation: DAA00075.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS46928.1 [O15042-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001073884.1, NM_001080415.1 [O15042-1] NP_001307148.1, NM_001320219.1 [O15042-2] NP_001307149.1, NM_001320220.1 [O15042-3] NP_001307151.1, NM_001320222.1 XP_016861527.1, XM_017006038.1 [O15042-3] XP_016861528.1, XM_017006039.1 [O15042-3]
UniGeneⁱ	Hs.596572

Genome annotation databases

Ensemblⁱ	ENST00000473835; ENSP00000418563; ENSG00000163714 [O15042-1]
GeneIDⁱ	23350
KEGGⁱ	hsa:23350
UCSC genome browser More...UCSCⁱ	uc003evh.2 human [O15042-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O15042	U2 snRNP associated SURP domain containing		MACMU		1029	UniRef100_O15042
U2 snRNP associated SURP domain containing		SAIBB		1029
U2SURP isoform 1		PONAB		1029
Uncharacterized protein		CERAT		1029
Uncharacterized protein		PAPAN		1029
+7
O15042-2	U2 snRNP-associated SURP motif-containing protein		MACMU		1028	UniRef100_H9FS02
Uncharacterized protein		FELCA		1028

Protein	Similar proteins		Species	Score	Length	Source
O15042	U2 snRNP-associated SURP motif-containing protein		MOUSE		1029	UniRef90_O15042
U2 snRNP-associated SURP motif-containing protein		PONAB		1028
U2 snRNP associated SURP domain containing		MACMU		1029
U2 snRNP associated SURP domain containing		SAIBB		1029
Uncharacterized protein		CERAT		1029
+443
O15042-3	U2 snRNP-associated SURP motif-containing protein isoform X4		DELLE		620	UniRef90_O15042-3
U2 snRNP-associated SURP motif-containing protein isoform X4		PHYCD		620
U2 snRNP-associated SURP motif-containing protein isoform X4		TURTR		620
U2 snRNP-associated SURP motif-containing protein isoform X4		Yangtze finless porpoise		620
U2 snRNP-associated SURP motif-containing protein isoform X2		ERIEU		620
+64

Protein	Similar proteins		Species	Score	Length	Source
O15042	U2 snRNP-associated SURP motif-containing protein		MOUSE		1029	UniRef50_O15042
U2 snRNP-associated SURP motif-containing protein		PONAB		1028
U2 snRNP associated SURP domain containing		MACMU		1029
U2 snRNP associated SURP domain containing		SAIBB		1029
Uncharacterized protein		CERAT		1029
+737
O15042-3	U2 snRNP-associated SURP motif-containing protein isoform X4		DELLE		620	UniRef50_O15042-3
U2 snRNP-associated SURP motif-containing protein isoform X4		PHYCD		620
U2 snRNP-associated SURP motif-containing protein isoform X4		TURTR		620
U2 snRNP-associated SURP motif-containing protein isoform X4		Yangtze finless porpoise		620
U2 snRNP-associated SURP motif-containing protein isoform X5		Florida manatee		620
+68

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC018450 Genomic DNA No translation available. AC026304 Genomic DNA No translation available. BC006474 mRNA Translation: AAH06474.1 BC016323 mRNA Translation: AAH16323.1 Sequence problems. BC105604 mRNA Translation: AAI05605.1 Sequence problems. BC111692 mRNA Translation: AAI11693.1 AB002330 mRNA Translation: BAA20790.1 BK000564 mRNA Translation: DAA00075.1
CCDSⁱ	CCDS46928.1 [O15042-1]
RefSeqⁱ	NP_001073884.1, NM_001080415.1 [O15042-1] NP_001307148.1, NM_001320219.1 [O15042-2] NP_001307149.1, NM_001320220.1 [O15042-3] NP_001307151.1, NM_001320222.1 XP_016861527.1, XM_017006038.1 [O15042-3] XP_016861528.1, XM_017006039.1 [O15042-3]
UniGeneⁱ	Hs.596572

3D structure databases

ProteinModelPortalⁱ	O15042
SMRⁱ	O15042
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116932, 116 interactors
CORUMⁱ	O15042
IntActⁱ	O15042, 24 interactors
MINTⁱ	O15042
STRINGⁱ	9606.ENSP00000322376

PTM databases

iPTMnetⁱ	O15042
PhosphoSitePlusⁱ	O15042
SwissPalmⁱ	O15042

Polymorphism and mutation databases

BioMutaⁱ	U2SURP

BioMutaⁱ

U2SURP

Proteomic databases

EPDⁱ	O15042
MaxQBⁱ	O15042
PaxDbⁱ	O15042
PeptideAtlasⁱ	O15042
PRIDEⁱ	O15042
ProteomicsDBⁱ	48397 48398 [O15042-2] 48399 [O15042-3]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000473835; ENSP00000418563; ENSG00000163714 [O15042-1]
GeneIDⁱ	23350
KEGGⁱ	hsa:23350
UCSCⁱ	uc003evh.2 human [O15042-1]

Organism-specific databases

CTDⁱ	23350
DisGeNETⁱ	23350
EuPathDBⁱ	HostDB:ENSG00000163714.17
GeneCardsⁱ	U2SURP
H-InvDBⁱ	HIX0003746
HGNCⁱ	HGNC:30855 U2SURP
HPAⁱ	HPA037545 HPA037546 HPA061407
MIMⁱ	617849 gene
neXtProtⁱ	NX_O15042
OpenTargetsⁱ	ENSG00000163714
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0151 Eukaryota ENOG410XSUI LUCA
GeneTreeⁱ	ENSGT00390000010687
HOGENOMⁱ	HOG000286037
HOVERGENⁱ	HBG093996
InParanoidⁱ	O15042
KOⁱ	K12842
OMAⁱ	WGKTVPI
OrthoDBⁱ	EOG091G035C
PhylomeDBⁱ	O15042
TreeFamⁱ	TF318729

Enzyme and pathway databases

Reactomeⁱ	R-HSA-72163 mRNA Splicing - Major Pathway

Reactomeⁱ

R-HSA-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

ChiTaRSⁱ	U2SURP human
GenomeRNAiⁱ	23350
PMAP-CutDBⁱ	O15042
Protein Ontology More...PROⁱ	PR:O15042
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000163714 Expressed in 231 organ(s), highest expression level in intestine
ExpressionAtlasⁱ	O15042 baseline and differential
Genevisibleⁱ	O15042 HS

Family and domain databases

CDDⁱ	cd12223 RRM_SR140, 1 hit
Gene3Dⁱ	1.10.10.790, 1 hit 1.25.40.90, 1 hit 3.30.70.330, 1 hit
InterProⁱ	View protein in InterPro IPR006569 CID_dom IPR008942 ENTH_VHS IPR013170 mRNA_splic_Cwf21_dom IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR000504 RRM_dom IPR035009 SR140_RRM IPR000061 Surp IPR035967 SWAP/Surp_sf
Pfamⁱ	View protein in Pfam PF08312 cwf21, 1 hit PF00076 RRM_1, 1 hit PF01805 Surp, 1 hit
SMARTⁱ	View protein in SMART SM01115 cwf21, 1 hit SM00582 RPR, 1 hit SM00360 RRM, 1 hit SM00648 SWAP, 1 hit
SUPFAMⁱ	SSF109905 SSF109905, 1 hit SSF48464 SSF48464, 1 hit SSF54928 SSF54928, 1 hit
PROSITEⁱ	View protein in PROSITE PS51391 CID, 1 hit PS50102 RRM, 1 hit PS50128 SURP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SR140_HUMAN
Accessionⁱ	O15042Primary (citable) accession number: O15042 Secondary accession number(s): A0PJ60 , Q0D2M1, Q2NKQ7, Q9BR70
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 6, 2007
	Last sequence update:	March 6, 2007
	Last modified:	November 7, 2018
	This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - O15042 (SR140_HUMAN)

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U2 snRNP-associated SURP motif-containing protein

U2SURP

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

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Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ