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Protein

Semaphorin-3E

Gene

SEMA3E

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity of synapse formation (By similarity).By similarity

GO - Molecular functioni

  • chemorepellent activity Source: GO_Central
  • neuropilin binding Source: GO_Central
  • semaphorin receptor binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processAngiogenesis, Differentiation, Neurogenesis

Enzyme and pathway databases

ReactomeiR-HSA-416700 Other semaphorin interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-3E
Gene namesi
Name:SEMA3E
Synonyms:KIAA0331, SEMAH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000170381.12
HGNCiHGNC:10727 SEMA3E
MIMi608166 gene
neXtProtiNX_O15041

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi9723
MalaCardsiSEMA3E
OpenTargetsiENSG00000170381
Orphaneti138 CHARGE syndrome
PharmGKBiPA35649

Polymorphism and mutation databases

BioMutaiSEMA3E

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000003231726 – 775Semaphorin-3EAdd BLAST750

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi44N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi105 ↔ 115By similarity
Glycosylationi126N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi133 ↔ 142By similarity
Disulfide bondi270 ↔ 382By similarity
Disulfide bondi294 ↔ 342By similarity
Glycosylationi330N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi519 ↔ 537By similarity
Glycosylationi595N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi596N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi654 ↔ 729By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO15041
PeptideAtlasiO15041
PRIDEiO15041
ProteomicsDBi48396

PTM databases

iPTMnetiO15041
PhosphoSitePlusiO15041

Expressioni

Gene expression databases

BgeeiENSG00000170381 Expressed in 144 organ(s), highest expression level in lung
CleanExiHS_SEMA3E
ExpressionAtlasiO15041 baseline and differential
GenevisibleiO15041 HS

Organism-specific databases

HPAiHPA029419
HPA063804

Interactioni

Subunit structurei

Interacts with PLXND1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
PLXND1Q9Y4D72EBI-7283693,EBI-310731

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115072, 1 interactor
IntActiO15041, 1 interactor
MINTiO15041
STRINGi9606.ENSP00000303212

Structurei

3D structure databases

ProteinModelPortaliO15041
SMRiO15041
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 516SemaPROSITE-ProRule annotationAdd BLAST485
Domaini581 – 669Ig-like C2-typeAdd BLAST89

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi737 – 770Arg/Lys-rich (basic)Add BLAST34

Sequence similaritiesi

Belongs to the semaphorin family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiKOG3611 Eukaryota
ENOG410XQZC LUCA
GeneTreeiENSGT00760000118854
HOGENOMiHOG000039964
HOVERGENiHBG055071
InParanoidiO15041
KOiK06840
OMAiYWGRDAA
OrthoDBiEOG091G01WA
PhylomeDBiO15041
TreeFamiTF352628

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013151 Immunoglobulin
IPR016201 PSI
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR027231 Semaphorin
IPR015513 Semaphorin_3E
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR11036 PTHR11036, 1 hit
PTHR11036:SF22 PTHR11036:SF22, 1 hit
PfamiView protein in Pfam
PF00047 ig, 1 hit
PF01403 Sema, 1 hit
SMARTiView protein in SMART
SM00423 PSI, 1 hit
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51004 SEMA, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O15041-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASAGHIITL LLWGYLLELW TGGHTADTTH PRLRLSHKEL LNLNRTSIFH
60 70 80 90 100
SPFGFLDLHT MLLDEYQERL FVGGRDLVYS LSLERISDGY KEIHWPSTAL
110 120 130 140 150
KMEECIMKGK DAGECANYVR VLHHYNRTHL LTCGTGAFDP VCAFIRVGYH
160 170 180 190 200
LEDPLFHLES PRSERGRGRC PFDPSSSFIS TLIGSELFAG LYSDYWSRDA
210 220 230 240 250
AIFRSMGRLA HIRTEHDDER LLKEPKFVGS YMIPDNEDRD DNKVYFFFTE
260 270 280 290 300
KALEAENNAH AIYTRVGRLC VNDVGGQRIL VNKWSTFLKA RLVCSVPGMN
310 320 330 340 350
GIDTYFDELE DVFLLPTRDH KNPVIFGLFN TTSNIFRGHA ICVYHMSSIR
360 370 380 390 400
AAFNGPYAHK EGPEYHWSVY EGKVPYPRPG SCASKVNGGR YGTTKDYPDD
410 420 430 440 450
AIRFARSHPL MYQAIKPAHK KPILVKTDGK YNLKQIAVDR VEAEDGQYDV
460 470 480 490 500
LFIGTDNGIV LKVITIYNQE MESMEEVILE ELQIFKDPVP IISMEISSKR
510 520 530 540 550
QQLYIGSASA VAQVRFHHCD MYGSACADCC LARDPYCAWD GISCSRYYPT
560 570 580 590 600
GTHAKRRFRR QDVRHGNAAQ QCFGQQFVGD ALDKTEEHLA YGIENNSTLL
610 620 630 640 650
ECTPRSLQAK VIWFVQKGRE TRKEEVKTDD RVVKMDLGLL FLRLHKSDAG
660 670 680 690 700
TYFCQTVEHS FVHTVRKITL EVVEEEKVED MFNKDDEEDR HHRMPCPAQS
710 720 730 740 750
SISQGAKPWY KEFLQLIGYS NFQRVEEYCE KVWCTDRKRK KLKMSPSKWK
760 770
YANPQEKKLR SKPEHYRLPR HTLDS
Length:775
Mass (Da):89,228
Last modified:January 1, 1998 - v1
Checksum:iCD6079C1AE48F779
GO
Isoform 2 (identifier: O15041-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: Missing.

Note: No experimental confirmation available.
Show »
Length:715
Mass (Da):82,424
Checksum:iF50FFAD229C17EAA
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8YCX5A0A2R8YCX5_HUMAN
Semaphorin-3E
SEMA3E
630Annotation score:
F8WCZ5F8WCZ5_HUMAN
Semaphorin-3E
SEMA3E
39Annotation score:

Sequence cautioni

The sequence BAA20789 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_080476208R → P1 PublicationCorresponds to variant dbSNP:rs61729612EnsemblClinVar.1
Natural variantiVAR_080477619R → C1 PublicationCorresponds to variant dbSNP:rs143631464EnsemblClinVar.1
Natural variantiVAR_080478703S → L Found in a patient with CHARGE syndrome; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs121918341EnsemblClinVar.1
Natural variantiVAR_080479717I → V1 PublicationCorresponds to variant dbSNP:rs61729610EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0462371 – 60Missing in isoform 2. 1 PublicationAdd BLAST60

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002329 mRNA Translation: BAA20789.2 Different initiation.
AK303925 mRNA Translation: BAG64853.1
AC004954 Genomic DNA Translation: AAC69513.1
AC006204 Genomic DNA No translation available.
AC079799 Genomic DNA Translation: AAS07488.1
AC079987 Genomic DNA Translation: AAS07487.1
CCDSiCCDS34674.1 [O15041-1]
CCDS55121.1 [O15041-2]
RefSeqiNP_001171600.1, NM_001178129.1 [O15041-2]
NP_036563.1, NM_012431.2 [O15041-1]
UniGeneiHs.528721

Genome annotation databases

EnsembliENST00000307792; ENSP00000303212; ENSG00000170381 [O15041-1]
ENST00000427262; ENSP00000405052; ENSG00000170381 [O15041-2]
ENST00000643230; ENSP00000496491; ENSG00000170381 [O15041-1]
GeneIDi9723
KEGGihsa:9723
UCSCiuc003uhy.3 human [O15041-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002329 mRNA Translation: BAA20789.2 Different initiation.
AK303925 mRNA Translation: BAG64853.1
AC004954 Genomic DNA Translation: AAC69513.1
AC006204 Genomic DNA No translation available.
AC079799 Genomic DNA Translation: AAS07488.1
AC079987 Genomic DNA Translation: AAS07487.1
CCDSiCCDS34674.1 [O15041-1]
CCDS55121.1 [O15041-2]
RefSeqiNP_001171600.1, NM_001178129.1 [O15041-2]
NP_036563.1, NM_012431.2 [O15041-1]
UniGeneiHs.528721

3D structure databases

ProteinModelPortaliO15041
SMRiO15041
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115072, 1 interactor
IntActiO15041, 1 interactor
MINTiO15041
STRINGi9606.ENSP00000303212

PTM databases

iPTMnetiO15041
PhosphoSitePlusiO15041

Polymorphism and mutation databases

BioMutaiSEMA3E

Proteomic databases

PaxDbiO15041
PeptideAtlasiO15041
PRIDEiO15041
ProteomicsDBi48396

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307792; ENSP00000303212; ENSG00000170381 [O15041-1]
ENST00000427262; ENSP00000405052; ENSG00000170381 [O15041-2]
ENST00000643230; ENSP00000496491; ENSG00000170381 [O15041-1]
GeneIDi9723
KEGGihsa:9723
UCSCiuc003uhy.3 human [O15041-1]

Organism-specific databases

CTDi9723
DisGeNETi9723
EuPathDBiHostDB:ENSG00000170381.12
GeneCardsiSEMA3E
HGNCiHGNC:10727 SEMA3E
HPAiHPA029419
HPA063804
MalaCardsiSEMA3E
MIMi608166 gene
neXtProtiNX_O15041
OpenTargetsiENSG00000170381
Orphaneti138 CHARGE syndrome
PharmGKBiPA35649
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3611 Eukaryota
ENOG410XQZC LUCA
GeneTreeiENSGT00760000118854
HOGENOMiHOG000039964
HOVERGENiHBG055071
InParanoidiO15041
KOiK06840
OMAiYWGRDAA
OrthoDBiEOG091G01WA
PhylomeDBiO15041
TreeFamiTF352628

Enzyme and pathway databases

ReactomeiR-HSA-416700 Other semaphorin interactions

Miscellaneous databases

ChiTaRSiSEMA3E human
GenomeRNAii9723
PROiPR:O15041
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170381 Expressed in 144 organ(s), highest expression level in lung
CleanExiHS_SEMA3E
ExpressionAtlasiO15041 baseline and differential
GenevisibleiO15041 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013151 Immunoglobulin
IPR016201 PSI
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR027231 Semaphorin
IPR015513 Semaphorin_3E
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR11036 PTHR11036, 1 hit
PTHR11036:SF22 PTHR11036:SF22, 1 hit
PfamiView protein in Pfam
PF00047 ig, 1 hit
PF01403 Sema, 1 hit
SMARTiView protein in SMART
SM00423 PSI, 1 hit
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51004 SEMA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSEM3E_HUMAN
AccessioniPrimary (citable) accession number: O15041
Secondary accession number(s): B4E1P1, Q75M94, Q75M97
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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