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Entry version 127 (08 May 2019)
Sequence version 3 (11 Jan 2011)
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Protein

Protein KHNYN

Gene

KHNYN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein KHNYN
Alternative name(s):
KH and NYN domain-containing protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KHNYN
Synonyms:KIAA0323
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:20166 KHNYN

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O15037

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000100441

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165479143

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KHNYN

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000842901 – 678Protein KHNYNAdd BLAST678

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei10PhosphoserineCombined sources1
Modified residuei359PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O15037

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O15037

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O15037

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O15037

PeptideAtlas

More...
PeptideAtlasi
O15037

PRoteomics IDEntifications database

More...
PRIDEi
O15037

ProteomicsDB human proteome resource

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ProteomicsDBi
48394

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O15037

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O15037

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000100441 Expressed in 212 organ(s), highest expression level in right ovary

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O15037 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O15037 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA003402

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116933, 5 interactors

Protein interaction database and analysis system

More...
IntActi
O15037, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000251343

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1678
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2N5MNMR-A627-678[»]
2N7KNMR-B627-678[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O15037

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the N4BP1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3777 Eukaryota
ENOG410ZNK1 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161993

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O15037

Identification of Orthologs from Complete Genome Data

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OMAi
PEPPWHC

Database of Orthologous Groups

More...
OrthoDBi
771251at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O15037

TreeFam database of animal gene trees

More...
TreeFami
TF315783

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036612 KH_dom_type_1_sf
IPR021869 RNase_Zc3h12_NYN

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11977 RNase_Zc3h12a, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54791 SSF54791, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O15037-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPTWGARPAS PDRFAVSAEA ENKVREQQPH VERIFSVGVS VLPKDCPDNP
60 70 80 90 100
HIWLQLEGPK ENASRAKEYL KGLCSPELQD EIHYPPKLHC IFLGAQGFFL
110 120 130 140 150
DCLAWSTSAH LVPRAPGSLM ISGLTEAFVM AQSRVEELAE RLSWDFTPGP
160 170 180 190 200
SSGASQCTGV LRDFSALLQS PGDAHREALL QLPLAVQEEL LSLVQEASSG
210 220 230 240 250
QGPGALASWE GRSSALLGAQ CQGVRAPPSD GRESLDTGSM GPGDCRGARG
260 270 280 290 300
DTYAVEKEGG KQGGPREMDW GWKELPGEEA WEREVALRPQ SVGGGARESA
310 320 330 340 350
PLKGKALGKE EIALGGGGFC VHREPPGAHG SCHRAAQSRG ASLLQRLHNG
360 370 380 390 400
NASPPRVPSP PPAPEPPWHC GDRGDCGDRG DVGDRGDKQQ GMARGRGPQW
410 420 430 440 450
KRGARGGNLV TGTQRFKEAL QDPFTLCLAN VPGQPDLRHI VIDGSNVAMV
460 470 480 490 500
HGLQHYFSSR GIAIAVQYFW DRGHRDITVF VPQWRFSKDA KVRESHFLQK
510 520 530 540 550
LYSLSLLSLT PSRVMDGKRI SSYDDRFMVK LAEETDGIIV SNDQFRDLAE
560 570 580 590 600
ESEKWMAIIR ERLLPFTFVG NLFMVPDDPL GRNGPTLDEF LKKPARTQGS
610 620 630 640 650
SKAQHPSRGF AEHGKQQQGR EEEKGSGGIR KTRETERLRR QLLEVFWGQD
660 670
HKVDFILQRE PYCRDINQLS EALLSLNF
Length:678
Mass (Da):74,534
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4E52D096B545430D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V331G3V331_HUMAN
Protein KHNYN
KHNYN
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V3G3G3V3G3_HUMAN
Protein KHNYN
KHNYN
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA20781 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_030843261K → T1 PublicationCorresponds to variant dbSNP:rs3742520Ensembl.1
Natural variantiVAR_030844270W → L2 PublicationsCorresponds to variant dbSNP:rs7151995Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB002321 mRNA Translation: BAA20781.1 Different initiation.
BX161465 mRNA Translation: CAD61924.1
AL132800 Genomic DNA No translation available.
BC015780 mRNA Translation: AAH15780.1
BC042554 mRNA Translation: AAH42554.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32058.1

NCBI Reference Sequences

More...
RefSeqi
NP_001277185.1, NM_001290256.1
NP_001277186.1, NM_001290257.1
NP_056114.1, NM_015299.2
XP_005267531.1, XM_005267474.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000251343; ENSP00000251343; ENSG00000100441
ENST00000553935; ENSP00000450799; ENSG00000100441
ENST00000556842; ENSP00000451106; ENSG00000100441

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23351

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23351

UCSC genome browser

More...
UCSCi
uc001wph.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002321 mRNA Translation: BAA20781.1 Different initiation.
BX161465 mRNA Translation: CAD61924.1
AL132800 Genomic DNA No translation available.
BC015780 mRNA Translation: AAH15780.1
BC042554 mRNA Translation: AAH42554.1
CCDSiCCDS32058.1
RefSeqiNP_001277185.1, NM_001290256.1
NP_001277186.1, NM_001290257.1
NP_056114.1, NM_015299.2
XP_005267531.1, XM_005267474.4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2N5MNMR-A627-678[»]
2N7KNMR-B627-678[»]
SMRiO15037
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116933, 5 interactors
IntActiO15037, 4 interactors
STRINGi9606.ENSP00000251343

PTM databases

iPTMnetiO15037
PhosphoSitePlusiO15037

Polymorphism and mutation databases

BioMutaiKHNYN

Proteomic databases

EPDiO15037
jPOSTiO15037
MaxQBiO15037
PaxDbiO15037
PeptideAtlasiO15037
PRIDEiO15037
ProteomicsDBi48394

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000251343; ENSP00000251343; ENSG00000100441
ENST00000553935; ENSP00000450799; ENSG00000100441
ENST00000556842; ENSP00000451106; ENSG00000100441
GeneIDi23351
KEGGihsa:23351
UCSCiuc001wph.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23351

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KHNYN

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0202038
HGNCiHGNC:20166 KHNYN
HPAiHPA003402
neXtProtiNX_O15037
OpenTargetsiENSG00000100441
PharmGKBiPA165479143

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3777 Eukaryota
ENOG410ZNK1 LUCA
GeneTreeiENSGT00940000161993
InParanoidiO15037
OMAiPEPPWHC
OrthoDBi771251at2759
PhylomeDBiO15037
TreeFamiTF315783

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
KHNYN human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23351

Protein Ontology

More...
PROi
PR:O15037

Gene expression databases

BgeeiENSG00000100441 Expressed in 212 organ(s), highest expression level in right ovary
ExpressionAtlasiO15037 baseline and differential
GenevisibleiO15037 HS

Family and domain databases

InterProiView protein in InterPro
IPR036612 KH_dom_type_1_sf
IPR021869 RNase_Zc3h12_NYN
PfamiView protein in Pfam
PF11977 RNase_Zc3h12a, 1 hit
SUPFAMiSSF54791 SSF54791, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKHNYN_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15037
Secondary accession number(s): Q86TZ6, Q8IUQ2, Q96BA9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: January 11, 2011
Last modified: May 8, 2019
This is version 127 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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