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Protein

RIMS-binding protein 2

Gene

RIMBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • negative regulation of phosphatase activity Source: UniProtKB
  • neuromuscular synaptic transmission Source: GO_Central

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RIMS-binding protein 2
Short name:
RIM-BP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RIMBP2
Synonyms:KIAA0318, RBP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000060709.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30339 RIMBP2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611602 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O15034

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23504

Open Targets

More...
OpenTargetsi
ENSG00000060709

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485594

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RIMBP2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002213831 – 1052RIMS-binding protein 2Add BLAST1052

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei704PhosphoserineBy similarity1
Modified residuei712PhosphoserineBy similarity1
Modified residuei832PhosphoserineBy similarity1
Modified residuei839PhosphoserineBy similarity1
Modified residuei841PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O15034

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O15034

PeptideAtlas

More...
PeptideAtlasi
O15034

PRoteomics IDEntifications database

More...
PRIDEi
O15034

ProteomicsDB human proteome resource

More...
ProteomicsDBi
48391
48392 [O15034-2]
48393 [O15034-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O15034

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O15034

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000060709 Expressed in 151 organ(s), highest expression level in superior frontal gyrus

CleanEx database of gene expression profiles

More...
CleanExi
HS_RBP2
HS_RIMBP2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O15034 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O15034 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RIMS1, RIMS2, CACNA1D and CACNA1B, and potentially with other Ca2+ channel alpha-1 isoforms.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117051, 3 interactors

Protein interaction database and analysis system

More...
IntActi
O15034, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000261655

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11052
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WIENMR-A160-242[»]
2CSINMR-A955-1017[»]
2CSPNMR-A477-593[»]
2CSQNMR-A841-924[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O15034

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O15034

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O15034

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini167 – 234SH3 1PROSITE-ProRule annotationAdd BLAST68
Domaini297 – 390Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST94
Domaini393 – 475Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST83
Domaini489 – 590Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST102
Domaini848 – 916SH3 2PROSITE-ProRule annotationAdd BLAST69
Domaini952 – 1019SH3 3PROSITE-ProRule annotationAdd BLAST68

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi582 – 663Pro-richAdd BLAST82

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SH3 domains mediate binding to a proline-rich motif in RIMS1, RIMS2, CACNA1D and CACNA1B.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RIMBP family.Curated

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3632 Eukaryota
ENOG410XZ8W LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156214

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000139176

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG079131

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O15034

KEGG Orthology (KO)

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KOi
K17591

Identification of Orthologs from Complete Genome Data

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OMAi
SPNIDVE

Database of Orthologous Groups

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OrthoDBi
102427at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O15034

TreeFam database of animal gene trees

More...
TreeFami
TF316230

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 3 hits
cd12012 SH3_RIM-BP_2, 1 hit
cd12013 SH3_RIM-BP_3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR035519 RIM-BP2
IPR035753 RIM-BP_SH3_2
IPR035755 RIM-BP_SH3_3
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

The PANTHER Classification System

More...
PANTHERi
PTHR14234:SF18 PTHR14234:SF18, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07653 SH3_2, 1 hit
PF14604 SH3_9, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00452 SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 3 hits
SM00326 SH3, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 2 hits
SSF50044 SSF50044, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 3 hits
PS50002 SH3, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O15034-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MREAAERRQQ LQLEHDQALA VLSAKQQEID LLQKSKVREL EEKCRTQSEQ
60 70 80 90 100
FNLLSRDLEK FRQHAGKIDL LGGSAVAPLD ISTAPSKPFP QFMNGLATSL
110 120 130 140 150
GKGQESAIGG SSAIGEYIRP LPQPGDRPEP LSAKPTFLSR SGSARCRSES
160 170 180 190 200
DMENERNSNT SKQRYSGKVH LCVARYSYNP FDGPNENPEA ELPLTAGKYL
210 220 230 240 250
YVYGDMDEDG FYEGELLDGQ RGLVPSNFVD FVQDNESRLA STLGNEQDQN
260 270 280 290 300
FINHSGIGLE GEHILDLHSP THIDAGITDN SAGTLDVNID DIGEDIVPYP
310 320 330 340 350
RKITLIKQLA KSVIVGWEPP AVPPGWGTVS SYNVLVDKET RMNLTLGSRT
360 370 380 390 400
KALIEKLNMA ACTYRISVQC VTSRGSSDEL QCTLLVGKDV VVAPSHLRVD
410 420 430 440 450
NITQISAQLS WLPTNSNYSH VIFLNEEEFD IVKAARYKYQ FFNLRPNMAY
460 470 480 490 500
KVKVLAKPHQ MPWQLPLEQR EKKEAFVEFS TLPAGPPAPP QDVTVQAGVT
510 520 530 540 550
PATIRVSWRP PVLTPTGLSN GANVTGYGVY AKGQRVAEVI FPTADSTAVE
560 570 580 590 600
LVRLRSLEAK GVTVRTLSAQ GESVDSAVAA VPPELLVPPT PHPRPAPQSK
610 620 630 640 650
PLASSGVPET KDEHLGPHAR MDEAWEQSRA PGPVHGHMLE PPVGPGRRSP
660 670 680 690 700
SPSRILPQPQ GTPVSTTVAK AMAREAAQRV AESSRLEKRS VFLERSSAGQ
710 720 730 740 750
YAASDEEDAY DSPDFKRRGA SVDDFLKGSE LGKQPHCCHG DEYHTESSRG
760 770 780 790 800
SDLSDIMEED EEELYSEMQL EDGGRRRPSG TSHNALKILG NPASAGRVDH
810 820 830 840 850
MGRRFPRGSA GPQRSRPVTV PSIDDYGRDR LSPDFYEESE TDPGAEELPA
860 870 880 890 900
RIFVALFDYD PLTMSPNPDA AEEELPFKEG QIIKVYGDKD ADGFYRGETC
910 920 930 940 950
ARLGLIPCNM VSEIQADDEE MMDQLLRQGF LPLNTPVEKI ERSRRSGRRH
960 970 980 990 1000
SVSTRRMVAL YDYDPRESSP NVDVEAELTF CTGDIITVFG EIDEDGFYYG
1010 1020 1030 1040 1050
ELNGQKGLVP SNFLEEVPDD VEVYLSDAPS HYSQDTPMRS KAKRKKSVHF

TP
Length:1,052
Mass (Da):116,026
Last modified:June 16, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i065FADD690A7A8BC
GO
Isoform 2 (identifier: O15034-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: Missing.
     735-737: PHC → MVS
     738-1052: Missing.

Show »
Length:645
Mass (Da):70,108
Checksum:i7E978DF41DAB449A
GO
Isoform 3 (identifier: O15034-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-863: Missing.
     1045-1052: KKSVHFTP → VSKPI

Note: No experimental confirmation available.
Show »
Length:186
Mass (Da):20,992
Checksum:i4DAF7B9B3328436B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y6Z0A0A2R8Y6Z0_HUMAN
RIMS-binding protein 2
RIMBP2
1,362Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YFN7A0A2R8YFN7_HUMAN
RIMS-binding protein 2
RIMBP2
811Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y5H8A0A2R8Y5H8_HUMAN
RIMS-binding protein 2
RIMBP2
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YF94A0A2R8YF94_HUMAN
RIMS-binding protein 2
RIMBP2
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2U3TZP8A0A2U3TZP8_HUMAN
RIMS-binding protein 2
RIMBP2
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YFN4H0YFN4_HUMAN
RIMS-binding protein 2
RIMBP2
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA20776 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1051T → I in BAA20776 (PubMed:9205841).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_057714593P → R. Corresponds to variant dbSNP:rs2292664Ensembl.1
Natural variantiVAR_057715888D → N. Corresponds to variant dbSNP:rs11060869Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0092131 – 863Missing in isoform 3. 1 PublicationAdd BLAST863
Alternative sequenceiVSP_0092121 – 92Missing in isoform 2. 1 PublicationAdd BLAST92
Alternative sequenceiVSP_009214735 – 737PHC → MVS in isoform 2. 1 Publication3
Alternative sequenceiVSP_009215738 – 1052Missing in isoform 2. 1 PublicationAdd BLAST315
Alternative sequenceiVSP_0092161045 – 1052KKSVHFTP → VSKPI in isoform 3. 1 Publication8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB002316 mRNA Translation: BAA20776.1 Different initiation.
BX641152 mRNA Translation: CAE46066.1
AC063926 Genomic DNA No translation available.
BC007632 mRNA Translation: AAH07632.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS31925.1 [O15034-1]

NCBI Reference Sequences

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RefSeqi
NP_056162.4, NM_015347.4 [O15034-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.657441

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000261655; ENSP00000261655; ENSG00000060709 [O15034-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23504

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23504

UCSC genome browser

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UCSCi
uc001uil.3 human [O15034-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002316 mRNA Translation: BAA20776.1 Different initiation.
BX641152 mRNA Translation: CAE46066.1
AC063926 Genomic DNA No translation available.
BC007632 mRNA Translation: AAH07632.1
CCDSiCCDS31925.1 [O15034-1]
RefSeqiNP_056162.4, NM_015347.4 [O15034-1]
UniGeneiHs.657441

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WIENMR-A160-242[»]
2CSINMR-A955-1017[»]
2CSPNMR-A477-593[»]
2CSQNMR-A841-924[»]
ProteinModelPortaliO15034
SMRiO15034
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117051, 3 interactors
IntActiO15034, 4 interactors
STRINGi9606.ENSP00000261655

PTM databases

iPTMnetiO15034
PhosphoSitePlusiO15034

Polymorphism and mutation databases

BioMutaiRIMBP2

Proteomic databases

EPDiO15034
PaxDbiO15034
PeptideAtlasiO15034
PRIDEiO15034
ProteomicsDBi48391
48392 [O15034-2]
48393 [O15034-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
23504
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261655; ENSP00000261655; ENSG00000060709 [O15034-1]
GeneIDi23504
KEGGihsa:23504
UCSCiuc001uil.3 human [O15034-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23504
DisGeNETi23504
EuPathDBiHostDB:ENSG00000060709.13

GeneCards: human genes, protein and diseases

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GeneCardsi
RIMBP2

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0011135
HIX0026522
HGNCiHGNC:30339 RIMBP2
MIMi611602 gene
neXtProtiNX_O15034
OpenTargetsiENSG00000060709
PharmGKBiPA143485594

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3632 Eukaryota
ENOG410XZ8W LUCA
GeneTreeiENSGT00940000156214
HOGENOMiHOG000139176
HOVERGENiHBG079131
InParanoidiO15034
KOiK17591
OMAiSPNIDVE
OrthoDBi102427at2759
PhylomeDBiO15034
TreeFamiTF316230

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RIMBP2 human
EvolutionaryTraceiO15034

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23504

Protein Ontology

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PROi
PR:O15034

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000060709 Expressed in 151 organ(s), highest expression level in superior frontal gyrus
CleanExiHS_RBP2
HS_RIMBP2
ExpressionAtlasiO15034 baseline and differential
GenevisibleiO15034 HS

Family and domain databases

CDDicd00063 FN3, 3 hits
cd12012 SH3_RIM-BP_2, 1 hit
cd12013 SH3_RIM-BP_3, 1 hit
Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR035519 RIM-BP2
IPR035753 RIM-BP_SH3_2
IPR035755 RIM-BP_SH3_3
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR14234:SF18 PTHR14234:SF18, 1 hit
PfamiView protein in Pfam
PF07653 SH3_2, 1 hit
PF14604 SH3_9, 2 hits
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00060 FN3, 3 hits
SM00326 SH3, 3 hits
SUPFAMiSSF49265 SSF49265, 2 hits
SSF50044 SSF50044, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 3 hits
PS50002 SH3, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRIMB2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15034
Secondary accession number(s): Q96ID2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 16, 2009
Last modified: January 16, 2019
This is version 153 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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