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Protein

RIMS-binding protein 2

Gene

RIMBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B.By similarity

GO - Biological processi

  • negative regulation of phosphatase activity Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
RIMS-binding protein 2
Short name:
RIM-BP2
Gene namesi
Name:RIMBP2
Synonyms:KIAA0318, RBP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000060709.13
HGNCiHGNC:30339 RIMBP2
MIMi611602 gene
neXtProtiNX_O15034

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi23504
OpenTargetsiENSG00000060709
PharmGKBiPA143485594

Polymorphism and mutation databases

BioMutaiRIMBP2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002213831 – 1052RIMS-binding protein 2Add BLAST1052

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei704PhosphoserineBy similarity1
Modified residuei712PhosphoserineBy similarity1
Modified residuei832PhosphoserineBy similarity1
Modified residuei839PhosphoserineBy similarity1
Modified residuei841PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO15034
PaxDbiO15034
PeptideAtlasiO15034
PRIDEiO15034
ProteomicsDBi48391
48392 [O15034-2]
48393 [O15034-3]

PTM databases

iPTMnetiO15034
PhosphoSitePlusiO15034

Expressioni

Gene expression databases

BgeeiENSG00000060709 Expressed in 151 organ(s), highest expression level in superior frontal gyrus
CleanExiHS_RBP2
HS_RIMBP2
ExpressionAtlasiO15034 baseline and differential
GenevisibleiO15034 HS

Interactioni

Subunit structurei

Interacts with RIMS1, RIMS2, CACNA1D and CACNA1B, and potentially with other Ca2+ channel alpha-1 isoforms.By similarity

Protein-protein interaction databases

BioGridi117051, 3 interactors
IntActiO15034, 4 interactors
STRINGi9606.ENSP00000261655

Structurei

Secondary structure

11052
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO15034
SMRiO15034
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO15034

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini167 – 234SH3 1PROSITE-ProRule annotationAdd BLAST68
Domaini297 – 390Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST94
Domaini393 – 475Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST83
Domaini489 – 590Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST102
Domaini848 – 916SH3 2PROSITE-ProRule annotationAdd BLAST69
Domaini952 – 1019SH3 3PROSITE-ProRule annotationAdd BLAST68

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi582 – 663Pro-richAdd BLAST82

Domaini

The SH3 domains mediate binding to a proline-rich motif in RIMS1, RIMS2, CACNA1D and CACNA1B.By similarity

Sequence similaritiesi

Belongs to the RIMBP family.Curated

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG3632 Eukaryota
ENOG410XZ8W LUCA
GeneTreeiENSGT00390000017228
HOGENOMiHOG000139176
HOVERGENiHBG079131
InParanoidiO15034
KOiK17591
OMAiLNMAACT
OrthoDBiEOG091G02RN
PhylomeDBiO15034
TreeFamiTF316230

Family and domain databases

CDDicd00063 FN3, 3 hits
cd12012 SH3_RIM-BP_2, 1 hit
cd12013 SH3_RIM-BP_3, 1 hit
Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR035519 RIM-BP2
IPR035753 RIM-BP_SH3_2
IPR035755 RIM-BP_SH3_3
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR14234:SF18 PTHR14234:SF18, 1 hit
PfamiView protein in Pfam
PF07653 SH3_2, 1 hit
PF14604 SH3_9, 2 hits
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00060 FN3, 3 hits
SM00326 SH3, 3 hits
SUPFAMiSSF49265 SSF49265, 2 hits
SSF50044 SSF50044, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 3 hits
PS50002 SH3, 3 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O15034-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MREAAERRQQ LQLEHDQALA VLSAKQQEID LLQKSKVREL EEKCRTQSEQ
60 70 80 90 100
FNLLSRDLEK FRQHAGKIDL LGGSAVAPLD ISTAPSKPFP QFMNGLATSL
110 120 130 140 150
GKGQESAIGG SSAIGEYIRP LPQPGDRPEP LSAKPTFLSR SGSARCRSES
160 170 180 190 200
DMENERNSNT SKQRYSGKVH LCVARYSYNP FDGPNENPEA ELPLTAGKYL
210 220 230 240 250
YVYGDMDEDG FYEGELLDGQ RGLVPSNFVD FVQDNESRLA STLGNEQDQN
260 270 280 290 300
FINHSGIGLE GEHILDLHSP THIDAGITDN SAGTLDVNID DIGEDIVPYP
310 320 330 340 350
RKITLIKQLA KSVIVGWEPP AVPPGWGTVS SYNVLVDKET RMNLTLGSRT
360 370 380 390 400
KALIEKLNMA ACTYRISVQC VTSRGSSDEL QCTLLVGKDV VVAPSHLRVD
410 420 430 440 450
NITQISAQLS WLPTNSNYSH VIFLNEEEFD IVKAARYKYQ FFNLRPNMAY
460 470 480 490 500
KVKVLAKPHQ MPWQLPLEQR EKKEAFVEFS TLPAGPPAPP QDVTVQAGVT
510 520 530 540 550
PATIRVSWRP PVLTPTGLSN GANVTGYGVY AKGQRVAEVI FPTADSTAVE
560 570 580 590 600
LVRLRSLEAK GVTVRTLSAQ GESVDSAVAA VPPELLVPPT PHPRPAPQSK
610 620 630 640 650
PLASSGVPET KDEHLGPHAR MDEAWEQSRA PGPVHGHMLE PPVGPGRRSP
660 670 680 690 700
SPSRILPQPQ GTPVSTTVAK AMAREAAQRV AESSRLEKRS VFLERSSAGQ
710 720 730 740 750
YAASDEEDAY DSPDFKRRGA SVDDFLKGSE LGKQPHCCHG DEYHTESSRG
760 770 780 790 800
SDLSDIMEED EEELYSEMQL EDGGRRRPSG TSHNALKILG NPASAGRVDH
810 820 830 840 850
MGRRFPRGSA GPQRSRPVTV PSIDDYGRDR LSPDFYEESE TDPGAEELPA
860 870 880 890 900
RIFVALFDYD PLTMSPNPDA AEEELPFKEG QIIKVYGDKD ADGFYRGETC
910 920 930 940 950
ARLGLIPCNM VSEIQADDEE MMDQLLRQGF LPLNTPVEKI ERSRRSGRRH
960 970 980 990 1000
SVSTRRMVAL YDYDPRESSP NVDVEAELTF CTGDIITVFG EIDEDGFYYG
1010 1020 1030 1040 1050
ELNGQKGLVP SNFLEEVPDD VEVYLSDAPS HYSQDTPMRS KAKRKKSVHF

TP
Length:1,052
Mass (Da):116,026
Last modified:June 16, 2009 - v3
Checksum:i065FADD690A7A8BC
GO
Isoform 2 (identifier: O15034-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: Missing.
     735-737: PHC → MVS
     738-1052: Missing.

Show »
Length:645
Mass (Da):70,108
Checksum:i7E978DF41DAB449A
GO
Isoform 3 (identifier: O15034-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-863: Missing.
     1045-1052: KKSVHFTP → VSKPI

Note: No experimental confirmation available.
Show »
Length:186
Mass (Da):20,992
Checksum:i4DAF7B9B3328436B
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y6Z0A0A2R8Y6Z0_HUMAN
RIMS-binding protein 2
RIMBP2
1,362Annotation score:
A0A2R8YFN7A0A2R8YFN7_HUMAN
RIMS-binding protein 2
RIMBP2
811Annotation score:
A0A2U3TZP8A0A2U3TZP8_HUMAN
RIMS-binding protein 2
RIMBP2
79Annotation score:
A0A2R8Y5H8A0A2R8Y5H8_HUMAN
RIMS-binding protein 2
RIMBP2
119Annotation score:
A0A2R8YF94A0A2R8YF94_HUMAN
RIMS-binding protein 2
RIMBP2
44Annotation score:
H0YFN4H0YFN4_HUMAN
RIMS-binding protein 2
RIMBP2
62Annotation score:

Sequence cautioni

The sequence BAA20776 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1051T → I in BAA20776 (PubMed:9205841).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057714593P → R. Corresponds to variant dbSNP:rs2292664Ensembl.1
Natural variantiVAR_057715888D → N. Corresponds to variant dbSNP:rs11060869Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0092131 – 863Missing in isoform 3. 1 PublicationAdd BLAST863
Alternative sequenceiVSP_0092121 – 92Missing in isoform 2. 1 PublicationAdd BLAST92
Alternative sequenceiVSP_009214735 – 737PHC → MVS in isoform 2. 1 Publication3
Alternative sequenceiVSP_009215738 – 1052Missing in isoform 2. 1 PublicationAdd BLAST315
Alternative sequenceiVSP_0092161045 – 1052KKSVHFTP → VSKPI in isoform 3. 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002316 mRNA Translation: BAA20776.1 Different initiation.
BX641152 mRNA Translation: CAE46066.1
AC063926 Genomic DNA No translation available.
BC007632 mRNA Translation: AAH07632.1
CCDSiCCDS31925.1 [O15034-1]
RefSeqiNP_056162.4, NM_015347.4 [O15034-1]
UniGeneiHs.657441

Genome annotation databases

EnsembliENST00000261655; ENSP00000261655; ENSG00000060709 [O15034-1]
GeneIDi23504
KEGGihsa:23504
UCSCiuc001uil.3 human [O15034-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002316 mRNA Translation: BAA20776.1 Different initiation.
BX641152 mRNA Translation: CAE46066.1
AC063926 Genomic DNA No translation available.
BC007632 mRNA Translation: AAH07632.1
CCDSiCCDS31925.1 [O15034-1]
RefSeqiNP_056162.4, NM_015347.4 [O15034-1]
UniGeneiHs.657441

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WIENMR-A160-242[»]
2CSINMR-A955-1017[»]
2CSPNMR-A477-593[»]
2CSQNMR-A841-924[»]
ProteinModelPortaliO15034
SMRiO15034
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117051, 3 interactors
IntActiO15034, 4 interactors
STRINGi9606.ENSP00000261655

PTM databases

iPTMnetiO15034
PhosphoSitePlusiO15034

Polymorphism and mutation databases

BioMutaiRIMBP2

Proteomic databases

EPDiO15034
PaxDbiO15034
PeptideAtlasiO15034
PRIDEiO15034
ProteomicsDBi48391
48392 [O15034-2]
48393 [O15034-3]

Protocols and materials databases

DNASUi23504
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261655; ENSP00000261655; ENSG00000060709 [O15034-1]
GeneIDi23504
KEGGihsa:23504
UCSCiuc001uil.3 human [O15034-1]

Organism-specific databases

CTDi23504
DisGeNETi23504
EuPathDBiHostDB:ENSG00000060709.13
GeneCardsiRIMBP2
H-InvDBiHIX0011135
HIX0026522
HGNCiHGNC:30339 RIMBP2
MIMi611602 gene
neXtProtiNX_O15034
OpenTargetsiENSG00000060709
PharmGKBiPA143485594
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3632 Eukaryota
ENOG410XZ8W LUCA
GeneTreeiENSGT00390000017228
HOGENOMiHOG000139176
HOVERGENiHBG079131
InParanoidiO15034
KOiK17591
OMAiLNMAACT
OrthoDBiEOG091G02RN
PhylomeDBiO15034
TreeFamiTF316230

Miscellaneous databases

ChiTaRSiRIMBP2 human
EvolutionaryTraceiO15034
GenomeRNAii23504
PROiPR:O15034
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000060709 Expressed in 151 organ(s), highest expression level in superior frontal gyrus
CleanExiHS_RBP2
HS_RIMBP2
ExpressionAtlasiO15034 baseline and differential
GenevisibleiO15034 HS

Family and domain databases

CDDicd00063 FN3, 3 hits
cd12012 SH3_RIM-BP_2, 1 hit
cd12013 SH3_RIM-BP_3, 1 hit
Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR035519 RIM-BP2
IPR035753 RIM-BP_SH3_2
IPR035755 RIM-BP_SH3_3
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR14234:SF18 PTHR14234:SF18, 1 hit
PfamiView protein in Pfam
PF07653 SH3_2, 1 hit
PF14604 SH3_9, 2 hits
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00060 FN3, 3 hits
SM00326 SH3, 3 hits
SUPFAMiSSF49265 SSF49265, 2 hits
SSF50044 SSF50044, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 3 hits
PS50002 SH3, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiRIMB2_HUMAN
AccessioniPrimary (citable) accession number: O15034
Secondary accession number(s): Q96ID2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 16, 2009
Last modified: September 12, 2018
This is version 150 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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