UniProtKB - O15031 (PLXB2_HUMAN)

BLAST

>sp|O15031|PLXB2_HUMAN Plexin-B2 OS=Homo sapiens OX=9606 GN=PLXNB2 PE=1 SV=3
MALQLWALTLLGLLGAGASLRPRKLDFFRSEKELNHLAVDEASGVVYLGAVNALYQLDAK
LQLEQQVATGPALDNKKCTPPIEASQCHEAEMTDNVNQLLLLDPPRKRLVECGSLFKGIC
ALRALSNISLRLFYEDGSGEKSFVASNDEGVATVGLVSSTGPGGDRVLFVGKGNGPHDNG
IIVSTRLLDRTDSREAFEAYTDHATYKAGYLSTNTQQFVAAFEDGPYVFFVFNQQDKHPA
RNRTLLARMCREDPNYYSYLEMDLQCRDPDIHAAAFGTCLAASVAAPGSGRVLYAVFSRD
SRSSGGPGAGLCLFPLDKVHAKMEANRNACYTGTREARDIFYKPFHGDIQCGGHAPGSSK
SFPCGSEHLPYPLGSRDGLRGTAVLQRGGLNLTAVTVAAENNHTVAFLGTSDGRILKVYL
TPDGTSSEYDSILVEINKRVKRDLVLSGDLGSLYAMTQDKVFRLPVQECLSYPTCTQCRD
SQDPYCGWCVVEGRCTRKAECPRAEEASHWLWSRSKSCVAVTSAQPQNMSRRAQGEVQLT
VSPLPALSEEDELLCLFGESPPHPARVEGEAVICNSPSSIPVTPPGQDHVAVTIQLLLRR
GNIFLTSYQYPFYDCRQAMSLEENLPCISCVSNRWTCQWDLRYHECREASPNPEDGIVRA
HMEDSCPQFLGPSPLVIPMNHETDVNFQGKNLDTVKGSSLHVGSDLLKFMEPVTMQESGT
FAFRTPKLSHDANETLPLHLYVKSYGKNIDSKLHVTLYNCSFGRSDCSLCRAANPDYRCA
WCGGQSRCVYEALCNTTSECPPPVITRIQPETGPLGGGIRITILGSNLGVQAGDIQRISV
AGRNCSFQPERYSVSTRIVCVIEAAETPFTGGVEVDVFGKLGRSPPNVQFTFQQPKPLSV
EPQQGPQAGGTTLTIHGTHLDTGSQEDVRVTLNGVPCKVTKFGAQLQCVTGPQATRGQML
LEVSYGGSPVPNPGIFFTYRENPVLRAFEPLRSFASGGRSINVTGQGFSLIQRFAMVVIA
EPLQSWQPPREAESLQPMTVVGTDYVFHNDTKVVFLSPAVPEEPEAYNLTVLIEMDGHRA
LLRTEAGAFEYVPDPTFENFTGGVKKQVNKLIHARGTNLNKAMTLQEAEAFVGAERCTMK
TLTETDLYCEPPEVQPPPKRRQKRDTTHNLPEFIVKFGSREWVLGRVEYDTRVSDVPLSL
ILPLVIVPMVVVIAVSVYCYWRKSQQAEREYEKIKSQLEGLEESVRDRCKKEFTDLMIEM
EDQTNDVHEAGIPVLDYKTYTDRVFFLPSKDGDKDVMITGKLDIPEPRRPVVEQALYQFS
NLLNSKSFLINFIHTLENQREFSARAKVYFASLLTVALHGKLEYYTDIMHTLFLELLEQY
VVAKNPKLMLRRSETVVERMLSNWMSICLYQYLKDSAGEPLYKLFKAIKHQVEKGPVDAV
QKKAKYTLNDTGLLGDDVEYAPLTVSVIVQDEGVDAIPVKVLNCDTISQVKEKIIDQVYR
GQPCSCWPRPDSVVLEWRPGSTAQILSDLDLTSQREGRWKRVNTLMHYNVRDGATLILSK
VGVSQQPEDSQQDLPGERHALLEEENRVWHLVRPTDEVDEGKSKRGSVKEKERTKAITEI
YLTRLLSVKGTLQQFVDNFFQSVLAPGHAVPPAVKYFFDFLDEQAEKHNIQDEDTIHIWK
TNSLPLRFWVNILKNPHFIFDVHVHEVVDASLSVIAQTFMDACTRTEHKLSRDSPSNKLL
YAKEISTYKKMVEDYYKGIRQMVQVSDQDMNTHLAEISRAHTDSLNTLVALHQLYQYTQK
YYDEIINALEEDPAAQKMQLAFRLQQIAAALENKVTDL

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History
Entry version 159 (07 Nov 2018)
Sequence version 3 (20 Feb 2007)
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Protein

Plexin-B2

Gene

PLXNB2

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42. Down-regulates macrophage migration in wound-healing assays (in vitro) (By similarity).By similarity3 Publications

GO - Molecular functionⁱ

semaphorin receptor activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

brain development Source: UniProtKB
homophilic cell adhesion via plasma membrane adhesion molecules
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 16122393
negative regulation of cell adhesion
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
neural tube closure Source: UniProtKB
neuroblast proliferation Source: UniProtKB
positive regulation of axonogenesis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of neuron projection development
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 16122393
regulation of cell migration
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of cell shape Source: UniProtKB
regulation of GTPase activity Source: UniProtKB
regulation of neuron migration Source: UniProtKB
regulation of protein phosphorylation Source: UniProtKB
semaphorin-plexin signaling pathway Source: UniProtKB
semaphorin-plexin signaling pathway involved in axon guidance
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, Receptor

Molecular function

Developmental protein, Receptor

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Plexin-B2 Alternative name(s): MM1
Gene namesⁱ	Name:PLXNB2 Synonyms:KIAA0315
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 22

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000196576.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9104 PLXNB2
MIMⁱ	604293 gene
neXtProtⁱ	NX_O15031

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	20 – 1197	ExtracellularSequence analysisAdd BLAST	1178
Transmembraneⁱ	1198 – 1218	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	1219 – 1838	CytoplasmicSequence analysisAdd BLAST	620

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	1161 – 1164	RQKR → AQKA: Abolishes cleavage by proprotein convertases. 1 Publication		4

Organism-specific databases

DisGeNET More...DisGeNETⁱ	23654
Open Targets More...OpenTargetsⁱ	ENSG00000196576
PharmGKBⁱ	PA33430

Polymorphism and mutation databases

BioMutaⁱ	PLXNB2

BioMutaⁱ

PLXNB2

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 19	Sequence analysisAdd BLAST		19
ChainⁱPRO_0000024673	20 – 1838	Plexin-B2Add BLAST		1819

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	78 ↔ 87	PROSITE-ProRule annotation
Disulfide bondⁱ	112 ↔ 120	PROSITE-ProRule annotation
Glycosylationⁱ	127	N-linked (GlcNAc...) asparagine2 Publications	1
Glycosylationⁱ	242	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	250 ↔ 364	PROSITE-ProRule annotation
Disulfide bondⁱ	266 ↔ 312	PROSITE-ProRule annotation
Disulfide bondⁱ	330 ↔ 351	PROSITE-ProRule annotation
Glycosylationⁱ	391	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	402	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	469 ↔ 486	PROSITE-ProRule annotation
Disulfide bondⁱ	475 ↔ 518	PROSITE-ProRule annotation
Disulfide bondⁱ	478 ↔ 495	PROSITE-ProRule annotation
Disulfide bondⁱ	489 ↔ 501	PROSITE-ProRule annotation
Glycosylationⁱ	528	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	555 ↔ 574	PROSITE-ProRule annotation
Glycosylationⁱ	733	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	759	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	795	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	844	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	1002	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	1049	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	1068	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	1099	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	1236	PhosphoserineBy similarity	1
Modified residueⁱ	1244	PhosphoserineBy similarity	1
Modified residueⁱ	1570	PhosphoserineBy similarity	1

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	1164 – 1165	Cleavage; by proprotein convertases		2

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	O15031
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O15031
PaxDbⁱ	O15031
PeptideAtlas More...PeptideAtlasⁱ	O15031
PRIDEⁱ	O15031
ProteomicsDBⁱ	48388

PTM databases

GlyConnectⁱ	1613
iPTMnetⁱ	O15031
PhosphoSitePlusⁱ	O15031
SwissPalmⁱ	O15031

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000196576 Expressed in 218 organ(s), highest expression level in right uterine tube
CleanExⁱ	HS_PLXNB2
ExpressionAtlasⁱ	O15031 baseline and differential
Genevisibleⁱ	O15031 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA003100

HPAⁱ

HPA003100

Interactionⁱ

Subunit structureⁱ

Monomer, and heterodimer with PLXNB1. Interacts with SEMA4C, SEMA4D and SEMA4G (By similarity). Binds MET, ARHGEF11 and ARHGEF12. May also interact with MST1R.By similarity2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
MET	P08581	2	EBI-722004,EBI-1039152
MST1R	Q04912	2	EBI-722004,EBI-2637518

Protein-protein interaction databases

BioGridⁱ	117178, 42 interactors
IntActⁱ	O15031, 22 interactors
Molecular INTeraction database More...MINTⁱ	O15031
STRINGⁱ	9606.ENSP00000352288

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	1462 – 1469	Combined sources	8
Beta strandⁱ	1477 – 1482	Combined sources	6
Helixⁱ	1487 – 1498	Combined sources	12
Beta strandⁱ	1512 – 1517	Combined sources	6
Helixⁱ	1545 – 1548	Combined sources	4
Beta strandⁱ	1555 – 1560	Combined sources	6

Show more details

3D structure databases

ProteinModelPortalⁱ	O15031
SMRⁱ	O15031
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	20 – 466	SemaPROSITE-ProRule annotationAdd BLAST	447
Domainⁱ	803 – 893	IPT/TIG 1Add BLAST	91
Domainⁱ	895 – 980	IPT/TIG 2Add BLAST	86
Domainⁱ	983 – 1092	IPT/TIG 3Add BLAST	110

Sequence similaritiesⁱ

Belongs to the plexin family.Curated

Keywords - Domainⁱ

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IN3E Eukaryota ENOG411131Q LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119048
HOGENOMⁱ	HOG000231376
HOVERGENⁱ	HBG053404
InParanoidⁱ	O15031
KEGG Orthology (KO) More...KOⁱ	K06821
OMAⁱ	EDSCPQF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00EK
PhylomeDBⁱ	O15031
TreeFamⁱ	TF312962

Family and domain databases

Gene3Dⁱ	2.130.10.10, 1 hit 2.60.40.10, 3 hits
InterProⁱ	View protein in InterPro IPR013783 Ig-like_fold IPR014756 Ig_E-set IPR002909 IPT_dom IPR031148 Plexin IPR013548 Plexin_cytoplasmic_RasGAP_dom IPR002165 Plexin_repeat IPR016201 PSI IPR008936 Rho_GTPase_activation_prot IPR001627 Semap_dom IPR036352 Semap_dom_sf IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERⁱ	PTHR22625 PTHR22625, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08337 Plexin_cytopl, 1 hit PF01437 PSI, 1 hit PF01403 Sema, 1 hit PF01833 TIG, 3 hits
SMARTⁱ	View protein in SMART SM00429 IPT, 3 hits SM00423 PSI, 3 hits SM00630 Sema, 1 hit
SUPFAMⁱ	SSF101912 SSF101912, 1 hit SSF48350 SSF48350, 1 hit SSF81296 SSF81296, 3 hits
PROSITEⁱ	View protein in PROSITE PS51004 SEMA, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show all Align All

O15031-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MALQLWALTL LGLLGAGASL RPRKLDFFRS EKELNHLAVD EASGVVYLGA 
        60         70         80         90        100
VNALYQLDAK LQLEQQVATG PALDNKKCTP PIEASQCHEA EMTDNVNQLL 
       110        120        130        140        150
LLDPPRKRLV ECGSLFKGIC ALRALSNISL RLFYEDGSGE KSFVASNDEG 
       160        170        180        190        200
VATVGLVSST GPGGDRVLFV GKGNGPHDNG IIVSTRLLDR TDSREAFEAY 
       210        220        230        240        250
TDHATYKAGY LSTNTQQFVA AFEDGPYVFF VFNQQDKHPA RNRTLLARMC 
       260        270        280        290        300
REDPNYYSYL EMDLQCRDPD IHAAAFGTCL AASVAAPGSG RVLYAVFSRD 
       310        320        330        340        350
SRSSGGPGAG LCLFPLDKVH AKMEANRNAC YTGTREARDI FYKPFHGDIQ 
       360        370        380        390        400
CGGHAPGSSK SFPCGSEHLP YPLGSRDGLR GTAVLQRGGL NLTAVTVAAE 
       410        420        430        440        450
NNHTVAFLGT SDGRILKVYL TPDGTSSEYD SILVEINKRV KRDLVLSGDL 
       460        470        480        490        500
GSLYAMTQDK VFRLPVQECL SYPTCTQCRD SQDPYCGWCV VEGRCTRKAE 
       510        520        530        540        550
CPRAEEASHW LWSRSKSCVA VTSAQPQNMS RRAQGEVQLT VSPLPALSEE 
       560        570        580        590        600
DELLCLFGES PPHPARVEGE AVICNSPSSI PVTPPGQDHV AVTIQLLLRR 
       610        620        630        640        650
GNIFLTSYQY PFYDCRQAMS LEENLPCISC VSNRWTCQWD LRYHECREAS 
       660        670        680        690        700
PNPEDGIVRA HMEDSCPQFL GPSPLVIPMN HETDVNFQGK NLDTVKGSSL 
       710        720        730        740        750
HVGSDLLKFM EPVTMQESGT FAFRTPKLSH DANETLPLHL YVKSYGKNID 
       760        770        780        790        800
SKLHVTLYNC SFGRSDCSLC RAANPDYRCA WCGGQSRCVY EALCNTTSEC 
       810        820        830        840        850
PPPVITRIQP ETGPLGGGIR ITILGSNLGV QAGDIQRISV AGRNCSFQPE 
       860        870        880        890        900
RYSVSTRIVC VIEAAETPFT GGVEVDVFGK LGRSPPNVQF TFQQPKPLSV 
       910        920        930        940        950
EPQQGPQAGG TTLTIHGTHL DTGSQEDVRV TLNGVPCKVT KFGAQLQCVT 
       960        970        980        990       1000
GPQATRGQML LEVSYGGSPV PNPGIFFTYR ENPVLRAFEP LRSFASGGRS 
      1010       1020       1030       1040       1050
INVTGQGFSL IQRFAMVVIA EPLQSWQPPR EAESLQPMTV VGTDYVFHND 
      1060       1070       1080       1090       1100
TKVVFLSPAV PEEPEAYNLT VLIEMDGHRA LLRTEAGAFE YVPDPTFENF 
      1110       1120       1130       1140       1150
TGGVKKQVNK LIHARGTNLN KAMTLQEAEA FVGAERCTMK TLTETDLYCE 
      1160       1170       1180       1190       1200
PPEVQPPPKR RQKRDTTHNL PEFIVKFGSR EWVLGRVEYD TRVSDVPLSL 
      1210       1220       1230       1240       1250
ILPLVIVPMV VVIAVSVYCY WRKSQQAERE YEKIKSQLEG LEESVRDRCK 
      1260       1270       1280       1290       1300
KEFTDLMIEM EDQTNDVHEA GIPVLDYKTY TDRVFFLPSK DGDKDVMITG 
      1310       1320       1330       1340       1350
KLDIPEPRRP VVEQALYQFS NLLNSKSFLI NFIHTLENQR EFSARAKVYF 
      1360       1370       1380       1390       1400
ASLLTVALHG KLEYYTDIMH TLFLELLEQY VVAKNPKLML RRSETVVERM 
      1410       1420       1430       1440       1450
LSNWMSICLY QYLKDSAGEP LYKLFKAIKH QVEKGPVDAV QKKAKYTLND 
      1460       1470       1480       1490       1500
TGLLGDDVEY APLTVSVIVQ DEGVDAIPVK VLNCDTISQV KEKIIDQVYR 
      1510       1520       1530       1540       1550
GQPCSCWPRP DSVVLEWRPG STAQILSDLD LTSQREGRWK RVNTLMHYNV 
      1560       1570       1580       1590       1600
RDGATLILSK VGVSQQPEDS QQDLPGERHA LLEEENRVWH LVRPTDEVDE 
      1610       1620       1630       1640       1650
GKSKRGSVKE KERTKAITEI YLTRLLSVKG TLQQFVDNFF QSVLAPGHAV 
      1660       1670       1680       1690       1700
PPAVKYFFDF LDEQAEKHNI QDEDTIHIWK TNSLPLRFWV NILKNPHFIF 
      1710       1720       1730       1740       1750
DVHVHEVVDA SLSVIAQTFM DACTRTEHKL SRDSPSNKLL YAKEISTYKK 
      1760       1770       1780       1790       1800
MVEDYYKGIR QMVQVSDQDM NTHLAEISRA HTDSLNTLVA LHQLYQYTQK 
      1810       1820       1830 
YYDEIINALE EDPAAQKMQL AFRLQQIAAA LENKVTDL

Length:1,838

Mass (Da):205,127

Last modified:February 20, 2007 - v3

Checksum:ⁱ4AE43003828BC769

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E2PU09	E2PU09_HUMAN	Plexin-B2 Plexin-B2	PLXNB2	477	Annotation score:
A6QRH1	A6QRH1_HUMAN	Plexin-B2 Plexin-B2	PLXNB2	161	Annotation score:
A6QRG9	A6QRG9_HUMAN	Plexin-B2 Plexin-B2	PLXNB2	234	Annotation score:
H0Y6J7	H0Y6J7_HUMAN	Plexin-B2 Plexin-B2	PLXNB2	189	Annotation score:
A0A087WU36	A0A087WU36_HUMAN	Plexin-B2 Plexin-B2	PLXNB2	347	Annotation score:
H0Y7X5	H0Y7X5_HUMAN	Plexin-B2 Plexin-B2	PLXNB2	84	Annotation score:
A0A087X000	A0A087X000_HUMAN	Plexin-B2 Plexin-B2	PLXNB2	160	Annotation score:

Sequence cautionⁱ

The sequence BAA21571 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	1535	R → Q in AAH04542 (PubMed:15489334).Curated		1
Sequence conflictⁱ	1535	R → Q in AAP35533 (Ref. 4) Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_050600	318	K → ECombined sourcesCorresponds to variant dbSNP:rs28379706Ensembl.		1
Natural variantⁱVAR_061537	823	I → V. Corresponds to variant dbSNP:rs11547731Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB002313 mRNA Translation: BAA21571.1 Different initiation. AL022328 Genomic DNA No translation available. BX649592 Genomic DNA No translation available. BC004542 mRNA Translation: AAH04542.2 BT006887 mRNA Translation: AAP35533.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS43035.1
NCBI Reference Sequences More...RefSeqⁱ	NP_036533.2, NM_012401.3 XP_005261966.1, XM_005261909.1 XP_005261967.1, XM_005261910.2 XP_005261968.1, XM_005261911.4 XP_006724476.1, XM_006724413.2 XP_016884192.1, XM_017028703.1 XP_016884193.1, XM_017028704.1
UniGeneⁱ	Hs.3989 Hs.736016

Genome annotation databases

Ensemblⁱ	ENST00000359337; ENSP00000352288; ENSG00000196576 ENST00000449103; ENSP00000409171; ENSG00000196576
GeneIDⁱ	23654
KEGGⁱ	hsa:23654
UCSC genome browser More...UCSCⁱ	uc003bkv.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O15031	PLXNB2 isoform 14 (Fragment)		PONAB		162	UniRef100_O15031
Plexin-B2 (Fragment)		HUMAN		477
Plexin-B2		PANTR		630
PLXNB2 protein (Fragment)		HUMAN		281
Plexin-B2 (Fragment)		HUMAN		161
+1

Protein	Similar proteins		Species	Score	Length	Source
O15031	PLXNB2 isoform 14 (Fragment)		PONAB		162	UniRef90_O15031
Plexin-B2 (Fragment)		HUMAN		477
Plexin-B2		PANTR		630
Uncharacterized protein		AOTNA		1878
Uncharacterized protein		MACFA		1855
+50

Protein	Similar proteins		Species	Score	Length	Source
O15031	Plexin-B2	)	MOUSE		1842	UniRef50_B2RXS4
plexin-B2		DIPOR		1841
Plexin B2		RAT		1841
plexin-B2		MESAU		1841
Uncharacterized protein		NEOLE		1813
+305

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB002313 mRNA Translation: BAA21571.1 Different initiation. AL022328 Genomic DNA No translation available. BX649592 Genomic DNA No translation available. BC004542 mRNA Translation: AAH04542.2 BT006887 mRNA Translation: AAP35533.1
CCDSⁱ	CCDS43035.1
RefSeqⁱ	NP_036533.2, NM_012401.3 XP_005261966.1, XM_005261909.1 XP_005261967.1, XM_005261910.2 XP_005261968.1, XM_005261911.4 XP_006724476.1, XM_006724413.2 XP_016884192.1, XM_017028703.1 XP_016884193.1, XM_017028704.1
UniGeneⁱ	Hs.3989 Hs.736016

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4E71	X-ray	2.26	A	1452-1562	[»]
ProteinModelPortalⁱ	O15031
SMRⁱ	O15031
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117178, 42 interactors
IntActⁱ	O15031, 22 interactors
MINTⁱ	O15031
STRINGⁱ	9606.ENSP00000352288

PTM databases

GlyConnectⁱ	1613
iPTMnetⁱ	O15031
PhosphoSitePlusⁱ	O15031
SwissPalmⁱ	O15031

Polymorphism and mutation databases

BioMutaⁱ	PLXNB2

BioMutaⁱ

PLXNB2

Proteomic databases

EPDⁱ	O15031
MaxQBⁱ	O15031
PaxDbⁱ	O15031
PeptideAtlasⁱ	O15031
PRIDEⁱ	O15031
ProteomicsDBⁱ	48388

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	23654
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000359337; ENSP00000352288; ENSG00000196576 ENST00000449103; ENSP00000409171; ENSG00000196576
GeneIDⁱ	23654
KEGGⁱ	hsa:23654
UCSCⁱ	uc003bkv.4 human

Organism-specific databases

CTDⁱ	23654
DisGeNETⁱ	23654
EuPathDBⁱ	HostDB:ENSG00000196576.14
GeneCardsⁱ	PLXNB2
HGNCⁱ	HGNC:9104 PLXNB2
HPAⁱ	HPA003100
MIMⁱ	604293 gene
neXtProtⁱ	NX_O15031
OpenTargetsⁱ	ENSG00000196576
PharmGKBⁱ	PA33430
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IN3E Eukaryota ENOG411131Q LUCA
GeneTreeⁱ	ENSGT00760000119048
HOGENOMⁱ	HOG000231376
HOVERGENⁱ	HBG053404
InParanoidⁱ	O15031
KOⁱ	K06821
OMAⁱ	EDSCPQF
OrthoDBⁱ	EOG091G00EK
PhylomeDBⁱ	O15031
TreeFamⁱ	TF312962

Miscellaneous databases

ChiTaRSⁱ	PLXNB2 human
GeneWikiⁱ	PLXNB2
GenomeRNAiⁱ	23654
Protein Ontology More...PROⁱ	PR:O15031
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000196576 Expressed in 218 organ(s), highest expression level in right uterine tube
CleanExⁱ	HS_PLXNB2
ExpressionAtlasⁱ	O15031 baseline and differential
Genevisibleⁱ	O15031 HS

Family and domain databases

Gene3Dⁱ	2.130.10.10, 1 hit 2.60.40.10, 3 hits
InterProⁱ	View protein in InterPro IPR013783 Ig-like_fold IPR014756 Ig_E-set IPR002909 IPT_dom IPR031148 Plexin IPR013548 Plexin_cytoplasmic_RasGAP_dom IPR002165 Plexin_repeat IPR016201 PSI IPR008936 Rho_GTPase_activation_prot IPR001627 Semap_dom IPR036352 Semap_dom_sf IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERⁱ	PTHR22625 PTHR22625, 1 hit
Pfamⁱ	View protein in Pfam PF08337 Plexin_cytopl, 1 hit PF01437 PSI, 1 hit PF01403 Sema, 1 hit PF01833 TIG, 3 hits
SMARTⁱ	View protein in SMART SM00429 IPT, 3 hits SM00423 PSI, 3 hits SM00630 Sema, 1 hit
SUPFAMⁱ	SSF101912 SSF101912, 1 hit SSF48350 SSF48350, 1 hit SSF81296 SSF81296, 3 hits
PROSITEⁱ	View protein in PROSITE PS51004 SEMA, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PLXB2_HUMAN
Accessionⁱ	O15031Primary (citable) accession number: O15031 Secondary accession number(s): A6QRH0, Q7KZU3, Q9BSU7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
	Last sequence update:	February 20, 2007
	Last modified:	November 7, 2018
	This is version 159 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - O15031 (PLXB2_HUMAN)

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Plexin-B2

PLXNB2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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Plasma Membrane

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Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

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<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Sites

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ