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UniProtKB - O15031 (PLXB2_HUMAN)

Entry version 180 (25 May 2022)
Sequence version 3 (20 Feb 2007)
Previous versions | rss
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Protein

Plexin-B2

Gene

PLXNB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling (By similarity).

Plays a role in glutamatergic synapse development and is required for SEMA4A-mediated excitatory synapse development (By similarity).

Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248' (By similarity).

Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development (By similarity).

Regulates the migration of cerebellar granule cells in the developing brain (By similarity).

Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton (PubMed:12183458).

Plays a role in axon guidance, invasive growth and cell migration (PubMed:15184888).

May modulate the activity of RAC1 and CDC42 (By similarity).

By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Receptor

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O15031

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O15031

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Plexin-B2
Alternative name(s):
MM1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLXNB2
Synonyms:KIAA0315
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9104, PLXNB2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604293, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O15031

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000196576

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini20 – 1197ExtracellularSequence analysisAdd BLAST1178
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1198 – 1218HelicalSequence analysisAdd BLAST21
Topological domaini1219 – 1838CytoplasmicSequence analysisAdd BLAST620

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1161 – 1164RQKR → AQKA: Abolishes cleavage by proprotein convertases. 1 Publication4

Organism-specific databases

DisGeNET

More...DisGeNETi		23654

Open Targets

More...OpenTargetsi		ENSG00000196576

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33430

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O15031, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PLXNB2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002467320 – 1838Plexin-B2Add BLAST1819

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi78 ↔ 87PROSITE-ProRule annotation
Disulfide bondi112 ↔ 120PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi127N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi242N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi250 ↔ 364PROSITE-ProRule annotation
Disulfide bondi266 ↔ 312PROSITE-ProRule annotation
Disulfide bondi330 ↔ 351PROSITE-ProRule annotation
Glycosylationi391N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi402N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi469 ↔ 486PROSITE-ProRule annotation
Disulfide bondi475 ↔ 518PROSITE-ProRule annotation
Disulfide bondi478 ↔ 495PROSITE-ProRule annotation
Disulfide bondi489 ↔ 501PROSITE-ProRule annotation
Glycosylationi528N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi555 ↔ 574PROSITE-ProRule annotation
Glycosylationi733N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi759N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi795N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi844N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1002N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1049N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1068N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1099N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1236PhosphoserineBy similarity1
Modified residuei1244PhosphoserineBy similarity1
Modified residuei1570PhosphoserineBy similarity1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei1164 – 1165Cleavage; by proprotein convertases2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-1504
CPTAC-2603

Encyclopedia of Proteome Dynamics

More...EPDi		O15031

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O15031

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O15031

MaxQB - The MaxQuant DataBase

More...MaxQBi		O15031

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O15031

PeptideAtlas

More...PeptideAtlasi		O15031

PRoteomics IDEntifications database

More...PRIDEi		O15031

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		48388

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1613, 57 N-Linked glycans (11 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O15031, 16 sites, 56 N-linked glycans (11 sites), 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O15031

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O15031

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O15031

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000196576, Expressed in right uterine tube and 229 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O15031, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O15031, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000196576, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer, and heterodimer with PLXNB1 (PubMed:12533544).

Interacts with SEMA4C, SEMA4D and SEMA4G (By similarity).

Interacts with MET (PubMed:15184888).

Interacts with ARHGEF11 and ARHGEF12 (PubMed:12183458). May also interact with MST1R (PubMed:15184888).

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		117178, 199 interactors

Protein interaction database and analysis system

More...IntActi		O15031, 44 interactors

Molecular INTeraction database

More...MINTi		O15031

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000409171

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O15031, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11838
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		O15031

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O15031

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 466SemaPROSITE-ProRule annotationAdd BLAST447
Domaini803 – 893IPT/TIG 1Add BLAST91
Domaini895 – 980IPT/TIG 2Add BLAST86
Domaini983 – 1092IPT/TIG 3Add BLAST110

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the plexin family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3610, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01020000230394

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001436_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O15031

Identification of Orthologs from Complete Genome Data

More...OMAi		CTPPIDE

Database of Orthologous Groups

More...OrthoDBi		90434at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O15031

TreeFam database of animal gene trees

More...TreeFami		TF312962

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.506.10, 1 hit
2.130.10.10, 1 hit
2.60.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR002909, IPT_dom
IPR031148, Plexin
IPR013548, Plexin_cytoplasmic_RasGAP_dom
IPR002165, Plexin_repeat
IPR016201, PSI
IPR008936, Rho_GTPase_activation_prot
IPR001627, Semap_dom
IPR036352, Semap_dom_sf
IPR041019, TIG1_plexin
IPR015943, WD40/YVTN_repeat-like_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR22625, PTHR22625, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08337, Plexin_cytopl, 1 hit
PF01437, PSI, 1 hit
PF01403, Sema, 1 hit
PF01833, TIG, 3 hits
PF17960, TIG_plexin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00429, IPT, 3 hits
SM00423, PSI, 3 hits
SM00630, Sema, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF101912, SSF101912, 1 hit
SSF48350, SSF48350, 1 hit
SSF81296, SSF81296, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51004, SEMA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

O15031-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALQLWALTL LGLLGAGASL RPRKLDFFRS EKELNHLAVD EASGVVYLGA 
        60         70         80         90        100
VNALYQLDAK LQLEQQVATG PALDNKKCTP PIEASQCHEA EMTDNVNQLL 
       110        120        130        140        150
LLDPPRKRLV ECGSLFKGIC ALRALSNISL RLFYEDGSGE KSFVASNDEG 
       160        170        180        190        200
VATVGLVSST GPGGDRVLFV GKGNGPHDNG IIVSTRLLDR TDSREAFEAY 
       210        220        230        240        250
TDHATYKAGY LSTNTQQFVA AFEDGPYVFF VFNQQDKHPA RNRTLLARMC 
       260        270        280        290        300
REDPNYYSYL EMDLQCRDPD IHAAAFGTCL AASVAAPGSG RVLYAVFSRD 
       310        320        330        340        350
SRSSGGPGAG LCLFPLDKVH AKMEANRNAC YTGTREARDI FYKPFHGDIQ 
       360        370        380        390        400
CGGHAPGSSK SFPCGSEHLP YPLGSRDGLR GTAVLQRGGL NLTAVTVAAE 
       410        420        430        440        450
NNHTVAFLGT SDGRILKVYL TPDGTSSEYD SILVEINKRV KRDLVLSGDL 
       460        470        480        490        500
GSLYAMTQDK VFRLPVQECL SYPTCTQCRD SQDPYCGWCV VEGRCTRKAE 
       510        520        530        540        550
CPRAEEASHW LWSRSKSCVA VTSAQPQNMS RRAQGEVQLT VSPLPALSEE 
       560        570        580        590        600
DELLCLFGES PPHPARVEGE AVICNSPSSI PVTPPGQDHV AVTIQLLLRR 
       610        620        630        640        650
GNIFLTSYQY PFYDCRQAMS LEENLPCISC VSNRWTCQWD LRYHECREAS 
       660        670        680        690        700
PNPEDGIVRA HMEDSCPQFL GPSPLVIPMN HETDVNFQGK NLDTVKGSSL 
       710        720        730        740        750
HVGSDLLKFM EPVTMQESGT FAFRTPKLSH DANETLPLHL YVKSYGKNID 
       760        770        780        790        800
SKLHVTLYNC SFGRSDCSLC RAANPDYRCA WCGGQSRCVY EALCNTTSEC 
       810        820        830        840        850
PPPVITRIQP ETGPLGGGIR ITILGSNLGV QAGDIQRISV AGRNCSFQPE 
       860        870        880        890        900
RYSVSTRIVC VIEAAETPFT GGVEVDVFGK LGRSPPNVQF TFQQPKPLSV 
       910        920        930        940        950
EPQQGPQAGG TTLTIHGTHL DTGSQEDVRV TLNGVPCKVT KFGAQLQCVT 
       960        970        980        990       1000
GPQATRGQML LEVSYGGSPV PNPGIFFTYR ENPVLRAFEP LRSFASGGRS 
      1010       1020       1030       1040       1050
INVTGQGFSL IQRFAMVVIA EPLQSWQPPR EAESLQPMTV VGTDYVFHND 
      1060       1070       1080       1090       1100
TKVVFLSPAV PEEPEAYNLT VLIEMDGHRA LLRTEAGAFE YVPDPTFENF 
      1110       1120       1130       1140       1150
TGGVKKQVNK LIHARGTNLN KAMTLQEAEA FVGAERCTMK TLTETDLYCE 
      1160       1170       1180       1190       1200
PPEVQPPPKR RQKRDTTHNL PEFIVKFGSR EWVLGRVEYD TRVSDVPLSL 
      1210       1220       1230       1240       1250
ILPLVIVPMV VVIAVSVYCY WRKSQQAERE YEKIKSQLEG LEESVRDRCK 
      1260       1270       1280       1290       1300
KEFTDLMIEM EDQTNDVHEA GIPVLDYKTY TDRVFFLPSK DGDKDVMITG 
      1310       1320       1330       1340       1350
KLDIPEPRRP VVEQALYQFS NLLNSKSFLI NFIHTLENQR EFSARAKVYF 
      1360       1370       1380       1390       1400
ASLLTVALHG KLEYYTDIMH TLFLELLEQY VVAKNPKLML RRSETVVERM 
      1410       1420       1430       1440       1450
LSNWMSICLY QYLKDSAGEP LYKLFKAIKH QVEKGPVDAV QKKAKYTLND 
      1460       1470       1480       1490       1500
TGLLGDDVEY APLTVSVIVQ DEGVDAIPVK VLNCDTISQV KEKIIDQVYR 
      1510       1520       1530       1540       1550
GQPCSCWPRP DSVVLEWRPG STAQILSDLD LTSQREGRWK RVNTLMHYNV 
      1560       1570       1580       1590       1600
RDGATLILSK VGVSQQPEDS QQDLPGERHA LLEEENRVWH LVRPTDEVDE 
      1610       1620       1630       1640       1650
GKSKRGSVKE KERTKAITEI YLTRLLSVKG TLQQFVDNFF QSVLAPGHAV 
      1660       1670       1680       1690       1700
PPAVKYFFDF LDEQAEKHNI QDEDTIHIWK TNSLPLRFWV NILKNPHFIF 
      1710       1720       1730       1740       1750
DVHVHEVVDA SLSVIAQTFM DACTRTEHKL SRDSPSNKLL YAKEISTYKK 
      1760       1770       1780       1790       1800
MVEDYYKGIR QMVQVSDQDM NTHLAEISRA HTDSLNTLVA LHQLYQYTQK 
      1810       1820       1830 
YYDEIINALE EDPAAQKMQL AFRLQQIAAA LENKVTDL
Length:1,838
Mass (Da):205,127
Last modified:February 20, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4AE43003828BC769
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E2PU09E2PU09_HUMAN
Plexin-B2
PLXNB2
477Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A6QRH1A6QRH1_HUMAN
Plexin-B2
PLXNB2
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y6J7H0Y6J7_HUMAN
Plexin-B2
PLXNB2
189Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A6QRG9A6QRG9_HUMAN
Plexin-B2
PLXNB2
234Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y7X5H0Y7X5_HUMAN
Plexin-B2
PLXNB2
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA21571 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1535R → Q in AAH04542 (PubMed:15489334).Curated1
Sequence conflicti1535R → Q in AAP35533 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050600318K → ECombined sourcesCorresponds to variant dbSNP:rs28379706Ensembl.1
Natural variantiVAR_061537823I → V. Corresponds to variant dbSNP:rs11547731Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB002313 mRNA Translation: BAA21571.1 Different initiation.
AL022328 Genomic DNA No translation available.
BX649592 Genomic DNA No translation available.
BC004542 mRNA Translation: AAH04542.2
BT006887 mRNA Translation: AAP35533.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS43035.1

NCBI Reference Sequences

More...RefSeqi		NP_036533.2, NM_012401.3
XP_005261966.1, XM_005261909.1
XP_005261967.1, XM_005261910.2
XP_005261968.1, XM_005261911.4
XP_006724476.1, XM_006724413.2
XP_016884192.1, XM_017028703.1
XP_016884193.1, XM_017028704.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000359337.9; ENSP00000352288.4; ENSG00000196576.16
ENST00000449103.5; ENSP00000409171.1; ENSG00000196576.16

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23654

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23654

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000359337.9; ENSP00000352288.4; NM_012401.4; NP_036533.2

UCSC genome browser

More...UCSCi		uc003bkv.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002313 mRNA Translation: BAA21571.1 Different initiation.
AL022328 Genomic DNA No translation available.
BX649592 Genomic DNA No translation available.
BC004542 mRNA Translation: AAH04542.2
BT006887 mRNA Translation: AAP35533.1
CCDSiCCDS43035.1
RefSeqiNP_036533.2, NM_012401.3
XP_005261966.1, XM_005261909.1
XP_005261967.1, XM_005261910.2
XP_005261968.1, XM_005261911.4
XP_006724476.1, XM_006724413.2
XP_016884192.1, XM_017028703.1
XP_016884193.1, XM_017028704.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4E71X-ray2.26A1452-1562[»]
AlphaFoldDBiO15031
SMRiO15031
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi117178, 199 interactors
IntActiO15031, 44 interactors
MINTiO15031
STRINGi9606.ENSP00000409171

PTM databases

GlyConnecti1613, 57 N-Linked glycans (11 sites)
GlyGeniO15031, 16 sites, 56 N-linked glycans (11 sites), 1 O-linked glycan (1 site)
iPTMnetiO15031
PhosphoSitePlusiO15031
SwissPalmiO15031

Genetic variation databases

BioMutaiPLXNB2

Proteomic databases

CPTACiCPTAC-1504
CPTAC-2603
EPDiO15031
jPOSTiO15031
MassIVEiO15031
MaxQBiO15031
PaxDbiO15031
PeptideAtlasiO15031
PRIDEiO15031
ProteomicsDBi48388

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		322, 151 antibodies from 22 providers

The DNASU plasmid repository

More...DNASUi		23654

Genome annotation databases

EnsembliENST00000359337.9; ENSP00000352288.4; ENSG00000196576.16
ENST00000449103.5; ENSP00000409171.1; ENSG00000196576.16
GeneIDi23654
KEGGihsa:23654
MANE-SelectiENST00000359337.9; ENSP00000352288.4; NM_012401.4; NP_036533.2
UCSCiuc003bkv.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23654
DisGeNETi23654

GeneCards: human genes, protein and diseases

More...GeneCardsi		PLXNB2
HGNCiHGNC:9104, PLXNB2
HPAiENSG00000196576, Low tissue specificity
MIMi604293, gene
neXtProtiNX_O15031
OpenTargetsiENSG00000196576
PharmGKBiPA33430
VEuPathDBiHostDB:ENSG00000196576

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3610, Eukaryota
GeneTreeiENSGT01020000230394
HOGENOMiCLU_001436_1_0_1
InParanoidiO15031
OMAiCTPPIDE
OrthoDBi90434at2759
PhylomeDBiO15031
TreeFamiTF312962

Enzyme and pathway databases

PathwayCommonsiO15031
SignaLinkiO15031

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		23654, 23 hits in 1077 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PLXNB2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PLXNB2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23654
PharosiO15031, Tbio

Protein Ontology

More...PROi		PR:O15031
RNActiO15031, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000196576, Expressed in right uterine tube and 229 other tissues
ExpressionAtlasiO15031, baseline and differential
GenevisibleiO15031, HS

Family and domain databases

Gene3Di1.10.506.10, 1 hit
2.130.10.10, 1 hit
2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR002909, IPT_dom
IPR031148, Plexin
IPR013548, Plexin_cytoplasmic_RasGAP_dom
IPR002165, Plexin_repeat
IPR016201, PSI
IPR008936, Rho_GTPase_activation_prot
IPR001627, Semap_dom
IPR036352, Semap_dom_sf
IPR041019, TIG1_plexin
IPR015943, WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR22625, PTHR22625, 1 hit
PfamiView protein in Pfam
PF08337, Plexin_cytopl, 1 hit
PF01437, PSI, 1 hit
PF01403, Sema, 1 hit
PF01833, TIG, 3 hits
PF17960, TIG_plexin, 1 hit
SMARTiView protein in SMART
SM00429, IPT, 3 hits
SM00423, PSI, 3 hits
SM00630, Sema, 1 hit
SUPFAMiSSF101912, SSF101912, 1 hit
SSF48350, SSF48350, 1 hit
SSF81296, SSF81296, 3 hits
PROSITEiView protein in PROSITE
PS51004, SEMA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLXB2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15031
Secondary accession number(s): A6QRH0, Q7KZU3, Q9BSU7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: February 20, 2007
Last modified: May 25, 2022
This is version 180 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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