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UniProtKB - O15027 (SC16A_HUMAN)

Entry version 174 (22 Apr 2020)
Sequence version 4 (07 Nov 2018)
Previous versions | rss
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Protein

Protein transport protein Sec16A

Gene

SEC16A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17192411, PubMed:17005010, PubMed:17428803, PubMed:21768384, PubMed:22355596). Mediates the recruitment of MIA3/TANGO to ERES (PubMed:28442536). Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane (PubMed:28067262). Positively regulates the protein stability of E3 ubiquitin-protein ligases RNF152 and RNF183 and the ER localization of RNF183 (PubMed:29300766). Acts as a RAB10 effector in the regulation of insulin-induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the cell membrane in adipocytes (By similarity).By similarity8 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-204005 COPII-mediated vesicle transport

SIGNOR Signaling Network Open Resource

More...SIGNORi		O15027

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein transport protein Sec16A
Alternative name(s):
SEC16 homolog A
Short name:
p2501 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SEC16A
Synonyms:KIAA0310, SEC16, SEC16L
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:29006 SEC16A

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		612854 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O15027

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Membrane, Microsome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		9919

Open Targets

More...OpenTargetsi		ENSG00000148396

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162402611

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O15027 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SEC16A

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000507461 – 2357Protein transport protein Sec16AAdd BLAST2357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei296PhosphoserineCombined sources1
Modified residuei314PhosphoserineCombined sources1
Modified residuei331PhosphoserineCombined sources1
Modified residuei559PhosphoserineCombined sources1
Modified residuei569PhosphoserineCombined sources1
Modified residuei587PhosphoserineCombined sources1
Modified residuei589PhosphoserineCombined sources1
Modified residuei592PhosphoserineCombined sources1
Modified residuei593PhosphothreonineCombined sources1
Modified residuei595PhosphoserineCombined sources1
Modified residuei1069PhosphoserineCombined sources1
Modified residuei1207PhosphoserineCombined sources1
Modified residuei1229PhosphoserineCombined sources1
Modified residuei1305PhosphoserineCombined sources1
Modified residuei1325PhosphothreonineCombined sources1
Modified residuei1327PhosphoserineCombined sources1
Modified residuei1347PhosphoserineCombined sources1
Modified residuei1350PhosphoserineCombined sources1
Modified residuei1356PhosphoserineCombined sources1
Modified residuei1359PhosphoserineCombined sources1
Modified residuei1362PhosphoserineCombined sources1
Modified residuei1369PhosphoserineCombined sources1
Modified residuei1573PhosphoserineCombined sources1
Modified residuei1601PhosphoserineCombined sources1
Modified residuei1907PhosphothreonineCombined sources1
Modified residuei1939PhosphoserineCombined sources1
Modified residuei1964PhosphoserineCombined sources1
Modified residuei2022PhosphoserineCombined sources1
Modified residuei2042PhosphoserineCombined sources1
Modified residuei2054PhosphothreonineCombined sources1
Modified residuei2056PhosphoserineCombined sources1
Modified residuei2073PhosphoserineCombined sources1
Modified residuei2083PhosphoserineCombined sources1
Modified residuei2271PhosphoserineCombined sources1
Modified residuei2291PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O15027

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O15027

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O15027

MaxQB - The MaxQuant DataBase

More...MaxQBi		O15027

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O15027

PeptideAtlas

More...PeptideAtlasi		O15027

PRoteomics IDEntifications database

More...PRIDEi		O15027

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		48383 [O15027-1]
48384 [O15027-2]
48385 [O15027-3]
48386 [O15027-4]
48387 [O15027-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O15027

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O15027

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Expressed at higher levels in the pancreas.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000148396 Expressed in adenohypophysis and 228 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O15027 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O15027 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000148396 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

SEC16A and SEC16B are each present in multiple copies in a heteromeric complex (PubMed:17192411, PubMed:22355596).

Interacts with SEC23A (PubMed:17192411, PubMed:17428803).

Interacts with RNF183 and RNF152 (PubMed:29300766).

Interacts with LRRK2 (via ROC domain) (PubMed:25201882).

Interacts with SEC13 (PubMed:25201882, PubMed:19638414, PubMed:17428803).

Interacts with RAB10 (By similarity).

Interacts with MIA3 (PubMed:28442536).

Interacts with GORASP2 in response to ER stress (PubMed:28067262).

By similarity8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		115247, 229 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		O15027

Database of interacting proteins

More...DIPi		DIP-27588N

Protein interaction database and analysis system

More...IntActi		O15027, 195 interactors

Molecular INTeraction database

More...MINTi		O15027

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000325827

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O15027 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O15027

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1019 – 1890Required for localization to endoplasmic reticulum exit sites1 PublicationAdd BLAST872
Regioni1101 – 1400Interaction with MIA31 PublicationAdd BLAST300
Regioni1102 – 1405Required for endoplasmic reticulum localization1 PublicationAdd BLAST304
Regioni1434 – 1890Central conserved domain (CCD); mediates interaction with RNF183, LRRK2 and SEC133 PublicationsAdd BLAST457
Regioni2106 – 2357Required for interaction with SEC23A1 PublicationAdd BLAST252

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1113 – 1181Pro-richAdd BLAST69
Compositional biasi1159 – 1162Poly-Tyr4
Compositional biasi1591 – 1594Poly-Glu4
Compositional biasi1931 – 2285Pro-richAdd BLAST355

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SEC16 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1913 Eukaryota
ENOG4111J6D LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159324

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001465_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O15027

KEGG Orthology (KO)

More...KOi		K20353

Identification of Orthologs from Complete Genome Data

More...OMAi		AAHICFI

Database of Orthologous Groups

More...OrthoDBi		235062at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O15027

TreeFam database of animal gene trees

More...TreeFami		TF316276

Family and domain databases

Conserved Domains Database

More...CDDi		cd09233 ACE1-Sec16-like, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR024298 ACE1_Sec16_Sec31
IPR024880 Sec16
IPR024340 Sec16_CCD

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12932 Sec16, 1 hit
PF12931 Sec16_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O15027-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQPPPQTVPS GMAGPPPAGN PRSVFWASSP YRRRANNNAA VAPTTCPLQP 
        60         70         80         90        100
VTDPFAFSRQ ALQSTPLGSS SKSSPPVLQG PAPAGFSQHP GLLVPHTHAR 
       110        120        130        140        150
DSSQGPCEPL PGPLTQPRAH ASPFSGALTP SAPPGPEMNR SAEVGPSSEP 
       160        170        180        190        200
EVQTLPYLPH YIPGVDPETS HGGHPHGNMP GLDRPLSRQN PHDGVVTPAA 
       210        220        230        240        250
SPSLPQPGLQ MPGQWGPVQG GPQPSGQHRS PCPEGPVPSG VPCATSVPHF 
       260        270        280        290        300
PTPSILHQGP GHEQHSPLVA PPAALPSDGR DEVSHLQSGS HLANNSDPES 
       310        320        330        340        350
TFRQNPRIVN HWASPELRQN PGVKNEHRPA SALVNPLARG DSPENRTHHP 
       360        370        380        390        400
LGAGAGSGCA PLEADSGASG ALAMFFQGGE TENEENLSSE KAGLSGQADF 
       410        420        430        440        450
DDFCSSPGLG RPPAPTHVGA GSLCQALLPG PSNEAAGDVW GDTASTGVPD 
       460        470        480        490        500
ASGSQYENVE NLEFVQNQEV LPSEPLNLDP SSPSDQFRYG PLPGPAVPRH 
       510        520        530        540        550
GAVCHTGAPD ATLHTVHPDS VSSSYSSRSH GRLSGSARPQ ELVGTFIQQE 
       560        570        580        590        600
VGKPEDEASG SFFKQIDSSP VGGETDETTV SQNYRGSVSQ PSTPSPPKPT 
       610        620        630        640        650
GIFQTSANSS FEPVKSHLVG VKPFEADRAN VVGEVRETCV RQKQCRPAAA 
       660        670        680        690        700
LPDASPGNLE QPPDNMETLC APQVCPLPLN STTEAVHMLP HAGAPPLDTV 
       710        720        730        740        750
YPAPEKRPSA RTQGPVKCES PATTLWAQSE LPDFGGNVLL APAAPALYVC 
       760        770        780        790        800
AKPQPPVVQP PEEAMSGQQS RNPSSAAPVQ SRGGIGASEN LENPPKMGEE 
       810        820        830        840        850
EALQSQASSG YASLLSSPPT ESLQNPPVLI AQPDHSYNLA QPINFSVSLS 
       860        870        880        890        900
NSHEKNQSWR EALVGDRPAV SSWALGGDSG ENTSLSGIPT SSVLSLSLPS 
       910        920        930        940        950
SVAQSNFPQG SGASEMVSNQ PANLLVQPPS QPVPENLVPE SQKDRKAGSA 
       960        970        980        990       1000
LPGFANSPAG STSVVLVPPA HGTLVPDGNK ANHSSHQEDT YGALDFTLSR 
      1010       1020       1030       1040       1050
TLENPVNVYN PSHSDSLASQ QSVASHPRQS GPGAPNLDRF YQQVTKDAQG 
      1060       1070       1080       1090       1100
QPGLERAQQE LVPPQQQASP PQLPKAMFSE LSNPESLPAQ GQAQNSAQSP 
      1110       1120       1130       1140       1150
ASLVLVDAGQ QLPPRPPQSS SVSLVSSGSG QAAVPSEQPW PQPVPALAPG 
      1160       1170       1180       1190       1200
PPPQDLAAYY YYRPLYDAYQ PQYSLPYPPE PGAASLYYQD VYSLYEPRYR 
      1210       1220       1230       1240       1250
PYDGAASAYA QNYRYPEPER PSSRASHSSE RPPPRQGYPE GYYSSKSGWS 
      1260       1270       1280       1290       1300
SQSDYYASYY SSQYDYGDPG HWDRYHYSAR VRDPRTYDRR YWCDAEYDAY 
      1310       1320       1330       1340       1350
RREHSAFGDR PEKRDNNWRY DPRFTGSFDD DPDPHRDPYG EEVDRRSVHS 
      1360       1370       1380       1390       1400
EHSARSLHSA HSLASRRSSL SSHSHQSQIY RSHNVAAGSY EAPLPPGSFH 
      1410       1420       1430       1440       1450
GDFAYGTYRS NFSSGPGFPE YGYPADTVWP AMEQVSSRPT SPEKFSVPHV 
      1460       1470       1480       1490       1500
CARFGPGGQL IKVIPNLPSE GQPALVEVHS MEALLQHTSE QEEMRAFPGP 
      1510       1520       1530       1540       1550
LAKDDTHKVD VINFAQNKAM KCLQNENLID KESASLLWNF IVLLCRQNGT 
      1560       1570       1580       1590       1600
VVGTDIAELL LRDHRTVWLP GKSPNEANLI DFTNEAVEQV EEEESGEAQL 
      1610       1620       1630       1640       1650
SFLTGGPAAA ASSLERETER FRELLLYGRK KDALESAMKN GLWGHALLLA 
      1660       1670       1680       1690       1700
SKMDSRTHAR VMTRFANSLP INDPLQTVYQ LMSGRMPAAS TCCGDEKWGD 
      1710       1720       1730       1740       1750
WRPHLAMVLS NLNNNMDVES RTMATMGDTL ASRGLLDAAH FCYLMAQAGF 
      1760       1770       1780       1790       1800
GVYTKKTTKL VLIGSNHSLP FLKFATNEAI QRTEAYEYAQ SLGAETCPLP 
      1810       1820       1830       1840       1850
SFQVFKFIYS CRLAEMGLAT QAFHYCEAIA KSILTQPHLY SPVLISQLVQ 
      1860       1870       1880       1890       1900
MASQLRLFDP QLKEKPEEES LAAPTWLVHL QQVERQIKEG AGVWHQDGAL 
      1910       1920       1930       1940       1950
PQQCPGTPSS EMEQLDRPGL SQPGALGIAN PLLAVPAPSP EHSSPSVRLL 
      1960       1970       1980       1990       2000
PSAPQTLPDG PLASPARVPM FPVPLPPGPL EPGPGCVTPG PALGFLEPSG 
      2010       2020       2030       2040       2050
PGLPPGVPPL QERRHLLQEA RSPDPGIVPQ EAPVGNSLSE LSEENFDGKF 
      2060       2070       2080       2090       2100
ANLTPSRTVP DSEAPPGWDR ADSGPTQPPL SLSPAPETKR PGQAAKKETK 
      2110       2120       2130       2140       2150
EPKKGESWFF RWLPGKKKTE AYLPDDKNKS IVWDEKKNQW VNLNEPEEEK 
      2160       2170       2180       2190       2200
KAPPPPPTSM PKTVQAAPPA LPGPPGAPVN MYSRRAAGTR ARYVDVLNPS 
      2210       2220       2230       2240       2250
GTQRSEPALA PADFVAPLAP LPIPSNLFVP TPDAEEPQLP DGTGREGPAA 
      2260       2270       2280       2290       2300
ARGLANPEPA PEPKVLSSAA SLPGSELPSS RPEGSQGGEL SRCSSMSSLS 
      2310       2320       2330       2340       2350
REVSQHFNQA PGDLPAAGGP PSGAMPFYNP AQLAQACATS GSSRLGRIGQ 

RKHLVLN
Length:2,357
Mass (Da):251,894
Last modified:November 7, 2018 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEAE9570BD5CD434B
GO
Isoform 2 (identifier: O15027-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2265-2309: Missing.

Show »
Length:2,312
Mass (Da):247,247
Checksum:i21A238D7B48C0C85
GO
Isoform 3 (identifier: O15027-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2290-2309: Missing.

Show »
Length:2,337
Mass (Da):249,628
Checksum:iDFDABDD30C5D717D
GO
Isoform 4 (identifier: O15027-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2265-2289: Missing.

Show »
Length:2,332
Mass (Da):249,512
Checksum:i321487A041AC7D9F
GO
Isoform 5 (identifier: O15027-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2231-2231: T → TPVSSVRPQGRSGRNDGLLALSS

Show »
Length:2,379
Mass (Da):254,129
Checksum:i89093DD547B2FAA6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1T0I1F1T0I1_HUMAN
Protein transport protein sec16
SEC16A
2,334Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6RGP5X6RGP5_HUMAN
Protein transport protein sec16
SEC16A
1,059Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3F2YNX0A0A3F2YNX0_HUMAN
Protein transport protein sec16
SEC16A
2,134Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3F2YNZ0A0A3F2YNZ0_HUMAN
Protein transport protein sec16
SEC16A
2,154Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DH09A0A0C4DH09_HUMAN
Protein transport protein Sec16A
SEC16A
751Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8N9G1Q8N9G1_HUMAN
Protein transport protein Sec16A
SEC16A
385Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA20769 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1277Y → A in AAH28183 (PubMed:15489334).Curated1
Sequence conflicti2279S → P in AAH28183 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0233321039R → C. Corresponds to variant dbSNP:rs3812594Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0360292231T → TPVSSVRPQGRSGRNDGLLA LSS in isoform 5. 1 Publication1
Alternative sequenceiVSP_0152522265 – 2309Missing in isoform 2. CuratedAdd BLAST45
Alternative sequenceiVSP_0343702265 – 2289Missing in isoform 4. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_0152532290 – 2309Missing in isoform 3. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB002308 mRNA Translation: BAA20769.4 Different initiation.
AL592301 Genomic DNA No translation available.
DQ903855 mRNA Translation: ABI78944.1
BC008332 mRNA Translation: AAH08332.1
BC028183 mRNA Translation: AAH28183.1
BC098454 mRNA Translation: AAH98454.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS55351.1 [O15027-1]

NCBI Reference Sequences

More...RefSeqi		NP_001263347.1, NM_001276418.1
NP_055681.1, NM_014866.1 [O15027-1]
XP_005266191.1, XM_005266134.2 [O15027-5]
XP_011517548.1, XM_011519246.2 [O15027-5]
XP_011517549.1, XM_011519247.1 [O15027-5]
XP_011517550.1, XM_011519248.2 [O15027-5]
XP_011517554.1, XM_011519252.2 [O15027-1]
XP_011517557.1, XM_011519255.2 [O15027-3]
XP_011517559.1, XM_011519257.1 [O15027-4]
XP_011517561.1, XM_011519259.1 [O15027-2]
XP_011517562.1, XM_011519260.2 [O15027-5]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000313050; ENSP00000325827; ENSG00000148396 [O15027-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9919

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9919

UCSC genome browser

More...UCSCi		uc064xch.1 human [O15027-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002308 mRNA Translation: BAA20769.4 Different initiation.
AL592301 Genomic DNA No translation available.
DQ903855 mRNA Translation: ABI78944.1
BC008332 mRNA Translation: AAH08332.1
BC028183 mRNA Translation: AAH28183.1
BC098454 mRNA Translation: AAH98454.1
CCDSiCCDS55351.1 [O15027-1]
RefSeqiNP_001263347.1, NM_001276418.1
NP_055681.1, NM_014866.1 [O15027-1]
XP_005266191.1, XM_005266134.2 [O15027-5]
XP_011517548.1, XM_011519246.2 [O15027-5]
XP_011517549.1, XM_011519247.1 [O15027-5]
XP_011517550.1, XM_011519248.2 [O15027-5]
XP_011517554.1, XM_011519252.2 [O15027-1]
XP_011517557.1, XM_011519255.2 [O15027-3]
XP_011517559.1, XM_011519257.1 [O15027-4]
XP_011517561.1, XM_011519259.1 [O15027-2]
XP_011517562.1, XM_011519260.2 [O15027-5]

3D structure databases

SMRiO15027
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115247, 229 interactors
CORUMiO15027
DIPiDIP-27588N
IntActiO15027, 195 interactors
MINTiO15027
STRINGi9606.ENSP00000325827

PTM databases

iPTMnetiO15027
PhosphoSitePlusiO15027

Polymorphism and mutation databases

BioMutaiSEC16A

Proteomic databases

EPDiO15027
jPOSTiO15027
MassIVEiO15027
MaxQBiO15027
PaxDbiO15027
PeptideAtlasiO15027
PRIDEiO15027
ProteomicsDBi48383 [O15027-1]
48384 [O15027-2]
48385 [O15027-3]
48386 [O15027-4]
48387 [O15027-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1693 45 antibodies

Genome annotation databases

EnsembliENST00000313050; ENSP00000325827; ENSG00000148396 [O15027-1]
GeneIDi9919
KEGGihsa:9919
UCSCiuc064xch.1 human [O15027-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9919
DisGeNETi9919

GeneCards: human genes, protein and diseases

More...GeneCardsi		SEC16A
HGNCiHGNC:29006 SEC16A
HPAiENSG00000148396 Low tissue specificity
MIMi612854 gene
neXtProtiNX_O15027
OpenTargetsiENSG00000148396
PharmGKBiPA162402611

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1913 Eukaryota
ENOG4111J6D LUCA
GeneTreeiENSGT00940000159324
HOGENOMiCLU_001465_0_0_1
InParanoidiO15027
KOiK20353
OMAiAAHICFI
OrthoDBi235062at2759
PhylomeDBiO15027
TreeFamiTF316276

Enzyme and pathway databases

ReactomeiR-HSA-204005 COPII-mediated vesicle transport
SIGNORiO15027

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SEC16A human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SEC16A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9919
PharosiO15027 Tbio

Protein Ontology

More...PROi		PR:O15027
RNActiO15027 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000148396 Expressed in adenohypophysis and 228 other tissues
ExpressionAtlasiO15027 baseline and differential
GenevisibleiO15027 HS

Family and domain databases

CDDicd09233 ACE1-Sec16-like, 1 hit
InterProiView protein in InterPro
IPR024298 ACE1_Sec16_Sec31
IPR024880 Sec16
IPR024340 Sec16_CCD
PfamiView protein in Pfam
PF12932 Sec16, 1 hit
PF12931 Sec16_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSC16A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15027
Secondary accession number(s): A1YCA4
, J3KNL6, Q4G0D7, Q5SXP0, Q5SXP1, Q8N347, Q96HP1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 7, 2018
Last modified: April 22, 2020
This is version 174 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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