UniProtKB - O15027 (SC16A_HUMAN)
Protein transport protein Sec16A
SEC16A
Functioni
GO - Biological processi
- autophagy Source: InterPro
- COPII vesicle coating Source: GO_Central
- endoplasmic reticulum organization Source: UniProtKB
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: UniProtKB
- Golgi organization Source: GO_Central
- Golgi to plasma membrane CFTR protein transport Source: UniProtKB
- positive regulation of protein exit from endoplasmic reticulum Source: GO_Central
- protein exit from endoplasmic reticulum Source: UniProtKB
- protein localization to endoplasmic reticulum exit site Source: UniProtKB
- protein localization to plasma membrane Source: UniProtKB
- protein stabilization Source: UniProtKB
- response to endoplasmic reticulum stress Source: UniProtKB
- substantia nigra development Source: UniProtKB
Keywordsi
Biological process | ER-Golgi transport, Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | O15027 |
Reactomei | R-HSA-204005, COPII-mediated vesicle transport |
SIGNORi | O15027 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein transport protein Sec16AAlternative name(s): SEC16 homolog A Short name: p2501 Publication |
Gene namesi | Name:SEC16A Synonyms:KIAA0310, SEC16, SEC16L |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000148396.18 |
HGNCi | HGNC:29006, SEC16A |
MIMi | 612854, gene |
neXtProti | NX_O15027 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane Curated; Peripheral membrane protein Curated
Cytosol
- cytosol 2 Publications
Endoplasmic reticulum
- Endoplasmic reticulum membrane 2 Publications; Peripheral membrane protein 1 Publication
- Microsome membrane 1 Publication
Other locations
- perinuclear region By similarity
Note: SAR1A activity is required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation (PubMed:17192411). Localizes to endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). MIA3 and LRRK2 are required for its proper localization to ERES (PubMed:25201882, PubMed:28442536, PubMed:19638414, PubMed:17428803, PubMed:22355596). Recruited to microsomal membrane in SAR1-dependent manner (PubMed:17428803).6 Publications
Cytosol
- cytosol Source: UniProtKB
Endoplasmic reticulum
- endoplasmic reticulum Source: HPA
- endoplasmic reticulum exit site Source: UniProtKB
- endoplasmic reticulum membrane Source: UniProtKB
Golgi apparatus
- Golgi apparatus Source: HPA
- Golgi membrane Source: UniProtKB-SubCell
Other locations
- ER to Golgi transport vesicle membrane Source: GO_Central
- organelle membrane Source: UniProtKB
- perinuclear region of cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Membrane, MicrosomePathology & Biotechi
Organism-specific databases
DisGeNETi | 9919 |
OpenTargetsi | ENSG00000148396 |
PharmGKBi | PA162402611 |
Miscellaneous databases
Pharosi | O15027, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4295654 |
Polymorphism and mutation databases
BioMutai | SEC16A |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000050746 | 1 – 2357 | Protein transport protein Sec16AAdd BLAST | 2357 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 296 | PhosphoserineCombined sources | 1 | |
Modified residuei | 314 | PhosphoserineCombined sources | 1 | |
Modified residuei | 331 | PhosphoserineCombined sources | 1 | |
Modified residuei | 559 | PhosphoserineCombined sources | 1 | |
Modified residuei | 569 | PhosphoserineCombined sources | 1 | |
Modified residuei | 587 | PhosphoserineCombined sources | 1 | |
Modified residuei | 589 | PhosphoserineCombined sources | 1 | |
Modified residuei | 592 | PhosphoserineCombined sources | 1 | |
Modified residuei | 593 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 595 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1069 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1207 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1229 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1305 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1325 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1327 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1347 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1350 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1356 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1359 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1362 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1369 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1573 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1601 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1907 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1939 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1964 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2022 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2042 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2054 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 2056 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2073 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2083 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2271 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2291 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | O15027 |
jPOSTi | O15027 |
MassIVEi | O15027 |
MaxQBi | O15027 |
PaxDbi | O15027 |
PeptideAtlasi | O15027 |
PRIDEi | O15027 |
ProteomicsDBi | 48383 [O15027-1] 48384 [O15027-2] 48385 [O15027-3] 48386 [O15027-4] 48387 [O15027-5] |
PTM databases
iPTMneti | O15027 |
PhosphoSitePlusi | O15027 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000148396, Expressed in adenohypophysis and 241 other tissues |
ExpressionAtlasi | O15027, baseline and differential |
Genevisiblei | O15027, HS |
Organism-specific databases
HPAi | ENSG00000148396, Low tissue specificity |
Interactioni
Subunit structurei
SEC16A and SEC16B are each present in multiple copies in a heteromeric complex (PubMed:17192411, PubMed:22355596).
Interacts with SEC23A (PubMed:17192411, PubMed:17428803).
Interacts with RNF183 and RNF152 (PubMed:29300766).
Interacts with LRRK2 (via ROC domain) (PubMed:25201882).
Interacts with SEC13 (PubMed:25201882, PubMed:19638414, PubMed:17428803).
Interacts with RAB10 (By similarity).
Interacts with MIA3 (PubMed:28442536).
Interacts with GORASP2 in response to ER stress (PubMed:28067262).
By similarity8 PublicationsBinary interactionsi
Hide detailsO15027
With | #Exp. | IntAct |
---|---|---|
DOCK7 [Q96N67] | 3 | EBI-357515,EBI-2433703 |
LRRK2 [Q5S007] | 8 | EBI-357515,EBI-5323863 |
NBEAL2 [Q6ZNJ1] | 6 | EBI-357515,EBI-2862306 |
Protein-protein interaction databases
BioGRIDi | 115247, 243 interactors |
CORUMi | O15027 |
DIPi | DIP-27588N |
IntActi | O15027, 199 interactors |
MINTi | O15027 |
STRINGi | 9606.ENSP00000325827 |
Miscellaneous databases
RNActi | O15027, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1019 – 1890 | Required for localization to endoplasmic reticulum exit sites1 PublicationAdd BLAST | 872 | |
Regioni | 1101 – 1400 | Interaction with MIA31 PublicationAdd BLAST | 300 | |
Regioni | 1102 – 1405 | Required for endoplasmic reticulum localization1 PublicationAdd BLAST | 304 | |
Regioni | 1434 – 1890 | Central conserved domain (CCD); mediates interaction with RNF183, LRRK2 and SEC133 PublicationsAdd BLAST | 457 | |
Regioni | 2106 – 2357 | Required for interaction with SEC23A1 PublicationAdd BLAST | 252 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1113 – 1181 | Pro-richAdd BLAST | 69 | |
Compositional biasi | 1159 – 1162 | Poly-Tyr | 4 | |
Compositional biasi | 1591 – 1594 | Poly-Glu | 4 | |
Compositional biasi | 1931 – 2285 | Pro-richAdd BLAST | 355 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1913, Eukaryota |
GeneTreei | ENSGT00940000159324 |
HOGENOMi | CLU_001465_0_0_1 |
InParanoidi | O15027 |
OMAi | AAHICFI |
OrthoDBi | 235062at2759 |
PhylomeDBi | O15027 |
TreeFami | TF316276 |
Family and domain databases
InterProi | View protein in InterPro IPR024298, ACE1_Sec16_Sec31 IPR024880, Sec16 IPR024340, Sec16_CCD |
PANTHERi | PTHR13402, PTHR13402, 1 hit |
Pfami | View protein in Pfam PF12932, Sec16, 1 hit PF12931, Sec16_C, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MQPPPQTVPS GMAGPPPAGN PRSVFWASSP YRRRANNNAA VAPTTCPLQP
60 70 80 90 100
VTDPFAFSRQ ALQSTPLGSS SKSSPPVLQG PAPAGFSQHP GLLVPHTHAR
110 120 130 140 150
DSSQGPCEPL PGPLTQPRAH ASPFSGALTP SAPPGPEMNR SAEVGPSSEP
160 170 180 190 200
EVQTLPYLPH YIPGVDPETS HGGHPHGNMP GLDRPLSRQN PHDGVVTPAA
210 220 230 240 250
SPSLPQPGLQ MPGQWGPVQG GPQPSGQHRS PCPEGPVPSG VPCATSVPHF
260 270 280 290 300
PTPSILHQGP GHEQHSPLVA PPAALPSDGR DEVSHLQSGS HLANNSDPES
310 320 330 340 350
TFRQNPRIVN HWASPELRQN PGVKNEHRPA SALVNPLARG DSPENRTHHP
360 370 380 390 400
LGAGAGSGCA PLEADSGASG ALAMFFQGGE TENEENLSSE KAGLSGQADF
410 420 430 440 450
DDFCSSPGLG RPPAPTHVGA GSLCQALLPG PSNEAAGDVW GDTASTGVPD
460 470 480 490 500
ASGSQYENVE NLEFVQNQEV LPSEPLNLDP SSPSDQFRYG PLPGPAVPRH
510 520 530 540 550
GAVCHTGAPD ATLHTVHPDS VSSSYSSRSH GRLSGSARPQ ELVGTFIQQE
560 570 580 590 600
VGKPEDEASG SFFKQIDSSP VGGETDETTV SQNYRGSVSQ PSTPSPPKPT
610 620 630 640 650
GIFQTSANSS FEPVKSHLVG VKPFEADRAN VVGEVRETCV RQKQCRPAAA
660 670 680 690 700
LPDASPGNLE QPPDNMETLC APQVCPLPLN STTEAVHMLP HAGAPPLDTV
710 720 730 740 750
YPAPEKRPSA RTQGPVKCES PATTLWAQSE LPDFGGNVLL APAAPALYVC
760 770 780 790 800
AKPQPPVVQP PEEAMSGQQS RNPSSAAPVQ SRGGIGASEN LENPPKMGEE
810 820 830 840 850
EALQSQASSG YASLLSSPPT ESLQNPPVLI AQPDHSYNLA QPINFSVSLS
860 870 880 890 900
NSHEKNQSWR EALVGDRPAV SSWALGGDSG ENTSLSGIPT SSVLSLSLPS
910 920 930 940 950
SVAQSNFPQG SGASEMVSNQ PANLLVQPPS QPVPENLVPE SQKDRKAGSA
960 970 980 990 1000
LPGFANSPAG STSVVLVPPA HGTLVPDGNK ANHSSHQEDT YGALDFTLSR
1010 1020 1030 1040 1050
TLENPVNVYN PSHSDSLASQ QSVASHPRQS GPGAPNLDRF YQQVTKDAQG
1060 1070 1080 1090 1100
QPGLERAQQE LVPPQQQASP PQLPKAMFSE LSNPESLPAQ GQAQNSAQSP
1110 1120 1130 1140 1150
ASLVLVDAGQ QLPPRPPQSS SVSLVSSGSG QAAVPSEQPW PQPVPALAPG
1160 1170 1180 1190 1200
PPPQDLAAYY YYRPLYDAYQ PQYSLPYPPE PGAASLYYQD VYSLYEPRYR
1210 1220 1230 1240 1250
PYDGAASAYA QNYRYPEPER PSSRASHSSE RPPPRQGYPE GYYSSKSGWS
1260 1270 1280 1290 1300
SQSDYYASYY SSQYDYGDPG HWDRYHYSAR VRDPRTYDRR YWCDAEYDAY
1310 1320 1330 1340 1350
RREHSAFGDR PEKRDNNWRY DPRFTGSFDD DPDPHRDPYG EEVDRRSVHS
1360 1370 1380 1390 1400
EHSARSLHSA HSLASRRSSL SSHSHQSQIY RSHNVAAGSY EAPLPPGSFH
1410 1420 1430 1440 1450
GDFAYGTYRS NFSSGPGFPE YGYPADTVWP AMEQVSSRPT SPEKFSVPHV
1460 1470 1480 1490 1500
CARFGPGGQL IKVIPNLPSE GQPALVEVHS MEALLQHTSE QEEMRAFPGP
1510 1520 1530 1540 1550
LAKDDTHKVD VINFAQNKAM KCLQNENLID KESASLLWNF IVLLCRQNGT
1560 1570 1580 1590 1600
VVGTDIAELL LRDHRTVWLP GKSPNEANLI DFTNEAVEQV EEEESGEAQL
1610 1620 1630 1640 1650
SFLTGGPAAA ASSLERETER FRELLLYGRK KDALESAMKN GLWGHALLLA
1660 1670 1680 1690 1700
SKMDSRTHAR VMTRFANSLP INDPLQTVYQ LMSGRMPAAS TCCGDEKWGD
1710 1720 1730 1740 1750
WRPHLAMVLS NLNNNMDVES RTMATMGDTL ASRGLLDAAH FCYLMAQAGF
1760 1770 1780 1790 1800
GVYTKKTTKL VLIGSNHSLP FLKFATNEAI QRTEAYEYAQ SLGAETCPLP
1810 1820 1830 1840 1850
SFQVFKFIYS CRLAEMGLAT QAFHYCEAIA KSILTQPHLY SPVLISQLVQ
1860 1870 1880 1890 1900
MASQLRLFDP QLKEKPEEES LAAPTWLVHL QQVERQIKEG AGVWHQDGAL
1910 1920 1930 1940 1950
PQQCPGTPSS EMEQLDRPGL SQPGALGIAN PLLAVPAPSP EHSSPSVRLL
1960 1970 1980 1990 2000
PSAPQTLPDG PLASPARVPM FPVPLPPGPL EPGPGCVTPG PALGFLEPSG
2010 2020 2030 2040 2050
PGLPPGVPPL QERRHLLQEA RSPDPGIVPQ EAPVGNSLSE LSEENFDGKF
2060 2070 2080 2090 2100
ANLTPSRTVP DSEAPPGWDR ADSGPTQPPL SLSPAPETKR PGQAAKKETK
2110 2120 2130 2140 2150
EPKKGESWFF RWLPGKKKTE AYLPDDKNKS IVWDEKKNQW VNLNEPEEEK
2160 2170 2180 2190 2200
KAPPPPPTSM PKTVQAAPPA LPGPPGAPVN MYSRRAAGTR ARYVDVLNPS
2210 2220 2230 2240 2250
GTQRSEPALA PADFVAPLAP LPIPSNLFVP TPDAEEPQLP DGTGREGPAA
2260 2270 2280 2290 2300
ARGLANPEPA PEPKVLSSAA SLPGSELPSS RPEGSQGGEL SRCSSMSSLS
2310 2320 2330 2340 2350
REVSQHFNQA PGDLPAAGGP PSGAMPFYNP AQLAQACATS GSSRLGRIGQ
RKHLVLN
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF1T0I1 | F1T0I1_HUMAN | Protein transport protein sec16 | SEC16A | 2,334 | Annotation score: | ||
X6RGP5 | X6RGP5_HUMAN | Protein transport protein sec16 | SEC16A | 1,059 | Annotation score: | ||
A0A3F2YNX0 | A0A3F2YNX0_HUMAN | Protein transport protein sec16 | SEC16A | 2,134 | Annotation score: | ||
A0A3F2YNZ0 | A0A3F2YNZ0_HUMAN | Protein transport protein sec16 | SEC16A | 2,154 | Annotation score: | ||
A0A0C4DH09 | A0A0C4DH09_HUMAN | Protein transport protein Sec16A | SEC16A | 751 | Annotation score: | ||
Q8N9G1 | Q8N9G1_HUMAN | Protein transport protein Sec16A | SEC16A | 385 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1277 | Y → A in AAH28183 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 2279 | S → P in AAH28183 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_023332 | 1039 | R → C. Corresponds to variant dbSNP:rs3812594Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_036029 | 2231 | T → TPVSSVRPQGRSGRNDGLLA LSS in isoform 5. 1 Publication | 1 | |
Alternative sequenceiVSP_015252 | 2265 – 2309 | Missing in isoform 2. CuratedAdd BLAST | 45 | |
Alternative sequenceiVSP_034370 | 2265 – 2289 | Missing in isoform 4. 1 PublicationAdd BLAST | 25 | |
Alternative sequenceiVSP_015253 | 2290 – 2309 | Missing in isoform 3. 1 PublicationAdd BLAST | 20 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB002308 mRNA Translation: BAA20769.4 Different initiation. AL592301 Genomic DNA No translation available. DQ903855 mRNA Translation: ABI78944.1 BC008332 mRNA Translation: AAH08332.1 BC028183 mRNA Translation: AAH28183.1 BC098454 mRNA Translation: AAH98454.1 |
CCDSi | CCDS55351.1 [O15027-1] |
RefSeqi | NP_001263347.1, NM_001276418.1 NP_055681.1, NM_014866.1 [O15027-1] XP_005266191.1, XM_005266134.2 [O15027-5] XP_011517548.1, XM_011519246.2 [O15027-5] XP_011517549.1, XM_011519247.1 [O15027-5] XP_011517550.1, XM_011519248.2 [O15027-5] XP_011517554.1, XM_011519252.2 [O15027-1] XP_011517557.1, XM_011519255.2 [O15027-3] XP_011517559.1, XM_011519257.1 [O15027-4] XP_011517561.1, XM_011519259.1 [O15027-2] XP_011517562.1, XM_011519260.2 [O15027-5] |
Genome annotation databases
Ensembli | ENST00000313050; ENSP00000325827; ENSG00000148396 [O15027-1] |
GeneIDi | 9919 |
KEGGi | hsa:9919 |
UCSCi | uc064xch.1, human [O15027-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB002308 mRNA Translation: BAA20769.4 Different initiation. AL592301 Genomic DNA No translation available. DQ903855 mRNA Translation: ABI78944.1 BC008332 mRNA Translation: AAH08332.1 BC028183 mRNA Translation: AAH28183.1 BC098454 mRNA Translation: AAH98454.1 |
CCDSi | CCDS55351.1 [O15027-1] |
RefSeqi | NP_001263347.1, NM_001276418.1 NP_055681.1, NM_014866.1 [O15027-1] XP_005266191.1, XM_005266134.2 [O15027-5] XP_011517548.1, XM_011519246.2 [O15027-5] XP_011517549.1, XM_011519247.1 [O15027-5] XP_011517550.1, XM_011519248.2 [O15027-5] XP_011517554.1, XM_011519252.2 [O15027-1] XP_011517557.1, XM_011519255.2 [O15027-3] XP_011517559.1, XM_011519257.1 [O15027-4] XP_011517561.1, XM_011519259.1 [O15027-2] XP_011517562.1, XM_011519260.2 [O15027-5] |
3D structure databases
SMRi | O15027 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 115247, 243 interactors |
CORUMi | O15027 |
DIPi | DIP-27588N |
IntActi | O15027, 199 interactors |
MINTi | O15027 |
STRINGi | 9606.ENSP00000325827 |
Chemistry databases
ChEMBLi | CHEMBL4295654 |
PTM databases
iPTMneti | O15027 |
PhosphoSitePlusi | O15027 |
Polymorphism and mutation databases
BioMutai | SEC16A |
Proteomic databases
EPDi | O15027 |
jPOSTi | O15027 |
MassIVEi | O15027 |
MaxQBi | O15027 |
PaxDbi | O15027 |
PeptideAtlasi | O15027 |
PRIDEi | O15027 |
ProteomicsDBi | 48383 [O15027-1] 48384 [O15027-2] 48385 [O15027-3] 48386 [O15027-4] 48387 [O15027-5] |
Protocols and materials databases
Antibodypediai | 1693, 46 antibodies |
Genome annotation databases
Ensembli | ENST00000313050; ENSP00000325827; ENSG00000148396 [O15027-1] |
GeneIDi | 9919 |
KEGGi | hsa:9919 |
UCSCi | uc064xch.1, human [O15027-1] |
Organism-specific databases
CTDi | 9919 |
DisGeNETi | 9919 |
EuPathDBi | HostDB:ENSG00000148396.18 |
GeneCardsi | SEC16A |
HGNCi | HGNC:29006, SEC16A |
HPAi | ENSG00000148396, Low tissue specificity |
MIMi | 612854, gene |
neXtProti | NX_O15027 |
OpenTargetsi | ENSG00000148396 |
PharmGKBi | PA162402611 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1913, Eukaryota |
GeneTreei | ENSGT00940000159324 |
HOGENOMi | CLU_001465_0_0_1 |
InParanoidi | O15027 |
OMAi | AAHICFI |
OrthoDBi | 235062at2759 |
PhylomeDBi | O15027 |
TreeFami | TF316276 |
Enzyme and pathway databases
PathwayCommonsi | O15027 |
Reactomei | R-HSA-204005, COPII-mediated vesicle transport |
SIGNORi | O15027 |
Miscellaneous databases
BioGRID-ORCSi | 9919, 397 hits in 842 CRISPR screens |
ChiTaRSi | SEC16A, human |
GeneWikii | SEC16A |
GenomeRNAii | 9919 |
Pharosi | O15027, Tbio |
PROi | PR:O15027 |
RNActi | O15027, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000148396, Expressed in adenohypophysis and 241 other tissues |
ExpressionAtlasi | O15027, baseline and differential |
Genevisiblei | O15027, HS |
Family and domain databases
InterProi | View protein in InterPro IPR024298, ACE1_Sec16_Sec31 IPR024880, Sec16 IPR024340, Sec16_CCD |
PANTHERi | PTHR13402, PTHR13402, 1 hit |
Pfami | View protein in Pfam PF12932, Sec16, 1 hit PF12931, Sec16_C, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SC16A_HUMAN | |
Accessioni | O15027Primary (citable) accession number: O15027 Secondary accession number(s): A1YCA4 Q96HP1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | November 7, 2018 | |
Last modified: | December 2, 2020 | |
This is version 178 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations