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Protein

Protein transport protein Sec16A

Gene

SEC16A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17192411, PubMed:17005010, PubMed:17428803). Mediates the recruitment of MIA3/TANGO to ERES (PubMed:28442536). Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane (PubMed:28067262). Positively regulates the protein stability of E3 ubiquitin-protein ligases RNF152 and RNF183 and the ER localization of RNF183 (PubMed:29300766). Acts as a RAB10 effector in the regulation of insulin-induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the cell membrane in adipocytes (By similarity).By similarity6 Publications

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-204005 COPII-mediated vesicle transport
SIGNORiO15027

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein Sec16A
Alternative name(s):
SEC16 homolog A
Short name:
p2501 Publication
Gene namesi
Name:SEC16A
Synonyms:KIAA0310, SEC16, SEC16L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000148396.18
HGNCiHGNC:29006 SEC16A
MIMi612854 gene
neXtProtiNX_O15027

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi9919
OpenTargetsiENSG00000148396
PharmGKBiPA162402611

Polymorphism and mutation databases

BioMutaiSEC16A

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000507461 – 2357Protein transport protein Sec16AAdd BLAST2357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei296PhosphoserineCombined sources1
Modified residuei314PhosphoserineCombined sources1
Modified residuei331PhosphoserineCombined sources1
Modified residuei559PhosphoserineCombined sources1
Modified residuei569PhosphoserineCombined sources1
Modified residuei587PhosphoserineCombined sources1
Modified residuei589PhosphoserineCombined sources1
Modified residuei592PhosphoserineCombined sources1
Modified residuei593PhosphothreonineCombined sources1
Modified residuei595PhosphoserineCombined sources1
Modified residuei1069PhosphoserineCombined sources1
Modified residuei1207PhosphoserineCombined sources1
Modified residuei1229PhosphoserineCombined sources1
Modified residuei1305PhosphoserineCombined sources1
Modified residuei1325PhosphothreonineCombined sources1
Modified residuei1327PhosphoserineCombined sources1
Modified residuei1347PhosphoserineCombined sources1
Modified residuei1350PhosphoserineCombined sources1
Modified residuei1356PhosphoserineCombined sources1
Modified residuei1359PhosphoserineCombined sources1
Modified residuei1362PhosphoserineCombined sources1
Modified residuei1369PhosphoserineCombined sources1
Modified residuei1573PhosphoserineCombined sources1
Modified residuei1601PhosphoserineCombined sources1
Modified residuei1907PhosphothreonineCombined sources1
Modified residuei1939PhosphoserineCombined sources1
Modified residuei1964PhosphoserineCombined sources1
Modified residuei2022PhosphoserineCombined sources1
Modified residuei2042PhosphoserineCombined sources1
Modified residuei2054PhosphothreonineCombined sources1
Modified residuei2056PhosphoserineCombined sources1
Modified residuei2073PhosphoserineCombined sources1
Modified residuei2083PhosphoserineCombined sources1
Modified residuei2271PhosphoserineCombined sources1
Modified residuei2291PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO15027
MaxQBiO15027
PaxDbiO15027
PeptideAtlasiO15027
PRIDEiO15027
ProteomicsDBi48383
48384 [O15027-2]
48385 [O15027-3]
48386 [O15027-4]
48387 [O15027-5]

PTM databases

iPTMnetiO15027
PhosphoSitePlusiO15027

Expressioni

Tissue specificityi

Ubiquitous. Expressed at higher levels in the pancreas.1 Publication

Gene expression databases

BgeeiENSG00000148396 Expressed in 229 organ(s), highest expression level in adenohypophysis
CleanExiHS_SEC16A
ExpressionAtlasiO15027 baseline and differential
GenevisibleiO15027 HS

Organism-specific databases

HPAiHPA005684

Interactioni

Subunit structurei

SEC16A and SEC16B are each present in multiple copies in a heteromeric complex (PubMed:17192411). Interacts with SEC23A (PubMed:17192411, PubMed:17428803). Interacts with RNF183 and RNF152 (PubMed:29300766). Interacts with LRRK2 (via ROC domain) (PubMed:25201882). Interacts with SEC13 (PubMed:25201882, PubMed:19638414, PubMed:17428803). Interacts with RAB10 (By similarity). Interacts with MIA3 (PubMed:28442536). Interacts with GORASP2 in response to ER stress (PubMed:28067262).By similarity7 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi115247, 181 interactors
CORUMiO15027
DIPiDIP-27588N
IntActiO15027, 163 interactors
MINTiO15027
STRINGi9606.ENSP00000325827

Structurei

3D structure databases

ProteinModelPortaliO15027
SMRiO15027
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1019 – 1890Required for localization to endoplasmic reticulum exit sites1 PublicationAdd BLAST872
Regioni1101 – 1400Interaction with MIA31 PublicationAdd BLAST300
Regioni1102 – 1405Required for endoplasmic reticulum localization1 PublicationAdd BLAST304
Regioni1434 – 1890Central conserved domain (CCD); mediates interaction with RNF183, LRRK2 and SEC133 PublicationsAdd BLAST457
Regioni2106 – 2357Required for interaction with SEC23A1 PublicationAdd BLAST252

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1113 – 1181Pro-richAdd BLAST69
Compositional biasi1159 – 1162Poly-Tyr4
Compositional biasi1591 – 1594Poly-Glu4
Compositional biasi1931 – 2285Pro-richAdd BLAST355

Sequence similaritiesi

Belongs to the SEC16 family.Curated

Phylogenomic databases

eggNOGiKOG1913 Eukaryota
ENOG4111J6D LUCA
GeneTreeiENSGT00530000063746
HOVERGENiHBG079941
InParanoidiO15027
KOiK20353
OMAiLKKWVNK
OrthoDBiEOG091G00RM
PhylomeDBiO15027
TreeFamiTF316276

Family and domain databases

CDDicd09233 ACE1-Sec16-like, 1 hit
InterProiView protein in InterPro
IPR024298 ACE1_Sec16_Sec31
IPR024880 Sec16
IPR024340 Sec16_CCD
PfamiView protein in Pfam
PF12932 Sec16, 1 hit
PF12931 Sec16_C, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O15027-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQPPPQTVPS GMAGPPPAGN PRSVFWASSP YRRRANNNAA VAPTTCPLQP
60 70 80 90 100
VTDPFAFSRQ ALQSTPLGSS SKSSPPVLQG PAPAGFSQHP GLLVPHTHAR
110 120 130 140 150
DSSQGPCEPL PGPLTQPRAH ASPFSGALTP SAPPGPEMNR SAEVGPSSEP
160 170 180 190 200
EVQTLPYLPH YIPGVDPETS HGGHPHGNMP GLDRPLSRQN PHDGVVTPAA
210 220 230 240 250
SPSLPQPGLQ MPGQWGPVQG GPQPSGQHRS PCPEGPVPSG VPCATSVPHF
260 270 280 290 300
PTPSILHQGP GHEQHSPLVA PPAALPSDGR DEVSHLQSGS HLANNSDPES
310 320 330 340 350
TFRQNPRIVN HWASPELRQN PGVKNEHRPA SALVNPLARG DSPENRTHHP
360 370 380 390 400
LGAGAGSGCA PLEADSGASG ALAMFFQGGE TENEENLSSE KAGLSGQADF
410 420 430 440 450
DDFCSSPGLG RPPAPTHVGA GSLCQALLPG PSNEAAGDVW GDTASTGVPD
460 470 480 490 500
ASGSQYENVE NLEFVQNQEV LPSEPLNLDP SSPSDQFRYG PLPGPAVPRH
510 520 530 540 550
GAVCHTGAPD ATLHTVHPDS VSSSYSSRSH GRLSGSARPQ ELVGTFIQQE
560 570 580 590 600
VGKPEDEASG SFFKQIDSSP VGGETDETTV SQNYRGSVSQ PSTPSPPKPT
610 620 630 640 650
GIFQTSANSS FEPVKSHLVG VKPFEADRAN VVGEVRETCV RQKQCRPAAA
660 670 680 690 700
LPDASPGNLE QPPDNMETLC APQVCPLPLN STTEAVHMLP HAGAPPLDTV
710 720 730 740 750
YPAPEKRPSA RTQGPVKCES PATTLWAQSE LPDFGGNVLL APAAPALYVC
760 770 780 790 800
AKPQPPVVQP PEEAMSGQQS RNPSSAAPVQ SRGGIGASEN LENPPKMGEE
810 820 830 840 850
EALQSQASSG YASLLSSPPT ESLQNPPVLI AQPDHSYNLA QPINFSVSLS
860 870 880 890 900
NSHEKNQSWR EALVGDRPAV SSWALGGDSG ENTSLSGIPT SSVLSLSLPS
910 920 930 940 950
SVAQSNFPQG SGASEMVSNQ PANLLVQPPS QPVPENLVPE SQKDRKAGSA
960 970 980 990 1000
LPGFANSPAG STSVVLVPPA HGTLVPDGNK ANHSSHQEDT YGALDFTLSR
1010 1020 1030 1040 1050
TLENPVNVYN PSHSDSLASQ QSVASHPRQS GPGAPNLDRF YQQVTKDAQG
1060 1070 1080 1090 1100
QPGLERAQQE LVPPQQQASP PQLPKAMFSE LSNPESLPAQ GQAQNSAQSP
1110 1120 1130 1140 1150
ASLVLVDAGQ QLPPRPPQSS SVSLVSSGSG QAAVPSEQPW PQPVPALAPG
1160 1170 1180 1190 1200
PPPQDLAAYY YYRPLYDAYQ PQYSLPYPPE PGAASLYYQD VYSLYEPRYR
1210 1220 1230 1240 1250
PYDGAASAYA QNYRYPEPER PSSRASHSSE RPPPRQGYPE GYYSSKSGWS
1260 1270 1280 1290 1300
SQSDYYASYY SSQYDYGDPG HWDRYHYSAR VRDPRTYDRR YWCDAEYDAY
1310 1320 1330 1340 1350
RREHSAFGDR PEKRDNNWRY DPRFTGSFDD DPDPHRDPYG EEVDRRSVHS
1360 1370 1380 1390 1400
EHSARSLHSA HSLASRRSSL SSHSHQSQIY RSHNVAAGSY EAPLPPGSFH
1410 1420 1430 1440 1450
GDFAYGTYRS NFSSGPGFPE YGYPADTVWP AMEQVSSRPT SPEKFSVPHV
1460 1470 1480 1490 1500
CARFGPGGQL IKVIPNLPSE GQPALVEVHS MEALLQHTSE QEEMRAFPGP
1510 1520 1530 1540 1550
LAKDDTHKVD VINFAQNKAM KCLQNENLID KESASLLWNF IVLLCRQNGT
1560 1570 1580 1590 1600
VVGTDIAELL LRDHRTVWLP GKSPNEANLI DFTNEAVEQV EEEESGEAQL
1610 1620 1630 1640 1650
SFLTGGPAAA ASSLERETER FRELLLYGRK KDALESAMKN GLWGHALLLA
1660 1670 1680 1690 1700
SKMDSRTHAR VMTRFANSLP INDPLQTVYQ LMSGRMPAAS TCCGDEKWGD
1710 1720 1730 1740 1750
WRPHLAMVLS NLNNNMDVES RTMATMGDTL ASRGLLDAAH FCYLMAQAGF
1760 1770 1780 1790 1800
GVYTKKTTKL VLIGSNHSLP FLKFATNEAI QRTEAYEYAQ SLGAETCPLP
1810 1820 1830 1840 1850
SFQVFKFIYS CRLAEMGLAT QAFHYCEAIA KSILTQPHLY SPVLISQLVQ
1860 1870 1880 1890 1900
MASQLRLFDP QLKEKPEEES LAAPTWLVHL QQVERQIKEG AGVWHQDGAL
1910 1920 1930 1940 1950
PQQCPGTPSS EMEQLDRPGL SQPGALGIAN PLLAVPAPSP EHSSPSVRLL
1960 1970 1980 1990 2000
PSAPQTLPDG PLASPARVPM FPVPLPPGPL EPGPGCVTPG PALGFLEPSG
2010 2020 2030 2040 2050
PGLPPGVPPL QERRHLLQEA RSPDPGIVPQ EAPVGNSLSE LSEENFDGKF
2060 2070 2080 2090 2100
ANLTPSRTVP DSEAPPGWDR ADSGPTQPPL SLSPAPETKR PGQAAKKETK
2110 2120 2130 2140 2150
EPKKGESWFF RWLPGKKKTE AYLPDDKNKS IVWDEKKNQW VNLNEPEEEK
2160 2170 2180 2190 2200
KAPPPPPTSM PKTVQAAPPA LPGPPGAPVN MYSRRAAGTR ARYVDVLNPS
2210 2220 2230 2240 2250
GTQRSEPALA PADFVAPLAP LPIPSNLFVP TPDAEEPQLP DGTGREGPAA
2260 2270 2280 2290 2300
ARGLANPEPA PEPKVLSSAA SLPGSELPSS RPEGSQGGEL SRCSSMSSLS
2310 2320 2330 2340 2350
REVSQHFNQA PGDLPAAGGP PSGAMPFYNP AQLAQACATS GSSRLGRIGQ

RKHLVLN
Length:2,357
Mass (Da):251,894
Last modified:November 7, 2018 - v4
Checksum:iEAE9570BD5CD434B
GO
Isoform 2 (identifier: O15027-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2265-2309: Missing.

Note: No experimental confirmation available.
Show »
Length:2,312
Mass (Da):247,247
Checksum:i21A238D7B48C0C85
GO
Isoform 3 (identifier: O15027-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2290-2309: Missing.

Note: No experimental confirmation available.
Show »
Length:2,337
Mass (Da):249,628
Checksum:iDFDABDD30C5D717D
GO
Isoform 4 (identifier: O15027-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2265-2289: Missing.

Show »
Length:2,332
Mass (Da):249,512
Checksum:i321487A041AC7D9F
GO
Isoform 5 (identifier: O15027-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2231-2231: T → TPVSSVRPQGRSGRNDGLLALSS

Note: No experimental confirmation available.
Show »
Length:2,379
Mass (Da):254,129
Checksum:i89093DD547B2FAA6
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1T0I1F1T0I1_HUMAN
Protein transport protein sec16
SEC16A
2,334Annotation score:
X6RGP5X6RGP5_HUMAN
Protein transport protein sec16
SEC16A
1,059Annotation score:
A0A0C4DH09A0A0C4DH09_HUMAN
Protein transport protein Sec16A
SEC16A
751Annotation score:
Q8N9G1Q8N9G1_HUMAN
Protein transport protein Sec16A
SEC16A
385Annotation score:

Sequence cautioni

The sequence BAA20769 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1277Y → A in AAH28183 (PubMed:15489334).Curated1
Sequence conflicti2279S → P in AAH28183 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0233321039R → C. Corresponds to variant dbSNP:rs3812594Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0360292231T → TPVSSVRPQGRSGRNDGLLA LSS in isoform 5. 1 Publication1
Alternative sequenceiVSP_0152522265 – 2309Missing in isoform 2. CuratedAdd BLAST45
Alternative sequenceiVSP_0343702265 – 2289Missing in isoform 4. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_0152532290 – 2309Missing in isoform 3. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002308 mRNA Translation: BAA20769.4 Different initiation.
AL592301 Genomic DNA No translation available.
DQ903855 mRNA Translation: ABI78944.1
BC008332 mRNA Translation: AAH08332.1
BC028183 mRNA Translation: AAH28183.1
BC098454 mRNA Translation: AAH98454.1
RefSeqiNP_001263347.1, NM_001276418.1
NP_055681.1, NM_014866.1
XP_011517554.1, XM_011519252.2
UniGeneiHs.522500

Genome annotation databases

EnsembliENST00000371706; ENSP00000360771; ENSG00000148396 [O15027-2]
ENST00000431893; ENSP00000387583; ENSG00000148396 [O15027-4]
GeneIDi9919
KEGGihsa:9919
UCSCiuc064xch.1 human [O15027-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002308 mRNA Translation: BAA20769.4 Different initiation.
AL592301 Genomic DNA No translation available.
DQ903855 mRNA Translation: ABI78944.1
BC008332 mRNA Translation: AAH08332.1
BC028183 mRNA Translation: AAH28183.1
BC098454 mRNA Translation: AAH98454.1
RefSeqiNP_001263347.1, NM_001276418.1
NP_055681.1, NM_014866.1
XP_011517554.1, XM_011519252.2
UniGeneiHs.522500

3D structure databases

ProteinModelPortaliO15027
SMRiO15027
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115247, 181 interactors
CORUMiO15027
DIPiDIP-27588N
IntActiO15027, 163 interactors
MINTiO15027
STRINGi9606.ENSP00000325827

PTM databases

iPTMnetiO15027
PhosphoSitePlusiO15027

Polymorphism and mutation databases

BioMutaiSEC16A

Proteomic databases

EPDiO15027
MaxQBiO15027
PaxDbiO15027
PeptideAtlasiO15027
PRIDEiO15027
ProteomicsDBi48383
48384 [O15027-2]
48385 [O15027-3]
48386 [O15027-4]
48387 [O15027-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371706; ENSP00000360771; ENSG00000148396 [O15027-2]
ENST00000431893; ENSP00000387583; ENSG00000148396 [O15027-4]
GeneIDi9919
KEGGihsa:9919
UCSCiuc064xch.1 human [O15027-1]

Organism-specific databases

CTDi9919
DisGeNETi9919
EuPathDBiHostDB:ENSG00000148396.18
GeneCardsiSEC16A
H-InvDBiHIX0169092
HGNCiHGNC:29006 SEC16A
HPAiHPA005684
MIMi612854 gene
neXtProtiNX_O15027
OpenTargetsiENSG00000148396
PharmGKBiPA162402611
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1913 Eukaryota
ENOG4111J6D LUCA
GeneTreeiENSGT00530000063746
HOVERGENiHBG079941
InParanoidiO15027
KOiK20353
OMAiLKKWVNK
OrthoDBiEOG091G00RM
PhylomeDBiO15027
TreeFamiTF316276

Enzyme and pathway databases

ReactomeiR-HSA-204005 COPII-mediated vesicle transport
SIGNORiO15027

Miscellaneous databases

ChiTaRSiSEC16A human
GeneWikiiSEC16A
GenomeRNAii9919
PROiPR:O15027
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000148396 Expressed in 229 organ(s), highest expression level in adenohypophysis
CleanExiHS_SEC16A
ExpressionAtlasiO15027 baseline and differential
GenevisibleiO15027 HS

Family and domain databases

CDDicd09233 ACE1-Sec16-like, 1 hit
InterProiView protein in InterPro
IPR024298 ACE1_Sec16_Sec31
IPR024880 Sec16
IPR024340 Sec16_CCD
PfamiView protein in Pfam
PF12932 Sec16, 1 hit
PF12931 Sec16_C, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSC16A_HUMAN
AccessioniPrimary (citable) accession number: O15027
Secondary accession number(s): A1YCA4
, J3KNL6, Q4G0D7, Q5SXP0, Q5SXP1, Q8N347, Q96HP1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 7, 2018
Last modified: November 7, 2018
This is version 162 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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