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Protein

PDZ domain-containing protein 2

Gene

PDZD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
PDZ domain-containing protein 2
Alternative name(s):
Activated in prostate cancer protein
PDZ domain-containing protein 3
Cleaved into the following chain:
Gene namesi
Name:PDZD2
Synonyms:AIPC, KIAA0300, PDZK3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000133401.15
HGNCiHGNC:18486 PDZD2
MIMi610697 gene
neXtProtiNX_O15018

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Nucleus, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi23037
OpenTargetsiENSG00000133401
PharmGKBiPA33164

Polymorphism and mutation databases

BioMutaiPDZD2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000582941 – 2839PDZ domain-containing protein 2Add BLAST2839
ChainiPRO_0000302756?2493 – 2839Processed PDZ domain-containing protein 2By similarityAdd BLAST347

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei568PhosphoserineBy similarity1
Modified residuei944PhosphoserineBy similarity1
Modified residuei948PhosphoserineBy similarity1
Modified residuei1850PhosphoserineBy similarity1

Post-translational modificationi

A secreted form is produced by caspase-mediated proteolytic cleavage.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei2492 – 2493Cleavage; by caspasesBy similarity2

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO15018
MaxQBiO15018
PaxDbiO15018
PeptideAtlasiO15018
PRIDEiO15018
ProteomicsDBi48374
48375 [O15018-2]

PTM databases

iPTMnetiO15018
PhosphoSitePlusiO15018

Expressioni

Tissue specificityi

Isoform 2 is expressed (at protein level) in prostate and many prostate tumors.1 Publication

Gene expression databases

BgeeiENSG00000133401 Expressed in 224 organ(s), highest expression level in caudate nucleus
CleanExiHS_PDZD2
ExpressionAtlasiO15018 baseline and differential
GenevisibleiO15018 HS

Organism-specific databases

HPAiCAB020784
HPA036503
HPA036504
HPA064387

Interactioni

Subunit structurei

Interacts with SCN10A, CTNND2 and PKP4.By similarity

Protein-protein interaction databases

BioGridi116676, 12 interactors
IntActiO15018, 3 interactors
STRINGi9606.ENSP00000282493

Structurei

3D structure databases

ProteinModelPortaliO15018
SMRiO15018
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 182PDZ 1PROSITE-ProRule annotationAdd BLAST98
Domaini334 – 419PDZ 2PROSITE-ProRule annotationAdd BLAST86
Domaini586 – 672PDZ 3PROSITE-ProRule annotationAdd BLAST87
Domaini728 – 813PDZ 4PROSITE-ProRule annotationAdd BLAST86
Domaini2622 – 2706PDZ 5PROSITE-ProRule annotationAdd BLAST85
Domaini2750 – 2835PDZ 6PROSITE-ProRule annotationAdd BLAST86

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2139 – 2194Ser-richAdd BLAST56

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0708 Eukaryota
KOG3528 Eukaryota
ENOG4110362 LUCA
GeneTreeiENSGT00760000119017
HOGENOMiHOG000115486
HOVERGENiHBG082116
InParanoidiO15018
OMAiHPYFTPR
OrthoDBiEOG091G0G6P
PhylomeDBiO15018
TreeFamiTF326303

Family and domain databases

InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
PfamiView protein in Pfam
PF00595 PDZ, 5 hits
SMARTiView protein in SMART
SM00228 PDZ, 6 hits
SUPFAMiSSF50156 SSF50156, 6 hits
PROSITEiView protein in PROSITE
PS50106 PDZ, 6 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O15018-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPITQDNAVL HLPLLYQWLQ NSLQEGGDGP EQRLCQAAIQ KLQEYIQLNF
60 70 80 90 100
AVDESTVPPD HSPPEMEICT VYLTKELGDT ETVGLSFGNI PVFGDYGEKR
110 120 130 140 150
RGGKKRKTHQ GPVLDVGCIW VTELRKNSPA GKSGKVRLRD EILSLNGQLM
160 170 180 190 200
VGVDVSGASY LAEQCWNGGF IYLIMLRRFK HKAHSTYNGN SSNSSEPGET
210 220 230 240 250
PTLELGDRTA KKGKRTRKFG VISRPPANKA PEESKGSAGC EVSSDPSTEL
260 270 280 290 300
ENGPDPELGN GHVFQLENGP DSLKEVAGPH LERSEVDRGT EHRIPKTDAP
310 320 330 340 350
LTTSNDKRRF SKGGKTDFQS SDCLAREEVG RIWKMELLKE SDGLGIQVSG
360 370 380 390 400
GRGSKRSPHA IVVTQVKEGG AAHRDGRLSL GDELLVINGH LLVGLSHEEA
410 420 430 440 450
VAILRSATGM VQLVVASKEN SAEDLLRLTS KSLPDLTSSV EDVSSWTDNE
460 470 480 490 500
DQEADGEEDE GTSSSVQRAM PGTDEPQDVC GAEESKGNLE SPKQGSNKIK
510 520 530 540 550
LKSRLSGGVH RLESVEEYNE LMVRNGDPRI RMLEVSRDGR KHSLPQLLDS
560 570 580 590 600
SSASQEYHIV KKSTRSLSTT QVESPWRLIR PSVISIIGLY KEKGKGLGFS
610 620 630 640 650
IAGGRDCIRG QMGIFVKTIF PNGSAAEDGR LKEGDEILDV NGIPIKGLTF
660 670 680 690 700
QEAIHTFKQI RSGLFVLTVR TKLVSPSLTP CSTPTHMSRS ASPNFNTSGG
710 720 730 740 750
ASAGGSDEGS SSSLGRKTPG PKDRIVMEVT LNKEPRVGLG IGACCLALEN
760 770 780 790 800
SPPGIYIHSL APGSVAKMES NLSRGDQILE VNSVNVRHAA LSKVHAILSK
810 820 830 840 850
CPPGPVRLVI GRHPNPKVSE QEMDEVIARS TYQESKEANS SPGLGTPLKS
860 870 880 890 900
PSLAKKDSLI SESELSQYFA HDVPGPLSDF MVAGSEDEDH PGSGCSTSEE
910 920 930 940 950
GSLPPSTSTH KEPGKPRANS LVTLGSHRAS GLFHKQVTVA RQASLPGSPQ
960 970 980 990 1000
ALRNPLLRQR KVGCYDANDA SDEEEFDREG DCISLPGALP GPIRPLSEDD
1010 1020 1030 1040 1050
PRRVSISSSK GMDVHNQEER PRKTLVSKAI SAPLLGSSVD LEESIPEGMV
1060 1070 1080 1090 1100
DAASYAANLT DSAEAPKGSP GSWWKKELSG SSSAPKLEYT VRTDTQSPTN
1110 1120 1130 1140 1150
TGSPSSPQQK SEGLGSRHRP VARVSPHCKR SEAEAKPSGS QTVNLTGRAN
1160 1170 1180 1190 1200
DPCDLDSRVQ ATSVKVTVAG FQPGGAVEKE SLGKLTTGDA CVSTSCELAS
1210 1220 1230 1240 1250
ALSHLDASHL TENLPKAASE LGQQPMTELD SSSDLISSPG KKGAAHPDPS
1260 1270 1280 1290 1300
KTSVDTGQVS RPENPSQPAS PRVTKCKARS PVRLPHEGSP SPGEKAAAPP
1310 1320 1330 1340 1350
DYSKTRSASE TSTPHNTRRV AALRGAGPGA EGMTPAGAVL PGDPLTSQEQ
1360 1370 1380 1390 1400
RQGAPGNHSK ALEMTGIHAP ESSQEPSLLE GADSVSSRAP QASLSMLPST
1410 1420 1430 1440 1450
DNTKEACGHV SGHCCPGGSR ESPVTDIDSF IKELDASAAR SPSSQTGDSG
1460 1470 1480 1490 1500
SQEGSAQGHP PAGAGGGSSC RAEPVPGGQT SSPRRAWAAG APAYPQWASQ
1510 1520 1530 1540 1550
PSVLDSINPD KHFTVNKNFL SNYSRNFSSF HEDSTSLSGL GDSTEPSLSS
1560 1570 1580 1590 1600
MYGDAEDSSS DPESLTEAPR ASARDGWSPP RSRVSLHKED PSESEEEQIE
1610 1620 1630 1640 1650
ICSTRGCPNP PSSPAHLPTQ AAICPASAKV LSLKYSTPRE SVASPREKAA
1660 1670 1680 1690 1700
CLPGSYTSGP DSSQPSSLLE MSSQEHETHA DISTSQNHRP SCAEETTEVT
1710 1720 1730 1740 1750
SASSAMENSP LSKVARHFHS PPIILSSPNM VNGLEHDLLD DETLNQYETS
1760 1770 1780 1790 1800
INAAASLSSF SVDVPKNGES VLENLHISES QDLDDLLQKP KMIARRPIMA
1810 1820 1830 1840 1850
WFKEINKHNQ GTHLRSKTEK EQPLMPARSP DSKIQMVSSS QKKGVTVPHS
1860 1870 1880 1890 1900
PPQPKTNLEN KDLSKKSPAE MLLTNGQKAK CGPKLKRLSL KGKAKVNSEA
1910 1920 1930 1940 1950
PAANAVKAGG TDHRKPLISP QTSHKTLSKA VSQRLHVADH EDPDRNTTAA
1960 1970 1980 1990 2000
PRSPQCVLES KPPLATSGPL KPSVSDTSIR TFVSPLTSPK PVPEQGMWSR
2010 2020 2030 2040 2050
FHMAVLSEPD RGCPTTPKSP KCRAEGRAPR ADSGPVSPAA SRNGMSVAGN
2060 2070 2080 2090 2100
RQSEPRLASH VAADTAQPRP TGEKGGNIMA SDRLERTNQL KIVEISAEAV
2110 2120 2130 2140 2150
SETVCGNKPA ESDRRGGCLA QGNCQEKSEI RLYRQVAESS TSHPSSLPSH
2160 2170 2180 2190 2200
ASQAEQEMSR SFSMAKLASS SSSLQTAIRK AEYSQGKSSL MSDSRGVPRN
2210 2220 2230 2240 2250
SIPGGPSGED HLYFTPRPAT RTYSMPAQFS SHFGREGHPP HSLGRSRDSQ
2260 2270 2280 2290 2300
VPVTSSVVPE AKASRGGLPS LANGQGIYSV KPLLDTSRNL PATDEGDIIS
2310 2320 2330 2340 2350
VQETSCLVTD KIKVTRRHYC YEQNWPHEST SFFSVKQRIK SFENLANADR
2360 2370 2380 2390 2400
PVAKSGASPF LSVSSKPPIG RRSSGSIVSG SLGHPGDAAA RLLRRSLSSC
2410 2420 2430 2440 2450
SENQSEAGTL LPQMAKSPSI MTLTISRQNP PETSSKGSDS ELKKSLGPLG
2460 2470 2480 2490 2500
IPTPTMTLAS PVKRNKSSVR HTQPSPVSRS KLQELRALSM PDLDKLCSED
2510 2520 2530 2540 2550
YSAGPSAVLF KTELEITPRR SPGPPAGGVS CPEKGGNRAC PGGSGPKTSA
2560 2570 2580 2590 2600
AETPSSASDT GEAAQDLPFR RSWSVNLDQL LVSAGDQQRL QSVLSSVGSK
2610 2620 2630 2640 2650
STILTLIQEA KAQSENEEDV CFIVLNRKEG SGLGFSVAGG TDVEPKSITV
2660 2670 2680 2690 2700
HRVFSQGAAS QEGTMNRGDF LLSVNGASLA GLAHGNVLKV LHQAQLHKDA
2710 2720 2730 2740 2750
LVVIKKGMDQ PRPSARQEPP TANGKGLLSR KTIPLEPGIG RSVAVHDALC
2760 2770 2780 2790 2800
VEVLKTSAGL GLSLDGGKSS VTGDGPLVIK RVYKGGAAEQ AGIIEAGDEI
2810 2820 2830
LAINGKPLVG LMHFDAWNIM KSVPEGPVQL LIRKHRNSS
Length:2,839
Mass (Da):301,641
Last modified:April 17, 2007 - v4
Checksum:i4B1CB91A9CE96267
GO
Isoform 2 (identifier: O15018-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     375-555: Missing.
     803-817: Missing.
     909-911: THK → S
     1179-1179: K → KLCQ
     1228-1231: Missing.

Note: May be due to aberrant splicing.
Show »
Length:2,640
Mass (Da):280,092
Checksum:i478AF0A0876DE2BE
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RF66D6RF66_HUMAN
PDZ domain-containing protein 2
PDZD2
13Annotation score:

Sequence cautioni

The sequence BAA20760 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti254P → A in AAK07661 (PubMed:11289102).Curated1
Sequence conflicti326R → RQ in AAK07661 (PubMed:11289102).Curated1
Sequence conflicti2576N → K in AAK07661 (PubMed:11289102).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0616911178E → G. Corresponds to variant dbSNP:rs57158698Ensembl.1
Natural variantiVAR_0316541258Q → K. Corresponds to variant dbSNP:rs3101878Ensembl.1
Natural variantiVAR_0316551274T → A1 PublicationCorresponds to variant dbSNP:rs157496Ensembl.1
Natural variantiVAR_0316561343D → E. Corresponds to variant dbSNP:rs12520467Ensembl.1
Natural variantiVAR_0316571425T → M. Corresponds to variant dbSNP:rs36097367Ensembl.1
Natural variantiVAR_0316581649A → V. Corresponds to variant dbSNP:rs3101873Ensembl.1
Natural variantiVAR_0316592247R → Q. Corresponds to variant dbSNP:rs10066063Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012369375 – 555Missing in isoform 2. 1 PublicationAdd BLAST181
Alternative sequenceiVSP_012370803 – 817Missing in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_012371909 – 911THK → S in isoform 2. 1 Publication3
Alternative sequenceiVSP_0123721179K → KLCQ in isoform 2. 1 Publication1
Alternative sequenceiVSP_0123731228 – 1231Missing in isoform 2. 1 Publication4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF338650 mRNA Translation: AAK07661.1
AB002298 mRNA Translation: BAA20760.2 Different initiation.
CCDSiCCDS34137.1 [O15018-1]
RefSeqiNP_835260.2, NM_178140.3 [O15018-1]
XP_011512297.1, XM_011513995.2 [O15018-1]
UniGeneiHs.481819

Genome annotation databases

EnsembliENST00000438447; ENSP00000402033; ENSG00000133401 [O15018-1]
GeneIDi23037
KEGGihsa:23037
UCSCiuc003jhl.4 human [O15018-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF338650 mRNA Translation: AAK07661.1
AB002298 mRNA Translation: BAA20760.2 Different initiation.
CCDSiCCDS34137.1 [O15018-1]
RefSeqiNP_835260.2, NM_178140.3 [O15018-1]
XP_011512297.1, XM_011513995.2 [O15018-1]
UniGeneiHs.481819

3D structure databases

ProteinModelPortaliO15018
SMRiO15018
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116676, 12 interactors
IntActiO15018, 3 interactors
STRINGi9606.ENSP00000282493

PTM databases

iPTMnetiO15018
PhosphoSitePlusiO15018

Polymorphism and mutation databases

BioMutaiPDZD2

Proteomic databases

EPDiO15018
MaxQBiO15018
PaxDbiO15018
PeptideAtlasiO15018
PRIDEiO15018
ProteomicsDBi48374
48375 [O15018-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000438447; ENSP00000402033; ENSG00000133401 [O15018-1]
GeneIDi23037
KEGGihsa:23037
UCSCiuc003jhl.4 human [O15018-1]

Organism-specific databases

CTDi23037
DisGeNETi23037
EuPathDBiHostDB:ENSG00000133401.15
GeneCardsiPDZD2
H-InvDBiHIX0004783
HGNCiHGNC:18486 PDZD2
HPAiCAB020784
HPA036503
HPA036504
HPA064387
MIMi610697 gene
neXtProtiNX_O15018
OpenTargetsiENSG00000133401
PharmGKBiPA33164
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0708 Eukaryota
KOG3528 Eukaryota
ENOG4110362 LUCA
GeneTreeiENSGT00760000119017
HOGENOMiHOG000115486
HOVERGENiHBG082116
InParanoidiO15018
OMAiHPYFTPR
OrthoDBiEOG091G0G6P
PhylomeDBiO15018
TreeFamiTF326303

Miscellaneous databases

ChiTaRSiPDZD2 human
GeneWikiiPDZD2
GenomeRNAii23037
PROiPR:O15018
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000133401 Expressed in 224 organ(s), highest expression level in caudate nucleus
CleanExiHS_PDZD2
ExpressionAtlasiO15018 baseline and differential
GenevisibleiO15018 HS

Family and domain databases

InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
PfamiView protein in Pfam
PF00595 PDZ, 5 hits
SMARTiView protein in SMART
SM00228 PDZ, 6 hits
SUPFAMiSSF50156 SSF50156, 6 hits
PROSITEiView protein in PROSITE
PS50106 PDZ, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPDZD2_HUMAN
AccessioniPrimary (citable) accession number: O15018
Secondary accession number(s): Q9BXD4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: April 17, 2007
Last modified: November 7, 2018
This is version 140 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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