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Protein

PDZ domain-containing protein 2

Gene

PDZD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PDZ domain-containing protein 2
Alternative name(s):
Activated in prostate cancer protein
PDZ domain-containing protein 3
Cleaved into the following chain:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PDZD2
Synonyms:AIPC, KIAA0300, PDZK3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000133401.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18486 PDZD2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610697 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O15018

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Nucleus, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23037

Open Targets

More...
OpenTargetsi
ENSG00000133401

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33164

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PDZD2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000582941 – 2839PDZ domain-containing protein 2Add BLAST2839
ChainiPRO_0000302756?2493 – 2839Processed PDZ domain-containing protein 2By similarityAdd BLAST347

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei568PhosphoserineBy similarity1
Modified residuei944PhosphoserineBy similarity1
Modified residuei948PhosphoserineBy similarity1
Modified residuei1850PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

A secreted form is produced by caspase-mediated proteolytic cleavage.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei2492 – 2493Cleavage; by caspasesBy similarity2

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O15018

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O15018

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O15018

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O15018

PeptideAtlas

More...
PeptideAtlasi
O15018

PRoteomics IDEntifications database

More...
PRIDEi
O15018

ProteomicsDB human proteome resource

More...
ProteomicsDBi
48374
48375 [O15018-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O15018

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O15018

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 2 is expressed (at protein level) in prostate and many prostate tumors.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000133401 Expressed in 224 organ(s), highest expression level in caudate nucleus

CleanEx database of gene expression profiles

More...
CleanExi
HS_PDZD2

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O15018 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O15018 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB020784
HPA036503
HPA036504
HPA064387

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SCN10A, CTNND2 and PKP4.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116676, 12 interactors

Protein interaction database and analysis system

More...
IntActi
O15018, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000282493

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O15018

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O15018

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini85 – 182PDZ 1PROSITE-ProRule annotationAdd BLAST98
Domaini334 – 419PDZ 2PROSITE-ProRule annotationAdd BLAST86
Domaini586 – 672PDZ 3PROSITE-ProRule annotationAdd BLAST87
Domaini728 – 813PDZ 4PROSITE-ProRule annotationAdd BLAST86
Domaini2622 – 2706PDZ 5PROSITE-ProRule annotationAdd BLAST85
Domaini2750 – 2835PDZ 6PROSITE-ProRule annotationAdd BLAST86

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2139 – 2194Ser-richAdd BLAST56

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0708 Eukaryota
KOG3528 Eukaryota
ENOG4110362 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157749

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000115486

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG082116

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O15018

Identification of Orthologs from Complete Genome Data

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OMAi
HPYFTPR

Database of Orthologous Groups

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OrthoDBi
225688at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O15018

TreeFam database of animal gene trees

More...
TreeFami
TF326303

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00595 PDZ, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228 PDZ, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50156 SSF50156, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50106 PDZ, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O15018-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPITQDNAVL HLPLLYQWLQ NSLQEGGDGP EQRLCQAAIQ KLQEYIQLNF
60 70 80 90 100
AVDESTVPPD HSPPEMEICT VYLTKELGDT ETVGLSFGNI PVFGDYGEKR
110 120 130 140 150
RGGKKRKTHQ GPVLDVGCIW VTELRKNSPA GKSGKVRLRD EILSLNGQLM
160 170 180 190 200
VGVDVSGASY LAEQCWNGGF IYLIMLRRFK HKAHSTYNGN SSNSSEPGET
210 220 230 240 250
PTLELGDRTA KKGKRTRKFG VISRPPANKA PEESKGSAGC EVSSDPSTEL
260 270 280 290 300
ENGPDPELGN GHVFQLENGP DSLKEVAGPH LERSEVDRGT EHRIPKTDAP
310 320 330 340 350
LTTSNDKRRF SKGGKTDFQS SDCLAREEVG RIWKMELLKE SDGLGIQVSG
360 370 380 390 400
GRGSKRSPHA IVVTQVKEGG AAHRDGRLSL GDELLVINGH LLVGLSHEEA
410 420 430 440 450
VAILRSATGM VQLVVASKEN SAEDLLRLTS KSLPDLTSSV EDVSSWTDNE
460 470 480 490 500
DQEADGEEDE GTSSSVQRAM PGTDEPQDVC GAEESKGNLE SPKQGSNKIK
510 520 530 540 550
LKSRLSGGVH RLESVEEYNE LMVRNGDPRI RMLEVSRDGR KHSLPQLLDS
560 570 580 590 600
SSASQEYHIV KKSTRSLSTT QVESPWRLIR PSVISIIGLY KEKGKGLGFS
610 620 630 640 650
IAGGRDCIRG QMGIFVKTIF PNGSAAEDGR LKEGDEILDV NGIPIKGLTF
660 670 680 690 700
QEAIHTFKQI RSGLFVLTVR TKLVSPSLTP CSTPTHMSRS ASPNFNTSGG
710 720 730 740 750
ASAGGSDEGS SSSLGRKTPG PKDRIVMEVT LNKEPRVGLG IGACCLALEN
760 770 780 790 800
SPPGIYIHSL APGSVAKMES NLSRGDQILE VNSVNVRHAA LSKVHAILSK
810 820 830 840 850
CPPGPVRLVI GRHPNPKVSE QEMDEVIARS TYQESKEANS SPGLGTPLKS
860 870 880 890 900
PSLAKKDSLI SESELSQYFA HDVPGPLSDF MVAGSEDEDH PGSGCSTSEE
910 920 930 940 950
GSLPPSTSTH KEPGKPRANS LVTLGSHRAS GLFHKQVTVA RQASLPGSPQ
960 970 980 990 1000
ALRNPLLRQR KVGCYDANDA SDEEEFDREG DCISLPGALP GPIRPLSEDD
1010 1020 1030 1040 1050
PRRVSISSSK GMDVHNQEER PRKTLVSKAI SAPLLGSSVD LEESIPEGMV
1060 1070 1080 1090 1100
DAASYAANLT DSAEAPKGSP GSWWKKELSG SSSAPKLEYT VRTDTQSPTN
1110 1120 1130 1140 1150
TGSPSSPQQK SEGLGSRHRP VARVSPHCKR SEAEAKPSGS QTVNLTGRAN
1160 1170 1180 1190 1200
DPCDLDSRVQ ATSVKVTVAG FQPGGAVEKE SLGKLTTGDA CVSTSCELAS
1210 1220 1230 1240 1250
ALSHLDASHL TENLPKAASE LGQQPMTELD SSSDLISSPG KKGAAHPDPS
1260 1270 1280 1290 1300
KTSVDTGQVS RPENPSQPAS PRVTKCKARS PVRLPHEGSP SPGEKAAAPP
1310 1320 1330 1340 1350
DYSKTRSASE TSTPHNTRRV AALRGAGPGA EGMTPAGAVL PGDPLTSQEQ
1360 1370 1380 1390 1400
RQGAPGNHSK ALEMTGIHAP ESSQEPSLLE GADSVSSRAP QASLSMLPST
1410 1420 1430 1440 1450
DNTKEACGHV SGHCCPGGSR ESPVTDIDSF IKELDASAAR SPSSQTGDSG
1460 1470 1480 1490 1500
SQEGSAQGHP PAGAGGGSSC RAEPVPGGQT SSPRRAWAAG APAYPQWASQ
1510 1520 1530 1540 1550
PSVLDSINPD KHFTVNKNFL SNYSRNFSSF HEDSTSLSGL GDSTEPSLSS
1560 1570 1580 1590 1600
MYGDAEDSSS DPESLTEAPR ASARDGWSPP RSRVSLHKED PSESEEEQIE
1610 1620 1630 1640 1650
ICSTRGCPNP PSSPAHLPTQ AAICPASAKV LSLKYSTPRE SVASPREKAA
1660 1670 1680 1690 1700
CLPGSYTSGP DSSQPSSLLE MSSQEHETHA DISTSQNHRP SCAEETTEVT
1710 1720 1730 1740 1750
SASSAMENSP LSKVARHFHS PPIILSSPNM VNGLEHDLLD DETLNQYETS
1760 1770 1780 1790 1800
INAAASLSSF SVDVPKNGES VLENLHISES QDLDDLLQKP KMIARRPIMA
1810 1820 1830 1840 1850
WFKEINKHNQ GTHLRSKTEK EQPLMPARSP DSKIQMVSSS QKKGVTVPHS
1860 1870 1880 1890 1900
PPQPKTNLEN KDLSKKSPAE MLLTNGQKAK CGPKLKRLSL KGKAKVNSEA
1910 1920 1930 1940 1950
PAANAVKAGG TDHRKPLISP QTSHKTLSKA VSQRLHVADH EDPDRNTTAA
1960 1970 1980 1990 2000
PRSPQCVLES KPPLATSGPL KPSVSDTSIR TFVSPLTSPK PVPEQGMWSR
2010 2020 2030 2040 2050
FHMAVLSEPD RGCPTTPKSP KCRAEGRAPR ADSGPVSPAA SRNGMSVAGN
2060 2070 2080 2090 2100
RQSEPRLASH VAADTAQPRP TGEKGGNIMA SDRLERTNQL KIVEISAEAV
2110 2120 2130 2140 2150
SETVCGNKPA ESDRRGGCLA QGNCQEKSEI RLYRQVAESS TSHPSSLPSH
2160 2170 2180 2190 2200
ASQAEQEMSR SFSMAKLASS SSSLQTAIRK AEYSQGKSSL MSDSRGVPRN
2210 2220 2230 2240 2250
SIPGGPSGED HLYFTPRPAT RTYSMPAQFS SHFGREGHPP HSLGRSRDSQ
2260 2270 2280 2290 2300
VPVTSSVVPE AKASRGGLPS LANGQGIYSV KPLLDTSRNL PATDEGDIIS
2310 2320 2330 2340 2350
VQETSCLVTD KIKVTRRHYC YEQNWPHEST SFFSVKQRIK SFENLANADR
2360 2370 2380 2390 2400
PVAKSGASPF LSVSSKPPIG RRSSGSIVSG SLGHPGDAAA RLLRRSLSSC
2410 2420 2430 2440 2450
SENQSEAGTL LPQMAKSPSI MTLTISRQNP PETSSKGSDS ELKKSLGPLG
2460 2470 2480 2490 2500
IPTPTMTLAS PVKRNKSSVR HTQPSPVSRS KLQELRALSM PDLDKLCSED
2510 2520 2530 2540 2550
YSAGPSAVLF KTELEITPRR SPGPPAGGVS CPEKGGNRAC PGGSGPKTSA
2560 2570 2580 2590 2600
AETPSSASDT GEAAQDLPFR RSWSVNLDQL LVSAGDQQRL QSVLSSVGSK
2610 2620 2630 2640 2650
STILTLIQEA KAQSENEEDV CFIVLNRKEG SGLGFSVAGG TDVEPKSITV
2660 2670 2680 2690 2700
HRVFSQGAAS QEGTMNRGDF LLSVNGASLA GLAHGNVLKV LHQAQLHKDA
2710 2720 2730 2740 2750
LVVIKKGMDQ PRPSARQEPP TANGKGLLSR KTIPLEPGIG RSVAVHDALC
2760 2770 2780 2790 2800
VEVLKTSAGL GLSLDGGKSS VTGDGPLVIK RVYKGGAAEQ AGIIEAGDEI
2810 2820 2830
LAINGKPLVG LMHFDAWNIM KSVPEGPVQL LIRKHRNSS
Length:2,839
Mass (Da):301,641
Last modified:April 17, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4B1CB91A9CE96267
GO
Isoform 2 (identifier: O15018-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     375-555: Missing.
     803-817: Missing.
     909-911: THK → S
     1179-1179: K → KLCQ
     1228-1231: Missing.

Note: May be due to aberrant splicing.
Show »
Length:2,640
Mass (Da):280,092
Checksum:i478AF0A0876DE2BE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RF66D6RF66_HUMAN
PDZ domain-containing protein 2
PDZD2
13Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA20760 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti254P → A in AAK07661 (PubMed:11289102).Curated1
Sequence conflicti326R → RQ in AAK07661 (PubMed:11289102).Curated1
Sequence conflicti2576N → K in AAK07661 (PubMed:11289102).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0616911178E → G. Corresponds to variant dbSNP:rs57158698Ensembl.1
Natural variantiVAR_0316541258Q → K. Corresponds to variant dbSNP:rs3101878Ensembl.1
Natural variantiVAR_0316551274T → A1 PublicationCorresponds to variant dbSNP:rs157496Ensembl.1
Natural variantiVAR_0316561343D → E. Corresponds to variant dbSNP:rs12520467Ensembl.1
Natural variantiVAR_0316571425T → M. Corresponds to variant dbSNP:rs36097367Ensembl.1
Natural variantiVAR_0316581649A → V. Corresponds to variant dbSNP:rs3101873Ensembl.1
Natural variantiVAR_0316592247R → Q. Corresponds to variant dbSNP:rs10066063Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_012369375 – 555Missing in isoform 2. 1 PublicationAdd BLAST181
Alternative sequenceiVSP_012370803 – 817Missing in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_012371909 – 911THK → S in isoform 2. 1 Publication3
Alternative sequenceiVSP_0123721179K → KLCQ in isoform 2. 1 Publication1
Alternative sequenceiVSP_0123731228 – 1231Missing in isoform 2. 1 Publication4

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF338650 mRNA Translation: AAK07661.1
AB002298 mRNA Translation: BAA20760.2 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS34137.1 [O15018-1]

NCBI Reference Sequences

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RefSeqi
NP_835260.2, NM_178140.3 [O15018-1]
XP_011512297.1, XM_011513995.2 [O15018-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.481819

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000438447; ENSP00000402033; ENSG00000133401 [O15018-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23037

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23037

UCSC genome browser

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UCSCi
uc003jhl.4 human [O15018-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF338650 mRNA Translation: AAK07661.1
AB002298 mRNA Translation: BAA20760.2 Different initiation.
CCDSiCCDS34137.1 [O15018-1]
RefSeqiNP_835260.2, NM_178140.3 [O15018-1]
XP_011512297.1, XM_011513995.2 [O15018-1]
UniGeneiHs.481819

3D structure databases

ProteinModelPortaliO15018
SMRiO15018
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116676, 12 interactors
IntActiO15018, 3 interactors
STRINGi9606.ENSP00000282493

PTM databases

iPTMnetiO15018
PhosphoSitePlusiO15018

Polymorphism and mutation databases

BioMutaiPDZD2

Proteomic databases

EPDiO15018
jPOSTiO15018
MaxQBiO15018
PaxDbiO15018
PeptideAtlasiO15018
PRIDEiO15018
ProteomicsDBi48374
48375 [O15018-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000438447; ENSP00000402033; ENSG00000133401 [O15018-1]
GeneIDi23037
KEGGihsa:23037
UCSCiuc003jhl.4 human [O15018-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23037
DisGeNETi23037
EuPathDBiHostDB:ENSG00000133401.15

GeneCards: human genes, protein and diseases

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GeneCardsi
PDZD2

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0004783
HGNCiHGNC:18486 PDZD2
HPAiCAB020784
HPA036503
HPA036504
HPA064387
MIMi610697 gene
neXtProtiNX_O15018
OpenTargetsiENSG00000133401
PharmGKBiPA33164

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0708 Eukaryota
KOG3528 Eukaryota
ENOG4110362 LUCA
GeneTreeiENSGT00940000157749
HOGENOMiHOG000115486
HOVERGENiHBG082116
InParanoidiO15018
OMAiHPYFTPR
OrthoDBi225688at2759
PhylomeDBiO15018
TreeFamiTF326303

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PDZD2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PDZD2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23037

Protein Ontology

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PROi
PR:O15018

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000133401 Expressed in 224 organ(s), highest expression level in caudate nucleus
CleanExiHS_PDZD2
ExpressionAtlasiO15018 baseline and differential
GenevisibleiO15018 HS

Family and domain databases

InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
PfamiView protein in Pfam
PF00595 PDZ, 5 hits
SMARTiView protein in SMART
SM00228 PDZ, 6 hits
SUPFAMiSSF50156 SSF50156, 6 hits
PROSITEiView protein in PROSITE
PS50106 PDZ, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPDZD2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15018
Secondary accession number(s): Q9BXD4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: April 17, 2007
Last modified: January 16, 2019
This is version 142 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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