UniProtKB - O15016 (TRI66_HUMAN)
Protein
Tripartite motif-containing protein 66
Gene
TRIM66
Organism
Homo sapiens (Human)
Status
Functioni
May function as transcription repressor; The repressive effects are mediated, at least in part, by recruitment of deacetylase activity. May play a role as negative regulator of postmeiotic genes acting through CBX3 complex formation and centromere association (By similarity).By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1 – 46 | B box-type 1; atypicalPROSITE-ProRule annotationAdd BLAST | 46 | |
Zinc fingeri | 60 – 101 | B box-type 2PROSITE-ProRule annotationAdd BLAST | 42 | |
Zinc fingeri | 970 – 1017 | PHD-typePROSITE-ProRule annotationAdd BLAST | 48 |
GO - Molecular functioni
- chromatin binding Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- negative regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Tripartite motif-containing protein 66 |
Gene namesi | Name:TRIM66 Synonyms:C11orf29, KIAA0298 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000166436.15 |
HGNCi | HGNC:29005 TRIM66 |
MIMi | 612000 gene |
neXtProti | NX_O15016 |
Subcellular locationi
Nucleus
Note: Forms discrete foci within the centromeric chromocenter and surrounding nucleoplasm.By similarity
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Other locations
- aggresome Source: HPA
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 9866 |
OpenTargetsi | ENSG00000166436 |
PharmGKBi | PA134954583 |
Polymorphism and mutation databases
BioMutai | TRIM66 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000220375 | 1 – 1216 | Tripartite motif-containing protein 66Add BLAST | 1216 |
Proteomic databases
jPOSTi | O15016 |
PaxDbi | O15016 |
PeptideAtlasi | O15016 |
PRIDEi | O15016 |
ProteomicsDBi | 48372 48373 [O15016-2] |
PTM databases
iPTMneti | O15016 |
PhosphoSitePlusi | O15016 |
Expressioni
Gene expression databases
Bgeei | ENSG00000166436 Expressed in 179 organ(s), highest expression level in testis |
ExpressionAtlasi | O15016 baseline and differential |
Genevisiblei | O15016 HS |
Organism-specific databases
HPAi | HPA027420 |
Interactioni
Subunit structurei
Can form homodimers and heterodimers. Interacts with CBX5, CBX1 and CBX3 via PxVxL motif (By similarity).By similarity
Protein-protein interaction databases
IntActi | O15016, 2 interactors |
STRINGi | 9606.ENSP00000384876 |
Structurei
3D structure databases
ProteinModelPortali | O15016 |
SMRi | O15016 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1056 – 1128 | BromoPROSITE-ProRule annotationAdd BLAST | 73 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 130 – 200 | Sequence analysisAdd BLAST | 71 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 860 – 864 | PxVxL motif | 5 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 384 – 571 | Gln-richAdd BLAST | 188 | |
Compositional biasi | 453 – 499 | Pro-richAdd BLAST | 47 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1 – 46 | B box-type 1; atypicalPROSITE-ProRule annotationAdd BLAST | 46 | |
Zinc fingeri | 60 – 101 | B box-type 2PROSITE-ProRule annotationAdd BLAST | 42 | |
Zinc fingeri | 970 – 1017 | PHD-typePROSITE-ProRule annotationAdd BLAST | 48 |
Keywords - Domaini
Bromodomain, Coiled coil, Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG2177 Eukaryota ENOG41106NJ LUCA |
GeneTreei | ENSGT00940000159240 |
HOGENOMi | HOG000074104 |
HOVERGENi | HBG057849 |
InParanoidi | O15016 |
KOi | K12032 |
OrthoDBi | 756911at2759 |
PhylomeDBi | O15016 |
Family and domain databases
CDDi | cd00021 BBOX, 1 hit |
Gene3Di | 1.20.920.10, 1 hit |
InterProi | View protein in InterPro IPR003649 Bbox_C IPR001487 Bromodomain IPR036427 Bromodomain-like_sf IPR037372 Trim66 IPR019786 Zinc_finger_PHD-type_CS IPR000315 Znf_B-box IPR011011 Znf_FYVE_PHD IPR001965 Znf_PHD IPR019787 Znf_PHD-finger |
PANTHERi | PTHR45154 PTHR45154, 2 hits |
Pfami | View protein in Pfam PF00439 Bromodomain, 1 hit PF00628 PHD, 1 hit PF00643 zf-B_box, 1 hit |
SMARTi | View protein in SMART SM00502 BBC, 1 hit SM00336 BBOX, 2 hits SM00297 BROMO, 1 hit SM00249 PHD, 2 hits |
SUPFAMi | SSF47370 SSF47370, 1 hit SSF57903 SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS50014 BROMODOMAIN_2, 1 hit PS50119 ZF_BBOX, 2 hits PS01359 ZF_PHD_1, 1 hit PS50016 ZF_PHD_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O15016-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MARNCSECKE KRAAHILCTY CNRWLCSSCT EEHRHSPVPG GPFFPRAQKG
60 70 80 90 100
SPGVNGGPGD FTLYCPLHTQ EVLKLFCETC DMLTCHSCLV VEHKEHRCRH
110 120 130 140 150
VEEVLQNQRM LLEGVTTQVA HKKSSLQTSA KQIEDRIFEV KHQHRKVENQ
160 170 180 190 200
IKMAKMVLMN ELNKQANGLI EELEGITNER KRKLEQQLQS IMVLNRQFEH
210 220 230 240 250
VQNFINWAVC SKTSVPFLFS KELIVFQMQR LLETSCNTDP GSPWSIRFTW
260 270 280 290 300
EPNFWTKQLA SLGCITTEGG QMSRADAPAY GGLQGSSPFY QSHQSPVAQQ
310 320 330 340 350
EALSHPSHKF QSPAVCSSSV CCSHCSPVSP SLKGQVPPPS IHPAHSFRQP
360 370 380 390 400
PEMVPQQLGS LQCSALLPRE KELACSPHPP KLLQPWLETQ PPVEQESTSQ
410 420 430 440 450
RLGQQLTSQP VCIVPPQDVQ QGAHAQPTLQ TPSIQVQFGH HQKLKLSHFQ
460 470 480 490 500
QQPQQQLPPP PPPLPHPPPP LPPPPQQPHP PLPPSQHLAS SQHESPPGPA
510 520 530 540 550
CSQNMDIMHH KFELEEMQKD LELLLQAQQP SLQLSQTKSP QHLQQTIVGQ
560 570 580 590 600
INYIVRQPAP VQSQSQEETL QATDEPPASQ GSKPALPLDK NTAAALPQAS
610 620 630 640 650
GEETPLSVPP VDSTIQHSSP NVVRKHSTSL SIMGFSNTLE MELSSTRLER
660 670 680 690 700
PLEPQIQSVS NLTAGAPQAV PSLLSAPPKM VSSLTSVQNQ AMPSLTTSHL
710 720 730 740 750
QTVPSLVHST FQSMPNLISD SPQAMASLAS DHPQAGPSLM SGHTQAVPSL
760 770 780 790 800
ATCPLQSIPP VSDMQPETGS SSSSGRTSGS LCPRDGADPS LENALCKVKL
810 820 830 840 850
EEPINLSVKK PPLAPVVSTS TALQQYQNPK ECENFEQGAL ELDAKENQSI
860 870 880 890 900
RAFNSEHKIP YVRLERLKIC AASSGEMPVF KLKPQKNDQD GSFLLIIECG
910 920 930 940 950
TESSSMSIKV SQDRLSEATQ APGLEGRKVT VTSLAGQRPP EVEGTSPEEH
960 970 980 990 1000
RLIPRTPGAK KGPPAPIENE DFCAVCLNGG ELLCCDRCPK VFHLSCHVPA
1010 1020 1030 1040 1050
LLSFPGGEWV CTLCRSLTQP EMEYDCENAC YNQPGMRASP GLSMYDQKKC
1060 1070 1080 1090 1100
EKLVLSLCCN NLSLPFHEPV SPLARHYYQI IKRPMDLSII RRKLQKKDPA
1110 1120 1130 1140 1150
HYTTPEEVVS DVRLMFWNCA KFNYPDSEVA EAGRCLEVFF EGWLKEIYPE
1160 1170 1180 1190 1200
KRFAQPRQED SDSEEVSSES GCSTPQGFPW PPYMQEGIQP KRRRRHMENE
1210
RAKRMSFRLA NSISQV
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB5MCJ9 | B5MCJ9_HUMAN | Tripartite motif-containing protein... | TRIM66 | 1,245 | Annotation score: | ||
A0A2R8YEA1 | A0A2R8YEA1_HUMAN | Tripartite motif-containing protein... | TRIM66 | 1,392 | Annotation score: | ||
H0YF52 | H0YF52_HUMAN | Tripartite motif-containing protein... | TRIM66 | 286 | Annotation score: | ||
A0A2R8YE93 | A0A2R8YE93_HUMAN | Tripartite motif-containing protein... | TRIM66 | 36 | Annotation score: |
Sequence cautioni
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_038386 | 97 – 98 | Missing in isoform 2. 1 Publication | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ400879 Genomic DNA Translation: CAC35389.1 AB002296 mRNA Translation: BAA20758.2 Frameshift. AC091053 Genomic DNA No translation available. AC104360 Genomic DNA No translation available. |
RefSeqi | NP_055633.1, NM_014818.1 [O15016-1] |
UniGenei | Hs.130836 Hs.716965 |
Genome annotation databases
Ensembli | ENST00000299550; ENSP00000299550; ENSG00000166436 [O15016-1] |
GeneIDi | 9866 |
KEGGi | hsa:9866 |
UCSCi | uc010rbo.2 human [O15016-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ400879 Genomic DNA Translation: CAC35389.1 AB002296 mRNA Translation: BAA20758.2 Frameshift. AC091053 Genomic DNA No translation available. AC104360 Genomic DNA No translation available. |
RefSeqi | NP_055633.1, NM_014818.1 [O15016-1] |
UniGenei | Hs.130836 Hs.716965 |
3D structure databases
ProteinModelPortali | O15016 |
SMRi | O15016 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
IntActi | O15016, 2 interactors |
STRINGi | 9606.ENSP00000384876 |
PTM databases
iPTMneti | O15016 |
PhosphoSitePlusi | O15016 |
Polymorphism and mutation databases
BioMutai | TRIM66 |
Proteomic databases
jPOSTi | O15016 |
PaxDbi | O15016 |
PeptideAtlasi | O15016 |
PRIDEi | O15016 |
ProteomicsDBi | 48372 48373 [O15016-2] |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000299550; ENSP00000299550; ENSG00000166436 [O15016-1] |
GeneIDi | 9866 |
KEGGi | hsa:9866 |
UCSCi | uc010rbo.2 human [O15016-1] |
Organism-specific databases
CTDi | 9866 |
DisGeNETi | 9866 |
EuPathDBi | HostDB:ENSG00000166436.15 |
GeneCardsi | TRIM66 |
H-InvDBi | HIX0201585 |
HGNCi | HGNC:29005 TRIM66 |
HPAi | HPA027420 |
MIMi | 612000 gene |
neXtProti | NX_O15016 |
OpenTargetsi | ENSG00000166436 |
PharmGKBi | PA134954583 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2177 Eukaryota ENOG41106NJ LUCA |
GeneTreei | ENSGT00940000159240 |
HOGENOMi | HOG000074104 |
HOVERGENi | HBG057849 |
InParanoidi | O15016 |
KOi | K12032 |
OrthoDBi | 756911at2759 |
PhylomeDBi | O15016 |
Miscellaneous databases
ChiTaRSi | TRIM66 human |
GenomeRNAii | 9866 |
PROi | PR:O15016 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000166436 Expressed in 179 organ(s), highest expression level in testis |
ExpressionAtlasi | O15016 baseline and differential |
Genevisiblei | O15016 HS |
Family and domain databases
CDDi | cd00021 BBOX, 1 hit |
Gene3Di | 1.20.920.10, 1 hit |
InterProi | View protein in InterPro IPR003649 Bbox_C IPR001487 Bromodomain IPR036427 Bromodomain-like_sf IPR037372 Trim66 IPR019786 Zinc_finger_PHD-type_CS IPR000315 Znf_B-box IPR011011 Znf_FYVE_PHD IPR001965 Znf_PHD IPR019787 Znf_PHD-finger |
PANTHERi | PTHR45154 PTHR45154, 2 hits |
Pfami | View protein in Pfam PF00439 Bromodomain, 1 hit PF00628 PHD, 1 hit PF00643 zf-B_box, 1 hit |
SMARTi | View protein in SMART SM00502 BBC, 1 hit SM00336 BBOX, 2 hits SM00297 BROMO, 1 hit SM00249 PHD, 2 hits |
SUPFAMi | SSF47370 SSF47370, 1 hit SSF57903 SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS50014 BROMODOMAIN_2, 1 hit PS50119 ZF_BBOX, 2 hits PS01359 ZF_PHD_1, 1 hit PS50016 ZF_PHD_2, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | TRI66_HUMAN | |
Accessioni | O15016Primary (citable) accession number: O15016 Secondary accession number(s): Q9BQQ4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | November 24, 2009 | |
Last modified: | February 13, 2019 | |
This is version 143 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot