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UniProtKB - O15016 (TRI66_HUMAN)

Entry version 157 (02 Jun 2021)
Sequence version 4 (24 Nov 2009)
Previous versions | rss
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Protein

Tripartite motif-containing protein 66

Gene

TRIM66

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as transcription repressor; The repressive effects are mediated, at least in part, by recruitment of deacetylase activity. May play a role as negative regulator of postmeiotic genes acting through CBX3 complex formation and centromere association (By similarity).

By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi5Zinc 1PROSITE-ProRule annotation1
Metal bindingi8Zinc 1PROSITE-ProRule annotation1
Metal bindingi29Zinc 1PROSITE-ProRule annotation1
Metal bindingi35Zinc 1PROSITE-ProRule annotation1
Metal bindingi65Zinc 2PROSITE-ProRule annotation1
Metal bindingi68Zinc 2PROSITE-ProRule annotation1
Metal bindingi88Zinc 2PROSITE-ProRule annotation1
Metal bindingi93Zinc 2PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1 – 46B box-type 1; atypicalPROSITE-ProRule annotationAdd BLAST46
Zinc fingeri60 – 101B box-type 2PROSITE-ProRule annotationAdd BLAST42
Zinc fingeri970 – 1017PHD-typePROSITE-ProRule annotationAdd BLAST48

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O15016

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tripartite motif-containing protein 66
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRIM66
Synonyms:C11orf29, KIAA0298
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:29005, TRIM66

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		612000, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O15016

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000166436.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		9866

Open Targets

More...OpenTargetsi		ENSG00000166436

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134954583

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O15016, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TRIM66

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002203751 – 1216Tripartite motif-containing protein 66Add BLAST1216

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O15016

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O15016

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O15016

PeptideAtlas

More...PeptideAtlasi		O15016

PRoteomics IDEntifications database

More...PRIDEi		O15016

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		48372 [O15016-1]
48373 [O15016-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O15016

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O15016

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000166436, Expressed in sural nerve and 192 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O15016, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O15016, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000166436, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Can form homodimers and heterodimers.

Interacts with CBX5, CBX1 and CBX3 via PxVxL motif (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115199, 200 interactors

Protein interaction database and analysis system

More...IntActi		O15016, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000384876

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O15016, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11216
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O15016

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1056 – 1128BromoPROSITE-ProRule annotationAdd BLAST73

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni438 – 504DisorderedSequence analysisAdd BLAST67
Regioni559 – 626DisorderedSequence analysisAdd BLAST68
Regioni753 – 786DisorderedSequence analysisAdd BLAST34
Regioni932 – 963DisorderedSequence analysisAdd BLAST32
Regioni1154 – 1216DisorderedSequence analysisAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili130 – 200Sequence analysisAdd BLAST71

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi860 – 864PxVxL motif5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi438 – 453Polar residuesSequence analysisAdd BLAST16
Compositional biasi454 – 485Pro residuesSequence analysisAdd BLAST32
Compositional biasi559 – 578Polar residuesSequence analysisAdd BLAST20
Compositional biasi607 – 626Polar residuesSequence analysisAdd BLAST20
Compositional biasi753 – 780Polar residuesSequence analysisAdd BLAST28
Compositional biasi1188 – 1205Basic and acidic residuesSequence analysisAdd BLAST18

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 46B box-type 1; atypicalPROSITE-ProRule annotationAdd BLAST46
Zinc fingeri60 – 101B box-type 2PROSITE-ProRule annotationAdd BLAST42
Zinc fingeri970 – 1017PHD-typePROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Bromodomain, Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2177, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159240

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005817_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O15016

Database of Orthologous Groups

More...OrthoDBi		756911at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O15016

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.920.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003649, Bbox_C
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR037372, Trim66
IPR019786, Zinc_finger_PHD-type_CS
IPR000315, Znf_B-box
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger

The PANTHER Classification System

More...PANTHERi		PTHR45915:SF7, PTHR45915:SF7, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00439, Bromodomain, 1 hit
PF00628, PHD, 1 hit
PF00643, zf-B_box, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00502, BBC, 1 hit
SM00336, BBOX, 2 hits
SM00297, BROMO, 1 hit
SM00249, PHD, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47370, SSF47370, 1 hit
SSF57903, SSF57903, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50014, BROMODOMAIN_2, 1 hit
PS50119, ZF_BBOX, 2 hits
PS01359, ZF_PHD_1, 1 hit
PS50016, ZF_PHD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O15016-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARNCSECKE KRAAHILCTY CNRWLCSSCT EEHRHSPVPG GPFFPRAQKG 
        60         70         80         90        100
SPGVNGGPGD FTLYCPLHTQ EVLKLFCETC DMLTCHSCLV VEHKEHRCRH 
       110        120        130        140        150
VEEVLQNQRM LLEGVTTQVA HKKSSLQTSA KQIEDRIFEV KHQHRKVENQ 
       160        170        180        190        200
IKMAKMVLMN ELNKQANGLI EELEGITNER KRKLEQQLQS IMVLNRQFEH 
       210        220        230        240        250
VQNFINWAVC SKTSVPFLFS KELIVFQMQR LLETSCNTDP GSPWSIRFTW 
       260        270        280        290        300
EPNFWTKQLA SLGCITTEGG QMSRADAPAY GGLQGSSPFY QSHQSPVAQQ 
       310        320        330        340        350
EALSHPSHKF QSPAVCSSSV CCSHCSPVSP SLKGQVPPPS IHPAHSFRQP 
       360        370        380        390        400
PEMVPQQLGS LQCSALLPRE KELACSPHPP KLLQPWLETQ PPVEQESTSQ 
       410        420        430        440        450
RLGQQLTSQP VCIVPPQDVQ QGAHAQPTLQ TPSIQVQFGH HQKLKLSHFQ 
       460        470        480        490        500
QQPQQQLPPP PPPLPHPPPP LPPPPQQPHP PLPPSQHLAS SQHESPPGPA 
       510        520        530        540        550
CSQNMDIMHH KFELEEMQKD LELLLQAQQP SLQLSQTKSP QHLQQTIVGQ 
       560        570        580        590        600
INYIVRQPAP VQSQSQEETL QATDEPPASQ GSKPALPLDK NTAAALPQAS 
       610        620        630        640        650
GEETPLSVPP VDSTIQHSSP NVVRKHSTSL SIMGFSNTLE MELSSTRLER 
       660        670        680        690        700
PLEPQIQSVS NLTAGAPQAV PSLLSAPPKM VSSLTSVQNQ AMPSLTTSHL 
       710        720        730        740        750
QTVPSLVHST FQSMPNLISD SPQAMASLAS DHPQAGPSLM SGHTQAVPSL 
       760        770        780        790        800
ATCPLQSIPP VSDMQPETGS SSSSGRTSGS LCPRDGADPS LENALCKVKL 
       810        820        830        840        850
EEPINLSVKK PPLAPVVSTS TALQQYQNPK ECENFEQGAL ELDAKENQSI 
       860        870        880        890        900
RAFNSEHKIP YVRLERLKIC AASSGEMPVF KLKPQKNDQD GSFLLIIECG 
       910        920        930        940        950
TESSSMSIKV SQDRLSEATQ APGLEGRKVT VTSLAGQRPP EVEGTSPEEH 
       960        970        980        990       1000
RLIPRTPGAK KGPPAPIENE DFCAVCLNGG ELLCCDRCPK VFHLSCHVPA 
      1010       1020       1030       1040       1050
LLSFPGGEWV CTLCRSLTQP EMEYDCENAC YNQPGMRASP GLSMYDQKKC 
      1060       1070       1080       1090       1100
EKLVLSLCCN NLSLPFHEPV SPLARHYYQI IKRPMDLSII RRKLQKKDPA 
      1110       1120       1130       1140       1150
HYTTPEEVVS DVRLMFWNCA KFNYPDSEVA EAGRCLEVFF EGWLKEIYPE 
      1160       1170       1180       1190       1200
KRFAQPRQED SDSEEVSSES GCSTPQGFPW PPYMQEGIQP KRRRRHMENE 
      1210 
RAKRMSFRLA NSISQV
Length:1,216
Mass (Da):134,663
Last modified:November 24, 2009 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5E0F4953230617D1
GO
Isoform 2 (identifier: O15016-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     97-98: Missing.

Show »
Length:1,214
Mass (Da):134,404
Checksum:iA3973C0EA2D47C3A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B5MCJ9B5MCJ9_HUMAN
Tripartite motif-containing protein...
TRIM66
1,245Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YEA1A0A2R8YEA1_HUMAN
Tripartite motif-containing protein...
TRIM66
1,392Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YF52H0YF52_HUMAN
Tripartite motif-containing protein...
TRIM66
286Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YE93A0A2R8YE93_HUMAN
Tripartite motif-containing protein...
TRIM66
36Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA20758 differs from that shown. Reason: Frameshift.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03838697 – 98Missing in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ400879 Genomic DNA Translation: CAC35389.1
AB002296 mRNA Translation: BAA20758.2 Frameshift.
AC091053 Genomic DNA No translation available.
AC104360 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		NP_055633.1, NM_014818.1 [O15016-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000299550; ENSP00000299550; ENSG00000166436 [O15016-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9866

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9866

UCSC genome browser

More...UCSCi		uc010rbo.2, human [O15016-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ400879 Genomic DNA Translation: CAC35389.1
AB002296 mRNA Translation: BAA20758.2 Frameshift.
AC091053 Genomic DNA No translation available.
AC104360 Genomic DNA No translation available.
RefSeqiNP_055633.1, NM_014818.1 [O15016-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6IETX-ray2.10A968-1160[»]
6IEUX-ray1.79A968-1160[»]
SMRiO15016
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115199, 200 interactors
IntActiO15016, 2 interactors
STRINGi9606.ENSP00000384876

PTM databases

iPTMnetiO15016
PhosphoSitePlusiO15016

Genetic variation databases

BioMutaiTRIM66

Proteomic databases

jPOSTiO15016
MassIVEiO15016
PaxDbiO15016
PeptideAtlasiO15016
PRIDEiO15016
ProteomicsDBi48372 [O15016-1]
48373 [O15016-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		5888, 26 antibodies

The DNASU plasmid repository

More...DNASUi		9866

Genome annotation databases

EnsembliENST00000299550; ENSP00000299550; ENSG00000166436 [O15016-1]
GeneIDi9866
KEGGihsa:9866
UCSCiuc010rbo.2, human [O15016-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9866
DisGeNETi9866

GeneCards: human genes, protein and diseases

More...GeneCardsi		TRIM66
HGNCiHGNC:29005, TRIM66
HPAiENSG00000166436, Low tissue specificity
MIMi612000, gene
neXtProtiNX_O15016
OpenTargetsiENSG00000166436
PharmGKBiPA134954583
VEuPathDBiHostDB:ENSG00000166436.15

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2177, Eukaryota
GeneTreeiENSGT00940000159240
HOGENOMiCLU_005817_1_0_1
InParanoidiO15016
OrthoDBi756911at2759
PhylomeDBiO15016

Enzyme and pathway databases

PathwayCommonsiO15016

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9866, 1 hit in 203 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TRIM66, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9866
PharosiO15016, Tdark

Protein Ontology

More...PROi		PR:O15016
RNActiO15016, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000166436, Expressed in sural nerve and 192 other tissues
ExpressionAtlasiO15016, baseline and differential
GenevisibleiO15016, HS

Family and domain databases

Gene3Di1.20.920.10, 1 hit
InterProiView protein in InterPro
IPR003649, Bbox_C
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR037372, Trim66
IPR019786, Zinc_finger_PHD-type_CS
IPR000315, Znf_B-box
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
PANTHERiPTHR45915:SF7, PTHR45915:SF7, 1 hit
PfamiView protein in Pfam
PF00439, Bromodomain, 1 hit
PF00628, PHD, 1 hit
PF00643, zf-B_box, 1 hit
SMARTiView protein in SMART
SM00502, BBC, 1 hit
SM00336, BBOX, 2 hits
SM00297, BROMO, 1 hit
SM00249, PHD, 2 hits
SUPFAMiSSF47370, SSF47370, 1 hit
SSF57903, SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50014, BROMODOMAIN_2, 1 hit
PS50119, ZF_BBOX, 2 hits
PS01359, ZF_PHD_1, 1 hit
PS50016, ZF_PHD_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRI66_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15016
Secondary accession number(s): Q9BQQ4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 24, 2009
Last modified: June 2, 2021
This is version 157 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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