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Protein

Tripartite motif-containing protein 66

Gene

TRIM66

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May function as transcription repressor; The repressive effects are mediated, at least in part, by recruitment of deacetylase activity. May play a role as negative regulator of postmeiotic genes acting through CBX3 complex formation and centromere association (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 46B box-type 1; atypicalPROSITE-ProRule annotationAdd BLAST46
Zinc fingeri60 – 101B box-type 2PROSITE-ProRule annotationAdd BLAST42
Zinc fingeri970 – 1017PHD-typePROSITE-ProRule annotationAdd BLAST48

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 66
Gene namesi
Name:TRIM66
Synonyms:C11orf29, KIAA0298
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000166436.15
HGNCiHGNC:29005 TRIM66
MIMi612000 gene
neXtProtiNX_O15016

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9866
OpenTargetsiENSG00000166436
PharmGKBiPA134954583

Polymorphism and mutation databases

BioMutaiTRIM66

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002203751 – 1216Tripartite motif-containing protein 66Add BLAST1216

Proteomic databases

PaxDbiO15016
PeptideAtlasiO15016
PRIDEiO15016
ProteomicsDBi48372
48373 [O15016-2]

PTM databases

iPTMnetiO15016
PhosphoSitePlusiO15016

Expressioni

Gene expression databases

BgeeiENSG00000166436
CleanExiHS_TRIM66
ExpressionAtlasiO15016 baseline and differential
GenevisibleiO15016 HS

Organism-specific databases

HPAiHPA027420

Interactioni

Subunit structurei

Can form homodimers and heterodimers. Interacts with CBX5, CBX1 and CBX3 via PxVxL motif (By similarity).By similarity

Protein-protein interaction databases

IntActiO15016, 2 interactors
STRINGi9606.ENSP00000384876

Structurei

3D structure databases

ProteinModelPortaliO15016
SMRiO15016
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1056 – 1128BromoPROSITE-ProRule annotationAdd BLAST73

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili130 – 200Sequence analysisAdd BLAST71

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi860 – 864PxVxL motif5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi384 – 571Gln-richAdd BLAST188
Compositional biasi453 – 499Pro-richAdd BLAST47

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 46B box-type 1; atypicalPROSITE-ProRule annotationAdd BLAST46
Zinc fingeri60 – 101B box-type 2PROSITE-ProRule annotationAdd BLAST42
Zinc fingeri970 – 1017PHD-typePROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Bromodomain, Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2177 Eukaryota
ENOG41106NJ LUCA
GeneTreeiENSGT00920000148978
HOGENOMiHOG000074104
HOVERGENiHBG057849
InParanoidiO15016
KOiK12032
PhylomeDBiO15016

Family and domain databases

CDDicd00021 BBOX, 1 hit
Gene3Di1.20.920.10, 1 hit
InterProiView protein in InterPro
IPR003649 Bbox_C
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR037372 Trim66
IPR019786 Zinc_finger_PHD-type_CS
IPR000315 Znf_B-box
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
PANTHERiPTHR45154 PTHR45154, 2 hits
PfamiView protein in Pfam
PF00439 Bromodomain, 1 hit
PF00628 PHD, 1 hit
PF00643 zf-B_box, 1 hit
SMARTiView protein in SMART
SM00502 BBC, 1 hit
SM00336 BBOX, 2 hits
SM00297 BROMO, 1 hit
SM00249 PHD, 2 hits
SUPFAMiSSF47370 SSF47370, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50014 BROMODOMAIN_2, 1 hit
PS50119 ZF_BBOX, 2 hits
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O15016-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARNCSECKE KRAAHILCTY CNRWLCSSCT EEHRHSPVPG GPFFPRAQKG
60 70 80 90 100
SPGVNGGPGD FTLYCPLHTQ EVLKLFCETC DMLTCHSCLV VEHKEHRCRH
110 120 130 140 150
VEEVLQNQRM LLEGVTTQVA HKKSSLQTSA KQIEDRIFEV KHQHRKVENQ
160 170 180 190 200
IKMAKMVLMN ELNKQANGLI EELEGITNER KRKLEQQLQS IMVLNRQFEH
210 220 230 240 250
VQNFINWAVC SKTSVPFLFS KELIVFQMQR LLETSCNTDP GSPWSIRFTW
260 270 280 290 300
EPNFWTKQLA SLGCITTEGG QMSRADAPAY GGLQGSSPFY QSHQSPVAQQ
310 320 330 340 350
EALSHPSHKF QSPAVCSSSV CCSHCSPVSP SLKGQVPPPS IHPAHSFRQP
360 370 380 390 400
PEMVPQQLGS LQCSALLPRE KELACSPHPP KLLQPWLETQ PPVEQESTSQ
410 420 430 440 450
RLGQQLTSQP VCIVPPQDVQ QGAHAQPTLQ TPSIQVQFGH HQKLKLSHFQ
460 470 480 490 500
QQPQQQLPPP PPPLPHPPPP LPPPPQQPHP PLPPSQHLAS SQHESPPGPA
510 520 530 540 550
CSQNMDIMHH KFELEEMQKD LELLLQAQQP SLQLSQTKSP QHLQQTIVGQ
560 570 580 590 600
INYIVRQPAP VQSQSQEETL QATDEPPASQ GSKPALPLDK NTAAALPQAS
610 620 630 640 650
GEETPLSVPP VDSTIQHSSP NVVRKHSTSL SIMGFSNTLE MELSSTRLER
660 670 680 690 700
PLEPQIQSVS NLTAGAPQAV PSLLSAPPKM VSSLTSVQNQ AMPSLTTSHL
710 720 730 740 750
QTVPSLVHST FQSMPNLISD SPQAMASLAS DHPQAGPSLM SGHTQAVPSL
760 770 780 790 800
ATCPLQSIPP VSDMQPETGS SSSSGRTSGS LCPRDGADPS LENALCKVKL
810 820 830 840 850
EEPINLSVKK PPLAPVVSTS TALQQYQNPK ECENFEQGAL ELDAKENQSI
860 870 880 890 900
RAFNSEHKIP YVRLERLKIC AASSGEMPVF KLKPQKNDQD GSFLLIIECG
910 920 930 940 950
TESSSMSIKV SQDRLSEATQ APGLEGRKVT VTSLAGQRPP EVEGTSPEEH
960 970 980 990 1000
RLIPRTPGAK KGPPAPIENE DFCAVCLNGG ELLCCDRCPK VFHLSCHVPA
1010 1020 1030 1040 1050
LLSFPGGEWV CTLCRSLTQP EMEYDCENAC YNQPGMRASP GLSMYDQKKC
1060 1070 1080 1090 1100
EKLVLSLCCN NLSLPFHEPV SPLARHYYQI IKRPMDLSII RRKLQKKDPA
1110 1120 1130 1140 1150
HYTTPEEVVS DVRLMFWNCA KFNYPDSEVA EAGRCLEVFF EGWLKEIYPE
1160 1170 1180 1190 1200
KRFAQPRQED SDSEEVSSES GCSTPQGFPW PPYMQEGIQP KRRRRHMENE
1210
RAKRMSFRLA NSISQV
Length:1,216
Mass (Da):134,663
Last modified:November 24, 2009 - v4
Checksum:i5E0F4953230617D1
GO
Isoform 2 (identifier: O15016-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     97-98: Missing.

Show »
Length:1,214
Mass (Da):134,404
Checksum:iA3973C0EA2D47C3A
GO

Sequence cautioni

The sequence BAA20758 differs from that shown. Reason: Frameshift at position 797.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03838697 – 98Missing in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ400879 Genomic DNA Translation: CAC35389.1
AB002296 mRNA Translation: BAA20758.2 Frameshift.
AC091053 Genomic DNA No translation available.
AC104360 Genomic DNA No translation available.
RefSeqiNP_055633.1, NM_014818.1 [O15016-1]
UniGeneiHs.130836
Hs.716965

Genome annotation databases

EnsembliENST00000299550; ENSP00000299550; ENSG00000166436 [O15016-1]
GeneIDi9866
KEGGihsa:9866
UCSCiuc010rbo.2 human [O15016-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTRI66_HUMAN
AccessioniPrimary (citable) accession number: O15016
Secondary accession number(s): Q9BQQ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 24, 2009
Last modified: June 20, 2018
This is version 138 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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