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Protein

Zinc finger protein 609

Gene

ZNF609

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others.By similarity
Isoform 2: Involved in the regulation of myoblast proliferation during myogenesis.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri495 – 520C2H2-typePROSITE-ProRule annotationAdd BLAST26

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein
Biological processMyogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 609Imported
Gene namesi
Name:ZNF609Imported
Synonyms:KIAA02951 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000180357.9
HGNCiHGNC:29003 ZNF609
MIMi617474 gene
neXtProtiNX_O15014

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000180357
PharmGKBiPA134952302

Polymorphism and mutation databases

BioMutaiZNF609

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002804221 – 1411Zinc finger protein 609Add BLAST1411

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei358PhosphoserineCombined sources1
Modified residuei361PhosphoserineBy similarity1
Modified residuei379PhosphoserineCombined sources1
Modified residuei381PhosphothreonineCombined sources1
Modified residuei413PhosphoserineCombined sources1
Modified residuei433PhosphoserineCombined sources1
Modified residuei446PhosphoserineCombined sources1
Modified residuei452PhosphoserineCombined sources1
Modified residuei467PhosphoserineCombined sources1
Modified residuei470PhosphoserineCombined sources1
Cross-linki479Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei533PhosphoserineBy similarity1
Modified residuei576PhosphoserineCombined sources1
Modified residuei578PhosphoserineCombined sources1
Modified residuei743PhosphoserineCombined sources1
Modified residuei746PhosphothreonineCombined sources1
Modified residuei758PhosphoserineCombined sources1
Cross-linki789Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei804PhosphoserineCombined sources1
Modified residuei823PhosphothreonineCombined sources1
Modified residuei842PhosphoserineCombined sources1
Modified residuei846PhosphoserineCombined sources1
Modified residuei849PhosphoserineCombined sources1
Modified residuei1055PhosphoserineCombined sources1
Cross-linki1061Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1153Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1297Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO15014
MaxQBiO15014
PaxDbiO15014
PeptideAtlasiO15014
PRIDEiO15014
ProteomicsDBi48369

PTM databases

iPTMnetiO15014
PhosphoSitePlusiO15014

Expressioni

Tissue specificityi

Isoform 1: Expressed in myoblasts and myotubes. Isoform 2: Expressed in myoblasts and myotubes, with a preference in undifferentiated myoblasts.1 Publication

Inductioni

Isoform 1: Up-regulated during neuronal differentiation in retinoic acid-treated SH-SY5Y cells (PubMed:25921068). Isoform 2: Down-regulated during myogenesis (PubMed:28344082).2 Publications

Gene expression databases

BgeeiENSG00000180357
CleanExiHS_ZNF609
ExpressionAtlasiO15014 baseline and differential
GenevisibleiO15014 HS

Organism-specific databases

HPAiHPA040742
HPA040832

Interactioni

Subunit structurei

Interacts (via N-terminus) with NIPBL. Interacts with the multiprotein complex Integrator.By similarity

Protein-protein interaction databases

BioGridi116695, 28 interactors
DIPiDIP-50012N
IntActiO15014, 12 interactors

Structurei

3D structure databases

ProteinModelPortaliO15014
SMRiO15014
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi725 – 735Poly-LysAdd BLAST11
Compositional biasi952 – 955Poly-Ser4
Compositional biasi1333 – 1336Poly-Gly4
Compositional biasi1366 – 1371Poly-His6

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri495 – 520C2H2-typePROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IQYG Eukaryota
ENOG410XRNB LUCA
GeneTreeiENSGT00390000008748
HOGENOMiHOG000082539
HOVERGENiHBG054557
InParanoidiO15014
OMAiLMSTHHH
OrthoDBiEOG091G00Q9
PhylomeDBiO15014
TreeFamiTF329775

Family and domain databases

InterProiView protein in InterPro
IPR013087 Znf_C2H2_type
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O15014-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLSSGASGG KGVDANPVET YDSGDEWDIG VGNLIIDLDA DLEKDQQKLE
60 70 80 90 100
MSGSKEVGIP APNAVATLPD NIKFVTPVPG PQGKEGKSKS KRSKSGKDTS
110 120 130 140 150
KPTPGTSLFT PSEGAASKKE VQGRSGDGAN AGGLVAAIAP KGSEKAAKAS
160 170 180 190 200
RSVAGSKKEK ENSSSKSKKE RSEGVGTCSE KDPGVLQPVP LGGRGGQYDG
210 220 230 240 250
SAGVDTGAVE PLGSIAIEPG AALNPLGTKP EPEEGENECR LLKKVKSEKM
260 270 280 290 300
ESPVSTPAVL PIHLLVPVVN NDISSPCEQI MVRTRSVGVN TCDVALATEP
310 320 330 340 350
ECLGPCEPGT SVNLEGIVWQ ETEDGMLVVN VTWRNKTYVG TLLDCTRHDW
360 370 380 390 400
APPRFCDSPT SDLEMRNGRG RGKRMRPNSN TPVNETATAS DSKGTSNSSK
410 420 430 440 450
TRAGANSKGR RGSQNSSEHR PPASSTSEDV KASPSSANKR KNKPLSDMEL
460 470 480 490 500
NSSSEDSKGS KRVRTNSMGS ATGPLPGTKV EPTVLDRNCP SPVLIDCPHP
510 520 530 540 550
NCNKKYKHIN GLKYHQAHAH TDDDSKPEAD GDSEYGEEPI LHADLGSCNG
560 570 580 590 600
ASVSQKGSLS PARSATPKVR LVEPHSPSPS SKFSTKGLCK KKLSGEGDTD
610 620 630 640 650
LGALSNDGSD DGPSVMDETS NDAFDSLERK CMEKEKCKKP SSLKPEKIPS
660 670 680 690 700
KSLKSARPIA PAIPPQQIYT FQTATFTAAS PGSSSGLTAT VAQAMPNSPQ
710 720 730 740 750
LKPIQPKPTV MGEPFTVNPA LTPAKDKKKK DKKKKESSKE LESPLTPGKV
760 770 780 790 800
CRAEEGKSPF RESSGDGMKM EGLLNGSSDP HQSRLASIKA EADKIYSFTD
810 820 830 840 850
NAPSPSIGGS SRLENTTPTQ PLTPLHVVTQ NGAEASSVKT NSPAYSDISD
860 870 880 890 900
AGEDGEGKVD SVKSKDAEQL VKEGAKKTLF PPQPQSKDSP YYQGFESYYS
910 920 930 940 950
PSYAQSSPGA LNPSSQAGVE SQALKTKRDE EPESIEGKVK NDICEEKKPE
960 970 980 990 1000
LSSSSQQPSV IQQRPNMYMQ SLYYNQYAYV PPYGYSDQSY HTHLLSTNTA
1010 1020 1030 1040 1050
YRQQYEEQQK RQSLEQQQRG VDKKAEMGLK EREAALKEEW KQKPSIPPTL
1060 1070 1080 1090 1100
TKAPSLTDLV KSGPGKAKEP GADPAKSVII PKLDDSSKLP GQAPEGLKVK
1110 1120 1130 1140 1150
LSDASHLSKE ASEAKTGAEC GRQAEMDPIL WYRQEAEPRM WTYVYPAKYS
1160 1170 1180 1190 1200
DIKSEDERWK EERDRKLKEE RSRSKDSVPK EDGKESTSSD CKLPTSEESR
1210 1220 1230 1240 1250
LGSKEPRPSV HVPVSSPLTQ HQSYIPYMHG YSYSQSYDPN HPSYRSMPAV
1260 1270 1280 1290 1300
MMQNYPGSYL PSSYSFSPYG SKVSGGEDAD KARASPSVTC KSSSESKALD
1310 1320 1330 1340 1350
ILQQHASHYK SKSPTISDKT SQERDRGGCG VVGGGGSCSS VGGASGGERS
1360 1370 1380 1390 1400
VDRPRTSPSQ RLMSTHHHHH HLGYSLLPAQ YNLPYAAGLS STAIVASQQG
1410
STPSLYPPPR R
Length:1,411
Mass (Da):151,191
Last modified:March 20, 2007 - v2
Checksum:i63A32348BB5C678E
GO
Isoform 2 (identifier: O15014-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     250-250: M → Q
     251-1411: Missing.

Note: Produced by a back-splicing reaction which joins the 5'-splice site of the first coding exon with the 3'-splice site of the upstream intron resulting in a circular RNA, called circ-ZNF609. The translation starts with the same initiator methionine as that of the linear transcript encoding isoform 1. The stop codon is created upon circularization.1 Publication
Show »
Length:250
Mass (Da):25,397
Checksum:i9E2EC4A55EBCA544
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti766D → N in BAA20755 (PubMed:9205841).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_059082250M → Q in isoform 2. 1
Alternative sequenceiVSP_059083251 – 1411Missing in isoform 2. Add BLAST1161

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC090543 Genomic DNA No translation available.
AB002293 mRNA Translation: BAA20755.1
BC110401 mRNA Translation: AAI10402.1
CCDSiCCDS32270.1 [O15014-1]
RefSeqiNP_055857.1, NM_015042.1 [O15014-1]
XP_011519688.1, XM_011521386.2 [O15014-1]
XP_016877510.1, XM_017022021.1 [O15014-1]
UniGeneiHs.595451
Hs.696256

Genome annotation databases

EnsembliENST00000326648; ENSP00000316527; ENSG00000180357 [O15014-1]
GeneIDi23060
KEGGihsa:23060
UCSCiuc002ann.4 human [O15014-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZN609_HUMAN
AccessioniPrimary (citable) accession number: O15014
Secondary accession number(s): Q0D2I2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: July 18, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

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