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UniProtKB - O15014 (ZN609_HUMAN)

Entry version 150 (29 Sep 2021)
Sequence version 2 (20 Mar 2007)
Previous versions | rss
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Protein

Zinc finger protein 609

Gene

ZNF609

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others.

By similarity

Involved in the regulation of myoblast proliferation during myogenesis.

1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri495 – 520C2H2-typePROSITE-ProRule annotationAdd BLAST26

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein
Biological processMyogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O15014

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 609Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF609Imported
Synonyms:KIAA02951 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:29003, ZNF609

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		617474, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O15014

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000180357

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		23060

Open Targets

More...OpenTargetsi		ENSG00000180357

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134952302

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O15014, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF609

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002804221 – 1411Zinc finger protein 609Add BLAST1411

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei358PhosphoserineCombined sources1
Modified residuei361PhosphoserineBy similarity1
Modified residuei379PhosphoserineCombined sources1
Modified residuei381PhosphothreonineCombined sources1
Modified residuei413PhosphoserineCombined sources1
Modified residuei433PhosphoserineCombined sources1
Modified residuei446PhosphoserineCombined sources1
Modified residuei452PhosphoserineCombined sources1
Modified residuei467PhosphoserineCombined sources1
Modified residuei470PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki479Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei533PhosphoserineBy similarity1
Modified residuei576PhosphoserineCombined sources1
Modified residuei578PhosphoserineCombined sources1
Modified residuei743PhosphoserineCombined sources1
Modified residuei746PhosphothreonineCombined sources1
Modified residuei758PhosphoserineCombined sources1
Cross-linki789Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei804PhosphoserineCombined sources1
Modified residuei823PhosphothreonineCombined sources1
Modified residuei842PhosphoserineCombined sources1
Modified residuei846PhosphoserineCombined sources1
Modified residuei849PhosphoserineCombined sources1
Modified residuei1055PhosphoserineCombined sources1
Cross-linki1061Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1153Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1297Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O15014

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O15014

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O15014

MaxQB - The MaxQuant DataBase

More...MaxQBi		O15014

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O15014

PeptideAtlas

More...PeptideAtlasi		O15014

PRoteomics IDEntifications database

More...PRIDEi		O15014

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		48369

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O15014, 2 sites, 1 O-linked glycan (2 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O15014

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O15014

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1: Expressed in myoblasts and myotubes. Isoform 2: Expressed in myoblasts and myotubes, with a preference in undifferentiated myoblasts.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Isoform 1: Up-regulated during neuronal differentiation in retinoic acid-treated SH-SY5Y cells (PubMed:25921068). Isoform 2: Down-regulated during myogenesis (PubMed:28344082).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000180357, Expressed in ventricular zone and 202 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O15014, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O15014, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000180357, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via N-terminus) with NIPBL.

Interacts with the multiprotein complex Integrator.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116695, 57 interactors

Database of interacting proteins

More...DIPi		DIP-50012N

Protein interaction database and analysis system

More...IntActi		O15014, 21 interactors

Molecular INTeraction database

More...MINTi		O15014

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000316527

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O15014, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O15014

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 26DisorderedSequence analysisAdd BLAST26
Regioni47 – 190DisorderedSequence analysisAdd BLAST144
Regioni353 – 484DisorderedSequence analysisAdd BLAST132
Regioni517 – 659DisorderedSequence analysisAdd BLAST143
Regioni679 – 963DisorderedSequence analysisAdd BLAST285
Regioni1005 – 1125DisorderedSequence analysisAdd BLAST121
Regioni1153 – 1221DisorderedSequence analysisAdd BLAST69
Regioni1270 – 1367DisorderedSequence analysisAdd BLAST98

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi99 – 113Polar residuesSequence analysisAdd BLAST15
Compositional biasi151 – 177Basic and acidic residuesSequence analysisAdd BLAST27
Compositional biasi377 – 453Polar residuesSequence analysisAdd BLAST77
Compositional biasi517 – 539Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi548 – 562Polar residuesSequence analysisAdd BLAST15
Compositional biasi622 – 645Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi679 – 700Polar residuesSequence analysisAdd BLAST22
Compositional biasi799 – 847Polar residuesSequence analysisAdd BLAST49
Compositional biasi851 – 873Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi882 – 922Polar residuesSequence analysisAdd BLAST41
Compositional biasi923 – 949Basic and acidic residuesSequence analysisAdd BLAST27
Compositional biasi1008 – 1040Basic and acidic residuesSequence analysisAdd BLAST33
Compositional biasi1102 – 1116Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1153 – 1188Basic and acidic residuesSequence analysisAdd BLAST36
Compositional biasi1286 – 1316Polar residuesSequence analysisAdd BLAST31

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri495 – 520C2H2-typePROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RCUP, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000008748

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004142_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O15014

Identification of Orthologs from Complete Genome Data

More...OMAi		DGMDDRK

Database of Orthologous Groups

More...OrthoDBi		60503at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O15014

TreeFam database of animal gene trees

More...TreeFami		TF329775

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR040010, ZN608/ZN609
IPR013087, Znf_C2H2_type

The PANTHER Classification System

More...PANTHERi		PTHR21564, PTHR21564, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 1 hit
PS50157, ZINC_FINGER_C2H2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O15014-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLSSGASGG KGVDANPVET YDSGDEWDIG VGNLIIDLDA DLEKDQQKLE 
        60         70         80         90        100
MSGSKEVGIP APNAVATLPD NIKFVTPVPG PQGKEGKSKS KRSKSGKDTS 
       110        120        130        140        150
KPTPGTSLFT PSEGAASKKE VQGRSGDGAN AGGLVAAIAP KGSEKAAKAS 
       160        170        180        190        200
RSVAGSKKEK ENSSSKSKKE RSEGVGTCSE KDPGVLQPVP LGGRGGQYDG 
       210        220        230        240        250
SAGVDTGAVE PLGSIAIEPG AALNPLGTKP EPEEGENECR LLKKVKSEKM 
       260        270        280        290        300
ESPVSTPAVL PIHLLVPVVN NDISSPCEQI MVRTRSVGVN TCDVALATEP 
       310        320        330        340        350
ECLGPCEPGT SVNLEGIVWQ ETEDGMLVVN VTWRNKTYVG TLLDCTRHDW 
       360        370        380        390        400
APPRFCDSPT SDLEMRNGRG RGKRMRPNSN TPVNETATAS DSKGTSNSSK 
       410        420        430        440        450
TRAGANSKGR RGSQNSSEHR PPASSTSEDV KASPSSANKR KNKPLSDMEL 
       460        470        480        490        500
NSSSEDSKGS KRVRTNSMGS ATGPLPGTKV EPTVLDRNCP SPVLIDCPHP 
       510        520        530        540        550
NCNKKYKHIN GLKYHQAHAH TDDDSKPEAD GDSEYGEEPI LHADLGSCNG 
       560        570        580        590        600
ASVSQKGSLS PARSATPKVR LVEPHSPSPS SKFSTKGLCK KKLSGEGDTD 
       610        620        630        640        650
LGALSNDGSD DGPSVMDETS NDAFDSLERK CMEKEKCKKP SSLKPEKIPS 
       660        670        680        690        700
KSLKSARPIA PAIPPQQIYT FQTATFTAAS PGSSSGLTAT VAQAMPNSPQ 
       710        720        730        740        750
LKPIQPKPTV MGEPFTVNPA LTPAKDKKKK DKKKKESSKE LESPLTPGKV 
       760        770        780        790        800
CRAEEGKSPF RESSGDGMKM EGLLNGSSDP HQSRLASIKA EADKIYSFTD 
       810        820        830        840        850
NAPSPSIGGS SRLENTTPTQ PLTPLHVVTQ NGAEASSVKT NSPAYSDISD 
       860        870        880        890        900
AGEDGEGKVD SVKSKDAEQL VKEGAKKTLF PPQPQSKDSP YYQGFESYYS 
       910        920        930        940        950
PSYAQSSPGA LNPSSQAGVE SQALKTKRDE EPESIEGKVK NDICEEKKPE 
       960        970        980        990       1000
LSSSSQQPSV IQQRPNMYMQ SLYYNQYAYV PPYGYSDQSY HTHLLSTNTA 
      1010       1020       1030       1040       1050
YRQQYEEQQK RQSLEQQQRG VDKKAEMGLK EREAALKEEW KQKPSIPPTL 
      1060       1070       1080       1090       1100
TKAPSLTDLV KSGPGKAKEP GADPAKSVII PKLDDSSKLP GQAPEGLKVK 
      1110       1120       1130       1140       1150
LSDASHLSKE ASEAKTGAEC GRQAEMDPIL WYRQEAEPRM WTYVYPAKYS 
      1160       1170       1180       1190       1200
DIKSEDERWK EERDRKLKEE RSRSKDSVPK EDGKESTSSD CKLPTSEESR 
      1210       1220       1230       1240       1250
LGSKEPRPSV HVPVSSPLTQ HQSYIPYMHG YSYSQSYDPN HPSYRSMPAV 
      1260       1270       1280       1290       1300
MMQNYPGSYL PSSYSFSPYG SKVSGGEDAD KARASPSVTC KSSSESKALD 
      1310       1320       1330       1340       1350
ILQQHASHYK SKSPTISDKT SQERDRGGCG VVGGGGSCSS VGGASGGERS 
      1360       1370       1380       1390       1400
VDRPRTSPSQ RLMSTHHHHH HLGYSLLPAQ YNLPYAAGLS STAIVASQQG 
      1410 
STPSLYPPPR R
Length:1,411
Mass (Da):151,191
Last modified:March 20, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i63A32348BB5C678E
GO
Isoform 2 (identifier: O15014-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     250-250: M → Q
     251-1411: Missing.

Note: Produced by a back-splicing reaction which joins the 5'-splice site of the first coding exon with the 3'-splice site of the upstream intron resulting in a circular RNA, called circ-ZNF609. The translation starts with the same initiator methionine as that of the linear transcript encoding isoform 1. The stop codon is created upon circularization.1 Publication
Show »
Length:250
Mass (Da):25,397
Checksum:i9E2EC4A55EBCA544
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ERY8E7ERY8_HUMAN
Zinc finger protein 609
ZNF609
331Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti766D → N in BAA20755 (PubMed:9205841).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_059082250M → Q in isoform 2. 1
Alternative sequenceiVSP_059083251 – 1411Missing in isoform 2. Add BLAST1161

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC090543 Genomic DNA No translation available.
AB002293 mRNA Translation: BAA20755.1
BC110401 mRNA Translation: AAI10402.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32270.1 [O15014-1]

NCBI Reference Sequences

More...RefSeqi		NP_055857.1, NM_015042.1 [O15014-1]
XP_011519688.1, XM_011521386.2
XP_016877510.1, XM_017022021.1 [O15014-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000326648; ENSP00000316527; ENSG00000180357 [O15014-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23060

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23060

UCSC genome browser

More...UCSCi		uc002ann.4, human [O15014-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Protein Spotlight

Round in circles - Issue 199 of January 2018

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC090543 Genomic DNA No translation available.
AB002293 mRNA Translation: BAA20755.1
BC110401 mRNA Translation: AAI10402.1
CCDSiCCDS32270.1 [O15014-1]
RefSeqiNP_055857.1, NM_015042.1 [O15014-1]
XP_011519688.1, XM_011521386.2
XP_016877510.1, XM_017022021.1 [O15014-1]

3D structure databases

SMRiO15014
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116695, 57 interactors
DIPiDIP-50012N
IntActiO15014, 21 interactors
MINTiO15014
STRINGi9606.ENSP00000316527

PTM databases

GlyGeniO15014, 2 sites, 1 O-linked glycan (2 sites)
iPTMnetiO15014
PhosphoSitePlusiO15014

Genetic variation databases

BioMutaiZNF609

Proteomic databases

EPDiO15014
jPOSTiO15014
MassIVEiO15014
MaxQBiO15014
PaxDbiO15014
PeptideAtlasiO15014
PRIDEiO15014
ProteomicsDBi48369

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		25830, 36 antibodies

The DNASU plasmid repository

More...DNASUi		23060

Genome annotation databases

EnsembliENST00000326648; ENSP00000316527; ENSG00000180357 [O15014-1]
GeneIDi23060
KEGGihsa:23060
UCSCiuc002ann.4, human [O15014-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23060
DisGeNETi23060

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF609
HGNCiHGNC:29003, ZNF609
HPAiENSG00000180357, Low tissue specificity
MIMi617474, gene
neXtProtiNX_O15014
OpenTargetsiENSG00000180357
PharmGKBiPA134952302
VEuPathDBiHostDB:ENSG00000180357

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502RCUP, Eukaryota
GeneTreeiENSGT00390000008748
HOGENOMiCLU_004142_0_0_1
InParanoidiO15014
OMAiDGMDDRK
OrthoDBi60503at2759
PhylomeDBiO15014
TreeFamiTF329775

Enzyme and pathway databases

PathwayCommonsiO15014

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		23060, 12 hits in 1018 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZNF609, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23060
PharosiO15014, Tdark

Protein Ontology

More...PROi		PR:O15014
RNActiO15014, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000180357, Expressed in ventricular zone and 202 other tissues
ExpressionAtlasiO15014, baseline and differential
GenevisibleiO15014, HS

Family and domain databases

InterProiView protein in InterPro
IPR040010, ZN608/ZN609
IPR013087, Znf_C2H2_type
PANTHERiPTHR21564, PTHR21564, 1 hit
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 1 hit
PS50157, ZINC_FINGER_C2H2_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN609_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15014
Secondary accession number(s): Q0D2I2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: September 29, 2021
This is version 150 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
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