UniProtKB - O15014 (ZN609_HUMAN)
Protein
Zinc finger protein 609
Gene
ZNF609
Organism
Homo sapiens (Human)
Status
Functioni
Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others.By similarity
Isoform 2: Involved in the regulation of myoblast proliferation during myogenesis.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 495 – 520 | C2H2-typePROSITE-ProRule annotationAdd BLAST | 26 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- nucleic acid binding Source: InterPro
GO - Biological processi
- muscle organ development Source: UniProtKB-KW
- positive regulation of neuron migration Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- regulation of myoblast proliferation Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: UniProtKB
Keywordsi
Molecular function | Activator, Developmental protein |
Biological process | Myogenesis, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 609Imported |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000180357.9 |
HGNCi | HGNC:29003 ZNF609 |
MIMi | 617474 gene |
neXtProti | NX_O15014 |
Subcellular locationi
Nucleus
- integrator complex Source: UniProtKB
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000180357 |
PharmGKBi | PA134952302 |
Polymorphism and mutation databases
BioMutai | ZNF609 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000280422 | 1 – 1411 | Zinc finger protein 609Add BLAST | 1411 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 358 | PhosphoserineCombined sources | 1 | |
Modified residuei | 361 | PhosphoserineBy similarity | 1 | |
Modified residuei | 379 | PhosphoserineCombined sources | 1 | |
Modified residuei | 381 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 413 | PhosphoserineCombined sources | 1 | |
Modified residuei | 433 | PhosphoserineCombined sources | 1 | |
Modified residuei | 446 | PhosphoserineCombined sources | 1 | |
Modified residuei | 452 | PhosphoserineCombined sources | 1 | |
Modified residuei | 467 | PhosphoserineCombined sources | 1 | |
Modified residuei | 470 | PhosphoserineCombined sources | 1 | |
Cross-linki | 479 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 533 | PhosphoserineBy similarity | 1 | |
Modified residuei | 576 | PhosphoserineCombined sources | 1 | |
Modified residuei | 578 | PhosphoserineCombined sources | 1 | |
Modified residuei | 743 | PhosphoserineCombined sources | 1 | |
Modified residuei | 746 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 758 | PhosphoserineCombined sources | 1 | |
Cross-linki | 789 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 804 | PhosphoserineCombined sources | 1 | |
Modified residuei | 823 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 842 | PhosphoserineCombined sources | 1 | |
Modified residuei | 846 | PhosphoserineCombined sources | 1 | |
Modified residuei | 849 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1055 | PhosphoserineCombined sources | 1 | |
Cross-linki | 1061 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1153 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 1297 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | O15014 |
jPOSTi | O15014 |
MaxQBi | O15014 |
PaxDbi | O15014 |
PeptideAtlasi | O15014 |
PRIDEi | O15014 |
ProteomicsDBi | 48369 |
PTM databases
iPTMneti | O15014 |
PhosphoSitePlusi | O15014 |
Expressioni
Tissue specificityi
Isoform 1: Expressed in myoblasts and myotubes. Isoform 2: Expressed in myoblasts and myotubes, with a preference in undifferentiated myoblasts.1 Publication
Inductioni
Isoform 1: Up-regulated during neuronal differentiation in retinoic acid-treated SH-SY5Y cells (PubMed:25921068). Isoform 2: Down-regulated during myogenesis (PubMed:28344082).2 Publications
Gene expression databases
Bgeei | ENSG00000180357 Expressed in 186 organ(s), highest expression level in testis |
ExpressionAtlasi | O15014 baseline and differential |
Genevisiblei | O15014 HS |
Organism-specific databases
HPAi | HPA040742 HPA040832 |
Interactioni
Subunit structurei
Interacts (via N-terminus) with NIPBL. Interacts with the multiprotein complex Integrator.By similarity
Protein-protein interaction databases
BioGridi | 116695, 30 interactors |
DIPi | DIP-50012N |
IntActi | O15014, 13 interactors |
Structurei
3D structure databases
ProteinModelPortali | O15014 |
SMRi | O15014 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 725 – 735 | Poly-LysAdd BLAST | 11 | |
Compositional biasi | 952 – 955 | Poly-Ser | 4 | |
Compositional biasi | 1333 – 1336 | Poly-Gly | 4 | |
Compositional biasi | 1366 – 1371 | Poly-His | 6 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 495 – 520 | C2H2-typePROSITE-ProRule annotationAdd BLAST | 26 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | ENOG410IQYG Eukaryota ENOG410XRNB LUCA |
GeneTreei | ENSGT00390000008748 |
HOGENOMi | HOG000082539 |
HOVERGENi | HBG054557 |
InParanoidi | O15014 |
OMAi | KVKNDVC |
OrthoDBi | 60503at2759 |
PhylomeDBi | O15014 |
TreeFami | TF329775 |
Family and domain databases
InterProi | View protein in InterPro IPR040010 ZN608/ZN609 IPR013087 Znf_C2H2_type |
PANTHERi | PTHR21564 PTHR21564, 1 hit |
PROSITEi | View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 1 hit PS50157 ZINC_FINGER_C2H2_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: O15014-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MSLSSGASGG KGVDANPVET YDSGDEWDIG VGNLIIDLDA DLEKDQQKLE
60 70 80 90 100
MSGSKEVGIP APNAVATLPD NIKFVTPVPG PQGKEGKSKS KRSKSGKDTS
110 120 130 140 150
KPTPGTSLFT PSEGAASKKE VQGRSGDGAN AGGLVAAIAP KGSEKAAKAS
160 170 180 190 200
RSVAGSKKEK ENSSSKSKKE RSEGVGTCSE KDPGVLQPVP LGGRGGQYDG
210 220 230 240 250
SAGVDTGAVE PLGSIAIEPG AALNPLGTKP EPEEGENECR LLKKVKSEKM
260 270 280 290 300
ESPVSTPAVL PIHLLVPVVN NDISSPCEQI MVRTRSVGVN TCDVALATEP
310 320 330 340 350
ECLGPCEPGT SVNLEGIVWQ ETEDGMLVVN VTWRNKTYVG TLLDCTRHDW
360 370 380 390 400
APPRFCDSPT SDLEMRNGRG RGKRMRPNSN TPVNETATAS DSKGTSNSSK
410 420 430 440 450
TRAGANSKGR RGSQNSSEHR PPASSTSEDV KASPSSANKR KNKPLSDMEL
460 470 480 490 500
NSSSEDSKGS KRVRTNSMGS ATGPLPGTKV EPTVLDRNCP SPVLIDCPHP
510 520 530 540 550
NCNKKYKHIN GLKYHQAHAH TDDDSKPEAD GDSEYGEEPI LHADLGSCNG
560 570 580 590 600
ASVSQKGSLS PARSATPKVR LVEPHSPSPS SKFSTKGLCK KKLSGEGDTD
610 620 630 640 650
LGALSNDGSD DGPSVMDETS NDAFDSLERK CMEKEKCKKP SSLKPEKIPS
660 670 680 690 700
KSLKSARPIA PAIPPQQIYT FQTATFTAAS PGSSSGLTAT VAQAMPNSPQ
710 720 730 740 750
LKPIQPKPTV MGEPFTVNPA LTPAKDKKKK DKKKKESSKE LESPLTPGKV
760 770 780 790 800
CRAEEGKSPF RESSGDGMKM EGLLNGSSDP HQSRLASIKA EADKIYSFTD
810 820 830 840 850
NAPSPSIGGS SRLENTTPTQ PLTPLHVVTQ NGAEASSVKT NSPAYSDISD
860 870 880 890 900
AGEDGEGKVD SVKSKDAEQL VKEGAKKTLF PPQPQSKDSP YYQGFESYYS
910 920 930 940 950
PSYAQSSPGA LNPSSQAGVE SQALKTKRDE EPESIEGKVK NDICEEKKPE
960 970 980 990 1000
LSSSSQQPSV IQQRPNMYMQ SLYYNQYAYV PPYGYSDQSY HTHLLSTNTA
1010 1020 1030 1040 1050
YRQQYEEQQK RQSLEQQQRG VDKKAEMGLK EREAALKEEW KQKPSIPPTL
1060 1070 1080 1090 1100
TKAPSLTDLV KSGPGKAKEP GADPAKSVII PKLDDSSKLP GQAPEGLKVK
1110 1120 1130 1140 1150
LSDASHLSKE ASEAKTGAEC GRQAEMDPIL WYRQEAEPRM WTYVYPAKYS
1160 1170 1180 1190 1200
DIKSEDERWK EERDRKLKEE RSRSKDSVPK EDGKESTSSD CKLPTSEESR
1210 1220 1230 1240 1250
LGSKEPRPSV HVPVSSPLTQ HQSYIPYMHG YSYSQSYDPN HPSYRSMPAV
1260 1270 1280 1290 1300
MMQNYPGSYL PSSYSFSPYG SKVSGGEDAD KARASPSVTC KSSSESKALD
1310 1320 1330 1340 1350
ILQQHASHYK SKSPTISDKT SQERDRGGCG VVGGGGSCSS VGGASGGERS
1360 1370 1380 1390 1400
VDRPRTSPSQ RLMSTHHHHH HLGYSLLPAQ YNLPYAAGLS STAIVASQQG
1410
STPSLYPPPR R
Isoform 2 (identifier: O15014-2) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
250-250: M → Q
251-1411: Missing.
Note: Produced by a back-splicing reaction which joins the 5'-splice site of the first coding exon with the 3'-splice site of the upstream intron resulting in a circular RNA, called circ-ZNF609. The translation starts with the same initiator methionine as that of the linear transcript encoding isoform 1. The stop codon is created upon circularization.1 Publication
Show »Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE7ERY8 | E7ERY8_HUMAN | Zinc finger protein 609 | ZNF609 | 331 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 766 | D → N in BAA20755 (PubMed:9205841).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_059082 | 250 | M → Q in isoform 2. | 1 | |
Alternative sequenceiVSP_059083 | 251 – 1411 | Missing in isoform 2. Add BLAST | 1161 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC090543 Genomic DNA No translation available. AB002293 mRNA Translation: BAA20755.1 BC110401 mRNA Translation: AAI10402.1 |
CCDSi | CCDS32270.1 [O15014-1] |
RefSeqi | NP_055857.1, NM_015042.1 [O15014-1] XP_011519688.1, XM_011521386.2 [O15014-1] XP_016877510.1, XM_017022021.1 [O15014-1] |
UniGenei | Hs.595451 Hs.696256 |
Genome annotation databases
Ensembli | ENST00000326648; ENSP00000316527; ENSG00000180357 [O15014-1] |
GeneIDi | 23060 |
KEGGi | hsa:23060 |
UCSCi | uc002ann.4 human [O15014-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Protein Spotlight Round in circles - Issue 199 of January 2018 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC090543 Genomic DNA No translation available. AB002293 mRNA Translation: BAA20755.1 BC110401 mRNA Translation: AAI10402.1 |
CCDSi | CCDS32270.1 [O15014-1] |
RefSeqi | NP_055857.1, NM_015042.1 [O15014-1] XP_011519688.1, XM_011521386.2 [O15014-1] XP_016877510.1, XM_017022021.1 [O15014-1] |
UniGenei | Hs.595451 Hs.696256 |
3D structure databases
ProteinModelPortali | O15014 |
SMRi | O15014 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 116695, 30 interactors |
DIPi | DIP-50012N |
IntActi | O15014, 13 interactors |
PTM databases
iPTMneti | O15014 |
PhosphoSitePlusi | O15014 |
Polymorphism and mutation databases
BioMutai | ZNF609 |
Proteomic databases
EPDi | O15014 |
jPOSTi | O15014 |
MaxQBi | O15014 |
PaxDbi | O15014 |
PeptideAtlasi | O15014 |
PRIDEi | O15014 |
ProteomicsDBi | 48369 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000326648; ENSP00000316527; ENSG00000180357 [O15014-1] |
GeneIDi | 23060 |
KEGGi | hsa:23060 |
UCSCi | uc002ann.4 human [O15014-1] |
Organism-specific databases
CTDi | 23060 |
EuPathDBi | HostDB:ENSG00000180357.9 |
GeneCardsi | ZNF609 |
HGNCi | HGNC:29003 ZNF609 |
HPAi | HPA040742 HPA040832 |
MIMi | 617474 gene |
neXtProti | NX_O15014 |
OpenTargetsi | ENSG00000180357 |
PharmGKBi | PA134952302 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410IQYG Eukaryota ENOG410XRNB LUCA |
GeneTreei | ENSGT00390000008748 |
HOGENOMi | HOG000082539 |
HOVERGENi | HBG054557 |
InParanoidi | O15014 |
OMAi | KVKNDVC |
OrthoDBi | 60503at2759 |
PhylomeDBi | O15014 |
TreeFami | TF329775 |
Miscellaneous databases
ChiTaRSi | ZNF609 human |
GenomeRNAii | 23060 |
PROi | PR:O15014 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000180357 Expressed in 186 organ(s), highest expression level in testis |
ExpressionAtlasi | O15014 baseline and differential |
Genevisiblei | O15014 HS |
Family and domain databases
InterProi | View protein in InterPro IPR040010 ZN608/ZN609 IPR013087 Znf_C2H2_type |
PANTHERi | PTHR21564 PTHR21564, 1 hit |
PROSITEi | View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 1 hit PS50157 ZINC_FINGER_C2H2_2, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | ZN609_HUMAN | |
Accessioni | O15014Primary (citable) accession number: O15014 Secondary accession number(s): Q0D2I2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 20, 2007 |
Last sequence update: | March 20, 2007 | |
Last modified: | February 13, 2019 | |
This is version 135 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries