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Entry version 135 (13 Feb 2019)
Sequence version 2 (20 Mar 2007)
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Protein

Zinc finger protein 609

Gene

ZNF609

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others.By similarity
Isoform 2: Involved in the regulation of myoblast proliferation during myogenesis.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri495 – 520C2H2-typePROSITE-ProRule annotationAdd BLAST26

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein
Biological processMyogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 609Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF609Imported
Synonyms:KIAA02951 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000180357.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29003 ZNF609

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617474 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O15014

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000180357

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134952302

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF609

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002804221 – 1411Zinc finger protein 609Add BLAST1411

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei358PhosphoserineCombined sources1
Modified residuei361PhosphoserineBy similarity1
Modified residuei379PhosphoserineCombined sources1
Modified residuei381PhosphothreonineCombined sources1
Modified residuei413PhosphoserineCombined sources1
Modified residuei433PhosphoserineCombined sources1
Modified residuei446PhosphoserineCombined sources1
Modified residuei452PhosphoserineCombined sources1
Modified residuei467PhosphoserineCombined sources1
Modified residuei470PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki479Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei533PhosphoserineBy similarity1
Modified residuei576PhosphoserineCombined sources1
Modified residuei578PhosphoserineCombined sources1
Modified residuei743PhosphoserineCombined sources1
Modified residuei746PhosphothreonineCombined sources1
Modified residuei758PhosphoserineCombined sources1
Cross-linki789Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei804PhosphoserineCombined sources1
Modified residuei823PhosphothreonineCombined sources1
Modified residuei842PhosphoserineCombined sources1
Modified residuei846PhosphoserineCombined sources1
Modified residuei849PhosphoserineCombined sources1
Modified residuei1055PhosphoserineCombined sources1
Cross-linki1061Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1153Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1297Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O15014

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O15014

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O15014

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O15014

PeptideAtlas

More...
PeptideAtlasi
O15014

PRoteomics IDEntifications database

More...
PRIDEi
O15014

ProteomicsDB human proteome resource

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ProteomicsDBi
48369

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O15014

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O15014

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1: Expressed in myoblasts and myotubes. Isoform 2: Expressed in myoblasts and myotubes, with a preference in undifferentiated myoblasts.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Isoform 1: Up-regulated during neuronal differentiation in retinoic acid-treated SH-SY5Y cells (PubMed:25921068). Isoform 2: Down-regulated during myogenesis (PubMed:28344082).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000180357 Expressed in 186 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O15014 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O15014 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA040742
HPA040832

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via N-terminus) with NIPBL. Interacts with the multiprotein complex Integrator.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116695, 30 interactors

Database of interacting proteins

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DIPi
DIP-50012N

Protein interaction database and analysis system

More...
IntActi
O15014, 13 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O15014

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O15014

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi725 – 735Poly-LysAdd BLAST11
Compositional biasi952 – 955Poly-Ser4
Compositional biasi1333 – 1336Poly-Gly4
Compositional biasi1366 – 1371Poly-His6

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri495 – 520C2H2-typePROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IQYG Eukaryota
ENOG410XRNB LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000008748

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000082539

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG054557

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O15014

Identification of Orthologs from Complete Genome Data

More...
OMAi
KVKNDVC

Database of Orthologous Groups

More...
OrthoDBi
60503at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O15014

TreeFam database of animal gene trees

More...
TreeFami
TF329775

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR040010 ZN608/ZN609
IPR013087 Znf_C2H2_type

The PANTHER Classification System

More...
PANTHERi
PTHR21564 PTHR21564, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O15014-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLSSGASGG KGVDANPVET YDSGDEWDIG VGNLIIDLDA DLEKDQQKLE
60 70 80 90 100
MSGSKEVGIP APNAVATLPD NIKFVTPVPG PQGKEGKSKS KRSKSGKDTS
110 120 130 140 150
KPTPGTSLFT PSEGAASKKE VQGRSGDGAN AGGLVAAIAP KGSEKAAKAS
160 170 180 190 200
RSVAGSKKEK ENSSSKSKKE RSEGVGTCSE KDPGVLQPVP LGGRGGQYDG
210 220 230 240 250
SAGVDTGAVE PLGSIAIEPG AALNPLGTKP EPEEGENECR LLKKVKSEKM
260 270 280 290 300
ESPVSTPAVL PIHLLVPVVN NDISSPCEQI MVRTRSVGVN TCDVALATEP
310 320 330 340 350
ECLGPCEPGT SVNLEGIVWQ ETEDGMLVVN VTWRNKTYVG TLLDCTRHDW
360 370 380 390 400
APPRFCDSPT SDLEMRNGRG RGKRMRPNSN TPVNETATAS DSKGTSNSSK
410 420 430 440 450
TRAGANSKGR RGSQNSSEHR PPASSTSEDV KASPSSANKR KNKPLSDMEL
460 470 480 490 500
NSSSEDSKGS KRVRTNSMGS ATGPLPGTKV EPTVLDRNCP SPVLIDCPHP
510 520 530 540 550
NCNKKYKHIN GLKYHQAHAH TDDDSKPEAD GDSEYGEEPI LHADLGSCNG
560 570 580 590 600
ASVSQKGSLS PARSATPKVR LVEPHSPSPS SKFSTKGLCK KKLSGEGDTD
610 620 630 640 650
LGALSNDGSD DGPSVMDETS NDAFDSLERK CMEKEKCKKP SSLKPEKIPS
660 670 680 690 700
KSLKSARPIA PAIPPQQIYT FQTATFTAAS PGSSSGLTAT VAQAMPNSPQ
710 720 730 740 750
LKPIQPKPTV MGEPFTVNPA LTPAKDKKKK DKKKKESSKE LESPLTPGKV
760 770 780 790 800
CRAEEGKSPF RESSGDGMKM EGLLNGSSDP HQSRLASIKA EADKIYSFTD
810 820 830 840 850
NAPSPSIGGS SRLENTTPTQ PLTPLHVVTQ NGAEASSVKT NSPAYSDISD
860 870 880 890 900
AGEDGEGKVD SVKSKDAEQL VKEGAKKTLF PPQPQSKDSP YYQGFESYYS
910 920 930 940 950
PSYAQSSPGA LNPSSQAGVE SQALKTKRDE EPESIEGKVK NDICEEKKPE
960 970 980 990 1000
LSSSSQQPSV IQQRPNMYMQ SLYYNQYAYV PPYGYSDQSY HTHLLSTNTA
1010 1020 1030 1040 1050
YRQQYEEQQK RQSLEQQQRG VDKKAEMGLK EREAALKEEW KQKPSIPPTL
1060 1070 1080 1090 1100
TKAPSLTDLV KSGPGKAKEP GADPAKSVII PKLDDSSKLP GQAPEGLKVK
1110 1120 1130 1140 1150
LSDASHLSKE ASEAKTGAEC GRQAEMDPIL WYRQEAEPRM WTYVYPAKYS
1160 1170 1180 1190 1200
DIKSEDERWK EERDRKLKEE RSRSKDSVPK EDGKESTSSD CKLPTSEESR
1210 1220 1230 1240 1250
LGSKEPRPSV HVPVSSPLTQ HQSYIPYMHG YSYSQSYDPN HPSYRSMPAV
1260 1270 1280 1290 1300
MMQNYPGSYL PSSYSFSPYG SKVSGGEDAD KARASPSVTC KSSSESKALD
1310 1320 1330 1340 1350
ILQQHASHYK SKSPTISDKT SQERDRGGCG VVGGGGSCSS VGGASGGERS
1360 1370 1380 1390 1400
VDRPRTSPSQ RLMSTHHHHH HLGYSLLPAQ YNLPYAAGLS STAIVASQQG
1410
STPSLYPPPR R
Length:1,411
Mass (Da):151,191
Last modified:March 20, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i63A32348BB5C678E
GO
Isoform 2 (identifier: O15014-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     250-250: M → Q
     251-1411: Missing.

Note: Produced by a back-splicing reaction which joins the 5'-splice site of the first coding exon with the 3'-splice site of the upstream intron resulting in a circular RNA, called circ-ZNF609. The translation starts with the same initiator methionine as that of the linear transcript encoding isoform 1. The stop codon is created upon circularization.1 Publication
Show »
Length:250
Mass (Da):25,397
Checksum:i9E2EC4A55EBCA544
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ERY8E7ERY8_HUMAN
Zinc finger protein 609
ZNF609
331Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti766D → N in BAA20755 (PubMed:9205841).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_059082250M → Q in isoform 2. 1
Alternative sequenceiVSP_059083251 – 1411Missing in isoform 2. Add BLAST1161

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC090543 Genomic DNA No translation available.
AB002293 mRNA Translation: BAA20755.1
BC110401 mRNA Translation: AAI10402.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32270.1 [O15014-1]

NCBI Reference Sequences

More...
RefSeqi
NP_055857.1, NM_015042.1 [O15014-1]
XP_011519688.1, XM_011521386.2 [O15014-1]
XP_016877510.1, XM_017022021.1 [O15014-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.595451
Hs.696256

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000326648; ENSP00000316527; ENSG00000180357 [O15014-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23060

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23060

UCSC genome browser

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UCSCi
uc002ann.4 human [O15014-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Protein Spotlight

Round in circles - Issue 199 of January 2018

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC090543 Genomic DNA No translation available.
AB002293 mRNA Translation: BAA20755.1
BC110401 mRNA Translation: AAI10402.1
CCDSiCCDS32270.1 [O15014-1]
RefSeqiNP_055857.1, NM_015042.1 [O15014-1]
XP_011519688.1, XM_011521386.2 [O15014-1]
XP_016877510.1, XM_017022021.1 [O15014-1]
UniGeneiHs.595451
Hs.696256

3D structure databases

ProteinModelPortaliO15014
SMRiO15014
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116695, 30 interactors
DIPiDIP-50012N
IntActiO15014, 13 interactors

PTM databases

iPTMnetiO15014
PhosphoSitePlusiO15014

Polymorphism and mutation databases

BioMutaiZNF609

Proteomic databases

EPDiO15014
jPOSTiO15014
MaxQBiO15014
PaxDbiO15014
PeptideAtlasiO15014
PRIDEiO15014
ProteomicsDBi48369

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326648; ENSP00000316527; ENSG00000180357 [O15014-1]
GeneIDi23060
KEGGihsa:23060
UCSCiuc002ann.4 human [O15014-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23060
EuPathDBiHostDB:ENSG00000180357.9

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF609
HGNCiHGNC:29003 ZNF609
HPAiHPA040742
HPA040832
MIMi617474 gene
neXtProtiNX_O15014
OpenTargetsiENSG00000180357
PharmGKBiPA134952302

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IQYG Eukaryota
ENOG410XRNB LUCA
GeneTreeiENSGT00390000008748
HOGENOMiHOG000082539
HOVERGENiHBG054557
InParanoidiO15014
OMAiKVKNDVC
OrthoDBi60503at2759
PhylomeDBiO15014
TreeFamiTF329775

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF609 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23060

Protein Ontology

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PROi
PR:O15014

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000180357 Expressed in 186 organ(s), highest expression level in testis
ExpressionAtlasiO15014 baseline and differential
GenevisibleiO15014 HS

Family and domain databases

InterProiView protein in InterPro
IPR040010 ZN608/ZN609
IPR013087 Znf_C2H2_type
PANTHERiPTHR21564 PTHR21564, 1 hit
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 1 hit
PS50157 ZINC_FINGER_C2H2_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN609_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15014
Secondary accession number(s): Q0D2I2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: February 13, 2019
This is version 135 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
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