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Protein

Rho guanine nucleotide exchange factor 10

Gene

ARHGEF10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in developmental myelination of peripheral nerves.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • guanyl-nucleotide exchange factor activity Source: GO_Central
  • kinesin binding Source: BHF-UCL
  • Rho guanyl-nucleotide exchange factor activity Source: BHF-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-193648 NRAGE signals death through JNK
R-HSA-194840 Rho GTPase cycle
R-HSA-416482 G alpha (12/13) signalling events

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 10
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARHGEF10
Synonyms:KIAA0294
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000104728.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14103 ARHGEF10

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608136 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O15013

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Slowed nerve conduction velocity (SNCV)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAffected individuals present a reduction in nerve conduction velocities without any clinical signs of peripheral or central nervous system dysfunction. SNCV inheritance is autosomal dominant.
See also OMIM:608236
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_019118357T → I in SNCV. 1 PublicationCorresponds to variant dbSNP:rs28940281Ensembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1338Q → R: Abolishes methylation by N6AMT1. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
9639

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
ARHGEF10

MalaCards human disease database

More...
MalaCardsi
ARHGEF10
MIMi608236 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000104728

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
140481 Autosomal dominant slowed nerve conduction velocity

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24967

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ARHGEF10

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000809261 – 1369Rho guanine nucleotide exchange factor 10Add BLAST1369

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei180PhosphoserineBy similarity1
Modified residuei379PhosphoserineCombined sources1
Modified residuei1287PhosphoserineCombined sources1
Modified residuei1338N5-methylglutamine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Methylated at Gln-1338 by N6AMT1.1 Publication

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O15013

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O15013

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O15013

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O15013

PeptideAtlas

More...
PeptideAtlasi
O15013

PRoteomics IDEntifications database

More...
PRIDEi
O15013

ProteomicsDB human proteome resource

More...
ProteomicsDBi
48364
48365 [O15013-4]
48366 [O15013-5]
48367 [O15013-6]
48368 [O15013-7]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O15013

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O15013

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000104728 Expressed in 227 organ(s), highest expression level in tibial nerve

CleanEx database of gene expression profiles

More...
CleanExi
HS_ARHGEF10

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O15013 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O15013 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA024649

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
KIF3BO150663EBI-2515636,EBI-3931791

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114998, 14 interactors

Protein interaction database and analysis system

More...
IntActi
O15013, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000340297

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O15013

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O15013

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini421 – 608DHPROSITE-ProRule annotationAdd BLAST188

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili304 – 355Sequence analysisAdd BLAST52

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1271 – 1304Ser-richAdd BLAST34

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3522 Eukaryota
ENOG410ZJK1 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153798

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000232060

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG050570

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O15013

KEGG Orthology (KO)

More...
KOi
K16727

Identification of Orthologs from Complete Genome Data

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OMAi
MCATVSA

Database of Orthologous Groups

More...
OrthoDBi
67600at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O15013

TreeFam database of animal gene trees

More...
TreeFami
TF331430

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00160 RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.900.10, 1 hit
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030632 ARHGEF10
IPR039919 ARHGEF10/ARHGEF17
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12877 PTHR12877, 1 hit
PTHR12877:SF14 PTHR12877:SF14, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00621 RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00325 RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065 SSF48065, 1 hit
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50010 DH_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O15013-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRPPGFLSRA PSLNRAERGI WSCSMDQREP LPPAPAENEM KYDTNNNEEE
60 70 80 90 100
EGEQFDFDSG DEIPEADRQA PSAPETGGAG ASEAPAPTGG EDGAGAETTP
110 120 130 140 150
VAEPTKLVLP MKVNPYSVID ITPFQEDQPP TPVPSAEEEN VGLHVPCGYL
160 170 180 190 200
VPVPCGYAVP SNLPLLLPAY SSPVIICATS LDEEAETPEV TEDRQPNSLS
210 220 230 240 250
SEEPPTSEDQ VGREDSALAR WAADPANTAW MENPEEAIYD DVPRENSDSE
260 270 280 290 300
PDEMIYDDVE NGDEGGNSSL EYGWSSSEFE SYEEQSDSEC KNGIPRSFLR
310 320 330 340 350
SNHKKQLSHD LTRLKEHYEK KMRDLMASTV GVVEIQQLRQ KHELKMQKLV
360 370 380 390 400
KAAKDGTKDG LERTRAAVKR GRSFIRTKSL IAQDHRSSLE EEQNLFIDVD
410 420 430 440 450
CKHPEAILTP MPEGLSQQQV VRRYILGSVV DSEKNYVDAL KRILEQYEKP
460 470 480 490 500
LSEMEPKVLS ERKLKTVFYR VKEILQCHSL FQIALASRVS EWDSVEMIGD
510 520 530 540 550
VFVASFSKSM VLDAYSEYVN NFSTAVAVLK KTCATKPAFL EFLKQEQEAS
560 570 580 590 600
PDRTTLYSLM MKPIQRFPQF ILLLQDMLKN TSKGHPDRLP LQMALTELET
610 620 630 640 650
LAEKLNERKR DADQRCEVKQ IAKAINERYL NKLLSSGSRY LIRSDDMIET
660 670 680 690 700
VYNDRGEIVK TKERRVFMLN DVLMCATVSS RPSHDSRVMS SQRYLLKWSV
710 720 730 740 750
PLGHVDAIEY GSSAGTGEHS RHLAVHPPES LAVVANAKPN KVYMGPGQLY
760 770 780 790 800
QDLQNLLHDL NVIGQITQLI GNLKGNYQNL NQSVAHDWTS GLQRLILKKE
810 820 830 840 850
DEIRAADCCR IQLQLPGKQD KSGRPTFFTA VFNTFTPAIK ESWVNSLQMA
860 870 880 890 900
KLALEEENHM GWFCVEDDGN HIKKEKHPLL VGHMPVMVAK QQEFKIECAA
910 920 930 940 950
YNPEPYLNNE SQPDSFSTAH GFLWIGSCTH QMGQIAIVSF QNSTPKVIEC
960 970 980 990 1000
FNVESRILCM LYVPVEEKRR EPGAPPDPET PAVRASDVPT ICVGTEEGSI
1010 1020 1030 1040 1050
SIYKSSQGSK KVRLQHFFTP EKSTVMSLAC TSQSLYAGLV NGAVASYARA
1060 1070 1080 1090 1100
PDGSWDSEPQ KVIKLGVLPV RSLLMMEDTL WAASGGQVFI ISVETHAVEG
1110 1120 1130 1140 1150
QLEAHQEEGM VISHMAVSGV GIWIAFTSGS TLRLFHTETL KHLQDINIAT
1160 1170 1180 1190 1200
PVHNMLPGHQ RLSVTSLLVC HGLLMVGTSL GVLVALPVPR LQGIPKVTGR
1210 1220 1230 1240 1250
GMVSYHAHNS PVKFIVLATA LHEKDKDKSR DSLAPGPEPQ DEDQKDALPS
1260 1270 1280 1290 1300
GGAGSSLSQG DPDAAIWLGD SLGSMTQKSD LSSSSGSLSL SHGSSSLEHR
1310 1320 1330 1340 1350
SEDSTIYDLL KDPVSLRSKA RRAKKAKASS ALVVCGGQGH RRVHRKARQP
1360
HQEELAPTVM VWQIPLLNI
Note: No experimental confirmation available.
Length:1,369
Mass (Da):151,612
Last modified:June 27, 2006 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6F87869C7C6A5759
GO
Isoform 2 (identifier: O15013-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     545-545: Missing.

Show »
Length:1,368
Mass (Da):151,483
Checksum:iDD1BB1820F4D85E4
GO
Isoform 3 (identifier: O15013-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.
     307-345: Missing.

Show »
Length:1,306
Mass (Da):144,269
Checksum:i051A631DCB20F225
GO
Isoform 4 (identifier: O15013-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     897-925: Missing.

Note: No experimental confirmation available.
Show »
Length:1,340
Mass (Da):148,328
Checksum:i80938B8E9F3189D1
GO
Isoform 5 (identifier: O15013-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.
     185-185: Missing.

Show »
Length:1,344
Mass (Da):148,869
Checksum:iE1BF9D9ACCB20E3A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YAN8H0YAN8_HUMAN
Rho guanine nucleotide exchange fac...
ARHGEF10
988Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PB39E9PB39_HUMAN
Rho guanine nucleotide exchange fac...
ARHGEF10
380Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH36809 differs from that shown. Probable cloning artifact.Curated
The sequence AAH40474 differs from that shown. Probable cloning artifact.Curated
The sequence BAA20754 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAH18365 differs from that shown. Reason: Erroneous termination at position 895. Translated as Lys.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti395L → F in AAI12927 (PubMed:15489334).Curated1
Sequence conflicti500D → V in AAH40474 (PubMed:15489334).Curated1
Sequence conflicti1024T → S in AAB71662 (PubMed:9314494).Curated1
Sequence conflicti1046S → T in AAB71662 (PubMed:9314494).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_073288227N → H Found in a patient with hereditary motor and sensory neuropathy; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs767902219Ensembl.1
Natural variantiVAR_019118357T → I in SNCV. 1 PublicationCorresponds to variant dbSNP:rs28940281Ensembl.1
Natural variantiVAR_038603700V → I. Corresponds to variant dbSNP:rs2294039EnsemblClinVar.1
Natural variantiVAR_057188725V → I. Corresponds to variant dbSNP:rs2294039EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0407541 – 24Missing in isoform 3 and isoform 5. 2 PublicationsAdd BLAST24
Alternative sequenceiVSP_040755185Missing in isoform 5. 1 Publication1
Alternative sequenceiVSP_040756307 – 345Missing in isoform 3. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_040757545Missing in isoform 2. 1 Publication1
Alternative sequenceiVSP_010704897 – 925Missing in isoform 4. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR749570 mRNA Translation: CAH18365.1 Different termination.
AB002292 mRNA Translation: BAA20754.2 Different initiation.
AC019257 Genomic DNA No translation available.
BC036809 mRNA Translation: AAH36809.1 Sequence problems.
BC040474 mRNA Translation: AAH40474.1 Sequence problems.
BC112926 mRNA Translation: AAI12927.1
AF009205 mRNA Translation: AAB71662.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS34794.1 [O15013-5]
CCDS78296.1 [O15013-6]
CCDS78297.1 [O15013-7]

Protein sequence database of the Protein Information Resource

More...
PIRi
T03307

NCBI Reference Sequences

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RefSeqi
NP_001295081.1, NM_001308152.1 [O15013-7]
NP_001295082.1, NM_001308153.1 [O15013-6]
NP_055444.2, NM_014629.3 [O15013-5]
XP_016869492.1, XM_017014003.1 [O15013-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.98594

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000349830; ENSP00000340297; ENSG00000104728 [O15013-5]
ENST00000398564; ENSP00000381571; ENSG00000104728 [O15013-1]
ENST00000518288; ENSP00000431012; ENSG00000104728 [O15013-6]
ENST00000520359; ENSP00000427909; ENSG00000104728 [O15013-7]
ENST00000610399; ENSP00000481974; ENSG00000274726 [O15013-1]
ENST00000619613; ENSP00000477988; ENSG00000274726 [O15013-5]
ENST00000631758; ENSP00000488343; ENSG00000274726 [O15013-7]
ENST00000633616; ENSP00000488463; ENSG00000274726 [O15013-6]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9639

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9639

UCSC genome browser

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UCSCi
uc003wpr.4 human [O15013-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR749570 mRNA Translation: CAH18365.1 Different termination.
AB002292 mRNA Translation: BAA20754.2 Different initiation.
AC019257 Genomic DNA No translation available.
BC036809 mRNA Translation: AAH36809.1 Sequence problems.
BC040474 mRNA Translation: AAH40474.1 Sequence problems.
BC112926 mRNA Translation: AAI12927.1
AF009205 mRNA Translation: AAB71662.1
CCDSiCCDS34794.1 [O15013-5]
CCDS78296.1 [O15013-6]
CCDS78297.1 [O15013-7]
PIRiT03307
RefSeqiNP_001295081.1, NM_001308152.1 [O15013-7]
NP_001295082.1, NM_001308153.1 [O15013-6]
NP_055444.2, NM_014629.3 [O15013-5]
XP_016869492.1, XM_017014003.1 [O15013-1]
UniGeneiHs.98594

3D structure databases

ProteinModelPortaliO15013
SMRiO15013
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114998, 14 interactors
IntActiO15013, 5 interactors
STRINGi9606.ENSP00000340297

PTM databases

iPTMnetiO15013
PhosphoSitePlusiO15013

Polymorphism and mutation databases

BioMutaiARHGEF10

Proteomic databases

EPDiO15013
jPOSTiO15013
MaxQBiO15013
PaxDbiO15013
PeptideAtlasiO15013
PRIDEiO15013
ProteomicsDBi48364
48365 [O15013-4]
48366 [O15013-5]
48367 [O15013-6]
48368 [O15013-7]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000349830; ENSP00000340297; ENSG00000104728 [O15013-5]
ENST00000398564; ENSP00000381571; ENSG00000104728 [O15013-1]
ENST00000518288; ENSP00000431012; ENSG00000104728 [O15013-6]
ENST00000520359; ENSP00000427909; ENSG00000104728 [O15013-7]
ENST00000610399; ENSP00000481974; ENSG00000274726 [O15013-1]
ENST00000619613; ENSP00000477988; ENSG00000274726 [O15013-5]
ENST00000631758; ENSP00000488343; ENSG00000274726 [O15013-7]
ENST00000633616; ENSP00000488463; ENSG00000274726 [O15013-6]
GeneIDi9639
KEGGihsa:9639
UCSCiuc003wpr.4 human [O15013-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9639
DisGeNETi9639
EuPathDBiHostDB:ENSG00000104728.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ARHGEF10
GeneReviewsiARHGEF10
HGNCiHGNC:14103 ARHGEF10
HPAiHPA024649
MalaCardsiARHGEF10
MIMi608136 gene
608236 phenotype
neXtProtiNX_O15013
OpenTargetsiENSG00000104728
Orphaneti140481 Autosomal dominant slowed nerve conduction velocity
PharmGKBiPA24967

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3522 Eukaryota
ENOG410ZJK1 LUCA
GeneTreeiENSGT00940000153798
HOGENOMiHOG000232060
HOVERGENiHBG050570
InParanoidiO15013
KOiK16727
OMAiMCATVSA
OrthoDBi67600at2759
PhylomeDBiO15013
TreeFamiTF331430

Enzyme and pathway databases

ReactomeiR-HSA-193648 NRAGE signals death through JNK
R-HSA-194840 Rho GTPase cycle
R-HSA-416482 G alpha (12/13) signalling events

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ARHGEF10 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ARHGEF10

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9639

Protein Ontology

More...
PROi
PR:O15013

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000104728 Expressed in 227 organ(s), highest expression level in tibial nerve
CleanExiHS_ARHGEF10
ExpressionAtlasiO15013 baseline and differential
GenevisibleiO15013 HS

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR030632 ARHGEF10
IPR039919 ARHGEF10/ARHGEF17
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR12877 PTHR12877, 1 hit
PTHR12877:SF14 PTHR12877:SF14, 1 hit
PfamiView protein in Pfam
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARHGA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15013
Secondary accession number(s): O14665
, Q2KHR8, Q68D55, Q8IWD9, Q8IY77
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: June 27, 2006
Last modified: January 16, 2019
This is version 160 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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