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Protein

Synapsin-3

Gene

SYN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the regulation of neurotransmitter release and synaptogenesis.

Miscellaneous

Regulated by calcium. Calcium inhibits ATP binding to the C-domain.

GO - Molecular functioni

  • ATP binding Source: ParkinsonsUK-UCL

GO - Biological processi

Keywordsi

LigandATP-binding, Calcium, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-181429 Serotonin Neurotransmitter Release Cycle
R-HSA-212676 Dopamine Neurotransmitter Release Cycle
SIGNORiO14994

Names & Taxonomyi

Protein namesi
Recommended name:
Synapsin-3
Alternative name(s):
Synapsin III
Gene namesi
Name:SYN3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000185666.14
HGNCiHGNC:11496 SYN3
MIMi602705 gene
neXtProtiNX_O14994

Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi8224
MalaCardsiSYN3
OpenTargetsiENSG00000185666
PharmGKBiPA36278

Polymorphism and mutation databases

BioMutaiSYN3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001830241 – 580Synapsin-3Add BLAST580

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9Phosphoserine; by PKA and CaMK1By similarity1
Modified residuei455PhosphoserineBy similarity1
Modified residuei462PhosphoserineBy similarity1
Modified residuei470Phosphoserine; by CDK1 and MAPK1 Publication1
Modified residuei475PhosphoserineBy similarity1
Modified residuei481PhosphoserineBy similarity1
Modified residuei484PhosphoserineBy similarity1
Modified residuei541PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation at Ser-9 dissociates synapsins from synaptic vesicles.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO14994
PaxDbiO14994
PeptideAtlasiO14994
PRIDEiO14994
ProteomicsDBi48363

PTM databases

iPTMnetiO14994
PhosphoSitePlusiO14994

Expressioni

Tissue specificityi

Neuron specific. Detected predominantly in brain.

Gene expression databases

BgeeiENSG00000185666 Expressed in 109 organ(s), highest expression level in primary visual cortex
CleanExiHS_SYN3
ExpressionAtlasiO14994 baseline and differential
GenevisibleiO14994 HS

Organism-specific databases

HPAiHPA034566

Interactioni

Subunit structurei

Interacts with CAPON.By similarity

Protein-protein interaction databases

BioGridi113857, 3 interactors
STRINGi9606.ENSP00000330219

Structurei

Secondary structure

1580
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO14994
SMRiO14994
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO14994

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 28AAdd BLAST28
Regioni28 – 90B; linkerAdd BLAST63
Regioni91 – 399C; actin-binding and synaptic-vesicle bindingAdd BLAST309
Regioni400 – 531J; Pro-rich linkerAdd BLAST132
Regioni532 – 580EAdd BLAST49

Domaini

The A region binds phospholipids with a preference for negatively charged species.By similarity

Sequence similaritiesi

Belongs to the synapsin family.Curated

Phylogenomic databases

eggNOGiKOG3895 Eukaryota
ENOG410XQH5 LUCA
GeneTreeiENSGT00530000063319
HOVERGENiHBG016354
InParanoidiO14994
KOiK19941
OMAiNHKPMLT
OrthoDBiEOG091G0BZ1
PhylomeDBiO14994
TreeFamiTF319919

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
InterProiView protein in InterPro
IPR013815 ATP_grasp_subdomain_1
IPR016185 PreATP-grasp_dom_sf
IPR028712 SYN3
IPR001359 Synapsin
IPR020898 Synapsin_ATP-bd_dom
IPR019735 Synapsin_CS
IPR019736 Synapsin_P_site
IPR020897 Synapsin_pre-ATP-grasp_dom
PANTHERiPTHR10841 PTHR10841, 1 hit
PTHR10841:SF6 PTHR10841:SF6, 1 hit
PfamiView protein in Pfam
PF02078 Synapsin, 1 hit
PF02750 Synapsin_C, 1 hit
PF10581 Synapsin_N, 1 hit
PRINTSiPR01368 SYNAPSIN
SUPFAMiSSF52440 SSF52440, 1 hit
PROSITEiView protein in PROSITE
PS00415 SYNAPSIN_1, 1 hit
PS00416 SYNAPSIN_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

O14994-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNFLRRRLSD SSFMANLPNG YMTDLQRPDS STSSPASPAM ERRHPQPLAA
60 70 80 90 100
SFSSPGSSLF SSLSSAMKQA PQATSGLMEP PGPSTPIVQR PRILLVIDDA
110 120 130 140 150
HTDWSKYFHG KKVNGEIEIR VEQAEFSELN LAAYVTGGCM VDMQVVRNGT
160 170 180 190 200
KVVSRSFKPD FILVRQHAYS MALGEDYRSL VIGLQYGGLP AVNSLYSVYN
210 220 230 240 250
FCSKPWVFSQ LIKIFHSLGP EKFPLVEQTF FPNHKPMVTA PHFPVVVKLG
260 270 280 290 300
HAHAGMGKIK VENQLDFQDI TSVVAMAKTY ATTEAFIDSK YDIRIQKIGS
310 320 330 340 350
NYKAYMRTSI SGNWKANTGS AMLEQVAMTE RYRLWVDSCS EMFGGLDICA
360 370 380 390 400
VKAVHSKDGR DYIIEVMDSS MPLIGEHVEE DRQLMADLVV SKMSQLPMPG
410 420 430 440 450
GTAPSPLRPW APQIKSAKSP GQAQLGPQLG QPQPRPPPQG GPRQAQSPQP
460 470 480 490 500
QRSGSPSQQR LSPQGQQPLS PQSGSPQQQR SPGSPQLSRA SSGSSPNQAS
510 520 530 540 550
KPGATLASQP RPPVQGRSTS QQGEESKKPA PPHPHLNKSQ SLTNSLSTSD
560 570 580
TSQRGTPSED EAKAETIRNL RKSFASLFSD
Length:580
Mass (Da):63,303
Last modified:November 1, 1998 - v2
Checksum:i4F61DE236DE8F3C5
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6ZJ82A6ZJ82_HUMAN
Synapsin-3
SYN3
123Annotation score:
Q4TT46Q4TT46_HUMAN
Synapsin-3
SYN3
113Annotation score:
A0A0A0MR68A0A0A0MR68_HUMAN
Synapsin-3
SYN3
323Annotation score:
A0A087WTG8A0A087WTG8_HUMAN
Synapsin-3
SYN3
187Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_068906470S → N in patients affected by schizophrenia. 1 PublicationCorresponds to variant dbSNP:rs5998526Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF046873 mRNA Translation: AAC15101.1
CR456589 mRNA Translation: CAG30475.1
Z83846 Genomic DNA No translation available.
Z71183 Genomic DNA No translation available.
Z98256 Genomic DNA No translation available.
Z82181 Genomic DNA No translation available.
Z82246 Genomic DNA No translation available.
Z80902 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60034.1
BC075065 mRNA Translation: AAH75065.1
BC075066 mRNA Translation: AAH75066.1
BC143874 mRNA Translation: AAI43875.1
CCDSiCCDS13908.1
RefSeqiNP_003481.3, NM_003490.3
NP_598344.2, NM_133633.2
XP_011528707.1, XM_011530405.2
XP_011528708.1, XM_011530406.2
XP_011528709.1, XM_011530407.2
XP_011528710.1, XM_011530408.1
XP_016884449.1, XM_017028960.1
XP_016884450.1, XM_017028961.1
XP_016884451.1, XM_017028962.1
XP_016884452.1, XM_017028963.1
UniGeneiHs.608750

Genome annotation databases

EnsembliENST00000358763; ENSP00000351614; ENSG00000185666
GeneIDi8224
KEGGihsa:8224
UCSCiuc003amx.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF046873 mRNA Translation: AAC15101.1
CR456589 mRNA Translation: CAG30475.1
Z83846 Genomic DNA No translation available.
Z71183 Genomic DNA No translation available.
Z98256 Genomic DNA No translation available.
Z82181 Genomic DNA No translation available.
Z82246 Genomic DNA No translation available.
Z80902 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60034.1
BC075065 mRNA Translation: AAH75065.1
BC075066 mRNA Translation: AAH75066.1
BC143874 mRNA Translation: AAI43875.1
CCDSiCCDS13908.1
RefSeqiNP_003481.3, NM_003490.3
NP_598344.2, NM_133633.2
XP_011528707.1, XM_011530405.2
XP_011528708.1, XM_011530406.2
XP_011528709.1, XM_011530407.2
XP_011528710.1, XM_011530408.1
XP_016884449.1, XM_017028960.1
XP_016884450.1, XM_017028961.1
XP_016884451.1, XM_017028962.1
XP_016884452.1, XM_017028963.1
UniGeneiHs.608750

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2P0AX-ray1.90A/B76-417[»]
ProteinModelPortaliO14994
SMRiO14994
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113857, 3 interactors
STRINGi9606.ENSP00000330219

PTM databases

iPTMnetiO14994
PhosphoSitePlusiO14994

Polymorphism and mutation databases

BioMutaiSYN3

Proteomic databases

EPDiO14994
PaxDbiO14994
PeptideAtlasiO14994
PRIDEiO14994
ProteomicsDBi48363

Protocols and materials databases

DNASUi8224
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358763; ENSP00000351614; ENSG00000185666
GeneIDi8224
KEGGihsa:8224
UCSCiuc003amx.4 human

Organism-specific databases

CTDi8224
DisGeNETi8224
EuPathDBiHostDB:ENSG00000185666.14
GeneCardsiSYN3
HGNCiHGNC:11496 SYN3
HPAiHPA034566
MalaCardsiSYN3
MIMi602705 gene
neXtProtiNX_O14994
OpenTargetsiENSG00000185666
PharmGKBiPA36278
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3895 Eukaryota
ENOG410XQH5 LUCA
GeneTreeiENSGT00530000063319
HOVERGENiHBG016354
InParanoidiO14994
KOiK19941
OMAiNHKPMLT
OrthoDBiEOG091G0BZ1
PhylomeDBiO14994
TreeFamiTF319919

Enzyme and pathway databases

ReactomeiR-HSA-181429 Serotonin Neurotransmitter Release Cycle
R-HSA-212676 Dopamine Neurotransmitter Release Cycle
SIGNORiO14994

Miscellaneous databases

ChiTaRSiSYN3 human
EvolutionaryTraceiO14994
GeneWikiiSYN3
GenomeRNAii8224
PROiPR:O14994
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185666 Expressed in 109 organ(s), highest expression level in primary visual cortex
CleanExiHS_SYN3
ExpressionAtlasiO14994 baseline and differential
GenevisibleiO14994 HS

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
InterProiView protein in InterPro
IPR013815 ATP_grasp_subdomain_1
IPR016185 PreATP-grasp_dom_sf
IPR028712 SYN3
IPR001359 Synapsin
IPR020898 Synapsin_ATP-bd_dom
IPR019735 Synapsin_CS
IPR019736 Synapsin_P_site
IPR020897 Synapsin_pre-ATP-grasp_dom
PANTHERiPTHR10841 PTHR10841, 1 hit
PTHR10841:SF6 PTHR10841:SF6, 1 hit
PfamiView protein in Pfam
PF02078 Synapsin, 1 hit
PF02750 Synapsin_C, 1 hit
PF10581 Synapsin_N, 1 hit
PRINTSiPR01368 SYNAPSIN
SUPFAMiSSF52440 SSF52440, 1 hit
PROSITEiView protein in PROSITE
PS00415 SYNAPSIN_1, 1 hit
PS00416 SYNAPSIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSYN3_HUMAN
AccessioniPrimary (citable) accession number: O14994
Secondary accession number(s): B1B1F9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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