UniProtKB - O14986 (PI51B_HUMAN)
Protein
Phosphatidylinositol 4-phosphate 5-kinase type-1 beta
Gene
PIP5K1B
Organism
Homo sapiens (Human)
Status
Functioni
Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2. Together with PIP5K1A is required after stimulation of G-protein coupled receptors for stable platelet adhesion (By similarity).By similarity
Caution
There is confusion in the literature with phosphatidylinositol 4-phosphate 5-kinase type I nomenclature due to the fact that frequently mouse PIP5K1B is named Phosphatidylinositol 4-phosphate 5-kinase type I alpha.Curated
Catalytic activityi
- 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H+EC:2.7.1.68
GO - Molecular functioni
- 1-phosphatidylinositol-3-phosphate 4-kinase activity Source: Reactome
- 1-phosphatidylinositol-3-phosphate 5-kinase activity Source: Reactome
- 1-phosphatidylinositol-4-phosphate 5-kinase activity Source: Reactome
- 1-phosphatidylinositol-5-kinase activity Source: Reactome
- ATP binding Source: UniProtKB-KW
- phosphatidylinositol-3,4-bisphosphate 5-kinase activity Source: Reactome
GO - Biological processi
- phosphatidylinositol biosynthetic process Source: Reactome
- regulation of phosphatidylinositol 3-kinase signaling Source: Reactome
Keywordsi
Molecular function | Kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | MetaCyc:HS02982-MONOMER |
Reactomei | R-HSA-1660499 Synthesis of PIPs at the plasma membrane R-HSA-201688 WNT mediated activation of DVL R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
SABIO-RKi | O14986 |
SIGNORi | O14986 |
Names & Taxonomyi
Protein namesi | Recommended name: Phosphatidylinositol 4-phosphate 5-kinase type-1 beta (EC:2.7.1.68)Short name: PIP5K1-beta Short name: PtdIns(4)P-5-kinase 1 beta Alternative name(s): Phosphatidylinositol 4-phosphate 5-kinase type I beta Short name: PIP5KIbeta Protein STM-7 Type I phosphatidylinositol 4-phosphate 5-kinase beta |
Gene namesi | Name:PIP5K1B Synonyms:STM7 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000107242.17 |
HGNCi | HGNC:8995 PIP5K1B |
MIMi | 602745 gene |
neXtProti | NX_O14986 |
Subcellular locationi
Other locations
- Endomembrane system By similarity
Note: Associated with membranes.By similarity
Cytosol
- cytosol Source: Reactome
Other locations
- endomembrane system Source: UniProtKB-SubCell
- membrane Source: UniProtKB-KW
- uropod Source: UniProtKB
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 8395 |
OpenTargetsi | ENSG00000107242 |
PharmGKBi | PA33328 |
Polymorphism and mutation databases
BioMutai | PIP5K1B |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000185458 | 1 – 540 | Phosphatidylinositol 4-phosphate 5-kinase type-1 betaAdd BLAST | 540 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 445 | PhosphoserineBy similarity | 1 | |
Modified residuei | 447 | PhosphoserineBy similarity | 1 | |
Modified residuei | 448 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | O14986 |
jPOSTi | O14986 |
MaxQBi | O14986 |
PaxDbi | O14986 |
PeptideAtlasi | O14986 |
PRIDEi | O14986 |
ProteomicsDBi | 48360 48361 [O14986-2] |
PTM databases
iPTMneti | O14986 |
PhosphoSitePlusi | O14986 |
SwissPalmi | O14986 |
Expressioni
Tissue specificityi
Detected in heart, pancreas, brain, kidney, skeletal muscle and lung.1 Publication
Gene expression databases
Bgeei | ENSG00000107242 Expressed in 195 organ(s), highest expression level in choroid plexus epithelium |
ExpressionAtlasi | O14986 baseline and differential |
Genevisiblei | O14986 HS |
Organism-specific databases
HPAi | HPA009687 |
Interactioni
Subunit structurei
Interacts with RAC1, AJUBA, PLD1, PLD2 and ARF1.By similarity
Protein-protein interaction databases
BioGridi | 113984, 3 interactors |
CORUMi | O14986 |
STRINGi | 9606.ENSP00000265382 |
Structurei
3D structure databases
ProteinModelPortali | O14986 |
SMRi | O14986 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 395 | PIPKPROSITE-ProRule annotationAdd BLAST | 371 |
Phylogenomic databases
eggNOGi | KOG0229 Eukaryota COG5253 LUCA |
GeneTreei | ENSGT00940000156639 |
HOVERGENi | HBG052818 |
InParanoidi | O14986 |
KOi | K00889 |
OMAi | KMHFTYD |
OrthoDBi | 1562683at2759 |
PhylomeDBi | O14986 |
TreeFami | TF319618 |
Family and domain databases
Gene3Di | 3.30.800.10, 1 hit 3.30.810.10, 2 hits |
InterProi | View protein in InterPro IPR023610 PInositol-4-P-5-kinase IPR027483 PInositol-4-P-5-kinase_C IPR002498 PInositol-4-P-5-kinase_core IPR027484 PInositol-4-P-5-kinase_N |
PANTHERi | PTHR23086 PTHR23086, 1 hit |
Pfami | View protein in Pfam PF01504 PIP5K, 1 hit |
SMARTi | View protein in SMART SM00330 PIPKc, 1 hit |
PROSITEi | View protein in PROSITE PS51455 PIPK, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O14986-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MSSAAENGEA APGKQNEEKT YKKTASSAIK GAIQLGIGYT VGNLTSKPER
60 70 80 90 100
DVLMQDFYVV ESVFLPSEGS NLTPAHHYPD FRFKTYAPLA FRYFRELFGI
110 120 130 140 150
KPDDYLYSIC SEPLIELSNP GASGSLFFVT SDDEFIIKTV QHKEAEFLQK
160 170 180 190 200
LLPGYYMNLN QNPRTLLPKF YGLYCMQSGG INIRIVVMNN VLPRSMRMHF
210 220 230 240 250
TYDLKGSTYK RRASRKEREK SNPTFKDLDF LQDMHEGLYF DTETYNALMK
260 270 280 290 300
TLQRDCRVLE SFKIMDYSLL LGIHFLDHSL KEKEEETPQN VPDAKRTGMQ
310 320 330 340 350
KVLYSTAMES IQGPGKSGDG IITENPDTMG GIPAKSHRGE KLLLFMGIID
360 370 380 390 400
ILQSYRLMKK LEHSWKALVY DGDTVSVHRP SFYADRFLKF MNSRVFKKIQ
410 420 430 440 450
ALKASPSKKR CNSIAALKAT SQEIVSSISQ EWKDEKRDLL TEGQSFSSLD
460 470 480 490 500
EEALGSRHRP DLVPSTPSLF EAASLATTIS SSSLYVNEHY PHDRPTLYSN
510 520 530 540
SKGLPSSSTF TLEEGTIYLT AEPNTLEVQD DNASVLDVYL
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MSP5 | A0A0A0MSP5_HUMAN | Phosphatidylinositol 4-phosphate 5-... | PIP5K1B | 162 | Annotation score: | ||
A0A0A0MT25 | A0A0A0MT25_HUMAN | Phosphatidylinositol 4-phosphate 5-... | PIP5K1B | 157 | Annotation score: | ||
A0A0A0MRU3 | A0A0A0MRU3_HUMAN | Phosphatidylinositol 4-phosphate 5-... | PIP5K1B | 103 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 346 | M → T in AAH30587 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_023712 | 415 | A → T1 PublicationCorresponds to variant dbSNP:rs55897616Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_016010 | 24 | T → TQVKNQILSRLPKIPCTFIQ AWTNTEMITLLACYYFRSVS T in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_016011 | 501 – 540 | SKGLP…LDVYL → RFKMATSEH in isoform 2. 1 PublicationAdd BLAST | 40 | |
Alternative sequenceiVSP_054771 | 503 – 540 | Missing in isoform 3. 1 PublicationAdd BLAST | 38 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000265382; ENSP00000265382; ENSG00000107242 [O14986-1] ENST00000478500; ENSP00000435778; ENSG00000107242 [O14986-2] ENST00000541509; ENSP00000438082; ENSG00000107242 [O14986-3] |
GeneIDi | 8395 |
KEGGi | hsa:8395 |
UCSCi | uc004agu.5 human [O14986-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
ProteinModelPortali | O14986 |
SMRi | O14986 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 113984, 3 interactors |
CORUMi | O14986 |
STRINGi | 9606.ENSP00000265382 |
PTM databases
iPTMneti | O14986 |
PhosphoSitePlusi | O14986 |
SwissPalmi | O14986 |
Polymorphism and mutation databases
BioMutai | PIP5K1B |
Proteomic databases
EPDi | O14986 |
jPOSTi | O14986 |
MaxQBi | O14986 |
PaxDbi | O14986 |
PeptideAtlasi | O14986 |
PRIDEi | O14986 |
ProteomicsDBi | 48360 48361 [O14986-2] |
Protocols and materials databases
DNASUi | 8395 |
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000265382; ENSP00000265382; ENSG00000107242 [O14986-1] ENST00000478500; ENSP00000435778; ENSG00000107242 [O14986-2] ENST00000541509; ENSP00000438082; ENSG00000107242 [O14986-3] |
GeneIDi | 8395 |
KEGGi | hsa:8395 |
UCSCi | uc004agu.5 human [O14986-1] |
Organism-specific databases
CTDi | 8395 |
DisGeNETi | 8395 |
EuPathDBi | HostDB:ENSG00000107242.17 |
GeneCardsi | PIP5K1B |
HGNCi | HGNC:8995 PIP5K1B |
HPAi | HPA009687 |
MIMi | 602745 gene |
neXtProti | NX_O14986 |
OpenTargetsi | ENSG00000107242 |
PharmGKBi | PA33328 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0229 Eukaryota COG5253 LUCA |
GeneTreei | ENSGT00940000156639 |
HOVERGENi | HBG052818 |
InParanoidi | O14986 |
KOi | K00889 |
OMAi | KMHFTYD |
OrthoDBi | 1562683at2759 |
PhylomeDBi | O14986 |
TreeFami | TF319618 |
Enzyme and pathway databases
BioCyci | MetaCyc:HS02982-MONOMER |
Reactomei | R-HSA-1660499 Synthesis of PIPs at the plasma membrane R-HSA-201688 WNT mediated activation of DVL R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
SABIO-RKi | O14986 |
SIGNORi | O14986 |
Miscellaneous databases
ChiTaRSi | PIP5K1B human |
GeneWikii | PIP5K1B |
GenomeRNAii | 8395 |
PROi | PR:O14986 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000107242 Expressed in 195 organ(s), highest expression level in choroid plexus epithelium |
ExpressionAtlasi | O14986 baseline and differential |
Genevisiblei | O14986 HS |
Family and domain databases
Gene3Di | 3.30.800.10, 1 hit 3.30.810.10, 2 hits |
InterProi | View protein in InterPro IPR023610 PInositol-4-P-5-kinase IPR027483 PInositol-4-P-5-kinase_C IPR002498 PInositol-4-P-5-kinase_core IPR027484 PInositol-4-P-5-kinase_N |
PANTHERi | PTHR23086 PTHR23086, 1 hit |
Pfami | View protein in Pfam PF01504 PIP5K, 1 hit |
SMARTi | View protein in SMART SM00330 PIPKc, 1 hit |
PROSITEi | View protein in PROSITE PS51455 PIPK, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | PI51B_HUMAN | |
Accessioni | O14986Primary (citable) accession number: O14986 Secondary accession number(s): A8K9L9 Q92749 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 25, 2005 |
Last sequence update: | October 25, 2005 | |
Last modified: | February 13, 2019 | |
This is version 142 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations