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Protein

TATA-binding protein-associated factor 172

Gene

BTAF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box in an ATP-dependent manner.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1291 – 1298ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • DNA binding Source: UniProtKB-KW
  • DNA-binding transcription factor activity Source: UniProtKB
  • helicase activity Source: UniProtKB-KW

GO - Biological processi

  • negative regulation of chromatin binding Source: MGI
  • negative regulation of transcription, DNA-templated Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Helicase, Hydrolase
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TATA-binding protein-associated factor 172 (EC:3.6.4.-)
Alternative name(s):
ATP-dependent helicase BTAF1
B-TFIID transcription factor-associated 170 kDa subunit
TAF(II)170
TBP-associated factor 172
Short name:
TAF-172
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BTAF1
Synonyms:TAF172
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000095564.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17307 BTAF1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605191 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O14981

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9044

Open Targets

More...
OpenTargetsi
ENSG00000095564

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25437

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BTAF1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000743111 – 1849TATA-binding protein-associated factor 172Add BLAST1849

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei91PhosphoserineCombined sources1
Modified residuei95PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O14981

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O14981

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O14981

PeptideAtlas

More...
PeptideAtlasi
O14981

PRoteomics IDEntifications database

More...
PRIDEi
O14981

ProteomicsDB human proteome resource

More...
ProteomicsDBi
48357

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O14981

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O14981

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000095564 Expressed in 237 organ(s), highest expression level in epithelial cell of pancreas

CleanEx database of gene expression profiles

More...
CleanExi
HS_BTAF1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O14981 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O14981 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA070682

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with TBP to form B-TFIID. Binds DRAP1.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114506, 55 interactors

Protein interaction database and analysis system

More...
IntActi
O14981, 19 interactors

Molecular INTeraction database

More...
MINTi
O14981

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000265990

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O14981

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati385 – 422HEAT 1Add BLAST38
Repeati426 – 463HEAT 2Add BLAST38
Repeati513 – 550HEAT 3Add BLAST38
Repeati554 – 596HEAT 4Add BLAST43
Repeati818 – 855HEAT 5Add BLAST38
Repeati872 – 910HEAT 6Add BLAST39
Repeati1102 – 1139HEAT 7Add BLAST38
Repeati1182 – 1219HEAT 8Add BLAST38
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1278 – 1453Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST176
Domaini1636 – 1790Helicase C-terminalPROSITE-ProRule annotationAdd BLAST155

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi191 – 207Nuclear localization signalSequence analysisAdd BLAST17
Motifi1404 – 1407DEGH box4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0387 Eukaryota
ENOG410XP4Z LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157500

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000210415

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG017883

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O14981

KEGG Orthology (KO)

More...
KOi
K15192

Identification of Orthologs from Complete Genome Data

More...
OMAi
ALIFCQM

Database of Orthologous Groups

More...
OrthoDBi
61251at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O14981

TreeFam database of animal gene trees

More...
TreeFami
TF300546

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00079 HELICc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 2 hits
3.40.50.10810, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR022707 DUF3535
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12054 DUF3535, 1 hit
PF00271 Helicase_C, 1 hit
PF00176 SNF2_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O14981-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVSRLDRLF ILLDTGTTPV TRKAAAQQLG EVVKLHPHEL NNLLSKVLIY
60 70 80 90 100
LRSANWDTRI AAGQAVEAIV KNVPEWNPVP RTRQEPTSES SMEDSPTTER
110 120 130 140 150
LNFDRFDICR LLQHGASLLG SAGAEFEVQD EKSGEVDPKE RIARQRKLLQ
160 170 180 190 200
KKLGLNMGEA IGMSTEELFN DEDLDYTPTS ASFVNKQPTL QAAELIDSEF
210 220 230 240 250
RAGMSNRQKN KAKRMAKLFA KQRSRDAVET NEKSNDSTDG EPEEKRRKIA
260 270 280 290 300
NVVINQSAND SKVLIDNIPD SSSLIEETNE WPLESFCEEL CNDLFNPSWE
310 320 330 340 350
VRHGAGTGLR EILKAHGKSG GKMGDSTLEE MIQQHQEWLE DLVIRLLCVF
360 370 380 390 400
ALDRFGDFVS DEVVAPVRET CAQTLGVVLK HMNETGVHKT VDVLLKLLTQ
410 420 430 440 450
EQWEVRHGGL LGIKYALAVR QDVINTLLPK VLTRIIEGLQ DLDDDVRAVA
460 470 480 490 500
AASLVPVVES LVYLQTQKVP FIINTLWDAL LELDDLTAST NSIMTLLSSL
510 520 530 540 550
LTYPQVQQCS IQQSLTVLVP RVWPFLHHTI SSVRRAALET LFTLLSTQDQ
560 570 580 590 600
NSSSWLIPIL PDMLRHIFQF CVLESSQEIL DLIHKVWMEL LSKASVQYVV
610 620 630 640 650
AAACPWMGAW LCLMMQPSHL PIDLNMLLEV KARAKEKTGG KVRQGQSQNK
660 670 680 690 700
EVLQEYIAGA DTIMEDPATR DFVVMRARMM AAKLLGALCC CICDPGVNVV
710 720 730 740 750
TQEIKPAESL GQLLLFHLNS KSALQRISVA LVICEWAALQ KECKAVTLAV
760 770 780 790 800
QPRLLDILSE HLYYDEIAVP FTRMQNECKQ LISSLADVHI EVGNRVNNNV
810 820 830 840 850
LTIDQASDLV TTVFNEATSS FDLNPQVLQQ LDSKRQQVQM TVTETNQEWQ
860 870 880 890 900
VLQLRVHTFA ACAVVSLQQL PEKLNPIIKP LMETIKKEEN TLVQNYAAQC
910 920 930 940 950
IAKLLQQCTT RTPCPNSKII KNLCSSLCVD PYLTPCVTCP VPTQSGQENS
960 970 980 990 1000
KGSTSEKDGM HHTVTKHRGI ITLYRHQKAA FAITSRRGPT PKAVKAQIAD
1010 1020 1030 1040 1050
LPAGSSGNIL VELDEAQKPY LVQRRGAEFA LTTIVKHFGG EMAVKLPHLW
1060 1070 1080 1090 1100
DAMVGPLRNT IDINNFDGKS LLDKGDSPAQ ELVNSLQVFE TAAASMDSEL
1110 1120 1130 1140 1150
HPLLVQHLPH LYMCLQYPST AVRHMAARCV GVMSKIATME TMNIFLEKVL
1160 1170 1180 1190 1200
PWLGAIDDSV KQEGAIEALA CVMEQLDVGI VPYIVLLVVP VLGRMSDQTD
1210 1220 1230 1240 1250
SVRFMATQCF ATLIRLMPLE AGIPDPPNMS AELIQLKAKE RHFLEQLLDG
1260 1270 1280 1290 1300
KKLENYKIPV PINAELRKYQ QDGVNWLAFL NKYKLHGILC DDMGLGKTLQ
1310 1320 1330 1340 1350
SICILAGDHC HRAQEYARSK LAECMPLPSL VVCPPTLTGH WVDEVGKFCS
1360 1370 1380 1390 1400
REYLNPLHYT GPPTERIRLQ HQVKRHNLIV ASYDVVRNDI DFFRNIKFNY
1410 1420 1430 1440 1450
CILDEGHVIK NGKTKLSKAV KQLTANYRII LSGTPIQNNV LELWSLFDFL
1460 1470 1480 1490 1500
MPGFLGTERQ FAARYGKPIL ASRDARSSSR EQEAGVLAMD ALHRQVLPFL
1510 1520 1530 1540 1550
LRRMKEDVLQ DLPPKIIQDY YCTLSPLQVQ LYEDFAKSRA KCDVDETVSS
1560 1570 1580 1590 1600
ATLSEETEKP KLKATGHVFQ ALQYLRKLCN HPALVLTPQH PEFKTTAEKL
1610 1620 1630 1640 1650
AVQNSSLHDI QHAPKLSALK QLLLDCGLGN GSTSESGTES VVAQHRILIF
1660 1670 1680 1690 1700
CQLKSMLDIV EHDLLKPHLP SVTYLRLDGS IPPGQRHSIV SRFNNDPSID
1710 1720 1730 1740 1750
VLLLTTHVGG LGLNLTGADT VVFVEHDWNP MRDLQAMDRA HRIGQKRVVN
1760 1770 1780 1790 1800
VYRLITRGTL EEKIMGLQKF KMNIANTVIS QENSSLQSMG TDQLLDLFTL
1810 1820 1830 1840
DKDGKAEKAD TSTSGKASMK SILENLSDLW DQEQYDSEYS LENFMHSLK
Length:1,849
Mass (Da):206,887
Last modified:August 1, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFE3675B75A44F113
GO
Isoform 2 (identifier: O14981-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1172: Missing.

Note: No experimental confirmation available.
Show »
Length:677
Mass (Da):76,419
Checksum:iDA3558BDAEF2B0D0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MTH9A0A0A0MTH9_HUMAN
TATA-binding protein-associated fac...
BTAF1
1,849Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0565101 – 1172Missing in isoform 2. 1 PublicationAdd BLAST1172

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ001017 mRNA Translation: CAA04475.1
AF038362 mRNA Translation: AAC04573.1
AK303554 mRNA Translation: BAG64578.1
AL359198 Genomic DNA No translation available.
AL365398 Genomic DNA No translation available.
AF166118 Genomic DNA Translation: AAF37803.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7419.1 [O14981-1]

NCBI Reference Sequences

More...
RefSeqi
NP_003963.1, NM_003972.2 [O14981-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.500526

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000265990; ENSP00000265990; ENSG00000095564 [O14981-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9044

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9044

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001017 mRNA Translation: CAA04475.1
AF038362 mRNA Translation: AAC04573.1
AK303554 mRNA Translation: BAG64578.1
AL359198 Genomic DNA No translation available.
AL365398 Genomic DNA No translation available.
AF166118 Genomic DNA Translation: AAF37803.1
CCDSiCCDS7419.1 [O14981-1]
RefSeqiNP_003963.1, NM_003972.2 [O14981-1]
UniGeneiHs.500526

3D structure databases

ProteinModelPortaliO14981
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114506, 55 interactors
IntActiO14981, 19 interactors
MINTiO14981
STRINGi9606.ENSP00000265990

PTM databases

iPTMnetiO14981
PhosphoSitePlusiO14981

Polymorphism and mutation databases

BioMutaiBTAF1

Proteomic databases

EPDiO14981
jPOSTiO14981
PaxDbiO14981
PeptideAtlasiO14981
PRIDEiO14981
ProteomicsDBi48357

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265990; ENSP00000265990; ENSG00000095564 [O14981-1]
GeneIDi9044
KEGGihsa:9044

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9044
DisGeNETi9044
EuPathDBiHostDB:ENSG00000095564.13

GeneCards: human genes, protein and diseases

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GeneCardsi
BTAF1
HGNCiHGNC:17307 BTAF1
HPAiHPA070682
MIMi605191 gene
neXtProtiNX_O14981
OpenTargetsiENSG00000095564
PharmGKBiPA25437

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0387 Eukaryota
ENOG410XP4Z LUCA
GeneTreeiENSGT00940000157500
HOGENOMiHOG000210415
HOVERGENiHBG017883
InParanoidiO14981
KOiK15192
OMAiALIFCQM
OrthoDBi61251at2759
PhylomeDBiO14981
TreeFamiTF300546

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
BTAF1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
BTAF1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9044

Protein Ontology

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PROi
PR:O14981

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000095564 Expressed in 237 organ(s), highest expression level in epithelial cell of pancreas
CleanExiHS_BTAF1
ExpressionAtlasiO14981 baseline and differential
GenevisibleiO14981 HS

Family and domain databases

CDDicd00079 HELICc, 1 hit
Gene3Di1.25.10.10, 2 hits
3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR022707 DUF3535
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
PfamiView protein in Pfam
PF12054 DUF3535, 1 hit
PF00271 Helicase_C, 1 hit
PF00176 SNF2_N, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBTAF1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O14981
Secondary accession number(s): B4E0W6, O43578
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 1, 1998
Last modified: January 16, 2019
This is version 179 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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