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Protein

TATA-binding protein-associated factor 172

Gene

BTAF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box in an ATP-dependent manner.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi1291 – 1298ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • DNA binding Source: UniProtKB-KW
  • DNA-binding transcription factor activity Source: UniProtKB
  • helicase activity Source: UniProtKB-KW

GO - Biological processi

  • negative regulation of chromatin binding Source: MGI
  • negative regulation of transcription, DNA-templated Source: UniProtKB

Keywordsi

Molecular functionDNA-binding, Helicase, Hydrolase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
TATA-binding protein-associated factor 172 (EC:3.6.4.-)
Alternative name(s):
ATP-dependent helicase BTAF1
B-TFIID transcription factor-associated 170 kDa subunit
TAF(II)170
TBP-associated factor 172
Short name:
TAF-172
Gene namesi
Name:BTAF1
Synonyms:TAF172
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000095564.13
HGNCiHGNC:17307 BTAF1
MIMi605191 gene
neXtProtiNX_O14981

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9044
OpenTargetsiENSG00000095564
PharmGKBiPA25437

Polymorphism and mutation databases

BioMutaiBTAF1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000743111 – 1849TATA-binding protein-associated factor 172Add BLAST1849

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei91PhosphoserineCombined sources1
Modified residuei95PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO14981
PaxDbiO14981
PeptideAtlasiO14981
PRIDEiO14981
ProteomicsDBi48357

PTM databases

iPTMnetiO14981
PhosphoSitePlusiO14981

Expressioni

Gene expression databases

BgeeiENSG00000095564 Expressed in 237 organ(s), highest expression level in epithelial cell of pancreas
CleanExiHS_BTAF1
ExpressionAtlasiO14981 baseline and differential
GenevisibleiO14981 HS

Organism-specific databases

HPAiHPA070682

Interactioni

Subunit structurei

Associates with TBP to form B-TFIID. Binds DRAP1.

Protein-protein interaction databases

BioGridi114506, 53 interactors
IntActiO14981, 19 interactors
MINTiO14981
STRINGi9606.ENSP00000265990

Structurei

3D structure databases

ProteinModelPortaliO14981
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati385 – 422HEAT 1Add BLAST38
Repeati426 – 463HEAT 2Add BLAST38
Repeati513 – 550HEAT 3Add BLAST38
Repeati554 – 596HEAT 4Add BLAST43
Repeati818 – 855HEAT 5Add BLAST38
Repeati872 – 910HEAT 6Add BLAST39
Repeati1102 – 1139HEAT 7Add BLAST38
Repeati1182 – 1219HEAT 8Add BLAST38
Domaini1278 – 1453Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST176
Domaini1636 – 1790Helicase C-terminalPROSITE-ProRule annotationAdd BLAST155

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi191 – 207Nuclear localization signalSequence analysisAdd BLAST17
Motifi1404 – 1407DEGH box4

Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0387 Eukaryota
ENOG410XP4Z LUCA
GeneTreeiENSGT00910000144109
HOGENOMiHOG000210415
HOVERGENiHBG017883
InParanoidiO14981
KOiK15192
OMAiALIFCQM
PhylomeDBiO14981
TreeFamiTF300546

Family and domain databases

CDDicd00079 HELICc, 1 hit
Gene3Di1.25.10.10, 2 hits
3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR022707 DUF3535
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
PfamiView protein in Pfam
PF12054 DUF3535, 1 hit
PF00271 Helicase_C, 1 hit
PF00176 SNF2_N, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O14981-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVSRLDRLF ILLDTGTTPV TRKAAAQQLG EVVKLHPHEL NNLLSKVLIY
60 70 80 90 100
LRSANWDTRI AAGQAVEAIV KNVPEWNPVP RTRQEPTSES SMEDSPTTER
110 120 130 140 150
LNFDRFDICR LLQHGASLLG SAGAEFEVQD EKSGEVDPKE RIARQRKLLQ
160 170 180 190 200
KKLGLNMGEA IGMSTEELFN DEDLDYTPTS ASFVNKQPTL QAAELIDSEF
210 220 230 240 250
RAGMSNRQKN KAKRMAKLFA KQRSRDAVET NEKSNDSTDG EPEEKRRKIA
260 270 280 290 300
NVVINQSAND SKVLIDNIPD SSSLIEETNE WPLESFCEEL CNDLFNPSWE
310 320 330 340 350
VRHGAGTGLR EILKAHGKSG GKMGDSTLEE MIQQHQEWLE DLVIRLLCVF
360 370 380 390 400
ALDRFGDFVS DEVVAPVRET CAQTLGVVLK HMNETGVHKT VDVLLKLLTQ
410 420 430 440 450
EQWEVRHGGL LGIKYALAVR QDVINTLLPK VLTRIIEGLQ DLDDDVRAVA
460 470 480 490 500
AASLVPVVES LVYLQTQKVP FIINTLWDAL LELDDLTAST NSIMTLLSSL
510 520 530 540 550
LTYPQVQQCS IQQSLTVLVP RVWPFLHHTI SSVRRAALET LFTLLSTQDQ
560 570 580 590 600
NSSSWLIPIL PDMLRHIFQF CVLESSQEIL DLIHKVWMEL LSKASVQYVV
610 620 630 640 650
AAACPWMGAW LCLMMQPSHL PIDLNMLLEV KARAKEKTGG KVRQGQSQNK
660 670 680 690 700
EVLQEYIAGA DTIMEDPATR DFVVMRARMM AAKLLGALCC CICDPGVNVV
710 720 730 740 750
TQEIKPAESL GQLLLFHLNS KSALQRISVA LVICEWAALQ KECKAVTLAV
760 770 780 790 800
QPRLLDILSE HLYYDEIAVP FTRMQNECKQ LISSLADVHI EVGNRVNNNV
810 820 830 840 850
LTIDQASDLV TTVFNEATSS FDLNPQVLQQ LDSKRQQVQM TVTETNQEWQ
860 870 880 890 900
VLQLRVHTFA ACAVVSLQQL PEKLNPIIKP LMETIKKEEN TLVQNYAAQC
910 920 930 940 950
IAKLLQQCTT RTPCPNSKII KNLCSSLCVD PYLTPCVTCP VPTQSGQENS
960 970 980 990 1000
KGSTSEKDGM HHTVTKHRGI ITLYRHQKAA FAITSRRGPT PKAVKAQIAD
1010 1020 1030 1040 1050
LPAGSSGNIL VELDEAQKPY LVQRRGAEFA LTTIVKHFGG EMAVKLPHLW
1060 1070 1080 1090 1100
DAMVGPLRNT IDINNFDGKS LLDKGDSPAQ ELVNSLQVFE TAAASMDSEL
1110 1120 1130 1140 1150
HPLLVQHLPH LYMCLQYPST AVRHMAARCV GVMSKIATME TMNIFLEKVL
1160 1170 1180 1190 1200
PWLGAIDDSV KQEGAIEALA CVMEQLDVGI VPYIVLLVVP VLGRMSDQTD
1210 1220 1230 1240 1250
SVRFMATQCF ATLIRLMPLE AGIPDPPNMS AELIQLKAKE RHFLEQLLDG
1260 1270 1280 1290 1300
KKLENYKIPV PINAELRKYQ QDGVNWLAFL NKYKLHGILC DDMGLGKTLQ
1310 1320 1330 1340 1350
SICILAGDHC HRAQEYARSK LAECMPLPSL VVCPPTLTGH WVDEVGKFCS
1360 1370 1380 1390 1400
REYLNPLHYT GPPTERIRLQ HQVKRHNLIV ASYDVVRNDI DFFRNIKFNY
1410 1420 1430 1440 1450
CILDEGHVIK NGKTKLSKAV KQLTANYRII LSGTPIQNNV LELWSLFDFL
1460 1470 1480 1490 1500
MPGFLGTERQ FAARYGKPIL ASRDARSSSR EQEAGVLAMD ALHRQVLPFL
1510 1520 1530 1540 1550
LRRMKEDVLQ DLPPKIIQDY YCTLSPLQVQ LYEDFAKSRA KCDVDETVSS
1560 1570 1580 1590 1600
ATLSEETEKP KLKATGHVFQ ALQYLRKLCN HPALVLTPQH PEFKTTAEKL
1610 1620 1630 1640 1650
AVQNSSLHDI QHAPKLSALK QLLLDCGLGN GSTSESGTES VVAQHRILIF
1660 1670 1680 1690 1700
CQLKSMLDIV EHDLLKPHLP SVTYLRLDGS IPPGQRHSIV SRFNNDPSID
1710 1720 1730 1740 1750
VLLLTTHVGG LGLNLTGADT VVFVEHDWNP MRDLQAMDRA HRIGQKRVVN
1760 1770 1780 1790 1800
VYRLITRGTL EEKIMGLQKF KMNIANTVIS QENSSLQSMG TDQLLDLFTL
1810 1820 1830 1840
DKDGKAEKAD TSTSGKASMK SILENLSDLW DQEQYDSEYS LENFMHSLK
Length:1,849
Mass (Da):206,887
Last modified:August 1, 1998 - v2
Checksum:iFE3675B75A44F113
GO
Isoform 2 (identifier: O14981-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1172: Missing.

Note: No experimental confirmation available.
Show »
Length:677
Mass (Da):76,419
Checksum:iDA3558BDAEF2B0D0
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MTH9A0A0A0MTH9_HUMAN
TATA-binding protein-associated fac...
BTAF1
1,849Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0565101 – 1172Missing in isoform 2. 1 PublicationAdd BLAST1172

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001017 mRNA Translation: CAA04475.1
AF038362 mRNA Translation: AAC04573.1
AK303554 mRNA Translation: BAG64578.1
AL359198 Genomic DNA No translation available.
AL365398 Genomic DNA No translation available.
AF166118 Genomic DNA Translation: AAF37803.1
CCDSiCCDS7419.1 [O14981-1]
RefSeqiNP_003963.1, NM_003972.2 [O14981-1]
UniGeneiHs.500526

Genome annotation databases

EnsembliENST00000265990; ENSP00000265990; ENSG00000095564 [O14981-1]
GeneIDi9044
KEGGihsa:9044

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001017 mRNA Translation: CAA04475.1
AF038362 mRNA Translation: AAC04573.1
AK303554 mRNA Translation: BAG64578.1
AL359198 Genomic DNA No translation available.
AL365398 Genomic DNA No translation available.
AF166118 Genomic DNA Translation: AAF37803.1
CCDSiCCDS7419.1 [O14981-1]
RefSeqiNP_003963.1, NM_003972.2 [O14981-1]
UniGeneiHs.500526

3D structure databases

ProteinModelPortaliO14981
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114506, 53 interactors
IntActiO14981, 19 interactors
MINTiO14981
STRINGi9606.ENSP00000265990

PTM databases

iPTMnetiO14981
PhosphoSitePlusiO14981

Polymorphism and mutation databases

BioMutaiBTAF1

Proteomic databases

EPDiO14981
PaxDbiO14981
PeptideAtlasiO14981
PRIDEiO14981
ProteomicsDBi48357

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265990; ENSP00000265990; ENSG00000095564 [O14981-1]
GeneIDi9044
KEGGihsa:9044

Organism-specific databases

CTDi9044
DisGeNETi9044
EuPathDBiHostDB:ENSG00000095564.13
GeneCardsiBTAF1
HGNCiHGNC:17307 BTAF1
HPAiHPA070682
MIMi605191 gene
neXtProtiNX_O14981
OpenTargetsiENSG00000095564
PharmGKBiPA25437
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0387 Eukaryota
ENOG410XP4Z LUCA
GeneTreeiENSGT00910000144109
HOGENOMiHOG000210415
HOVERGENiHBG017883
InParanoidiO14981
KOiK15192
OMAiALIFCQM
PhylomeDBiO14981
TreeFamiTF300546

Miscellaneous databases

ChiTaRSiBTAF1 human
GeneWikiiBTAF1
GenomeRNAii9044
PROiPR:O14981
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000095564 Expressed in 237 organ(s), highest expression level in epithelial cell of pancreas
CleanExiHS_BTAF1
ExpressionAtlasiO14981 baseline and differential
GenevisibleiO14981 HS

Family and domain databases

CDDicd00079 HELICc, 1 hit
Gene3Di1.25.10.10, 2 hits
3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR022707 DUF3535
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
PfamiView protein in Pfam
PF12054 DUF3535, 1 hit
PF00271 Helicase_C, 1 hit
PF00176 SNF2_N, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBTAF1_HUMAN
AccessioniPrimary (citable) accession number: O14981
Secondary accession number(s): B4E0W6, O43578
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 1, 1998
Last modified: November 7, 2018
This is version 177 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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