Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Exportin-1

Gene

XPO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap.4 Publications
(Microbial infection) Mediates the export of unspliced or incompletely spliced RNAs out of the nucleus from different viruses including HIV-1, HTLV-1 and influenza A. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization.2 Publications

Miscellaneous

Cellular target of leptomycin B (LMB), a XPO1/CRM1 nuclear export inhibitor.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processHost-virus interaction, mRNA transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-165054 Rev-mediated nuclear export of HIV RNA
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery
R-HSA-2173788 Downregulation of TGF-beta receptor signaling
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex
R-HSA-450520 HuR (ELAVL1) binds and stabilizes mRNA
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-5687128 MAPK6/MAPK4 signaling
R-HSA-68877 Mitotic Prometaphase
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition
SignaLinkiO14980
SIGNORiO14980

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Exportin-1
Short name:
Exp1
Alternative name(s):
Chromosome region maintenance 1 protein homolog
Gene namesi
Name:XPO1
Synonyms:CRM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000082898.16
HGNCiHGNC:12825 XPO1
MIMi602559 gene
neXtProtiNX_O14980

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi191S → A: Does not abolish Rex-mediated mRNA export. 1 Publication1
Mutagenesisi284V → E: Does not abolish Rex-mediated mRNA export. 1 Publication1
Mutagenesisi334D → G: Does not abolish Rex-mediated mRNA export. 1 Publication1
Mutagenesisi337I → L: Does not abolish Rex-mediated mRNA export. 1 Publication1
Mutagenesisi346T → A: Does not abolish Rex-mediated mRNA export. 1 Publication1
Mutagenesisi402V → I: Does not abolish Rex-mediated mRNA export. 1 Publication1
Mutagenesisi411P → T: Strongly abolishes interaction with Rex and RANBP3, abolishes Rex-mediated mRNA export. Does not abolish interaction with RANBP3; when associated with S-414. Abolishes Rex multimerization; when associated with S-414. 1 Publication1
Mutagenesisi412M → V: Does not abolish interaction with Rex and RANBP3, and Rex-mediated mRNA export. 1 Publication1
Mutagenesisi414F → S: Strongly abolishes interaction with Rex and RANBP3, abolishes Rex-mediated mRNA export. Does not abolish interaction with RANBP3; when associated with T-411. Abolishes Rex multimerization; when associated with T-411. 1 Publication1
Mutagenesisi428 – 447EEVLV…EFMKD → QQVLVVQNNQGQVVRQFMKN: Abolishes Ran binding activity in absence of cargo and abolishes partially Ran binding activity in presence of cargo. 1 PublicationAdd BLAST20
Mutagenesisi430 – 446VLVVE…REFMK → DEDEENDQGEDEEEDDD: Partially restores Ran binding activity in presence of cargo. 1 PublicationAdd BLAST17
Mutagenesisi430 – 433VLVV → DEDE: Abolishes Ran binding activity both in absence or presence of cargo. 1 Publication4
Mutagenesisi454Y → A: Does not abolish Ran binding activity and nuclear export complex formation. 1 Publication1
Mutagenesisi474R → I: Strongly abolishes interaction with Rex and RANBP3, abolishes Rex-mediated mRNA export. 1 Publication1
Mutagenesisi481H → Q: Strongly abolishes interaction with Rex and RANBP3, abolishes Rex-mediated mRNA export. 1 Publication1
Mutagenesisi513E → A: Abolishes Ran binding activity and nuclear export complex formation. Abolishes Ran binding activity and nuclear export complex formation; when associated with A-553 and A-554. 1 Publication1
Mutagenesisi525L → A: Enhances Ran binding activity and does not abolish nuclear export complex formation. Does not abolish Ran binding activity and partially abolish nuclear export complex formation; when associated with A-561. Does not abolish Ran binding activity and partially abolish nuclear export complex formation; when associated with A-568 and A-572. 1 Publication1
Mutagenesisi550Q → A: Enhances Ran binding activity and does not abolish nuclear export complex formation; when associated with A-553 and A-590. 1 Publication1
Mutagenesisi553R → A: Enhances Ran binding activity and does not abolish nuclear export complex formation; when associated with A-550 and A-590. Abolishes Ran binding activity and nuclear export complex formation; when associated with A-513 and A-554. 1 Publication1
Mutagenesisi554F → A: Partially abolishes Ran binding activity and does not abolish nuclear export complex formation. Abolishes Ran binding activity and nuclear export complex formation; when associated with A-561. Abolishes Ran binding activity and nuclear export complex formation; when associated with A-553 and A-513. 1 Publication1
Mutagenesisi561F → A: Abolishes Ran binding activity and nuclear export complex formation. Abolishes Ran binding activity and nuclear export complex formation; when associated with A-554. Does not abolish Ran binding activity and partially abolish nuclear export complex formation; when associated with A-525. 1 Publication1
Mutagenesisi568K → A: Does not abolish Ran binding activity and partially abolish nuclear export complex formation; when associated with A-525 and A-572. 1 Publication1
Mutagenesisi572F → A: Does not abolish Ran binding activity and partially abolish nuclear export complex formation; when associated with A-525 and A-568. 1 Publication1
Mutagenesisi583M → A: Enhances Ran binding activity; when associated with A-590. 1 Publication1
Mutagenesisi590K → A: Enhances Ran binding activity and does not abolish nuclear export complex formation. Enhances Ran binding activity and does not abolish nuclear export complex formation; when associated with A-583. Enhances Ran binding activity and does not abolish nuclear export complex formation; when associated with A-550 and A-553. 1 Publication1

Organism-specific databases

DisGeNETi7514
OpenTargetsiENSG00000082898
PharmGKBiPA37418

Chemistry databases

ChEMBLiCHEMBL5661

Polymorphism and mutation databases

BioMutaiXPO1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002047051 – 1071Exportin-1Add BLAST1071

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei391PhosphoserineCombined sources1
Modified residuei446N6-acetyllysineCombined sources1
Modified residuei448PhosphothreonineBy similarity1
Modified residuei450PhosphoserineBy similarity1
Modified residuei454PhosphotyrosineBy similarity1
Modified residuei693N6-acetyllysineCombined sources1
Modified residuei1031PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO14980
MaxQBiO14980
PaxDbiO14980
PeptideAtlasiO14980
PRIDEiO14980
ProteomicsDBi48356

PTM databases

iPTMnetiO14980
PhosphoSitePlusiO14980
SwissPalmiO14980

Expressioni

Tissue specificityi

Expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. Not expressed in the kidney.2 Publications

Gene expression databases

BgeeiENSG00000082898 Expressed in 241 organ(s), highest expression level in female gonad
CleanExiHS_XPO1
ExpressionAtlasiO14980 baseline and differential
GenevisibleiO14980 HS

Organism-specific databases

HPAiCAB010184
HPA042933

Interactioni

Subunit structurei

Found in a U snRNA export complex with PHAX/RNUXA, NCBP1/CBP80, NCBP2/CBP20, RAN, XPO1 and m7G-capped RNA (By similarity). Component of a nuclear export receptor complex composed of KPNB1, RAN, SNUPN and XPO1. Found in a trimeric export complex with SNUPN, RAN and XPO1. Found in a nuclear export complex with RANBP3 and RAN. Found in a 60S ribosomal subunit export complex with NMD3, RAN, XPO1. Interacts with DDX3X, NMD3, NUPL2, NUP88, NUP214, RANBP3 and TERT. Interacts with NEMF (via its N-terminus). Interacts with the monomeric form of BIRC5/survivin deacetylated at 'Lys-129'. Interacts with DTNBP1 and SERTAD2; the interactions translocate DTNBP1 and SERTAD2 out of the nucleus. Interacts with ATF2. Interacts with SLC35G1 and STIM1. Interacts with DCAF8. Interacts with CPEB3 (PubMed:22730302). Interacts with HAX1 (PubMed:23164465). Interacts with BOK; translocates to the cytoplasm (PubMed:16302269). Interacts with HSP90AB1 (PubMed:22022502).By similarity23 Publications
(Microbial infection) Interacts with HIV-1 Rev.3 Publications
(Microbial infection) Interacts with HTLV-1 Rex.1 Publication
(Microbial infection) Interacts with influenza A nucleoprotein.1 Publication
(Microbial infection) Interacts with Epstein-Barr virus protein BMLF1.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113348, 1236 interactors
CORUMiO14980
DIPiDIP-33678N
IntActiO14980, 74 interactors
MINTiO14980
STRINGi9606.ENSP00000384863

Chemistry databases

BindingDBiO14980

Structurei

Secondary structure

11071
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO14980
SMRiO14980
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO14980

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 112Importin N-terminalPROSITE-ProRule annotationAdd BLAST67
Repeati217 – 240HEAT 1Add BLAST24
Repeati241 – 277HEAT 2Add BLAST37
Repeati354 – 472HEAT 3Add BLAST119
Repeati515 – 553HEAT 4Add BLAST39
Repeati560 – 597HEAT 5Add BLAST38
Repeati602 – 639HEAT 6Add BLAST38
Repeati775 – 813HEAT 7Add BLAST39
Repeati885 – 916HEAT 8Add BLAST32
Repeati917 – 954HEAT 9Add BLAST38
Repeati1002 – 1039HEAT 10Add BLAST38

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 679Necessary for HTLV-1 Rex-mediated mRNA exportAdd BLAST679
Regioni327 – 450Interaction with Ran and nuclear export complex formationAdd BLAST124
Regioni411 – 481Interaction with RANBP3Add BLAST71
Regioni411 – 414Necessary for HTLV-1 Rex multimerization4
Regioni800 – 820Interaction with HIV-1 RevAdd BLAST21

Sequence similaritiesi

Belongs to the exportin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2020 Eukaryota
COG5101 LUCA
GeneTreeiENSGT00390000000572
HOVERGENiHBG052817
InParanoidiO14980
KOiK14290
OMAiCENNMII
OrthoDBiEOG091G013G
PhylomeDBiO14980
TreeFamiTF105695

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR014877 CRM1_C_dom
IPR013598 Exportin-1/Importin-b-like
IPR001494 Importin-beta_N
PfamiView protein in Pfam
PF08767 CRM1_C, 1 hit
PF03810 IBN_N, 1 hit
PF08389 Xpo1, 1 hit
SMARTiView protein in SMART
SM01102 CRM1_C, 1 hit
SM00913 IBN_N, 1 hit
SUPFAMiSSF48371 SSF48371, 4 hits
PROSITEiView protein in PROSITE
PS50166 IMPORTIN_B_NT, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

O14980-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPAIMTMLAD HAARQLLDFS QKLDINLLDN VVNCLYHGEG AQQRMAQEVL
60 70 80 90 100
THLKEHPDAW TRVDTILEFS QNMNTKYYGL QILENVIKTR WKILPRNQCE
110 120 130 140 150
GIKKYVVGLI IKTSSDPTCV EKEKVYIGKL NMILVQILKQ EWPKHWPTFI
160 170 180 190 200
SDIVGASRTS ESLCQNNMVI LKLLSEEVFD FSSGQITQVK SKHLKDSMCN
210 220 230 240 250
EFSQIFQLCQ FVMENSQNAP LVHATLETLL RFLNWIPLGY IFETKLISTL
260 270 280 290 300
IYKFLNVPMF RNVSLKCLTE IAGVSVSQYE EQFVTLFTLT MMQLKQMLPL
310 320 330 340 350
NTNIRLAYSN GKDDEQNFIQ NLSLFLCTFL KEHDQLIEKR LNLRETLMEA
360 370 380 390 400
LHYMLLVSEV EETEIFKICL EYWNHLAAEL YRESPFSTSA SPLLSGSQHF
410 420 430 440 450
DVPPRRQLYL PMLFKVRLLM VSRMAKPEEV LVVENDQGEV VREFMKDTDS
460 470 480 490 500
INLYKNMRET LVYLTHLDYV DTERIMTEKL HNQVNGTEWS WKNLNTLCWA
510 520 530 540 550
IGSISGAMHE EDEKRFLVTV IKDLLGLCEQ KRGKDNKAII ASNIMYIVGQ
560 570 580 590 600
YPRFLRAHWK FLKTVVNKLF EFMHETHDGV QDMACDTFIK IAQKCRRHFV
610 620 630 640 650
QVQVGEVMPF IDEILNNINT IICDLQPQQV HTFYEAVGYM IGAQTDQTVQ
660 670 680 690 700
EHLIEKYMLL PNQVWDSIIQ QATKNVDILK DPETVKQLGS ILKTNVRACK
710 720 730 740 750
AVGHPFVIQL GRIYLDMLNV YKCLSENISA AIQANGEMVT KQPLIRSMRT
760 770 780 790 800
VKRETLKLIS GWVSRSNDPQ MVAENFVPPL LDAVLIDYQR NVPAAREPEV
810 820 830 840 850
LSTMAIIVNK LGGHITAEIP QIFDAVFECT LNMINKDFEE YPEHRTNFFL
860 870 880 890 900
LLQAVNSHCF PAFLAIPPTQ FKLVLDSIIW AFKHTMRNVA DTGLQILFTL
910 920 930 940 950
LQNVAQEEAA AQSFYQTYFC DILQHIFSVV TDTSHTAGLT MHASILAYMF
960 970 980 990 1000
NLVEEGKIST SLNPGNPVNN QIFLQEYVAN LLKSAFPHLQ DAQVKLFVTG
1010 1020 1030 1040 1050
LFSLNQDIPA FKEHLRDFLV QIKEFAGEDT SDLFLEEREI ALRQADEEKH
1060 1070
KRQMSVPGIF NPHEIPEEMC D
Length:1,071
Mass (Da):123,386
Last modified:January 1, 1998 - v1
Checksum:iFDB00C065DA2FB1D
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JKM9C9JKM9_HUMAN
Exportin-1
XPO1
179Annotation score:
C9J673C9J673_HUMAN
Exportin-1
XPO1
132Annotation score:
H7BZC5H7BZC5_HUMAN
Exportin-1
XPO1
72Annotation score:
C9JV99C9JV99_HUMAN
Exportin-1
XPO1
100Annotation score:
C9JQ02C9JQ02_HUMAN
Exportin-1
XPO1
95Annotation score:
C9IZS4C9IZS4_HUMAN
Exportin-1
XPO1
94Annotation score:
C9JF49C9JF49_HUMAN
Exportin-1
XPO1
59Annotation score:
F8WF71F8WF71_HUMAN
Exportin-1
XPO1
82Annotation score:
C9IYM2C9IYM2_HUMAN
Exportin-1
XPO1
62Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti406R → G in CAH56174 (PubMed:17974005).Curated1
Sequence conflicti953V → G in CAH18695 (PubMed:17974005).Curated1
Sequence conflicti989L → I in CAH56174 (PubMed:17974005).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08614 mRNA Translation: CAA69905.2
D89729 mRNA Translation: BAA23415.1
AK289920 mRNA Translation: BAF82609.1
BX647758 mRNA Translation: CAH56174.1
CR749840 mRNA Translation: CAH18695.1
AC016727 Genomic DNA Translation: AAY14949.1
CH471053 Genomic DNA Translation: EAW99993.1
CH471053 Genomic DNA Translation: EAW99994.1
BC032847 mRNA Translation: AAH32847.1
CCDSiCCDS33205.1
RefSeqiNP_003391.1, NM_003400.3
XP_006712157.1, XM_006712094.2
XP_011531399.1, XM_011533097.1
UniGeneiHs.370770

Genome annotation databases

EnsembliENST00000401558; ENSP00000384863; ENSG00000082898
ENST00000404992; ENSP00000385942; ENSG00000082898
ENST00000406957; ENSP00000385559; ENSG00000082898
GeneIDi7514
KEGGihsa:7514
UCSCiuc002sbj.4 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08614 mRNA Translation: CAA69905.2
D89729 mRNA Translation: BAA23415.1
AK289920 mRNA Translation: BAF82609.1
BX647758 mRNA Translation: CAH56174.1
CR749840 mRNA Translation: CAH18695.1
AC016727 Genomic DNA Translation: AAY14949.1
CH471053 Genomic DNA Translation: EAW99993.1
CH471053 Genomic DNA Translation: EAW99994.1
BC032847 mRNA Translation: AAH32847.1
CCDSiCCDS33205.1
RefSeqiNP_003391.1, NM_003400.3
XP_006712157.1, XM_006712094.2
XP_011531399.1, XM_011533097.1
UniGeneiHs.370770

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1W9CX-ray2.30A/B707-1027[»]
2L1LNMR-B504-630[»]
3GB8X-ray2.90A1-1071[»]
4BSMX-ray4.50A1-1032[»]
4BSNX-ray4.10A1-1032[»]
5DISX-ray2.85A5-1048[»]
ProteinModelPortaliO14980
SMRiO14980
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113348, 1236 interactors
CORUMiO14980
DIPiDIP-33678N
IntActiO14980, 74 interactors
MINTiO14980
STRINGi9606.ENSP00000384863

Chemistry databases

BindingDBiO14980
ChEMBLiCHEMBL5661

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

PTM databases

iPTMnetiO14980
PhosphoSitePlusiO14980
SwissPalmiO14980

Polymorphism and mutation databases

BioMutaiXPO1

Proteomic databases

EPDiO14980
MaxQBiO14980
PaxDbiO14980
PeptideAtlasiO14980
PRIDEiO14980
ProteomicsDBi48356

Protocols and materials databases

DNASUi7514
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000401558; ENSP00000384863; ENSG00000082898
ENST00000404992; ENSP00000385942; ENSG00000082898
ENST00000406957; ENSP00000385559; ENSG00000082898
GeneIDi7514
KEGGihsa:7514
UCSCiuc002sbj.4 human

Organism-specific databases

CTDi7514
DisGeNETi7514
EuPathDBiHostDB:ENSG00000082898.16
GeneCardsiXPO1
HGNCiHGNC:12825 XPO1
HPAiCAB010184
HPA042933
MIMi602559 gene
neXtProtiNX_O14980
OpenTargetsiENSG00000082898
PharmGKBiPA37418
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2020 Eukaryota
COG5101 LUCA
GeneTreeiENSGT00390000000572
HOVERGENiHBG052817
InParanoidiO14980
KOiK14290
OMAiCENNMII
OrthoDBiEOG091G013G
PhylomeDBiO14980
TreeFamiTF105695

Enzyme and pathway databases

ReactomeiR-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-165054 Rev-mediated nuclear export of HIV RNA
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery
R-HSA-2173788 Downregulation of TGF-beta receptor signaling
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex
R-HSA-450520 HuR (ELAVL1) binds and stabilizes mRNA
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-5687128 MAPK6/MAPK4 signaling
R-HSA-68877 Mitotic Prometaphase
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition
SignaLinkiO14980
SIGNORiO14980

Miscellaneous databases

ChiTaRSiXPO1 human
EvolutionaryTraceiO14980
GeneWikiiXPO1
GenomeRNAii7514
PROiPR:O14980
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000082898 Expressed in 241 organ(s), highest expression level in female gonad
CleanExiHS_XPO1
ExpressionAtlasiO14980 baseline and differential
GenevisibleiO14980 HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR014877 CRM1_C_dom
IPR013598 Exportin-1/Importin-b-like
IPR001494 Importin-beta_N
PfamiView protein in Pfam
PF08767 CRM1_C, 1 hit
PF03810 IBN_N, 1 hit
PF08389 Xpo1, 1 hit
SMARTiView protein in SMART
SM01102 CRM1_C, 1 hit
SM00913 IBN_N, 1 hit
SUPFAMiSSF48371 SSF48371, 4 hits
PROSITEiView protein in PROSITE
PS50166 IMPORTIN_B_NT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiXPO1_HUMAN
AccessioniPrimary (citable) accession number: O14980
Secondary accession number(s): A6NL14
, A8K1K5, D6W5E2, Q63HP8, Q68CP3, Q99433
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: January 1, 1998
Last modified: October 10, 2018
This is version 186 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again