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Entry version 173 (13 Feb 2019)
Sequence version 3 (01 Aug 1999)
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Protein

Heterogeneous nuclear ribonucleoprotein D-like

Gene

HNRNPDL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes (By similarity). Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter (By similarity). Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • double-stranded DNA binding Source: UniProtKB
  • poly(A) binding Source: UniProtKB
  • poly(G) binding Source: UniProtKB
  • RNA binding Source: UniProtKB
  • sequence-specific DNA binding Source: GO_Central
  • sequence-specific double-stranded DNA binding Source: GO_Central
  • single-stranded DNA binding Source: UniProtKB

GO - Biological processi

  • interleukin-12-mediated signaling pathway Source: Reactome
  • regulation of gene expression Source: UniProtKB
  • RNA processing Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Repressor, RNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein D-like
Short name:
hnRNP D-like
Short name:
hnRNP DL
Alternative name(s):
AU-rich element RNA-binding factor
JKT41-binding protein
Protein laAUF1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HNRNPDL
Synonyms:HNRPDL, JKTBP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000152795.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:5037 HNRNPDL

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607137 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O14979

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Muscular dystrophy, limb-girdle, autosomal dominant 3 (LGMDD3)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant degenerative myopathy characterized by slowly progressive wasting and weakness of the proximal muscles of arms and legs around the pelvic or shoulder girdles, elevated creatine kinase levels and dystrophic features on muscle biopsy. LGMDD3 is characterized by a mild late-onset and is associated with progressive fingers and toes flexion limitation. Affected individuals may also develop cataracts before age 50.
See also OMIM:609115
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_072567378D → H in LGMDD3. 1 PublicationCorresponds to variant dbSNP:rs587777669EnsemblClinVar.1
Natural variantiVAR_072568378D → N in LGMDD3. 1 PublicationCorresponds to variant dbSNP:rs587777669EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi404G → A: Reduces significantly its nuclear localization. 1 Publication1

Keywords - Diseasei

Disease mutation, Limb-girdle muscular dystrophy

Organism-specific databases

DisGeNET

More...
DisGeNETi
9987

MalaCards human disease database

More...
MalaCardsi
HNRNPDL
MIMi609115 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000152795

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
55596 Autosomal dominant limb-girdle muscular dystrophy type 1G

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29362

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HNRNPDL

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002872391 – 420Heterogeneous nuclear ribonucleoprotein D-likeAdd BLAST420

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei25Omega-N-methylarginineCombined sources1
Modified residuei161N6-methyllysine1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki209Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei216N6-acetyllysineCombined sources1
Modified residuei241PhosphoserineCombined sources1
Modified residuei408Dimethylated arginine; alternate1 Publication1
Modified residuei408Omega-N-methylarginine; alternateBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Dimethylation of Arg-408 is probably of the asymmetric type.

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O14979

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O14979

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O14979

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O14979

PeptideAtlas

More...
PeptideAtlasi
O14979

PRoteomics IDEntifications database

More...
PRIDEi
O14979

ProteomicsDB human proteome resource

More...
ProteomicsDBi
48353
48354 [O14979-2]
48355 [O14979-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O14979

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O14979

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O14979

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes. Expressed in myeloid leukemia, gastric adenocarcinoma, cervical carcinoma, hepatoma, fibrosarcoma, colon adenocarcinoma, epidermoid carcinoma, osteosarcoma and urinary bladder carcinoma cells.2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by 12-O-tetradecanoylphorbol-13-acetate (TPA) in macrophages and retinoic acid (RA) in granulocytes (at protein level). Down-regulated by IL4/interleukin-4.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000152795 Expressed in 233 organ(s), highest expression level in substantia nigra

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O14979 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O14979 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA056820
HPA063147

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ZNF148 (By similarity). Interacts with TNPO1.By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
SF1Q156374EBI-299727,EBI-744603

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115308, 132 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
O14979

Protein interaction database and analysis system

More...
IntActi
O14979, 69 interactors

Molecular INTeraction database

More...
MINTi
O14979

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000295470

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O14979

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O14979

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini148 – 230RRM 1PROSITE-ProRule annotationAdd BLAST83
Domaini233 – 312RRM 2PROSITE-ProRule annotationAdd BLAST80

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni342 – 420Necessary for interaction with TNPO11 PublicationAdd BLAST79
Regioni396 – 420Necessary for its nuclear import and exportAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi79 – 82Poly-Arg4
Compositional biasi316 – 321Poly-Gln6
Compositional biasi323 – 411Gly-richAdd BLAST89
Compositional biasi353 – 396Tyr-richAdd BLAST44

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IQWX Eukaryota
ENOG4111SPT LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154426

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234441

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG002295

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O14979

KEGG Orthology (KO)

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KOi
K13044

Identification of Orthologs from Complete Genome Data

More...
OMAi
GPGYTDY

Database of Orthologous Groups

More...
OrthoDBi
1565323at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O14979

TreeFam database of animal gene trees

More...
TreeFami
TF314808

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12758 RRM1_hnRPDL, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR034847 hnRPDL_RRM1
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00076 RRM_1, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00360 RRM, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928 SSF54928, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102 RRM, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O14979-1) [UniParc]FASTAAdd to basket
Also known as: JKTBP1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEVPPRLSHV PPPLFPSAPA TLASRSLSHW RPRPPRQLAP LLPSLAPSSA
60 70 80 90 100
RQGARRAQRH VTAQQPSRLA GGAAIKGGRR RRPDLFRRHF KSSSIQRSAA
110 120 130 140 150
AAAATRTARQ HPPADSSVTM EDMNEYSNIE EFAEGSKINA SKNQQDDGKM
160 170 180 190 200
FIGGLSWDTS KKDLTEYLSR FGEVVDCTIK TDPVTGRSRG FGFVLFKDAA
210 220 230 240 250
SVDKVLELKE HKLDGKLIDP KRAKALKGKE PPKKVFVGGL SPDTSEEQIK
260 270 280 290 300
EYFGAFGEIE NIELPMDTKT NERRGFCFIT YTDEEPVKKL LESRYHQIGS
310 320 330 340 350
GKCEIKVAQP KEVYRQQQQQ QKGGRGAAAG GRGGTRGRGR GQGQNWNQGF
360 370 380 390 400
NNYYDQGYGN YNSAYGGDQN YSGYGGYDYT GYNYGNYGYG QGYADYSGQQ
410 420
STYGKASRGG GNHQNNYQPY
Length:420
Mass (Da):46,438
Last modified:August 1, 1999 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i00F631863859D0CA
GO
Isoform 2 (identifier: O14979-2) [UniParc]FASTAAdd to basket
Also known as: JKTBP2

The sequence of this isoform differs from the canonical sequence as follows:
     1-119: Missing.

Show »
Length:301
Mass (Da):33,589
Checksum:i6BF76C3AEB682BAD
GO
Isoform 3 (identifier: O14979-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-119: Missing.
     341-397: Missing.

Show »
Length:244
Mass (Da):27,191
Checksum:i977B204371D65D76
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WUK2A0A087WUK2_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPDL HNRPDL, hCG_22986
363Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WU03A0A087WU03_HUMAN
Heterogeneous nuclear ribonucleopro...
HNRNPDL
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA22860 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_072567378D → H in LGMDD3. 1 PublicationCorresponds to variant dbSNP:rs587777669EnsemblClinVar.1
Natural variantiVAR_072568378D → N in LGMDD3. 1 PublicationCorresponds to variant dbSNP:rs587777669EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0254101 – 119Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST119
Alternative sequenceiVSP_025411341 – 397Missing in isoform 3. 1 PublicationAdd BLAST57

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB017019 mRNA Translation: BAA75241.1
D89092 mRNA Translation: BAA24361.1
AB066484 mRNA Translation: BAB62188.1
CR407623 mRNA Translation: CAG28551.1
AC124016 Genomic DNA Translation: AAY40914.1
AB017018 Genomic DNA Translation: BAA75239.1
AB017018 Genomic DNA Translation: BAA75240.1
BC007392 mRNA Translation: AAH07392.2
BC011714 mRNA Translation: AAH11714.1
BC071944 mRNA Translation: AAH71944.1
AY453824 mRNA Translation: AAR17782.1
D89678 mRNA Translation: BAA22860.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS3593.1 [O14979-1]

Protein sequence database of the Protein Information Resource

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PIRi
JW0079

NCBI Reference Sequences

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RefSeqi
NP_001193929.1, NM_001207000.1
NP_112740.1, NM_031372.3 [O14979-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.527105
Hs.707013

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000295470; ENSP00000295470; ENSG00000152795 [O14979-1]
ENST00000349655; ENSP00000338552; ENSG00000152795 [O14979-2]
ENST00000502762; ENSP00000422040; ENSG00000152795 [O14979-1]
ENST00000507721; ENSP00000480156; ENSG00000152795 [O14979-2]
ENST00000602300; ENSP00000473677; ENSG00000152795 [O14979-2]
ENST00000621267; ENSP00000483254; ENSG00000152795 [O14979-1]
ENST00000630114; ENSP00000486452; ENSG00000152795 [O14979-2]
ENST00000630827; ENSP00000485954; ENSG00000152795 [O14979-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9987

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9987

UCSC genome browser

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UCSCi
uc003hmr.4 human [O14979-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017019 mRNA Translation: BAA75241.1
D89092 mRNA Translation: BAA24361.1
AB066484 mRNA Translation: BAB62188.1
CR407623 mRNA Translation: CAG28551.1
AC124016 Genomic DNA Translation: AAY40914.1
AB017018 Genomic DNA Translation: BAA75239.1
AB017018 Genomic DNA Translation: BAA75240.1
BC007392 mRNA Translation: AAH07392.2
BC011714 mRNA Translation: AAH11714.1
BC071944 mRNA Translation: AAH71944.1
AY453824 mRNA Translation: AAR17782.1
D89678 mRNA Translation: BAA22860.1 Different initiation.
CCDSiCCDS3593.1 [O14979-1]
PIRiJW0079
RefSeqiNP_001193929.1, NM_001207000.1
NP_112740.1, NM_031372.3 [O14979-1]
UniGeneiHs.527105
Hs.707013

3D structure databases

ProteinModelPortaliO14979
SMRiO14979
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115308, 132 interactors
CORUMiO14979
IntActiO14979, 69 interactors
MINTiO14979
STRINGi9606.ENSP00000295470

PTM databases

iPTMnetiO14979
PhosphoSitePlusiO14979
SwissPalmiO14979

Polymorphism and mutation databases

BioMutaiHNRNPDL

Proteomic databases

EPDiO14979
jPOSTiO14979
MaxQBiO14979
PaxDbiO14979
PeptideAtlasiO14979
PRIDEiO14979
ProteomicsDBi48353
48354 [O14979-2]
48355 [O14979-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
9987
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295470; ENSP00000295470; ENSG00000152795 [O14979-1]
ENST00000349655; ENSP00000338552; ENSG00000152795 [O14979-2]
ENST00000502762; ENSP00000422040; ENSG00000152795 [O14979-1]
ENST00000507721; ENSP00000480156; ENSG00000152795 [O14979-2]
ENST00000602300; ENSP00000473677; ENSG00000152795 [O14979-2]
ENST00000621267; ENSP00000483254; ENSG00000152795 [O14979-1]
ENST00000630114; ENSP00000486452; ENSG00000152795 [O14979-2]
ENST00000630827; ENSP00000485954; ENSG00000152795 [O14979-2]
GeneIDi9987
KEGGihsa:9987
UCSCiuc003hmr.4 human [O14979-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9987
DisGeNETi9987
EuPathDBiHostDB:ENSG00000152795.17

GeneCards: human genes, protein and diseases

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GeneCardsi
HNRNPDL
HGNCiHGNC:5037 HNRNPDL
HPAiHPA056820
HPA063147
MalaCardsiHNRNPDL
MIMi607137 gene
609115 phenotype
neXtProtiNX_O14979
OpenTargetsiENSG00000152795
Orphaneti55596 Autosomal dominant limb-girdle muscular dystrophy type 1G
PharmGKBiPA29362

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IQWX Eukaryota
ENOG4111SPT LUCA
GeneTreeiENSGT00940000154426
HOGENOMiHOG000234441
HOVERGENiHBG002295
InParanoidiO14979
KOiK13044
OMAiGPGYTDY
OrthoDBi1565323at2759
PhylomeDBiO14979
TreeFamiTF314808

Enzyme and pathway databases

ReactomeiR-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
HNRNPDL human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
HNRPDL

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9987

Protein Ontology

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PROi
PR:O14979

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000152795 Expressed in 233 organ(s), highest expression level in substantia nigra
ExpressionAtlasiO14979 baseline and differential
GenevisibleiO14979 HS

Family and domain databases

CDDicd12758 RRM1_hnRPDL, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR034847 hnRPDL_RRM1
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHNRDL_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O14979
Secondary accession number(s): Q6SPF2
, Q7KZ74, Q7KZ75, Q96IM0, Q96S43
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: August 1, 1999
Last modified: February 13, 2019
This is version 173 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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