UniProtKB - O14978 (ZN263_HUMAN)
Zinc finger protein 263
ZNF263
Functioni
Transcription factor that binds to the consensus sequence 5'-TCCTCCC-3' and acts as a transcriptional repressor (PubMed:32051553).
Binds to the promoter region of SIX3 and recruits other proteins involved in chromatin modification and transcriptional corepression, resulting in methylation of the promoter and transcriptional repression (PubMed:32051553).
Acts as transcriptional repressor of HS3ST1 and HS3ST3A1 via binding to gene promoter regions (PubMed:32277030).
2 PublicationsMiscellaneous
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 378 – 400 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 434 – 456 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 462 – 484 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 490 – 512 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 518 – 540 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 575 – 597 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 603 – 625 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 631 – 653 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 659 – 681 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: ProtInc
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SB
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: NTNU_SB
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
- transcription cis-regulatory region binding Source: UniProtKB
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- regulation of transcription, DNA-templated Source: ProtInc
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | O14978 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
SignaLinki | O14978 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 263ImportedAlternative name(s): Zinc finger protein FPM315Imported Zinc finger protein with KRAB and SCAN domains 12Imported |
Gene namesi | |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13056, ZNF263 |
MIMi | 604191, gene |
neXtProti | NX_O14978 |
VEuPathDBi | HostDB:ENSG00000006194 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 10127 |
OpenTargetsi | ENSG00000006194 |
PharmGKBi | PA37634 |
Miscellaneous databases
Pharosi | O14978, Tbio |
Genetic variation databases
BioMutai | ZNF263 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047491 | 1 – 683 | Zinc finger protein 263Add BLAST | 683 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 17 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 157 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 166 | PhosphoserineCombined sources | 1 | |
Modified residuei | 178 | PhosphoserineCombined sources | 1 | |
Cross-linki | 285 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 299 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 376 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 573 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 582 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Post-translational modificationi
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | O14978 |
jPOSTi | O14978 |
MassIVEi | O14978 |
MaxQBi | O14978 |
PaxDbi | O14978 |
PeptideAtlasi | O14978 |
PRIDEi | O14978 |
PTM databases
iPTMneti | O14978 |
PhosphoSitePlusi | O14978 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000006194, Expressed in calcaneal tendon and 232 other tissues |
ExpressionAtlasi | O14978, baseline and differential |
Genevisiblei | O14978, HS |
Organism-specific databases
HPAi | ENSG00000006194, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with a number of proteins involved in chromatin modification and transcriptional corepression including DNMT1, DNMT3A, HDAC2, PHF8, TRIM28/KAP1, SETDB1, EZH2, UHRF1, CBX3/HP1-gamma, and CBX5/HP1-alpha; recruits these proteins to the SIX3 promoter region, leading to SIX3 transcriptional repression (PubMed:32051553).
Interacts with MAPK3/ERK1 and MAPK1/ERK2 (PubMed:32051553).
1 PublicationBinary interactionsi
O14978
Protein-protein interaction databases
BioGRIDi | 115431, 147 interactors |
IntActi | O14978, 74 interactors |
STRINGi | 9606.ENSP00000219069 |
Miscellaneous databases
RNActi | O14978, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 41 – 123 | SCAN boxPROSITE-ProRule annotationAdd BLAST | 83 | |
Domaini | 217 – 289 | KRABPROSITE-ProRule annotationAdd BLAST | 73 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 147 – 185 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 230 – 301 | DisorderedSequence analysisAdd BLAST | 72 | |
Regioni | 322 – 368 | DisorderedSequence analysisAdd BLAST | 47 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 246 – 269 | Polar residuesSequence analysisAdd BLAST | 24 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 378 – 400 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 434 – 456 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 462 – 484 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 490 – 512 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 518 – 540 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 575 – 597 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 603 – 625 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 631 – 653 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 659 – 681 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000159965 |
HOGENOMi | CLU_002678_49_8_1 |
InParanoidi | O14978 |
OMAi | NVEDKEM |
PhylomeDBi | O14978 |
TreeFami | TF350829 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR003309, SCAN_dom IPR038269, SCAN_sf IPR030752, ZNF263 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR23226:SF224, PTHR23226:SF224, 1 hit |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF02023, SCAN, 1 hit PF00096, zf-C2H2, 9 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 9 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 6 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 9 hits PS50157, ZINC_FINGER_C2H2_2, 9 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MASGPGSQER EGLLIVKLEE DCAWSQELPP PDPGPSPEAS HLRFRRFRFQ
60 70 80 90 100
EAAGPREALS RLQELCHGWL RPEMRTKEQI LELLVLEQFL TILPQEIQSR
110 120 130 140 150
VQELHPESGE EAVTLVEDMQ RELGRLRQQV TNHGRGTEVL LEEPLPLETA
160 170 180 190 200
RESPSFKLEP METERSPGPR LQELLGPSPQ RDPQAVKERA LSAPWLSLFP
210 220 230 240 250
PEGNMEDKEM TGPQLPESLE DVAMYISQEE WGHQDPSKRA LSRDTVQESY
260 270 280 290 300
ENVDSLESHI PSQEVPGTQV GQGGKLWDPS VQSCKEGLSP RGPAPGEEKF
310 320 330 340 350
ENLEGVPSVC SENIHPQVLL PDQARGEVPW SPELGRPHDR SQGDWAPPPE
360 370 380 390 400
GGMEQALAGA SSGRELGRPK ELQPKKLHLC PLCGKNFSNN SNLIRHQRIH
410 420 430 440 450
AAERLCMGVD CTEIFGGNPR FLSLHRAHLG EEAHKCLECG KCFSQNTHLT
460 470 480 490 500
RHQRTHTGEK PYQCNICGKC FSCNSNLHRH QRTHTGEKPY KCPECGEIFA
510 520 530 540 550
HSSNLLRHQR IHTGERPYKC PECGKSFSRS SHLVIHERTH ERERLYPFSE
560 570 580 590 600
CGEAVSDSTP FLTNHGAHKA EKKLFECLTC GKSFRQGMHL TRHQRTHTGE
610 620 630 640 650
KPYKCTLCGE NFSHRSNLIR HQRIHTGEKP YTCHECGDSF SHSSNRIRHL
660 670 680
RTHTGERPYK CSECGESFSR SSRLMSHQRT HTG
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketI3NI39 | I3NI39_HUMAN | Zinc finger protein 263 | ZNF263 | 141 | Annotation score: | ||
I3L2X3 | I3L2X3_HUMAN | Zinc finger protein 263 | ZNF263 | 226 | Annotation score: | ||
I3L393 | I3L393_HUMAN | Zinc finger protein 263 | ZNF263 | 149 | Annotation score: | ||
I3L0N0 | I3L0N0_HUMAN | Zinc finger protein 263 | ZNF263 | 115 | Annotation score: | ||
I3L538 | I3L538_HUMAN | Zinc finger protein 263 | ZNF263 | 51 | Annotation score: | ||
I3L4C4 | I3L4C4_HUMAN | Zinc finger protein 263 | ZNF263 | 115 | Annotation score: | ||
B4DI05 | B4DI05_HUMAN | Zinc finger protein 263 | ZNF263 | 331 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 118 | D → G in BAA21853 (PubMed:9256059).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052801 | 310 | C → S. Corresponds to variant dbSNP:rs220379Ensembl. | 1 | |
Natural variantiVAR_052802 | 534 | V → I. Corresponds to variant dbSNP:rs34236132Ensembl. | 1 | |
Natural variantiVAR_061943 | 646 | R → Q. Corresponds to variant dbSNP:rs57710602Ensembl. | 1 | |
Natural variantiVAR_084704 | 646 | R → W Found in a patient with hypothalamic hamartoma; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs747714553Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D88827 mRNA Translation: BAA21853.1 AK312421 mRNA Translation: BAG35331.1 AC004232 Genomic DNA Translation: AAC24490.1 CH471112 Genomic DNA Translation: EAW85379.1 BC008805 mRNA Translation: AAH08805.1 |
CCDSi | CCDS10499.1 |
RefSeqi | NP_005732.2, NM_005741.4 |
Genome annotation databases
Ensembli | ENST00000219069.6; ENSP00000219069.5; ENSG00000006194.10 |
GeneIDi | 10127 |
KEGGi | hsa:10127 |
MANE-Selecti | ENST00000219069.6; ENSP00000219069.5; NM_005741.5; NP_005732.2 |
UCSCi | uc002cuq.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D88827 mRNA Translation: BAA21853.1 AK312421 mRNA Translation: BAG35331.1 AC004232 Genomic DNA Translation: AAC24490.1 CH471112 Genomic DNA Translation: EAW85379.1 BC008805 mRNA Translation: AAH08805.1 |
CCDSi | CCDS10499.1 |
RefSeqi | NP_005732.2, NM_005741.4 |
3D structure databases
AlphaFoldDBi | O14978 |
SMRi | O14978 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 115431, 147 interactors |
IntActi | O14978, 74 interactors |
STRINGi | 9606.ENSP00000219069 |
PTM databases
iPTMneti | O14978 |
PhosphoSitePlusi | O14978 |
Genetic variation databases
BioMutai | ZNF263 |
Proteomic databases
EPDi | O14978 |
jPOSTi | O14978 |
MassIVEi | O14978 |
MaxQBi | O14978 |
PaxDbi | O14978 |
PeptideAtlasi | O14978 |
PRIDEi | O14978 |
Protocols and materials databases
Antibodypediai | 24089, 231 antibodies from 23 providers |
DNASUi | 10127 |
Genome annotation databases
Ensembli | ENST00000219069.6; ENSP00000219069.5; ENSG00000006194.10 |
GeneIDi | 10127 |
KEGGi | hsa:10127 |
MANE-Selecti | ENST00000219069.6; ENSP00000219069.5; NM_005741.5; NP_005732.2 |
UCSCi | uc002cuq.4, human |
Organism-specific databases
CTDi | 10127 |
DisGeNETi | 10127 |
GeneCardsi | ZNF263 |
HGNCi | HGNC:13056, ZNF263 |
HPAi | ENSG00000006194, Low tissue specificity |
MIMi | 604191, gene |
neXtProti | NX_O14978 |
OpenTargetsi | ENSG00000006194 |
PharmGKBi | PA37634 |
VEuPathDBi | HostDB:ENSG00000006194 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000159965 |
HOGENOMi | CLU_002678_49_8_1 |
InParanoidi | O14978 |
OMAi | NVEDKEM |
PhylomeDBi | O14978 |
TreeFami | TF350829 |
Enzyme and pathway databases
PathwayCommonsi | O14978 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
SignaLinki | O14978 |
Miscellaneous databases
BioGRID-ORCSi | 10127, 13 hits in 1100 CRISPR screens |
ChiTaRSi | ZNF263, human |
GenomeRNAii | 10127 |
Pharosi | O14978, Tbio |
PROi | PR:O14978 |
RNActi | O14978, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000006194, Expressed in calcaneal tendon and 232 other tissues |
ExpressionAtlasi | O14978, baseline and differential |
Genevisiblei | O14978, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR003309, SCAN_dom IPR038269, SCAN_sf IPR030752, ZNF263 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR23226:SF224, PTHR23226:SF224, 1 hit |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF02023, SCAN, 1 hit PF00096, zf-C2H2, 9 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 9 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 6 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 9 hits PS50157, ZINC_FINGER_C2H2_2, 9 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN263_HUMAN | |
Accessioni | O14978Primary (citable) accession number: O14978 Secondary accession number(s): B2R634, O43387, Q96H95 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | October 25, 2002 | |
Last modified: | May 25, 2022 | |
This is version 190 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families