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UniProtKB - O14978 (ZN263_HUMAN)

Entry version 190 (25 May 2022)
Sequence version 2 (25 Oct 2002)
Previous versions | rss
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Protein

Zinc finger protein 263

Gene

ZNF263

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor that binds to the consensus sequence 5'-TCCTCCC-3' and acts as a transcriptional repressor (PubMed:32051553).

Binds to the promoter region of SIX3 and recruits other proteins involved in chromatin modification and transcriptional corepression, resulting in methylation of the promoter and transcriptional repression (PubMed:32051553).

Acts as transcriptional repressor of HS3ST1 and HS3ST3A1 via binding to gene promoter regions (PubMed:32277030).

2 Publications

Miscellaneous

May be involved in the EGFR-mediated promotion of invasion and anchorage-independent growth in glioblastomas via silencing of SIX3 (PubMed:32051553). May act as a prognostic indicator in glioblastoma patients, with increased expression correlating with poor prognosis (PubMed:32051553).1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri378 – 400C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri434 – 456C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri462 – 484C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri490 – 512C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri518 – 540C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri575 – 597C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri603 – 625C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri631 – 653C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri659 – 681C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O14978

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-212436, Generic Transcription Pathway

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O14978

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 263Imported
Alternative name(s):
Zinc finger protein FPM315Imported
Zinc finger protein with KRAB and SCAN domains 12Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF263Imported
Synonyms:FPM3151 Publication, ZKSCAN12Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:13056, ZNF263

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604191, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O14978

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000006194

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		10127

Open Targets

More...OpenTargetsi		ENSG00000006194

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37634

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O14978, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF263

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000474911 – 683Zinc finger protein 263Add BLAST683

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki17Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki157Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei166PhosphoserineCombined sources1
Modified residuei178PhosphoserineCombined sources1
Cross-linki285Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki299Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki376Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki573Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki582Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated, leading to proteasomal degradation.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O14978

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O14978

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O14978

MaxQB - The MaxQuant DataBase

More...MaxQBi		O14978

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O14978

PeptideAtlas

More...PeptideAtlasi		O14978

PRoteomics IDEntifications database

More...PRIDEi		O14978

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O14978

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O14978

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000006194, Expressed in calcaneal tendon and 232 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O14978, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O14978, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000006194, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with a number of proteins involved in chromatin modification and transcriptional corepression including DNMT1, DNMT3A, HDAC2, PHF8, TRIM28/KAP1, SETDB1, EZH2, UHRF1, CBX3/HP1-gamma, and CBX5/HP1-alpha; recruits these proteins to the SIX3 promoter region, leading to SIX3 transcriptional repression (PubMed:32051553).

Interacts with MAPK3/ERK1 and MAPK1/ERK2 (PubMed:32051553).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115431, 147 interactors

Protein interaction database and analysis system

More...IntActi		O14978, 74 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000219069

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O14978, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		O14978

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O14978

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 123SCAN boxPROSITE-ProRule annotationAdd BLAST83
Domaini217 – 289KRABPROSITE-ProRule annotationAdd BLAST73

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni147 – 185DisorderedSequence analysisAdd BLAST39
Regioni230 – 301DisorderedSequence analysisAdd BLAST72
Regioni322 – 368DisorderedSequence analysisAdd BLAST47

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi246 – 269Polar residuesSequence analysisAdd BLAST24

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri378 – 400C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri434 – 456C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri462 – 484C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri490 – 512C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri518 – 540C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri575 – 597C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri603 – 625C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri631 – 653C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri659 – 681C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159965

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002678_49_8_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O14978

Identification of Orthologs from Complete Genome Data

More...OMAi		NVEDKEM

Database for complete collections of gene phylogenies

More...PhylomeDBi		O14978

TreeFam database of animal gene trees

More...TreeFami		TF350829

Family and domain databases

Conserved Domains Database

More...CDDi		cd07765, KRAB_A-box, 1 hit
cd07936, SCAN, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.4020.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR003309, SCAN_dom
IPR038269, SCAN_sf
IPR030752, ZNF263
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

The PANTHER Classification System

More...PANTHERi		PTHR23226:SF224, PTHR23226:SF224, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01352, KRAB, 1 hit
PF02023, SCAN, 1 hit
PF00096, zf-C2H2, 9 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00349, KRAB, 1 hit
SM00431, SCAN, 1 hit
SM00355, ZnF_C2H2, 9 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 6 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50805, KRAB, 1 hit
PS50804, SCAN_BOX, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 9 hits
PS50157, ZINC_FINGER_C2H2_2, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

O14978-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASGPGSQER EGLLIVKLEE DCAWSQELPP PDPGPSPEAS HLRFRRFRFQ 
        60         70         80         90        100
EAAGPREALS RLQELCHGWL RPEMRTKEQI LELLVLEQFL TILPQEIQSR 
       110        120        130        140        150
VQELHPESGE EAVTLVEDMQ RELGRLRQQV TNHGRGTEVL LEEPLPLETA 
       160        170        180        190        200
RESPSFKLEP METERSPGPR LQELLGPSPQ RDPQAVKERA LSAPWLSLFP 
       210        220        230        240        250
PEGNMEDKEM TGPQLPESLE DVAMYISQEE WGHQDPSKRA LSRDTVQESY 
       260        270        280        290        300
ENVDSLESHI PSQEVPGTQV GQGGKLWDPS VQSCKEGLSP RGPAPGEEKF 
       310        320        330        340        350
ENLEGVPSVC SENIHPQVLL PDQARGEVPW SPELGRPHDR SQGDWAPPPE 
       360        370        380        390        400
GGMEQALAGA SSGRELGRPK ELQPKKLHLC PLCGKNFSNN SNLIRHQRIH 
       410        420        430        440        450
AAERLCMGVD CTEIFGGNPR FLSLHRAHLG EEAHKCLECG KCFSQNTHLT 
       460        470        480        490        500
RHQRTHTGEK PYQCNICGKC FSCNSNLHRH QRTHTGEKPY KCPECGEIFA 
       510        520        530        540        550
HSSNLLRHQR IHTGERPYKC PECGKSFSRS SHLVIHERTH ERERLYPFSE 
       560        570        580        590        600
CGEAVSDSTP FLTNHGAHKA EKKLFECLTC GKSFRQGMHL TRHQRTHTGE 
       610        620        630        640        650
KPYKCTLCGE NFSHRSNLIR HQRIHTGEKP YTCHECGDSF SHSSNRIRHL 
       660        670        680 
RTHTGERPYK CSECGESFSR SSRLMSHQRT HTG
Length:683
Mass (Da):77,299
Last modified:October 25, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1E02C862FCE69265
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3NI39I3NI39_HUMAN
Zinc finger protein 263
ZNF263
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L2X3I3L2X3_HUMAN
Zinc finger protein 263
ZNF263
226Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L393I3L393_HUMAN
Zinc finger protein 263
ZNF263
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L0N0I3L0N0_HUMAN
Zinc finger protein 263
ZNF263
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L538I3L538_HUMAN
Zinc finger protein 263
ZNF263
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L4C4I3L4C4_HUMAN
Zinc finger protein 263
ZNF263
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DI05B4DI05_HUMAN
Zinc finger protein 263
ZNF263
331Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti118D → G in BAA21853 (PubMed:9256059).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052801310C → S. Corresponds to variant dbSNP:rs220379Ensembl.1
Natural variantiVAR_052802534V → I. Corresponds to variant dbSNP:rs34236132Ensembl.1
Natural variantiVAR_061943646R → Q. Corresponds to variant dbSNP:rs57710602Ensembl.1
Natural variantiVAR_084704646R → W Found in a patient with hypothalamic hamartoma; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs747714553Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D88827 mRNA Translation: BAA21853.1
AK312421 mRNA Translation: BAG35331.1
AC004232 Genomic DNA Translation: AAC24490.1
CH471112 Genomic DNA Translation: EAW85379.1
BC008805 mRNA Translation: AAH08805.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10499.1

NCBI Reference Sequences

More...RefSeqi		NP_005732.2, NM_005741.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000219069.6; ENSP00000219069.5; ENSG00000006194.10

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10127

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10127

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000219069.6; ENSP00000219069.5; NM_005741.5; NP_005732.2

UCSC genome browser

More...UCSCi		uc002cuq.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88827 mRNA Translation: BAA21853.1
AK312421 mRNA Translation: BAG35331.1
AC004232 Genomic DNA Translation: AAC24490.1
CH471112 Genomic DNA Translation: EAW85379.1
BC008805 mRNA Translation: AAH08805.1
CCDSiCCDS10499.1
RefSeqiNP_005732.2, NM_005741.4

3D structure databases

AlphaFoldDBiO14978
SMRiO14978
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi115431, 147 interactors
IntActiO14978, 74 interactors
STRINGi9606.ENSP00000219069

PTM databases

iPTMnetiO14978
PhosphoSitePlusiO14978

Genetic variation databases

BioMutaiZNF263

Proteomic databases

EPDiO14978
jPOSTiO14978
MassIVEiO14978
MaxQBiO14978
PaxDbiO14978
PeptideAtlasiO14978
PRIDEiO14978

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		24089, 231 antibodies from 23 providers

The DNASU plasmid repository

More...DNASUi		10127

Genome annotation databases

EnsembliENST00000219069.6; ENSP00000219069.5; ENSG00000006194.10
GeneIDi10127
KEGGihsa:10127
MANE-SelectiENST00000219069.6; ENSP00000219069.5; NM_005741.5; NP_005732.2
UCSCiuc002cuq.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10127
DisGeNETi10127

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF263
HGNCiHGNC:13056, ZNF263
HPAiENSG00000006194, Low tissue specificity
MIMi604191, gene
neXtProtiNX_O14978
OpenTargetsiENSG00000006194
PharmGKBiPA37634
VEuPathDBiHostDB:ENSG00000006194

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000159965
HOGENOMiCLU_002678_49_8_1
InParanoidiO14978
OMAiNVEDKEM
PhylomeDBiO14978
TreeFamiTF350829

Enzyme and pathway databases

PathwayCommonsiO14978
ReactomeiR-HSA-212436, Generic Transcription Pathway
SignaLinkiO14978

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10127, 13 hits in 1100 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZNF263, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10127
PharosiO14978, Tbio

Protein Ontology

More...PROi		PR:O14978
RNActiO14978, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000006194, Expressed in calcaneal tendon and 232 other tissues
ExpressionAtlasiO14978, baseline and differential
GenevisibleiO14978, HS

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
cd07936, SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR003309, SCAN_dom
IPR038269, SCAN_sf
IPR030752, ZNF263
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PANTHERiPTHR23226:SF224, PTHR23226:SF224, 1 hit
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF02023, SCAN, 1 hit
PF00096, zf-C2H2, 9 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00431, SCAN, 1 hit
SM00355, ZnF_C2H2, 9 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS50804, SCAN_BOX, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 9 hits
PS50157, ZINC_FINGER_C2H2_2, 9 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN263_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O14978
Secondary accession number(s): B2R634, O43387, Q96H95
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 25, 2002
Last modified: May 25, 2022
This is version 190 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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