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Protein

Zinc finger protein 263

Gene

ZNF263

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Might play an important role in basic cellular processes as a transcriptional repressor.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri378 – 400C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri434 – 456C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri462 – 484C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri490 – 512C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri518 – 540C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri575 – 597C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri603 – 625C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri631 – 653C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri659 – 681C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway
SignaLinkiO14978

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 263
Alternative name(s):
Zinc finger protein FPM315
Zinc finger protein with KRAB and SCAN domains 12
Gene namesi
Name:ZNF263
Synonyms:FPM315, ZKSCAN12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000006194.9
HGNCiHGNC:13056 ZNF263
MIMi604191 gene
neXtProtiNX_O14978

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000006194
PharmGKBiPA37634

Polymorphism and mutation databases

BioMutaiZNF263

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474911 – 683Zinc finger protein 263Add BLAST683

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki17Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki157Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei166PhosphoserineCombined sources1
Modified residuei178PhosphoserineCombined sources1
Cross-linki285Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki299Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki376Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki573Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki582Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO14978
MaxQBiO14978
PaxDbiO14978
PeptideAtlasiO14978
PRIDEiO14978
ProteomicsDBi48352

PTM databases

iPTMnetiO14978
PhosphoSitePlusiO14978

Expressioni

Tissue specificityi

Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte.

Gene expression databases

BgeeiENSG00000006194 Expressed in 219 organ(s), highest expression level in pituitary gland
CleanExiHS_ZNF263
ExpressionAtlasiO14978 baseline and differential
GenevisibleiO14978 HS

Organism-specific databases

HPAiHPA035085
HPA035086

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi115431, 72 interactors
IntActiO14978, 18 interactors
STRINGi9606.ENSP00000219069

Structurei

3D structure databases

ProteinModelPortaliO14978
SMRiO14978
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 123SCAN boxPROSITE-ProRule annotationAdd BLAST83
Domaini217 – 289KRABPROSITE-ProRule annotationAdd BLAST73

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri378 – 400C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri434 – 456C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri462 – 484C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri490 – 512C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri518 – 540C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri575 – 597C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri603 – 625C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri631 – 653C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri659 – 681C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144000
HOGENOMiHOG000234619
HOVERGENiHBG018163
InParanoidiO14978
KOiK09229
OMAiYPFSECG
OrthoDBiEOG091G02UG
PhylomeDBiO14978
TreeFamiTF350829

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
cd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 9 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

O14978-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASGPGSQER EGLLIVKLEE DCAWSQELPP PDPGPSPEAS HLRFRRFRFQ
60 70 80 90 100
EAAGPREALS RLQELCHGWL RPEMRTKEQI LELLVLEQFL TILPQEIQSR
110 120 130 140 150
VQELHPESGE EAVTLVEDMQ RELGRLRQQV TNHGRGTEVL LEEPLPLETA
160 170 180 190 200
RESPSFKLEP METERSPGPR LQELLGPSPQ RDPQAVKERA LSAPWLSLFP
210 220 230 240 250
PEGNMEDKEM TGPQLPESLE DVAMYISQEE WGHQDPSKRA LSRDTVQESY
260 270 280 290 300
ENVDSLESHI PSQEVPGTQV GQGGKLWDPS VQSCKEGLSP RGPAPGEEKF
310 320 330 340 350
ENLEGVPSVC SENIHPQVLL PDQARGEVPW SPELGRPHDR SQGDWAPPPE
360 370 380 390 400
GGMEQALAGA SSGRELGRPK ELQPKKLHLC PLCGKNFSNN SNLIRHQRIH
410 420 430 440 450
AAERLCMGVD CTEIFGGNPR FLSLHRAHLG EEAHKCLECG KCFSQNTHLT
460 470 480 490 500
RHQRTHTGEK PYQCNICGKC FSCNSNLHRH QRTHTGEKPY KCPECGEIFA
510 520 530 540 550
HSSNLLRHQR IHTGERPYKC PECGKSFSRS SHLVIHERTH ERERLYPFSE
560 570 580 590 600
CGEAVSDSTP FLTNHGAHKA EKKLFECLTC GKSFRQGMHL TRHQRTHTGE
610 620 630 640 650
KPYKCTLCGE NFSHRSNLIR HQRIHTGEKP YTCHECGDSF SHSSNRIRHL
660 670 680
RTHTGERPYK CSECGESFSR SSRLMSHQRT HTG
Length:683
Mass (Da):77,299
Last modified:October 25, 2002 - v2
Checksum:i1E02C862FCE69265
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3NI39I3NI39_HUMAN
Zinc finger protein 263
ZNF263
141Annotation score:
I3L393I3L393_HUMAN
Zinc finger protein 263
ZNF263
149Annotation score:
I3L2X3I3L2X3_HUMAN
Zinc finger protein 263
ZNF263
226Annotation score:
I3L0N0I3L0N0_HUMAN
Zinc finger protein 263
ZNF263
115Annotation score:
B4DI05B4DI05_HUMAN
cDNA FLJ57935, highly similar to Zi...
ZNF263
331Annotation score:
I3L538I3L538_HUMAN
Zinc finger protein 263
ZNF263
51Annotation score:
I3L4C4I3L4C4_HUMAN
Zinc finger protein 263
ZNF263
115Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti118D → G in BAA21853 (PubMed:9256059).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052801310C → S. Corresponds to variant dbSNP:rs220379Ensembl.1
Natural variantiVAR_052802534V → I. Corresponds to variant dbSNP:rs34236132Ensembl.1
Natural variantiVAR_061943646R → Q. Corresponds to variant dbSNP:rs57710602Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88827 mRNA Translation: BAA21853.1
AK312421 mRNA Translation: BAG35331.1
AC004232 Genomic DNA Translation: AAC24490.1
CH471112 Genomic DNA Translation: EAW85379.1
BC008805 mRNA Translation: AAH08805.1
CCDSiCCDS10499.1
RefSeqiNP_005732.2, NM_005741.4
UniGeneiHs.611475

Genome annotation databases

EnsembliENST00000219069; ENSP00000219069; ENSG00000006194
GeneIDi10127
KEGGihsa:10127
UCSCiuc002cuq.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88827 mRNA Translation: BAA21853.1
AK312421 mRNA Translation: BAG35331.1
AC004232 Genomic DNA Translation: AAC24490.1
CH471112 Genomic DNA Translation: EAW85379.1
BC008805 mRNA Translation: AAH08805.1
CCDSiCCDS10499.1
RefSeqiNP_005732.2, NM_005741.4
UniGeneiHs.611475

3D structure databases

ProteinModelPortaliO14978
SMRiO14978
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115431, 72 interactors
IntActiO14978, 18 interactors
STRINGi9606.ENSP00000219069

PTM databases

iPTMnetiO14978
PhosphoSitePlusiO14978

Polymorphism and mutation databases

BioMutaiZNF263

Proteomic databases

EPDiO14978
MaxQBiO14978
PaxDbiO14978
PeptideAtlasiO14978
PRIDEiO14978
ProteomicsDBi48352

Protocols and materials databases

DNASUi10127
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000219069; ENSP00000219069; ENSG00000006194
GeneIDi10127
KEGGihsa:10127
UCSCiuc002cuq.4 human

Organism-specific databases

CTDi10127
EuPathDBiHostDB:ENSG00000006194.9
GeneCardsiZNF263
HGNCiHGNC:13056 ZNF263
HPAiHPA035085
HPA035086
MIMi604191 gene
neXtProtiNX_O14978
OpenTargetsiENSG00000006194
PharmGKBiPA37634
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144000
HOGENOMiHOG000234619
HOVERGENiHBG018163
InParanoidiO14978
KOiK09229
OMAiYPFSECG
OrthoDBiEOG091G02UG
PhylomeDBiO14978
TreeFamiTF350829

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway
SignaLinkiO14978

Miscellaneous databases

ChiTaRSiZNF263 human
GenomeRNAii10127
PROiPR:O14978
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000006194 Expressed in 219 organ(s), highest expression level in pituitary gland
CleanExiHS_ZNF263
ExpressionAtlasiO14978 baseline and differential
GenevisibleiO14978 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
cd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 9 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN263_HUMAN
AccessioniPrimary (citable) accession number: O14978
Secondary accession number(s): B2R634, O43387, Q96H95
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 25, 2002
Last modified: November 7, 2018
This is version 169 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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