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Protein

Antizyme inhibitor 1

Gene

AZIN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding (PubMed:17900240, PubMed:26305948). Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:17900240).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ornithine decarboxylase activator activity Source: UniProtKB
  • ornithine decarboxylase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processPolyamine biosynthesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-350562 Regulation of ornithine decarboxylase (ODC)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Antizyme inhibitor 1
Short name:
AZI
Short name:
AZI1
Alternative name(s):
Ornithine decarboxylase antizyme inhibitor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AZIN1
Synonyms:OAZI, OAZIN
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000155096.13

Human Gene Nomenclature Database

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HGNCi
HGNC:16432 AZIN1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
607909 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O14977

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
51582

Open Targets

More...
OpenTargetsi
ENSG00000155096

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31887

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
AZIN1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001499921 – 448Antizyme inhibitor 1Add BLAST448

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated, leading to its proteasomal degradation; a process that is reduced in presence of antizyme OAZ1.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei69Not modifiedBy similarity1

Keywords - PTMi

Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O14977

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O14977

PeptideAtlas

More...
PeptideAtlasi
O14977

PRoteomics IDEntifications database

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PRIDEi
O14977

ProteomicsDB human proteome resource

More...
ProteomicsDBi
48351

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O14977

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O14977

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in liver.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000155096 Expressed in 238 organ(s), highest expression level in bronchial epithelial cell

CleanEx database of gene expression profiles

More...
CleanExi
HS_AZIN1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O14977 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O14977 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA027948

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer (PubMed:26305948). Interacts with OAZ1 and OAZ3; this interaction disrupts the interaction between the antizyme and ODC1 (Probable).1 Publication1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
OAZ3Q9UMX23EBI-1054824,EBI-10281601

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
119621, 17 interactors

Protein interaction database and analysis system

More...
IntActi
O14977, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000321507

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4ZGZX-ray5.81A/C2-437[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O14977

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O14977

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0622 Eukaryota
COG0019 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155396

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000274133

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG005456

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O14977

Identification of Orthologs from Complete Genome Data

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OMAi
VFCRILC

Database of Orthologous Groups

More...
OrthoDBi
725914at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O14977

TreeFam database of animal gene trees

More...
TreeFami
TF300760

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.37.10, 1 hit
3.20.20.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009006 Ala_racemase/Decarboxylase_C
IPR031178 Azin1
IPR022643 De-COase2_C
IPR022657 De-COase2_CS
IPR022644 De-COase2_N
IPR000183 Orn/DAP/Arg_de-COase
IPR002433 Orn_de-COase
IPR029066 PLP-binding_barrel

The PANTHER Classification System

More...
PANTHERi
PTHR11482 PTHR11482, 1 hit
PTHR11482:SF7 PTHR11482:SF7, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02784 Orn_Arg_deC_N, 1 hit
PF00278 Orn_DAP_Arg_deC, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01179 ODADCRBXLASE
PR01182 ORNDCRBXLASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00879 ODR_DC_2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O14977-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKGFIDDANY SVGLLDEGTN LGNVIDNYVY EHTLTGKNAF FVGDLGKIVK
60 70 80 90 100
KHSQWQNVVA QIKPFYTVKC NSAPAVLEIL AALGTGFACS SKNEMALVQE
110 120 130 140 150
LGVPPENIIY ISPCKQVSQI KYAAKVGVNI LTCDNEIELK KIARNHPNAK
160 170 180 190 200
VLLHIATEDN IGGEEGNMKF GTTLKNCRHL LECAKELDVQ IIGVKFHVSS
210 220 230 240 250
ACKESQVYVH ALSDARCVFD MAGEIGFTMN MLDIGGGFTG TEFQLEEVNH
260 270 280 290 300
VISPLLDIYF PEGSGVKIIS EPGSYYVSSA FTLAVNIIAK KVVENDKFPS
310 320 330 340 350
GVEKTGSDEP AFMYYMNDGV YGSFASKLSE DLNTIPEVHK KYKEDEPLFT
360 370 380 390 400
SSLWGPSCDE LDQIVESCLL PELNVGDWLI FDNMGADSFH EPSAFNDFQR
410 420 430 440
PAIYYMMSFS DWYEMQDAGI TSDSMMKNFF FVPSCIQLSQ EDSFSAEA
Length:448
Mass (Da):49,535
Last modified:August 15, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDD26B22A993318E4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RIB7E5RIB7_HUMAN
Antizyme inhibitor 1
AZIN1
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KQI8U3KQI8_HUMAN
Antizyme inhibitor 1
AZIN1
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJ16E5RJ16_HUMAN
Antizyme inhibitor 1
AZIN1
33Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti20N → D in BAA23593 (PubMed:9349715).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
D88674 mRNA Translation: BAA23593.1
BT006858 mRNA Translation: AAP35504.1
CR456745 mRNA Translation: CAG33026.1
AP003354 Genomic DNA No translation available.
CH471060 Genomic DNA Translation: EAW91851.1
BC013420 mRNA Translation: AAH13420.1
BC019279 mRNA Translation: AAH19279.1
AF070634 mRNA Translation: AAC25391.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS6295.1

NCBI Reference Sequences

More...
RefSeqi
NP_056962.2, NM_015878.5
NP_680479.1, NM_148174.3
XP_011515428.1, XM_011517126.1
XP_011515429.1, XM_011517127.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.459106

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000337198; ENSP00000337180; ENSG00000155096
ENST00000347770; ENSP00000321507; ENSG00000155096

Database of genes from NCBI RefSeq genomes

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GeneIDi
51582

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:51582

UCSC genome browser

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UCSCi
uc003ykx.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88674 mRNA Translation: BAA23593.1
BT006858 mRNA Translation: AAP35504.1
CR456745 mRNA Translation: CAG33026.1
AP003354 Genomic DNA No translation available.
CH471060 Genomic DNA Translation: EAW91851.1
BC013420 mRNA Translation: AAH13420.1
BC019279 mRNA Translation: AAH19279.1
AF070634 mRNA Translation: AAC25391.1
CCDSiCCDS6295.1
RefSeqiNP_056962.2, NM_015878.5
NP_680479.1, NM_148174.3
XP_011515428.1, XM_011517126.1
XP_011515429.1, XM_011517127.1
UniGeneiHs.459106

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4ZGZX-ray5.81A/C2-437[»]
ProteinModelPortaliO14977
SMRiO14977
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119621, 17 interactors
IntActiO14977, 6 interactors
STRINGi9606.ENSP00000321507

PTM databases

iPTMnetiO14977
PhosphoSitePlusiO14977

Polymorphism and mutation databases

BioMutaiAZIN1

Proteomic databases

MaxQBiO14977
PaxDbiO14977
PeptideAtlasiO14977
PRIDEiO14977
ProteomicsDBi48351

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
51582
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337198; ENSP00000337180; ENSG00000155096
ENST00000347770; ENSP00000321507; ENSG00000155096
GeneIDi51582
KEGGihsa:51582
UCSCiuc003ykx.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51582
DisGeNETi51582
EuPathDBiHostDB:ENSG00000155096.13

GeneCards: human genes, protein and diseases

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GeneCardsi
AZIN1
HGNCiHGNC:16432 AZIN1
HPAiHPA027948
MIMi607909 gene
neXtProtiNX_O14977
OpenTargetsiENSG00000155096
PharmGKBiPA31887

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0622 Eukaryota
COG0019 LUCA
GeneTreeiENSGT00940000155396
HOGENOMiHOG000274133
HOVERGENiHBG005456
InParanoidiO14977
OMAiVFCRILC
OrthoDBi725914at2759
PhylomeDBiO14977
TreeFamiTF300760

Enzyme and pathway databases

ReactomeiR-HSA-350562 Regulation of ornithine decarboxylase (ODC)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
AZIN1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
AZIN1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
51582

Protein Ontology

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PROi
PR:O14977

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000155096 Expressed in 238 organ(s), highest expression level in bronchial epithelial cell
CleanExiHS_AZIN1
ExpressionAtlasiO14977 baseline and differential
GenevisibleiO14977 HS

Family and domain databases

Gene3Di2.40.37.10, 1 hit
3.20.20.10, 1 hit
InterProiView protein in InterPro
IPR009006 Ala_racemase/Decarboxylase_C
IPR031178 Azin1
IPR022643 De-COase2_C
IPR022657 De-COase2_CS
IPR022644 De-COase2_N
IPR000183 Orn/DAP/Arg_de-COase
IPR002433 Orn_de-COase
IPR029066 PLP-binding_barrel
PANTHERiPTHR11482 PTHR11482, 1 hit
PTHR11482:SF7 PTHR11482:SF7, 1 hit
PfamiView protein in Pfam
PF02784 Orn_Arg_deC_N, 1 hit
PF00278 Orn_DAP_Arg_deC, 1 hit
PRINTSiPR01179 ODADCRBXLASE
PR01182 ORNDCRBXLASE
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
PROSITEiView protein in PROSITE
PS00879 ODR_DC_2_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAZIN1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O14977
Secondary accession number(s): A6NCD5, Q6IBQ7, Q96D20
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: August 15, 2003
Last modified: January 16, 2019
This is version 153 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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