UniProtKB - O14976 (GAK_HUMAN)
Cyclin-G-associated kinase
GAK
Functioni
Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.
1 PublicationCatalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 173 | Proton acceptorPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- chaperone binding Source: BHF-UCL
- clathrin binding Source: GO_Central
- cyclin binding Source: ParkinsonsUK-UCL
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: ProtInc
- protein serine kinase activity Source: RHEA
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- chaperone cofactor-dependent protein refolding Source: BHF-UCL
- clathrin coat disassembly Source: ParkinsonsUK-UCL
- clathrin-coated pit assembly Source: ParkinsonsUK-UCL
- clathrin-dependent endocytosis Source: ParkinsonsUK-UCL
- endoplasmic reticulum organization Source: ParkinsonsUK-UCL
- Golgi organization Source: ParkinsonsUK-UCL
- Golgi to lysosome transport Source: ParkinsonsUK-UCL
- negative regulation of neuron projection development Source: ParkinsonsUK-UCL
- protein localization to Golgi apparatus Source: ParkinsonsUK-UCL
- protein localization to plasma membrane Source: ParkinsonsUK-UCL
- receptor-mediated endocytosis Source: ParkinsonsUK-UCL
- synaptic vesicle uncoating Source: BHF-UCL
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Cell cycle |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | O14976 |
Reactomei | R-HSA-432722, Golgi Associated Vesicle Biogenesis R-HSA-8856828, Clathrin-mediated endocytosis |
SignaLinki | O14976 |
SIGNORi | O14976 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:GAK |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4113, GAK |
MIMi | 602052, gene |
neXtProti | NX_O14976 |
VEuPathDBi | HostDB:ENSG00000178950 |
Subcellular locationi
Golgi apparatus
- trans-Golgi network 1 Publication
Other locations
- perinuclear region 1 Publication
- focal adhesion 1 Publication
Note: Localizes to the perinuclear area and to the trans-Golgi network. Also seen on the plasma membrane, probably at focal adhesions.
Cytosol
- cytosol Source: Reactome
Golgi apparatus
- Golgi apparatus Source: ParkinsonsUK-UCL
Other locations
- cytoplasm Source: GO_Central
- focal adhesion Source: UniProtKB-SubCell
- intracellular membrane-bounded organelle Source: HPA
- membrane Source: UniProtKB
- perinuclear region of cytoplasm Source: UniProtKB-SubCell
- presynapse Source: GOC
- vesicle Source: ParkinsonsUK-UCL
Keywords - Cellular componenti
Cell junction, Cytoplasm, Golgi apparatusPathology & Biotechi
Organism-specific databases
DisGeNETi | 2580 |
OpenTargetsi | ENSG00000178950 |
PharmGKBi | PA28528 |
Miscellaneous databases
Pharosi | O14976, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4355 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | O14976 |
GuidetoPHARMACOLOGYi | 2027 |
Genetic variation databases
BioMutai | GAK |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000085958 | 2 – 1311 | Cyclin-G-associated kinaseAdd BLAST | 1310 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 | |
Modified residuei | 2 | PhosphoserineBy similarity | 1 | |
Modified residuei | 16 | PhosphoserineCombined sources | 1 | |
Modified residuei | 456 | PhosphoserineCombined sources | 1 | |
Modified residuei | 770 | PhosphoserineCombined sources | 1 | |
Modified residuei | 776 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 783 | PhosphoserineCombined sources | 1 | |
Modified residuei | 794 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 811 | PhosphoserineBy similarity | 1 | |
Modified residuei | 826 | PhosphoserineCombined sources | 1 | |
Modified residuei | 829 | PhosphoserineCombined sources | 1 | |
Modified residuei | 834 | PhosphoserineCombined sources | 1 | |
Modified residuei | 939 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1096 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1123 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 1176 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1185 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, Methylation, PhosphoproteinProteomic databases
EPDi | O14976 |
jPOSTi | O14976 |
MassIVEi | O14976 |
MaxQBi | O14976 |
PaxDbi | O14976 |
PeptideAtlasi | O14976 |
PRIDEi | O14976 |
ProteomicsDBi | 48350 [O14976-1] |
PTM databases
DEPODi | GAK |
GlyGeni | O14976, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | O14976 |
PhosphoSitePlusi | O14976 |
SwissPalmi | O14976 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000178950, Expressed in endothelial cell and 243 other tissues |
ExpressionAtlasi | O14976, baseline and differential |
Genevisiblei | O14976, HS |
Organism-specific databases
HPAi | ENSG00000178950, Low tissue specificity |
Interactioni
Binary interactionsi
O14976
With | #Exp. | IntAct |
---|---|---|
ATP13A2 [Q9NQ11] | 2 | EBI-714707,EBI-6308763 |
HSPA8 [P11142] | 7 | EBI-714707,EBI-351896 |
LRRK2 [Q5S007] | 11 | EBI-714707,EBI-5323863 |
GO - Molecular functioni
- chaperone binding Source: BHF-UCL
- clathrin binding Source: GO_Central
- cyclin binding Source: ParkinsonsUK-UCL
Protein-protein interaction databases
BioGRIDi | 108853, 172 interactors |
IntActi | O14976, 103 interactors |
MINTi | O14976 |
STRINGi | 9606.ENSP00000314499 |
Chemistry databases
BindingDBi | O14976 |
Miscellaneous databases
RNActi | O14976, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | O14976 |
SMRi | O14976 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 40 – 314 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 275 | |
Domaini | 399 – 566 | Phosphatase tensin-typePROSITE-ProRule annotationAdd BLAST | 168 | |
Domaini | 572 – 710 | C2 tensin-typePROSITE-ProRule annotationAdd BLAST | 139 | |
Domaini | 1247 – 1311 | JPROSITE-ProRule annotationAdd BLAST | 65 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 709 – 729 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 749 – 788 | DisorderedSequence analysisAdd BLAST | 40 | |
Regioni | 801 – 860 | DisorderedSequence analysisAdd BLAST | 60 | |
Regioni | 913 – 1035 | DisorderedSequence analysisAdd BLAST | 123 | |
Regioni | 1047 – 1150 | DisorderedSequence analysisAdd BLAST | 104 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 801 – 822 | Basic and acidic residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 965 – 996 | Polar residuesSequence analysisAdd BLAST | 32 | |
Compositional biasi | 1066 – 1080 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1110 – 1128 | Polar residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 1130 – 1144 | Pro residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0431, Eukaryota KOG1989, Eukaryota KOG2283, Eukaryota |
GeneTreei | ENSGT00940000159527 |
HOGENOMi | CLU_007537_0_0_1 |
InParanoidi | O14976 |
OMAi | HYKNTNL |
OrthoDBi | 826336at2759 |
PhylomeDBi | O14976 |
TreeFami | TF105165 |
Family and domain databases
CDDi | cd06257, DnaJ, 1 hit |
Gene3Di | 1.10.287.110, 1 hit 3.90.190.10, 1 hit |
InterProi | View protein in InterPro IPR035892, C2_domain_sf IPR001623, DnaJ_domain IPR036869, J_dom_sf IPR011009, Kinase-like_dom_sf IPR029021, Prot-tyrosine_phosphatase-like IPR000719, Prot_kinase_dom IPR008271, Ser/Thr_kinase_AS IPR014020, Tensin_C2-dom IPR029023, Tensin_phosphatase |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit PF10409, PTEN_C2, 1 hit |
SMARTi | View protein in SMART SM00271, DnaJ, 1 hit SM01326, PTEN_C2, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF46565, SSF46565, 1 hit SSF49562, SSF49562, 1 hit SSF52799, SSF52799, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51182, C2_TENSIN, 1 hit PS50076, DNAJ_2, 1 hit PS51181, PPASE_TENSIN, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSLLQSALDF LAGPGSLGGA SGRDQSDFVG QTVELGELRL RVRRVLAEGG
60 70 80 90 100
FAFVYEAQDV GSGREYALKR LLSNEEEKNR AIIQEVCFMK KLSGHPNIVQ
110 120 130 140 150
FCSAASIGKE ESDTGQAEFL LLTELCKGQL VEFLKKMESR GPLSCDTVLK
160 170 180 190 200
IFYQTCRAVQ HMHRQKPPII HRDLKVENLL LSNQGTIKLC DFGSATTISH
210 220 230 240 250
YPDYSWSAQR RALVEEEITR NTTPMYRTPE IIDLYSNFPI GEKQDIWALG
260 270 280 290 300
CILYLLCFRQ HPFEDGAKLR IVNGKYSIPP HDTQYTVFHS LIRAMLQVNP
310 320 330 340 350
EERLSIAEVV HQLQEIAAAR NVNPKSPITE LLEQNGGYGS ATLSRGPPPP
360 370 380 390 400
VGPAGSGYSG GLALAEYDQP YGGFLDILRG GTERLFTNLK DTSSKVIQSV
410 420 430 440 450
ANYAKGDLDI SYITSRIAVM SFPAEGVESA LKNNIEDVRL FLDSKHPGHY
460 470 480 490 500
AVYNLSPRTY RPSRFHNRVS ECGWAARRAP HLHTLYNICR NMHAWLRQDH
510 520 530 540 550
KNVCVVHCMD GRAASAVAVC SFLCFCRLFS TAEAAVYMFS MKRCPPGIWP
560 570 580 590 600
SHKRYIEYMC DMVAEEPITP HSKPILVRAV VMTPVPLFSK QRSGCRPFCE
610 620 630 640 650
VYVGDERVAS TSQEYDKMRD FKIEDGKAVI PLGVTVQGDV LIVIYHARST
660 670 680 690 700
LGGRLQAKMA SMKMFQIQFH TGFVPRNATT VKFAKYDLDA CDIQEKYPDL
710 720 730 740 750
FQVNLEVEVE PRDRPSREAP PWENSSMRGL NPKILFSSRE EQQDILSKFG
760 770 780 790 800
KPELPRQPGS TAQYDAGAGS PEAEPTDSDS PPSSSADASR FLHTLDWQEE
810 820 830 840 850
KEAETGAENA SSKESESALM EDRDESEVSD EGGSPISSEG QEPRADPEPP
860 870 880 890 900
GLAAGLVQQD LVFEVETPAV LPEPVPQEDG VDLLGLHSEV GAGPAVPPQA
910 920 930 940 950
CKAPSSNTDL LSCLLGPPEA ASQGPPEDLL SEDPLLLASP APPLSVQSTP
960 970 980 990 1000
RGGPPAAADP FGPLLPSSGN NSQPCSNPDL FGEFLNSDSV TVPPSFPSAH
1010 1020 1030 1040 1050
SAPPPSCSAD FLHLGDLPGE PSKMTASSSN PDLLGGWAAW TETAASAVAP
1060 1070 1080 1090 1100
TPATEGPLFS PGGQPAPCGS QASWTKSQNP DPFADLGDLS SGLQGSPAGF
1110 1120 1130 1140 1150
PPGGFIPKTA TTPKGSSSWQ TSRPPAQGAS WPPQAKPPPK ACTQPRPNYA
1160 1170 1180 1190 1200
SNFSVIGARE ERGVRAPSFA QKPKVSENDF EDLLSNQGFS SRSDKKGPKT
1210 1220 1230 1240 1250
IAEMRKQDLA KDTDPLKLKL LDWIEGKERN IRALLSTLHT VLWDGESRWT
1260 1270 1280 1290 1300
PVGMADLVAP EQVKKHYRRA VLAVHPDKAA GQPYEQHAKM IFMELNDAWS
1310
EFENQGSRPL F
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0Y8H5 | H0Y8H5_HUMAN | Cyclin-G-associated kinase | GAK | 467 | Annotation score: | ||
H0YA39 | H0YA39_HUMAN | Cyclin-G-associated kinase | GAK | 255 | Annotation score: | ||
H0Y9M4 | H0Y9M4_HUMAN | Cyclin-G-associated kinase | GAK | 69 | Annotation score: | ||
D6RC24 | D6RC24_HUMAN | Cyclin-G-associated kinase | GAK | 70 | Annotation score: | ||
D6RAW3 | D6RAW3_HUMAN | Cyclin-G-associated kinase | GAK | 138 | Annotation score: | ||
D6RE78 | D6RE78_HUMAN | Cyclin G associated kinase, isoform... | GAK hCG_1982003 | 118 | Annotation score: | ||
D6RAQ7 | D6RAQ7_HUMAN | Cyclin-G-associated kinase | GAK | 75 | Annotation score: | ||
D6RF16 | D6RF16_HUMAN | Cyclin-G-associated kinase | GAK | 49 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 607 | R → C in AAH85005 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 1113 | P → A in BAA22623 (PubMed:9299234).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_040505 | 144 | S → L1 PublicationCorresponds to variant dbSNP:rs768962219Ensembl. | 1 | |
Natural variantiVAR_040506 | 580 | V → M1 PublicationCorresponds to variant dbSNP:rs34255232Ensembl. | 1 | |
Natural variantiVAR_040507 | 787 | D → Y1 PublicationCorresponds to variant dbSNP:rs34585705Ensembl. | 1 | |
Natural variantiVAR_040508 | 877 | Q → R1 PublicationCorresponds to variant dbSNP:rs149842313Ensembl. | 1 | |
Natural variantiVAR_040509 | 962 | G → D in a lung neuroendocrine carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs773153935Ensembl. | 1 | |
Natural variantiVAR_040510 | 1051 | T → M1 PublicationCorresponds to variant dbSNP:rs35227944Ensembl. | 1 | |
Natural variantiVAR_040511 | 1120 | Q → H1 PublicationCorresponds to variant dbSNP:rs55801437Ensembl. | 1 | |
Natural variantiVAR_040512 | 1137 | P → L1 PublicationCorresponds to variant dbSNP:rs56169884Ensembl. | 1 | |
Natural variantiVAR_040513 | 1168 | S → N1 PublicationCorresponds to variant dbSNP:rs56326341Ensembl. | 1 | |
Natural variantiVAR_040514 | 1265 | K → R1 PublicationCorresponds to variant dbSNP:rs2306242Ensembl. | 1 | |
Natural variantiVAR_040515 | 1297 | D → N1 PublicationCorresponds to variant dbSNP:rs1134921Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054479 | 49 – 127 | Missing in isoform 2. 1 PublicationAdd BLAST | 79 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D88435 mRNA Translation: BAA22623.1 BC000816 mRNA Translation: AAH00816.1 BC008668 mRNA Translation: AAH08668.1 BC085005 mRNA Translation: AAH85005.1 |
CCDSi | CCDS3340.1 [O14976-1] CCDS82902.1 [O14976-2] |
RefSeqi | NP_001305063.1, NM_001318134.1 [O14976-2] NP_005246.2, NM_005255.3 [O14976-1] |
Genome annotation databases
Ensembli | ENST00000314167.9; ENSP00000314499.4; ENSG00000178950.18 ENST00000511163.5; ENSP00000421361.1; ENSG00000178950.18 [O14976-2] |
GeneIDi | 2580 |
KEGGi | hsa:2580 |
MANE-Selecti | ENST00000314167.9; ENSP00000314499.4; NM_005255.4; NP_005246.2 |
UCSCi | uc003gbm.6, human [O14976-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D88435 mRNA Translation: BAA22623.1 BC000816 mRNA Translation: AAH00816.1 BC008668 mRNA Translation: AAH08668.1 BC085005 mRNA Translation: AAH85005.1 |
CCDSi | CCDS3340.1 [O14976-1] CCDS82902.1 [O14976-2] |
RefSeqi | NP_001305063.1, NM_001318134.1 [O14976-2] NP_005246.2, NM_005255.3 [O14976-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4C57 | X-ray | 2.55 | A/B | 14-351 | [»] | |
4C58 | X-ray | 2.16 | A | 14-351 | [»] | |
4C59 | X-ray | 2.80 | A | 14-351 | [»] | |
4O38 | X-ray | 2.10 | A/B | 12-347 | [»] | |
4Y8D | X-ray | 2.10 | A/B | 14-351 | [»] | |
5Y7Z | X-ray | 2.80 | A/B | 25-335 | [»] | |
5Y80 | X-ray | 2.50 | A | 25-335 | [»] | |
AlphaFoldDBi | O14976 | |||||
SMRi | O14976 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108853, 172 interactors |
IntActi | O14976, 103 interactors |
MINTi | O14976 |
STRINGi | 9606.ENSP00000314499 |
Chemistry databases
BindingDBi | O14976 |
ChEMBLi | CHEMBL4355 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | O14976 |
GuidetoPHARMACOLOGYi | 2027 |
PTM databases
DEPODi | GAK |
GlyGeni | O14976, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | O14976 |
PhosphoSitePlusi | O14976 |
SwissPalmi | O14976 |
Genetic variation databases
BioMutai | GAK |
Proteomic databases
EPDi | O14976 |
jPOSTi | O14976 |
MassIVEi | O14976 |
MaxQBi | O14976 |
PaxDbi | O14976 |
PeptideAtlasi | O14976 |
PRIDEi | O14976 |
ProteomicsDBi | 48350 [O14976-1] |
Protocols and materials databases
ABCDi | O14976, 2 sequenced antibodies |
Antibodypediai | 22165, 326 antibodies from 34 providers |
DNASUi | 2580 |
Genome annotation databases
Ensembli | ENST00000314167.9; ENSP00000314499.4; ENSG00000178950.18 ENST00000511163.5; ENSP00000421361.1; ENSG00000178950.18 [O14976-2] |
GeneIDi | 2580 |
KEGGi | hsa:2580 |
MANE-Selecti | ENST00000314167.9; ENSP00000314499.4; NM_005255.4; NP_005246.2 |
UCSCi | uc003gbm.6, human [O14976-1] |
Organism-specific databases
CTDi | 2580 |
DisGeNETi | 2580 |
GeneCardsi | GAK |
HGNCi | HGNC:4113, GAK |
HPAi | ENSG00000178950, Low tissue specificity |
MIMi | 602052, gene |
neXtProti | NX_O14976 |
OpenTargetsi | ENSG00000178950 |
PharmGKBi | PA28528 |
VEuPathDBi | HostDB:ENSG00000178950 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0431, Eukaryota KOG1989, Eukaryota KOG2283, Eukaryota |
GeneTreei | ENSGT00940000159527 |
HOGENOMi | CLU_007537_0_0_1 |
InParanoidi | O14976 |
OMAi | HYKNTNL |
OrthoDBi | 826336at2759 |
PhylomeDBi | O14976 |
TreeFami | TF105165 |
Enzyme and pathway databases
PathwayCommonsi | O14976 |
Reactomei | R-HSA-432722, Golgi Associated Vesicle Biogenesis R-HSA-8856828, Clathrin-mediated endocytosis |
SignaLinki | O14976 |
SIGNORi | O14976 |
Miscellaneous databases
BioGRID-ORCSi | 2580, 448 hits in 1119 CRISPR screens |
ChiTaRSi | GAK, human |
GeneWikii | GAK_(protein) |
GenomeRNAii | 2580 |
Pharosi | O14976, Tchem |
PROi | PR:O14976 |
RNActi | O14976, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000178950, Expressed in endothelial cell and 243 other tissues |
ExpressionAtlasi | O14976, baseline and differential |
Genevisiblei | O14976, HS |
Family and domain databases
CDDi | cd06257, DnaJ, 1 hit |
Gene3Di | 1.10.287.110, 1 hit 3.90.190.10, 1 hit |
InterProi | View protein in InterPro IPR035892, C2_domain_sf IPR001623, DnaJ_domain IPR036869, J_dom_sf IPR011009, Kinase-like_dom_sf IPR029021, Prot-tyrosine_phosphatase-like IPR000719, Prot_kinase_dom IPR008271, Ser/Thr_kinase_AS IPR014020, Tensin_C2-dom IPR029023, Tensin_phosphatase |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit PF10409, PTEN_C2, 1 hit |
SMARTi | View protein in SMART SM00271, DnaJ, 1 hit SM01326, PTEN_C2, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF46565, SSF46565, 1 hit SSF49562, SSF49562, 1 hit SSF52799, SSF52799, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51182, C2_TENSIN, 1 hit PS50076, DNAJ_2, 1 hit PS51181, PPASE_TENSIN, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GAK_HUMAN | |
Accessioni | O14976Primary (citable) accession number: O14976 Secondary accession number(s): Q5U4P5, Q9BVY6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 29, 2001 |
Last sequence update: | August 29, 2001 | |
Last modified: | May 25, 2022 | |
This is version 202 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families