UniProtKB - O14975 (S27A2_HUMAN)

BLAST

>sp|O14975|S27A2_HUMAN Very long-chain acyl-CoA synthetase OS=Homo sapiens OX=9606 GN=SLC27A2 PE=1 SV=2
MLSAIYTVLAGLLFLPLLVNLCCPYFFQDIGYFLKVAAVGRRVRSYGKRRPARTILRAFL
EKARQTPHKPFLLFRDETLTYAQVDRRSNQVARALHDHLGLRQGDCVALLMGNEPAYVWL
WLGLVKLGCAMACLNYNIRAKSLLHCFQCCGAKVLLVSPELQAAVEEILPSLKKDDVSIY
YVSRTSNTDGIDSFLDKVDEVSTEPIPESWRSEVTFSTPALYIYTSGTTGLPKAAMITHQ
RIWYGTGLTFVSGLKADDVIYITLPFYHSAALLIGIHGCIVAGATLALRTKFSASQFWDD
CRKYNVTVIQYIGELLRYLCNSPQKPNDRDHKVRLALGNGLRGDVWRQFVKRFGDICIYE
FYAATEGNIGFMNYARKVGAVGRVNYLQKKIITYDLIKYDVEKDEPVRDENGYCVRVPKG
EVGLLVCKITQLTPFNGYAGAKAQTEKKKLRDVFKKGDLYFNSGDLLMVDHENFIYFHDR
VGDTFRWKGENVATTEVADTVGLVDFVQEVNVYGVHVPDHEGRIGMASIKMKENHEFDGK
KLFQHIADYLPSYARPRFLRIQDTIEITGTFKHRKMTLVEEGFNPAVIKDALYFLDDTAK
MYVPMTEDIYNAISAKTLKL

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History
Entry version 158 (07 Nov 2018)
Sequence version 2 (05 Oct 2010)
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Protein

Very long-chain acyl-CoA synthetase

Gene

SLC27A2

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precursors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes (By similarity).By similarity1 Publication

Catalytic activityⁱ

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.1 Publication

ATP + a very-long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	222 – 233	AMPSequence analysisAdd BLAST		12

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
decanoate-CoA ligase activity Source: UniProtKB-EC
enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16781659
fatty acid transmembrane transporter activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
long-chain fatty acid-CoA ligase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 10198260
- 22022213
long-chain fatty acid transporter activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
phytanate-CoA ligase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 10198260
pristanate-CoA ligase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 10198260
signaling receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 20178365
very long-chain fatty acid-CoA ligase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 10198260
- 11980911

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

bile acid biosynthetic process
Source: UniProtKB
Inferred from direct assayⁱ
- 11980911
fatty acid alpha-oxidation
Source: UniProtKB
Inferred from direct assayⁱ
- 10198260
fatty acid beta-oxidation
Source: UniProtKB
Inferred from direct assayⁱ
- 10198260
long-chain fatty acid import
Source: UniProtKB
Inferred from direct assayⁱ
- 22022213
long-chain fatty acid metabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 22022213
methyl-branched fatty acid metabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 10198260
neutrophil degranulation Source: Reactome
protein targeting to peroxisome Source: Reactome
very long-chain fatty acid catabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ligase
Biological process	Fatty acid metabolism, Lipid metabolism
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS06695-MONOMER
Reactomeⁱ	R-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-389599 Alpha-oxidation of phytanate R-HSA-6798695 Neutrophil degranulation R-HSA-9033241 Peroxisomal protein import

Protein family/group databases

TCDBⁱ	4.C.1.1.5 the fatty acid transporter (fat) family

TCDBⁱ

4.C.1.1.5 the fatty acid transporter (fat) family

Chemistry databases

SwissLipidsⁱ	SLP:000000428 SLP:000000431 [O14975-2] SLP:000000432 [O14975-1]

SwissLipidsⁱ

SLP:000000428
SLP:000000431 [O14975-2]
SLP:000000432 [O14975-1]

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Very long-chain acyl-CoA synthetase (EC:6.2.1.-) Short name: VLACS Short name: VLCS Alternative name(s): Fatty acid transport protein 2 Short name: FATP-2 Fatty-acid-coenzyme A ligase, very long-chain 1 Long-chain-fatty-acid--CoA ligase (EC:6.2.1.3) Solute carrier family 27 member 2 THCA-CoA ligase Very long-chain-fatty-acid-CoA ligase
Gene namesⁱ	Name:SLC27A2 Synonyms:ACSVL1, FACVL1, FATP2, VLACS
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000140284.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10996 SLC27A2
MIMⁱ	603247 gene
neXtProtⁱ	NX_O14975

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 4	Lumenal1 Publication	4
Transmembraneⁱ	5 – 27	HelicalSequence analysisAdd BLAST	23
Topological domainⁱ	28 – 106	CytoplasmicSequence analysisAdd BLAST	79
Transmembraneⁱ	107 – 127	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	128 – 261	LumenalSequence analysisAdd BLAST	134
Transmembraneⁱ	262 – 282	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	283 – 620	CytoplasmicSequence analysisAdd BLAST	338

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane, Peroxisome

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	11001
Open Targets More...OpenTargetsⁱ	ENSG00000140284
PharmGKBⁱ	PA27971

Chemistry databases

ChEMBLⁱ

CHEMBL4326

Polymorphism and mutation databases

BioMutaⁱ	SLC27A2

BioMutaⁱ

SLC27A2

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000193204	1 – 620	Very long-chain acyl-CoA synthetaseAdd BLAST		620

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	291	N6-acetyllysineBy similarity		1
Modified residueⁱ	577	PhosphothreonineCombined sources		1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	O14975
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O14975
PaxDbⁱ	O14975
PeptideAtlas More...PeptideAtlasⁱ	O14975
PRIDEⁱ	O14975
ProteomicsDBⁱ	48348 48349 [O14975-2]

PTM databases

iPTMnetⁱ	O14975
PhosphoSitePlusⁱ	O14975

Expressionⁱ

Tissue specificityⁱ

Expressed in liver, kidney, placenta and pancreas.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000140284 Expressed in 171 organ(s), highest expression level in nephron tubule
CleanExⁱ	HS_SLC27A2
ExpressionAtlasⁱ	O14975 baseline and differential
Genevisibleⁱ	O14975 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA026089

HPAⁱ

HPA026089

Interactionⁱ

GO - Molecular functionⁱ

enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16781659
signaling receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 20178365

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	116194, 52 interactors
IntActⁱ	O14975, 10 interactors
Molecular INTeraction database More...MINTⁱ	O14975
STRINGⁱ	9606.ENSP00000267842

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O14975
SMRⁱ	O14975
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the ATP-dependent AMP-binding enzyme family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1179 Eukaryota ENOG410XQ8T LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074420
HOGENOMⁱ	HOG000044189
HOVERGENⁱ	HBG005642
InParanoidⁱ	O14975
KEGG Orthology (KO) More...KOⁱ	K08746
OMAⁱ	PMACLNY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0B76
PhylomeDBⁱ	O14975
TreeFamⁱ	TF313430

Family and domain databases

InterProⁱ	View protein in InterPro IPR025110 AMP-bd_C IPR020845 AMP-binding_CS IPR000873 AMP-dep_Synth/Lig IPR030305 FATP2
PANTHERⁱ	PTHR43107:SF13 PTHR43107:SF13, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00501 AMP-binding, 1 hit PF13193 AMP-binding_C, 1 hit
PROSITEⁱ	View protein in PROSITE PS00455 AMP_BINDING, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: O14975-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSAIYTVLA GLLFLPLLVN LCCPYFFQDI GYFLKVAAVG RRVRSYGKRR 
        60         70         80         90        100
PARTILRAFL EKARQTPHKP FLLFRDETLT YAQVDRRSNQ VARALHDHLG 
       110        120        130        140        150
LRQGDCVALL MGNEPAYVWL WLGLVKLGCA MACLNYNIRA KSLLHCFQCC 
       160        170        180        190        200
GAKVLLVSPE LQAAVEEILP SLKKDDVSIY YVSRTSNTDG IDSFLDKVDE 
       210        220        230        240        250
VSTEPIPESW RSEVTFSTPA LYIYTSGTTG LPKAAMITHQ RIWYGTGLTF 
       260        270        280        290        300
VSGLKADDVI YITLPFYHSA ALLIGIHGCI VAGATLALRT KFSASQFWDD 
       310        320        330        340        350
CRKYNVTVIQ YIGELLRYLC NSPQKPNDRD HKVRLALGNG LRGDVWRQFV 
       360        370        380        390        400
KRFGDICIYE FYAATEGNIG FMNYARKVGA VGRVNYLQKK IITYDLIKYD 
       410        420        430        440        450
VEKDEPVRDE NGYCVRVPKG EVGLLVCKIT QLTPFNGYAG AKAQTEKKKL 
       460        470        480        490        500
RDVFKKGDLY FNSGDLLMVD HENFIYFHDR VGDTFRWKGE NVATTEVADT 
       510        520        530        540        550
VGLVDFVQEV NVYGVHVPDH EGRIGMASIK MKENHEFDGK KLFQHIADYL 
       560        570        580        590        600
PSYARPRFLR IQDTIEITGT FKHRKMTLVE EGFNPAVIKD ALYFLDDTAK 
       610        620
MYVPMTEDIY NAISAKTLKL

Length:620

Mass (Da):70,312

Last modified:October 5, 2010 - v2

Checksum:ⁱ752E2FFBB2E47C26

Isoform 2 (identifier: O14975-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
230-282: Missing.

« Hide

        10         20         30         40         50
MLSAIYTVLA GLLFLPLLVN LCCPYFFQDI GYFLKVAAVG RRVRSYGKRR 
        60         70         80         90        100
PARTILRAFL EKARQTPHKP FLLFRDETLT YAQVDRRSNQ VARALHDHLG 
       110        120        130        140        150
LRQGDCVALL MGNEPAYVWL WLGLVKLGCA MACLNYNIRA KSLLHCFQCC 
       160        170        180        190        200
GAKVLLVSPE LQAAVEEILP SLKKDDVSIY YVSRTSNTDG IDSFLDKVDE 
       210        220        230        240        250
VSTEPIPESW RSEVTFSTPA LYIYTSGTTG ATLALRTKFS ASQFWDDCRK 
       260        270        280        290        300
YNVTVIQYIG ELLRYLCNSP QKPNDRDHKV RLALGNGLRG DVWRQFVKRF 
       310        320        330        340        350
GDICIYEFYA ATEGNIGFMN YARKVGAVGR VNYLQKKIIT YDLIKYDVEK 
       360        370        380        390        400
DEPVRDENGY CVRVPKGEVG LLVCKITQLT PFNGYAGAKA QTEKKKLRDV 
       410        420        430        440        450
FKKGDLYFNS GDLLMVDHEN FIYFHDRVGD TFRWKGENVA TTEVADTVGL 
       460        470        480        490        500
VDFVQEVNVY GVHVPDHEGR IGMASIKMKE NHEFDGKKLF QHIADYLPSY 
       510        520        530        540        550
ARPRFLRIQD TIEITGTFKH RKMTLVEEGF NPAVIKDALY FLDDTAKMYV 
       560 
PMTEDIYNAI SAKTLKL

Note: No experimental confirmation available.

Show »

Length:567

Mass (Da):64,616

Checksum:ⁱFF3A2B0FD68177B0

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	G3V1R7	G3V1R7_HUMAN		Solute carrier family 27 (Fatty aci... Solute carrier family 27 (Fatty acid transporter), member 2, isoform CRA_b (Very long-chain acyl-CoA synthetase)	SLC27A2 hCG_39815	385	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_046533	48	K → Q4 PublicationsCorresponds to variant dbSNP:rs1648348Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_042726	230 – 282	Missing in isoform 2. 1 PublicationAdd BLAST		53

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D88308 mRNA Translation: BAA23644.1 AF096290 mRNA Translation: AAC64973.1 AK223145 mRNA Translation: BAD96865.1 AK290262 mRNA Translation: BAF82951.1 AC009753 Genomic DNA No translation available. CH471082 Genomic DNA Translation: EAW77386.1 BC057770 mRNA Translation: AAH57770.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10133.1 [O14975-1] CCDS53943.1 [O14975-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001153101.1, NM_001159629.1 [O14975-2] NP_003636.2, NM_003645.3 [O14975-1]
UniGeneⁱ	Hs.11729

Genome annotation databases

Ensemblⁱ	ENST00000267842; ENSP00000267842; ENSG00000140284 [O14975-1] ENST00000380902; ENSP00000370289; ENSG00000140284 [O14975-2]
GeneIDⁱ	11001
KEGGⁱ	hsa:11001
UCSC genome browser More...UCSCⁱ	uc001zxw.4 human [O14975-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O14975	Solute carrier family 27 (Fatty acid transporter), member 2, isoform CRA_b		HUMAN		385	UniRef100_O14975

Protein	Similar proteins		Species	Score	Length	Source
O14975	Solute carrier family 27 (Fatty acid transporter), member 2, isoform CRA_b		HUMAN		385	UniRef90_O14975
Solute carrier family 27 member 2		SAIBB		754
Solute carrier family 27 member 2		PONAB		620
Solute carrier family 27 member 2		GORGO		620
Uncharacterized protein		PANPA		620
+25
O14975-2	SLC27A2 isoform 3		PANTR		567	UniRef90_O14975-2
Uncharacterized protein		CERAT		567
Uncharacterized protein		MANLE		567
Uncharacterized protein		PANPA		567
Uncharacterized protein		NOMLE		567
+15

Protein	Similar proteins		Species	Score	Length	Source
O14975	Long-chain fatty acid transport protein 6		HUMAN		619	UniRef50_O14975
Very long-chain acyl-CoA synthetase		RAT		620
Very long-chain acyl-CoA synthetase		MOUSE		620
Solute carrier family 27 member 2		SAIBB		754
Solute carrier family 27 member 2		PONAB		620
+714

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D88308 mRNA Translation: BAA23644.1 AF096290 mRNA Translation: AAC64973.1 AK223145 mRNA Translation: BAD96865.1 AK290262 mRNA Translation: BAF82951.1 AC009753 Genomic DNA No translation available. CH471082 Genomic DNA Translation: EAW77386.1 BC057770 mRNA Translation: AAH57770.1
CCDSⁱ	CCDS10133.1 [O14975-1] CCDS53943.1 [O14975-2]
RefSeqⁱ	NP_001153101.1, NM_001159629.1 [O14975-2] NP_003636.2, NM_003645.3 [O14975-1]
UniGeneⁱ	Hs.11729

3D structure databases

ProteinModelPortalⁱ	O14975
SMRⁱ	O14975
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116194, 52 interactors
IntActⁱ	O14975, 10 interactors
MINTⁱ	O14975
STRINGⁱ	9606.ENSP00000267842

Chemistry databases

ChEMBLⁱ	CHEMBL4326
SwissLipidsⁱ	SLP:000000428 SLP:000000431 [O14975-2] SLP:000000432 [O14975-1]

Protein family/group databases

TCDBⁱ	4.C.1.1.5 the fatty acid transporter (fat) family

TCDBⁱ

4.C.1.1.5 the fatty acid transporter (fat) family

PTM databases

iPTMnetⁱ	O14975
PhosphoSitePlusⁱ	O14975

Polymorphism and mutation databases

BioMutaⁱ	SLC27A2

BioMutaⁱ

SLC27A2

Proteomic databases

EPDⁱ	O14975
MaxQBⁱ	O14975
PaxDbⁱ	O14975
PeptideAtlasⁱ	O14975
PRIDEⁱ	O14975
ProteomicsDBⁱ	48348 48349 [O14975-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000267842; ENSP00000267842; ENSG00000140284 [O14975-1] ENST00000380902; ENSP00000370289; ENSG00000140284 [O14975-2]
GeneIDⁱ	11001
KEGGⁱ	hsa:11001
UCSCⁱ	uc001zxw.4 human [O14975-1]

Organism-specific databases

CTDⁱ	11001
DisGeNETⁱ	11001
EuPathDBⁱ	HostDB:ENSG00000140284.10
GeneCardsⁱ	SLC27A2
HGNCⁱ	HGNC:10996 SLC27A2
HPAⁱ	HPA026089
MIMⁱ	603247 gene
neXtProtⁱ	NX_O14975
OpenTargetsⁱ	ENSG00000140284
PharmGKBⁱ	PA27971
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1179 Eukaryota ENOG410XQ8T LUCA
GeneTreeⁱ	ENSGT00550000074420
HOGENOMⁱ	HOG000044189
HOVERGENⁱ	HBG005642
InParanoidⁱ	O14975
KOⁱ	K08746
OMAⁱ	PMACLNY
OrthoDBⁱ	EOG091G0B76
PhylomeDBⁱ	O14975
TreeFamⁱ	TF313430

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS06695-MONOMER
Reactomeⁱ	R-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-389599 Alpha-oxidation of phytanate R-HSA-6798695 Neutrophil degranulation R-HSA-9033241 Peroxisomal protein import

Miscellaneous databases

ChiTaRSⁱ	SLC27A2 human
GeneWikiⁱ	SLC27A2
GenomeRNAiⁱ	11001
Protein Ontology More...PROⁱ	PR:O14975
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000140284 Expressed in 171 organ(s), highest expression level in nephron tubule
CleanExⁱ	HS_SLC27A2
ExpressionAtlasⁱ	O14975 baseline and differential
Genevisibleⁱ	O14975 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR025110 AMP-bd_C IPR020845 AMP-binding_CS IPR000873 AMP-dep_Synth/Lig IPR030305 FATP2
PANTHERⁱ	PTHR43107:SF13 PTHR43107:SF13, 1 hit
Pfamⁱ	View protein in Pfam PF00501 AMP-binding, 1 hit PF13193 AMP-binding_C, 1 hit
PROSITEⁱ	View protein in PROSITE PS00455 AMP_BINDING, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	S27A2_HUMAN
Accessionⁱ	O14975Primary (citable) accession number: O14975 Secondary accession number(s): A8K2J7, Q53FY6, Q6PF09
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
	Last sequence update:	October 5, 2010
	Last modified:	November 7, 2018
	This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O14975 (S27A2_HUMAN)

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Very long-chain acyl-CoA synthetase

SLC27A2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Peroxisome

Cytosol

Endoplasmic reticulum

Extracellular region or secreted

Peroxisome

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ