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UniProtKB - O14975 (S27A2_HUMAN)

Entry version 174 (10 Feb 2021)
Sequence version 2 (05 Oct 2010)
Previous versions | rss
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Protein

Very long-chain acyl-CoA synthetase

Gene

SLC27A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acyl CoA synthetase that activates long-chain and very long-chain fatty acids (VLCFAs) by catalyzing the formation of fatty acyl-CoA (PubMed:10198260, PubMed:10749848, PubMed:11980911). Can also activate branched-chain fatty acids such as phytanic acid and pristanic acid (PubMed:10198260). Does not activate C24 bile acids, cholate and chenodeoxycholate (PubMed:11980911). In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol (PubMed:11980911). Exhibits long-chain fatty acids (LCFA) transport activity and plays an important role in hepatic fatty acid uptake (PubMed:20530735).4 Publications
Exhibits both long-chain fatty acids (LCFA) transport activity and acyl CoA synthetase towards very long-chain fatty acids (PubMed:21768100). Shows a preference for generating CoA derivatives of n-3 fatty acids, which are preferentially trafficked into phosphatidylinositol (PubMed:21768100).1 Publication
Exhibits long-chain fatty acids (LCFA) transport activity but lacks acyl CoA synthetase towards very long-chain fatty acids.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=12 µM for palmitic acid1 Publication
  1. Vmax=1.4 nmol/min/mg enzyme for palmitic acid1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi222 – 233AMPSequence analysisAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase
Biological processFatty acid metabolism, Lipid metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS06695-MONOMER

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O14975

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-193368, Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-HSA-193775, Synthesis of bile acids and bile salts via 24-hydroxycholesterol
R-HSA-389599, Alpha-oxidation of phytanate
R-HSA-6798695, Neutrophil degranulation
R-HSA-9033241, Peroxisomal protein import

SIGNOR Signaling Network Open Resource

More...SIGNORi		O14975

Protein family/group databases

Transport Classification Database

More...TCDBi		4.C.1.1.5, the fatty acid transporter (fat) family

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000000428
SLP:000000431 [O14975-2]
SLP:000000432 [O14975-1]

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Very long-chain acyl-CoA synthetase3 Publications (EC:6.2.1.-)
Short name:
VLACSBy similarity
Short name:
VLCS3 Publications
Alternative name(s):
Arachidonate--CoA ligase (EC:6.2.1.15By similarity)
Fatty acid transport protein 21 Publication
Short name:
FATP-21 Publication
Fatty-acid-coenzyme A ligase, very long-chain 1
Long-chain-fatty-acid--CoA ligase (EC:6.2.1.33 Publications)
Phytanate--CoA ligase (EC:6.2.1.241 Publication)
Solute carrier family 27 member 2
THCA-CoA ligase (EC:6.2.1.71 Publication)
Very long-chain-fatty-acid-CoA ligase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC27A2
Synonyms:ACSVL1, FACVL1, FATP2, VLACS
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:10996, SLC27A2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603247, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O14975

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000140284.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 4Lumenal1 Publication4
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei5 – 27HelicalSequence analysisAdd BLAST23
Topological domaini28 – 106Cytoplasmic1 PublicationAdd BLAST79
Transmembranei107 – 127HelicalSequence analysisAdd BLAST21
Topological domaini128 – 261Lumenal1 PublicationAdd BLAST134
Transmembranei262 – 282HelicalSequence analysisAdd BLAST21
Topological domaini283 – 620Cytoplasmic1 PublicationAdd BLAST338

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane, Microsome, Peroxisome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		11001

Open Targets

More...OpenTargetsi		ENSG00000140284

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27971

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O14975, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4326

Drug and drug target database

More...DrugBanki		DB11936, Bempedoic acid

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SLC27A2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001932041 – 620Very long-chain acyl-CoA synthetaseAdd BLAST620

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei291N6-acetyllysineBy similarity1
Modified residuei577PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O14975

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O14975

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O14975

MaxQB - The MaxQuant DataBase

More...MaxQBi		O14975

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O14975

PeptideAtlas

More...PeptideAtlasi		O14975

PRoteomics IDEntifications database

More...PRIDEi		O14975

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		48348 [O14975-1]
48349 [O14975-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O14975

MetOSite database of methionine sulfoxide sites

More...MetOSitei		O14975

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O14975

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O14975

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in liver, kidney, placenta and pancreas.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000140284, Expressed in nephron tubule and 188 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O14975, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O14975, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000140284, Tissue enriched (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116194, 69 interactors

Protein interaction database and analysis system

More...IntActi		O14975, 38 interactors

Molecular INTeraction database

More...MINTi		O14975

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000267842

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		O14975

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O14975, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ATP-dependent AMP-binding enzyme family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1179, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161137

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000022_46_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O14975

Identification of Orthologs from Complete Genome Data

More...OMAi		PMACLNY

Database of Orthologous Groups

More...OrthoDBi		298283at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O14975

TreeFam database of animal gene trees

More...TreeFami		TF313430

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.12780, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR025110, AMP-bd_C
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, AMP-dep_Synthh-like_sf
IPR030305, FATP2

The PANTHER Classification System

More...PANTHERi		PTHR43107:SF13, PTHR43107:SF13, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00501, AMP-binding, 1 hit
PF13193, AMP-binding_C, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00455, AMP_BINDING, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O14975-1) [UniParc]FASTAAdd to basket
Also known as: FATP2a1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLSAIYTVLA GLLFLPLLVN LCCPYFFQDI GYFLKVAAVG RRVRSYGKRR 
        60         70         80         90        100
PARTILRAFL EKARQTPHKP FLLFRDETLT YAQVDRRSNQ VARALHDHLG 
       110        120        130        140        150
LRQGDCVALL MGNEPAYVWL WLGLVKLGCA MACLNYNIRA KSLLHCFQCC 
       160        170        180        190        200
GAKVLLVSPE LQAAVEEILP SLKKDDVSIY YVSRTSNTDG IDSFLDKVDE 
       210        220        230        240        250
VSTEPIPESW RSEVTFSTPA LYIYTSGTTG LPKAAMITHQ RIWYGTGLTF 
       260        270        280        290        300
VSGLKADDVI YITLPFYHSA ALLIGIHGCI VAGATLALRT KFSASQFWDD 
       310        320        330        340        350
CRKYNVTVIQ YIGELLRYLC NSPQKPNDRD HKVRLALGNG LRGDVWRQFV 
       360        370        380        390        400
KRFGDICIYE FYAATEGNIG FMNYARKVGA VGRVNYLQKK IITYDLIKYD 
       410        420        430        440        450
VEKDEPVRDE NGYCVRVPKG EVGLLVCKIT QLTPFNGYAG AKAQTEKKKL 
       460        470        480        490        500
RDVFKKGDLY FNSGDLLMVD HENFIYFHDR VGDTFRWKGE NVATTEVADT 
       510        520        530        540        550
VGLVDFVQEV NVYGVHVPDH EGRIGMASIK MKENHEFDGK KLFQHIADYL 
       560        570        580        590        600
PSYARPRFLR IQDTIEITGT FKHRKMTLVE EGFNPAVIKD ALYFLDDTAK 
       610        620
MYVPMTEDIY NAISAKTLKL
Length:620
Mass (Da):70,312
Last modified:October 5, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i752E2FFBB2E47C26
GO
Isoform 2 (identifier: O14975-2) [UniParc]FASTAAdd to basket
Also known as: FATP2b1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     230-282: Missing.

Show »
Length:567
Mass (Da):64,616
Checksum:iFF3A2B0FD68177B0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V1R7G3V1R7_HUMAN
Solute carrier family 27 (Fatty aci...
SLC27A2 hCG_39815
385Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04653348K → Q4 PublicationsCorresponds to variant dbSNP:rs1648348Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_042726230 – 282Missing in isoform 2. 1 PublicationAdd BLAST53

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D88308 mRNA Translation: BAA23644.1
AF096290 mRNA Translation: AAC64973.1
AK223145 mRNA Translation: BAD96865.1
AK290262 mRNA Translation: BAF82951.1
AC009753 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77386.1
BC057770 mRNA Translation: AAH57770.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10133.1 [O14975-1]
CCDS53943.1 [O14975-2]

NCBI Reference Sequences

More...RefSeqi		NP_001153101.1, NM_001159629.1 [O14975-2]
NP_003636.2, NM_003645.3 [O14975-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000267842; ENSP00000267842; ENSG00000140284 [O14975-1]
ENST00000380902; ENSP00000370289; ENSG00000140284 [O14975-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		11001

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:11001

UCSC genome browser

More...UCSCi		uc001zxw.4, human [O14975-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88308 mRNA Translation: BAA23644.1
AF096290 mRNA Translation: AAC64973.1
AK223145 mRNA Translation: BAD96865.1
AK290262 mRNA Translation: BAF82951.1
AC009753 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77386.1
BC057770 mRNA Translation: AAH57770.1
CCDSiCCDS10133.1 [O14975-1]
CCDS53943.1 [O14975-2]
RefSeqiNP_001153101.1, NM_001159629.1 [O14975-2]
NP_003636.2, NM_003645.3 [O14975-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi116194, 69 interactors
IntActiO14975, 38 interactors
MINTiO14975
STRINGi9606.ENSP00000267842

Chemistry databases

BindingDBiO14975
ChEMBLiCHEMBL4326
DrugBankiDB11936, Bempedoic acid
SwissLipidsiSLP:000000428
SLP:000000431 [O14975-2]
SLP:000000432 [O14975-1]

Protein family/group databases

TCDBi4.C.1.1.5, the fatty acid transporter (fat) family

PTM databases

iPTMnetiO14975
MetOSiteiO14975
PhosphoSitePlusiO14975
SwissPalmiO14975

Genetic variation databases

BioMutaiSLC27A2

Proteomic databases

EPDiO14975
jPOSTiO14975
MassIVEiO14975
MaxQBiO14975
PaxDbiO14975
PeptideAtlasiO14975
PRIDEiO14975
ProteomicsDBi48348 [O14975-1]
48349 [O14975-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		12170, 176 antibodies

Genome annotation databases

EnsembliENST00000267842; ENSP00000267842; ENSG00000140284 [O14975-1]
ENST00000380902; ENSP00000370289; ENSG00000140284 [O14975-2]
GeneIDi11001
KEGGihsa:11001
UCSCiuc001zxw.4, human [O14975-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		11001
DisGeNETi11001

GeneCards: human genes, protein and diseases

More...GeneCardsi		SLC27A2
HGNCiHGNC:10996, SLC27A2
HPAiENSG00000140284, Tissue enriched (liver)
MIMi603247, gene
neXtProtiNX_O14975
OpenTargetsiENSG00000140284
PharmGKBiPA27971
VEuPathDBiHostDB:ENSG00000140284.10

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1179, Eukaryota
GeneTreeiENSGT00940000161137
HOGENOMiCLU_000022_46_2_1
InParanoidiO14975
OMAiPMACLNY
OrthoDBi298283at2759
PhylomeDBiO14975
TreeFamiTF313430

Enzyme and pathway databases

BioCyciMetaCyc:HS06695-MONOMER
PathwayCommonsiO14975
ReactomeiR-HSA-193368, Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-HSA-193775, Synthesis of bile acids and bile salts via 24-hydroxycholesterol
R-HSA-389599, Alpha-oxidation of phytanate
R-HSA-6798695, Neutrophil degranulation
R-HSA-9033241, Peroxisomal protein import
SIGNORiO14975

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		11001, 3 hits in 873 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SLC27A2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SLC27A2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		11001
PharosiO14975, Tbio

Protein Ontology

More...PROi		PR:O14975
RNActiO14975, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000140284, Expressed in nephron tubule and 188 other tissues
ExpressionAtlasiO14975, baseline and differential
GenevisibleiO14975, HS

Family and domain databases

Gene3Di3.40.50.12780, 1 hit
InterProiView protein in InterPro
IPR025110, AMP-bd_C
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, AMP-dep_Synthh-like_sf
IPR030305, FATP2
PANTHERiPTHR43107:SF13, PTHR43107:SF13, 1 hit
PfamiView protein in Pfam
PF00501, AMP-binding, 1 hit
PF13193, AMP-binding_C, 1 hit
PROSITEiView protein in PROSITE
PS00455, AMP_BINDING, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS27A2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O14975
Secondary accession number(s): A8K2J7, Q53FY6, Q6PF09
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 5, 2010
Last modified: February 10, 2021
This is version 174 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human variants curated from literature reports
    Index of human variants curated from literature reports
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  5. Human entries with genetic variants
    List of human entries with genetic variants
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