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Protein

Protein phosphatase 1 regulatory subunit 12A

Gene

PPP1R12A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • 14-3-3 protein binding Source: UniProtKB
  • enzyme inhibitor activity Source: UniProtKB
  • phosphatase regulator activity Source: UniProtKB
  • protein kinase binding Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
3.1.3.53 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-5625740 RHO GTPases activate PKNs
R-HSA-5625900 RHO GTPases activate CIT
R-HSA-5627117 RHO GTPases Activate ROCKs
R-HSA-5627123 RHO GTPases activate PAKs

SIGNOR Signaling Network Open Resource

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SIGNORi
O14974

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 12A
Alternative name(s):
Myosin phosphatase-targeting subunit 1
Short name:
Myosin phosphatase target subunit 1
Protein phosphatase myosin-binding subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPP1R12AImported
Synonyms:MBS, MYPT1Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000058272.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7618 PPP1R12A

Online Mendelian Inheritance in Man (OMIM)

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MIMi
602021 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O14974

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi445S → A: Abolishes phosphorylation by NUAK1 and interaction with 14-3-3; when associated with A-472 and A-910. 1
Mutagenesisi472S → A: Abolishes phosphorylation by NUAK1 and interaction with 14-3-3; when associated with A-445 and A-910. 1
Mutagenesisi473S → A: Abolishes binding to the POLO box domains of PLK1. 1 Publication1
Mutagenesisi910S → A: Abolishes phosphorylation by NUAK1 and interaction with 14-3-3; when associated with A-445 and A-472. 1
Mutagenesisi1007L → A: Loss of binding to PRKG1; when associated with A-1014. 1 Publication1
Mutagenesisi1014L → A: Loss of binding to PRKG1; when associated with A-1007. 1 Publication1
Mutagenesisi1021L → A: Loss of binding to PRKG1; when associated with A-1028. 1 Publication1
Mutagenesisi1028L → A: Loss of binding to PRKG1; when associated with A-1021. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
4659

Open Targets

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OpenTargetsi
ENSG00000058272

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA33617

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PPP1R12A

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000670251 – 1030Protein phosphatase 1 regulatory subunit 12AAdd BLAST1030

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei67(3S)-3-hydroxyasparagine; by HIF1AN; partial1 Publication1
Modified residuei100(3S)-3-hydroxyasparagine; by HIF1AN; partial1 Publication1
Modified residuei226(3S)-3-hydroxyasparagine; by HIF1AN; partial1 Publication1
Modified residuei299PhosphoserineCombined sources1
Modified residuei422PhosphoserineCombined sources1
Modified residuei432Phosphoserine1 Publication1
Modified residuei443PhosphothreonineCombined sources1
Modified residuei445Phosphoserine; by NUAK1Combined sources1 Publication1
Modified residuei446PhosphotyrosineCombined sources1
Modified residuei472Phosphoserine; by NUAK11 Publication1
Modified residuei473Phosphoserine; by CDK1Combined sources1 Publication1
Modified residuei477PhosphoserineCombined sources1
Modified residuei507PhosphoserineCombined sources1
Modified residuei509PhosphoserineCombined sources1
Modified residuei601Phosphoserine1 Publication1
Modified residuei618PhosphoserineCombined sources1
Modified residuei692Phosphoserine; by PKA and PKG; in vitro1 Publication1
Modified residuei695Phosphoserine; by PKA and PKG; in vitro1 Publication1
Modified residuei696Phosphothreonine; by ROCK1, ROCK2, CDC42BP, ZIPK/DAPK3 and RAF1Combined sources5 Publications1
Modified residuei802PhosphoserineBy similarity1
Modified residuei852Phosphoserine; by ROCK22 Publications1
Modified residuei862PhosphoserineCombined sources1
Modified residuei871PhosphoserineCombined sources1
Modified residuei903PhosphoserineCombined sources1
Modified residuei908PhosphoserineCombined sources1
Modified residuei910Phosphoserine; by NUAK1Combined sources1 Publication1
Modified residuei995PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by CIT (Rho-associated kinase) (By similarity). Phosphorylated cooperatively by ROCK1 and CDC42BP on Thr-696. Phosphorylated on upon DNA damage, probably by ATM or ATR. In vitro, phosphorylation of Ser-695 by PKA and PKG appears to prevent phosphorylation of the inhibitory site Thr-696, probably mediated by PRKG1. Phosphorylation at Ser-445, Ser-472 and Ser-910 by NUAK1 promotes interaction with 14-3-3, leading to inhibit interaction with myosin light chain MLC2, preventing dephosphorylation of MLC2. May be phosphorylated at Thr-696 by DMPK; may inhibit the myosin phosphatase activity. Phosphorylated at Ser-473 by CDK1 during mitosis, creating docking sites for the POLO box domains of PLK1. Subsequently, PLK1 binds and phosphorylates PPP1R12A.By similarity15 Publications

Keywords - PTMi

Hydroxylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O14974

MaxQB - The MaxQuant DataBase

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MaxQBi
O14974

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O14974

PeptideAtlas

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PeptideAtlasi
O14974

PRoteomics IDEntifications database

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PRIDEi
O14974

ProteomicsDB human proteome resource

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ProteomicsDBi
48344
48345 [O14974-2]
48346 [O14974-3]
48347 [O14974-4]

2D gel databases

USC-OGP 2-DE database

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OGPi
O14974

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O14974

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O14974

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in striated muscles, specifically in type 2a fibers (at protein level).1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Induced by 2-fold during pregnancy, including in abdominus rectus muscle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000058272 Expressed in 242 organ(s), highest expression level in frontal cortex

CleanEx database of gene expression profiles

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CleanExi
HS_PPP1R12A

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O14974 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O14974 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA041296
HPA071956

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, and one or several targeting or regulatory subunits. PPP1R12A mediates binding to myosin. Interacts with ARHA and CIT (By similarity). Binds PPP1R12B, ROCK1 and IL16. Interacts directly with PRKG1. Non-covalent dimer of 2 dimers; PRKG1-PRKG1 and PPP1R12A-PPP1R12A. Interacts with SMTNL1 (By similarity). Interacts with PPP1CB; the interaction is direct. Interacts (when phosphorylated at Ser-445, Ser-472 and Ser-910) with 14-3-3. Interacts with ROCK1 and ROCK2. Interacts with isoform 1 and isoform 2 of ZIPK/DAPK3. Interacts with RAF1. Interacts with HIF1AN. Interacts with NCKAP1L (PubMed:16417406).By similarity13 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
110742, 107 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
O14974

Database of interacting proteins

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DIPi
DIP-33186N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
O14974

Protein interaction database and analysis system

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IntActi
O14974, 74 interactors

Molecular INTeraction database

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MINTi
O14974

STRING: functional protein association networks

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STRINGi
9606.ENSP00000261207

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11030
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O14974

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O14974

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
O14974

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati39 – 68ANK 1Add BLAST30
Repeati72 – 101ANK 2Add BLAST30
Repeati105 – 134ANK 3Add BLAST30
Repeati138 – 164ANK 4Add BLAST27
Repeati198 – 227ANK 5Add BLAST30
Repeati231 – 260ANK 6Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni682 – 864Interaction with ROCK21 PublicationAdd BLAST183

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi35 – 38KVKF motif4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi519 – 660Ser/Thr-richAdd BLAST142
Compositional biasi721 – 753Glu/Lys-richAdd BLAST33
Compositional biasi773 – 795Ser-richAdd BLAST23

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Heterotetramerization is mediated by the interaction between a coiled-coil of PRKG1 and the leucine/isoleucine zipper of PPP1R12A/MBS, the myosin-binding subunit of the myosin phosphatase.By similarity
The KVKF motif mediates interaction with PPP1CB.1 Publication

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0505 Eukaryota
COG0666 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156120

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000290648

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG052561

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O14974

KEGG Orthology (KO)

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KOi
K06270

Identification of Orthologs from Complete Genome Data

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OMAi
PMASVTN

Database of Orthologous Groups

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OrthoDBi
EOG091G12CT

Database for complete collections of gene phylogenies

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PhylomeDBi
O14974

TreeFam database of animal gene trees

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TreeFami
TF105543

Family and domain databases

Conserved Domains Database

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CDDi
cd00204 ANK, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.25.40.20, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR017401 MYPT1/MYPT2/Mbs85
IPR031775 PRKG1_interact

Pfam protein domain database

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Pfami
View protein in Pfam
PF12796 Ank_2, 2 hits
PF15898 PRKG1_interact, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF038141 PP1_12ABC_vert, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01415 ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00248 ANK, 6 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48403 SSF48403, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O14974-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKMADAKQKR NEQLKRWIGS ETDLEPPVVK RQKTKVKFDD GAVFLAACSS
60 70 80 90 100
GDTDEVLKLL HRGADINYAN VDGLTALHQA CIDDNVDMVK FLVENGANIN
110 120 130 140 150
QPDNEGWIPL HAAASCGYLD IAEFLIGQGA HVGAVNSEGD TPLDIAEEEA
160 170 180 190 200
MEELLQNEVN RQGVDIEAAR KEEERIMLRD ARQWLNSGHI NDVRHAKSGG
210 220 230 240 250
TALHVAAAKG YTEVLKLLIQ AGYDVNIKDY DGWTPLHAAA HWGKEEACRI
260 270 280 290 300
LVDNLCDMEM VNKVGQTAFD VADEDILGYL EELQKKQNLL HSEKRDKKSP
310 320 330 340 350
LIESTANMDN NQSQKTFKNK ETLIIEPEKN ASRIESLEQE KVDEEEEGKK
360 370 380 390 400
DESSCSSEED EEDDSESEAE TDKTKPLASV TNANTSSTQA APVAVTTPTV
410 420 430 440 450
SSGQATPTSP IKKFPTTATK ISPKEEERKD ESPATWRLGL RKTGSYGALA
460 470 480 490 500
EITASKEGQK EKDTAGVTRS ASSPRLSSSL DNKEKEKDSK GTRLAYVAPT
510 520 530 540 550
IPRRLASTSD IEEKENRDSS SLRTSSSYTR RKWEDDLKKN SSVNEGSTYH
560 570 580 590 600
KSCSFGRRQD DLISSSVPST TSTPTVTSAA GLQKSLLSST STTTKITTGS
610 620 630 640 650
SSAGTQSSTS NRLWAEDSTE KEKDSVPTAV TIPVAPTVVN AAASTTTLTT
660 670 680 690 700
TTAGTVSSTT EVRERRRSYL TPVRDEESES QRKARSRQAR QSRRSTQGVT
710 720 730 740 750
LTDLQEAEKT IGRSRSTRTR EQENEEKEKE EKEKQDKEKQ EEKKESETSR
760 770 780 790 800
EDEYKQKYSR TYDETYQRYR PVSTSSSTTP SSSLSTMSSS LYASSQLNRP
810 820 830 840 850
NSLVGITSAY SRGITKENER EGEKREEEKE GEDKSQPKSI RERRRPREKR
860 870 880 890 900
RSTGVSFWTQ DSDENEQEQQ SDTEEGSNKK ETQTDSISRY ETSSTSAGDR
910 920 930 940 950
YDSLLGRSGS YSYLEERKPY SSRLEKDDST DFKKLYEQIL AENEKLKAQL
960 970 980 990 1000
HDTNMELTDL KLQLEKATQR QERFADRSLL EMEKRERRAL ERRISEMEEE
1010 1020 1030
LKMLPDLKAD NQRLKDENGA LIRVISKLSK
Length:1,030
Mass (Da):115,281
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEA43E9BFF5DA08FF
GO
Isoform 2 (identifier: O14974-2) [UniParc]FASTAAdd to basket
Also known as: Myosin phosphatase target subunit 1 variant

The sequence of this isoform differs from the canonical sequence as follows:
     935-969: Missing.

Note: No experimental confirmation available.
Show »
Length:995
Mass (Da):111,185
Checksum:i67E4FF32DDCCBD78
GO
Isoform 3 (identifier: O14974-3) [UniParc]FASTAAdd to basket
Also known as: Myosin phosphatase target subunit 1 variant 2

The sequence of this isoform differs from the canonical sequence as follows:
     552-607: Missing.

Show »
Length:974
Mass (Da):109,728
Checksum:iD211212480EF48DE
GO
Isoform 4 (identifier: O14974-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     608-666: Missing.

Note: No experimental confirmation available.
Show »
Length:971
Mass (Da):109,104
Checksum:i351DE33C5EB3C276
GO
Isoform 5 (identifier: O14974-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-87: Missing.

Note: No experimental confirmation available.
Show »
Length:943
Mass (Da):105,641
Checksum:i0C4751FF983E49F9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YIM2H0YIM2_HUMAN
Protein phosphatase 1 regulatory su...
PPP1R12A
188Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VZN8F8VZN8_HUMAN
Protein phosphatase 1 regulatory su...
PPP1R12A
692Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YIS3H0YIS3_HUMAN
Protein phosphatase 1 regulatory su...
PPP1R12A
234Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RQZ1A0A0U1RQZ1_HUMAN
Protein phosphatase 1 regulatory su...
PPP1R12A
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YHL8H0YHL8_HUMAN
Protein phosphatase 1 regulatory su...
PPP1R12A
210Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VW28F8VW28_HUMAN
Protein phosphatase 1 regulatory su...
PPP1R12A
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YHI8H0YHI8_HUMAN
Protein phosphatase 1 regulatory su...
PPP1R12A
367Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YIS4H0YIS4_HUMAN
Protein phosphatase 1 regulatory su...
PPP1R12A
299Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YIL7H0YIL7_HUMAN
Protein phosphatase 1 regulatory su...
PPP1R12A
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH47898 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH92481 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2K → Q in AAI11753 (PubMed:15489334).Curated1
Sequence conflicti322T → A in AAH92481 (PubMed:15489334).Curated1
Sequence conflicti350K → R in BAG63921 (PubMed:14702039).Curated1
Sequence conflicti653A → V in AAH92481 (PubMed:15489334).Curated1
Sequence conflicti690R → G in AAQ88438 (Ref. 2) Curated1
Sequence conflicti783S → P in AAQ88438 (Ref. 2) Curated1
Sequence conflicti930T → P in AAQ88438 (Ref. 2) Curated1
Sequence conflicti959D → G in AAQ88438 (Ref. 2) Curated1
Sequence conflicti1027K → Q in AAQ88438 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_038949116C → W. Corresponds to variant dbSNP:rs12582646Ensembl.1
Natural variantiVAR_038950305T → P. Corresponds to variant dbSNP:rs2596781Ensembl.1
Natural variantiVAR_038951734K → N. Corresponds to variant dbSNP:rs12820960Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0450791 – 87Missing in isoform 5. 1 PublicationAdd BLAST87
Alternative sequenceiVSP_009251552 – 607Missing in isoform 3. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_009252608 – 666Missing in isoform 4. 1 PublicationAdd BLAST59
Alternative sequenceiVSP_009253935 – 969Missing in isoform 2. 1 PublicationAdd BLAST35

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D87930 mRNA Translation: BAA22378.1
AY380574 mRNA Translation: AAQ88438.1
AF458589 mRNA Translation: AAM49717.1
AK302692 mRNA Translation: BAG63921.1
AC018476 Genomic DNA No translation available.
AC073569 Genomic DNA No translation available.
AC074270 Genomic DNA No translation available.
BC047898 mRNA Translation: AAH47898.1 Sequence problems.
BC092481 mRNA Translation: AAH92481.1 Sequence problems.
BC111752 mRNA Translation: AAI11753.1
AB042196 Genomic DNA Translation: BAB39107.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44947.1 [O14974-1]
CCDS44948.1 [O14974-5]
CCDS58259.1 [O14974-3]
CCDS58260.1 [O14974-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001137357.1, NM_001143885.1 [O14974-1]
NP_001137358.1, NM_001143886.1 [O14974-5]
NP_001231919.1, NM_001244990.1 [O14974-2]
NP_001231921.1, NM_001244992.1 [O14974-3]
NP_002471.1, NM_002480.2 [O14974-1]
XP_011536685.1, XM_011538383.2 [O14974-4]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.49582

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000261207; ENSP00000261207; ENSG00000058272 [O14974-1]
ENST00000437004; ENSP00000416769; ENSG00000058272 [O14974-2]
ENST00000450142; ENSP00000389168; ENSG00000058272 [O14974-1]
ENST00000546369; ENSP00000449514; ENSG00000058272 [O14974-5]
ENST00000550107; ENSP00000446855; ENSG00000058272 [O14974-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4659

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4659

UCSC genome browser

More...
UCSCi
uc001syz.4 human [O14974-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87930 mRNA Translation: BAA22378.1
AY380574 mRNA Translation: AAQ88438.1
AF458589 mRNA Translation: AAM49717.1
AK302692 mRNA Translation: BAG63921.1
AC018476 Genomic DNA No translation available.
AC073569 Genomic DNA No translation available.
AC074270 Genomic DNA No translation available.
BC047898 mRNA Translation: AAH47898.1 Sequence problems.
BC092481 mRNA Translation: AAH92481.1 Sequence problems.
BC111752 mRNA Translation: AAI11753.1
AB042196 Genomic DNA Translation: BAB39107.1
CCDSiCCDS44947.1 [O14974-1]
CCDS44948.1 [O14974-5]
CCDS58259.1 [O14974-3]
CCDS58260.1 [O14974-2]
RefSeqiNP_001137357.1, NM_001143885.1 [O14974-1]
NP_001137358.1, NM_001143886.1 [O14974-5]
NP_001231919.1, NM_001244990.1 [O14974-2]
NP_001231921.1, NM_001244992.1 [O14974-3]
NP_002471.1, NM_002480.2 [O14974-1]
XP_011536685.1, XM_011538383.2 [O14974-4]
UniGeneiHs.49582

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KJYNMR-A658-714[»]
5HUZNMR-A/B931-978[»]
ProteinModelPortaliO14974
SMRiO14974
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110742, 107 interactors
CORUMiO14974
DIPiDIP-33186N
ELMiO14974
IntActiO14974, 74 interactors
MINTiO14974
STRINGi9606.ENSP00000261207

PTM databases

iPTMnetiO14974
PhosphoSitePlusiO14974

Polymorphism and mutation databases

BioMutaiPPP1R12A

2D gel databases

OGPiO14974

Proteomic databases

EPDiO14974
MaxQBiO14974
PaxDbiO14974
PeptideAtlasiO14974
PRIDEiO14974
ProteomicsDBi48344
48345 [O14974-2]
48346 [O14974-3]
48347 [O14974-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261207; ENSP00000261207; ENSG00000058272 [O14974-1]
ENST00000437004; ENSP00000416769; ENSG00000058272 [O14974-2]
ENST00000450142; ENSP00000389168; ENSG00000058272 [O14974-1]
ENST00000546369; ENSP00000449514; ENSG00000058272 [O14974-5]
ENST00000550107; ENSP00000446855; ENSG00000058272 [O14974-3]
GeneIDi4659
KEGGihsa:4659
UCSCiuc001syz.4 human [O14974-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4659
DisGeNETi4659
EuPathDBiHostDB:ENSG00000058272.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PPP1R12A

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0010848
HGNCiHGNC:7618 PPP1R12A
HPAiHPA041296
HPA071956
MIMi602021 gene
neXtProtiNX_O14974
OpenTargetsiENSG00000058272
PharmGKBiPA33617

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0505 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00940000156120
HOGENOMiHOG000290648
HOVERGENiHBG052561
InParanoidiO14974
KOiK06270
OMAiPMASVTN
OrthoDBiEOG091G12CT
PhylomeDBiO14974
TreeFamiTF105543

Enzyme and pathway databases

BRENDAi3.1.3.53 2681
ReactomeiR-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-5625740 RHO GTPases activate PKNs
R-HSA-5625900 RHO GTPases activate CIT
R-HSA-5627117 RHO GTPases Activate ROCKs
R-HSA-5627123 RHO GTPases activate PAKs
SIGNORiO14974

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PPP1R12A human
EvolutionaryTraceiO14974

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PPP1R12A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4659

Protein Ontology

More...
PROi
PR:O14974

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000058272 Expressed in 242 organ(s), highest expression level in frontal cortex
CleanExiHS_PPP1R12A
ExpressionAtlasiO14974 baseline and differential
GenevisibleiO14974 HS

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR017401 MYPT1/MYPT2/Mbs85
IPR031775 PRKG1_interact
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF15898 PRKG1_interact, 1 hit
PIRSFiPIRSF038141 PP1_12ABC_vert, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYPT1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O14974
Secondary accession number(s): B4DZ09
, F8VWB4, Q2NKL4, Q569H0, Q86WU3, Q8NFR6, Q9BYH0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 1, 1998
Last modified: December 5, 2018
This is version 180 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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