UniProtKB - O14967 (CLGN_HUMAN)

BLAST

>sp|O14967|CLGN_HUMAN Calmegin OS=Homo sapiens OX=9606 GN=CLGN PE=1 SV=1
MHFQAFWLCLGLLFISINAEFMDDDVETEDFEENSEEIDVNESELSSEIKYKTPQPIGEV
YFAETFDSGRLAGWVLSKAKKDDMDEEISIYDGRWEIEELKENQVPGDRGLVLKSRAKHH
AISAVLAKPFIFADKPLIVQYEVNFQDGIDCGGAYIKLLADTDDLILENFYDKTSYIIMF
GPDKCGEDYKLHFIFRHKHPKTGVFEEKHAKPPDVDLKKFFTDRKTHLYTLVMNPDDTFE
VLVDQTVVNKGSLLEDVVPPIKPPKEIEDPNDKKPEEWDERAKIPDPSAVKPEDWDESEP
AQIEDSSVVKPAGWLDDEPKFIPDPNAEKPDDWNEDTDGEWEAPQILNPACRIGCGEWKP
PMIDNPKYKGVWRPPLVDNPNYQGIWSPRKIPNPDYFEDDHPFLLTSFSALGLELWSMTS
DIYFDNFIICSEKEVADHWAADGWRWKIMIANANKPGVLKQLMAAAEGHPWLWLIYLVTA
GVPIALITSFCWPRKVKKKHKDTEYKKTDICIPQTKGVLEQEEKEEKAALEKPMDLEEEK
KQNDGEMLEKEEESEPEEKSEEEIEIIEGQEESNQSNKSGSEDEMKEADESTGSGDGPIK
SVRKRRVRKD

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History
Entry version 178 (07 Nov 2018)
Sequence version 1 (01 Jan 1998)
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Protein

Calmegin

Gene

CLGN

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions (By similarity).By similarity

GO - Molecular functionⁱ

calcium ion binding Source: Ensembl
protein binding involved in protein folding Source: Ensembl
unfolded protein binding
Source: ProtInc
Traceable author statementⁱ
- 9177349

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

binding of sperm to zona pellucida Source: Ensembl
protein-containing complex assembly Source: Ensembl
single fertilization
Source: ProtInc
Traceable author statementⁱ
- 9177349

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chaperone
Ligand	Calcium

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Calmegin
Gene namesⁱ	Name:CLGN
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000153132.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2060 CLGN
MIMⁱ	601858 gene
neXtProtⁱ	NX_O14967

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	20 – 471	LumenalSequence analysisAdd BLAST	452
Transmembraneⁱ	472 – 492	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	493 – 610	CytoplasmicSequence analysisAdd BLAST	118

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1047
Open Targets More...OpenTargetsⁱ	ENSG00000153132
PharmGKBⁱ	PA26587

Polymorphism and mutation databases

BioMutaⁱ	CLGN

BioMutaⁱ

CLGN

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 19	Sequence analysisAdd BLAST		19
ChainⁱPRO_0000004210	20 – 610	CalmeginAdd BLAST		591

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	128	N6-acetyllysineBy similarity	1
Disulfide bondⁱ	151 ↔ 185	By similarity
Disulfide bondⁱ	351 ↔ 355	By similarity
Modified residueⁱ	560	PhosphoserineCombined sources	1
Modified residueⁱ	576	PhosphoserineCombined sources	1
Modified residueⁱ	579	PhosphoserineBy similarity	1
Modified residueⁱ	581	PhosphoserineBy similarity	1
Modified residueⁱ	591	PhosphoserineBy similarity	1
Modified residueⁱ	594	PhosphoserineBy similarity	1
Modified residueⁱ	601	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

EPDⁱ	O14967
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O14967
PaxDbⁱ	O14967
PeptideAtlas More...PeptideAtlasⁱ	O14967
PRIDEⁱ	O14967
ProteomicsDBⁱ	48342

PTM databases

iPTMnetⁱ	O14967
PhosphoSitePlusⁱ	O14967
SwissPalmⁱ	O14967

Expressionⁱ

Tissue specificityⁱ

Detected in testis (at protein level). Detected in testis.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000153132 Expressed in 148 organ(s), highest expression level in heart right ventricle
CleanExⁱ	HS_CLGN
ExpressionAtlasⁱ	O14967 baseline and differential
Genevisibleⁱ	O14967 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB020709 HPA048761 HPA058627

HPAⁱ

CAB020709
HPA048761
HPA058627

Interactionⁱ

Subunit structureⁱ

Interacts with PPIB. Interacts with ADAM2 (By similarity). Interacts with PDILT.By similarity1 Publication

GO - Molecular functionⁱ

protein binding involved in protein folding Source: Ensembl
unfolded protein binding
Source: ProtInc
Traceable author statementⁱ
- 9177349

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107477, 38 interactors
IntActⁱ	O14967, 11 interactors
STRINGⁱ	9606.ENSP00000326699

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O14967
SMRⁱ	O14967
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	267 – 280	1-1Add BLAST	14
Repeatⁱ	284 – 297	1-2Add BLAST	14
Repeatⁱ	303 – 316	1-3Add BLAST	14
Repeatⁱ	322 – 335	1-4Add BLAST	14
Repeatⁱ	339 – 352	2-1Add BLAST	14
Repeatⁱ	356 – 369	2-2Add BLAST	14
Repeatⁱ	370 – 383	2-3Add BLAST	14
Repeatⁱ	384 – 397	2-4Add BLAST	14

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	317 – 350	Interaction with PPIBBy similarityAdd BLAST		34

Sequence similaritiesⁱ

Belongs to the calreticulin family.Curated

Keywords - Domainⁱ

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0675 Eukaryota ENOG410XP7T LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00430000030841
HOGENOMⁱ	HOG000192436
HOVERGENⁱ	HBG005407
InParanoidⁱ	O14967
KEGG Orthology (KO) More...KOⁱ	K09551
OMAⁱ	KTSYTIM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04SS
PhylomeDBⁱ	O14967
TreeFamⁱ	TF300618

Family and domain databases

Gene3Dⁱ	2.10.250.10, 1 hit
InterProⁱ	View protein in InterPro IPR001580 Calret/calnex IPR018124 Calret/calnex_CS IPR009033 Calreticulin/calnexin_P_dom_sf IPR013320 ConA-like_dom_sf
PANTHERⁱ	PTHR11073 PTHR11073, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00262 Calreticulin, 1 hit
PRINTSⁱ	PR00626 CALRETICULIN
SUPFAMⁱ	SSF49899 SSF49899, 1 hit SSF63887 SSF63887, 1 hit
PROSITEⁱ	View protein in PROSITE PS00803 CALRETICULIN_1, 1 hit PS00804 CALRETICULIN_2, 1 hit PS00805 CALRETICULIN_REPEAT, 2 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: O14967-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHFQAFWLCL GLLFISINAE FMDDDVETED FEENSEEIDV NESELSSEIK 
        60         70         80         90        100
YKTPQPIGEV YFAETFDSGR LAGWVLSKAK KDDMDEEISI YDGRWEIEEL 
       110        120        130        140        150
KENQVPGDRG LVLKSRAKHH AISAVLAKPF IFADKPLIVQ YEVNFQDGID 
       160        170        180        190        200
CGGAYIKLLA DTDDLILENF YDKTSYIIMF GPDKCGEDYK LHFIFRHKHP 
       210        220        230        240        250
KTGVFEEKHA KPPDVDLKKF FTDRKTHLYT LVMNPDDTFE VLVDQTVVNK 
       260        270        280        290        300
GSLLEDVVPP IKPPKEIEDP NDKKPEEWDE RAKIPDPSAV KPEDWDESEP 
       310        320        330        340        350
AQIEDSSVVK PAGWLDDEPK FIPDPNAEKP DDWNEDTDGE WEAPQILNPA 
       360        370        380        390        400
CRIGCGEWKP PMIDNPKYKG VWRPPLVDNP NYQGIWSPRK IPNPDYFEDD 
       410        420        430        440        450
HPFLLTSFSA LGLELWSMTS DIYFDNFIIC SEKEVADHWA ADGWRWKIMI 
       460        470        480        490        500
ANANKPGVLK QLMAAAEGHP WLWLIYLVTA GVPIALITSF CWPRKVKKKH 
       510        520        530        540        550
KDTEYKKTDI CIPQTKGVLE QEEKEEKAAL EKPMDLEEEK KQNDGEMLEK 
       560        570        580        590        600
EEESEPEEKS EEEIEIIEGQ EESNQSNKSG SEDEMKEADE STGSGDGPIK 
       610
SVRKRRVRKD

Length:610

Mass (Da):70,039

Last modified:January 1, 1998 - v1

Checksum:ⁱF024FC4010D42D7E

Isoform 2 (identifier: O14967-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
54-211: Missing.
378-424: Missing.

« Hide

        10         20         30         40         50
MHFQAFWLCL GLLFISINAE FMDDDVETED FEENSEEIDV NESELSSEIK 
        60         70         80         90        100
YKTPPDVDLK KFFTDRKTHL YTLVMNPDDT FEVLVDQTVV NKGSLLEDVV 
       110        120        130        140        150
PPIKPPKEIE DPNDKKPEEW DERAKIPDPS AVKPEDWDES EPAQIEDSSV 
       160        170        180        190        200
VKPAGWLDDE PKFIPDPNAE KPDDWNEDTD GEWEAPQILN PACRIGCGEW 
       210        220        230        240        250
KPPMIDNPKY KGVWRPPLVD NFIICSEKEV ADHWAADGWR WKIMIANANK 
       260        270        280        290        300
PGVLKQLMAA AEGHPWLWLI YLVTAGVPIA LITSFCWPRK VKKKHKDTEY 
       310        320        330        340        350
KKTDICIPQT KGVLEQEEKE EKAALEKPMD LEEEKKQNDG EMLEKEEESE 
       360        370        380        390        400
PEEKSEEEIE IIEGQEESNQ SNKSGSEDEM KEADESTGSG DGPIKSVRKR 

RVRKD

Note: No experimental confirmation available.

Show »

Length:405

Mass (Da):46,453

Checksum:ⁱ6E259D1577FA8BC6

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	D6RAZ4	D6RAZ4_HUMAN		Calmegin Calmegin	CLGN	179	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	232	V → A in BAG63520 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_024400	160	A → S. Corresponds to variant dbSNP:rs2567241Ensembl.	1
Natural variantⁱVAR_033776	290	V → I. Corresponds to variant dbSNP:rs2175563Ensembl.	1
Natural variantⁱVAR_048590	352	R → W. Corresponds to variant dbSNP:rs12513290Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_055517	54 – 211	Missing in isoform 2. 1 PublicationAdd BLAST		158
Alternative sequenceⁱVSP_055518	378 – 424	Missing in isoform 2. 1 PublicationAdd BLAST		47

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D86322 mRNA Translation: BAA22590.1 AK093096 mRNA Translation: BAG52652.1 AK302149 mRNA Translation: BAG63520.1 CH471056 Genomic DNA Translation: EAX05099.1 CH471056 Genomic DNA Translation: EAX05100.1 CH471056 Genomic DNA Translation: EAX05101.1 BC028357 mRNA Translation: AAH28357.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3751.1 [O14967-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001124147.1, NM_001130675.1 [O14967-1] NP_004353.1, NM_004362.2 [O14967-1]
UniGeneⁱ	Hs.86368

Genome annotation databases

Ensemblⁱ	ENST00000325617; ENSP00000326699; ENSG00000153132 [O14967-1] ENST00000414773; ENSP00000392782; ENSG00000153132 [O14967-1]
GeneIDⁱ	1047
KEGGⁱ	hsa:1047
UCSC genome browser More...UCSCⁱ	uc003iii.4 human [O14967-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O14967	Testis tissue sperm-binding protein Li 79P		HUMAN		610	UniRef100_O14967
cDNA FLJ55357, highly similar to Calmegin		HUMAN		527
Calmegin (Fragment)		HUMAN		179

Protein	Similar proteins		Species	Score	Length	Source
O14967	Testis tissue sperm-binding protein Li 79P		HUMAN		610	UniRef90_O14967
Uncharacterized protein		COLAP		619
Uncharacterized protein		MACFA		619
Uncharacterized protein		CERAT		612
Uncharacterized protein		PAPAN		611
+26

Protein	Similar proteins		Species	Score	Length	Source
O14967	Calnexin		HUMAN		592	UniRef50_P27824
Calnexin		PONAB		592
Calmegin		MOUSE		611
Calmegin		BOVIN		606
Calnexin	)	CANLF		593
+839
O14967-2	Uncharacterized protein		CERAT		453	UniRef50_O14967-2
Uncharacterized protein		RHIRO		460
Uncharacterized protein		MANLE		460
Uncharacterized protein		MACMU		460
Testis cDNA, clone: QtsA-14732, similar to human calmegin (CLGN)		MACFA		456
+1

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D86322 mRNA Translation: BAA22590.1 AK093096 mRNA Translation: BAG52652.1 AK302149 mRNA Translation: BAG63520.1 CH471056 Genomic DNA Translation: EAX05099.1 CH471056 Genomic DNA Translation: EAX05100.1 CH471056 Genomic DNA Translation: EAX05101.1 BC028357 mRNA Translation: AAH28357.1
CCDSⁱ	CCDS3751.1 [O14967-1]
RefSeqⁱ	NP_001124147.1, NM_001130675.1 [O14967-1] NP_004353.1, NM_004362.2 [O14967-1]
UniGeneⁱ	Hs.86368

3D structure databases

ProteinModelPortalⁱ	O14967
SMRⁱ	O14967
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107477, 38 interactors
IntActⁱ	O14967, 11 interactors
STRINGⁱ	9606.ENSP00000326699

PTM databases

iPTMnetⁱ	O14967
PhosphoSitePlusⁱ	O14967
SwissPalmⁱ	O14967

Polymorphism and mutation databases

BioMutaⁱ	CLGN

BioMutaⁱ

CLGN

Proteomic databases

EPDⁱ	O14967
MaxQBⁱ	O14967
PaxDbⁱ	O14967
PeptideAtlasⁱ	O14967
PRIDEⁱ	O14967
ProteomicsDBⁱ	48342

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1047
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000325617; ENSP00000326699; ENSG00000153132 [O14967-1] ENST00000414773; ENSP00000392782; ENSG00000153132 [O14967-1]
GeneIDⁱ	1047
KEGGⁱ	hsa:1047
UCSCⁱ	uc003iii.4 human [O14967-1]

Organism-specific databases

CTDⁱ	1047
DisGeNETⁱ	1047
EuPathDBⁱ	HostDB:ENSG00000153132.12
GeneCardsⁱ	CLGN
HGNCⁱ	HGNC:2060 CLGN
HPAⁱ	CAB020709 HPA048761 HPA058627
MIMⁱ	601858 gene
neXtProtⁱ	NX_O14967
OpenTargetsⁱ	ENSG00000153132
PharmGKBⁱ	PA26587
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0675 Eukaryota ENOG410XP7T LUCA
GeneTreeⁱ	ENSGT00430000030841
HOGENOMⁱ	HOG000192436
HOVERGENⁱ	HBG005407
InParanoidⁱ	O14967
KOⁱ	K09551
OMAⁱ	KTSYTIM
OrthoDBⁱ	EOG091G04SS
PhylomeDBⁱ	O14967
TreeFamⁱ	TF300618

Miscellaneous databases

ChiTaRSⁱ	CLGN human
GeneWikiⁱ	Calmegin
GenomeRNAiⁱ	1047
Protein Ontology More...PROⁱ	PR:O14967
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000153132 Expressed in 148 organ(s), highest expression level in heart right ventricle
CleanExⁱ	HS_CLGN
ExpressionAtlasⁱ	O14967 baseline and differential
Genevisibleⁱ	O14967 HS

Family and domain databases

Gene3Dⁱ	2.10.250.10, 1 hit
InterProⁱ	View protein in InterPro IPR001580 Calret/calnex IPR018124 Calret/calnex_CS IPR009033 Calreticulin/calnexin_P_dom_sf IPR013320 ConA-like_dom_sf
PANTHERⁱ	PTHR11073 PTHR11073, 1 hit
Pfamⁱ	View protein in Pfam PF00262 Calreticulin, 1 hit
PRINTSⁱ	PR00626 CALRETICULIN
SUPFAMⁱ	SSF49899 SSF49899, 1 hit SSF63887 SSF63887, 1 hit
PROSITEⁱ	View protein in PROSITE PS00803 CALRETICULIN_1, 1 hit PS00804 CALRETICULIN_2, 1 hit PS00805 CALRETICULIN_REPEAT, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CLGN_HUMAN
Accessionⁱ	O14967Primary (citable) accession number: O14967 Secondary accession number(s): B3KS90, B4DXV8, D3DNY8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
	Last sequence update:	January 1, 1998
	Last modified:	November 7, 2018
	This is version 178 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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UniRef

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Supporting data

UniProtKB - O14967 (CLGN_HUMAN)

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Calmegin

CLGN

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Endoplasmic reticulum

Nucleus

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ