UniProtKB - O14965 (AURKA_HUMAN)
Aurora kinase A
AURKA
Functioni
Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:26246606, PubMed:12390251, PubMed:18615013, PubMed:11039908, PubMed:17125279, PubMed:17360485).
Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed:26246606, PubMed:14523000).
Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426).
Required for initial activation of CDK1 at centrosomes (PubMed:13678582, PubMed:15128871).
Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 (PubMed:18056443, PubMed:15128871, PubMed:14702041, PubMed:11551964, PubMed:15147269, PubMed:15987997, PubMed:17604723, PubMed:18615013).
Regulates KIF2A tubulin depolymerase activity (PubMed:19351716).
Important for microtubule formation and/or stabilization (PubMed:18056443).
Required for normal axon formation (PubMed:19812038).
Plays a role in microtubule remodeling during neurite extension (PubMed:19668197).
Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 (PubMed:14702041).
Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (PubMed:11551964).
Necessary for proper cilia disassembly prior to mitosis (PubMed:17604723, PubMed:20643351).
Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (PubMed:28218735).
21 PublicationsMiscellaneous
Caution
Catalytic activityi
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 143 | ATP; via amide nitrogenCombined sources1 Publication | 1 | |
Binding sitei | 162 | ATPCombined sources1 Publication | 1 | |
Active sitei | 256 | Proton acceptorPROSITE-ProRule annotation1 Publication | 1 | |
Binding sitei | 274 | ATPCombined sources1 Publication | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 211 – 213 | ATPCombined sources1 Publication | 3 | |
Nucleotide bindingi | 260 – 261 | ATPCombined sources1 Publication | 2 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- histone serine kinase activity Source: GO_Central
- protein heterodimerization activity Source: CAFA
- protein kinase activity Source: UniProtKB
- protein kinase binding Source: UniProtKB
- protein serine/threonine/tyrosine kinase activity Source: UniProtKB
- protein serine/threonine kinase activity Source: UniProtKB
- protein serine kinase activity Source: RHEA
- ubiquitin protein ligase binding Source: Ensembl
GO - Biological processi
- anterior/posterior axis specification Source: Ensembl
- cell division Source: UniProtKB-KW
- centrosome localization Source: Ensembl
- G2/M transition of mitotic cell cycle Source: Reactome
- liver regeneration Source: MGI
- mitotic cell cycle Source: ProtInc
- mitotic centrosome separation Source: Ensembl
- mitotic spindle organization Source: GO_Central
- negative regulation of apoptotic process Source: Ensembl
- negative regulation of gene expression Source: UniProtKB
- negative regulation of protein binding Source: UniProtKB
- neuron projection extension Source: Ensembl
- peptidyl-serine phosphorylation Source: UniProtKB
- positive regulation of mitochondrial fission Source: UniProtKB
- positive regulation of mitotic nuclear division Source: UniProtKB
- positive regulation of oocyte maturation Source: Ensembl
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: Ensembl
- protein autophosphorylation Source: UniProtKB
- protein localization to centrosome Source: Ensembl
- protein phosphorylation Source: UniProtKB
- regulation of centrosome cycle Source: UniProtKB
- regulation of cytokinesis Source: GO_Central
- regulation of G2/M transition of mitotic cell cycle Source: Reactome
- regulation of protein stability Source: UniProtKB
- regulation of signal transduction by p53 class mediator Source: Reactome
- response to wounding Source: MGI
- spindle assembly involved in female meiosis I Source: Ensembl
- spindle organization Source: UniProtKB
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Cell cycle, Cell division, Cilium biogenesis/degradation, Mitosis |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 2681 |
PathwayCommonsi | O14965 |
Reactomei | R-HSA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition R-HSA-4615885, SUMOylation of DNA replication proteins R-HSA-6804114, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation R-HSA-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854518, AURKA Activation by TPX2 R-HSA-8854521, Interaction between PHLDA1 and AURKA |
SignaLinki | O14965 |
SIGNORi | O14965 |
Names & Taxonomyi
Protein namesi | Recommended name: Aurora kinase A (EC:2.7.11.16 Publications)Alternative name(s): Aurora 2 Aurora/IPL1-related kinase 1 Short name: ARK-1 Short name: Aurora-related kinase 1 Short name: hARK1 Breast tumor-amplified kinase Serine/threonine-protein kinase 15 Serine/threonine-protein kinase 6 Serine/threonine-protein kinase aurora-A |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11393, AURKA |
MIMi | 603072, gene |
neXtProti | NX_O14965 |
VEuPathDBi | HostDB:ENSG00000087586 |
Subcellular locationi
Cytoskeleton
- centrosome 11 Publications
- spindle pole 8 Publications
- cilium basal body By similarity
- centriole By similarity
Other locations
- neuron projection By similarity
Note: Detected at the neurite hillock in developing neurons (By similarity). Localizes at the centrosome in mitotic cells from early prophase until telophase, but also localizes to the spindle pole MTs from prophase to anaphase (PubMed:9606188, PubMed:17229885, PubMed:21225229). Colocalized with SIRT2 at centrosome (PubMed:22014574). Moves to the midbody during both telophase and cytokinesis (PubMed:17726514). Associates with both the pericentriolar material (PCM) and centrioles (PubMed:22014574). The localization to the spindle poles is regulated by AAAS (PubMed:26246606).By similarity6 Publications
Cytoskeleton
- centriole Source: UniProtKB-SubCell
- centrosome Source: UniProtKB
- chromosome passenger complex Source: GO_Central
- meiotic spindle Source: Ensembl
- microtubule Source: UniProtKB-KW
- microtubule cytoskeleton Source: BHF-UCL
- mitotic spindle pole Source: UniProtKB
- spindle Source: UniProtKB
- spindle midzone Source: GO_Central
- spindle pole centrosome Source: BHF-UCL
Cytosol
- cytosol Source: HPA
Nucleus
- germinal vesicle Source: Ensembl
- nucleoplasm Source: HPA
- nucleus Source: BHF-UCL
- pronucleus Source: Ensembl
Other locations
- axon hillock Source: Ensembl
- cilium Source: UniProtKB-KW
- midbody Source: UniProtKB
- perinuclear region of cytoplasm Source: BHF-UCL
Keywords - Cellular componenti
Cell projection, Cilium, Cytoplasm, Cytoskeleton, MicrotubulePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 162 | K → R: Loss of kinase activity. 1 Publication | 1 | |
Mutagenesisi | 165 | F → A: Decreases the interaction with phosphatase type 1 isoforms. 1 Publication | 1 | |
Mutagenesisi | 198 | G → N: Reduces interaction with TPX2. Reduces kinase activity tenfold. Promotes interaction with the AURKB binding partners INCENP and BIRC5 that are normally not bound by AURKA. 1 Publication | 1 | |
Mutagenesisi | 205 | R → A: Reduces ubiquitination and proteasomal degradation. 1 Publication | 1 | |
Mutagenesisi | 274 | D → N: Abolishes autophosphorylation. 1 Publication | 1 | |
Mutagenesisi | 287 | T → A: No direct effect on catalytic activity. 1 Publication | 1 | |
Mutagenesisi | 287 | T → E: Enhances interaction with TPX2. 1 Publication | 1 | |
Mutagenesisi | 288 | T → D: Mimics phosphorylation state and increases kinase activity. 1 Publication | 1 | |
Mutagenesisi | 290 | C → A: Enhances stability; when associated with A-393. 1 Publication | 1 | |
Mutagenesisi | 334 | Y → A: Reduces binding to MYCN. 1 Publication | 1 | |
Mutagenesisi | 335 | Q → A: Reduces binding to MYCN. 1 Publication | 1 | |
Mutagenesisi | 346 | F → A: Decreases the interaction with phosphatase type 1 isoforms. 1 Publication | 1 | |
Mutagenesisi | 393 | C → A: Enhances stability; when associated with A-290. 1 Publication | 1 |
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
DisGeNETi | 6790 |
MalaCardsi | AURKA |
PharmGKBi | PA36201 |
Miscellaneous databases
Pharosi | O14965, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4722 |
DrugBanki | DB07362, 1-(5-{2-[(1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)amino]ethyl}-1,3-thiazol-2-yl)-3-[3-(trifluoromethyl)phenyl]urea DB07360, 1-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}-3-[3-(trifluoromethyl)phenyl]urea DB08065, 2-(1H-pyrazol-3-yl)-1H-benzimidazole DB07186, 4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE DB07266, AKI-001 DB05220, Alisertib DB05169, AT9283 DB06347, Cenisertib DB05198, CYC116 DB06486, Enzastaurin DB12010, Fostamatinib DB13061, MLN8054 DB08066, N-[3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRAZOL-4-YL]BENZAMIDE DB07801, N-butyl-3-{[6-(9H-purin-6-ylamino)hexanoyl]amino}benzamide DB07545, N-{3-[(4-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMIDIN-2-YL)AMINO]PHENYL}CYCLOPROPANECARBOXAMIDE DB02482, Phosphonothreonine DB06134, SNS-314 |
DrugCentrali | O14965 |
GuidetoPHARMACOLOGYi | 1936 |
Genetic variation databases
BioMutai | AURKA |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000086692 | 1 – 403 | Aurora kinase AAdd BLAST | 403 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 41 | PhosphoserineCombined sources | 1 | |
Modified residuei | 51 | Phosphoserine1 Publication | 1 | |
Cross-linki | 258 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 287 | Phosphothreonine2 Publications | 1 | |
Modified residuei | 288 | Phosphothreonine7 Publications | 1 | |
Modified residuei | 342 | Phosphoserine; by PKA and PAK1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
CPTACi | CPTAC-1341 |
EPDi | O14965 |
jPOSTi | O14965 |
MassIVEi | O14965 |
MaxQBi | O14965 |
PaxDbi | O14965 |
PeptideAtlasi | O14965 |
PRIDEi | O14965 |
ProteomicsDBi | 48339 |
PTM databases
iPTMneti | O14965 |
PhosphoSitePlusi | O14965 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000087586, Expressed in oocyte and 190 other tissues |
ExpressionAtlasi | O14965, baseline and differential |
Genevisiblei | O14965, HS |
Organism-specific databases
HPAi | ENSG00000087586, Tissue enhanced (lymphoid tissue, testis) |
Interactioni
Subunit structurei
Interacts with FBXL7 (By similarity).
Interacts with CPEB1, JTB, TACC1, TPX2, PPP2CA, as well as with the protein phosphatase type 1 (PP1) isoforms PPP1CA, PPP1CB and PPP1CC.
Interacts also with its substrates ARHGEF2, BORA, KIF2A, PARD3, and p53/TP53. Interaction with BORA promotes phosphorylation of PLK1.
Interacts with PIFO.
Interacts with GADD45A, competing with its oligomerization.
Interacts (via C-terminus) with AUNIP (via C-terminus).
Identified in a complex with AUNIP and NIN.
Interacts with FRY; this interaction facilitates AURKA-mediated PLK1 phosphorylation.
Interacts with SIRT2 (PubMed:17726514, PubMed:22014574).
Interacts with MYCN; interaction is phospho-independent and triggers AURKA activation; AURKA competes with FBXW7 for binding to unphosphorylated MYCN but not for binding to phosphorylated MYCN (PubMed:27837025).
Interacts with HNRNPU (PubMed:21242313, PubMed:25986610).
Interacts with AAAS (PubMed:26246606).
Interacts with KLHL18 and CUL3 (PubMed:23213400).
Interacts with FOXP1 (PubMed:28218735).
By similarity31 PublicationsBinary interactionsi
O14965
GO - Molecular functioni
- protein heterodimerization activity Source: CAFA
- protein kinase binding Source: UniProtKB
- ubiquitin protein ligase binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 112666, 422 interactors |
CORUMi | O14965 |
DIPi | DIP-33068N |
ELMi | O14965 |
IntActi | O14965, 175 interactors |
MINTi | O14965 |
STRINGi | 9606.ENSP00000216911 |
Chemistry databases
BindingDBi | O14965 |
Miscellaneous databases
RNActi | O14965, protein |
Structurei
Secondary structure
3D structure databases
SMRi | O14965 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O14965 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 133 – 383 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 251 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 125 | DisorderedSequence analysisAdd BLAST | 125 | |
Regioni | 280 – 293 | Activation segment1 PublicationAdd BLAST | 14 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 28 – 105 | Polar residuesSequence analysisAdd BLAST | 78 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0580, Eukaryota |
InParanoidi | O14965 |
OrthoDBi | 954262at2759 |
PhylomeDBi | O14965 |
TreeFami | TF105331 |
Family and domain databases
CDDi | cd14116, STKc_Aurora-A, 1 hit |
InterProi | View protein in InterPro IPR030616, Aur IPR030611, AURKA IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
PANTHERi | PTHR24350, PTHR24350, 1 hit |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MDRSKENCIS GPVKATAPVG GPKRVLVTQQ FPCQNPLPVN SGQAQRVLCP
60 70 80 90 100
SNSSQRIPLQ AQKLVSSHKP VQNQKQKQLQ ATSVPHPVSR PLNNTQKSKQ
110 120 130 140 150
PLPSAPENNP EEELASKQKN EESKKRQWAL EDFEIGRPLG KGKFGNVYLA
160 170 180 190 200
REKQSKFILA LKVLFKAQLE KAGVEHQLRR EVEIQSHLRH PNILRLYGYF
210 220 230 240 250
HDATRVYLIL EYAPLGTVYR ELQKLSKFDE QRTATYITEL ANALSYCHSK
260 270 280 290 300
RVIHRDIKPE NLLLGSAGEL KIADFGWSVH APSSRRTTLC GTLDYLPPEM
310 320 330 340 350
IEGRMHDEKV DLWSLGVLCY EFLVGKPPFE ANTYQETYKR ISRVEFTFPD
360 370 380 390 400
FVTEGARDLI SRLLKHNPSQ RPMLREVLEH PWITANSSKP SNCQNKESAS
KQS
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA3KFJ0 | A3KFJ0_HUMAN | Aurora kinase | AURKA | 347 | Annotation score: | ||
Q5QPD4 | Q5QPD4_HUMAN | Aurora kinase | AURKA | 271 | Annotation score: | ||
A3KFJ1 | A3KFJ1_HUMAN | Aurora kinase | AURKA | 188 | Annotation score: | ||
Q5QPD2 | Q5QPD2_HUMAN | Aurora kinase | AURKA | 146 | Annotation score: | ||
Q5QPD1 | Q5QPD1_HUMAN | Aurora kinase | AURKA | 106 | Annotation score: | ||
A3KFJ2 | A3KFJ2_HUMAN | Aurora kinase A | AURKA | 79 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_030840 | 11 | G → R. Corresponds to variant dbSNP:rs6069717Ensembl. | 1 | |
Natural variantiVAR_030841 | 31 | F → I5 PublicationsCorresponds to variant dbSNP:rs2273535EnsemblClinVar. | 1 | |
Natural variantiVAR_041127 | 50 | P → L1 PublicationCorresponds to variant dbSNP:rs34572020Ensembl. | 1 | |
Natural variantiVAR_030842 | 57 | I → V Increased kinase activity. 7 PublicationsCorresponds to variant dbSNP:rs1047972Ensembl. | 1 | |
Natural variantiVAR_061745 | 104 | S → L. Corresponds to variant dbSNP:rs2230743Ensembl. | 1 | |
Natural variantiVAR_041128 | 155 | S → R in a colorectal adenocarcinoma sample; somatic mutation; reduces interaction with TPX2. 2 Publications | 1 | |
Natural variantiVAR_041129 | 174 | V → M in a metastatic melanoma sample; somatic mutation; constitutively enhanced kinase activity. 2 Publications | 1 | |
Natural variantiVAR_041130 | 373 | M → V1 PublicationCorresponds to variant dbSNP:rs33923703Ensembl. | 1 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000312783; ENSP00000321591; ENSG00000087586 ENST00000347343; ENSP00000216911; ENSG00000087586 ENST00000371356; ENSP00000360407; ENSG00000087586 ENST00000395911; ENSP00000379247; ENSG00000087586 ENST00000395913; ENSP00000379249; ENSG00000087586 ENST00000395914; ENSP00000379250; ENSG00000087586 ENST00000395915; ENSP00000379251; ENSG00000087586 |
GeneIDi | 6790 |
KEGGi | hsa:6790 |
MANE-Selecti | ENST00000395915.8; ENSP00000379251.3; NM_198437.3; NP_940839.1 |
UCSCi | uc002xxe.1, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1MQ4 | X-ray | 1.90 | A | 125-391 | [»] | |
1MUO | X-ray | 2.90 | A | 107-403 | [»] | |
1OL5 | X-ray | 2.50 | A | 122-403 | [»] | |
1OL6 | X-ray | 3.00 | A | 122-403 | [»] | |
1OL7 | X-ray | 2.75 | A | 122-403 | [»] | |
2BMC | X-ray | 2.60 | A/B/C/D/E/F | 100-403 | [»] | |
2C6D | X-ray | 2.20 | A | 124-398 | [»] | |
2C6E | X-ray | 2.10 | A/B | 123-401 | [»] | |
2DWB | X-ray | 2.50 | A | 122-403 | [»] | |
2J4Z | X-ray | 2.00 | A/B | 100-403 | [»] | |
2J50 | X-ray | 3.00 | A/B | 126-403 | [»] | |
2NP8 | X-ray | 2.25 | A | 125-391 | [»] | |
2W1C | X-ray | 3.24 | A | 122-389 | [»] | |
2W1D | X-ray | 2.97 | A | 122-389 | [»] | |
2W1E | X-ray | 2.93 | A | 122-389 | [»] | |
2W1F | X-ray | 2.85 | A | 122-389 | [»] | |
2W1G | X-ray | 2.71 | A | 122-389 | [»] | |
2WQE | X-ray | 2.50 | A | 127-388 | [»] | |
2WTV | X-ray | 2.40 | A/B/C/D | 122-403 | [»] | |
2WTW | X-ray | 3.30 | A | 122-403 | [»] | |
2X6D | X-ray | 2.80 | A | 122-403 | [»] | |
2X6E | X-ray | 3.35 | A | 122-403 | [»] | |
2X81 | X-ray | 2.91 | A | 126-391 | [»] | |
2XNE | X-ray | 2.80 | A | 122-392 | [»] | |
2XNG | X-ray | 2.60 | A | 122-403 | [»] | |
2XRU | X-ray | 2.90 | A | 126-403 | [»] | |
3COH | X-ray | 2.70 | A/B | 124-391 | [»] | |
3E5A | X-ray | 2.30 | A | 125-391 | [»] | |
3EFW | X-ray | 2.29 | A/B | 125-391 | [»] | |
3FDN | X-ray | 1.90 | A | 123-401 | [»] | |
3H0Y | X-ray | 2.50 | A | 124-391 | [»] | |
3H0Z | X-ray | 2.92 | A/B/C | 124-391 | [»] | |
3H10 | X-ray | 2.20 | A/B/D | 124-391 | [»] | |
3HA6 | X-ray | 2.36 | A | 125-391 | [»] | |
3K5U | X-ray | 2.35 | A | 123-401 | [»] | |
3LAU | X-ray | 2.10 | A | 125-399 | [»] | |
3M11 | X-ray | 2.75 | A | 123-401 | [»] | |
3MYG | X-ray | 2.40 | A | 125-391 | [»] | |
3NRM | X-ray | 3.05 | A | 126-403 | [»] | |
3O50 | X-ray | 2.00 | A/B | 125-391 | [»] | |
3O51 | X-ray | 3.20 | A | 125-391 | [»] | |
3P9J | X-ray | 2.80 | A | 125-391 | [»] | |
3QBN | X-ray | 3.50 | A | 124-403 | [»] | |
3R21 | X-ray | 2.90 | A | 126-391 | [»] | |
3R22 | X-ray | 2.90 | A | 126-391 | [»] | |
3UNZ | X-ray | 2.80 | A/B | 123-401 | [»] | |
3UO4 | X-ray | 2.45 | A | 123-401 | [»] | |
3UO5 | X-ray | 2.70 | A | 123-401 | [»] | |
3UO6 | X-ray | 2.80 | A/B | 123-401 | [»] | |
3UOD | X-ray | 2.50 | A | 123-401 | [»] | |
3UOH | X-ray | 2.80 | A/B | 123-401 | [»] | |
3UOJ | X-ray | 2.90 | A/B | 123-401 | [»] | |
3UOK | X-ray | 2.95 | A/B | 123-401 | [»] | |
3UOL | X-ray | 2.40 | A/B | 123-401 | [»] | |
3UP2 | X-ray | 2.30 | A | 123-401 | [»] | |
3UP7 | X-ray | 3.05 | A | 123-401 | [»] | |
3VAP | X-ray | 2.66 | A | 125-391 | [»] | |
3W10 | X-ray | 2.70 | A | 126-403 | [»] | |
3W16 | X-ray | 2.80 | A | 126-403 | [»] | |
3W18 | X-ray | 2.50 | A/B | 126-403 | [»] | |
3W2C | X-ray | 2.45 | A/C/E/G | 128-388 | [»] | |
4B0G | X-ray | 2.50 | A | 122-403 | [»] | |
4BN1 | X-ray | 2.50 | A | 122-403 | [»] | |
4BYI | X-ray | 2.60 | A | 122-403 | [»] | |
4BYJ | X-ray | 2.75 | A | 122-403 | [»] | |
4C3P | X-ray | 2.69 | A/D | 122-403 | [»] | |
4C3R | X-ray | 2.79 | A | 122-403 | [»] | |
4CEG | X-ray | 2.10 | A | 122-403 | [»] | |
4DEA | X-ray | 2.45 | A | 123-401 | [»] | |
4DEB | X-ray | 3.05 | A | 123-401 | [»] | |
4DED | X-ray | 3.05 | A | 123-401 | [»] | |
4DEE | X-ray | 2.30 | A | 123-401 | [»] | |
4DHF | X-ray | 2.80 | A/B | 126-391 | [»] | |
4J8M | X-ray | 1.85 | A | 123-401 | [»] | |
4J8N | X-ray | 3.14 | A/B/C/D | 123-401 | [»] | |
4JAI | X-ray | 3.20 | A | 122-396 | [»] | |
4JAJ | X-ray | 2.70 | A | 122-396 | [»] | |
4JBO | X-ray | 2.49 | A | 123-401 | [»] | |
4JBP | X-ray | 2.45 | A | 123-401 | [»] | |
4JBQ | X-ray | 2.30 | A | 123-401 | [»] | |
4O0S | X-ray | 2.50 | A | 122-403 | [»] | |
4O0U | X-ray | 2.60 | A | 122-403 | [»] | |
4O0W | X-ray | 2.60 | A | 122-403 | [»] | |
4PRJ | X-ray | 2.80 | A | 124-391 | [»] | |
4UYN | X-ray | 1.90 | A | 125-399 | [»] | |
4UZD | X-ray | 3.20 | A/B | 125-399 | [»] | |
4UZH | X-ray | 2.00 | A | 125-399 | [»] | |
4ZS0 | X-ray | 3.00 | A | 122-403 | [»] | |
4ZTQ | X-ray | 2.80 | A | 122-403 | [»] | |
4ZTR | X-ray | 2.85 | A | 122-403 | [»] | |
4ZTS | X-ray | 2.90 | A | 122-403 | [»] | |
5AAD | X-ray | 3.10 | A | 122-403 | [»] | |
5AAE | X-ray | 3.11 | A | 122-403 | [»] | |
5AAF | X-ray | 2.78 | A | 122-403 | [»] | |
5AAG | X-ray | 2.85 | A | 122-403 | [»] | |
5DN3 | X-ray | 2.05 | A | 125-391 | [»] | |
5DNR | X-ray | 1.95 | A | 125-391 | [»] | |
5DOS | X-ray | 2.98 | A | 126-390 | [»] | |
5DPV | X-ray | 2.29 | A | 126-390 | [»] | |
5DR2 | X-ray | 2.46 | A | 128-390 | [»] | |
5DR6 | X-ray | 2.53 | A | 126-390 | [»] | |
5DR9 | X-ray | 2.47 | A | 126-390 | [»] | |
5DRD | X-ray | 2.13 | A | 126-390 | [»] | |
5DT0 | X-ray | 2.15 | A | 126-390 | [»] | |
5DT3 | X-ray | 2.33 | A | 126-390 | [»] | |
5DT4 | X-ray | 2.86 | A | 126-390 | [»] | |
5EW9 | X-ray | 2.18 | A | 123-390 | [»] | |
5G15 | X-ray | 2.06 | A | 122-403 | [»] | |
5G1X | X-ray | 1.72 | A | 122-403 | [»] | |
5L8J | X-ray | 1.68 | A | 122-403 | [»] | |
5L8K | X-ray | 1.79 | A | 122-403 | [»] | |
5L8L | X-ray | 1.67 | A | 122-403 | [»] | |
5LXM | X-ray | 2.08 | A | 122-403 | [»] | |
5OBJ | X-ray | 2.90 | A | 125-391 | [»] | |
5OBR | X-ray | 2.62 | A | 125-391 | [»] | |
5ODT | X-ray | 2.02 | A | 122-403 | [»] | |
5ONE | X-ray | 2.60 | A | 122-403 | [»] | |
5ORL | X-ray | 1.69 | A | 127-391 | [»] | |
5ORN | X-ray | 2.19 | A | 127-391 | [»] | |
5ORO | X-ray | 2.12 | A | 127-391 | [»] | |
5ORP | X-ray | 2.19 | A | 127-391 | [»] | |
5ORR | X-ray | 2.09 | A | 127-391 | [»] | |
5ORS | X-ray | 1.98 | A | 127-391 | [»] | |
5ORT | X-ray | 2.56 | A | 127-391 | [»] | |
5ORV | X-ray | 1.88 | A | 127-391 | [»] | |
5ORW | X-ray | 2.00 | A | 127-391 | [»] | |
5ORX | X-ray | 1.88 | A | 127-391 | [»] | |
5ORY | X-ray | 1.99 | A | 127-391 | [»] | |
5ORZ | X-ray | 1.92 | A | 127-391 | [»] | |
5OS0 | X-ray | 1.74 | A | 127-391 | [»] | |
5OS1 | X-ray | 1.90 | A | 127-391 | [»] | |
5OS2 | X-ray | 1.92 | A | 127-391 | [»] | |
5OS3 | X-ray | 1.81 | A | 127-391 | [»] | |
5OS4 | X-ray | 1.88 | A | 127-391 | [»] | |
5OS5 | X-ray | 1.74 | A | 125-392 | [»] | |
5OS6 | X-ray | 2.20 | A | 127-391 | [»] | |
5OSD | X-ray | 1.99 | A | 125-391 | [»] | |
5OSE | X-ray | 1.90 | A | 127-391 | [»] | |
5OSF | X-ray | 1.89 | A | 127-391 | [»] | |
5ZAN | X-ray | 2.85 | A | 123-403 | [»] | |
6C2R | X-ray | 1.96 | A | 125-391 | [»] | |
6C2T | X-ray | 1.73 | A | 125-391 | [»] | |
6C83 | X-ray | 2.55 | A/B | 122-403 | [»] | |
6CPE | X-ray | 2.45 | A | 122-403 | [»] | |
6CPF | X-ray | 2.30 | A | 122-403 | [»] | |
6CPG | X-ray | 2.80 | A/D | 122-403 | [»] | |
6GRA | X-ray | 2.60 | A | 122-403 | [»] | |
6HJJ | X-ray | 2.13 | A | 122-403 | [»] | |
6HJK | X-ray | 2.40 | A | 122-403 | [»] | |
6I2U | X-ray | 2.50 | A | 122-403 | [»] | |
6R49 | X-ray | 2.21 | A | 122-403 | [»] | |
6R4A | X-ray | 1.94 | A | 122-403 | [»] | |
6R4B | X-ray | 2.15 | A | 122-403 | [»] | |
6R4C | X-ray | 2.04 | A | 122-403 | [»] | |
6R4D | X-ray | 2.01 | A | 122-403 | [»] | |
6VPG | X-ray | 2.64 | A | 117-389 | [»] | |
6VPH | X-ray | 2.14 | A | 117-389 | [»] | |
6VPI | X-ray | 2.00 | A | 117-389 | [»] | |
6VPJ | X-ray | 2.10 | A | 117-389 | [»] | |
6VPL | X-ray | 1.86 | A/B | 117-389 | [»] | |
6VPM | X-ray | 1.58 | A/B | 117-389 | [»] | |
6XKA | X-ray | 2.65 | A | 117-389 | [»] | |
6Z4Y | X-ray | 2.25 | A | 122-403 | [»] | |
7AYH | X-ray | 2.80 | A | 122-403 | [»] | |
7AYI | X-ray | 2.86 | A | 122-403 | [»] | |
7O2V | X-ray | 3.10 | A | 116-403 | [»] | |
SMRi | O14965 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112666, 422 interactors |
CORUMi | O14965 |
DIPi | DIP-33068N |
ELMi | O14965 |
IntActi | O14965, 175 interactors |
MINTi | O14965 |
STRINGi | 9606.ENSP00000216911 |
Chemistry databases
BindingDBi | O14965 |
ChEMBLi | CHEMBL4722 |
DrugBanki | DB07362, 1-(5-{2-[(1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)amino]ethyl}-1,3-thiazol-2-yl)-3-[3-(trifluoromethyl)phenyl]urea DB07360, 1-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}-3-[3-(trifluoromethyl)phenyl]urea DB08065, 2-(1H-pyrazol-3-yl)-1H-benzimidazole DB07186, 4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE DB07266, AKI-001 DB05220, Alisertib DB05169, AT9283 DB06347, Cenisertib DB05198, CYC116 DB06486, Enzastaurin DB12010, Fostamatinib DB13061, MLN8054 DB08066, N-[3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRAZOL-4-YL]BENZAMIDE DB07801, N-butyl-3-{[6-(9H-purin-6-ylamino)hexanoyl]amino}benzamide DB07545, N-{3-[(4-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMIDIN-2-YL)AMINO]PHENYL}CYCLOPROPANECARBOXAMIDE DB02482, Phosphonothreonine DB06134, SNS-314 |
DrugCentrali | O14965 |
GuidetoPHARMACOLOGYi | 1936 |
PTM databases
iPTMneti | O14965 |
PhosphoSitePlusi | O14965 |
Genetic variation databases
BioMutai | AURKA |
Proteomic databases
CPTACi | CPTAC-1341 |
EPDi | O14965 |
jPOSTi | O14965 |
MassIVEi | O14965 |
MaxQBi | O14965 |
PaxDbi | O14965 |
PeptideAtlasi | O14965 |
PRIDEi | O14965 |
ProteomicsDBi | 48339 |
Protocols and materials databases
ABCDi | O14965, 1 sequenced antibody |
Antibodypediai | 1129, 1065 antibodies from 46 providers |
DNASUi | 6790 |
Genome annotation databases
Organism-specific databases
CTDi | 6790 |
DisGeNETi | 6790 |
GeneCardsi | AURKA |
HGNCi | HGNC:11393, AURKA |
HPAi | ENSG00000087586, Tissue enhanced (lymphoid tissue, testis) |
MalaCardsi | AURKA |
MIMi | 603072, gene |
neXtProti | NX_O14965 |
PharmGKBi | PA36201 |
VEuPathDBi | HostDB:ENSG00000087586 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0580, Eukaryota |
InParanoidi | O14965 |
OrthoDBi | 954262at2759 |
PhylomeDBi | O14965 |
TreeFami | TF105331 |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 2681 |
PathwayCommonsi | O14965 |
Reactomei | R-HSA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition R-HSA-4615885, SUMOylation of DNA replication proteins R-HSA-6804114, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation R-HSA-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8854518, AURKA Activation by TPX2 R-HSA-8854521, Interaction between PHLDA1 and AURKA |
SignaLinki | O14965 |
SIGNORi | O14965 |
Miscellaneous databases
BioGRID-ORCSi | 6790, 678 hits in 1090 CRISPR screens |
ChiTaRSi | AURKA, human |
EvolutionaryTracei | O14965 |
GeneWikii | Aurora_A_kinase |
GenomeRNAii | 6790 |
Pharosi | O14965, Tchem |
PROi | PR:O14965 |
RNActi | O14965, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000087586, Expressed in oocyte and 190 other tissues |
ExpressionAtlasi | O14965, baseline and differential |
Genevisiblei | O14965, HS |
Family and domain databases
CDDi | cd14116, STKc_Aurora-A, 1 hit |
InterProi | View protein in InterPro IPR030616, Aur IPR030611, AURKA IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
PANTHERi | PTHR24350, PTHR24350, 1 hit |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AURKA_HUMAN | |
Accessioni | O14965Primary (citable) accession number: O14965 Secondary accession number(s): E1P5F9 Q9UPG5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 27, 2003 |
Last sequence update: | February 23, 2022 | |
Last modified: | February 23, 2022 | |
This is version 235 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families