UniProtKB - O14960 (LECT2_HUMAN)
Protein
Leukocyte cell-derived chemotaxin-2
Gene
LECT2
Organism
Homo sapiens (Human)
Status
Functioni
Has a neutrophil chemotactic activity. Also a positive regulator of chondrocyte proliferation (PubMed:9524238). Does not show metalloendopeptidase activity (PubMed:27334921).2 Publications
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 53 | ZincCombined sources1 Publication | 1 | |
Metal bindingi | 57 | ZincCombined sources1 Publication | 1 | |
Metal bindingi | 138 | ZincCombined sources1 Publication | 1 |
GO - Molecular functioni
- identical protein binding Source: IntAct
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- chemotaxis Source: ProtInc
- skeletal system development Source: ProtInc
Keywordsi
Biological process | Chemotaxis |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | O14960 |
Names & Taxonomyi
Protein namesi | Recommended name: Leukocyte cell-derived chemotaxin-2Short name: LECT-2 Short name: hLECT2 |
Gene namesi | Name:LECT2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6550, LECT2 |
MIMi | 602882, gene |
neXtProti | NX_O14960 |
VEuPathDBi | HostDB:ENSG00000145826.8 |
Subcellular locationi
Extracellular region or secreted
- extracellular space Source: ProtInc
Other locations
- cytoplasm Source: ProtInc
Keywords - Cellular componenti
Cytoplasm, SecretedPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 104 | Y → H: No metalloendopeptidase activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 3950 |
OpenTargetsi | ENSG00000145826 |
PharmGKBi | PA30330 |
Miscellaneous databases
Pharosi | O14960, Tbio |
Genetic variation databases
BioMutai | LECT2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | By similarityAdd BLAST | 18 | |
ChainiPRO_0000017364 | 19 – 151 | Leukocyte cell-derived chemotaxin-2Add BLAST | 133 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 25 ↔ 60 | Combined sources2 Publications | ||
Disulfide bondi | 36 ↔ 41 | Combined sources2 Publications | ||
Disulfide bondi | 99 ↔ 142 | Combined sources2 Publications |
Keywords - PTMi
Disulfide bondProteomic databases
MassIVEi | O14960 |
PaxDbi | O14960 |
PeptideAtlasi | O14960 |
PRIDEi | O14960 |
ProteomicsDBi | 48336 |
PTM databases
PhosphoSitePlusi | O14960 |
Expressioni
Tissue specificityi
Highly expressed in adult and fetal liver and weakly in testis. Not expressed in bone marrow.2 Publications
Inductioni
By phytohemagglutinin (PHA).1 Publication
Gene expression databases
Bgeei | ENSG00000145826, Expressed in liver and 108 other tissues |
ExpressionAtlasi | O14960, baseline and differential |
Genevisiblei | O14960, HS |
Organism-specific databases
HPAi | ENSG00000145826, Tissue enriched (liver) |
Interactioni
Subunit structurei
Interacts with MET.
1 PublicationBinary interactionsi
O14960
With | #Exp. | IntAct |
---|---|---|
itself | 3 | EBI-8307271,EBI-8307271 |
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 110142, 2 interactors |
IntActi | O14960, 2 interactors |
MINTi | O14960 |
STRINGi | 9606.ENSP00000274507 |
Miscellaneous databases
RNActi | O14960, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | O14960 |
SMRi | O14960 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the LECT2/MIM-1 family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S16D, Eukaryota |
GeneTreei | ENSGT00390000015484 |
InParanoidi | O14960 |
OMAi | HRPHQGV |
OrthoDBi | 1298781at2759 |
PhylomeDBi | O14960 |
TreeFami | TF331097 |
Family and domain databases
Gene3Di | 2.70.70.10, 1 hit |
InterProi | View protein in InterPro IPR011055, Dup_hybrid_motif IPR008663, LECT2 IPR017381, LECT2_chordata IPR016047, Peptidase_M23 |
PANTHERi | PTHR11329, PTHR11329, 1 hit |
Pfami | View protein in Pfam PF01551, Peptidase_M23, 1 hit |
PIRSFi | PIRSF038085, LECT3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
O14960-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFSTKALLLA GLISTALAGP WANICAGKSS NEIRTCDRHG CGQYSAQRSQ
60 70 80 90 100
RPHQGVDILC SAGSTVYAPF TGMIVGQEKP YQNKNAINNG VRISGRGFCV
110 120 130 140 150
KMFYIKPIKY KGPIKKGEKL GTLLPLQKVY PGIQSHVHIE NCDSSDPTAY
L
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6RGX8 | D6RGX8_HUMAN | Leukocyte cell-derived chemotaxin-2 | LECT2 | 111 | Annotation score: | ||
E5RHW6 | E5RHW6_HUMAN | Leukocyte cell-derived chemotaxin-2 | LECT2 | 131 | Annotation score: | ||
D6RD58 | D6RD58_HUMAN | Leukocyte cell-derived chemotaxin-2 | LECT2 | 79 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_011386 | 58 | I → V6 PublicationsCorresponds to variant dbSNP:rs31517Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D63521 mRNA Translation: BAA23609.1 AB007546 Genomic DNA Translation: BAA25669.1 AK314092 mRNA Translation: BAG36787.1 AC004763 Genomic DNA Translation: AAC17734.1 AC002428 Genomic DNA Translation: AAB66905.1 BC093670 mRNA Translation: AAH93670.1 BC101579 mRNA Translation: AAI01580.1 |
CCDSi | CCDS4190.1 |
RefSeqi | NP_002293.2, NM_002302.2 |
Genome annotation databases
Ensembli | ENST00000274507; ENSP00000274507; ENSG00000145826 |
GeneIDi | 3950 |
KEGGi | hsa:3950 |
UCSCi | uc003lbe.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D63521 mRNA Translation: BAA23609.1 AB007546 Genomic DNA Translation: BAA25669.1 AK314092 mRNA Translation: BAG36787.1 AC004763 Genomic DNA Translation: AAC17734.1 AC002428 Genomic DNA Translation: AAB66905.1 BC093670 mRNA Translation: AAH93670.1 BC101579 mRNA Translation: AAI01580.1 |
CCDSi | CCDS4190.1 |
RefSeqi | NP_002293.2, NM_002302.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5B0H | X-ray | 1.94 | A/B | 19-151 | [»] | |
BMRBi | O14960 | |||||
SMRi | O14960 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110142, 2 interactors |
IntActi | O14960, 2 interactors |
MINTi | O14960 |
STRINGi | 9606.ENSP00000274507 |
PTM databases
PhosphoSitePlusi | O14960 |
Genetic variation databases
BioMutai | LECT2 |
Proteomic databases
MassIVEi | O14960 |
PaxDbi | O14960 |
PeptideAtlasi | O14960 |
PRIDEi | O14960 |
ProteomicsDBi | 48336 |
Protocols and materials databases
Antibodypediai | 26441, 271 antibodies |
Genome annotation databases
Ensembli | ENST00000274507; ENSP00000274507; ENSG00000145826 |
GeneIDi | 3950 |
KEGGi | hsa:3950 |
UCSCi | uc003lbe.1, human |
Organism-specific databases
CTDi | 3950 |
DisGeNETi | 3950 |
GeneCardsi | LECT2 |
HGNCi | HGNC:6550, LECT2 |
HPAi | ENSG00000145826, Tissue enriched (liver) |
MIMi | 602882, gene |
neXtProti | NX_O14960 |
OpenTargetsi | ENSG00000145826 |
PharmGKBi | PA30330 |
VEuPathDBi | HostDB:ENSG00000145826.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S16D, Eukaryota |
GeneTreei | ENSGT00390000015484 |
InParanoidi | O14960 |
OMAi | HRPHQGV |
OrthoDBi | 1298781at2759 |
PhylomeDBi | O14960 |
TreeFami | TF331097 |
Enzyme and pathway databases
PathwayCommonsi | O14960 |
Miscellaneous databases
BioGRID-ORCSi | 3950, 4 hits in 872 CRISPR screens |
GeneWikii | LECT2 |
GenomeRNAii | 3950 |
Pharosi | O14960, Tbio |
PROi | PR:O14960 |
RNActi | O14960, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000145826, Expressed in liver and 108 other tissues |
ExpressionAtlasi | O14960, baseline and differential |
Genevisiblei | O14960, HS |
Family and domain databases
Gene3Di | 2.70.70.10, 1 hit |
InterProi | View protein in InterPro IPR011055, Dup_hybrid_motif IPR008663, LECT2 IPR017381, LECT2_chordata IPR016047, Peptidase_M23 |
PANTHERi | PTHR11329, PTHR11329, 1 hit |
Pfami | View protein in Pfam PF01551, Peptidase_M23, 1 hit |
PIRSFi | PIRSF038085, LECT3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LECT2_HUMAN | |
Accessioni | O14960Primary (citable) accession number: O14960 Secondary accession number(s): B2RA90, O14565, Q52M49 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | January 11, 2011 | |
Last modified: | February 10, 2021 | |
This is version 147 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families