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Protein

Leukocyte cell-derived chemotaxin-2

Gene

LECT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has a neutrophil chemotactic activity. Also a positive regulator of chondrocyte proliferation (PubMed:9524238). Does not show metalloendopeptidase activity (PubMed:27334921).2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi53ZincCombined sources1 Publication1
Metal bindingi57ZincCombined sources1 Publication1
Metal bindingi138ZincCombined sources1 Publication1

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • chemotaxis Source: ProtInc
  • skeletal system development Source: ProtInc

Keywordsi

Biological processChemotaxis
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte cell-derived chemotaxin-2
Short name:
LECT-2
Short name:
hLECT2
Gene namesi
Name:LECT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000145826.8
HGNCiHGNC:6550 LECT2
MIMi602882 gene
neXtProtiNX_O14960

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi104Y → H: No metalloendopeptidase activity. 1 Publication1

Organism-specific databases

DisGeNETi3950
OpenTargetsiENSG00000145826
PharmGKBiPA30330

Polymorphism and mutation databases

BioMutaiLECT2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
ChainiPRO_000001736419 – 151Leukocyte cell-derived chemotaxin-2Add BLAST133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 60Combined sources2 Publications
Disulfide bondi36 ↔ 41Combined sources2 Publications
Disulfide bondi99 ↔ 142Combined sources2 Publications

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO14960
PeptideAtlasiO14960
PRIDEiO14960
ProteomicsDBi48336

PTM databases

PhosphoSitePlusiO14960

Expressioni

Tissue specificityi

Highly expressed in adult and fetal liver and weakly in testis. Not expressed in bone marrow.2 Publications

Inductioni

By phytohemagglutinin (PHA).1 Publication

Gene expression databases

BgeeiENSG00000145826 Expressed in 81 organ(s), highest expression level in liver
CleanExiHS_LECT2
ExpressionAtlasiO14960 baseline and differential
GenevisibleiO14960 HS

Organism-specific databases

HPAiHPA043883

Interactioni

Subunit structurei

Interacts with MET.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-8307271,EBI-8307271

GO - Molecular functioni

Protein-protein interaction databases

MINTiO14960
STRINGi9606.ENSP00000274507

Structurei

Secondary structure

1151
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO14960
SMRiO14960
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LECT2/MIM-1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJ84 Eukaryota
ENOG410XVAU LUCA
GeneTreeiENSGT00390000015484
HOGENOMiHOG000113312
HOVERGENiHBG052320
InParanoidiO14960
OMAiSHGCGQY
OrthoDBiEOG091G0B4B
PhylomeDBiO14960
TreeFamiTF331097

Family and domain databases

Gene3Di2.70.70.10, 1 hit
InterProiView protein in InterPro
IPR011055 Dup_hybrid_motif
IPR008663 LECT2
IPR017381 LECT2_chordata
IPR016047 Peptidase_M23
PANTHERiPTHR11329 PTHR11329, 1 hit
PfamiView protein in Pfam
PF01551 Peptidase_M23, 1 hit
PIRSFiPIRSF038085 LECT3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O14960-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFSTKALLLA GLISTALAGP WANICAGKSS NEIRTCDRHG CGQYSAQRSQ
60 70 80 90 100
RPHQGVDILC SAGSTVYAPF TGMIVGQEKP YQNKNAINNG VRISGRGFCV
110 120 130 140 150
KMFYIKPIKY KGPIKKGEKL GTLLPLQKVY PGIQSHVHIE NCDSSDPTAY

L
Length:151
Mass (Da):16,390
Last modified:January 11, 2011 - v2
Checksum:i3C1DFCA1B4F8792F
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RGX8D6RGX8_HUMAN
Leukocyte cell-derived chemotaxin-2
LECT2
111Annotation score:
E5RHW6E5RHW6_HUMAN
Leukocyte cell-derived chemotaxin-2
LECT2
131Annotation score:
D6RD58D6RD58_HUMAN
Leukocyte cell-derived chemotaxin-2
LECT2
79Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01138658I → V6 PublicationsCorresponds to variant dbSNP:rs31517Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63521 mRNA Translation: BAA23609.1
AB007546 Genomic DNA Translation: BAA25669.1
AK314092 mRNA Translation: BAG36787.1
AC004763 Genomic DNA Translation: AAC17734.1
AC002428 Genomic DNA Translation: AAB66905.1
BC093670 mRNA Translation: AAH93670.1
BC101579 mRNA Translation: AAI01580.1
CCDSiCCDS4190.1
RefSeqiNP_002293.2, NM_002302.2
UniGeneiHs.512580

Genome annotation databases

EnsembliENST00000274507; ENSP00000274507; ENSG00000145826
GeneIDi3950
KEGGihsa:3950
UCSCiuc003lbe.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63521 mRNA Translation: BAA23609.1
AB007546 Genomic DNA Translation: BAA25669.1
AK314092 mRNA Translation: BAG36787.1
AC004763 Genomic DNA Translation: AAC17734.1
AC002428 Genomic DNA Translation: AAB66905.1
BC093670 mRNA Translation: AAH93670.1
BC101579 mRNA Translation: AAI01580.1
CCDSiCCDS4190.1
RefSeqiNP_002293.2, NM_002302.2
UniGeneiHs.512580

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5B0HX-ray1.94A/B19-151[»]
ProteinModelPortaliO14960
SMRiO14960
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiO14960
STRINGi9606.ENSP00000274507

PTM databases

PhosphoSitePlusiO14960

Polymorphism and mutation databases

BioMutaiLECT2

Proteomic databases

PaxDbiO14960
PeptideAtlasiO14960
PRIDEiO14960
ProteomicsDBi48336

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274507; ENSP00000274507; ENSG00000145826
GeneIDi3950
KEGGihsa:3950
UCSCiuc003lbe.1 human

Organism-specific databases

CTDi3950
DisGeNETi3950
EuPathDBiHostDB:ENSG00000145826.8
GeneCardsiLECT2
H-InvDBiHIX0032112
HGNCiHGNC:6550 LECT2
HPAiHPA043883
MIMi602882 gene
neXtProtiNX_O14960
OpenTargetsiENSG00000145826
PharmGKBiPA30330
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ84 Eukaryota
ENOG410XVAU LUCA
GeneTreeiENSGT00390000015484
HOGENOMiHOG000113312
HOVERGENiHBG052320
InParanoidiO14960
OMAiSHGCGQY
OrthoDBiEOG091G0B4B
PhylomeDBiO14960
TreeFamiTF331097

Miscellaneous databases

GeneWikiiLECT2
GenomeRNAii3950
PROiPR:O14960
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000145826 Expressed in 81 organ(s), highest expression level in liver
CleanExiHS_LECT2
ExpressionAtlasiO14960 baseline and differential
GenevisibleiO14960 HS

Family and domain databases

Gene3Di2.70.70.10, 1 hit
InterProiView protein in InterPro
IPR011055 Dup_hybrid_motif
IPR008663 LECT2
IPR017381 LECT2_chordata
IPR016047 Peptidase_M23
PANTHERiPTHR11329 PTHR11329, 1 hit
PfamiView protein in Pfam
PF01551 Peptidase_M23, 1 hit
PIRSFiPIRSF038085 LECT3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLECT2_HUMAN
AccessioniPrimary (citable) accession number: O14960
Secondary accession number(s): B2RA90, O14565, Q52M49
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 11, 2011
Last modified: November 7, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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