LECT2

Functionⁱ

Has a neutrophil chemotactic activity. Also a positive regulator of chondrocyte proliferation (PubMed:9524238). Does not show metalloendopeptidase activity (PubMed:27334921).2 Publications

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	53	ZincCombined sources1 Publication	1
Metal bindingⁱ	57	ZincCombined sources1 Publication	1
Metal bindingⁱ	138	ZincCombined sources1 Publication	1

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 23352894
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

chemotaxis
Source: ProtInc
Traceable author statementⁱ
- 8877413
skeletal system development
Source: ProtInc
Traceable author statementⁱ
- 9545637

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Chemotaxis
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Leukocyte cell-derived chemotaxin-2 Short name: LECT-2 Short name: hLECT2
Gene namesⁱ	Name:LECT2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000145826.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6550 LECT2
MIMⁱ	602882 gene
neXtProtⁱ	NX_O14960

Keywords - Cellular componentⁱ

Cytoplasm, Secreted

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	104	Y → H: No metalloendopeptidase activity. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3950
Open Targets More...OpenTargetsⁱ	ENSG00000145826
PharmGKBⁱ	PA30330

Polymorphism and mutation databases

BioMutaⁱ	LECT2

BioMutaⁱ

LECT2

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 18	By similarityAdd BLAST		18
ChainⁱPRO_0000017364	19 – 151	Leukocyte cell-derived chemotaxin-2Add BLAST		133

Amino acid modifications

Feature key	Position(s)	DescriptionActions
Disulfide bondⁱ	25 ↔ 60	Combined sources2 Publications
Disulfide bondⁱ	36 ↔ 41	Combined sources2 Publications
Disulfide bondⁱ	99 ↔ 142	Combined sources2 Publications

Keywords - PTMⁱ

Disulfide bond

Proteomic databases

PaxDbⁱ	O14960
PeptideAtlas More...PeptideAtlasⁱ	O14960
PRIDEⁱ	O14960
ProteomicsDBⁱ	48336

PTM databases

PhosphoSitePlusⁱ	O14960

PhosphoSitePlusⁱ

O14960

Expressionⁱ

Tissue specificityⁱ

Highly expressed in adult and fetal liver and weakly in testis. Not expressed in bone marrow.2 Publications

Inductionⁱ

By phytohemagglutinin (PHA).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000145826 Expressed in 81 organ(s), highest expression level in liver
CleanExⁱ	HS_LECT2
ExpressionAtlasⁱ	O14960 baseline and differential
Genevisibleⁱ	O14960 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA043883

HPAⁱ

HPA043883

Interactionⁱ

Subunit structureⁱ

Interacts with MET.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
itself		3	EBI-8307271,EBI-8307271

With

Entry

#Exp.

IntAct

Notes

itself

3

EBI-8307271,EBI-8307271

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 23352894

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

Molecular INTeraction database More...MINTⁱ	O14960
STRINGⁱ	9606.ENSP00000274507

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	49 – 51	Combined sources	3
Beta strandⁱ	55 – 59	Combined sources	5
Beta strandⁱ	65 – 67	Combined sources	3
Beta strandⁱ	69 – 77	Combined sources	9
Beta strandⁱ	90 – 95	Combined sources	6
Beta strandⁱ	98 – 108	Combined sources	11
Beta strandⁱ	110 – 114	Combined sources	5
Beta strandⁱ	118 – 123	Combined sources	6
Helixⁱ	126 – 129	Combined sources	4
Beta strandⁱ	136 – 141	Combined sources	6
Helixⁱ	148 – 150	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	O14960
SMRⁱ	O14960
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the LECT2/MIM-1 family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IJ84 Eukaryota ENOG410XVAU LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000015484
HOGENOMⁱ	HOG000113312
HOVERGENⁱ	HBG052320
InParanoidⁱ	O14960
OMAⁱ	SHGCGQY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0B4B
PhylomeDBⁱ	O14960
TreeFamⁱ	TF331097

Family and domain databases

Gene3Dⁱ	2.70.70.10, 1 hit
InterProⁱ	View protein in InterPro IPR011055 Dup_hybrid_motif IPR008663 LECT2 IPR017381 LECT2_chordata IPR016047 Peptidase_M23
PANTHERⁱ	PTHR11329 PTHR11329, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01551 Peptidase_M23, 1 hit
PIRSFⁱ	PIRSF038085 LECT3, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

O14960-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MFSTKALLLA GLISTALAGP WANICAGKSS NEIRTCDRHG CGQYSAQRSQ 
        60         70         80         90        100
RPHQGVDILC SAGSTVYAPF TGMIVGQEKP YQNKNAINNG VRISGRGFCV 
       110        120        130        140        150
KMFYIKPIKY KGPIKKGEKL GTLLPLQKVY PGIQSHVHIE NCDSSDPTAY 

L

Length:151

Mass (Da):16,390

Last modified:January 11, 2011 - v2

Checksum:ⁱ3C1DFCA1B4F8792F

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D6RGX8	D6RGX8_HUMAN	Leukocyte cell-derived chemotaxin-2 Leukocyte cell-derived chemotaxin-2	LECT2	111	Annotation score:
E5RHW6	E5RHW6_HUMAN	Leukocyte cell-derived chemotaxin-2 Leukocyte cell-derived chemotaxin-2	LECT2	131	Annotation score:
D6RD58	D6RD58_HUMAN	Leukocyte cell-derived chemotaxin-2 Leukocyte cell-derived chemotaxin-2	LECT2	79	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_011386	58	I → V6 PublicationsCorresponds to variant dbSNP:rs31517Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D63521 mRNA Translation: BAA23609.1 AB007546 Genomic DNA Translation: BAA25669.1 AK314092 mRNA Translation: BAG36787.1 AC004763 Genomic DNA Translation: AAC17734.1 AC002428 Genomic DNA Translation: AAB66905.1 BC093670 mRNA Translation: AAH93670.1 BC101579 mRNA Translation: AAI01580.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4190.1
NCBI Reference Sequences More...RefSeqⁱ	NP_002293.2, NM_002302.2
UniGeneⁱ	Hs.512580

Genome annotation databases

Ensemblⁱ	ENST00000274507; ENSP00000274507; ENSG00000145826
GeneIDⁱ	3950
KEGGⁱ	hsa:3950
UCSC genome browser More...UCSCⁱ	uc003lbe.1 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O14960	Leukocyte cell derived chemotaxin 2		GORGO		151	UniRef100_O14960
Leukocyte cell-derived chemotaxin-2		HUMAN		79
LECT2 isoform 4		PONAB		79
LECT2 isoform 4		PANTR		79

Protein	Similar proteins		Species	Score	Length	Source
O14960	Leukocyte cell derived chemotaxin 2		GORGO		151	UniRef90_O14960
Leukocyte cell-derived chemotaxin-2		HUMAN		79
LECT2 isoform 4		PONAB		79
LECT2 isoform 4		PANTR		79
Leukocyte cell derived chemotaxin 2		MACMU		151
+22

Protein	Similar proteins		Species	Score	Length	Source
O14960	Leukocyte cell-derived chemotaxin-2		MOUSE		151	UniRef50_O14960
Leukocyte cell-derived chemotaxin-2		BOVIN		151
Leukocyte cell derived chemotaxin 2		GORGO		151
Leukocyte cell-derived chemotaxin-2		HUMAN		79
LECT2 isoform 4		PONAB		79
+108

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D63521 mRNA Translation: BAA23609.1 AB007546 Genomic DNA Translation: BAA25669.1 AK314092 mRNA Translation: BAG36787.1 AC004763 Genomic DNA Translation: AAC17734.1 AC002428 Genomic DNA Translation: AAB66905.1 BC093670 mRNA Translation: AAH93670.1 BC101579 mRNA Translation: AAI01580.1
CCDSⁱ	CCDS4190.1
RefSeqⁱ	NP_002293.2, NM_002302.2
UniGeneⁱ	Hs.512580

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5B0H	X-ray	1.94	A/B	19-151	[»]
ProteinModelPortalⁱ	O14960
SMRⁱ	O14960
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

MINTⁱ	O14960
STRINGⁱ	9606.ENSP00000274507

PTM databases

PhosphoSitePlusⁱ	O14960

PhosphoSitePlusⁱ

O14960

Polymorphism and mutation databases

BioMutaⁱ	LECT2

BioMutaⁱ

LECT2

Proteomic databases

PaxDbⁱ	O14960
PeptideAtlasⁱ	O14960
PRIDEⁱ	O14960
ProteomicsDBⁱ	48336

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000274507; ENSP00000274507; ENSG00000145826
GeneIDⁱ	3950
KEGGⁱ	hsa:3950
UCSCⁱ	uc003lbe.1 human

Organism-specific databases

CTDⁱ	3950
DisGeNETⁱ	3950
EuPathDBⁱ	HostDB:ENSG00000145826.8
GeneCardsⁱ	LECT2
H-InvDBⁱ	HIX0032112
HGNCⁱ	HGNC:6550 LECT2
HPAⁱ	HPA043883
MIMⁱ	602882 gene
neXtProtⁱ	NX_O14960
OpenTargetsⁱ	ENSG00000145826
PharmGKBⁱ	PA30330
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IJ84 Eukaryota ENOG410XVAU LUCA
GeneTreeⁱ	ENSGT00390000015484
HOGENOMⁱ	HOG000113312
HOVERGENⁱ	HBG052320
InParanoidⁱ	O14960
OMAⁱ	SHGCGQY
OrthoDBⁱ	EOG091G0B4B
PhylomeDBⁱ	O14960
TreeFamⁱ	TF331097

Miscellaneous databases

GeneWikiⁱ	LECT2
GenomeRNAiⁱ	3950
Protein Ontology More...PROⁱ	PR:O14960
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000145826 Expressed in 81 organ(s), highest expression level in liver
CleanExⁱ	HS_LECT2
ExpressionAtlasⁱ	O14960 baseline and differential
Genevisibleⁱ	O14960 HS

Family and domain databases

Gene3Dⁱ	2.70.70.10, 1 hit
InterProⁱ	View protein in InterPro IPR011055 Dup_hybrid_motif IPR008663 LECT2 IPR017381 LECT2_chordata IPR016047 Peptidase_M23
PANTHERⁱ	PTHR11329 PTHR11329, 1 hit
Pfamⁱ	View protein in Pfam PF01551 Peptidase_M23, 1 hit
PIRSFⁱ	PIRSF038085 LECT3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LECT2_HUMAN
Accessionⁱ	O14960Primary (citable) accession number: O14960 Secondary accession number(s): B2RA90, O14565, Q52M49
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
	Last sequence update:	January 11, 2011
	Last modified:	November 7, 2018
	This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM

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UniProtKB - O14960 (LECT2_HUMAN)

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Leukocyte cell-derived chemotaxin-2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Other locations

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ