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Protein

Cytochrome b-c1 complex subunit 10

Gene

UQCR11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain.
This protein may be closely linked to the iron-sulfur protein in the complex and function as an iron-sulfur protein binding factor.

GO - Molecular functioni

  • electron transfer activity Source: UniProtKB
  • ubiquinol-cytochrome-c reductase activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-HSA-611105 Respiratory electron transport

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 10
Alternative name(s):
Complex III subunit 10
Complex III subunit XI
Ubiquinol-cytochrome c reductase complex 6.4 kDa protein
Gene namesi
Name:UQCR11
Synonyms:UQCR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000127540.11
HGNCiHGNC:30862 UQCR11
MIMi609711 gene
neXtProtiNX_O14957

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10975
OpenTargetsiENSG00000127540
PharmGKBiPA165394505

Chemistry databases

DrugBankiDB08453 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE
DB07778 FAMOXADONE
DB07401 METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE
DB08330 METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE
DB08690 UBIQUINONE-2

Polymorphism and mutation databases

BioMutaiUQCR11

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001935601 – 56Cytochrome b-c1 complex subunit 10Add BLAST56

Proteomic databases

EPDiO14957
MaxQBiO14957
PaxDbiO14957
PeptideAtlasiO14957
PRIDEiO14957
ProteomicsDBi48334
TopDownProteomicsiO14957

Expressioni

Gene expression databases

BgeeiENSG00000127540 Expressed in 243 organ(s), highest expression level in endothelial cell
CleanExiHS_UQCR
GenevisibleiO14957 HS

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

Protein-protein interaction databases

BioGridi116172, 4 interactors
ComplexPortaliCPX-560 Mitochondrial respiratory chain complex III
IntActiO14957, 1 interactor
STRINGi9606.ENSP00000466420

Structurei

Secondary structure

156
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO14957
SMRiO14957
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UQCR11/QCR10 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J5Z0 Eukaryota
ENOG410XVMI LUCA
GeneTreeiENSGT00390000018299
HOGENOMiHOG000030914
HOVERGENiHBG105467
InParanoidiO14957
KOiK00420
OMAiRELAKNW
OrthoDBiEOG091G1ATB
PhylomeDBiO14957
TreeFamiTF105034

Family and domain databases

InterProiView protein in InterPro
IPR029027 Single_a-helix_sf
IPR015089 UQCR
PANTHERiPTHR15420 PTHR15420, 1 hit
PfamiView protein in Pfam
PF08997 UCR_6-4kD, 1 hit
SUPFAMiSSF81518 SSF81518, 1 hit

Sequencei

Sequence statusi: Complete.

O14957-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVTRFLGPRY RELVKNWVPT AYTWGAVGAV GLVWATDWRL ILDWVPYING

KFKKDN
Length:56
Mass (Da):6,570
Last modified:January 1, 1998 - v1
Checksum:i0AE1CB90A205112C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D55636 mRNA Translation: BAA21748.1
AK312053 mRNA Translation: BAG34989.1
AC005321 Genomic DNA Translation: AAC27374.1
AC005943 Genomic DNA Translation: AAC72105.1
CH471139 Genomic DNA Translation: EAW69474.1
CH471139 Genomic DNA Translation: EAW69475.1
CH471139 Genomic DNA Translation: EAW69476.1
BC000462 mRNA Translation: AAH00462.1
BC003594 mRNA Translation: AAH03594.1
CCDSiCCDS12073.1
RefSeqiNP_006821.1, NM_006830.3
UniGeneiHs.8372

Genome annotation databases

EnsembliENST00000585671; ENSP00000466420; ENSG00000127540
ENST00000589880; ENSP00000467555; ENSG00000127540
ENST00000591899; ENSP00000467262; ENSG00000127540
GeneIDi10975
KEGGihsa:10975
UCSCiuc002ltm.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D55636 mRNA Translation: BAA21748.1
AK312053 mRNA Translation: BAG34989.1
AC005321 Genomic DNA Translation: AAC27374.1
AC005943 Genomic DNA Translation: AAC72105.1
CH471139 Genomic DNA Translation: EAW69474.1
CH471139 Genomic DNA Translation: EAW69475.1
CH471139 Genomic DNA Translation: EAW69476.1
BC000462 mRNA Translation: AAH00462.1
BC003594 mRNA Translation: AAH03594.1
CCDSiCCDS12073.1
RefSeqiNP_006821.1, NM_006830.3
UniGeneiHs.8372

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XTEelectron microscopy3.40G/T2-52[»]
5XTHelectron microscopy3.90AG/AT2-52[»]
5XTIelectron microscopy17.40AG/AT2-52[»]
ProteinModelPortaliO14957
SMRiO14957
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116172, 4 interactors
ComplexPortaliCPX-560 Mitochondrial respiratory chain complex III
IntActiO14957, 1 interactor
STRINGi9606.ENSP00000466420

Chemistry databases

DrugBankiDB08453 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE
DB07778 FAMOXADONE
DB07401 METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE
DB08330 METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE
DB08690 UBIQUINONE-2

Polymorphism and mutation databases

BioMutaiUQCR11

Proteomic databases

EPDiO14957
MaxQBiO14957
PaxDbiO14957
PeptideAtlasiO14957
PRIDEiO14957
ProteomicsDBi48334
TopDownProteomicsiO14957

Protocols and materials databases

DNASUi10975
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000585671; ENSP00000466420; ENSG00000127540
ENST00000589880; ENSP00000467555; ENSG00000127540
ENST00000591899; ENSP00000467262; ENSG00000127540
GeneIDi10975
KEGGihsa:10975
UCSCiuc002ltm.4 human

Organism-specific databases

CTDi10975
DisGeNETi10975
EuPathDBiHostDB:ENSG00000127540.11
GeneCardsiUQCR11
HGNCiHGNC:30862 UQCR11
MIMi609711 gene
neXtProtiNX_O14957
OpenTargetsiENSG00000127540
PharmGKBiPA165394505
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J5Z0 Eukaryota
ENOG410XVMI LUCA
GeneTreeiENSGT00390000018299
HOGENOMiHOG000030914
HOVERGENiHBG105467
InParanoidiO14957
KOiK00420
OMAiRELAKNW
OrthoDBiEOG091G1ATB
PhylomeDBiO14957
TreeFamiTF105034

Enzyme and pathway databases

ReactomeiR-HSA-611105 Respiratory electron transport

Miscellaneous databases

ChiTaRSiUQCR11 human
GenomeRNAii10975
PROiPR:O14957
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000127540 Expressed in 243 organ(s), highest expression level in endothelial cell
CleanExiHS_UQCR
GenevisibleiO14957 HS

Family and domain databases

InterProiView protein in InterPro
IPR029027 Single_a-helix_sf
IPR015089 UQCR
PANTHERiPTHR15420 PTHR15420, 1 hit
PfamiView protein in Pfam
PF08997 UCR_6-4kD, 1 hit
SUPFAMiSSF81518 SSF81518, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQCR10_HUMAN
AccessioniPrimary (citable) accession number: O14957
Secondary accession number(s): B2R542
, D6W5Z4, Q9UEA3, Q9UPK4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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