UniProtKB - O14957 (QCR10_HUMAN)
Cytochrome b-c1 complex subunit 10
UQCR11
Functioni
GO - Molecular functioni
- electron transfer activity Source: UniProtKB
- ubiquinol-cytochrome-c reductase activity Source: GO_Central
GO - Biological processi
- generation of precursor metabolites and energy Source: ProtInc
- mitochondrial electron transport, ubiquinol to cytochrome c Source: Reactome
Keywordsi
Biological process | Electron transport, Respiratory chain, Transport |
Enzyme and pathway databases
BioCyci | MetaCyc:HS05111-MONOMER |
PathwayCommonsi | O14957 |
Reactomei | R-HSA-611105, Respiratory electron transport |
SIGNORi | O14957 |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome b-c1 complex subunit 10Alternative name(s): Complex III subunit 10 Complex III subunit XI Ubiquinol-cytochrome c reductase complex 6.4 kDa protein |
Gene namesi | Name:UQCR11 Synonyms:UQCR |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30862, UQCR11 |
MIMi | 609711, gene |
neXtProti | NX_O14957 |
VEuPathDBi | HostDB:ENSG00000127540.11 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane By similarity; Single-pass membrane protein By similarity
Mitochondrion
- mitochondrial inner membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
- respirasome Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 12 | Mitochondrial matrix1 PublicationAdd BLAST | 12 | |
Transmembranei | 13 – 35 | Helical1 PublicationAdd BLAST | 23 | |
Topological domaini | 36 – 56 | Mitochondrial intermembrane1 PublicationAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePathology & Biotechi
Organism-specific databases
DisGeNETi | 10975 |
OpenTargetsi | ENSG00000127540 |
PharmGKBi | PA165394505 |
Miscellaneous databases
Pharosi | O14957, Tdark |
Chemistry databases
DrugBanki | DB07763, (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE DB07778, (S)-famoxadone DB08453, 2-Nonyl-4-quinolinol 1-oxide DB04799, 6-Hydroxy-5-undecyl-4,7-benzothiazoledione DB07401, Azoxystrobin DB08330, METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE DB08690, Ubiquinone Q2 |
Genetic variation databases
BioMutai | UQCR11 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000193560 | 1 – 56 | Cytochrome b-c1 complex subunit 10Add BLAST | 56 |
Proteomic databases
EPDi | O14957 |
jPOSTi | O14957 |
MassIVEi | O14957 |
MaxQBi | O14957 |
PaxDbi | O14957 |
PeptideAtlasi | O14957 |
PRIDEi | O14957 |
ProteomicsDBi | 48334 |
TopDownProteomicsi | O14957 |
Expressioni
Gene expression databases
Bgeei | ENSG00000127540, Expressed in endothelial cell and 255 other tissues |
Genevisiblei | O14957, HS |
Organism-specific databases
HPAi | ENSG00000127540, Tissue enhanced (blood, skeletal muscle) |
Interactioni
Subunit structurei
Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1 (By similarity). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI1III2IV1 and megacomplex MCI2III2IV2) (PubMed:28844695).
By similarity1 PublicationProtein-protein interaction databases
BioGRIDi | 116172, 5 interactors |
ComplexPortali | CPX-560, Mitochondrial respiratory chain complex III |
IntActi | O14957, 2 interactors |
STRINGi | 9606.ENSP00000467262 |
Miscellaneous databases
RNActi | O14957, protein |
Structurei
Secondary structure
3D structure databases
SMRi | O14957 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S9FZ, Eukaryota |
GeneTreei | ENSGT00390000018299 |
HOGENOMi | CLU_211742_0_0_1 |
InParanoidi | O14957 |
OMAi | RELAKNW |
OrthoDBi | 1621371at2759 |
PhylomeDBi | O14957 |
TreeFami | TF105034 |
Family and domain databases
InterProi | View protein in InterPro IPR029027, Single_a-helix_sf IPR015089, UQCR |
PANTHERi | PTHR15420, PTHR15420, 1 hit |
Pfami | View protein in Pfam PF08997, UCR_6-4kD, 1 hit |
SUPFAMi | SSF81518, SSF81518, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MVTRFLGPRY RELVKNWVPT AYTWGAVGAV GLVWATDWRL ILDWVPYING
KFKKDN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D55636 mRNA Translation: BAA21748.1 AK312053 mRNA Translation: BAG34989.1 AC005321 Genomic DNA Translation: AAC27374.1 AC005943 Genomic DNA Translation: AAC72105.1 CH471139 Genomic DNA Translation: EAW69474.1 CH471139 Genomic DNA Translation: EAW69475.1 CH471139 Genomic DNA Translation: EAW69476.1 BC000462 mRNA Translation: AAH00462.1 BC003594 mRNA Translation: AAH03594.1 |
CCDSi | CCDS12073.1 |
RefSeqi | NP_006821.1, NM_006830.3 |
Genome annotation databases
Ensembli | ENST00000585671; ENSP00000466420; ENSG00000127540 ENST00000589880; ENSP00000467555; ENSG00000127540 ENST00000591899; ENSP00000467262; ENSG00000127540 |
GeneIDi | 10975 |
KEGGi | hsa:10975 |
UCSCi | uc002ltm.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D55636 mRNA Translation: BAA21748.1 AK312053 mRNA Translation: BAG34989.1 AC005321 Genomic DNA Translation: AAC27374.1 AC005943 Genomic DNA Translation: AAC72105.1 CH471139 Genomic DNA Translation: EAW69474.1 CH471139 Genomic DNA Translation: EAW69475.1 CH471139 Genomic DNA Translation: EAW69476.1 BC000462 mRNA Translation: AAH00462.1 BC003594 mRNA Translation: AAH03594.1 |
CCDSi | CCDS12073.1 |
RefSeqi | NP_006821.1, NM_006830.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5XTE | electron microscopy | 3.40 | G/T | 2-52 | [»] | |
5XTH | electron microscopy | 3.90 | AG/AT | 2-52 | [»] | |
5XTI | electron microscopy | 17.40 | AG/AT | 2-52 | [»] | |
SMRi | O14957 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116172, 5 interactors |
ComplexPortali | CPX-560, Mitochondrial respiratory chain complex III |
IntActi | O14957, 2 interactors |
STRINGi | 9606.ENSP00000467262 |
Chemistry databases
DrugBanki | DB07763, (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE DB07778, (S)-famoxadone DB08453, 2-Nonyl-4-quinolinol 1-oxide DB04799, 6-Hydroxy-5-undecyl-4,7-benzothiazoledione DB07401, Azoxystrobin DB08330, METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE DB08690, Ubiquinone Q2 |
Genetic variation databases
BioMutai | UQCR11 |
Proteomic databases
EPDi | O14957 |
jPOSTi | O14957 |
MassIVEi | O14957 |
MaxQBi | O14957 |
PaxDbi | O14957 |
PeptideAtlasi | O14957 |
PRIDEi | O14957 |
ProteomicsDBi | 48334 |
TopDownProteomicsi | O14957 |
Protocols and materials databases
Antibodypediai | 42255, 69 antibodies |
DNASUi | 10975 |
Genome annotation databases
Ensembli | ENST00000585671; ENSP00000466420; ENSG00000127540 ENST00000589880; ENSP00000467555; ENSG00000127540 ENST00000591899; ENSP00000467262; ENSG00000127540 |
GeneIDi | 10975 |
KEGGi | hsa:10975 |
UCSCi | uc002ltm.4, human |
Organism-specific databases
CTDi | 10975 |
DisGeNETi | 10975 |
GeneCardsi | UQCR11 |
HGNCi | HGNC:30862, UQCR11 |
HPAi | ENSG00000127540, Tissue enhanced (blood, skeletal muscle) |
MIMi | 609711, gene |
neXtProti | NX_O14957 |
OpenTargetsi | ENSG00000127540 |
PharmGKBi | PA165394505 |
VEuPathDBi | HostDB:ENSG00000127540.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S9FZ, Eukaryota |
GeneTreei | ENSGT00390000018299 |
HOGENOMi | CLU_211742_0_0_1 |
InParanoidi | O14957 |
OMAi | RELAKNW |
OrthoDBi | 1621371at2759 |
PhylomeDBi | O14957 |
TreeFami | TF105034 |
Enzyme and pathway databases
BioCyci | MetaCyc:HS05111-MONOMER |
PathwayCommonsi | O14957 |
Reactomei | R-HSA-611105, Respiratory electron transport |
SIGNORi | O14957 |
Miscellaneous databases
BioGRID-ORCSi | 10975, 68 hits in 990 CRISPR screens |
ChiTaRSi | UQCR11, human |
GenomeRNAii | 10975 |
Pharosi | O14957, Tdark |
PROi | PR:O14957 |
RNActi | O14957, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000127540, Expressed in endothelial cell and 255 other tissues |
Genevisiblei | O14957, HS |
Family and domain databases
InterProi | View protein in InterPro IPR029027, Single_a-helix_sf IPR015089, UQCR |
PANTHERi | PTHR15420, PTHR15420, 1 hit |
Pfami | View protein in Pfam PF08997, UCR_6-4kD, 1 hit |
SUPFAMi | SSF81518, SSF81518, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | QCR10_HUMAN | |
Accessioni | O14957Primary (citable) accession number: O14957 Secondary accession number(s): B2R542 Q9UPK4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | January 1, 1998 | |
Last modified: | April 7, 2021 | |
This is version 167 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families