Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - O14957 (QCR10_HUMAN)

Entry version 168 (02 Jun 2021)
Sequence version 1 (01 Jan 1998)
Previous versions | rss
Add a publicationFeedback
Protein

Cytochrome b-c1 complex subunit 10

Gene

UQCR11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. QCR10 has a role in CIII assembly and RIP1 stability.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS05111-MONOMER

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O14957

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-611105, Respiratory electron transport

SIGNOR Signaling Network Open Resource

More...SIGNORi		O14957

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 10
Alternative name(s):
Complex III subunit 10
Complex III subunit XI
Ubiquinol-cytochrome c reductase complex 6.4 kDa protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UQCR11
Synonyms:UQCR
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:30862, UQCR11

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609711, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O14957

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000127540.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 12Mitochondrial matrix1 PublicationAdd BLAST12
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei13 – 35Helical1 PublicationAdd BLAST23
Topological domaini36 – 56Mitochondrial intermembrane1 PublicationAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		10975

Open Targets

More...OpenTargetsi		ENSG00000127540

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA165394505

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O14957, Tdark

Chemistry databases

Drug and drug target database

More...DrugBanki		DB07763, (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE
DB07778, (S)-famoxadone
DB08453, 2-Nonyl-4-quinolinol 1-oxide
DB04799, 6-Hydroxy-5-undecyl-4,7-benzothiazoledione
DB07401, Azoxystrobin
DB08330, METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE
DB08690, Ubiquinone Q2

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		UQCR11

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001935601 – 56Cytochrome b-c1 complex subunit 10Add BLAST56

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O14957

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O14957

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O14957

MaxQB - The MaxQuant DataBase

More...MaxQBi		O14957

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O14957

PeptideAtlas

More...PeptideAtlasi		O14957

PRoteomics IDEntifications database

More...PRIDEi		O14957

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		48334

Consortium for Top Down Proteomics

More...TopDownProteomicsi		O14957

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000127540, Expressed in endothelial cell and 256 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O14957, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000127540, Tissue enhanced (blood, skeletal muscle)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1 (By similarity). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI1III2IV1 and megacomplex MCI2III2IV2) (PubMed:28844695).

By similarity1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116172, 5 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-560, Mitochondrial respiratory chain complex III

Protein interaction database and analysis system

More...IntActi		O14957, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000467262

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O14957, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

156
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O14957

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UQCR11/QCR10 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S9FZ, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000018299

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_211742_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O14957

Identification of Orthologs from Complete Genome Data

More...OMAi		RELAKNW

Database of Orthologous Groups

More...OrthoDBi		1621371at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O14957

TreeFam database of animal gene trees

More...TreeFami		TF105034

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029027, Single_a-helix_sf
IPR015089, UQCR

The PANTHER Classification System

More...PANTHERi		PTHR15420, PTHR15420, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08997, UCR_6-4kD, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF81518, SSF81518, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O14957-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVTRFLGPRY RELVKNWVPT AYTWGAVGAV GLVWATDWRL ILDWVPYING 

KFKKDN
Length:56
Mass (Da):6,570
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0AE1CB90A205112C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D55636 mRNA Translation: BAA21748.1
AK312053 mRNA Translation: BAG34989.1
AC005321 Genomic DNA Translation: AAC27374.1
AC005943 Genomic DNA Translation: AAC72105.1
CH471139 Genomic DNA Translation: EAW69474.1
CH471139 Genomic DNA Translation: EAW69475.1
CH471139 Genomic DNA Translation: EAW69476.1
BC000462 mRNA Translation: AAH00462.1
BC003594 mRNA Translation: AAH03594.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12073.1

NCBI Reference Sequences

More...RefSeqi		NP_006821.1, NM_006830.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000585671; ENSP00000466420; ENSG00000127540
ENST00000589880; ENSP00000467555; ENSG00000127540
ENST00000591899; ENSP00000467262; ENSG00000127540

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10975

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10975

UCSC genome browser

More...UCSCi		uc002ltm.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D55636 mRNA Translation: BAA21748.1
AK312053 mRNA Translation: BAG34989.1
AC005321 Genomic DNA Translation: AAC27374.1
AC005943 Genomic DNA Translation: AAC72105.1
CH471139 Genomic DNA Translation: EAW69474.1
CH471139 Genomic DNA Translation: EAW69475.1
CH471139 Genomic DNA Translation: EAW69476.1
BC000462 mRNA Translation: AAH00462.1
BC003594 mRNA Translation: AAH03594.1
CCDSiCCDS12073.1
RefSeqiNP_006821.1, NM_006830.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XTEelectron microscopy3.40G/T2-52[»]
5XTHelectron microscopy3.90AG/AT2-52[»]
5XTIelectron microscopy17.40AG/AT2-52[»]
SMRiO14957
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116172, 5 interactors
ComplexPortaliCPX-560, Mitochondrial respiratory chain complex III
IntActiO14957, 2 interactors
STRINGi9606.ENSP00000467262

Chemistry databases

DrugBankiDB07763, (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE
DB07778, (S)-famoxadone
DB08453, 2-Nonyl-4-quinolinol 1-oxide
DB04799, 6-Hydroxy-5-undecyl-4,7-benzothiazoledione
DB07401, Azoxystrobin
DB08330, METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE
DB08690, Ubiquinone Q2

Genetic variation databases

BioMutaiUQCR11

Proteomic databases

EPDiO14957
jPOSTiO14957
MassIVEiO14957
MaxQBiO14957
PaxDbiO14957
PeptideAtlasiO14957
PRIDEiO14957
ProteomicsDBi48334
TopDownProteomicsiO14957

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		42255, 69 antibodies

The DNASU plasmid repository

More...DNASUi		10975

Genome annotation databases

EnsembliENST00000585671; ENSP00000466420; ENSG00000127540
ENST00000589880; ENSP00000467555; ENSG00000127540
ENST00000591899; ENSP00000467262; ENSG00000127540
GeneIDi10975
KEGGihsa:10975
UCSCiuc002ltm.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10975
DisGeNETi10975

GeneCards: human genes, protein and diseases

More...GeneCardsi		UQCR11
HGNCiHGNC:30862, UQCR11
HPAiENSG00000127540, Tissue enhanced (blood, skeletal muscle)
MIMi609711, gene
neXtProtiNX_O14957
OpenTargetsiENSG00000127540
PharmGKBiPA165394505
VEuPathDBiHostDB:ENSG00000127540.11

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S9FZ, Eukaryota
GeneTreeiENSGT00390000018299
HOGENOMiCLU_211742_0_0_1
InParanoidiO14957
OMAiRELAKNW
OrthoDBi1621371at2759
PhylomeDBiO14957
TreeFamiTF105034

Enzyme and pathway databases

BioCyciMetaCyc:HS05111-MONOMER
PathwayCommonsiO14957
ReactomeiR-HSA-611105, Respiratory electron transport
SIGNORiO14957

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10975, 68 hits in 990 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		UQCR11, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10975
PharosiO14957, Tdark

Protein Ontology

More...PROi		PR:O14957
RNActiO14957, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000127540, Expressed in endothelial cell and 256 other tissues
GenevisibleiO14957, HS

Family and domain databases

InterProiView protein in InterPro
IPR029027, Single_a-helix_sf
IPR015089, UQCR
PANTHERiPTHR15420, PTHR15420, 1 hit
PfamiView protein in Pfam
PF08997, UCR_6-4kD, 1 hit
SUPFAMiSSF81518, SSF81518, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQCR10_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O14957
Secondary accession number(s): B2R542
, D6W5Z4, Q9UEA3, Q9UPK4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: June 2, 2021
This is version 168 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again