UQCR11

Functionⁱ

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain.

This protein may be closely linked to the iron-sulfur protein in the complex and function as an iron-sulfur protein binding factor.

GO - Molecular functionⁱ

electron transfer activity
Source: UniProtKB
Traceable author statementⁱ
- 9161705
ubiquinol-cytochrome-c reductase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

generation of precursor metabolites and energy
Source: ProtInc
Traceable author statementⁱ
- 9161705

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Electron transport, Respiratory chain, Transport

Biological process

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-611105 Respiratory electron transport

Reactomeⁱ

R-HSA-611105 Respiratory electron transport

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cytochrome b-c1 complex subunit 10 Alternative name(s): Complex III subunit 10 Complex III subunit XI Ubiquinol-cytochrome c reductase complex 6.4 kDa protein
Gene namesⁱ	Name:UQCR11 Synonyms:UQCR
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000127540.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30862 UQCR11
MIMⁱ	609711 gene
neXtProtⁱ	NX_O14957

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	16 – 36	HelicalSequence analysisAdd BLAST		21

Keywords - Cellular componentⁱ

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10975
Open Targets More...OpenTargetsⁱ	ENSG00000127540
PharmGKBⁱ	PA165394505

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB08453 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE DB07778 FAMOXADONE DB07401 METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE DB08330 METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE DB08690 UBIQUINONE-2

DrugBankⁱ

DB08453 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE
DB07778 FAMOXADONE
DB07401 METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE
DB08330 METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE
DB08690 UBIQUINONE-2

Polymorphism and mutation databases

BioMutaⁱ	UQCR11

BioMutaⁱ

UQCR11

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000193560	1 – 56	Cytochrome b-c1 complex subunit 10Add BLAST		56

Proteomic databases

EPDⁱ	O14957
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O14957
PaxDbⁱ	O14957
PeptideAtlas More...PeptideAtlasⁱ	O14957
PRIDEⁱ	O14957
ProteomicsDBⁱ	48334
TopDownProteomicsⁱ	O14957

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000127540 Expressed in 243 organ(s), highest expression level in endothelial cell
CleanExⁱ	HS_UQCR
Genevisibleⁱ	O14957 HS

Interactionⁱ

Subunit structureⁱ

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

Protein-protein interaction databases

BioGridⁱ	116172, 4 interactors
ComplexPortalⁱ	CPX-560 Mitochondrial respiratory chain complex III
IntActⁱ	O14957, 1 interactor
STRINGⁱ	9606.ENSP00000466420

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	3 – 5	Combined sources	3
Helixⁱ	8 – 35	Combined sources	28
Helixⁱ	39 – 42	Combined sources	4
Beta strandⁱ	45 – 47	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	O14957
SMRⁱ	O14957
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the UQCR11/QCR10 family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410J5Z0 Eukaryota ENOG410XVMI LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000018299
HOGENOMⁱ	HOG000030914
HOVERGENⁱ	HBG105467
InParanoidⁱ	O14957
KEGG Orthology (KO) More...KOⁱ	K00420
OMAⁱ	RELAKNW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G1ATB
PhylomeDBⁱ	O14957
TreeFamⁱ	TF105034

Family and domain databases

InterProⁱ	View protein in InterPro IPR029027 Single_a-helix_sf IPR015089 UQCR
PANTHERⁱ	PTHR15420 PTHR15420, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08997 UCR_6-4kD, 1 hit
SUPFAMⁱ	SSF81518 SSF81518, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

O14957-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVTRFLGPRY RELVKNWVPT AYTWGAVGAV GLVWATDWRL ILDWVPYING 

KFKKDN

Length:56

Mass (Da):6,570

Last modified:January 1, 1998 - v1

Checksum:ⁱ0AE1CB90A205112C

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D55636 mRNA Translation: BAA21748.1 AK312053 mRNA Translation: BAG34989.1 AC005321 Genomic DNA Translation: AAC27374.1 AC005943 Genomic DNA Translation: AAC72105.1 CH471139 Genomic DNA Translation: EAW69474.1 CH471139 Genomic DNA Translation: EAW69475.1 CH471139 Genomic DNA Translation: EAW69476.1 BC000462 mRNA Translation: AAH00462.1 BC003594 mRNA Translation: AAH03594.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12073.1
NCBI Reference Sequences More...RefSeqⁱ	NP_006821.1, NM_006830.3
UniGeneⁱ	Hs.8372

Genome annotation databases

Ensemblⁱ	ENST00000585671; ENSP00000466420; ENSG00000127540 ENST00000589880; ENSP00000467555; ENSG00000127540 ENST00000591899; ENSP00000467262; ENSG00000127540
GeneIDⁱ	10975
KEGGⁱ	hsa:10975
UCSC genome browser More...UCSCⁱ	uc002ltm.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O14957	UQCR11 isoform 1		PANTR		56	UniRef100_O14957
UPI000BA4E656		HUMAN		51

Protein	Similar proteins		Species	Score	Length	Source
O14957	UQCR11 isoform 1		PANTR		56	UniRef90_O14957
Cytochrome b-c1 complex subunit 10		MACMU		56
Ubiquinol-cytochrome c reductase complex 6.4 kDa protein		MACFA		56
Cytochrome b-c1 complex subunit 10		PONAB		56
Uncharacterized protein		COLAP		56
+9

Protein	Similar proteins		Species	Score	Length	Source
O14957	Cytochrome b-c1 complex subunit 10		MOUSE		56	UniRef50_O14957
Cytochrome b-c1 complex subunit 10	)	BOVIN		56
UQCR11 isoform 1		PANTR		56
Uncharacterized protein		PAPAN		56
Cytochrome b-c1 complex subunit 10		PONAB		56
+148

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D55636 mRNA Translation: BAA21748.1 AK312053 mRNA Translation: BAG34989.1 AC005321 Genomic DNA Translation: AAC27374.1 AC005943 Genomic DNA Translation: AAC72105.1 CH471139 Genomic DNA Translation: EAW69474.1 CH471139 Genomic DNA Translation: EAW69475.1 CH471139 Genomic DNA Translation: EAW69476.1 BC000462 mRNA Translation: AAH00462.1 BC003594 mRNA Translation: AAH03594.1
CCDSⁱ	CCDS12073.1
RefSeqⁱ	NP_006821.1, NM_006830.3
UniGeneⁱ	Hs.8372

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5XTE	electron microscopy	3.40	G/T	2-52	[»]
	5XTH	electron microscopy	3.90	AG/AT	2-52	[»]
	5XTI	electron microscopy	17.40	AG/AT	2-52	[»]
ProteinModelPortalⁱ	O14957
SMRⁱ	O14957
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116172, 4 interactors
ComplexPortalⁱ	CPX-560 Mitochondrial respiratory chain complex III
IntActⁱ	O14957, 1 interactor
STRINGⁱ	9606.ENSP00000466420

Chemistry databases

DrugBankⁱ	DB08453 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE DB07778 FAMOXADONE DB07401 METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE DB08330 METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE DB08690 UBIQUINONE-2

DrugBankⁱ

DB08453 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE
DB07778 FAMOXADONE
DB07401 METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE
DB08330 METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE
DB08690 UBIQUINONE-2

Polymorphism and mutation databases

BioMutaⁱ	UQCR11

BioMutaⁱ

UQCR11

Proteomic databases

EPDⁱ	O14957
MaxQBⁱ	O14957
PaxDbⁱ	O14957
PeptideAtlasⁱ	O14957
PRIDEⁱ	O14957
ProteomicsDBⁱ	48334
TopDownProteomicsⁱ	O14957

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	10975
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000585671; ENSP00000466420; ENSG00000127540 ENST00000589880; ENSP00000467555; ENSG00000127540 ENST00000591899; ENSP00000467262; ENSG00000127540
GeneIDⁱ	10975
KEGGⁱ	hsa:10975
UCSCⁱ	uc002ltm.4 human

Organism-specific databases

CTDⁱ	10975
DisGeNETⁱ	10975
EuPathDBⁱ	HostDB:ENSG00000127540.11
GeneCardsⁱ	UQCR11
HGNCⁱ	HGNC:30862 UQCR11
MIMⁱ	609711 gene
neXtProtⁱ	NX_O14957
OpenTargetsⁱ	ENSG00000127540
PharmGKBⁱ	PA165394505
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J5Z0 Eukaryota ENOG410XVMI LUCA
GeneTreeⁱ	ENSGT00390000018299
HOGENOMⁱ	HOG000030914
HOVERGENⁱ	HBG105467
InParanoidⁱ	O14957
KOⁱ	K00420
OMAⁱ	RELAKNW
OrthoDBⁱ	EOG091G1ATB
PhylomeDBⁱ	O14957
TreeFamⁱ	TF105034

Enzyme and pathway databases

Reactomeⁱ	R-HSA-611105 Respiratory electron transport

Reactomeⁱ

R-HSA-611105 Respiratory electron transport

Miscellaneous databases

ChiTaRSⁱ	UQCR11 human
GenomeRNAiⁱ	10975
Protein Ontology More...PROⁱ	PR:O14957
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000127540 Expressed in 243 organ(s), highest expression level in endothelial cell
CleanExⁱ	HS_UQCR
Genevisibleⁱ	O14957 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR029027 Single_a-helix_sf IPR015089 UQCR
PANTHERⁱ	PTHR15420 PTHR15420, 1 hit
Pfamⁱ	View protein in Pfam PF08997 UCR_6-4kD, 1 hit
SUPFAMⁱ	SSF81518 SSF81518, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	QCR10_HUMAN
Accessionⁱ	O14957Primary (citable) accession number: O14957 Secondary accession number(s): B2R542 , D6W5Z4, Q9UEA3, Q9UPK4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
	Last sequence update:	January 1, 1998
	Last modified:	November 7, 2018
	This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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Supporting data

UniProtKB - O14957 (QCR10_HUMAN)

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Cytochrome b-c1 complex subunit 10

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ