Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcription factor EC

Gene

TFEC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity). Collaborates with MITF in target gene activation (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity). Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity). Binds DNA in a homo- or heterodimeric form.By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O14948

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription factor EC
Short name:
TFE-C
Alternative name(s):
Class E basic helix-loop-helix protein 34
Short name:
bHLHe34
Transcription factor EC-like
Short name:
hTFEC-L
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TFEC
Synonyms:BHLHE34, TCFEC, TFECL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000105967.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11754 TFEC

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604732 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O14948

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
22797

Open Targets

More...
OpenTargetsi
ENSG00000105967

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36469

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TFEC

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003135641 – 347Transcription factor ECAdd BLAST347

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O14948

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O14948

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O14948

PeptideAtlas

More...
PeptideAtlasi
O14948

PRoteomics IDEntifications database

More...
PRIDEi
O14948

ProteomicsDB human proteome resource

More...
ProteomicsDBi
48328
48329 [O14948-2]
48330 [O14948-3]
48331 [O14948-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O14948

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O14948

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed moderately in spleen, kidney, bone marrow, small intestine and leukocytes. Expressed weakly in testis, trachea and colon.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000105967 Expressed in 138 organ(s), highest expression level in intestine

CleanEx database of gene expression profiles

More...
CleanExi
HS_TFEC

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O14948 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O14948 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB032260
HPA063577

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Forms heterodimers with TFE3. Forms heterodimers with MITF (By similarity). Interacts with MITF (By similarity).By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116478, 9 interactors

Protein interaction database and analysis system

More...
IntActi
O14948, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000265440

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O14948

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O14948

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini139 – 192bHLHPROSITE-ProRule annotationAdd BLAST54

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 119Necessary for transcriptional transactivationAdd BLAST119
Regioni271 – 347Necessary for transcriptional transactivationAdd BLAST77

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MiT/TFE family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1318 Eukaryota
ENOG4110SME LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159404

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231368

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG006768

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O14948

KEGG Orthology (KO)

More...
KOi
K15591

Identification of Orthologs from Complete Genome Data

More...
OMAi
CDQAMAF

Database of Orthologous Groups

More...
OrthoDBi
1211990at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O14948

TreeFam database of animal gene trees

More...
TreeFami
TF317174

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00083 HLH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.280.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011598 bHLH_dom
IPR024097 bHLH_ZIP_TF
IPR036638 HLH_DNA-bd_sf
IPR021802 MiT/TFE_C
IPR024101 TFEC

The PANTHER Classification System

More...
PANTHERi
PTHR12565 PTHR12565, 1 hit
PTHR12565:SF106 PTHR12565:SF106, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11851 DUF3371, 1 hit
PF00010 HLH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00353 HLH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47459 SSF47459, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50888 BHLH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O14948-1) [UniParc]FASTAAdd to basket
Also known as: TFEC-l, TFECL

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTLDHQIINP TLKWSQPAVP SGGPLVQHAH TTLDSDAGLT ENPLTKLLAI
60 70 80 90 100
GKEDDNAQWH MEDVIEDIIG MESSFKEEGA DSPLLMQRTL SGSILDVYSG
110 120 130 140 150
EQGISPINMG LTSASCPSSL PMKREITETD TRALAKERQK KDNHNLIERR
160 170 180 190 200
RRYNINYRIK ELGTLIPKSN DPDMRWNKGT ILKASVEYIK WLQKEQQRAR
210 220 230 240 250
ELEHRQKKLE QANRRLLLRI QELEIQARTH GLPTLASLGT VDLGAHVTKQ
260 270 280 290 300
QSHPEQNSVD YCQQLTVSQG PSPELCDQAI AFSDPLSYFT DLSFSAALKE
310 320 330 340
EQRLDGMLLD DTISPFGTDP LLSATSPAVS KESSRRSSFS SDDGDEL
Length:347
Mass (Da):38,788
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA29B4C4A1C88A985
GO
Isoform 2 (identifier: O14948-2) [UniParc]FASTAAdd to basket
Also known as: TFEC-s

The sequence of this isoform differs from the canonical sequence as follows:
     61-89: Missing.

Show »
Length:318
Mass (Da):35,534
Checksum:i116B359EFB5CA1C2
GO
Isoform 3 (identifier: O14948-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     61-89: Missing.
     222-226: ELEIQ → VFIRM
     227-347: Missing.

Note: No experimental confirmation available.
Show »
Length:197
Mass (Da):22,653
Checksum:iE1EAE9B8D51EDCAC
GO
Isoform 4 (identifier: O14948-4) [UniParc]FASTAAdd to basket
Also known as: TFEC-C

The sequence of this isoform differs from the canonical sequence as follows:
     1-67: Missing.
     68-89: IIGMESSFKEEGADSPLLMQRT → MMKEKEKTIAIVKVIDTSKLKL

Show »
Length:280
Mass (Da):31,558
Checksum:i44F6744A278E5255
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7Z757B7Z757_HUMAN
Transcription factor EC
TFEC
316Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0376616Q → H. Corresponds to variant dbSNP:rs35695387Ensembl.1
Natural variantiVAR_037662100G → S. Corresponds to variant dbSNP:rs35170691Ensembl.1
Natural variantiVAR_037663146L → V in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0300221 – 67Missing in isoform 4. 1 PublicationAdd BLAST67
Alternative sequenceiVSP_03002361 – 89Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST29
Alternative sequenceiVSP_03002468 – 89IIGME…LMQRT → MMKEKEKTIAIVKVIDTSKL KL in isoform 4. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_030025222 – 226ELEIQ → VFIRM in isoform 3. 1 Publication5
Alternative sequenceiVSP_030026227 – 347Missing in isoform 3. 1 PublicationAdd BLAST121

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D43945 mRNA Translation: BAA21908.1
AK313546 mRNA Translation: BAG36322.1
CR933605 mRNA Translation: CAI45926.1
CH236947 Genomic DNA Translation: EAL24366.1
CH471070 Genomic DNA Translation: EAW83491.1
CH471070 Genomic DNA Translation: EAW83492.1
BC029891 mRNA Translation: AAH29891.1
AJ608795 mRNA Translation: CAE77680.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34738.1 [O14948-2]
CCDS5762.1 [O14948-1]
CCDS59076.1 [O14948-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001018068.1, NM_001018058.2 [O14948-2]
NP_001231512.1, NM_001244583.1 [O14948-4]
NP_036384.1, NM_012252.3 [O14948-1]
XP_016867364.1, XM_017011875.1 [O14948-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.125962

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000265440; ENSP00000265440; ENSG00000105967 [O14948-1]
ENST00000320239; ENSP00000318676; ENSG00000105967 [O14948-2]
ENST00000393485; ENSP00000377125; ENSG00000105967 [O14948-3]
ENST00000457268; ENSP00000387650; ENSG00000105967 [O14948-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
22797

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:22797

UCSC genome browser

More...
UCSCi
uc003vhj.3 human [O14948-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D43945 mRNA Translation: BAA21908.1
AK313546 mRNA Translation: BAG36322.1
CR933605 mRNA Translation: CAI45926.1
CH236947 Genomic DNA Translation: EAL24366.1
CH471070 Genomic DNA Translation: EAW83491.1
CH471070 Genomic DNA Translation: EAW83492.1
BC029891 mRNA Translation: AAH29891.1
AJ608795 mRNA Translation: CAE77680.1
CCDSiCCDS34738.1 [O14948-2]
CCDS5762.1 [O14948-1]
CCDS59076.1 [O14948-4]
RefSeqiNP_001018068.1, NM_001018058.2 [O14948-2]
NP_001231512.1, NM_001244583.1 [O14948-4]
NP_036384.1, NM_012252.3 [O14948-1]
XP_016867364.1, XM_017011875.1 [O14948-1]
UniGeneiHs.125962

3D structure databases

ProteinModelPortaliO14948
SMRiO14948
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116478, 9 interactors
IntActiO14948, 7 interactors
STRINGi9606.ENSP00000265440

PTM databases

iPTMnetiO14948
PhosphoSitePlusiO14948

Polymorphism and mutation databases

BioMutaiTFEC

Proteomic databases

jPOSTiO14948
MaxQBiO14948
PaxDbiO14948
PeptideAtlasiO14948
PRIDEiO14948
ProteomicsDBi48328
48329 [O14948-2]
48330 [O14948-3]
48331 [O14948-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
22797
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265440; ENSP00000265440; ENSG00000105967 [O14948-1]
ENST00000320239; ENSP00000318676; ENSG00000105967 [O14948-2]
ENST00000393485; ENSP00000377125; ENSG00000105967 [O14948-3]
ENST00000457268; ENSP00000387650; ENSG00000105967 [O14948-4]
GeneIDi22797
KEGGihsa:22797
UCSCiuc003vhj.3 human [O14948-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22797
DisGeNETi22797
EuPathDBiHostDB:ENSG00000105967.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TFEC
HGNCiHGNC:11754 TFEC
HPAiCAB032260
HPA063577
MIMi604732 gene
neXtProtiNX_O14948
OpenTargetsiENSG00000105967
PharmGKBiPA36469

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1318 Eukaryota
ENOG4110SME LUCA
GeneTreeiENSGT00940000159404
HOGENOMiHOG000231368
HOVERGENiHBG006768
InParanoidiO14948
KOiK15591
OMAiCDQAMAF
OrthoDBi1211990at2759
PhylomeDBiO14948
TreeFamiTF317174

Enzyme and pathway databases

SIGNORiO14948

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TFEC

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
22797

Protein Ontology

More...
PROi
PR:O14948

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000105967 Expressed in 138 organ(s), highest expression level in intestine
CleanExiHS_TFEC
ExpressionAtlasiO14948 baseline and differential
GenevisibleiO14948 HS

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR024097 bHLH_ZIP_TF
IPR036638 HLH_DNA-bd_sf
IPR021802 MiT/TFE_C
IPR024101 TFEC
PANTHERiPTHR12565 PTHR12565, 1 hit
PTHR12565:SF106 PTHR12565:SF106, 1 hit
PfamiView protein in Pfam
PF11851 DUF3371, 1 hit
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTFEC_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O14948
Secondary accession number(s): B2R8X5
, Q5H9U8, Q709A4, Q8N6J9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 1, 1998
Last modified: January 16, 2019
This is version 149 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again