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UniProtKB - O14948 (TFEC_HUMAN)

Entry version 160 (07 Oct 2020)
Sequence version 1 (01 Jan 1998)
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Protein

Transcription factor EC

Gene

TFEC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity). Collaborates with MITF in target gene activation (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity). Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity). Binds DNA in a homo- or heterodimeric form.By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O14948

SIGNOR Signaling Network Open Resource

More...SIGNORi		O14948

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription factor EC
Short name:
TFE-C
Alternative name(s):
Class E basic helix-loop-helix protein 34
Short name:
bHLHe34
Transcription factor EC-like
Short name:
hTFEC-L
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TFEC
Synonyms:BHLHE34, TCFEC, TFECL
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000105967.15

Human Gene Nomenclature Database

More...HGNCi		HGNC:11754, TFEC

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604732, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O14948

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		22797

Open Targets

More...OpenTargetsi		ENSG00000105967

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36469

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O14948, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TFEC

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003135641 – 347Transcription factor ECAdd BLAST347

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O14948

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O14948

MaxQB - The MaxQuant DataBase

More...MaxQBi		O14948

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O14948

PeptideAtlas

More...PeptideAtlasi		O14948

PRoteomics IDEntifications database

More...PRIDEi		O14948

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		48328 [O14948-1]
48329 [O14948-2]
48330 [O14948-3]
48331 [O14948-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O14948

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O14948

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed moderately in spleen, kidney, bone marrow, small intestine and leukocytes. Expressed weakly in testis, trachea and colon.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000105967, Expressed in intestine and 160 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O14948, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O14948, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000105967, Tissue enhanced (kidney)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Forms heterodimers with TFE3. Forms heterodimers with MITF (By similarity).

Interacts with MITF (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116478, 12 interactors

Protein interaction database and analysis system

More...IntActi		O14948, 8 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000265440

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O14948, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O14948

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini139 – 192bHLHPROSITE-ProRule annotationAdd BLAST54

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 119Necessary for transcriptional transactivationAdd BLAST119
Regioni271 – 347Necessary for transcriptional transactivationAdd BLAST77

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MiT/TFE family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1318, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159404

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_031638_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O14948

KEGG Orthology (KO)

More...KOi		K15591

Identification of Orthologs from Complete Genome Data

More...OMAi		IINMESS

Database of Orthologous Groups

More...OrthoDBi		1211990at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O14948

TreeFam database of animal gene trees

More...TreeFami		TF317174

Family and domain databases

Conserved Domains Database

More...CDDi		cd00083, HLH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		4.10.280.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011598, bHLH_dom
IPR036638, HLH_DNA-bd_sf
IPR021802, MiT/TFE_C
IPR024101, TFEC

The PANTHER Classification System

More...PANTHERi		PTHR45776:SF1, PTHR45776:SF1, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF11851, DUF3371, 1 hit
PF00010, HLH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00353, HLH, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47459, SSF47459, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50888, BHLH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O14948-1) [UniParc]FASTAAdd to basket
Also known as: TFEC-l, TFECL

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTLDHQIINP TLKWSQPAVP SGGPLVQHAH TTLDSDAGLT ENPLTKLLAI 
        60         70         80         90        100
GKEDDNAQWH MEDVIEDIIG MESSFKEEGA DSPLLMQRTL SGSILDVYSG 
       110        120        130        140        150
EQGISPINMG LTSASCPSSL PMKREITETD TRALAKERQK KDNHNLIERR 
       160        170        180        190        200
RRYNINYRIK ELGTLIPKSN DPDMRWNKGT ILKASVEYIK WLQKEQQRAR 
       210        220        230        240        250
ELEHRQKKLE QANRRLLLRI QELEIQARTH GLPTLASLGT VDLGAHVTKQ 
       260        270        280        290        300
QSHPEQNSVD YCQQLTVSQG PSPELCDQAI AFSDPLSYFT DLSFSAALKE 
       310        320        330        340 
EQRLDGMLLD DTISPFGTDP LLSATSPAVS KESSRRSSFS SDDGDEL
Length:347
Mass (Da):38,788
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA29B4C4A1C88A985
GO
Isoform 2 (identifier: O14948-2) [UniParc]FASTAAdd to basket
Also known as: TFEC-s

The sequence of this isoform differs from the canonical sequence as follows:
     61-89: Missing.

Show »
Length:318
Mass (Da):35,534
Checksum:i116B359EFB5CA1C2
GO
Isoform 3 (identifier: O14948-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     61-89: Missing.
     222-226: ELEIQ → VFIRM
     227-347: Missing.

Show »
Length:197
Mass (Da):22,653
Checksum:iE1EAE9B8D51EDCAC
GO
Isoform 4 (identifier: O14948-4) [UniParc]FASTAAdd to basket
Also known as: TFEC-C

The sequence of this isoform differs from the canonical sequence as follows:
     1-67: Missing.
     68-89: IIGMESSFKEEGADSPLLMQRT → MMKEKEKTIAIVKVIDTSKLKL

Show »
Length:280
Mass (Da):31,558
Checksum:i44F6744A278E5255
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7Z757B7Z757_HUMAN
Transcription factor EC
TFEC
316Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0376616Q → H. Corresponds to variant dbSNP:rs35695387Ensembl.1
Natural variantiVAR_037662100G → S. Corresponds to variant dbSNP:rs35170691EnsemblClinVar.1
Natural variantiVAR_037663146L → V in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0300221 – 67Missing in isoform 4. 1 PublicationAdd BLAST67
Alternative sequenceiVSP_03002361 – 89Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST29
Alternative sequenceiVSP_03002468 – 89IIGME…LMQRT → MMKEKEKTIAIVKVIDTSKL KL in isoform 4. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_030025222 – 226ELEIQ → VFIRM in isoform 3. 1 Publication5
Alternative sequenceiVSP_030026227 – 347Missing in isoform 3. 1 PublicationAdd BLAST121

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D43945 mRNA Translation: BAA21908.1
AK313546 mRNA Translation: BAG36322.1
CR933605 mRNA Translation: CAI45926.1
CH236947 Genomic DNA Translation: EAL24366.1
CH471070 Genomic DNA Translation: EAW83491.1
CH471070 Genomic DNA Translation: EAW83492.1
BC029891 mRNA Translation: AAH29891.1
AJ608795 mRNA Translation: CAE77680.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34738.1 [O14948-2]
CCDS5762.1 [O14948-1]
CCDS59076.1 [O14948-4]

NCBI Reference Sequences

More...RefSeqi		NP_001018068.1, NM_001018058.2 [O14948-2]
NP_001231512.1, NM_001244583.1 [O14948-4]
NP_036384.1, NM_012252.3 [O14948-1]
XP_016867364.1, XM_017011875.1 [O14948-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000265440; ENSP00000265440; ENSG00000105967 [O14948-1]
ENST00000320239; ENSP00000318676; ENSG00000105967 [O14948-2]
ENST00000393485; ENSP00000377125; ENSG00000105967 [O14948-3]
ENST00000457268; ENSP00000387650; ENSG00000105967 [O14948-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		22797

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:22797

UCSC genome browser

More...UCSCi		uc003vhj.3, human [O14948-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D43945 mRNA Translation: BAA21908.1
AK313546 mRNA Translation: BAG36322.1
CR933605 mRNA Translation: CAI45926.1
CH236947 Genomic DNA Translation: EAL24366.1
CH471070 Genomic DNA Translation: EAW83491.1
CH471070 Genomic DNA Translation: EAW83492.1
BC029891 mRNA Translation: AAH29891.1
AJ608795 mRNA Translation: CAE77680.1
CCDSiCCDS34738.1 [O14948-2]
CCDS5762.1 [O14948-1]
CCDS59076.1 [O14948-4]
RefSeqiNP_001018068.1, NM_001018058.2 [O14948-2]
NP_001231512.1, NM_001244583.1 [O14948-4]
NP_036384.1, NM_012252.3 [O14948-1]
XP_016867364.1, XM_017011875.1 [O14948-1]

3D structure databases

SMRiO14948
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116478, 12 interactors
IntActiO14948, 8 interactors
STRINGi9606.ENSP00000265440

PTM databases

iPTMnetiO14948
PhosphoSitePlusiO14948

Polymorphism and mutation databases

BioMutaiTFEC

Proteomic databases

jPOSTiO14948
MassIVEiO14948
MaxQBiO14948
PaxDbiO14948
PeptideAtlasiO14948
PRIDEiO14948
ProteomicsDBi48328 [O14948-1]
48329 [O14948-2]
48330 [O14948-3]
48331 [O14948-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		31571, 218 antibodies

The DNASU plasmid repository

More...DNASUi		22797

Genome annotation databases

EnsembliENST00000265440; ENSP00000265440; ENSG00000105967 [O14948-1]
ENST00000320239; ENSP00000318676; ENSG00000105967 [O14948-2]
ENST00000393485; ENSP00000377125; ENSG00000105967 [O14948-3]
ENST00000457268; ENSP00000387650; ENSG00000105967 [O14948-4]
GeneIDi22797
KEGGihsa:22797
UCSCiuc003vhj.3, human [O14948-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		22797
DisGeNETi22797
EuPathDBiHostDB:ENSG00000105967.15

GeneCards: human genes, protein and diseases

More...GeneCardsi		TFEC
HGNCiHGNC:11754, TFEC
HPAiENSG00000105967, Tissue enhanced (kidney)
MIMi604732, gene
neXtProtiNX_O14948
OpenTargetsiENSG00000105967
PharmGKBiPA36469

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1318, Eukaryota
GeneTreeiENSGT00940000159404
HOGENOMiCLU_031638_0_0_1
InParanoidiO14948
KOiK15591
OMAiIINMESS
OrthoDBi1211990at2759
PhylomeDBiO14948
TreeFamiTF317174

Enzyme and pathway databases

PathwayCommonsiO14948
SIGNORiO14948

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		22797, 16 hits in 895 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TFEC, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TFEC

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		22797
PharosiO14948, Tbio

Protein Ontology

More...PROi		PR:O14948
RNActiO14948, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000105967, Expressed in intestine and 160 other tissues
ExpressionAtlasiO14948, baseline and differential
GenevisibleiO14948, HS

Family and domain databases

CDDicd00083, HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598, bHLH_dom
IPR036638, HLH_DNA-bd_sf
IPR021802, MiT/TFE_C
IPR024101, TFEC
PANTHERiPTHR45776:SF1, PTHR45776:SF1, 1 hit
PfamiView protein in Pfam
PF11851, DUF3371, 1 hit
PF00010, HLH, 1 hit
SMARTiView protein in SMART
SM00353, HLH, 1 hit
SUPFAMiSSF47459, SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888, BHLH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTFEC_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O14948
Secondary accession number(s): B2R8X5
, Q5H9U8, Q709A4, Q8N6J9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 1, 1998
Last modified: October 7, 2020
This is version 160 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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