TFEC

Functionⁱ

Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity). Collaborates with MITF in target gene activation (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity). Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity). Binds DNA in a homo- or heterodimeric form.By similarity2 Publications

GO - Molecular functionⁱ

DNA binding transcription factor activity
Source: ProtInc
Traceable author statementⁱ
- 9256061
protein dimerization activity Source: InterPro
RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl
transcription coactivator activity
Source: ProtInc
Traceable author statementⁱ
- 9256061
transcription corepressor activity
Source: ProtInc
Traceable author statementⁱ
- 9256061

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to heat Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding, Repressor
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

SIGNORⁱ	O14948

SIGNORⁱ

O14948

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription factor EC Short name: TFE-C Alternative name(s): Class E basic helix-loop-helix protein 34 Short name: bHLHe34 Transcription factor EC-like Short name: hTFEC-L
Gene namesⁱ	Name:TFEC Synonyms:BHLHE34, TCFEC, TFECL
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000105967.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11754 TFEC
MIMⁱ	604732 gene
neXtProtⁱ	NX_O14948

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	22797
Open Targets More...OpenTargetsⁱ	ENSG00000105967
PharmGKBⁱ	PA36469

Polymorphism and mutation databases

BioMutaⁱ	TFEC

BioMutaⁱ

TFEC

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000313564	1 – 347	Transcription factor ECAdd BLAST		347

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O14948
PaxDbⁱ	O14948
PeptideAtlas More...PeptideAtlasⁱ	O14948
PRIDEⁱ	O14948
ProteomicsDBⁱ	48328 48329 [O14948-2] 48330 [O14948-3] 48331 [O14948-4]

PTM databases

iPTMnetⁱ	O14948
PhosphoSitePlusⁱ	O14948

Expressionⁱ

Tissue specificityⁱ

Expressed moderately in spleen, kidney, bone marrow, small intestine and leukocytes. Expressed weakly in testis, trachea and colon.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000105967
CleanExⁱ	HS_TFEC
ExpressionAtlasⁱ	O14948 baseline and differential
Genevisibleⁱ	O14948 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB032260 HPA063577

HPAⁱ

CAB032260
HPA063577

Interactionⁱ

Subunit structureⁱ

Homodimer. Forms heterodimers with TFE3. Forms heterodimers with MITF (By similarity). Interacts with MITF (By similarity).By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
DEFB127	Q9H1M4	3	EBI-3916574,EBI-10305240
NAPB	Q9H115	3	EBI-3916574,EBI-3921185

Show more details

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	116478, 9 interactors
IntActⁱ	O14948, 7 interactors
STRINGⁱ	9606.ENSP00000265440

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O14948
SMRⁱ	O14948
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	139 – 192	bHLHPROSITE-ProRule annotationAdd BLAST		54

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 119	Necessary for transcriptional transactivationAdd BLAST		119
Regionⁱ	271 – 347	Necessary for transcriptional transactivationAdd BLAST		77

Sequence similaritiesⁱ

Belongs to the MiT/TFE family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1318 Eukaryota ENOG4110SME LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000004402
HOGENOMⁱ	HOG000231368
HOVERGENⁱ	HBG006768
InParanoidⁱ	O14948
KEGG Orthology (KO) More...KOⁱ	K15591
OMAⁱ	EQNSVDY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0QCO
PhylomeDBⁱ	O14948
TreeFamⁱ	TF317174

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR021802 MiT/TFE_C IPR024101 TFEC
PANTHERⁱ	PTHR12565:SF106 PTHR12565:SF106, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF11851 DUF3371, 1 hit PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit

Sequences (4)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: O14948-1) [UniParc]FASTA Add to basket

Also known as: TFEC-l, TFECL

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTLDHQIINP TLKWSQPAVP SGGPLVQHAH TTLDSDAGLT ENPLTKLLAI 
        60         70         80         90        100
GKEDDNAQWH MEDVIEDIIG MESSFKEEGA DSPLLMQRTL SGSILDVYSG 
       110        120        130        140        150
EQGISPINMG LTSASCPSSL PMKREITETD TRALAKERQK KDNHNLIERR 
       160        170        180        190        200
RRYNINYRIK ELGTLIPKSN DPDMRWNKGT ILKASVEYIK WLQKEQQRAR 
       210        220        230        240        250
ELEHRQKKLE QANRRLLLRI QELEIQARTH GLPTLASLGT VDLGAHVTKQ 
       260        270        280        290        300
QSHPEQNSVD YCQQLTVSQG PSPELCDQAI AFSDPLSYFT DLSFSAALKE 
       310        320        330        340 
EQRLDGMLLD DTISPFGTDP LLSATSPAVS KESSRRSSFS SDDGDEL

Length:347

Mass (Da):38,788

Last modified:January 1, 1998 - v1

Checksum:ⁱA29B4C4A1C88A985

GO

Isoform 2 (identifier: O14948-2) [UniParc]FASTA Add to basket

Also known as: TFEC-s

The sequence of this isoform differs from the canonical sequence as follows:
61-89: Missing.

« Hide

        10         20         30         40         50
MTLDHQIINP TLKWSQPAVP SGGPLVQHAH TTLDSDAGLT ENPLTKLLAI 
        60         70         80         90        100
GKEDDNAQWH LSGSILDVYS GEQGISPINM GLTSASCPSS LPMKREITET 
       110        120        130        140        150
DTRALAKERQ KKDNHNLIER RRRYNINYRI KELGTLIPKS NDPDMRWNKG 
       160        170        180        190        200
TILKASVEYI KWLQKEQQRA RELEHRQKKL EQANRRLLLR IQELEIQART 
       210        220        230        240        250
HGLPTLASLG TVDLGAHVTK QQSHPEQNSV DYCQQLTVSQ GPSPELCDQA 
       260        270        280        290        300
IAFSDPLSYF TDLSFSAALK EEQRLDGMLL DDTISPFGTD PLLSATSPAV 
       310 
SKESSRRSSF SSDDGDEL

Show »

Length:318

Mass (Da):35,534

Checksum:ⁱ116B359EFB5CA1C2

GO

Isoform 3 (identifier: O14948-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     61-89: Missing.
     222-226: ELEIQ → VFIRM
     227-347: Missing.

« Hide

        10         20         30         40         50
MTLDHQIINP TLKWSQPAVP SGGPLVQHAH TTLDSDAGLT ENPLTKLLAI 
        60         70         80         90        100
GKEDDNAQWH LSGSILDVYS GEQGISPINM GLTSASCPSS LPMKREITET 
       110        120        130        140        150
DTRALAKERQ KKDNHNLIER RRRYNINYRI KELGTLIPKS NDPDMRWNKG 
       160        170        180        190 
TILKASVEYI KWLQKEQQRA RELEHRQKKL EQANRRLLLR IQVFIRM

Note: No experimental confirmation available.

Show »

Length:197

Mass (Da):22,653

Checksum:ⁱE1EAE9B8D51EDCAC

GO

Isoform 4 (identifier: O14948-4) [UniParc]FASTA Add to basket

Also known as: TFEC-C

The sequence of this isoform differs from the canonical sequence as follows:
1-67: Missing.
68-89: IIGMESSFKEEGADSPLLMQRT → MMKEKEKTIAIVKVIDTSKLKL

« Hide

        10         20         30         40         50
MMKEKEKTIA IVKVIDTSKL KLLSGSILDV YSGEQGISPI NMGLTSASCP 
        60         70         80         90        100
SSLPMKREIT ETDTRALAKE RQKKDNHNLI ERRRRYNINY RIKELGTLIP 
       110        120        130        140        150
KSNDPDMRWN KGTILKASVE YIKWLQKEQQ RARELEHRQK KLEQANRRLL 
       160        170        180        190        200
LRIQELEIQA RTHGLPTLAS LGTVDLGAHV TKQQSHPEQN SVDYCQQLTV 
       210        220        230        240        250
SQGPSPELCD QAIAFSDPLS YFTDLSFSAA LKEEQRLDGM LLDDTISPFG 
       260        270        280
TDPLLSATSP AVSKESSRRS SFSSDDGDEL

Show »

Length:280

Mass (Da):31,558

Checksum:ⁱ44F6744A278E5255

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_037661	6	Q → H. Corresponds to variant dbSNP:rs35695387Ensembl.	1
Natural variantⁱVAR_037662	100	G → S. Corresponds to variant dbSNP:rs35170691Ensembl.	1
Natural variantⁱVAR_037663	146	L → V in a colorectal cancer sample; somatic mutation. 1 Publication	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_030022	1 – 67	Missing in isoform 4. 1 PublicationAdd BLAST	67
Alternative sequenceⁱVSP_030023	61 – 89	Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST	29
Alternative sequenceⁱVSP_030024	68 – 89	IIGME…LMQRT → MMKEKEKTIAIVKVIDTSKL KL in isoform 4. 1 PublicationAdd BLAST	22
Alternative sequenceⁱVSP_030025	222 – 226	ELEIQ → VFIRM in isoform 3. 1 Publication	5
Alternative sequenceⁱVSP_030026	227 – 347	Missing in isoform 3. 1 PublicationAdd BLAST	121

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D43945 mRNA Translation: BAA21908.1 AK313546 mRNA Translation: BAG36322.1 CR933605 mRNA Translation: CAI45926.1 CH236947 Genomic DNA Translation: EAL24366.1 CH471070 Genomic DNA Translation: EAW83491.1 CH471070 Genomic DNA Translation: EAW83492.1 BC029891 mRNA Translation: AAH29891.1 AJ608795 mRNA Translation: CAE77680.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34738.1 [O14948-2] CCDS5762.1 [O14948-1] CCDS59076.1 [O14948-4]
NCBI Reference Sequences More...RefSeqⁱ	NP_001018068.1, NM_001018058.2 [O14948-2] NP_001231512.1, NM_001244583.1 [O14948-4] NP_036384.1, NM_012252.3 [O14948-1] XP_016867364.1, XM_017011875.1 [O14948-1]
UniGeneⁱ	Hs.125962

Genome annotation databases

Ensemblⁱ	ENST00000265440; ENSP00000265440; ENSG00000105967 [O14948-1] ENST00000320239; ENSP00000318676; ENSG00000105967 [O14948-2] ENST00000393485; ENSP00000377125; ENSG00000105967 [O14948-3] ENST00000457268; ENSP00000387650; ENSG00000105967 [O14948-4]
GeneIDⁱ	22797
KEGGⁱ	hsa:22797
UCSC genome browser More...UCSCⁱ	uc003vhj.3 human [O14948-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
O14948	Transcription factor EC		PONPY		347
Uncharacterized protein TFEC (Fragment)		HUMAN		89
UPI000387C136		HUMAN		437
UPI0000EE40B9		HUMAN		287
O14948-2	Uncharacterized protein		PANPA		318
UPI0005D040C1		HUMAN		408
O14948-4	TFEC isoform 8		PONAB		280
Uncharacterized protein		PANPA		280

Protein	Similar proteins		Species	Score	Length
O14948	Transcription factor EC		PONPY		347
Uncharacterized protein TFEC (Fragment)		HUMAN		89
Transcription factor EC		AOTNA		439
TFEC (Fragment)		PANPA		38
TFEC (Fragment)		LAGLA		18
+45
O14948-2	Transcription factor EC		PAPAN		318
UPI00045D96CB		CHLSB		408
TFEC isoform 4		PANTR		318
Transcription factor EC		MACMU		318
Transcription factor EC		MACFA		318
+12
O14948-3	TFEC isoform 5 (Fragment)		PANTR		198
TFEC isoform 5 (Fragment)		PONAB		198
O14948-4	Transcription factor EC		CHLSB		280
Transcription factor EC		Cebus capucinus imitator		347
Transcription factor EC		SAIBB		280
Transcription factor EC		MANLE		280
UPI000C2B4EB5		Ugandan red Colobus		280
+15

Protein	Similar proteins		Species	Score	Length
O14948	Transcription factor EC		PONPY		347
Uncharacterized protein TFEC (Fragment)		HUMAN		89
Transcription factor EC		AOTNA		439
TFEC (Fragment)		PANPA		38
TFEC (Fragment)		LAGLA		18
+234
O14948-3	TFEC isoform 5 (Fragment)		PANTR		198
TFEC isoform 5 (Fragment)		PONAB		198
Transcription factor EC isoform 2 (Fragment)		DANRE		234
Transcription factor EC		TAKRU		204
O14948-4	Melanogenesis associated transcription factor		PANPA		419
UPI000A1B7ED0		Odocoileus virginianus texanus		426
Melanogenesis associated transcription factor		LOXAF		420
Microphthalmia-associated transcription factor isoform M (Fragment)		CANLF		53
UPI000657402A		HETGA		420
+143

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D43945 mRNA Translation: BAA21908.1 AK313546 mRNA Translation: BAG36322.1 CR933605 mRNA Translation: CAI45926.1 CH236947 Genomic DNA Translation: EAL24366.1 CH471070 Genomic DNA Translation: EAW83491.1 CH471070 Genomic DNA Translation: EAW83492.1 BC029891 mRNA Translation: AAH29891.1 AJ608795 mRNA Translation: CAE77680.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34738.1 [O14948-2] CCDS5762.1 [O14948-1] CCDS59076.1 [O14948-4]
NCBI Reference Sequences More...RefSeqⁱ	NP_001018068.1, NM_001018058.2 [O14948-2] NP_001231512.1, NM_001244583.1 [O14948-4] NP_036384.1, NM_012252.3 [O14948-1] XP_016867364.1, XM_017011875.1 [O14948-1]
UniGeneⁱ	Hs.125962

3D structure databases

ProteinModelPortalⁱ	O14948
SMRⁱ	O14948
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116478, 9 interactors
IntActⁱ	O14948, 7 interactors
STRINGⁱ	9606.ENSP00000265440

PTM databases

iPTMnetⁱ	O14948
PhosphoSitePlusⁱ	O14948

Polymorphism and mutation databases

BioMutaⁱ	TFEC

BioMutaⁱ

TFEC

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O14948
PaxDbⁱ	O14948
PeptideAtlas More...PeptideAtlasⁱ	O14948
PRIDEⁱ	O14948
ProteomicsDBⁱ	48328 48329 [O14948-2] 48330 [O14948-3] 48331 [O14948-4]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	22797
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000265440; ENSP00000265440; ENSG00000105967 [O14948-1] ENST00000320239; ENSP00000318676; ENSG00000105967 [O14948-2] ENST00000393485; ENSP00000377125; ENSG00000105967 [O14948-3] ENST00000457268; ENSP00000387650; ENSG00000105967 [O14948-4]
GeneIDⁱ	22797
KEGGⁱ	hsa:22797
UCSC genome browser More...UCSCⁱ	uc003vhj.3 human [O14948-1]

Organism-specific databases

CTDⁱ	22797
DisGeNET More...DisGeNETⁱ	22797
EuPathDBⁱ	HostDB:ENSG00000105967.15
GeneCardsⁱ	TFEC
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11754 TFEC
Human Protein Atlas More...HPAⁱ	CAB032260 HPA063577
MIMⁱ	604732 gene
neXtProtⁱ	NX_O14948
Open Targets More...OpenTargetsⁱ	ENSG00000105967
PharmGKBⁱ	PA36469
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1318 Eukaryota ENOG4110SME LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000004402
HOGENOMⁱ	HOG000231368
HOVERGENⁱ	HBG006768
InParanoidⁱ	O14948
KEGG Orthology (KO) More...KOⁱ	K15591
OMAⁱ	EQNSVDY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0QCO
PhylomeDBⁱ	O14948
TreeFamⁱ	TF317174

Enzyme and pathway databases

SIGNORⁱ	O14948

SIGNORⁱ

O14948

Miscellaneous databases

GeneWikiⁱ	TFEC
GenomeRNAiⁱ	22797
Protein Ontology More...PROⁱ	PR:O14948
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000105967
CleanExⁱ	HS_TFEC
ExpressionAtlasⁱ	O14948 baseline and differential
Genevisibleⁱ	O14948 HS

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR021802 MiT/TFE_C IPR024101 TFEC
PANTHERⁱ	PTHR12565:SF106 PTHR12565:SF106, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF11851 DUF3371, 1 hit PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TFEC_HUMAN
Accessionⁱ	O14948Primary (citable) accession number: O14948 Secondary accession number(s): B2R8X5 , Q5H9U8, Q709A4, Q8N6J9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
	Last sequence update:	January 1, 1998
	Last modified:	June 20, 2018
	This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

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UniProtKB - O14948 (TFEC_HUMAN)

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Transcription factor EC

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ