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Entry version 229 (29 Sep 2021)
Sequence version 3 (17 Apr 2007)
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Protein

Peripheral plasma membrane protein CASK

Gene

CASK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity).

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Note: Unlike other protein kinases, does not require a divalent cation such as magnesium for catalytic activity.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Differs from archetypal CaMK members in that the kinase domain exhibits a constitutively active conformation and the autoinhibitory region does not engage in direct contact with the ATP-binding cleft, although it still binds Ca2+/CAM.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Kinetics of autophosphorylation assay were measured, rather than phosphorylation of an exogenous substrate.
  1. KM=563 µM for ATP1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei41ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei141By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi18 – 26ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.11.1, 2681
2.7.4.8, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
O14936

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212676, Dopamine Neurotransmitter Release Cycle
R-HSA-3000170, Syndecan interactions
R-HSA-373753, Nephrin family interactions
R-HSA-6794361, Neurexins and neuroligins
R-HSA-9609736, Assembly and cell surface presentation of NMDA receptors
R-HSA-9662360, Sensory processing of sound by inner hair cells of the cochlea
R-HSA-9662361, Sensory processing of sound by outer hair cells of the cochlea

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
O14936

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
O14936

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O14936

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peripheral plasma membrane protein CASK (EC:2.7.11.1)
Short name:
hCASK
Alternative name(s):
Calcium/calmodulin-dependent serine protein kinase
Protein lin-2 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CASK
Synonyms:LIN2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1497, CASK

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300172, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O14936

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000147044

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mental retardation and microcephaly with pontine and cerebellar hypoplasia (MICPCH)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Affected individuals can manifest a severe phenotype consisting of severe intellectual deficit, congenital or postnatal microcephaly, disproportionate brainstem and cerebellar hypoplasia. A milder phenotype consists of mental retardation alone or associated with nystagmus.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_062996268Y → H in MICPCH. 1 PublicationCorresponds to variant dbSNP:rs137852817EnsemblClinVar.1
Natural variantiVAR_062997396P → S in MICPCH. 1 PublicationCorresponds to variant dbSNP:rs137852820EnsemblClinVar.1
Natural variantiVAR_062998710D → G in MICPCH. 1 PublicationCorresponds to variant dbSNP:rs137852818EnsemblClinVar.1
FG syndrome 4 (FGS4)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionFG syndrome (FGS) is an X-linked disorder characterized by mental retardation, relative macrocephaly, hypotonia and constipation.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05871928R → L in FGS4; does not reveal significant alterations induced by the mutation substitution; causes a partial skipping of exon 2 of the protein. 1 PublicationCorresponds to variant dbSNP:rs137852816EnsemblClinVar.1

Keywords - Diseasei

Disease variant, Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
8573

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
CASK

MalaCards human disease database

More...
MalaCardsi
CASK
MIMi300422, phenotype
300749, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000147044

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
1934, Early infantile epileptic encephalopathy
323, NON RARE IN EUROPE: FG syndrome phenotypic spectrum
163937, X-linked intellectual disability, Najm type

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26081

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O14936, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1908381

Drug and drug target database

More...
DrugBanki
DB01942, Formic acid
DB12010, Fostamatinib

DrugCentral

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DrugCentrali
O14936

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CASK

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000945681 – 926Peripheral plasma membrane protein CASKAdd BLAST926

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei51PhosphoserineCombined sources1
Modified residuei151Phosphoserine; by autocatalysis1 Publication1
Modified residuei155Phosphoserine; by autocatalysis1 Publication1
Modified residuei182PhosphothreonineBy similarity1
Modified residuei313PhosphoserineCombined sources1
Isoform 5 (identifier: O14936-5)
Modified residuei192PhosphoserineCombined sources1
Isoform 3 (identifier: O14936-3)
Modified residuei571PhosphoserineCombined sources1
Isoform 4 (identifier: O14936-4)
Modified residuei577PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O14936

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O14936

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
O14936

MaxQB - The MaxQuant DataBase

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MaxQBi
O14936

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O14936

PeptideAtlas

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PeptideAtlasi
O14936

PRoteomics IDEntifications database

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PRIDEi
O14936

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
48318 [O14936-1]
48319 [O14936-2]
48320 [O14936-3]
48321 [O14936-4]
48322 [O14936-5]
48323 [O14936-6]

Consortium for Top Down Proteomics

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TopDownProteomicsi
O14936-5 [O14936-5]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

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GlyGeni
O14936, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O14936

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O14936

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O14936

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Expression is significantly greater in brain relative to kidney, lung, and liver and in fetal brain and kidney relative to lung and liver.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000147044, Expressed in epithelium of mammary gland and 241 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O14936, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O14936, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000147044, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

CASK and LIN7 form two mutually exclusive tripartite complexes with APBA1 or CASKIN1 (By similarity).

Component of the brain-specific heterotrimeric complex (LIN-10-LIN-2-LIN-7 complex) composed of at least APBA1, CASK, and LIN7, which associates with the motor protein KIF17 to transport vesicles along microtubules (By similarity).

Forms a heterotrimeric complex with DLG1 and LIN7B via their L27 domains (By similarity).

Identified in a complex with ACTN4, IQGAP1, MAGI2, NPHS1, SPTAN1 and SPTBN1 (By similarity).

Part of a complex containing CASK, TBR1 and TSPYL2 (By similarity).

Interacts with WHRN (By similarity).

Interacts (via the PDZ, SH3 and guanylate kinase-like domains) with NRXN1 (via C-terminus) (By similarity).

Interacts with CASKIN1, APBA1, LIN7(A/B/C) and L27 domain of DLG1 and isoform 2 of DLG4 (By similarity).

Interacts with FCHSD2 (By similarity).

Interacts with KIRREL3 (PubMed:19012874).

Interacts with TBR1 (By similarity).

Interacts with TSPYL2 (By similarity).

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
114141, 131 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
O14936

Database of interacting proteins

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DIPi
DIP-38727N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
O14936

Protein interaction database and analysis system

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IntActi
O14936, 70 interactors

Molecular INTeraction database

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MINTi
O14936

STRING: functional protein association networks

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STRINGi
9606.ENSP00000367408

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
O14936

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O14936, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1926
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O14936

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
O14936

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini12 – 276Protein kinasePROSITE-ProRule annotationAdd BLAST265
Domaini343 – 398L27 1PROSITE-ProRule annotationAdd BLAST56
Domaini402 – 455L27 2PROSITE-ProRule annotationAdd BLAST54
Domaini489 – 564PDZPROSITE-ProRule annotationAdd BLAST76
Domaini612 – 682SH3PROSITE-ProRule annotationAdd BLAST71
Domaini739 – 911Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST173

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni305 – 315Calmodulin-bindingAdd BLAST11
Regioni482 – 909Required for interaction with NRXN1 (via C-terminal tail)By similarityAdd BLAST428
Regioni574 – 610DisorderedSequence analysisAdd BLAST37

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The first L27 domain binds DLG1 and the second L27 domain probably binds LIN7.By similarity
The protein kinase domain mediates the interaction with FCHSD2.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.Curated
Belongs to the MAGUK family.Curated

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0033, Eukaryota
KOG0609, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000155600

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001715_5_3_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O14936

Database of Orthologous Groups

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OrthoDBi
95102at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O14936

TreeFam database of animal gene trees

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TreeFami
TF314263

Family and domain databases

Conserved Domains Database

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CDDi
cd12081, SH3_CASK, 1 hit

Database of protein disorder

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DisProti
DP01438

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.30.42.10, 1 hit
3.40.50.300, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR035473, CASK_SH3
IPR008145, GK/Ca_channel_bsu
IPR008144, Guanylate_kin-like_dom
IPR020590, Guanylate_kinase_CS
IPR011009, Kinase-like_dom_sf
IPR014775, L27_C
IPR004172, L27_dom
IPR036892, L27_dom_sf
IPR027417, P-loop_NTPase
IPR001478, PDZ
IPR036034, PDZ_sf
IPR000719, Prot_kinase_dom
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

Pfam protein domain database

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Pfami
View protein in Pfam
PF00625, Guanylate_kin, 1 hit
PF02828, L27, 2 hits
PF00595, PDZ, 1 hit
PF00069, Pkinase, 1 hit
PF00018, SH3_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00072, GuKc, 1 hit
SM00569, L27, 2 hits
SM00228, PDZ, 1 hit
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101288, SSF101288, 2 hits
SSF50044, SSF50044, 1 hit
SSF50156, SSF50156, 1 hit
SSF52540, SSF52540, 1 hit
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00856, GUANYLATE_KINASE_1, 1 hit
PS50052, GUANYLATE_KINASE_2, 1 hit
PS51022, L27, 2 hits
PS50106, PDZ, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 17 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O14936-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADDDVLFED VYELCEVIGK GPFSVVRRCI NRETGQQFAV KIVDVAKFTS
60 70 80 90 100
SPGLSTEDLK REASICHMLK HPHIVELLET YSSDGMLYMV FEFMDGADLC
110 120 130 140 150
FEIVKRADAG FVYSEAVASH YMRQILEALR YCHDNNIIHR DVKPHCVLLA
160 170 180 190 200
SKENSAPVKL GGFGVAIQLG ESGLVAGGRV GTPHFMAPEV VKREPYGKPV
210 220 230 240 250
DVWGCGVILF ILLSGCLPFY GTKERLFEGI IKGKYKMNPR QWSHISESAK
260 270 280 290 300
DLVRRMLMLD PAERITVYEA LNHPWLKERD RYAYKIHLPE TVEQLRKFNA
310 320 330 340 350
RRKLKGAVLA AVSSHKFNSF YGDPPEELPD FSEDPTSSGL LAAERAVSQV
360 370 380 390 400
LDSLEEIHAL TDCSEKDLDF LHSVFQDQHL HTLLDLYDKI NTKSSPQIRN
410 420 430 440 450
PPSDAVQRAK EVLEEISCYP ENNDAKELKR ILTQPHFMAL LQTHDVVAHE
460 470 480 490 500
VYSDEALRVT PPPTSPYLNG DSPESANGDM DMENVTRVRL VQFQKNTDEP
510 520 530 540 550
MGITLKMNEL NHCIVARIMH GGMIHRQGTL HVGDEIREIN GISVANQTVE
560 570 580 590 600
QLQKMLREMR GSITFKIVPS YRTQSSSCER DSPSTSRQSP ANGHSSTNNS
610 620 630 640 650
VSDLPSTTQP KGRQIYVRAQ FEYDPAKDDL IPCKEAGIRF RVGDIIQIIS
660 670 680 690 700
KDDHNWWQGK LENSKNGTAG LIPSPELQEW RVACIAMEKT KQEQQASCTW
710 720 730 740 750
FGKKKKQYKD KYLAKHNAVF DQLDLVTYEE VVKLPAFKRK TLVLLGAHGV
760 770 780 790 800
GRRHIKNTLI TKHPDRFAYP IPHTTRPPKK DEENGKNYYF VSHDQMMQDI
810 820 830 840 850
SNNEYLEYGS HEDAMYGTKL ETIRKIHEQG LIAILDVEPQ ALKVLRTAEF
860 870 880 890 900
APFVVFIAAP TITPGLNEDE SLQRLQKESD ILQRTYAHYF DLTIINNEID
910 920
ETIRHLEEAV ELVCTAPQWV PVSWVY
Length:926
Mass (Da):105,123
Last modified:April 17, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6C02008CE52728BA
GO
Isoform 2 (identifier: O14936-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     719-723: Missing.

Show »
Length:921
Mass (Da):104,520
Checksum:iC3C9FAE8D051AA27
GO
Isoform 3 (identifier: O14936-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     340-345: Missing.
     580-602: Missing.

Show »
Length:897
Mass (Da):102,114
Checksum:i8B3BC03D2EF717CA
GO
Isoform 4 (identifier: O14936-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     580-602: Missing.
     719-723: Missing.

Show »
Length:898
Mass (Da):102,165
Checksum:iB7BC96EB46CCD791
GO
Isoform 5 (identifier: O14936-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-385: Missing.
     386-386: L → M
     580-602: Missing.

Show »
Length:518
Mass (Da):59,383
Checksum:i855EE0A1FC92D5B0
GO
Isoform 6 (identifier: O14936-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     603-614: Missing.
     719-723: Missing.

Show »
Length:909
Mass (Da):103,211
Checksum:iB0B98E6A73E36142
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 17 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y6F8A0A2R8Y6F8_HUMAN
Peripheral plasma membrane protein ...
CASK
700Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YE77A0A2R8YE77_HUMAN
Calcium/calmodulin-dependent serine...
CASK hCG_1987160
920Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JS79Q5JS79_HUMAN
Peripheral plasma membrane protein ...
CASK
927Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YEK3A0A2R8YEK3_HUMAN
Peripheral plasma membrane protein ...
CASK
955Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2U3TZM1A0A2U3TZM1_HUMAN
Peripheral plasma membrane protein ...
CASK
908Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y3B3A0A2R8Y3B3_HUMAN
Peripheral plasma membrane protein ...
CASK
394Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YFN5A0A2R8YFN5_HUMAN
Peripheral plasma membrane protein ...
CASK
904Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2U3TZM4A0A2U3TZM4_HUMAN
Peripheral plasma membrane protein ...
CASK
892Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2U3TZN6A0A2U3TZN6_HUMAN
Peripheral plasma membrane protein ...
CASK
880Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2RJN6A0A7I2RJN6_HUMAN
Peripheral plasma membrane protein ...
CASK
903Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti401P → L in AAB88198 (Ref. 2) Curated1
Sequence conflicti479D → G in AAB88125 (PubMed:9660868).Curated1
Sequence conflicti479D → G in BAB12252 (Ref. 3) Curated1
Sequence conflicti479D → G in AAU10527 (Ref. 4) Curated1
Sequence conflicti479D → G in AAF72666 (PubMed:11003712).Curated1
Sequence conflicti479D → G in AAF72667 (PubMed:11003712).Curated1
Sequence conflicti675P → S in AAB88125 (PubMed:9660868).Curated1
Sequence conflicti675P → S in AAU10527 (Ref. 4) Curated1
Sequence conflicti780K → R in AAB88125 (PubMed:9660868).Curated1
Sequence conflicti780K → R in AAU10527 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07871019 – 926Missing Probable disease-associated variant found in a patient with epilepsy and pontocerebellar hypoplasia. 1 PublicationAdd BLAST908
Natural variantiVAR_05871928R → L in FGS4; does not reveal significant alterations induced by the mutation substitution; causes a partial skipping of exon 2 of the protein. 1 PublicationCorresponds to variant dbSNP:rs137852816EnsemblClinVar.1
Natural variantiVAR_04195696G → V in a lung large cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_062996268Y → H in MICPCH. 1 PublicationCorresponds to variant dbSNP:rs137852817EnsemblClinVar.1
Natural variantiVAR_062997396P → S in MICPCH. 1 PublicationCorresponds to variant dbSNP:rs137852820EnsemblClinVar.1
Natural variantiVAR_062998710D → G in MICPCH. 1 PublicationCorresponds to variant dbSNP:rs137852818EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0244211 – 385Missing in isoform 5. 1 PublicationAdd BLAST385
Alternative sequenceiVSP_024422340 – 345Missing in isoform 3. 2 Publications6
Alternative sequenceiVSP_024423386L → M in isoform 5. 1 Publication1
Alternative sequenceiVSP_024424580 – 602Missing in isoform 3, isoform 4 and isoform 5. 4 PublicationsAdd BLAST23
Alternative sequenceiVSP_024425603 – 614Missing in isoform 6. CuratedAdd BLAST12
Alternative sequenceiVSP_024426719 – 723Missing in isoform 2, isoform 4 and isoform 6. 4 Publications5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF032119 mRNA Translation: AAB88125.1
AF035582 mRNA Translation: AAB88198.1
AB039327 mRNA Translation: BAB12252.2
AY705392 mRNA Translation: AAU10527.1
AL158144 Genomic DNA No translation available.
AL353691 Genomic DNA No translation available.
AL445239 Genomic DNA No translation available.
AL603754 Genomic DNA No translation available.
AL627402 Genomic DNA No translation available.
BC117311 mRNA Translation: AAI17312.1
BC143454 mRNA Translation: AAI43455.1
AB208859 mRNA Translation: BAD92096.1
AF262404 mRNA Translation: AAF72666.1
AF262405 mRNA Translation: AAF72667.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14257.1 [O14936-2]
CCDS48094.1 [O14936-3]
CCDS48095.1 [O14936-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001119526.1, NM_001126054.2 [O14936-4]
NP_001119527.1, NM_001126055.2 [O14936-3]
NP_003679.2, NM_003688.3 [O14936-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000378154; ENSP00000367396; ENSG00000147044 [O14936-6]
ENST00000378163; ENSP00000367405; ENSG00000147044 [O14936-1]
ENST00000644347; ENSP00000494183; ENSG00000147044 [O14936-3]
ENST00000645566; ENSP00000494788; ENSG00000147044 [O14936-2]
ENST00000646120; ENSP00000495291; ENSG00000147044 [O14936-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8573

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8573

UCSC genome browser

More...
UCSCi
uc004dfl.5, human [O14936-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF032119 mRNA Translation: AAB88125.1
AF035582 mRNA Translation: AAB88198.1
AB039327 mRNA Translation: BAB12252.2
AY705392 mRNA Translation: AAU10527.1
AL158144 Genomic DNA No translation available.
AL353691 Genomic DNA No translation available.
AL445239 Genomic DNA No translation available.
AL603754 Genomic DNA No translation available.
AL627402 Genomic DNA No translation available.
BC117311 mRNA Translation: AAI17312.1
BC143454 mRNA Translation: AAI43455.1
AB208859 mRNA Translation: BAD92096.1
AF262404 mRNA Translation: AAF72666.1
AF262405 mRNA Translation: AAF72667.1
CCDSiCCDS14257.1 [O14936-2]
CCDS48094.1 [O14936-3]
CCDS48095.1 [O14936-4]
RefSeqiNP_001119526.1, NM_001126054.2 [O14936-4]
NP_001119527.1, NM_001126055.2 [O14936-3]
NP_003679.2, NM_003688.3 [O14936-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KGDX-ray1.31A739-914[»]
1KWAX-ray1.93A/B487-572[»]
1ZL8NMR-B403-456[»]
3C0GX-ray2.19A/B1-337[»]
3C0HX-ray2.30A/B1-337[»]
3C0IX-ray1.85A1-337[»]
3MFRX-ray2.00A1-337[»]
3MFSX-ray2.10A1-337[»]
3MFTX-ray2.20A1-337[»]
3MFUX-ray2.30A1-337[»]
3TACX-ray2.20A1-345[»]
6KMHX-ray2.40A/B1-319[»]
7OAIX-ray2.30A/B/C/D1-337[»]
7OAJX-ray1.93A/B/C/D1-337[»]
7OAKX-ray2.23A/B/C/D1-337[»]
7OALX-ray2.17A/B/C/D1-337[»]
SMRiO14936
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114141, 131 interactors
CORUMiO14936
DIPiDIP-38727N
ELMiO14936
IntActiO14936, 70 interactors
MINTiO14936
STRINGi9606.ENSP00000367408

Chemistry databases

BindingDBiO14936
ChEMBLiCHEMBL1908381
DrugBankiDB01942, Formic acid
DB12010, Fostamatinib
DrugCentraliO14936

PTM databases

GlyGeniO14936, 1 site, 1 O-linked glycan (1 site)
iPTMnetiO14936
PhosphoSitePlusiO14936
SwissPalmiO14936

Genetic variation databases

BioMutaiCASK

Proteomic databases

EPDiO14936
jPOSTiO14936
MassIVEiO14936
MaxQBiO14936
PaxDbiO14936
PeptideAtlasiO14936
PRIDEiO14936
ProteomicsDBi48318 [O14936-1]
48319 [O14936-2]
48320 [O14936-3]
48321 [O14936-4]
48322 [O14936-5]
48323 [O14936-6]
TopDownProteomicsiO14936-5 [O14936-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
4529, 306 antibodies

The DNASU plasmid repository

More...
DNASUi
8573

Genome annotation databases

EnsembliENST00000378154; ENSP00000367396; ENSG00000147044 [O14936-6]
ENST00000378163; ENSP00000367405; ENSG00000147044 [O14936-1]
ENST00000644347; ENSP00000494183; ENSG00000147044 [O14936-3]
ENST00000645566; ENSP00000494788; ENSG00000147044 [O14936-2]
ENST00000646120; ENSP00000495291; ENSG00000147044 [O14936-4]
GeneIDi8573
KEGGihsa:8573
UCSCiuc004dfl.5, human [O14936-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8573
DisGeNETi8573

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CASK
GeneReviewsiCASK
HGNCiHGNC:1497, CASK
HPAiENSG00000147044, Low tissue specificity
MalaCardsiCASK
MIMi300172, gene
300422, phenotype
300749, phenotype
neXtProtiNX_O14936
OpenTargetsiENSG00000147044
Orphaneti1934, Early infantile epileptic encephalopathy
323, NON RARE IN EUROPE: FG syndrome phenotypic spectrum
163937, X-linked intellectual disability, Najm type
PharmGKBiPA26081
VEuPathDBiHostDB:ENSG00000147044

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0033, Eukaryota
KOG0609, Eukaryota
GeneTreeiENSGT00940000155600
HOGENOMiCLU_001715_5_3_1
InParanoidiO14936
OrthoDBi95102at2759
PhylomeDBiO14936
TreeFamiTF314263

Enzyme and pathway databases

BRENDAi2.7.11.1, 2681
2.7.4.8, 2681
PathwayCommonsiO14936
ReactomeiR-HSA-212676, Dopamine Neurotransmitter Release Cycle
R-HSA-3000170, Syndecan interactions
R-HSA-373753, Nephrin family interactions
R-HSA-6794361, Neurexins and neuroligins
R-HSA-9609736, Assembly and cell surface presentation of NMDA receptors
R-HSA-9662360, Sensory processing of sound by inner hair cells of the cochlea
R-HSA-9662361, Sensory processing of sound by outer hair cells of the cochlea
SABIO-RKiO14936
SignaLinkiO14936
SIGNORiO14936

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
8573, 6 hits in 667 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CASK, human
EvolutionaryTraceiO14936

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CASK

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8573
PharosiO14936, Tchem

Protein Ontology

More...
PROi
PR:O14936
RNActiO14936, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000147044, Expressed in epithelium of mammary gland and 241 other tissues
ExpressionAtlasiO14936, baseline and differential
GenevisibleiO14936, HS

Family and domain databases

CDDicd12081, SH3_CASK, 1 hit
DisProtiDP01438
Gene3Di2.30.42.10, 1 hit
3.40.50.300, 1 hit
InterProiView protein in InterPro
IPR035473, CASK_SH3
IPR008145, GK/Ca_channel_bsu
IPR008144, Guanylate_kin-like_dom
IPR020590, Guanylate_kinase_CS
IPR011009, Kinase-like_dom_sf
IPR014775, L27_C
IPR004172, L27_dom
IPR036892, L27_dom_sf
IPR027417, P-loop_NTPase
IPR001478, PDZ
IPR036034, PDZ_sf
IPR000719, Prot_kinase_dom
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PfamiView protein in Pfam
PF00625, Guanylate_kin, 1 hit
PF02828, L27, 2 hits
PF00595, PDZ, 1 hit
PF00069, Pkinase, 1 hit
PF00018, SH3_1, 1 hit
SMARTiView protein in SMART
SM00072, GuKc, 1 hit
SM00569, L27, 2 hits
SM00228, PDZ, 1 hit
SM00326, SH3, 1 hit
SUPFAMiSSF101288, SSF101288, 2 hits
SSF50044, SSF50044, 1 hit
SSF50156, SSF50156, 1 hit
SSF52540, SSF52540, 1 hit
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00856, GUANYLATE_KINASE_1, 1 hit
PS50052, GUANYLATE_KINASE_2, 1 hit
PS51022, L27, 2 hits
PS50106, PDZ, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS50002, SH3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCSKP_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O14936
Secondary accession number(s): A6NES1
, B7ZKY0, O43215, Q17RI4, Q59HA0, Q5VT16, Q5VT17, Q5VT18, Q5VT19, Q66T42, Q9BYH6, Q9NYB2, Q9NYB3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: April 17, 2007
Last modified: September 29, 2021
This is version 229 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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