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Protein

Peripheral plasma membrane protein CASK

Gene

CASK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Note: Unlike other protein kinases, does not require a divalent cation such as magnesium for catalytic activity.1 Publication

Enzyme regulationi

Differs from archetypal CaMK members in that the kinase domain exhibits a constitutively active conformation and the autoinhibitory region does not engage in direct contact with the ATP-binding cleft, although it still binds Ca2+/CAM.1 Publication

Kineticsi

Kinetics of autophosphorylation assay were measured, rather than phosphorylation of an exogenous substrate.
  1. KM=563 µM for ATP1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Binding sitei41ATPPROSITE-ProRule annotation1
    Active sitei141By similarity1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Nucleotide bindingi18 – 26ATPPROSITE-ProRule annotation9

    GO - Molecular functioni

    • ATP binding Source: UniProtKB-KW
    • calmodulin binding Source: UniProtKB-KW
    • guanylate kinase activity Source: ProtInc
    • protein serine/threonine kinase activity Source: UniProtKB-KW

    GO - Biological processi

    • cell adhesion Source: ProtInc
    • negative regulation of cell-matrix adhesion Source: BHF-UCL
    • negative regulation of cellular response to growth factor stimulus Source: BHF-UCL
    • negative regulation of keratinocyte proliferation Source: CACAO
    • negative regulation of wound healing Source: BHF-UCL
    • neurotransmitter secretion Source: Reactome

    Keywordsi

    Molecular functionCalmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase
    LigandATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.11.1 2681
    2.7.4.8 2681
    ReactomeiR-HSA-212676 Dopamine Neurotransmitter Release Cycle
    R-HSA-3000170 Syndecan interactions
    R-HSA-373753 Nephrin family interactions
    R-HSA-6794361 Neurexins and neuroligins
    SABIO-RKiO14936
    SignaLinkiO14936
    SIGNORiO14936

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peripheral plasma membrane protein CASK (EC:2.7.11.1)
    Short name:
    hCASK
    Alternative name(s):
    Calcium/calmodulin-dependent serine protein kinase
    Protein lin-2 homolog
    Gene namesi
    Name:CASK
    Synonyms:LIN2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome X

    Organism-specific databases

    EuPathDBiHostDB:ENSG00000147044.20
    HGNCiHGNC:1497 CASK
    MIMi300172 gene
    neXtProtiNX_O14936

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane, Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Mental retardation and microcephaly with pontine and cerebellar hypoplasia (MICPCH)2 Publications
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionA disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Affected individuals can manifest a severe phenotype consisting of severe intellectual deficit, congenital or postnatal microcephaly, disproportionate brainstem and cerebellar hypoplasia. A milder phenotype consists of mental retardation alone or associated with nystagmus.
    See also OMIM:300749
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_062996268Y → H in MICPCH. 1 PublicationCorresponds to variant dbSNP:rs137852817EnsemblClinVar.1
    Natural variantiVAR_062997396P → S in MICPCH. 1 PublicationCorresponds to variant dbSNP:rs137852820EnsemblClinVar.1
    Natural variantiVAR_062998710D → G in MICPCH. 1 PublicationCorresponds to variant dbSNP:rs137852818EnsemblClinVar.1
    FG syndrome 4 (FGS4)1 Publication
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionFG syndrome (FGS) is an X-linked disorder characterized by mental retardation, relative macrocephaly, hypotonia and constipation.
    See also OMIM:300422
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_05871928R → L in FGS4; does not reveal significant alterations induced by the mutation substitution; causes a partial skipping of exon 2 of the protein. 1 PublicationCorresponds to variant dbSNP:rs137852816EnsemblClinVar.1

    Keywords - Diseasei

    Disease mutation, Mental retardation

    Organism-specific databases

    DisGeNETi8573
    GeneReviewsiCASK
    MalaCardsiCASK
    MIMi300422 phenotype
    300749 phenotype
    OpenTargetsiENSG00000147044
    Orphaneti1934 Early infantile epileptic encephalopathy
    323 FG syndrome
    163937 X-linked intellectual disability, Najm type
    PharmGKBiPA26081

    Chemistry databases

    ChEMBLiCHEMBL1908381
    DrugBankiDB01942 Formic Acid
    GuidetoPHARMACOLOGYi1959

    Polymorphism and mutation databases

    BioMutaiCASK

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00000945681 – 926Peripheral plasma membrane protein CASKAdd BLAST926

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Modified residuei51PhosphoserineCombined sources1
    Modified residuei151Phosphoserine; by autocatalysis1 Publication1
    Modified residuei155Phosphoserine; by autocatalysis1 Publication1
    Modified residuei182PhosphothreonineBy similarity1
    Modified residuei313PhosphoserineCombined sources1
    Isoform 5 (identifier: O14936-5)
    Modified residuei192PhosphoserineCombined sources1
    Isoform 3 (identifier: O14936-3)
    Modified residuei571PhosphoserineCombined sources1
    Isoform 4 (identifier: O14936-4)
    Modified residuei577PhosphoserineCombined sources1

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    EPDiO14936
    MaxQBiO14936
    PaxDbiO14936
    PeptideAtlasiO14936
    PRIDEiO14936
    ProteomicsDBi48318
    48319 [O14936-2]
    48320 [O14936-3]
    48321 [O14936-4]
    48322 [O14936-5]
    48323 [O14936-6]
    TopDownProteomicsiO14936-5 [O14936-5]

    PTM databases

    iPTMnetiO14936
    PhosphoSitePlusiO14936

    Expressioni

    Tissue specificityi

    Ubiquitous. Expression is significantly greater in brain relative to kidney, lung, and liver and in fetal brain and kidney relative to lung and liver.1 Publication

    Gene expression databases

    BgeeiENSG00000147044
    CleanExiHS_CASK
    ExpressionAtlasiO14936 baseline and differential
    GenevisibleiO14936 HS

    Organism-specific databases

    HPAiCAB001949
    HPA023857

    Interactioni

    Subunit structurei

    Binds WHRN and NRXN1 cytosolic tail. Interacts with CASKIN1, APBA1, LIN7(A/B/C) and L27 domain of DLG1 and isoform 2 of DLG4 (By similarity). CASK and LIN7 form two mutually exclusive tripartite complexes with APBA1 or CASKIN1 (By similarity). Interacts with FCHSD2. Interacts with TSPYL2. Part of a complex containing CASK, TBR1 and TSPYL2 (By similarity). Identified in a complex with ACTN4, IQGAP1, MAGI2, NPHS1, SPTAN1 and SPTBN1 (By similarity). Interacts with KIRREL3.By similarity3 Publications

    Binary interactionsi

    Show more details

    GO - Molecular functioni

    Protein-protein interaction databases

    BioGridi114141, 76 interactors
    CORUMiO14936
    DIPiDIP-38727N
    ELMiO14936
    IntActiO14936, 54 interactors
    MINTiO14936
    STRINGi9606.ENSP00000367408

    Chemistry databases

    BindingDBiO14936

    Structurei

    Secondary structure

    1926
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Helixi8 – 11Combined sources4
    Beta strandi12 – 20Combined sources9
    Beta strandi22 – 31Combined sources10
    Turni32 – 34Combined sources3
    Beta strandi37 – 44Combined sources8
    Helixi45 – 49Combined sources5
    Beta strandi51 – 53Combined sources3
    Helixi56 – 68Combined sources13
    Beta strandi77 – 83Combined sources7
    Beta strandi86 – 92Combined sources7
    Helixi99 – 108Combined sources10
    Helixi115 – 134Combined sources20
    Helixi144 – 146Combined sources3
    Beta strandi147 – 149Combined sources3
    Beta strandi151 – 153Combined sources3
    Beta strandi158 – 160Combined sources3
    Helixi163 – 165Combined sources3
    Beta strandi171 – 173Combined sources3
    Helixi183 – 185Combined sources3
    Helixi188 – 191Combined sources4
    Helixi199 – 214Combined sources16
    Helixi223 – 232Combined sources10
    Helixi239 – 242Combined sources4
    Helixi247 – 256Combined sources10
    Turni261 – 263Combined sources3
    Helixi267 – 271Combined sources5
    Helixi274 – 277Combined sources4
    Helixi279 – 282Combined sources4
    Helixi289 – 302Combined sources14
    Turni304 – 306Combined sources3
    Helixi309 – 312Combined sources4
    Beta strandi314 – 316Combined sources3
    Helixi404 – 416Combined sources13
    Helixi423 – 431Combined sources9
    Helixi437 – 450Combined sources14
    Beta strandi489 – 495Combined sources7
    Beta strandi497 – 499Combined sources3
    Beta strandi503 – 506Combined sources4
    Helixi510 – 512Combined sources3
    Beta strandi513 – 518Combined sources6
    Helixi523 – 527Combined sources5
    Beta strandi535 – 539Combined sources5
    Helixi544 – 546Combined sources3
    Helixi549 – 558Combined sources10
    Beta strandi561 – 568Combined sources8
    Beta strandi741 – 745Combined sources5
    Helixi752 – 762Combined sources11
    Turni764 – 766Combined sources3
    Turni784 – 786Combined sources3
    Helixi793 – 801Combined sources9
    Beta strandi805 – 811Combined sources7
    Beta strandi814 – 819Combined sources6
    Helixi820 – 828Combined sources9
    Beta strandi832 – 836Combined sources5
    Helixi839 – 841Combined sources3
    Helixi842 – 845Combined sources4
    Turni848 – 850Combined sources3
    Beta strandi852 – 858Combined sources7
    Helixi870 – 886Combined sources17
    Helixi887 – 889Combined sources3
    Beta strandi891 – 895Combined sources5
    Helixi899 – 913Combined sources15

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1KGDX-ray1.31A739-914[»]
    1KWAX-ray1.93A/B487-572[»]
    1ZL8NMR-B403-456[»]
    3C0GX-ray2.19A/B1-337[»]
    3C0HX-ray2.30A/B1-337[»]
    3C0IX-ray1.85A1-337[»]
    3MFRX-ray2.00A1-337[»]
    3MFSX-ray2.10A1-337[»]
    3MFTX-ray2.20A1-337[»]
    3MFUX-ray2.30A1-337[»]
    3TACX-ray2.20A1-345[»]
    ProteinModelPortaliO14936
    SMRiO14936
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO14936

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Domaini12 – 276Protein kinasePROSITE-ProRule annotationAdd BLAST265
    Domaini343 – 398L27 1PROSITE-ProRule annotationAdd BLAST56
    Domaini402 – 455L27 2PROSITE-ProRule annotationAdd BLAST54
    Domaini489 – 564PDZPROSITE-ProRule annotationAdd BLAST76
    Domaini612 – 682SH3PROSITE-ProRule annotationAdd BLAST71
    Domaini739 – 911Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST173

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Regioni305 – 315Calmodulin-bindingAdd BLAST11

    Domaini

    The first L27 domain binds DLG1 and the second L27 domain probably binds LIN7.By similarity
    The protein kinase domain mediates the interaction with FCHSD2.

    Sequence similaritiesi

    In the N-terminal section; belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.Curated
    Belongs to the MAGUK family.Curated

    Keywords - Domaini

    Repeat, SH3 domain

    Phylogenomic databases

    eggNOGiKOG0033 Eukaryota
    KOG0609 Eukaryota
    COG0194 LUCA
    GeneTreeiENSGT00760000118866
    HOVERGENiHBG001858
    InParanoidiO14936
    KOiK06103
    OMAiVCTASQW
    OrthoDBiEOG091G065I
    PhylomeDBiO14936
    TreeFamiTF314263

    Family and domain databases

    CDDicd12081 SH3_CASK, 1 hit
    InterProiView protein in InterPro
    IPR035473 CASK_SH3
    IPR008145 GK/Ca_channel_bsu
    IPR008144 Guanylate_kin-like_dom
    IPR020590 Guanylate_kinase_CS
    IPR011009 Kinase-like_dom_sf
    IPR014775 L27_C
    IPR004172 L27_dom
    IPR036892 L27_dom_sf
    IPR027417 P-loop_NTPase
    IPR001478 PDZ
    IPR036034 PDZ_sf
    IPR000719 Prot_kinase_dom
    IPR036028 SH3-like_dom_sf
    IPR001452 SH3_domain
    PfamiView protein in Pfam
    PF00625 Guanylate_kin, 1 hit
    PF02828 L27, 2 hits
    PF00595 PDZ, 1 hit
    PF00069 Pkinase, 1 hit
    PF07653 SH3_2, 1 hit
    SMARTiView protein in SMART
    SM00072 GuKc, 1 hit
    SM00569 L27, 2 hits
    SM00228 PDZ, 1 hit
    SM00326 SH3, 1 hit
    SUPFAMiSSF101288 SSF101288, 2 hits
    SSF50044 SSF50044, 1 hit
    SSF50156 SSF50156, 1 hit
    SSF52540 SSF52540, 1 hit
    SSF56112 SSF56112, 1 hit
    PROSITEiView protein in PROSITE
    PS00856 GUANYLATE_KINASE_1, 1 hit
    PS50052 GUANYLATE_KINASE_2, 1 hit
    PS51022 L27, 2 hits
    PS50106 PDZ, 1 hit
    PS50011 PROTEIN_KINASE_DOM, 1 hit
    PS50002 SH3, 1 hit

    Sequences (6)i

    Sequence statusi: Complete.

    This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

    Isoform 1 (identifier: O14936-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

            10         20         30         40         50
    MADDDVLFED VYELCEVIGK GPFSVVRRCI NRETGQQFAV KIVDVAKFTS
    60 70 80 90 100
    SPGLSTEDLK REASICHMLK HPHIVELLET YSSDGMLYMV FEFMDGADLC
    110 120 130 140 150
    FEIVKRADAG FVYSEAVASH YMRQILEALR YCHDNNIIHR DVKPHCVLLA
    160 170 180 190 200
    SKENSAPVKL GGFGVAIQLG ESGLVAGGRV GTPHFMAPEV VKREPYGKPV
    210 220 230 240 250
    DVWGCGVILF ILLSGCLPFY GTKERLFEGI IKGKYKMNPR QWSHISESAK
    260 270 280 290 300
    DLVRRMLMLD PAERITVYEA LNHPWLKERD RYAYKIHLPE TVEQLRKFNA
    310 320 330 340 350
    RRKLKGAVLA AVSSHKFNSF YGDPPEELPD FSEDPTSSGL LAAERAVSQV
    360 370 380 390 400
    LDSLEEIHAL TDCSEKDLDF LHSVFQDQHL HTLLDLYDKI NTKSSPQIRN
    410 420 430 440 450
    PPSDAVQRAK EVLEEISCYP ENNDAKELKR ILTQPHFMAL LQTHDVVAHE
    460 470 480 490 500
    VYSDEALRVT PPPTSPYLNG DSPESANGDM DMENVTRVRL VQFQKNTDEP
    510 520 530 540 550
    MGITLKMNEL NHCIVARIMH GGMIHRQGTL HVGDEIREIN GISVANQTVE
    560 570 580 590 600
    QLQKMLREMR GSITFKIVPS YRTQSSSCER DSPSTSRQSP ANGHSSTNNS
    610 620 630 640 650
    VSDLPSTTQP KGRQIYVRAQ FEYDPAKDDL IPCKEAGIRF RVGDIIQIIS
    660 670 680 690 700
    KDDHNWWQGK LENSKNGTAG LIPSPELQEW RVACIAMEKT KQEQQASCTW
    710 720 730 740 750
    FGKKKKQYKD KYLAKHNAVF DQLDLVTYEE VVKLPAFKRK TLVLLGAHGV
    760 770 780 790 800
    GRRHIKNTLI TKHPDRFAYP IPHTTRPPKK DEENGKNYYF VSHDQMMQDI
    810 820 830 840 850
    SNNEYLEYGS HEDAMYGTKL ETIRKIHEQG LIAILDVEPQ ALKVLRTAEF
    860 870 880 890 900
    APFVVFIAAP TITPGLNEDE SLQRLQKESD ILQRTYAHYF DLTIINNEID
    910 920
    ETIRHLEEAV ELVCTAPQWV PVSWVY
    Length:926
    Mass (Da):105,123
    Last modified:April 17, 2007 - v3
    Checksum:i6C02008CE52728BA
    GO
    Isoform 2 (identifier: O14936-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         719-723: Missing.

    Show »
    Length:921
    Mass (Da):104,520
    Checksum:iC3C9FAE8D051AA27
    GO
    Isoform 3 (identifier: O14936-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         340-345: Missing.
         580-602: Missing.

    Show »
    Length:897
    Mass (Da):102,114
    Checksum:i8B3BC03D2EF717CA
    GO
    Isoform 4 (identifier: O14936-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         580-602: Missing.
         719-723: Missing.

    Show »
    Length:898
    Mass (Da):102,165
    Checksum:iB7BC96EB46CCD791
    GO
    Isoform 5 (identifier: O14936-5) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-385: Missing.
         386-386: L → M
         580-602: Missing.

    Show »
    Length:518
    Mass (Da):59,383
    Checksum:i855EE0A1FC92D5B0
    GO
    Isoform 6 (identifier: O14936-6) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         603-614: Missing.
         719-723: Missing.

    Note: Gene prediction confirmed by EST data.
    Show »
    Length:909
    Mass (Da):103,211
    Checksum:iB0B98E6A73E36142
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti401P → L in AAB88198 (Ref. 2) Curated1
    Sequence conflicti479D → G in AAB88125 (PubMed:9660868).Curated1
    Sequence conflicti479D → G in BAB12252 (Ref. 3) Curated1
    Sequence conflicti479D → G in AAU10527 (Ref. 4) Curated1
    Sequence conflicti479D → G in AAF72666 (PubMed:11003712).Curated1
    Sequence conflicti479D → G in AAF72667 (PubMed:11003712).Curated1
    Sequence conflicti675P → S in AAB88125 (PubMed:9660868).Curated1
    Sequence conflicti675P → S in AAU10527 (Ref. 4) Curated1
    Sequence conflicti780K → R in AAB88125 (PubMed:9660868).Curated1
    Sequence conflicti780K → R in AAU10527 (Ref. 4) Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_07871019 – 926Missing Probable disease-associated mutation found in a patient with epilepsy and pontocerebellar hypoplasia. 1 PublicationAdd BLAST908
    Natural variantiVAR_05871928R → L in FGS4; does not reveal significant alterations induced by the mutation substitution; causes a partial skipping of exon 2 of the protein. 1 PublicationCorresponds to variant dbSNP:rs137852816EnsemblClinVar.1
    Natural variantiVAR_04195696G → V in a lung large cell carcinoma sample; somatic mutation. 1 Publication1
    Natural variantiVAR_062996268Y → H in MICPCH. 1 PublicationCorresponds to variant dbSNP:rs137852817EnsemblClinVar.1
    Natural variantiVAR_062997396P → S in MICPCH. 1 PublicationCorresponds to variant dbSNP:rs137852820EnsemblClinVar.1
    Natural variantiVAR_062998710D → G in MICPCH. 1 PublicationCorresponds to variant dbSNP:rs137852818EnsemblClinVar.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Alternative sequenceiVSP_0244211 – 385Missing in isoform 5. 1 PublicationAdd BLAST385
    Alternative sequenceiVSP_024422340 – 345Missing in isoform 3. 2 Publications6
    Alternative sequenceiVSP_024423386L → M in isoform 5. 1 Publication1
    Alternative sequenceiVSP_024424580 – 602Missing in isoform 3, isoform 4 and isoform 5. 4 PublicationsAdd BLAST23
    Alternative sequenceiVSP_024425603 – 614Missing in isoform 6. CuratedAdd BLAST12
    Alternative sequenceiVSP_024426719 – 723Missing in isoform 2, isoform 4 and isoform 6. 4 Publications5

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF032119 mRNA Translation: AAB88125.1
    AF035582 mRNA Translation: AAB88198.1
    AB039327 mRNA Translation: BAB12252.2
    AY705392 mRNA Translation: AAU10527.1
    AL158144 Genomic DNA No translation available.
    AL353691 Genomic DNA No translation available.
    AL445239 Genomic DNA No translation available.
    AL603754 Genomic DNA No translation available.
    AL627402 Genomic DNA No translation available.
    BC117311 mRNA Translation: AAI17312.1
    BC143454 mRNA Translation: AAI43455.1
    AB208859 mRNA Translation: BAD92096.1
    AF262404 mRNA Translation: AAF72666.1
    AF262405 mRNA Translation: AAF72667.1
    CCDSiCCDS14257.1 [O14936-2]
    CCDS48094.1 [O14936-3]
    CCDS48095.1 [O14936-4]
    RefSeqiNP_001119526.1, NM_001126054.2 [O14936-4]
    NP_001119527.1, NM_001126055.2 [O14936-3]
    NP_003679.2, NM_003688.3 [O14936-2]
    UniGeneiHs.495984

    Genome annotation databases

    EnsembliENST00000378154; ENSP00000367396; ENSG00000147044 [O14936-6]
    ENST00000378163; ENSP00000367405; ENSG00000147044 [O14936-1]
    ENST00000421587; ENSP00000400526; ENSG00000147044 [O14936-4]
    ENST00000644347; ENSP00000494183; ENSG00000147044 [O14936-3]
    ENST00000645566; ENSP00000494788; ENSG00000147044 [O14936-2]
    GeneIDi8573
    KEGGihsa:8573
    UCSCiuc004dfl.5 human [O14936-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Similar proteinsi

    Entry informationi

    Entry nameiCSKP_HUMAN
    AccessioniPrimary (citable) accession number: O14936
    Secondary accession number(s): A6NES1
    , B7ZKY0, O43215, Q17RI4, Q59HA0, Q5VT16, Q5VT17, Q5VT18, Q5VT19, Q66T42, Q9BYH6, Q9NYB2, Q9NYB3
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: April 17, 2007
    Last modified: June 20, 2018
    This is version 205 of the entry and version 3 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    7. SIMILARITY comments
      Index of protein domains and families

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