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Protein

Regulator of G-protein signaling 12

Gene

RGS12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form.By similarity
Isoform 5: Behaves as a cell cycle-dependent transcriptional repressor, promoting inhibition of S-phase DNA synthesis.1 Publication

GO - Molecular functioni

  • GTPase activator activity Source: ProtInc
  • GTPase regulator activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionGTPase activation, Repressor, Signal transduction inhibitor
Biological processTranscription

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 12
Short name:
RGS12
Gene namesi
Name:RGS12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000159788.18
HGNCiHGNC:9994 RGS12
MIMi602512 gene
neXtProtiNX_O14924

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Nucleus, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi6002
OpenTargetsiENSG00000159788
PharmGKBiPA34364

Chemistry databases

ChEMBLiCHEMBL1293276

Polymorphism and mutation databases

BioMutaiRGS12

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002042131 – 1447Regulator of G-protein signaling 12Add BLAST1447

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei172PhosphoserineBy similarity1
Modified residuei195PhosphoserineBy similarity1
Cross-linki196Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei524Omega-N-methylarginineCombined sources1
Modified residuei633Omega-N-methylarginineBy similarity1
Modified residuei661PhosphoserineBy similarity1
Modified residuei671PhosphoserineBy similarity1
Modified residuei850PhosphoserineBy similarity1
Modified residuei879PhosphoserineBy similarity1
Modified residuei943PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO14924
MaxQBiO14924
PaxDbiO14924
PeptideAtlasiO14924
PRIDEiO14924
ProteomicsDBi48302
48303 [O14924-2]
48304 [O14924-3]
48305 [O14924-4]
TopDownProteomicsiO14924-2 [O14924-2]

PTM databases

iPTMnetiO14924
PhosphoSitePlusiO14924

Expressioni

Tissue specificityi

Isoform 3 is brain specific.

Gene expression databases

BgeeiENSG00000159788 Expressed in 194 organ(s), highest expression level in testis
CleanExiHS_RGS12
ExpressionAtlasiO14924 baseline and differential
GenevisibleiO14924 HS

Organism-specific databases

HPAiHPA054646
HPA067421

Interactioni

Subunit structurei

Interacts with GNAI1 (PubMed:18434541). Interacts with GNAI2 and GNAI3; the interactions are GDP-dependent (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi111934, 8 interactors
IntActiO14924, 2 interactors
MINTiO14924
STRINGi9606.ENSP00000339381

Structurei

Secondary structure

11447
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO14924
SMRiO14924
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO14924

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 98PDZPROSITE-ProRule annotationAdd BLAST77
Domaini228 – 340PIDPROSITE-ProRule annotationAdd BLAST113
Domaini715 – 832RGSPROSITE-ProRule annotationAdd BLAST118
Domaini962 – 1032RBD 1PROSITE-ProRule annotationAdd BLAST71
Domaini1034 – 1104RBD 2PROSITE-ProRule annotationAdd BLAST71
Domaini1187 – 1209GoLocoPROSITE-ProRule annotationAdd BLAST23

Domaini

The GoLoco domain is necessary for interaction with GNAI1, GNAI2 and GNAI3.By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000119142
HOGENOMiHOG000049111
HOVERGENiHBG061568
InParanoidiO14924
KOiK16449
OMAiSAPHPDM
OrthoDBiEOG091G0BDG
PhylomeDBiO14924
TreeFamiTF328814

Family and domain databases

CDDicd08742 RGS_RGS12, 1 hit
Gene3Di1.10.196.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR003109 GoLoco_motif
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom
IPR003116 RBD_dom
IPR016137 RGS
IPR037880 RGS12_RGS
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF02188 GoLoco, 1 hit
PF00595 PDZ, 1 hit
PF02196 RBD, 2 hits
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00390 GoLoco, 1 hit
SM00228 PDZ, 1 hit
SM00462 PTB, 1 hit
SM00455 RBD, 2 hits
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
SSF50156 SSF50156, 1 hit
SSF54236 SSF54236, 2 hits
PROSITEiView protein in PROSITE
PS50877 GOLOCO, 1 hit
PS50106 PDZ, 1 hit
PS01179 PID, 1 hit
PS50898 RBD, 2 hits
PS50132 RGS, 1 hit

Sequences (7+)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O14924-1) [UniParc]FASTAAdd to basket
Also known as: RGS12TS-L, TS, trans-spliced

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFRAGEASKR PLPGPSPPRV RSVEVARGRA GYGFTLSGQA PCVLSCVMRG
60 70 80 90 100
SPADFVGLRA GDQILAVNEI NVKKASHEDV VKLIGKCSGV LHMVIAEGVG
110 120 130 140 150
RFESCSSDEE GGLYEGKGWL KPKLDSKALG INRAERVVEE MQSGGIFNMI
160 170 180 190 200
FENPSLCASN SEPLKLKQRS LSESAATRFD VGHESINNPN PNMLSKEEIS
210 220 230 240 250
KVIHDDSVFS IGLESHDDFA LDASILNVAM IVGYLGSIEL PSTSSNLESD
260 270 280 290 300
SLQAIRGCMR RLRAEQKIHS LVTMKIMHDC VQLSTDKAGV VAEYPAEKLA
310 320 330 340 350
FSAVCPDDRR FFGLVTMQTN DDGSLAQEEE GALRTSCHVF MVDPDLFNHK
360 370 380 390 400
IHQGIARRFG FECTADPDTN GCLEFPASSL PVLQFISVLY RDMGELIEGM
410 420 430 440 450
RARAFLDGDA DAHQNNSTSS NSDSGIGNFH QEEKSNRVLV VDLGGSSSRH
460 470 480 490 500
GPGGSAWDGV GGRGAQPWGA PWTGPFCPDP EGSPPFEAAH QTDRFWDLNK
510 520 530 540 550
HLGPASPVEV PPASLRSSVP PSKRGTVGAG CGFNQRWLPV HVLREWQCGH
560 570 580 590 600
TSDQDSYTDS TDGWSSINCG TLPPPMSKIP ADRYRVEGSF AQPPLNAPKR
610 620 630 640 650
EWSRKAFGMQ SIFGPHRNVR KTKEDKKGSK FGRGTGLTQP SQRTSARRSF
660 670 680 690 700
GRSKRFSITR SLDDLESATV SDGELTGADL KDCVSNNSLS SNASLPSVQS
710 720 730 740 750
CRRLRERRVA SWAVSFERLL QDPVGVRYFS DFLRKEFSEE NILFWQACEY
760 770 780 790 800
FNHVPAHDKK ELSYRAREIF SKFLCSKATT PVNIDSQAQL ADDVLRAPHP
810 820 830 840 850
DMFKEQQLQI FNLMKFDSYT RFLKSPLYQE CILAEVEGRA LPDSQQVPSS
860 870 880 890 900
PASKHSLGSD HSSVSTPKKL SGKSKSGRSL NEELGDEDSE KKRKGAFFSW
910 920 930 940 950
SRTRSTGRSQ KKREHGDHAD DALHANGGLC RRESQGSVSS AGSLDLSEAC
960 970 980 990 1000
RTLAPEKDKA TKHCCIHLPD GTSCVVAVKA GFSIKDILSG LCERHGINGA
1010 1020 1030 1040 1050
AADLFLVGGD KPLVLHQDSS ILESRDLRLE KRTLFRLDLV PINRSVGLKA
1060 1070 1080 1090 1100
KPTKPVTEVL RPVVARYGLD LSGLLVRLSG EKEPLDLGAP ISSLDGQRVV
1110 1120 1130 1140 1150
LEEKDPSRGK ASADKQKGVP VKQNTAVNSS SRNHSATGEE RTLGKSNSIK
1160 1170 1180 1190 1200
IKGENGKNAR DPRLSKREES IAKIGKKKYQ KINLDEAEEF FELISKAQSN
1210 1220 1230 1240 1250
RADDQRGLLR KEDLVLPEFL RLPPGSTELT LPTPAAVAKG FSKRSATGNG
1260 1270 1280 1290 1300
RESASQPGEQ WEPVQESSDS PSTSPGSASS PPGPPGTTPP GQKSPSGPFC
1310 1320 1330 1340 1350
TPQSPVSLAQ EGTAQIWKRQ SQEVEAGGIQ TVEDEHVAEL TLMGEGDISS
1360 1370 1380 1390 1400
PNSTLLPPPS TPQEVPGPSR PGSGTHGSRD LPVNRIIDVD LVTGSAPGRD
1410 1420 1430 1440
GGIAGAQAGP GRSQASGGPP TSDLPGLGPV PGEPAKPKTS AHHATFV
Length:1,447
Mass (Da):156,357
Last modified:January 1, 1998 - v1
Checksum:i033CD7403DAD2725
GO
Isoform 2 (identifier: O14924-2) [UniParc]FASTAAdd to basket
Also known as: P, peripheral

The sequence of this isoform differs from the canonical sequence as follows:
     1-658: Missing.
     659-666: TRSLDDLE → MSLSLFFQ

Show »
Length:789
Mass (Da):84,894
Checksum:iEBFFA3BA3A575003
GO
Isoform 3 (identifier: O14924-3) [UniParc]FASTAAdd to basket
Also known as: B, brain

The sequence of this isoform differs from the canonical sequence as follows:
     1-647: Missing.
     648-666: RSFGRSKRFSITRSLDDLE → MNLGKELSNETHVSNDQQ

Show »
Length:799
Mass (Da):85,966
Checksum:i2B3DE78DBC475BE6
GO
Isoform 4 (identifier: O14924-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1373-1376: SGTH → TSRF
     1377-1447: Missing.

Show »
Length:1,376
Mass (Da):149,593
Checksum:iB16232931A795162
GO
Isoform 5 (identifier: O14924-5) [UniParc]FASTAAdd to basket
Also known as: RGS12TS-S

The sequence of this isoform differs from the canonical sequence as follows:
     1138-1157: GEERTLGKSNSIKIKGENGK → SFLSLFPKLRATEQMTNVGC
     1158-1447: Missing.

Show »
Length:1,157
Mass (Da):126,372
Checksum:i008E7B25C0DF3E69
GO
Isoform 6 (identifier: O14924-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MFRAGEASKRPLPGPSPPRVRSVEV → MKKHDFAENLPSSLLIIILVIFTLS
     26-627: Missing.
     1138-1157: GEERTLGKSNSIKIKGENGK → SFLSLFPKLRATEQMTNVGC
     1158-1447: Missing.

Show »
Length:555
Mass (Da):61,107
Checksum:iBBCE94518BABF917
GO
Isoform 7 (identifier: O14924-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-658: Missing.
     659-666: TRSLDDLE → MSLSLFFQ
     1138-1157: GEERTLGKSNSIKIKGENGK → SFLSLFPKLRATEQMTNVGC
     1158-1447: Missing.

Note: No experimental confirmation available.
Show »
Length:499
Mass (Da):54,909
Checksum:i19D4E54B5D47C387
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PBG5E9PBG5_HUMAN
Regulator of G-protein-signaling 12
RGS12
667Annotation score:
A0A2R8YCJ1A0A2R8YCJ1_HUMAN
Regulator of G-protein-signaling 12
RGS12
79Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti941A → V in AAI18595 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034451225I → V. Corresponds to variant dbSNP:rs7679941Ensembl.1
Natural variantiVAR_034452277M → L. Corresponds to variant dbSNP:rs16844152Ensembl.1
Natural variantiVAR_0202081124N → S. Corresponds to variant dbSNP:rs2269497Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0056821 – 658Missing in isoform 2 and isoform 7. 2 PublicationsAdd BLAST658
Alternative sequenceiVSP_0056841 – 647Missing in isoform 3. 1 PublicationAdd BLAST647
Alternative sequenceiVSP_0477411 – 25MFRAG…RSVEV → MKKHDFAENLPSSLLIIILV IFTLS in isoform 6. 2 PublicationsAdd BLAST25
Alternative sequenceiVSP_04774226 – 627Missing in isoform 6. 2 PublicationsAdd BLAST602
Alternative sequenceiVSP_005685648 – 666RSFGR…LDDLE → MNLGKELSNETHVSNDQQ in isoform 3. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_005683659 – 666TRSLDDLE → MSLSLFFQ in isoform 2 and isoform 7. 2 Publications8
Alternative sequenceiVSP_0477431138 – 1157GEERT…GENGK → SFLSLFPKLRATEQMTNVGC in isoform 5, isoform 6 and isoform 7. 3 PublicationsAdd BLAST20
Alternative sequenceiVSP_0477441158 – 1447Missing in isoform 5, isoform 6 and isoform 7. 3 PublicationsAdd BLAST290
Alternative sequenceiVSP_0056861373 – 1376SGTH → TSRF in isoform 4. 1 Publication4
Alternative sequenceiVSP_0056871377 – 1447Missing in isoform 4. 1 PublicationAdd BLAST71

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030112 mRNA Translation: AAB84187.1
AF030111 mRNA Translation: AAB84114.1
AF030110 mRNA Translation: AAB84007.1
AF030109 mRNA Translation: AAB84186.1
AF030149
, AF030151, AF030152, AF030135, AF030136, AF030137, AF030138, AF030139, AF030140, AF030141, AF030142, AF030143, AF030144, AF030145, AF030146, AF030147, AF030148 Genomic DNA Translation: AAB96645.1
AF030149
, AF030135, AF030136, AF030137, AF030138, AF030139, AF030140, AF030141, AF030142, AF030143, AF030144, AF030145, AF030146, AF030147, AF030148 Genomic DNA Translation: AAB96646.1 Sequence problems.
AF030149
, AF030134, AF030135, AF030136, AF030137, AF030138, AF030139, AF030140, AF030141, AF030142, AF030143, AF030144, AF030145, AF030146, AF030147, AF030148 Genomic DNA Translation: AAB96644.1
AF035152 mRNA Translation: AAC39835.1
AF464737 mRNA Translation: AAL69961.1
AK301510 mRNA Translation: BAH13500.1
AL590235 Genomic DNA No translation available.
AL645949 Genomic DNA No translation available.
CH471131 Genomic DNA Translation: EAW82465.1
CH471131 Genomic DNA Translation: EAW82468.1
BC118594 mRNA Translation: AAI18595.1
CH471131 Genomic DNA Translation: EAW82469.1
CH471131 Genomic DNA Translation: EAW82470.1
CCDSiCCDS3366.1 [O14924-1]
CCDS3367.1 [O14924-4]
CCDS3368.1 [O14924-3]
RefSeqiNP_002917.1, NM_002926.3 [O14924-4]
NP_937870.1, NM_198227.1 [O14924-3]
NP_937872.1, NM_198229.2 [O14924-1]
XP_006713968.1, XM_006713905.1 [O14924-1]
XP_006713969.1, XM_006713906.2 [O14924-5]
XP_006713970.1, XM_006713907.1
XP_011511845.1, XM_011513543.2
XP_016864018.1, XM_017008529.1 [O14924-1]
XP_016864020.1, XM_017008531.1
XP_016864021.1, XM_017008532.1
XP_016864022.1, XM_017008533.1
UniGeneiHs.527061

Genome annotation databases

EnsembliENST00000336727; ENSP00000338509; ENSG00000159788 [O14924-1]
ENST00000338806; ENSP00000342133; ENSG00000159788 [O14924-3]
ENST00000344733; ENSP00000339381; ENSG00000159788 [O14924-1]
ENST00000382788; ENSP00000372238; ENSG00000159788 [O14924-4]
GeneIDi6002
KEGGihsa:6002
UCSCiuc003ggw.4 human [O14924-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030112 mRNA Translation: AAB84187.1
AF030111 mRNA Translation: AAB84114.1
AF030110 mRNA Translation: AAB84007.1
AF030109 mRNA Translation: AAB84186.1
AF030149
, AF030151, AF030152, AF030135, AF030136, AF030137, AF030138, AF030139, AF030140, AF030141, AF030142, AF030143, AF030144, AF030145, AF030146, AF030147, AF030148 Genomic DNA Translation: AAB96645.1
AF030149
, AF030135, AF030136, AF030137, AF030138, AF030139, AF030140, AF030141, AF030142, AF030143, AF030144, AF030145, AF030146, AF030147, AF030148 Genomic DNA Translation: AAB96646.1 Sequence problems.
AF030149
, AF030134, AF030135, AF030136, AF030137, AF030138, AF030139, AF030140, AF030141, AF030142, AF030143, AF030144, AF030145, AF030146, AF030147, AF030148 Genomic DNA Translation: AAB96644.1
AF035152 mRNA Translation: AAC39835.1
AF464737 mRNA Translation: AAL69961.1
AK301510 mRNA Translation: BAH13500.1
AL590235 Genomic DNA No translation available.
AL645949 Genomic DNA No translation available.
CH471131 Genomic DNA Translation: EAW82465.1
CH471131 Genomic DNA Translation: EAW82468.1
BC118594 mRNA Translation: AAI18595.1
CH471131 Genomic DNA Translation: EAW82469.1
CH471131 Genomic DNA Translation: EAW82470.1
CCDSiCCDS3366.1 [O14924-1]
CCDS3367.1 [O14924-4]
CCDS3368.1 [O14924-3]
RefSeqiNP_002917.1, NM_002926.3 [O14924-4]
NP_937870.1, NM_198227.1 [O14924-3]
NP_937872.1, NM_198229.2 [O14924-1]
XP_006713968.1, XM_006713905.1 [O14924-1]
XP_006713969.1, XM_006713906.2 [O14924-5]
XP_006713970.1, XM_006713907.1
XP_011511845.1, XM_011513543.2
XP_016864018.1, XM_017008529.1 [O14924-1]
XP_016864020.1, XM_017008531.1
XP_016864021.1, XM_017008532.1
XP_016864022.1, XM_017008533.1
UniGeneiHs.527061

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EBZNMR-A705-852[»]
2KV8NMR-A18-100[»]
ProteinModelPortaliO14924
SMRiO14924
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111934, 8 interactors
IntActiO14924, 2 interactors
MINTiO14924
STRINGi9606.ENSP00000339381

Chemistry databases

ChEMBLiCHEMBL1293276

PTM databases

iPTMnetiO14924
PhosphoSitePlusiO14924

Polymorphism and mutation databases

BioMutaiRGS12

Proteomic databases

EPDiO14924
MaxQBiO14924
PaxDbiO14924
PeptideAtlasiO14924
PRIDEiO14924
ProteomicsDBi48302
48303 [O14924-2]
48304 [O14924-3]
48305 [O14924-4]
TopDownProteomicsiO14924-2 [O14924-2]

Protocols and materials databases

DNASUi6002
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336727; ENSP00000338509; ENSG00000159788 [O14924-1]
ENST00000338806; ENSP00000342133; ENSG00000159788 [O14924-3]
ENST00000344733; ENSP00000339381; ENSG00000159788 [O14924-1]
ENST00000382788; ENSP00000372238; ENSG00000159788 [O14924-4]
GeneIDi6002
KEGGihsa:6002
UCSCiuc003ggw.4 human [O14924-1]

Organism-specific databases

CTDi6002
DisGeNETi6002
EuPathDBiHostDB:ENSG00000159788.18
GeneCardsiRGS12
H-InvDBiHIX0164019
HGNCiHGNC:9994 RGS12
HPAiHPA054646
HPA067421
MIMi602512 gene
neXtProtiNX_O14924
OpenTargetsiENSG00000159788
PharmGKBiPA34364
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000119142
HOGENOMiHOG000049111
HOVERGENiHBG061568
InParanoidiO14924
KOiK16449
OMAiSAPHPDM
OrthoDBiEOG091G0BDG
PhylomeDBiO14924
TreeFamiTF328814

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events

Miscellaneous databases

ChiTaRSiRGS12 human
EvolutionaryTraceiO14924
GeneWikiiRGS12
GenomeRNAii6002
PROiPR:O14924
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000159788 Expressed in 194 organ(s), highest expression level in testis
CleanExiHS_RGS12
ExpressionAtlasiO14924 baseline and differential
GenevisibleiO14924 HS

Family and domain databases

CDDicd08742 RGS_RGS12, 1 hit
Gene3Di1.10.196.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR003109 GoLoco_motif
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom
IPR003116 RBD_dom
IPR016137 RGS
IPR037880 RGS12_RGS
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF02188 GoLoco, 1 hit
PF00595 PDZ, 1 hit
PF02196 RBD, 2 hits
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00390 GoLoco, 1 hit
SM00228 PDZ, 1 hit
SM00462 PTB, 1 hit
SM00455 RBD, 2 hits
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
SSF50156 SSF50156, 1 hit
SSF54236 SSF54236, 2 hits
PROSITEiView protein in PROSITE
PS50877 GOLOCO, 1 hit
PS50106 PDZ, 1 hit
PS01179 PID, 1 hit
PS50898 RBD, 2 hits
PS50132 RGS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRGS12_HUMAN
AccessioniPrimary (citable) accession number: O14924
Secondary accession number(s): B1AQ30
, B1AQ31, B1AQ32, B7Z764, E7EMN9, O14922, O14923, O43510, O75338, Q147X0, Q8WX95
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 172 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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