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Entry version 176 (08 May 2019)
Sequence version 1 (01 Jan 1998)
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Protein

Regulator of G-protein signaling 12

Gene

RGS12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form.By similarity
Isoform 5: Behaves as a cell cycle-dependent transcriptional repressor, promoting inhibition of S-phase DNA synthesis.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation, Repressor, Signal transduction inhibitor
Biological processTranscription

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-418594 G alpha (i) signalling events

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Regulator of G-protein signaling 12
Short name:
RGS12
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RGS12
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9994 RGS12

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602512 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O14924

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Nucleus, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6002

Open Targets

More...
OpenTargetsi
ENSG00000159788

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34364

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1293276

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RGS12

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002042131 – 1447Regulator of G-protein signaling 12Add BLAST1447

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei172PhosphoserineBy similarity1
Modified residuei195PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki196Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei524Omega-N-methylarginineCombined sources1
Modified residuei633Omega-N-methylarginineBy similarity1
Modified residuei661PhosphoserineBy similarity1
Modified residuei671PhosphoserineBy similarity1
Modified residuei850PhosphoserineBy similarity1
Modified residuei879PhosphoserineBy similarity1
Modified residuei943PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O14924

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O14924

MaxQB - The MaxQuant DataBase

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MaxQBi
O14924

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O14924

PeptideAtlas

More...
PeptideAtlasi
O14924

PRoteomics IDEntifications database

More...
PRIDEi
O14924

ProteomicsDB human proteome resource

More...
ProteomicsDBi
48302
48303 [O14924-2]
48304 [O14924-3]
48305 [O14924-4]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
O14924-2 [O14924-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O14924

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O14924

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 3 is brain specific.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000159788 Expressed in 194 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O14924 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O14924 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA054646
HPA067421

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with GNAI1 (PubMed:18434541). Interacts with GNAI2 and GNAI3; the interactions are GDP-dependent (By similarity).By similarity1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111934, 8 interactors

Protein interaction database and analysis system

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IntActi
O14924, 2 interactors

Molecular INTeraction database

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MINTi
O14924

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000339381

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11447
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EBZNMR-A705-852[»]
2KV8NMR-A18-100[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O14924

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O14924

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 98PDZPROSITE-ProRule annotationAdd BLAST77
Domaini228 – 340PIDPROSITE-ProRule annotationAdd BLAST113
Domaini715 – 832RGSPROSITE-ProRule annotationAdd BLAST118
Domaini962 – 1032RBD 1PROSITE-ProRule annotationAdd BLAST71
Domaini1034 – 1104RBD 2PROSITE-ProRule annotationAdd BLAST71
Domaini1187 – 1209GoLocoPROSITE-ProRule annotationAdd BLAST23

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The GoLoco domain is necessary for interaction with GNAI1, GNAI2 and GNAI3.By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3589 Eukaryota
ENOG410YMJD LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159741

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000049111

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O14924

KEGG Orthology (KO)

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KOi
K16449

Identification of Orthologs from Complete Genome Data

More...
OMAi
SAPHPDM

Database of Orthologous Groups

More...
OrthoDBi
275783at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O14924

TreeFam database of animal gene trees

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TreeFami
TF328814

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08742 RGS_RGS12, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.196.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003109 GoLoco_motif
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom
IPR003116 RBD_dom
IPR016137 RGS
IPR037880 RGS12_RGS
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
IPR029071 Ubiquitin-like_domsf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02188 GoLoco, 1 hit
PF00595 PDZ, 1 hit
PF02196 RBD, 2 hits
PF00615 RGS, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01301 RGSPROTEIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00390 GoLoco, 1 hit
SM00228 PDZ, 1 hit
SM00462 PTB, 1 hit
SM00455 RBD, 2 hits
SM00315 RGS, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48097 SSF48097, 1 hit
SSF50156 SSF50156, 1 hit
SSF54236 SSF54236, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50877 GOLOCO, 1 hit
PS50106 PDZ, 1 hit
PS01179 PID, 1 hit
PS50898 RBD, 2 hits
PS50132 RGS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O14924-1) [UniParc]FASTAAdd to basket
Also known as: RGS12TS-L, TS, trans-spliced

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFRAGEASKR PLPGPSPPRV RSVEVARGRA GYGFTLSGQA PCVLSCVMRG
60 70 80 90 100
SPADFVGLRA GDQILAVNEI NVKKASHEDV VKLIGKCSGV LHMVIAEGVG
110 120 130 140 150
RFESCSSDEE GGLYEGKGWL KPKLDSKALG INRAERVVEE MQSGGIFNMI
160 170 180 190 200
FENPSLCASN SEPLKLKQRS LSESAATRFD VGHESINNPN PNMLSKEEIS
210 220 230 240 250
KVIHDDSVFS IGLESHDDFA LDASILNVAM IVGYLGSIEL PSTSSNLESD
260 270 280 290 300
SLQAIRGCMR RLRAEQKIHS LVTMKIMHDC VQLSTDKAGV VAEYPAEKLA
310 320 330 340 350
FSAVCPDDRR FFGLVTMQTN DDGSLAQEEE GALRTSCHVF MVDPDLFNHK
360 370 380 390 400
IHQGIARRFG FECTADPDTN GCLEFPASSL PVLQFISVLY RDMGELIEGM
410 420 430 440 450
RARAFLDGDA DAHQNNSTSS NSDSGIGNFH QEEKSNRVLV VDLGGSSSRH
460 470 480 490 500
GPGGSAWDGV GGRGAQPWGA PWTGPFCPDP EGSPPFEAAH QTDRFWDLNK
510 520 530 540 550
HLGPASPVEV PPASLRSSVP PSKRGTVGAG CGFNQRWLPV HVLREWQCGH
560 570 580 590 600
TSDQDSYTDS TDGWSSINCG TLPPPMSKIP ADRYRVEGSF AQPPLNAPKR
610 620 630 640 650
EWSRKAFGMQ SIFGPHRNVR KTKEDKKGSK FGRGTGLTQP SQRTSARRSF
660 670 680 690 700
GRSKRFSITR SLDDLESATV SDGELTGADL KDCVSNNSLS SNASLPSVQS
710 720 730 740 750
CRRLRERRVA SWAVSFERLL QDPVGVRYFS DFLRKEFSEE NILFWQACEY
760 770 780 790 800
FNHVPAHDKK ELSYRAREIF SKFLCSKATT PVNIDSQAQL ADDVLRAPHP
810 820 830 840 850
DMFKEQQLQI FNLMKFDSYT RFLKSPLYQE CILAEVEGRA LPDSQQVPSS
860 870 880 890 900
PASKHSLGSD HSSVSTPKKL SGKSKSGRSL NEELGDEDSE KKRKGAFFSW
910 920 930 940 950
SRTRSTGRSQ KKREHGDHAD DALHANGGLC RRESQGSVSS AGSLDLSEAC
960 970 980 990 1000
RTLAPEKDKA TKHCCIHLPD GTSCVVAVKA GFSIKDILSG LCERHGINGA
1010 1020 1030 1040 1050
AADLFLVGGD KPLVLHQDSS ILESRDLRLE KRTLFRLDLV PINRSVGLKA
1060 1070 1080 1090 1100
KPTKPVTEVL RPVVARYGLD LSGLLVRLSG EKEPLDLGAP ISSLDGQRVV
1110 1120 1130 1140 1150
LEEKDPSRGK ASADKQKGVP VKQNTAVNSS SRNHSATGEE RTLGKSNSIK
1160 1170 1180 1190 1200
IKGENGKNAR DPRLSKREES IAKIGKKKYQ KINLDEAEEF FELISKAQSN
1210 1220 1230 1240 1250
RADDQRGLLR KEDLVLPEFL RLPPGSTELT LPTPAAVAKG FSKRSATGNG
1260 1270 1280 1290 1300
RESASQPGEQ WEPVQESSDS PSTSPGSASS PPGPPGTTPP GQKSPSGPFC
1310 1320 1330 1340 1350
TPQSPVSLAQ EGTAQIWKRQ SQEVEAGGIQ TVEDEHVAEL TLMGEGDISS
1360 1370 1380 1390 1400
PNSTLLPPPS TPQEVPGPSR PGSGTHGSRD LPVNRIIDVD LVTGSAPGRD
1410 1420 1430 1440
GGIAGAQAGP GRSQASGGPP TSDLPGLGPV PGEPAKPKTS AHHATFV
Length:1,447
Mass (Da):156,357
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i033CD7403DAD2725
GO
Isoform 2 (identifier: O14924-2) [UniParc]FASTAAdd to basket
Also known as: P, peripheral

The sequence of this isoform differs from the canonical sequence as follows:
     1-658: Missing.
     659-666: TRSLDDLE → MSLSLFFQ

Show »
Length:789
Mass (Da):84,894
Checksum:iEBFFA3BA3A575003
GO
Isoform 3 (identifier: O14924-3) [UniParc]FASTAAdd to basket
Also known as: B, brain

The sequence of this isoform differs from the canonical sequence as follows:
     1-647: Missing.
     648-666: RSFGRSKRFSITRSLDDLE → MNLGKELSNETHVSNDQQ

Show »
Length:799
Mass (Da):85,966
Checksum:i2B3DE78DBC475BE6
GO
Isoform 4 (identifier: O14924-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1373-1376: SGTH → TSRF
     1377-1447: Missing.

Show »
Length:1,376
Mass (Da):149,593
Checksum:iB16232931A795162
GO
Isoform 5 (identifier: O14924-5) [UniParc]FASTAAdd to basket
Also known as: RGS12TS-S

The sequence of this isoform differs from the canonical sequence as follows:
     1138-1157: GEERTLGKSNSIKIKGENGK → SFLSLFPKLRATEQMTNVGC
     1158-1447: Missing.

Show »
Length:1,157
Mass (Da):126,372
Checksum:i008E7B25C0DF3E69
GO
Isoform 6 (identifier: O14924-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MFRAGEASKRPLPGPSPPRVRSVEV → MKKHDFAENLPSSLLIIILVIFTLS
     26-627: Missing.
     1138-1157: GEERTLGKSNSIKIKGENGK → SFLSLFPKLRATEQMTNVGC
     1158-1447: Missing.

Show »
Length:555
Mass (Da):61,107
Checksum:iBBCE94518BABF917
GO
Isoform 7 (identifier: O14924-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-658: Missing.
     659-666: TRSLDDLE → MSLSLFFQ
     1138-1157: GEERTLGKSNSIKIKGENGK → SFLSLFPKLRATEQMTNVGC
     1158-1447: Missing.

Note: No experimental confirmation available.
Show »
Length:499
Mass (Da):54,909
Checksum:i19D4E54B5D47C387
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PBG5E9PBG5_HUMAN
Regulator of G-protein-signaling 12
RGS12
667Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YCJ1A0A2R8YCJ1_HUMAN
Regulator of G-protein-signaling 12
RGS12
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti941A → V in AAI18595 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034451225I → V. Corresponds to variant dbSNP:rs7679941Ensembl.1
Natural variantiVAR_034452277M → L. Corresponds to variant dbSNP:rs16844152Ensembl.1
Natural variantiVAR_0202081124N → S. Corresponds to variant dbSNP:rs2269497Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0056821 – 658Missing in isoform 2 and isoform 7. 2 PublicationsAdd BLAST658
Alternative sequenceiVSP_0056841 – 647Missing in isoform 3. 1 PublicationAdd BLAST647
Alternative sequenceiVSP_0477411 – 25MFRAG…RSVEV → MKKHDFAENLPSSLLIIILV IFTLS in isoform 6. 2 PublicationsAdd BLAST25
Alternative sequenceiVSP_04774226 – 627Missing in isoform 6. 2 PublicationsAdd BLAST602
Alternative sequenceiVSP_005685648 – 666RSFGR…LDDLE → MNLGKELSNETHVSNDQQ in isoform 3. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_005683659 – 666TRSLDDLE → MSLSLFFQ in isoform 2 and isoform 7. 2 Publications8
Alternative sequenceiVSP_0477431138 – 1157GEERT…GENGK → SFLSLFPKLRATEQMTNVGC in isoform 5, isoform 6 and isoform 7. 3 PublicationsAdd BLAST20
Alternative sequenceiVSP_0477441158 – 1447Missing in isoform 5, isoform 6 and isoform 7. 3 PublicationsAdd BLAST290
Alternative sequenceiVSP_0056861373 – 1376SGTH → TSRF in isoform 4. 1 Publication4
Alternative sequenceiVSP_0056871377 – 1447Missing in isoform 4. 1 PublicationAdd BLAST71

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF030112 mRNA Translation: AAB84187.1
AF030111 mRNA Translation: AAB84114.1
AF030110 mRNA Translation: AAB84007.1
AF030109 mRNA Translation: AAB84186.1
AF030149
, AF030151, AF030152, AF030135, AF030136, AF030137, AF030138, AF030139, AF030140, AF030141, AF030142, AF030143, AF030144, AF030145, AF030146, AF030147, AF030148 Genomic DNA Translation: AAB96645.1
AF030149
, AF030135, AF030136, AF030137, AF030138, AF030139, AF030140, AF030141, AF030142, AF030143, AF030144, AF030145, AF030146, AF030147, AF030148 Genomic DNA Translation: AAB96646.1 Sequence problems.
AF030149
, AF030134, AF030135, AF030136, AF030137, AF030138, AF030139, AF030140, AF030141, AF030142, AF030143, AF030144, AF030145, AF030146, AF030147, AF030148 Genomic DNA Translation: AAB96644.1
AF035152 mRNA Translation: AAC39835.1
AF464737 mRNA Translation: AAL69961.1
AK301510 mRNA Translation: BAH13500.1
AL590235 Genomic DNA No translation available.
AL645949 Genomic DNA No translation available.
CH471131 Genomic DNA Translation: EAW82465.1
CH471131 Genomic DNA Translation: EAW82468.1
BC118594 mRNA Translation: AAI18595.1
CH471131 Genomic DNA Translation: EAW82469.1
CH471131 Genomic DNA Translation: EAW82470.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3366.1 [O14924-1]
CCDS3367.1 [O14924-4]
CCDS3368.1 [O14924-3]

NCBI Reference Sequences

More...
RefSeqi
NP_002917.1, NM_002926.3 [O14924-4]
NP_937870.1, NM_198227.1 [O14924-3]
NP_937872.1, NM_198229.2 [O14924-1]
XP_006713968.1, XM_006713905.1 [O14924-1]
XP_006713969.1, XM_006713906.2 [O14924-5]
XP_006713970.1, XM_006713907.1
XP_011511845.1, XM_011513543.2
XP_016864018.1, XM_017008529.1 [O14924-1]
XP_016864020.1, XM_017008531.1
XP_016864021.1, XM_017008532.1
XP_016864022.1, XM_017008533.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000336727; ENSP00000338509; ENSG00000159788 [O14924-1]
ENST00000338806; ENSP00000342133; ENSG00000159788 [O14924-3]
ENST00000344733; ENSP00000339381; ENSG00000159788 [O14924-1]
ENST00000382788; ENSP00000372238; ENSG00000159788 [O14924-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6002

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6002

UCSC genome browser

More...
UCSCi
uc003ggw.4 human [O14924-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030112 mRNA Translation: AAB84187.1
AF030111 mRNA Translation: AAB84114.1
AF030110 mRNA Translation: AAB84007.1
AF030109 mRNA Translation: AAB84186.1
AF030149
, AF030151, AF030152, AF030135, AF030136, AF030137, AF030138, AF030139, AF030140, AF030141, AF030142, AF030143, AF030144, AF030145, AF030146, AF030147, AF030148 Genomic DNA Translation: AAB96645.1
AF030149
, AF030135, AF030136, AF030137, AF030138, AF030139, AF030140, AF030141, AF030142, AF030143, AF030144, AF030145, AF030146, AF030147, AF030148 Genomic DNA Translation: AAB96646.1 Sequence problems.
AF030149
, AF030134, AF030135, AF030136, AF030137, AF030138, AF030139, AF030140, AF030141, AF030142, AF030143, AF030144, AF030145, AF030146, AF030147, AF030148 Genomic DNA Translation: AAB96644.1
AF035152 mRNA Translation: AAC39835.1
AF464737 mRNA Translation: AAL69961.1
AK301510 mRNA Translation: BAH13500.1
AL590235 Genomic DNA No translation available.
AL645949 Genomic DNA No translation available.
CH471131 Genomic DNA Translation: EAW82465.1
CH471131 Genomic DNA Translation: EAW82468.1
BC118594 mRNA Translation: AAI18595.1
CH471131 Genomic DNA Translation: EAW82469.1
CH471131 Genomic DNA Translation: EAW82470.1
CCDSiCCDS3366.1 [O14924-1]
CCDS3367.1 [O14924-4]
CCDS3368.1 [O14924-3]
RefSeqiNP_002917.1, NM_002926.3 [O14924-4]
NP_937870.1, NM_198227.1 [O14924-3]
NP_937872.1, NM_198229.2 [O14924-1]
XP_006713968.1, XM_006713905.1 [O14924-1]
XP_006713969.1, XM_006713906.2 [O14924-5]
XP_006713970.1, XM_006713907.1
XP_011511845.1, XM_011513543.2
XP_016864018.1, XM_017008529.1 [O14924-1]
XP_016864020.1, XM_017008531.1
XP_016864021.1, XM_017008532.1
XP_016864022.1, XM_017008533.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EBZNMR-A705-852[»]
2KV8NMR-A18-100[»]
SMRiO14924
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111934, 8 interactors
IntActiO14924, 2 interactors
MINTiO14924
STRINGi9606.ENSP00000339381

Chemistry databases

ChEMBLiCHEMBL1293276

PTM databases

iPTMnetiO14924
PhosphoSitePlusiO14924

Polymorphism and mutation databases

BioMutaiRGS12

Proteomic databases

EPDiO14924
jPOSTiO14924
MaxQBiO14924
PaxDbiO14924
PeptideAtlasiO14924
PRIDEiO14924
ProteomicsDBi48302
48303 [O14924-2]
48304 [O14924-3]
48305 [O14924-4]
TopDownProteomicsiO14924-2 [O14924-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6002
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336727; ENSP00000338509; ENSG00000159788 [O14924-1]
ENST00000338806; ENSP00000342133; ENSG00000159788 [O14924-3]
ENST00000344733; ENSP00000339381; ENSG00000159788 [O14924-1]
ENST00000382788; ENSP00000372238; ENSG00000159788 [O14924-4]
GeneIDi6002
KEGGihsa:6002
UCSCiuc003ggw.4 human [O14924-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6002
DisGeNETi6002

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RGS12

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0164019
HGNCiHGNC:9994 RGS12
HPAiHPA054646
HPA067421
MIMi602512 gene
neXtProtiNX_O14924
OpenTargetsiENSG00000159788
PharmGKBiPA34364

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00940000159741
HOGENOMiHOG000049111
InParanoidiO14924
KOiK16449
OMAiSAPHPDM
OrthoDBi275783at2759
PhylomeDBiO14924
TreeFamiTF328814

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
RGS12 human
EvolutionaryTraceiO14924

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
RGS12

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6002

Protein Ontology

More...
PROi
PR:O14924

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000159788 Expressed in 194 organ(s), highest expression level in testis
ExpressionAtlasiO14924 baseline and differential
GenevisibleiO14924 HS

Family and domain databases

CDDicd08742 RGS_RGS12, 1 hit
Gene3Di1.10.196.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR003109 GoLoco_motif
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom
IPR003116 RBD_dom
IPR016137 RGS
IPR037880 RGS12_RGS
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF02188 GoLoco, 1 hit
PF00595 PDZ, 1 hit
PF02196 RBD, 2 hits
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00390 GoLoco, 1 hit
SM00228 PDZ, 1 hit
SM00462 PTB, 1 hit
SM00455 RBD, 2 hits
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
SSF50156 SSF50156, 1 hit
SSF54236 SSF54236, 2 hits
PROSITEiView protein in PROSITE
PS50877 GOLOCO, 1 hit
PS50106 PDZ, 1 hit
PS01179 PID, 1 hit
PS50898 RBD, 2 hits
PS50132 RGS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRGS12_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O14924
Secondary accession number(s): B1AQ30
, B1AQ31, B1AQ32, B7Z764, E7EMN9, O14922, O14923, O43510, O75338, Q147X0, Q8WX95
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: May 8, 2019
This is version 176 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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