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Protein

Regulator of G-protein signaling 13

Gene

RGS13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to both G(i)-alpha and G(q)-alpha (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionSignal transduction inhibitor

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 13
Short name:
RGS13
Gene namesi
Name:RGS13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000127074.14
HGNCiHGNC:9995 RGS13
MIMi607190 gene
neXtProtiNX_O14921

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi6003
OpenTargetsiENSG00000127074
PharmGKBiPA34365

Polymorphism and mutation databases

BioMutaiRGS13

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002042151 – 159Regulator of G-protein signaling 13Add BLAST159

Proteomic databases

MaxQBiO14921
PaxDbiO14921
PeptideAtlasiO14921
PRIDEiO14921
ProteomicsDBi48301

PTM databases

iPTMnetiO14921
PhosphoSitePlusiO14921

Expressioni

Gene expression databases

BgeeiENSG00000127074 Expressed in 99 organ(s), highest expression level in vermiform appendix
CleanExiHS_RGS13
ExpressionAtlasiO14921 baseline and differential
GenevisibleiO14921 HS

Organism-specific databases

HPAiHPA044952

Interactioni

Protein-protein interaction databases

BioGridi111935, 9 interactors
IntActiO14921, 1 interactor
STRINGi9606.ENSP00000375853

Structurei

3D structure databases

ProteinModelPortaliO14921
SMRiO14921
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 150RGSPROSITE-ProRule annotationAdd BLAST117

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000118903
HOGENOMiHOG000233513
HOVERGENiHBG013233
InParanoidiO14921
KOiK16449
OMAiIKNIQEP
OrthoDBiEOG091G0BDG
PhylomeDBiO14921
TreeFamiTF315837

Family and domain databases

Gene3Di1.10.196.10, 2 hits
InterProiView protein in InterPro
IPR016137 RGS
IPR034954 RGS13
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
PANTHERiPTHR10845:SF32 PTHR10845:SF32, 1 hit
PfamiView protein in Pfam
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
PROSITEiView protein in PROSITE
PS50132 RGS, 1 hit

Sequencei

Sequence statusi: Complete.

O14921-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRRNCWICK MCRDESKRPP SNLTLEEVLQ WAQSFENLMA TKYGPVVYAA
60 70 80 90 100
YLKMEHSDEN IQFWMACETY KKIASRWSRI SRAKKLYKIY IQPQSPREIN
110 120 130 140 150
IDSSTRETII RNIQEPTETC FEEAQKIVYM HMERDSYPRF LKSEMYQKLL

KTMQSNNSF
Length:159
Mass (Da):19,135
Last modified:January 1, 1998 - v1
Checksum:iA7AEFD70DB8450C3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034453150L → F1 PublicationCorresponds to variant dbSNP:rs16834603Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030107 mRNA Translation: AAB84000.1
AF493935 mRNA Translation: AAM12649.1
AY562947 mRNA Translation: AAS66360.1
BT006929 mRNA Translation: AAP35575.1
CR536532 mRNA Translation: CAG38769.1
AL136454 Genomic DNA No translation available.
AL596119 Genomic DNA No translation available.
BC016667 mRNA Translation: AAH16667.1
BC056866 mRNA Translation: AAH56866.2
CCDSiCCDS1376.1
RefSeqiNP_002918.1, NM_002927.4
NP_658912.1, NM_144766.2
UniGeneiHs.497220

Genome annotation databases

EnsembliENST00000391995; ENSP00000375853; ENSG00000127074
ENST00000543215; ENSP00000442837; ENSG00000127074
GeneIDi6003
KEGGihsa:6003
UCSCiuc001gsj.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030107 mRNA Translation: AAB84000.1
AF493935 mRNA Translation: AAM12649.1
AY562947 mRNA Translation: AAS66360.1
BT006929 mRNA Translation: AAP35575.1
CR536532 mRNA Translation: CAG38769.1
AL136454 Genomic DNA No translation available.
AL596119 Genomic DNA No translation available.
BC016667 mRNA Translation: AAH16667.1
BC056866 mRNA Translation: AAH56866.2
CCDSiCCDS1376.1
RefSeqiNP_002918.1, NM_002927.4
NP_658912.1, NM_144766.2
UniGeneiHs.497220

3D structure databases

ProteinModelPortaliO14921
SMRiO14921
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111935, 9 interactors
IntActiO14921, 1 interactor
STRINGi9606.ENSP00000375853

PTM databases

iPTMnetiO14921
PhosphoSitePlusiO14921

Polymorphism and mutation databases

BioMutaiRGS13

Proteomic databases

MaxQBiO14921
PaxDbiO14921
PeptideAtlasiO14921
PRIDEiO14921
ProteomicsDBi48301

Protocols and materials databases

DNASUi6003
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000391995; ENSP00000375853; ENSG00000127074
ENST00000543215; ENSP00000442837; ENSG00000127074
GeneIDi6003
KEGGihsa:6003
UCSCiuc001gsj.4 human

Organism-specific databases

CTDi6003
DisGeNETi6003
EuPathDBiHostDB:ENSG00000127074.14
GeneCardsiRGS13
HGNCiHGNC:9995 RGS13
HPAiHPA044952
MIMi607190 gene
neXtProtiNX_O14921
OpenTargetsiENSG00000127074
PharmGKBiPA34365
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3589 Eukaryota
ENOG410YMJD LUCA
GeneTreeiENSGT00760000118903
HOGENOMiHOG000233513
HOVERGENiHBG013233
InParanoidiO14921
KOiK16449
OMAiIKNIQEP
OrthoDBiEOG091G0BDG
PhylomeDBiO14921
TreeFamiTF315837

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events

Miscellaneous databases

GeneWikiiRGS13
GenomeRNAii6003
PROiPR:O14921
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000127074 Expressed in 99 organ(s), highest expression level in vermiform appendix
CleanExiHS_RGS13
ExpressionAtlasiO14921 baseline and differential
GenevisibleiO14921 HS

Family and domain databases

Gene3Di1.10.196.10, 2 hits
InterProiView protein in InterPro
IPR016137 RGS
IPR034954 RGS13
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
PANTHERiPTHR10845:SF32 PTHR10845:SF32, 1 hit
PfamiView protein in Pfam
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
PROSITEiView protein in PROSITE
PS50132 RGS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRGS13_HUMAN
AccessioniPrimary (citable) accession number: O14921
Secondary accession number(s): Q6PGR2, Q8TD63, Q9BX45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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