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UniProtKB - O14917 (PCD17_HUMAN)

Entry version 170 (10 Feb 2021)
Sequence version 2 (28 Nov 2006)
Previous versions | rss
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Protein

Protocadherin-17

Gene

PCDH17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Potential calcium-dependent cell-adhesion protein.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O14917

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protocadherin-17
Alternative name(s):
Protocadherin-68
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PCDH17
Synonyms:PCDH68, PCH68
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:14267, PCDH17

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611760, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O14917

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000118946.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini18 – 707ExtracellularSequence analysisAdd BLAST690
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei708 – 728HelicalSequence analysisAdd BLAST21
Topological domaini729 – 1159CytoplasmicSequence analysisAdd BLAST431

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		27253

Open Targets

More...OpenTargetsi		ENSG00000118946

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33001

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O14917, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PCDH17

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Sequence analysisAdd BLAST17
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000400118 – 1159Protocadherin-17Add BLAST1142

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi22N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi266N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi439N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi453N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi504N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi566N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi590N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O14917

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O14917

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O14917

MaxQB - The MaxQuant DataBase

More...MaxQBi		O14917

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O14917

PeptideAtlas

More...PeptideAtlasi		O14917

PRoteomics IDEntifications database

More...PRIDEi		O14917

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		48295 [O14917-1]
48296 [O14917-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O14917, 7 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O14917

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O14917

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O14917

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

During midgestation, enriched in the frontal and anterior temporal cortices. Expressed at high levels in the exterior margins of the thalamus, ventromedial striatal neuroepithelium and anterior cingulate.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000118946, Expressed in upper lobe of lung and 214 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O14917, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O14917, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000118946, Tissue enhanced (brain, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		118101, 13 interactors

Protein interaction database and analysis system

More...IntActi		O14917, 14 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000367151

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O14917, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O14917

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini18 – 132Cadherin 1PROSITE-ProRule annotationAdd BLAST115
Domaini133 – 243Cadherin 2PROSITE-ProRule annotationAdd BLAST111
Domaini244 – 351Cadherin 3PROSITE-ProRule annotationAdd BLAST108
Domaini353 – 472Cadherin 4PROSITE-ProRule annotationAdd BLAST120
Domaini473 – 583Cadherin 5PROSITE-ProRule annotationAdd BLAST111
Domaini589 – 695Cadherin 6PROSITE-ProRule annotationAdd BLAST107

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi186 – 188Cell attachment siteSequence analysis3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi382 – 408Gly-richAdd BLAST27

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3594, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156894

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_006480_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O14917

Identification of Orthologs from Complete Genome Data

More...OMAi		DNWPSIG

Database of Orthologous Groups

More...OrthoDBi		64478at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O14917

TreeFam database of animal gene trees

More...TreeFami		TF352008

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002126, Cadherin-like_dom
IPR015919, Cadherin-like_sf
IPR020894, Cadherin_CS
IPR013164, Cadherin_N
IPR030709, Protocadherin-17

The PANTHER Classification System

More...PANTHERi		PTHR24028:SF41, PTHR24028:SF41, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00028, Cadherin, 5 hits
PF08266, Cadherin_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00205, CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00112, CA, 6 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49313, SSF49313, 6 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00232, CADHERIN_1, 5 hits
PS50268, CADHERIN_2, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O14917-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYLSICCCFL LWAPALTLKN LNYSVPEEQG AGTVIGNIGR DARLQPGLPP 
        60         70         80         90        100
AERGGGGRSK SGSYRVLENS APHLLDVDAD SGLLYTKQRI DRESLCRHNA 
       110        120        130        140        150
KCQLSLEVFA NDKEICMIKV EIQDINDNAP SFSSDQIEMD ISENAAPGTR 
       160        170        180        190        200
FPLTSAHDPD AGENGLRTYL LTRDDHGLFG LDVKSRGDGT KFPELVIQKA 
       210        220        230        240        250
LDREQQNHHT LVLTALDGGE PPRSATVQIN VKVIDSNDNS PVFEAPSYLV 
       260        270        280        290        300
ELPENAPLGT VVIDLNATDA DEGPNGEVLY SFSSYVPDRV RELFSIDPKT 
       310        320        330        340        350
GLIRVKGNLD YEENGMLEID VQARDLGPNP IPAHCKVTVK LIDRNDNAPS 
       360        370        380        390        400
IGFVSVRQGA LSEAAPPGTV IALVRVTDRD SGKNGQLQCR VLGGGGTGGG 
       410        420        430        440        450
GGLGGPGGSV PFKLEENYDN FYTVVTDRPL DRETQDEYNV TIVARDGGSP 
       460        470        480        490        500
PLNSTKSFAI KILDENDNPP RFTKGLYVLQ VHENNIPGEY LGSVLAQDPD 
       510        520        530        540        550
LGQNGTVSYS ILPSHIGDVS IYTYVSVNPT NGAIYALRSF NFEQTKAFEF 
       560        570        580        590        600
KVLAKDSGAP AHLESNATVR VTVLDVNDNA PVIVLPTLQN DTAELQVPRN 
       610        620        630        640        650
AGLGYLVSTV RALDSDFGES GRLTYEIVDG NDDHLFEIDP SSGEIRTLHP 
       660        670        680        690        700
FWEDVTPVVE LVVKVTDHGK PTLSAVAKLI IRSVSGSLPE GVPRVNGEQH 
       710        720        730        740        750
HWDMSLPLIV TLSTISIILL AAMITIAVKC KRENKEIRTY NCRIAEYSHP 
       760        770        780        790        800
QLGGGKGKKK KINKNDIMLV QSEVEERNAM NVMNVVSSPS LATSPMYFDY 
       810        820        830        840        850
QTRLPLSSPR SEVMYLKPAS NNLTVPQGHA GCHTSFTGQG TNASETPATR 
       860        870        880        890        900
MSIIQTDNFP AEPNYMGSRQ QFVQSSSTFK DPERASLRDS GHGDSDQADS 
       910        920        930        940        950
DQDTNKGSCC DMSVREALKM KTTSTKSQPL EQEPEECVNC TDECRVLGHS 
       960        970        980        990       1000
DRCWMPQFPA ANQAENADYR TNLFVPTVEA NVETETYETV NPTGKKTFCT 
      1010       1020       1030       1040       1050
FGKDKREHTI LIANVKPYLK AKRALSPLLQ EVPSASSSPT KACIEPCTST 
      1060       1070       1080       1090       1100
KGSLDGCEAK PGALAEASSQ YLPTDSQYLS PSKQPRDPPF MASDQMARVF 
      1110       1120       1130       1140       1150
ADVHSRASRD SSEMGAVLEQ LDHPNRDLGR ESVDAEEVVR EIDKLLQDCR 

GNDPVAVRK
Length:1,159
Mass (Da):126,229
Last modified:November 28, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF687502B563B4013
GO
Isoform 2 (identifier: O14917-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     876-889: SSTFKDPERASLRD → ISVAPRLRTQKEPA
     890-1159: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:889
Mass (Da):96,570
Checksum:iE53D044E217A02CE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WXV2A0A087WXV2_HUMAN
Protocadherin-17
PCDH17
546Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X099A0A087X099_HUMAN
Protocadherin-17
PCDH17
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti139M → L in AAB84144 (Ref. 1) Curated1
Sequence conflicti256A → T in AAB84144 (Ref. 1) Curated1
Sequence conflicti330P → L in AAB84144 (Ref. 1) Curated1
Sequence conflicti430L → M in AAB84144 (Ref. 1) Curated1
Sequence conflicti489E → D in AAB84144 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_021581876 – 889SSTFK…ASLRD → ISVAPRLRTQKEPA in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_021582890 – 1159Missing in isoform 2. 1 PublicationAdd BLAST270

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF029343 mRNA Translation: AAB84144.1
AK289980 mRNA Translation: BAF82669.1
AL445216 Genomic DNA No translation available.
AL445288 Genomic DNA No translation available.
CH471124 Genomic DNA Translation: EAW52060.1
BC028165 mRNA Translation: AAH28165.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS31986.1 [O14917-1]

Protein sequence database of the Protein Information Resource

More...PIRi		T09055

NCBI Reference Sequences

More...RefSeqi		NP_001035519.1, NM_001040429.2 [O14917-1]
XP_005266414.1, XM_005266357.2 [O14917-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000377918; ENSP00000367151; ENSG00000118946 [O14917-1]
ENST00000484979; ENSP00000432899; ENSG00000118946 [O14917-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		27253

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:27253

UCSC genome browser

More...UCSCi		uc001vhq.2, human [O14917-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029343 mRNA Translation: AAB84144.1
AK289980 mRNA Translation: BAF82669.1
AL445216 Genomic DNA No translation available.
AL445288 Genomic DNA No translation available.
CH471124 Genomic DNA Translation: EAW52060.1
BC028165 mRNA Translation: AAH28165.1
CCDSiCCDS31986.1 [O14917-1]
PIRiT09055
RefSeqiNP_001035519.1, NM_001040429.2 [O14917-1]
XP_005266414.1, XM_005266357.2 [O14917-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6VFTX-ray3.71A/B/C/D18-464[»]
SMRiO14917
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi118101, 13 interactors
IntActiO14917, 14 interactors
STRINGi9606.ENSP00000367151

PTM databases

GlyGeniO14917, 7 sites
iPTMnetiO14917
PhosphoSitePlusiO14917
SwissPalmiO14917

Genetic variation databases

BioMutaiPCDH17

Proteomic databases

EPDiO14917
jPOSTiO14917
MassIVEiO14917
MaxQBiO14917
PaxDbiO14917
PeptideAtlasiO14917
PRIDEiO14917
ProteomicsDBi48295 [O14917-1]
48296 [O14917-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		9916, 148 antibodies

Genome annotation databases

EnsembliENST00000377918; ENSP00000367151; ENSG00000118946 [O14917-1]
ENST00000484979; ENSP00000432899; ENSG00000118946 [O14917-2]
GeneIDi27253
KEGGihsa:27253
UCSCiuc001vhq.2, human [O14917-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		27253
DisGeNETi27253

GeneCards: human genes, protein and diseases

More...GeneCardsi		PCDH17
HGNCiHGNC:14267, PCDH17
HPAiENSG00000118946, Tissue enhanced (brain, lymphoid tissue)
MIMi611760, gene
neXtProtiNX_O14917
OpenTargetsiENSG00000118946
PharmGKBiPA33001
VEuPathDBiHostDB:ENSG00000118946.11

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3594, Eukaryota
GeneTreeiENSGT00940000156894
HOGENOMiCLU_006480_1_1_1
InParanoidiO14917
OMAiDNWPSIG
OrthoDBi64478at2759
PhylomeDBiO14917
TreeFamiTF352008

Enzyme and pathway databases

PathwayCommonsiO14917

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		27253, 1 hit in 874 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PCDH17, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PCDH17

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		27253
PharosiO14917, Tbio

Protein Ontology

More...PROi		PR:O14917
RNActiO14917, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000118946, Expressed in upper lobe of lung and 214 other tissues
ExpressionAtlasiO14917, baseline and differential
GenevisibleiO14917, HS

Family and domain databases

InterProiView protein in InterPro
IPR002126, Cadherin-like_dom
IPR015919, Cadherin-like_sf
IPR020894, Cadherin_CS
IPR013164, Cadherin_N
IPR030709, Protocadherin-17
PANTHERiPTHR24028:SF41, PTHR24028:SF41, 1 hit
PfamiView protein in Pfam
PF00028, Cadherin, 5 hits
PF08266, Cadherin_2, 1 hit
PRINTSiPR00205, CADHERIN
SMARTiView protein in SMART
SM00112, CA, 6 hits
SUPFAMiSSF49313, SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232, CADHERIN_1, 5 hits
PS50268, CADHERIN_2, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPCD17_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O14917
Secondary accession number(s): A8K1R5, Q5VVW9, Q5VVX0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: November 28, 2006
Last modified: February 10, 2021
This is version 170 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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