UniProtKB - O14917 (PCD17_HUMAN)

BLAST

>sp|O14917|PCD17_HUMAN Protocadherin-17 OS=Homo sapiens OX=9606 GN=PCDH17 PE=2 SV=2
MYLSICCCFLLWAPALTLKNLNYSVPEEQGAGTVIGNIGRDARLQPGLPPAERGGGGRSK
SGSYRVLENSAPHLLDVDADSGLLYTKQRIDRESLCRHNAKCQLSLEVFANDKEICMIKV
EIQDINDNAPSFSSDQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTYLLTRDDHGLFG
LDVKSRGDGTKFPELVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINVKVIDSNDNS
PVFEAPSYLVELPENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDRVRELFSIDPKT
GLIRVKGNLDYEENGMLEIDVQARDLGPNPIPAHCKVTVKLIDRNDNAPSIGFVSVRQGA
LSEAAPPGTVIALVRVTDRDSGKNGQLQCRVLGGGGTGGGGGLGGPGGSVPFKLEENYDN
FYTVVTDRPLDRETQDEYNVTIVARDGGSPPLNSTKSFAIKILDENDNPPRFTKGLYVLQ
VHENNIPGEYLGSVLAQDPDLGQNGTVSYSILPSHIGDVSIYTYVSVNPTNGAIYALRSF
NFEQTKAFEFKVLAKDSGAPAHLESNATVRVTVLDVNDNAPVIVLPTLQNDTAELQVPRN
AGLGYLVSTVRALDSDFGESGRLTYEIVDGNDDHLFEIDPSSGEIRTLHPFWEDVTPVVE
LVVKVTDHGKPTLSAVAKLIIRSVSGSLPEGVPRVNGEQHHWDMSLPLIVTLSTISIILL
AAMITIAVKCKRENKEIRTYNCRIAEYSHPQLGGGKGKKKKINKNDIMLVQSEVEERNAM
NVMNVVSSPSLATSPMYFDYQTRLPLSSPRSEVMYLKPASNNLTVPQGHAGCHTSFTGQG
TNASETPATRMSIIQTDNFPAEPNYMGSRQQFVQSSSTFKDPERASLRDSGHGDSDQADS
DQDTNKGSCCDMSVREALKMKTTSTKSQPLEQEPEECVNCTDECRVLGHSDRCWMPQFPA
ANQAENADYRTNLFVPTVEANVETETYETVNPTGKKTFCTFGKDKREHTILIANVKPYLK
AKRALSPLLQEVPSASSSPTKACIEPCTSTKGSLDGCEAKPGALAEASSQYLPTDSQYLS
PSKQPRDPPFMASDQMARVFADVHSRASRDSSEMGAVLEQLDHPNRDLGRESVDAEEVVR
EIDKLLQDCRGNDPVAVRK

Align

Format
Add to basket Added to basket
History
Entry version 154 (07 Nov 2018)
Sequence version 2 (28 Nov 2006)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

Protocadherin-17

Gene

PCDH17

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

Potential calcium-dependent cell-adhesion protein.

GO - Molecular functionⁱ

calcium ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adult behavior Source: Ensembl
cell adhesion
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
negative regulation of synaptic transmission Source: Ensembl
presynaptic active zone assembly Source: Ensembl
regulation of synaptic vesicle clustering Source: Ensembl
synaptic membrane adhesion Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell adhesion
Ligand	Calcium

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protocadherin-17 Alternative name(s): Protocadherin-68
Gene namesⁱ	Name:PCDH17 Synonyms:PCDH68, PCH68
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 13

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000118946.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14267 PCDH17
MIMⁱ	611760 gene
neXtProtⁱ	NX_O14917

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	18 – 707	ExtracellularSequence analysisAdd BLAST	690
Transmembraneⁱ	708 – 728	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	729 – 1159	CytoplasmicSequence analysisAdd BLAST	431

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	27253
Open Targets More...OpenTargetsⁱ	ENSG00000118946
PharmGKBⁱ	PA33001

Polymorphism and mutation databases

BioMutaⁱ	PCDH17

BioMutaⁱ

PCDH17

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 17	Sequence analysisAdd BLAST		17
ChainⁱPRO_0000004001	18 – 1159	Protocadherin-17Add BLAST		1142

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	22	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	266	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	439	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	453	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	504	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	566	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	590	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

EPDⁱ	O14917
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O14917
PaxDbⁱ	O14917
PeptideAtlas More...PeptideAtlasⁱ	O14917
PRIDEⁱ	O14917
ProteomicsDBⁱ	48295 48296 [O14917-2]

PTM databases

iPTMnetⁱ	O14917
PhosphoSitePlusⁱ	O14917
SwissPalmⁱ	O14917

Expressionⁱ

Developmental stageⁱ

During midgestation, enriched in the frontal and anterior temporal cortices. Expressed at high levels in the exterior margins of the thalamus, ventromedial striatal neuroepithelium and anterior cingulate.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000118946 Expressed in 206 organ(s), highest expression level in upper lobe of lung
CleanExⁱ	HS_PCDH17
ExpressionAtlasⁱ	O14917 baseline and differential
Genevisibleⁱ	O14917 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA026817

HPAⁱ

HPA026817

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	118101, 9 interactors
IntActⁱ	O14917, 8 interactors

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O14917
SMRⁱ	O14917
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	18 – 132	Cadherin 1PROSITE-ProRule annotationAdd BLAST	115
Domainⁱ	133 – 243	Cadherin 2PROSITE-ProRule annotationAdd BLAST	111
Domainⁱ	244 – 351	Cadherin 3PROSITE-ProRule annotationAdd BLAST	108
Domainⁱ	353 – 472	Cadherin 4PROSITE-ProRule annotationAdd BLAST	120
Domainⁱ	473 – 583	Cadherin 5PROSITE-ProRule annotationAdd BLAST	111
Domainⁱ	589 – 695	Cadherin 6PROSITE-ProRule annotationAdd BLAST	107

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	186 – 188	Cell attachment siteSequence analysis		3

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	382 – 408	Gly-richAdd BLAST		27

Keywords - Domainⁱ

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3594 Eukaryota ENOG410XQHI LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140770
HOGENOMⁱ	HOG000220893
HOVERGENⁱ	HBG054878
InParanoidⁱ	O14917
KEGG Orthology (KO) More...KOⁱ	K16499
OMAⁱ	PQGHVGC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00QD
PhylomeDBⁱ	O14917
TreeFamⁱ	TF352008

Family and domain databases

InterProⁱ	View protein in InterPro IPR002126 Cadherin-like_dom IPR015919 Cadherin-like_sf IPR020894 Cadherin_CS IPR013164 Cadherin_N IPR030709 Protocadherin-17
PANTHERⁱ	PTHR24028:SF41 PTHR24028:SF41, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00028 Cadherin, 5 hits PF08266 Cadherin_2, 1 hit
PRINTSⁱ	PR00205 CADHERIN
SMARTⁱ	View protein in SMART SM00112 CA, 6 hits
SUPFAMⁱ	SSF49313 SSF49313, 6 hits
PROSITEⁱ	View protein in PROSITE PS00232 CADHERIN_1, 5 hits PS50268 CADHERIN_2, 6 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O14917-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYLSICCCFL LWAPALTLKN LNYSVPEEQG AGTVIGNIGR DARLQPGLPP 
        60         70         80         90        100
AERGGGGRSK SGSYRVLENS APHLLDVDAD SGLLYTKQRI DRESLCRHNA 
       110        120        130        140        150
KCQLSLEVFA NDKEICMIKV EIQDINDNAP SFSSDQIEMD ISENAAPGTR 
       160        170        180        190        200
FPLTSAHDPD AGENGLRTYL LTRDDHGLFG LDVKSRGDGT KFPELVIQKA 
       210        220        230        240        250
LDREQQNHHT LVLTALDGGE PPRSATVQIN VKVIDSNDNS PVFEAPSYLV 
       260        270        280        290        300
ELPENAPLGT VVIDLNATDA DEGPNGEVLY SFSSYVPDRV RELFSIDPKT 
       310        320        330        340        350
GLIRVKGNLD YEENGMLEID VQARDLGPNP IPAHCKVTVK LIDRNDNAPS 
       360        370        380        390        400
IGFVSVRQGA LSEAAPPGTV IALVRVTDRD SGKNGQLQCR VLGGGGTGGG 
       410        420        430        440        450
GGLGGPGGSV PFKLEENYDN FYTVVTDRPL DRETQDEYNV TIVARDGGSP 
       460        470        480        490        500
PLNSTKSFAI KILDENDNPP RFTKGLYVLQ VHENNIPGEY LGSVLAQDPD 
       510        520        530        540        550
LGQNGTVSYS ILPSHIGDVS IYTYVSVNPT NGAIYALRSF NFEQTKAFEF 
       560        570        580        590        600
KVLAKDSGAP AHLESNATVR VTVLDVNDNA PVIVLPTLQN DTAELQVPRN 
       610        620        630        640        650
AGLGYLVSTV RALDSDFGES GRLTYEIVDG NDDHLFEIDP SSGEIRTLHP 
       660        670        680        690        700
FWEDVTPVVE LVVKVTDHGK PTLSAVAKLI IRSVSGSLPE GVPRVNGEQH 
       710        720        730        740        750
HWDMSLPLIV TLSTISIILL AAMITIAVKC KRENKEIRTY NCRIAEYSHP 
       760        770        780        790        800
QLGGGKGKKK KINKNDIMLV QSEVEERNAM NVMNVVSSPS LATSPMYFDY 
       810        820        830        840        850
QTRLPLSSPR SEVMYLKPAS NNLTVPQGHA GCHTSFTGQG TNASETPATR 
       860        870        880        890        900
MSIIQTDNFP AEPNYMGSRQ QFVQSSSTFK DPERASLRDS GHGDSDQADS 
       910        920        930        940        950
DQDTNKGSCC DMSVREALKM KTTSTKSQPL EQEPEECVNC TDECRVLGHS 
       960        970        980        990       1000
DRCWMPQFPA ANQAENADYR TNLFVPTVEA NVETETYETV NPTGKKTFCT 
      1010       1020       1030       1040       1050
FGKDKREHTI LIANVKPYLK AKRALSPLLQ EVPSASSSPT KACIEPCTST 
      1060       1070       1080       1090       1100
KGSLDGCEAK PGALAEASSQ YLPTDSQYLS PSKQPRDPPF MASDQMARVF 
      1110       1120       1130       1140       1150
ADVHSRASRD SSEMGAVLEQ LDHPNRDLGR ESVDAEEVVR EIDKLLQDCR 

GNDPVAVRK

Length:1,159

Mass (Da):126,229

Last modified:November 28, 2006 - v2

Checksum:ⁱF687502B563B4013

Isoform 2 (identifier: O14917-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
876-889: SSTFKDPERASLRD → ISVAPRLRTQKEPA
890-1159: Missing.

« Hide

        10         20         30         40         50
MYLSICCCFL LWAPALTLKN LNYSVPEEQG AGTVIGNIGR DARLQPGLPP 
        60         70         80         90        100
AERGGGGRSK SGSYRVLENS APHLLDVDAD SGLLYTKQRI DRESLCRHNA 
       110        120        130        140        150
KCQLSLEVFA NDKEICMIKV EIQDINDNAP SFSSDQIEMD ISENAAPGTR 
       160        170        180        190        200
FPLTSAHDPD AGENGLRTYL LTRDDHGLFG LDVKSRGDGT KFPELVIQKA 
       210        220        230        240        250
LDREQQNHHT LVLTALDGGE PPRSATVQIN VKVIDSNDNS PVFEAPSYLV 
       260        270        280        290        300
ELPENAPLGT VVIDLNATDA DEGPNGEVLY SFSSYVPDRV RELFSIDPKT 
       310        320        330        340        350
GLIRVKGNLD YEENGMLEID VQARDLGPNP IPAHCKVTVK LIDRNDNAPS 
       360        370        380        390        400
IGFVSVRQGA LSEAAPPGTV IALVRVTDRD SGKNGQLQCR VLGGGGTGGG 
       410        420        430        440        450
GGLGGPGGSV PFKLEENYDN FYTVVTDRPL DRETQDEYNV TIVARDGGSP 
       460        470        480        490        500
PLNSTKSFAI KILDENDNPP RFTKGLYVLQ VHENNIPGEY LGSVLAQDPD 
       510        520        530        540        550
LGQNGTVSYS ILPSHIGDVS IYTYVSVNPT NGAIYALRSF NFEQTKAFEF 
       560        570        580        590        600
KVLAKDSGAP AHLESNATVR VTVLDVNDNA PVIVLPTLQN DTAELQVPRN 
       610        620        630        640        650
AGLGYLVSTV RALDSDFGES GRLTYEIVDG NDDHLFEIDP SSGEIRTLHP 
       660        670        680        690        700
FWEDVTPVVE LVVKVTDHGK PTLSAVAKLI IRSVSGSLPE GVPRVNGEQH 
       710        720        730        740        750
HWDMSLPLIV TLSTISIILL AAMITIAVKC KRENKEIRTY NCRIAEYSHP 
       760        770        780        790        800
QLGGGKGKKK KINKNDIMLV QSEVEERNAM NVMNVVSSPS LATSPMYFDY 
       810        820        830        840        850
QTRLPLSSPR SEVMYLKPAS NNLTVPQGHA GCHTSFTGQG TNASETPATR 
       860        870        880 
MSIIQTDNFP AEPNYMGSRQ QFVQSISVAP RLRTQKEPA

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »

Length:889

Mass (Da):96,570

Checksum:ⁱE53D044E217A02CE

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A087WXV2	A0A087WXV2_HUMAN	Protocadherin-17 Protocadherin-17	PCDH17	546	Annotation score:
A0A087X099	A0A087X099_HUMAN	Protocadherin-17 Protocadherin-17	PCDH17	184	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	139	M → L in AAB84144 (Ref. 1) Curated	1
Sequence conflictⁱ	256	A → T in AAB84144 (Ref. 1) Curated	1
Sequence conflictⁱ	330	P → L in AAB84144 (Ref. 1) Curated	1
Sequence conflictⁱ	430	L → M in AAB84144 (Ref. 1) Curated	1
Sequence conflictⁱ	489	E → D in AAB84144 (Ref. 1) Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_021581	876 – 889	SSTFK…ASLRD → ISVAPRLRTQKEPA in isoform 2. 1 PublicationAdd BLAST		14
Alternative sequenceⁱVSP_021582	890 – 1159	Missing in isoform 2. 1 PublicationAdd BLAST		270

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF029343 mRNA Translation: AAB84144.1 AK289980 mRNA Translation: BAF82669.1 AL445216 Genomic DNA No translation available. AL445288 Genomic DNA No translation available. CH471124 Genomic DNA Translation: EAW52060.1 BC028165 mRNA Translation: AAH28165.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31986.1 [O14917-1]
PIRⁱ	T09055
NCBI Reference Sequences More...RefSeqⁱ	NP_001035519.1, NM_001040429.2 [O14917-1] XP_005266414.1, XM_005266357.2 [O14917-1]
UniGeneⁱ	Hs.106511

Genome annotation databases

Ensemblⁱ	ENST00000377918; ENSP00000367151; ENSG00000118946 [O14917-1] ENST00000484979; ENSP00000432899; ENSG00000118946 [O14917-2]
GeneIDⁱ	27253
KEGGⁱ	hsa:27253
UCSC genome browser More...UCSCⁱ	uc001vhq.2 human [O14917-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O14917	Protocadherin 17		RAT		1208	UniRef90_O14917
Uncharacterized protein		SHEEP		1200
Protocadherin-17-like protein		CRIGR		1200
Uncharacterized protein		FELCA		1168
Uncharacterized protein		SARHA		1167
+136
O14917-2	PCDH17 isoform 2		PANTR		889	UniRef90_O14917-2
PCDH17 isoform 2		PONAB		889
UPI0008F4846D		GORGO		1089

Protein	Similar proteins		Species	Score	Length	Source
O14917	Protocadherin 17		RAT		1208	UniRef50_O14917
Uncharacterized protein		SHEEP		1200
Protocadherin-17-like protein		CRIGR		1200
Uncharacterized protein		FELCA		1168
LOW QUALITY PROTEIN: protocadherin-17-like		LIPVE		1167
+424

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF029343 mRNA Translation: AAB84144.1 AK289980 mRNA Translation: BAF82669.1 AL445216 Genomic DNA No translation available. AL445288 Genomic DNA No translation available. CH471124 Genomic DNA Translation: EAW52060.1 BC028165 mRNA Translation: AAH28165.1
CCDSⁱ	CCDS31986.1 [O14917-1]
PIRⁱ	T09055
RefSeqⁱ	NP_001035519.1, NM_001040429.2 [O14917-1] XP_005266414.1, XM_005266357.2 [O14917-1]
UniGeneⁱ	Hs.106511

3D structure databases

ProteinModelPortalⁱ	O14917
SMRⁱ	O14917
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	118101, 9 interactors
IntActⁱ	O14917, 8 interactors

PTM databases

iPTMnetⁱ	O14917
PhosphoSitePlusⁱ	O14917
SwissPalmⁱ	O14917

Polymorphism and mutation databases

BioMutaⁱ	PCDH17

BioMutaⁱ

PCDH17

Proteomic databases

EPDⁱ	O14917
MaxQBⁱ	O14917
PaxDbⁱ	O14917
PeptideAtlasⁱ	O14917
PRIDEⁱ	O14917
ProteomicsDBⁱ	48295 48296 [O14917-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000377918; ENSP00000367151; ENSG00000118946 [O14917-1] ENST00000484979; ENSP00000432899; ENSG00000118946 [O14917-2]
GeneIDⁱ	27253
KEGGⁱ	hsa:27253
UCSCⁱ	uc001vhq.2 human [O14917-1]

Organism-specific databases

CTDⁱ	27253
DisGeNETⁱ	27253
EuPathDBⁱ	HostDB:ENSG00000118946.11
GeneCardsⁱ	PCDH17
HGNCⁱ	HGNC:14267 PCDH17
HPAⁱ	HPA026817
MIMⁱ	611760 gene
neXtProtⁱ	NX_O14917
OpenTargetsⁱ	ENSG00000118946
PharmGKBⁱ	PA33001
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3594 Eukaryota ENOG410XQHI LUCA
GeneTreeⁱ	ENSGT00900000140770
HOGENOMⁱ	HOG000220893
HOVERGENⁱ	HBG054878
InParanoidⁱ	O14917
KOⁱ	K16499
OMAⁱ	PQGHVGC
OrthoDBⁱ	EOG091G00QD
PhylomeDBⁱ	O14917
TreeFamⁱ	TF352008

Miscellaneous databases

ChiTaRSⁱ	PCDH17 human
GeneWikiⁱ	PCDH17
GenomeRNAiⁱ	27253
Protein Ontology More...PROⁱ	PR:O14917
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000118946 Expressed in 206 organ(s), highest expression level in upper lobe of lung
CleanExⁱ	HS_PCDH17
ExpressionAtlasⁱ	O14917 baseline and differential
Genevisibleⁱ	O14917 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR002126 Cadherin-like_dom IPR015919 Cadherin-like_sf IPR020894 Cadherin_CS IPR013164 Cadherin_N IPR030709 Protocadherin-17
PANTHERⁱ	PTHR24028:SF41 PTHR24028:SF41, 1 hit
Pfamⁱ	View protein in Pfam PF00028 Cadherin, 5 hits PF08266 Cadherin_2, 1 hit
PRINTSⁱ	PR00205 CADHERIN
SMARTⁱ	View protein in SMART SM00112 CA, 6 hits
SUPFAMⁱ	SSF49313 SSF49313, 6 hits
PROSITEⁱ	View protein in PROSITE PS00232 CADHERIN_1, 5 hits PS50268 CADHERIN_2, 6 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PCD17_HUMAN
Accessionⁱ	O14917Primary (citable) accession number: O14917 Secondary accession number(s): A8K1R5, Q5VVW9, Q5VVX0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
	Last sequence update:	November 28, 2006
	Last modified:	November 7, 2018
	This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O14917 (PCD17_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Protocadherin-17

PCDH17

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ