Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protocadherin-17

Gene

PCDH17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin-17
Alternative name(s):
Protocadherin-68
Gene namesi
Name:PCDH17
Synonyms:PCDH68, PCH68
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000118946.11
HGNCiHGNC:14267 PCDH17
MIMi611760 gene
neXtProtiNX_O14917

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 707ExtracellularSequence analysisAdd BLAST690
Transmembranei708 – 728HelicalSequence analysisAdd BLAST21
Topological domaini729 – 1159CytoplasmicSequence analysisAdd BLAST431

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi27253
OpenTargetsiENSG00000118946
PharmGKBiPA33001

Polymorphism and mutation databases

BioMutaiPCDH17

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000000400118 – 1159Protocadherin-17Add BLAST1142

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi22N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi266N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi439N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi453N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi504N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi566N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi590N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiO14917
MaxQBiO14917
PaxDbiO14917
PeptideAtlasiO14917
PRIDEiO14917
ProteomicsDBi48295
48296 [O14917-2]

PTM databases

iPTMnetiO14917
PhosphoSitePlusiO14917
SwissPalmiO14917

Expressioni

Developmental stagei

During midgestation, enriched in the frontal and anterior temporal cortices. Expressed at high levels in the exterior margins of the thalamus, ventromedial striatal neuroepithelium and anterior cingulate.1 Publication

Gene expression databases

BgeeiENSG00000118946 Expressed in 206 organ(s), highest expression level in upper lobe of lung
CleanExiHS_PCDH17
ExpressionAtlasiO14917 baseline and differential
GenevisibleiO14917 HS

Organism-specific databases

HPAiHPA026817

Interactioni

Protein-protein interaction databases

BioGridi118101, 9 interactors
IntActiO14917, 8 interactors

Structurei

3D structure databases

ProteinModelPortaliO14917
SMRiO14917
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 132Cadherin 1PROSITE-ProRule annotationAdd BLAST115
Domaini133 – 243Cadherin 2PROSITE-ProRule annotationAdd BLAST111
Domaini244 – 351Cadherin 3PROSITE-ProRule annotationAdd BLAST108
Domaini353 – 472Cadherin 4PROSITE-ProRule annotationAdd BLAST120
Domaini473 – 583Cadherin 5PROSITE-ProRule annotationAdd BLAST111
Domaini589 – 695Cadherin 6PROSITE-ProRule annotationAdd BLAST107

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi186 – 188Cell attachment siteSequence analysis3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi382 – 408Gly-richAdd BLAST27

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00900000140770
HOGENOMiHOG000220893
HOVERGENiHBG054878
InParanoidiO14917
KOiK16499
OMAiPQGHVGC
OrthoDBiEOG091G00QD
PhylomeDBiO14917
TreeFamiTF352008

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
IPR030709 Protocadherin-17
PANTHERiPTHR24028:SF41 PTHR24028:SF41, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF08266 Cadherin_2, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 5 hits
PS50268 CADHERIN_2, 6 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O14917-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYLSICCCFL LWAPALTLKN LNYSVPEEQG AGTVIGNIGR DARLQPGLPP
60 70 80 90 100
AERGGGGRSK SGSYRVLENS APHLLDVDAD SGLLYTKQRI DRESLCRHNA
110 120 130 140 150
KCQLSLEVFA NDKEICMIKV EIQDINDNAP SFSSDQIEMD ISENAAPGTR
160 170 180 190 200
FPLTSAHDPD AGENGLRTYL LTRDDHGLFG LDVKSRGDGT KFPELVIQKA
210 220 230 240 250
LDREQQNHHT LVLTALDGGE PPRSATVQIN VKVIDSNDNS PVFEAPSYLV
260 270 280 290 300
ELPENAPLGT VVIDLNATDA DEGPNGEVLY SFSSYVPDRV RELFSIDPKT
310 320 330 340 350
GLIRVKGNLD YEENGMLEID VQARDLGPNP IPAHCKVTVK LIDRNDNAPS
360 370 380 390 400
IGFVSVRQGA LSEAAPPGTV IALVRVTDRD SGKNGQLQCR VLGGGGTGGG
410 420 430 440 450
GGLGGPGGSV PFKLEENYDN FYTVVTDRPL DRETQDEYNV TIVARDGGSP
460 470 480 490 500
PLNSTKSFAI KILDENDNPP RFTKGLYVLQ VHENNIPGEY LGSVLAQDPD
510 520 530 540 550
LGQNGTVSYS ILPSHIGDVS IYTYVSVNPT NGAIYALRSF NFEQTKAFEF
560 570 580 590 600
KVLAKDSGAP AHLESNATVR VTVLDVNDNA PVIVLPTLQN DTAELQVPRN
610 620 630 640 650
AGLGYLVSTV RALDSDFGES GRLTYEIVDG NDDHLFEIDP SSGEIRTLHP
660 670 680 690 700
FWEDVTPVVE LVVKVTDHGK PTLSAVAKLI IRSVSGSLPE GVPRVNGEQH
710 720 730 740 750
HWDMSLPLIV TLSTISIILL AAMITIAVKC KRENKEIRTY NCRIAEYSHP
760 770 780 790 800
QLGGGKGKKK KINKNDIMLV QSEVEERNAM NVMNVVSSPS LATSPMYFDY
810 820 830 840 850
QTRLPLSSPR SEVMYLKPAS NNLTVPQGHA GCHTSFTGQG TNASETPATR
860 870 880 890 900
MSIIQTDNFP AEPNYMGSRQ QFVQSSSTFK DPERASLRDS GHGDSDQADS
910 920 930 940 950
DQDTNKGSCC DMSVREALKM KTTSTKSQPL EQEPEECVNC TDECRVLGHS
960 970 980 990 1000
DRCWMPQFPA ANQAENADYR TNLFVPTVEA NVETETYETV NPTGKKTFCT
1010 1020 1030 1040 1050
FGKDKREHTI LIANVKPYLK AKRALSPLLQ EVPSASSSPT KACIEPCTST
1060 1070 1080 1090 1100
KGSLDGCEAK PGALAEASSQ YLPTDSQYLS PSKQPRDPPF MASDQMARVF
1110 1120 1130 1140 1150
ADVHSRASRD SSEMGAVLEQ LDHPNRDLGR ESVDAEEVVR EIDKLLQDCR

GNDPVAVRK
Length:1,159
Mass (Da):126,229
Last modified:November 28, 2006 - v2
Checksum:iF687502B563B4013
GO
Isoform 2 (identifier: O14917-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     876-889: SSTFKDPERASLRD → ISVAPRLRTQKEPA
     890-1159: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:889
Mass (Da):96,570
Checksum:iE53D044E217A02CE
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WXV2A0A087WXV2_HUMAN
Protocadherin-17
PCDH17
546Annotation score:
A0A087X099A0A087X099_HUMAN
Protocadherin-17
PCDH17
184Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti139M → L in AAB84144 (Ref. 1) Curated1
Sequence conflicti256A → T in AAB84144 (Ref. 1) Curated1
Sequence conflicti330P → L in AAB84144 (Ref. 1) Curated1
Sequence conflicti430L → M in AAB84144 (Ref. 1) Curated1
Sequence conflicti489E → D in AAB84144 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_021581876 – 889SSTFK…ASLRD → ISVAPRLRTQKEPA in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_021582890 – 1159Missing in isoform 2. 1 PublicationAdd BLAST270

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029343 mRNA Translation: AAB84144.1
AK289980 mRNA Translation: BAF82669.1
AL445216 Genomic DNA No translation available.
AL445288 Genomic DNA No translation available.
CH471124 Genomic DNA Translation: EAW52060.1
BC028165 mRNA Translation: AAH28165.1
CCDSiCCDS31986.1 [O14917-1]
PIRiT09055
RefSeqiNP_001035519.1, NM_001040429.2 [O14917-1]
XP_005266414.1, XM_005266357.2 [O14917-1]
UniGeneiHs.106511

Genome annotation databases

EnsembliENST00000377918; ENSP00000367151; ENSG00000118946 [O14917-1]
ENST00000484979; ENSP00000432899; ENSG00000118946 [O14917-2]
GeneIDi27253
KEGGihsa:27253
UCSCiuc001vhq.2 human [O14917-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029343 mRNA Translation: AAB84144.1
AK289980 mRNA Translation: BAF82669.1
AL445216 Genomic DNA No translation available.
AL445288 Genomic DNA No translation available.
CH471124 Genomic DNA Translation: EAW52060.1
BC028165 mRNA Translation: AAH28165.1
CCDSiCCDS31986.1 [O14917-1]
PIRiT09055
RefSeqiNP_001035519.1, NM_001040429.2 [O14917-1]
XP_005266414.1, XM_005266357.2 [O14917-1]
UniGeneiHs.106511

3D structure databases

ProteinModelPortaliO14917
SMRiO14917
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118101, 9 interactors
IntActiO14917, 8 interactors

PTM databases

iPTMnetiO14917
PhosphoSitePlusiO14917
SwissPalmiO14917

Polymorphism and mutation databases

BioMutaiPCDH17

Proteomic databases

EPDiO14917
MaxQBiO14917
PaxDbiO14917
PeptideAtlasiO14917
PRIDEiO14917
ProteomicsDBi48295
48296 [O14917-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377918; ENSP00000367151; ENSG00000118946 [O14917-1]
ENST00000484979; ENSP00000432899; ENSG00000118946 [O14917-2]
GeneIDi27253
KEGGihsa:27253
UCSCiuc001vhq.2 human [O14917-1]

Organism-specific databases

CTDi27253
DisGeNETi27253
EuPathDBiHostDB:ENSG00000118946.11
GeneCardsiPCDH17
HGNCiHGNC:14267 PCDH17
HPAiHPA026817
MIMi611760 gene
neXtProtiNX_O14917
OpenTargetsiENSG00000118946
PharmGKBiPA33001
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00900000140770
HOGENOMiHOG000220893
HOVERGENiHBG054878
InParanoidiO14917
KOiK16499
OMAiPQGHVGC
OrthoDBiEOG091G00QD
PhylomeDBiO14917
TreeFamiTF352008

Miscellaneous databases

ChiTaRSiPCDH17 human
GeneWikiiPCDH17
GenomeRNAii27253
PROiPR:O14917
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000118946 Expressed in 206 organ(s), highest expression level in upper lobe of lung
CleanExiHS_PCDH17
ExpressionAtlasiO14917 baseline and differential
GenevisibleiO14917 HS

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
IPR030709 Protocadherin-17
PANTHERiPTHR24028:SF41 PTHR24028:SF41, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF08266 Cadherin_2, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 5 hits
PS50268 CADHERIN_2, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPCD17_HUMAN
AccessioniPrimary (citable) accession number: O14917
Secondary accession number(s): A8K1R5, Q5VVW9, Q5VVX0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: November 28, 2006
Last modified: November 7, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again