UniProtKB - O14917 (PCD17_HUMAN)
Protein
Protocadherin-17
Gene
PCDH17
Organism
Homo sapiens (Human)
Status
Functioni
Potential calcium-dependent cell-adhesion protein.
GO - Molecular functioni
- calcium ion binding Source: InterPro
GO - Biological processi
- adult behavior Source: Ensembl
- cell adhesion Source: GO_Central
- homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
- negative regulation of synaptic transmission Source: Ensembl
- presynaptic active zone assembly Source: Ensembl
- regulation of synaptic vesicle clustering Source: Ensembl
- synaptic membrane adhesion Source: Ensembl
Keywordsi
Biological process | Cell adhesion |
Ligand | Calcium |
Enzyme and pathway databases
PathwayCommonsi | O14917 |
Names & Taxonomyi
Protein namesi | Recommended name: Protocadherin-17Alternative name(s): Protocadherin-68 |
Gene namesi | Name:PCDH17 Synonyms:PCDH68, PCH68 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:14267, PCDH17 |
MIMi | 611760, gene |
neXtProti | NX_O14917 |
VEuPathDBi | HostDB:ENSG00000118946.11 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein By similarity
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- integral component of postsynaptic membrane Source: Ensembl
- integral component of presynaptic membrane Source: Ensembl
Other locations
- GABA-ergic synapse Source: Ensembl
- glutamatergic synapse Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 18 – 707 | ExtracellularSequence analysisAdd BLAST | 690 | |
Transmembranei | 708 – 728 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 729 – 1159 | CytoplasmicSequence analysisAdd BLAST | 431 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 27253 |
OpenTargetsi | ENSG00000118946 |
PharmGKBi | PA33001 |
Miscellaneous databases
Pharosi | O14917, Tbio |
Genetic variation databases
BioMutai | PCDH17 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | Sequence analysisAdd BLAST | 17 | |
ChainiPRO_0000004001 | 18 – 1159 | Protocadherin-17Add BLAST | 1142 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 22 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 266 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 439 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 453 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 504 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 566 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 590 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | O14917 |
jPOSTi | O14917 |
MassIVEi | O14917 |
MaxQBi | O14917 |
PaxDbi | O14917 |
PeptideAtlasi | O14917 |
PRIDEi | O14917 |
ProteomicsDBi | 48295 [O14917-1] 48296 [O14917-2] |
PTM databases
GlyGeni | O14917, 7 sites |
iPTMneti | O14917 |
PhosphoSitePlusi | O14917 |
SwissPalmi | O14917 |
Expressioni
Developmental stagei
During midgestation, enriched in the frontal and anterior temporal cortices. Expressed at high levels in the exterior margins of the thalamus, ventromedial striatal neuroepithelium and anterior cingulate.1 Publication
Gene expression databases
Bgeei | ENSG00000118946, Expressed in upper lobe of lung and 214 other tissues |
ExpressionAtlasi | O14917, baseline and differential |
Genevisiblei | O14917, HS |
Organism-specific databases
HPAi | ENSG00000118946, Tissue enhanced (brain, lymphoid tissue) |
Interactioni
Binary interactionsi
Hide detailsO14917
With | #Exp. | IntAct |
---|---|---|
TSC22D4 [Q9Y3Q8] | 3 | EBI-947061,EBI-739485 |
YAF2 - isoform 2 [Q8IY57-5] | 3 | EBI-947061,EBI-12111538 |
Protein-protein interaction databases
BioGRIDi | 118101, 13 interactors |
IntActi | O14917, 14 interactors |
STRINGi | 9606.ENSP00000367151 |
Miscellaneous databases
RNActi | O14917, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 18 – 132 | Cadherin 1PROSITE-ProRule annotationAdd BLAST | 115 | |
Domaini | 133 – 243 | Cadherin 2PROSITE-ProRule annotationAdd BLAST | 111 | |
Domaini | 244 – 351 | Cadherin 3PROSITE-ProRule annotationAdd BLAST | 108 | |
Domaini | 353 – 472 | Cadherin 4PROSITE-ProRule annotationAdd BLAST | 120 | |
Domaini | 473 – 583 | Cadherin 5PROSITE-ProRule annotationAdd BLAST | 111 | |
Domaini | 589 – 695 | Cadherin 6PROSITE-ProRule annotationAdd BLAST | 107 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 186 – 188 | Cell attachment siteSequence analysis | 3 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 382 – 408 | Gly-richAdd BLAST | 27 |
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3594, Eukaryota |
GeneTreei | ENSGT00940000156894 |
HOGENOMi | CLU_006480_1_1_1 |
InParanoidi | O14917 |
OMAi | DNWPSIG |
OrthoDBi | 64478at2759 |
PhylomeDBi | O14917 |
TreeFami | TF352008 |
Family and domain databases
InterProi | View protein in InterPro IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR013164, Cadherin_N IPR030709, Protocadherin-17 |
PANTHERi | PTHR24028:SF41, PTHR24028:SF41, 1 hit |
Pfami | View protein in Pfam PF00028, Cadherin, 5 hits PF08266, Cadherin_2, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 6 hits |
SUPFAMi | SSF49313, SSF49313, 6 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 5 hits PS50268, CADHERIN_2, 6 hits |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O14917-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MYLSICCCFL LWAPALTLKN LNYSVPEEQG AGTVIGNIGR DARLQPGLPP
60 70 80 90 100
AERGGGGRSK SGSYRVLENS APHLLDVDAD SGLLYTKQRI DRESLCRHNA
110 120 130 140 150
KCQLSLEVFA NDKEICMIKV EIQDINDNAP SFSSDQIEMD ISENAAPGTR
160 170 180 190 200
FPLTSAHDPD AGENGLRTYL LTRDDHGLFG LDVKSRGDGT KFPELVIQKA
210 220 230 240 250
LDREQQNHHT LVLTALDGGE PPRSATVQIN VKVIDSNDNS PVFEAPSYLV
260 270 280 290 300
ELPENAPLGT VVIDLNATDA DEGPNGEVLY SFSSYVPDRV RELFSIDPKT
310 320 330 340 350
GLIRVKGNLD YEENGMLEID VQARDLGPNP IPAHCKVTVK LIDRNDNAPS
360 370 380 390 400
IGFVSVRQGA LSEAAPPGTV IALVRVTDRD SGKNGQLQCR VLGGGGTGGG
410 420 430 440 450
GGLGGPGGSV PFKLEENYDN FYTVVTDRPL DRETQDEYNV TIVARDGGSP
460 470 480 490 500
PLNSTKSFAI KILDENDNPP RFTKGLYVLQ VHENNIPGEY LGSVLAQDPD
510 520 530 540 550
LGQNGTVSYS ILPSHIGDVS IYTYVSVNPT NGAIYALRSF NFEQTKAFEF
560 570 580 590 600
KVLAKDSGAP AHLESNATVR VTVLDVNDNA PVIVLPTLQN DTAELQVPRN
610 620 630 640 650
AGLGYLVSTV RALDSDFGES GRLTYEIVDG NDDHLFEIDP SSGEIRTLHP
660 670 680 690 700
FWEDVTPVVE LVVKVTDHGK PTLSAVAKLI IRSVSGSLPE GVPRVNGEQH
710 720 730 740 750
HWDMSLPLIV TLSTISIILL AAMITIAVKC KRENKEIRTY NCRIAEYSHP
760 770 780 790 800
QLGGGKGKKK KINKNDIMLV QSEVEERNAM NVMNVVSSPS LATSPMYFDY
810 820 830 840 850
QTRLPLSSPR SEVMYLKPAS NNLTVPQGHA GCHTSFTGQG TNASETPATR
860 870 880 890 900
MSIIQTDNFP AEPNYMGSRQ QFVQSSSTFK DPERASLRDS GHGDSDQADS
910 920 930 940 950
DQDTNKGSCC DMSVREALKM KTTSTKSQPL EQEPEECVNC TDECRVLGHS
960 970 980 990 1000
DRCWMPQFPA ANQAENADYR TNLFVPTVEA NVETETYETV NPTGKKTFCT
1010 1020 1030 1040 1050
FGKDKREHTI LIANVKPYLK AKRALSPLLQ EVPSASSSPT KACIEPCTST
1060 1070 1080 1090 1100
KGSLDGCEAK PGALAEASSQ YLPTDSQYLS PSKQPRDPPF MASDQMARVF
1110 1120 1130 1140 1150
ADVHSRASRD SSEMGAVLEQ LDHPNRDLGR ESVDAEEVVR EIDKLLQDCR
GNDPVAVRK
Isoform 2 (identifier: O14917-2) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
876-889: SSTFKDPERASLRD → ISVAPRLRTQKEPA
890-1159: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WXV2 | A0A087WXV2_HUMAN | Protocadherin-17 | PCDH17 | 546 | Annotation score: | ||
A0A087X099 | A0A087X099_HUMAN | Protocadherin-17 | PCDH17 | 184 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 139 | M → L in AAB84144 (Ref. 1) Curated | 1 | |
Sequence conflicti | 256 | A → T in AAB84144 (Ref. 1) Curated | 1 | |
Sequence conflicti | 330 | P → L in AAB84144 (Ref. 1) Curated | 1 | |
Sequence conflicti | 430 | L → M in AAB84144 (Ref. 1) Curated | 1 | |
Sequence conflicti | 489 | E → D in AAB84144 (Ref. 1) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_021581 | 876 – 889 | SSTFK…ASLRD → ISVAPRLRTQKEPA in isoform 2. 1 PublicationAdd BLAST | 14 | |
Alternative sequenceiVSP_021582 | 890 – 1159 | Missing in isoform 2. 1 PublicationAdd BLAST | 270 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF029343 mRNA Translation: AAB84144.1 AK289980 mRNA Translation: BAF82669.1 AL445216 Genomic DNA No translation available. AL445288 Genomic DNA No translation available. CH471124 Genomic DNA Translation: EAW52060.1 BC028165 mRNA Translation: AAH28165.1 |
CCDSi | CCDS31986.1 [O14917-1] |
PIRi | T09055 |
RefSeqi | NP_001035519.1, NM_001040429.2 [O14917-1] XP_005266414.1, XM_005266357.2 [O14917-1] |
Genome annotation databases
Ensembli | ENST00000377918; ENSP00000367151; ENSG00000118946 [O14917-1] ENST00000484979; ENSP00000432899; ENSG00000118946 [O14917-2] |
GeneIDi | 27253 |
KEGGi | hsa:27253 |
UCSCi | uc001vhq.2, human [O14917-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF029343 mRNA Translation: AAB84144.1 AK289980 mRNA Translation: BAF82669.1 AL445216 Genomic DNA No translation available. AL445288 Genomic DNA No translation available. CH471124 Genomic DNA Translation: EAW52060.1 BC028165 mRNA Translation: AAH28165.1 |
CCDSi | CCDS31986.1 [O14917-1] |
PIRi | T09055 |
RefSeqi | NP_001035519.1, NM_001040429.2 [O14917-1] XP_005266414.1, XM_005266357.2 [O14917-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6VFT | X-ray | 3.71 | A/B/C/D | 18-464 | [»] | |
SMRi | O14917 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 118101, 13 interactors |
IntActi | O14917, 14 interactors |
STRINGi | 9606.ENSP00000367151 |
PTM databases
GlyGeni | O14917, 7 sites |
iPTMneti | O14917 |
PhosphoSitePlusi | O14917 |
SwissPalmi | O14917 |
Genetic variation databases
BioMutai | PCDH17 |
Proteomic databases
EPDi | O14917 |
jPOSTi | O14917 |
MassIVEi | O14917 |
MaxQBi | O14917 |
PaxDbi | O14917 |
PeptideAtlasi | O14917 |
PRIDEi | O14917 |
ProteomicsDBi | 48295 [O14917-1] 48296 [O14917-2] |
Protocols and materials databases
Antibodypediai | 9916, 148 antibodies |
Genome annotation databases
Ensembli | ENST00000377918; ENSP00000367151; ENSG00000118946 [O14917-1] ENST00000484979; ENSP00000432899; ENSG00000118946 [O14917-2] |
GeneIDi | 27253 |
KEGGi | hsa:27253 |
UCSCi | uc001vhq.2, human [O14917-1] |
Organism-specific databases
CTDi | 27253 |
DisGeNETi | 27253 |
GeneCardsi | PCDH17 |
HGNCi | HGNC:14267, PCDH17 |
HPAi | ENSG00000118946, Tissue enhanced (brain, lymphoid tissue) |
MIMi | 611760, gene |
neXtProti | NX_O14917 |
OpenTargetsi | ENSG00000118946 |
PharmGKBi | PA33001 |
VEuPathDBi | HostDB:ENSG00000118946.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3594, Eukaryota |
GeneTreei | ENSGT00940000156894 |
HOGENOMi | CLU_006480_1_1_1 |
InParanoidi | O14917 |
OMAi | DNWPSIG |
OrthoDBi | 64478at2759 |
PhylomeDBi | O14917 |
TreeFami | TF352008 |
Enzyme and pathway databases
PathwayCommonsi | O14917 |
Miscellaneous databases
BioGRID-ORCSi | 27253, 1 hit in 874 CRISPR screens |
ChiTaRSi | PCDH17, human |
GeneWikii | PCDH17 |
GenomeRNAii | 27253 |
Pharosi | O14917, Tbio |
PROi | PR:O14917 |
RNActi | O14917, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000118946, Expressed in upper lobe of lung and 214 other tissues |
ExpressionAtlasi | O14917, baseline and differential |
Genevisiblei | O14917, HS |
Family and domain databases
InterProi | View protein in InterPro IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR013164, Cadherin_N IPR030709, Protocadherin-17 |
PANTHERi | PTHR24028:SF41, PTHR24028:SF41, 1 hit |
Pfami | View protein in Pfam PF00028, Cadherin, 5 hits PF08266, Cadherin_2, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 6 hits |
SUPFAMi | SSF49313, SSF49313, 6 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 5 hits PS50268, CADHERIN_2, 6 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PCD17_HUMAN | |
Accessioni | O14917Primary (citable) accession number: O14917 Secondary accession number(s): A8K1R5, Q5VVW9, Q5VVX0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 16, 2004 |
Last sequence update: | November 28, 2006 | |
Last modified: | February 10, 2021 | |
This is version 170 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references