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Protein

Protein lin-7 homolog A

Gene

LIN7A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.1 Publication

GO - Molecular functioni

  • L27 domain binding Source: BHF-UCL

GO - Biological processi

  • exocytosis Source: ProtInc
  • inner ear development Source: Ensembl
  • neurotransmitter secretion Source: GO_Central
  • protein-containing complex assembly Source: ProtInc
  • protein localization to basolateral plasma membrane Source: GO_Central
  • protein transport Source: UniProtKB-KW
  • synaptic vesicle transport Source: Ensembl

Keywordsi

Biological processExocytosis, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-212676 Dopamine Neurotransmitter Release Cycle
R-HSA-6794361 Neurexins and neuroligins

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lin-7 homolog A
Short name:
Lin-7A
Short name:
hLin-7
Alternative name(s):
Mammalian lin-seven protein 1
Short name:
MALS-1
Tax interaction protein 33
Short name:
TIP-33
Vertebrate lin-7 homolog 1
Short name:
Veli-1
Gene namesi
Name:LIN7A
Synonyms:MALS1, VELI1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000111052.7
HGNCiHGNC:17787 LIN7A
MIMi603380 gene
neXtProtiNX_O14910

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse, Synaptosome, Tight junction

Pathology & Biotechi

Organism-specific databases

DisGeNETi8825
OpenTargetsiENSG00000111052
PharmGKBiPA134881936

Polymorphism and mutation databases

BioMutaiLIN7A

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001896231 – 233Protein lin-7 homolog AAdd BLAST233

Proteomic databases

EPDiO14910
MaxQBiO14910
PaxDbiO14910
PeptideAtlasiO14910
PRIDEiO14910
ProteomicsDBi48294

PTM databases

iPTMnetiO14910
PhosphoSitePlusiO14910

Expressioni

Tissue specificityi

Expressed in brain, testis, kidney, placenta and liver.1 Publication

Gene expression databases

BgeeiENSG00000111052 Expressed in 162 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_LIN7A
ExpressionAtlasiO14910 baseline and differential
GenevisibleiO14910 HS

Organism-specific databases

HPAiHPA071562

Interactioni

Subunit structurei

Forms two exclusive ternary complexes with CASK and APBA1 or CASKIN1 (By similarity). Can also interact with other modular proteins containing protein-protein interaction domains like MPP5, MPP6, MPP7, DLG1, DLG2 and DLG3 through its L27 domain. Interacts with DLG4, GRIN2B and MARCH11 as well as CDH1 and CTNNB1, the channels KCNJ12/Kir2.2, KCNJ4/Kir2.3 and probably KCNJ2/Kir2.1 and SLC6A12/BGT-1 via its PDZ domain. The association of LIN7A with cadherin and beta-catenin is calcium-dependent, occurs at synaptic junctions and requires the actin cytoskeleton. Interacts with EGFR, ERBB2, ERBB3 and ERBB4 with both PDZ and KID domains. Associates with KIF17 via APBA1. Interacts with HTR4 (By similarity). Forms a tripartite complex composed of DLG1, MPP7 and LIN7 (LIN7A or LIN7C).By similarity5 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114352, 31 interactors
CORUMiO14910
IntActiO14910, 27 interactors
MINTiO14910
STRINGi9606.ENSP00000447488

Structurei

3D structure databases

ProteinModelPortaliO14910
SMRiO14910
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 80L27PROSITE-ProRule annotationAdd BLAST56
Domaini108 – 190PDZPROSITE-ProRule annotationAdd BLAST83

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi14 – 28Kinase interacting siteAdd BLAST15

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi210 – 213Poly-Gln4
Compositional biasi217 – 229Poly-GlnAdd BLAST13

Domaini

The kinase interacting site is required for proper delivery of ERBB2 to the basolateral membrane.1 Publication
The PDZ domain regulates endocytosis and recycling of the receptor at the membrane.1 Publication
The L27 domain mediates interaction with CASK and is involved in the formation of multimeric complexes and the association of LIN7 to membranes.By similarity

Sequence similaritiesi

Belongs to the lin-7 family.Curated

Phylogenomic databases

eggNOGiKOG3550 Eukaryota
ENOG410XP5T LUCA
GeneTreeiENSGT00550000074581
HOGENOMiHOG000285929
HOVERGENiHBG052329
InParanoidiO14910
KOiK19931
OMAiVPGHKLQ
OrthoDBiEOG091G0PR4
PhylomeDBiO14910
TreeFamiTF316850

Family and domain databases

InterProiView protein in InterPro
IPR014775 L27_C
IPR004172 L27_dom
IPR036892 L27_dom_sf
IPR017365 LIN7
IPR001478 PDZ
IPR036034 PDZ_sf
PfamiView protein in Pfam
PF02828 L27, 1 hit
PF00595 PDZ, 1 hit
PIRSFiPIRSF038039 Lin-7_homologue, 1 hit
SMARTiView protein in SMART
SM00569 L27, 1 hit
SM00228 PDZ, 1 hit
SUPFAMiSSF101288 SSF101288, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS51022 L27, 1 hit
PS50106 PDZ, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O14910-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLKPSVTSAP TADMATLTVV QPLTLDRDVA RAIELLEKLQ ESGEVPVHKL
60 70 80 90 100
QSLKKVLQSE FCTAIREVYQ YMHETITVNG CPEFRARATA KATVAAFAAS
110 120 130 140 150
EGHSHPRVVE LPKTDEGLGF NVMGGKEQNS PIYISRIIPG GVAERHGGLK
160 170 180 190 200
RGDQLLSVNG VSVEGEHHEK AVELLKAAKD SVKLVVRYTP KVLEEMEARF
210 220 230
EKLRTARRRQ QQQLLIQQQQ QQQQQQTQQN HMS
Length:233
Mass (Da):25,997
Last modified:May 1, 1999 - v2
Checksum:iD8D05EF16A93BE7B
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YIA8H0YIA8_HUMAN
Protein lin-7 homolog A
LIN7A
180Annotation score:
J3KN23J3KN23_HUMAN
Protein lin-7 homolog A
LIN7A
101Annotation score:
H0YI92H0YI92_HUMAN
Protein lin-7 homolog A
LIN7A
130Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti157S → P in CAG28608 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087693 mRNA Translation: AAC78481.1
AF173081 mRNA Translation: AAD48500.1
CR407680 mRNA Translation: CAG28608.1
AK315321 mRNA Translation: BAG37724.1
BC099921 mRNA Translation: AAH99921.1
BC118609 mRNA Translation: AAI18610.1
BC122561 mRNA Translation: AAI22562.1
AF028826 mRNA Translation: AAB84251.1
CCDSiCCDS9021.1
RefSeqiNP_004655.1, NM_004664.3
UniGeneiHs.144333
Hs.586760

Genome annotation databases

EnsembliENST00000552864; ENSP00000447488; ENSG00000111052
GeneIDi8825
KEGGihsa:8825
UCSCiuc001szi.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087693 mRNA Translation: AAC78481.1
AF173081 mRNA Translation: AAD48500.1
CR407680 mRNA Translation: CAG28608.1
AK315321 mRNA Translation: BAG37724.1
BC099921 mRNA Translation: AAH99921.1
BC118609 mRNA Translation: AAI18610.1
BC122561 mRNA Translation: AAI22562.1
AF028826 mRNA Translation: AAB84251.1
CCDSiCCDS9021.1
RefSeqiNP_004655.1, NM_004664.3
UniGeneiHs.144333
Hs.586760

3D structure databases

ProteinModelPortaliO14910
SMRiO14910
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114352, 31 interactors
CORUMiO14910
IntActiO14910, 27 interactors
MINTiO14910
STRINGi9606.ENSP00000447488

PTM databases

iPTMnetiO14910
PhosphoSitePlusiO14910

Polymorphism and mutation databases

BioMutaiLIN7A

Proteomic databases

EPDiO14910
MaxQBiO14910
PaxDbiO14910
PeptideAtlasiO14910
PRIDEiO14910
ProteomicsDBi48294

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000552864; ENSP00000447488; ENSG00000111052
GeneIDi8825
KEGGihsa:8825
UCSCiuc001szi.4 human

Organism-specific databases

CTDi8825
DisGeNETi8825
EuPathDBiHostDB:ENSG00000111052.7
GeneCardsiLIN7A
HGNCiHGNC:17787 LIN7A
HPAiHPA071562
MIMi603380 gene
neXtProtiNX_O14910
OpenTargetsiENSG00000111052
PharmGKBiPA134881936
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3550 Eukaryota
ENOG410XP5T LUCA
GeneTreeiENSGT00550000074581
HOGENOMiHOG000285929
HOVERGENiHBG052329
InParanoidiO14910
KOiK19931
OMAiVPGHKLQ
OrthoDBiEOG091G0PR4
PhylomeDBiO14910
TreeFamiTF316850

Enzyme and pathway databases

ReactomeiR-HSA-212676 Dopamine Neurotransmitter Release Cycle
R-HSA-6794361 Neurexins and neuroligins

Miscellaneous databases

ChiTaRSiLIN7A human
GeneWikiiLIN7A
GenomeRNAii8825
PROiPR:O14910
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000111052 Expressed in 162 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_LIN7A
ExpressionAtlasiO14910 baseline and differential
GenevisibleiO14910 HS

Family and domain databases

InterProiView protein in InterPro
IPR014775 L27_C
IPR004172 L27_dom
IPR036892 L27_dom_sf
IPR017365 LIN7
IPR001478 PDZ
IPR036034 PDZ_sf
PfamiView protein in Pfam
PF02828 L27, 1 hit
PF00595 PDZ, 1 hit
PIRSFiPIRSF038039 Lin-7_homologue, 1 hit
SMARTiView protein in SMART
SM00569 L27, 1 hit
SM00228 PDZ, 1 hit
SUPFAMiSSF101288 SSF101288, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS51022 L27, 1 hit
PS50106 PDZ, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLIN7A_HUMAN
AccessioniPrimary (citable) accession number: O14910
Secondary accession number(s): A4FTY3
, Q147W1, Q6LES3, Q7LDS4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: May 1, 1999
Last modified: November 7, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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