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Entry version 177 (16 Oct 2019)
Sequence version 2 (01 Aug 1999)
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Protein

PDZ domain-containing protein GIPC1

Gene

GIPC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in G protein-linked signaling.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
O14908

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PDZ domain-containing protein GIPC1
Alternative name(s):
GAIP C-terminus-interacting protein
RGS-GAIP-interacting protein
RGS19-interacting protein 1
Synectin
Tax interaction protein 2
Short name:
TIP-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GIPC1
Synonyms:C19orf3, GIPC, RGS19IP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1226 GIPC1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605072 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O14908

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10755

Open Targets

More...
OpenTargetsi
ENSG00000123159

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34371

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O14908

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GIPC1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000874921 – 333PDZ domain-containing protein GIPC1Add BLAST333

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei68PhosphoserineCombined sources1
Modified residuei222PhosphoserineCombined sources1
Modified residuei225PhosphoserineCombined sources1
Modified residuei232PhosphoserineCombined sources1
Modified residuei242PhosphothreonineCombined sources1
Modified residuei247PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O14908

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O14908

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O14908

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O14908

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O14908

PeptideAtlas

More...
PeptideAtlasi
O14908

PRoteomics IDEntifications database

More...
PRIDEi
O14908

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
1863
48292 [O14908-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O14908

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O14908

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000123159 Expressed in 236 organ(s), highest expression level in esophagus mucosa

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O14908 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O14908 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043958
HPA061786

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with GLUT1 (C-terminus), ACTN1, KIF1B, MYO6, PLEKHG5, SDC4/syndecan-4 and SEMA4C/semaphorin-4C (By similarity).

Interacts with RGS19 C-terminus.

Interacts with HTLV-I Tax through the PDZ domain.

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115978, 69 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
O14908

Database of interacting proteins

More...
DIPi
DIP-31142N

Protein interaction database and analysis system

More...
IntActi
O14908, 19 interactors

Molecular INTeraction database

More...
MINTi
O14908

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000376753

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O14908

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini133 – 213PDZPROSITE-ProRule annotationAdd BLAST81

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi36 – 42Poly-Gly7
Compositional biasi48 – 52Poly-Pro5

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GIPC family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3938 Eukaryota
ENOG410XQ87 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003420

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000293347

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O14908

KEGG Orthology (KO)

More...
KOi
K20056

Identification of Orthologs from Complete Genome Data

More...
OMAi
QIEPQFD

Database of Orthologous Groups

More...
OrthoDBi
1442796at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O14908

TreeFam database of animal gene trees

More...
TreeFami
TF313878

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017379 GIPC1/2/3
IPR001478 PDZ
IPR036034 PDZ_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12259 PTHR12259, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00595 PDZ, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF038083 UCP038083_GIPC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228 PDZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50156 SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50106 PDZ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O14908-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPLGLGRRKK APPLVENEEA EPGRGGLGVG EPGPLGGGGS GGPQMGLPPP
60 70 80 90 100
PPALRPRLVF HTQLAHGSPT GRIEGFTNVK ELYGKIAEAF RLPTAEVMFC
110 120 130 140 150
TLNTHKVDMD KLLGGQIGLE DFIFAHVKGQ RKEVEVFKSE DALGLTITDN
160 170 180 190 200
GAGYAFIKRI KEGSVIDHIH LISVGDMIEA INGQSLLGCR HYEVARLLKE
210 220 230 240 250
LPRGRTFTLK LTEPRKAFDM ISQRSAGGRP GSGPQLGTGR GTLRLRSRGP
260 270 280 290 300
ATVEDLPSAF EEKAIEKVDD LLESYMGIRD TELAATMVEL GKDKRNPDEL
310 320 330
AEALDERLGD FAFPDEFVFD VWGAIGDAKV GRY
Length:333
Mass (Da):36,049
Last modified:August 1, 1999 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAA980A4B907E3FD9
GO
Isoform 2 (identifier: O14908-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: Missing.

Show »
Length:236
Mass (Da):26,072
Checksum:iD1DEC176B95C53B1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ESN1K7ESN1_HUMAN
PDZ domain-containing protein GIPC1
GIPC1
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EM11K7EM11_HUMAN
PDZ domain-containing protein GIPC1
GIPC1
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ELJ2K7ELJ2_HUMAN
PDZ domain-containing protein GIPC1
GIPC1
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EIT0K7EIT0_HUMAN
PDZ domain-containing protein GIPC1
GIPC1
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJ33K7EJ33_HUMAN
PDZ domain-containing protein GIPC1
GIPC1
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0442961 – 97Missing in isoform 2. 1 PublicationAdd BLAST97

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF089816 mRNA Translation: AAC67548.1
AK290948 mRNA Translation: BAF83637.1
AC008569 Genomic DNA No translation available.
AC012318 Genomic DNA No translation available.
CH471106 Genomic DNA Translation: EAW84423.1
CH471106 Genomic DNA Translation: EAW84425.1
BC000410 mRNA Translation: AAH00410.1
BC004226 mRNA Translation: AAH04226.2
BC012810 mRNA Translation: AAH12810.1
BC016169 mRNA Translation: AAH16169.1
AF028824 mRNA Translation: AAB84249.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12310.1 [O14908-1]
CCDS12311.1 [O14908-2]

NCBI Reference Sequences

More...
RefSeqi
NP_005707.1, NM_005716.3 [O14908-1]
NP_974197.1, NM_202468.2 [O14908-1]
NP_974198.1, NM_202469.2 [O14908-2]
NP_974199.1, NM_202470.2 [O14908-1]
NP_974223.1, NM_202494.2 [O14908-2]
XP_016881636.1, XM_017026147.1 [O14908-1]
XP_016881637.1, XM_017026148.1 [O14908-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000345425; ENSP00000340698; ENSG00000123159 [O14908-1]
ENST00000393028; ENSP00000376748; ENSG00000123159 [O14908-2]
ENST00000393033; ENSP00000376753; ENSG00000123159 [O14908-1]
ENST00000586027; ENSP00000466747; ENSG00000123159 [O14908-1]
ENST00000591349; ENSP00000467077; ENSG00000123159 [O14908-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10755

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10755

UCSC genome browser

More...
UCSCi
uc002myt.5 human [O14908-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF089816 mRNA Translation: AAC67548.1
AK290948 mRNA Translation: BAF83637.1
AC008569 Genomic DNA No translation available.
AC012318 Genomic DNA No translation available.
CH471106 Genomic DNA Translation: EAW84423.1
CH471106 Genomic DNA Translation: EAW84425.1
BC000410 mRNA Translation: AAH00410.1
BC004226 mRNA Translation: AAH04226.2
BC012810 mRNA Translation: AAH12810.1
BC016169 mRNA Translation: AAH16169.1
AF028824 mRNA Translation: AAB84249.1
CCDSiCCDS12310.1 [O14908-1]
CCDS12311.1 [O14908-2]
RefSeqiNP_005707.1, NM_005716.3 [O14908-1]
NP_974197.1, NM_202468.2 [O14908-1]
NP_974198.1, NM_202469.2 [O14908-2]
NP_974199.1, NM_202470.2 [O14908-1]
NP_974223.1, NM_202494.2 [O14908-2]
XP_016881636.1, XM_017026147.1 [O14908-1]
XP_016881637.1, XM_017026148.1 [O14908-2]

3D structure databases

SMRiO14908
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115978, 69 interactors
CORUMiO14908
DIPiDIP-31142N
IntActiO14908, 19 interactors
MINTiO14908
STRINGi9606.ENSP00000376753

PTM databases

iPTMnetiO14908
PhosphoSitePlusiO14908

Polymorphism and mutation databases

BioMutaiGIPC1

Proteomic databases

EPDiO14908
jPOSTiO14908
MassIVEiO14908
MaxQBiO14908
PaxDbiO14908
PeptideAtlasiO14908
PRIDEiO14908
ProteomicsDBi1863
48292 [O14908-1]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
10755

Genome annotation databases

EnsembliENST00000345425; ENSP00000340698; ENSG00000123159 [O14908-1]
ENST00000393028; ENSP00000376748; ENSG00000123159 [O14908-2]
ENST00000393033; ENSP00000376753; ENSG00000123159 [O14908-1]
ENST00000586027; ENSP00000466747; ENSG00000123159 [O14908-1]
ENST00000591349; ENSP00000467077; ENSG00000123159 [O14908-2]
GeneIDi10755
KEGGihsa:10755
UCSCiuc002myt.5 human [O14908-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10755
DisGeNETi10755

GeneCards: human genes, protein and diseases

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GeneCardsi
GIPC1
HGNCiHGNC:1226 GIPC1
HPAiHPA043958
HPA061786
MIMi605072 gene
neXtProtiNX_O14908
OpenTargetsiENSG00000123159
PharmGKBiPA34371

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3938 Eukaryota
ENOG410XQ87 LUCA
GeneTreeiENSGT00390000003420
HOGENOMiHOG000293347
InParanoidiO14908
KOiK20056
OMAiQIEPQFD
OrthoDBi1442796at2759
PhylomeDBiO14908
TreeFamiTF313878

Enzyme and pathway databases

SignaLinkiO14908

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GIPC1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
GIPC1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10755
PharosiO14908

Protein Ontology

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PROi
PR:O14908

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000123159 Expressed in 236 organ(s), highest expression level in esophagus mucosa
ExpressionAtlasiO14908 baseline and differential
GenevisibleiO14908 HS

Family and domain databases

InterProiView protein in InterPro
IPR017379 GIPC1/2/3
IPR001478 PDZ
IPR036034 PDZ_sf
PANTHERiPTHR12259 PTHR12259, 1 hit
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
PIRSFiPIRSF038083 UCP038083_GIPC, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGIPC1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O14908
Secondary accession number(s): A8K4I3, A8MZG3, Q9BTC9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: August 1, 1999
Last modified: October 16, 2019
This is version 177 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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