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Protein

PDZ domain-containing protein GIPC1

Gene

GIPC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in G protein-linked signaling.

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

SignaLinkiO14908

Names & Taxonomyi

Protein namesi
Recommended name:
PDZ domain-containing protein GIPC1
Alternative name(s):
GAIP C-terminus-interacting protein
RGS-GAIP-interacting protein
RGS19-interacting protein 1
Synectin
Tax interaction protein 2
Short name:
TIP-2
Gene namesi
Name:GIPC1
Synonyms:C19orf3, GIPC, RGS19IP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000123159.15
HGNCiHGNC:1226 GIPC1
MIMi605072 gene
neXtProtiNX_O14908

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10755
OpenTargetsiENSG00000123159
PharmGKBiPA34371

Polymorphism and mutation databases

BioMutaiGIPC1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000874921 – 333PDZ domain-containing protein GIPC1Add BLAST333

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei68PhosphoserineCombined sources1
Modified residuei222PhosphoserineCombined sources1
Modified residuei225PhosphoserineCombined sources1
Modified residuei232PhosphoserineCombined sources1
Modified residuei242PhosphothreonineCombined sources1
Modified residuei247PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO14908
MaxQBiO14908
PaxDbiO14908
PeptideAtlasiO14908
PRIDEiO14908
ProteomicsDBi48292

PTM databases

iPTMnetiO14908
PhosphoSitePlusiO14908

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSG00000123159 Expressed in 236 organ(s), highest expression level in esophagus mucosa
CleanExiHS_GIPC1
ExpressionAtlasiO14908 baseline and differential
GenevisibleiO14908 HS

Organism-specific databases

HPAiHPA043958
HPA061786

Interactioni

Subunit structurei

Interacts with GLUT1 (C-terminus), ACTN1, KIF1B, MYO6, PLEKHG5, SDC4/syndecan-4 and SEMA4C/semaphorin-4C (By similarity). Interacts with RGS19 C-terminus. Interacts with HTLV-I Tax through the PDZ domain.By similarity2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115978, 41 interactors
CORUMiO14908
DIPiDIP-31142N
IntActiO14908, 18 interactors
MINTiO14908
STRINGi9606.ENSP00000340698

Structurei

3D structure databases

ProteinModelPortaliO14908
SMRiO14908
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini133 – 213PDZPROSITE-ProRule annotationAdd BLAST81

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi36 – 42Poly-Gly7
Compositional biasi48 – 52Poly-Pro5

Sequence similaritiesi

Belongs to the GIPC family.Curated

Phylogenomic databases

eggNOGiKOG3938 Eukaryota
ENOG410XQ87 LUCA
GeneTreeiENSGT00390000003420
HOGENOMiHOG000293347
HOVERGENiHBG000898
InParanoidiO14908
KOiK20056
OMAiMIESING
OrthoDBiEOG091G0D3X
PhylomeDBiO14908
TreeFamiTF313878

Family and domain databases

InterProiView protein in InterPro
IPR017379 GIPC1/2/3
IPR001478 PDZ
IPR036034 PDZ_sf
PANTHERiPTHR12259 PTHR12259, 1 hit
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
PIRSFiPIRSF038083 UCP038083_GIPC, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O14908-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPLGLGRRKK APPLVENEEA EPGRGGLGVG EPGPLGGGGS GGPQMGLPPP
60 70 80 90 100
PPALRPRLVF HTQLAHGSPT GRIEGFTNVK ELYGKIAEAF RLPTAEVMFC
110 120 130 140 150
TLNTHKVDMD KLLGGQIGLE DFIFAHVKGQ RKEVEVFKSE DALGLTITDN
160 170 180 190 200
GAGYAFIKRI KEGSVIDHIH LISVGDMIEA INGQSLLGCR HYEVARLLKE
210 220 230 240 250
LPRGRTFTLK LTEPRKAFDM ISQRSAGGRP GSGPQLGTGR GTLRLRSRGP
260 270 280 290 300
ATVEDLPSAF EEKAIEKVDD LLESYMGIRD TELAATMVEL GKDKRNPDEL
310 320 330
AEALDERLGD FAFPDEFVFD VWGAIGDAKV GRY
Length:333
Mass (Da):36,049
Last modified:August 1, 1999 - v2
Checksum:iAA980A4B907E3FD9
GO
Isoform 2 (identifier: O14908-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: Missing.

Show »
Length:236
Mass (Da):26,072
Checksum:iD1DEC176B95C53B1
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EIT0K7EIT0_HUMAN
PDZ domain-containing protein GIPC1
GIPC1
121Annotation score:
K7ESN1K7ESN1_HUMAN
PDZ domain-containing protein GIPC1
GIPC1
159Annotation score:
K7EJ33K7EJ33_HUMAN
PDZ domain-containing protein GIPC1
GIPC1
62Annotation score:
K7EM11K7EM11_HUMAN
PDZ domain-containing protein GIPC1
GIPC1
128Annotation score:
K7ELJ2K7ELJ2_HUMAN
PDZ domain-containing protein GIPC1
GIPC1
40Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0442961 – 97Missing in isoform 2. 1 PublicationAdd BLAST97

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF089816 mRNA Translation: AAC67548.1
AK290948 mRNA Translation: BAF83637.1
AC008569 Genomic DNA No translation available.
AC012318 Genomic DNA No translation available.
CH471106 Genomic DNA Translation: EAW84423.1
CH471106 Genomic DNA Translation: EAW84425.1
BC000410 mRNA Translation: AAH00410.1
BC004226 mRNA Translation: AAH04226.2
BC012810 mRNA Translation: AAH12810.1
BC016169 mRNA Translation: AAH16169.1
AF028824 mRNA Translation: AAB84249.1
CCDSiCCDS12310.1 [O14908-1]
CCDS12311.1 [O14908-2]
RefSeqiNP_005707.1, NM_005716.3 [O14908-1]
NP_974197.1, NM_202468.2 [O14908-1]
NP_974198.1, NM_202469.2 [O14908-2]
NP_974199.1, NM_202470.2 [O14908-1]
NP_974223.1, NM_202494.2 [O14908-2]
XP_016881636.1, XM_017026147.1 [O14908-1]
XP_016881637.1, XM_017026148.1 [O14908-2]
UniGeneiHs.655012
Hs.741240

Genome annotation databases

EnsembliENST00000345425; ENSP00000340698; ENSG00000123159 [O14908-1]
ENST00000393028; ENSP00000376748; ENSG00000123159 [O14908-2]
ENST00000393033; ENSP00000376753; ENSG00000123159 [O14908-1]
ENST00000586027; ENSP00000466747; ENSG00000123159 [O14908-1]
ENST00000591349; ENSP00000467077; ENSG00000123159 [O14908-2]
GeneIDi10755
KEGGihsa:10755
UCSCiuc002myt.5 human [O14908-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF089816 mRNA Translation: AAC67548.1
AK290948 mRNA Translation: BAF83637.1
AC008569 Genomic DNA No translation available.
AC012318 Genomic DNA No translation available.
CH471106 Genomic DNA Translation: EAW84423.1
CH471106 Genomic DNA Translation: EAW84425.1
BC000410 mRNA Translation: AAH00410.1
BC004226 mRNA Translation: AAH04226.2
BC012810 mRNA Translation: AAH12810.1
BC016169 mRNA Translation: AAH16169.1
AF028824 mRNA Translation: AAB84249.1
CCDSiCCDS12310.1 [O14908-1]
CCDS12311.1 [O14908-2]
RefSeqiNP_005707.1, NM_005716.3 [O14908-1]
NP_974197.1, NM_202468.2 [O14908-1]
NP_974198.1, NM_202469.2 [O14908-2]
NP_974199.1, NM_202470.2 [O14908-1]
NP_974223.1, NM_202494.2 [O14908-2]
XP_016881636.1, XM_017026147.1 [O14908-1]
XP_016881637.1, XM_017026148.1 [O14908-2]
UniGeneiHs.655012
Hs.741240

3D structure databases

ProteinModelPortaliO14908
SMRiO14908
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115978, 41 interactors
CORUMiO14908
DIPiDIP-31142N
IntActiO14908, 18 interactors
MINTiO14908
STRINGi9606.ENSP00000340698

PTM databases

iPTMnetiO14908
PhosphoSitePlusiO14908

Polymorphism and mutation databases

BioMutaiGIPC1

Proteomic databases

EPDiO14908
MaxQBiO14908
PaxDbiO14908
PeptideAtlasiO14908
PRIDEiO14908
ProteomicsDBi48292

Protocols and materials databases

DNASUi10755
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000345425; ENSP00000340698; ENSG00000123159 [O14908-1]
ENST00000393028; ENSP00000376748; ENSG00000123159 [O14908-2]
ENST00000393033; ENSP00000376753; ENSG00000123159 [O14908-1]
ENST00000586027; ENSP00000466747; ENSG00000123159 [O14908-1]
ENST00000591349; ENSP00000467077; ENSG00000123159 [O14908-2]
GeneIDi10755
KEGGihsa:10755
UCSCiuc002myt.5 human [O14908-1]

Organism-specific databases

CTDi10755
DisGeNETi10755
EuPathDBiHostDB:ENSG00000123159.15
GeneCardsiGIPC1
HGNCiHGNC:1226 GIPC1
HPAiHPA043958
HPA061786
MIMi605072 gene
neXtProtiNX_O14908
OpenTargetsiENSG00000123159
PharmGKBiPA34371
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3938 Eukaryota
ENOG410XQ87 LUCA
GeneTreeiENSGT00390000003420
HOGENOMiHOG000293347
HOVERGENiHBG000898
InParanoidiO14908
KOiK20056
OMAiMIESING
OrthoDBiEOG091G0D3X
PhylomeDBiO14908
TreeFamiTF313878

Enzyme and pathway databases

SignaLinkiO14908

Miscellaneous databases

ChiTaRSiGIPC1 human
GeneWikiiGIPC1
GenomeRNAii10755
PROiPR:O14908
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000123159 Expressed in 236 organ(s), highest expression level in esophagus mucosa
CleanExiHS_GIPC1
ExpressionAtlasiO14908 baseline and differential
GenevisibleiO14908 HS

Family and domain databases

InterProiView protein in InterPro
IPR017379 GIPC1/2/3
IPR001478 PDZ
IPR036034 PDZ_sf
PANTHERiPTHR12259 PTHR12259, 1 hit
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
PIRSFiPIRSF038083 UCP038083_GIPC, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGIPC1_HUMAN
AccessioniPrimary (citable) accession number: O14908
Secondary accession number(s): A8K4I3, A8MZG3, Q9BTC9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: August 1, 1999
Last modified: October 10, 2018
This is version 168 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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