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Protein

Tax1-binding protein 3

Gene

TAX1BP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6.3 Publications

GO - Molecular functioni

  • beta-catenin binding Source: Ensembl
  • protein C-terminus binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processWnt signaling pathway

Enzyme and pathway databases

BRENDAi3.5.1.2 2681
ReactomeiR-HSA-5666185 RHO GTPases Activate Rhotekin and Rhophilins

Names & Taxonomyi

Protein namesi
Recommended name:
Tax1-binding protein 3
Alternative name(s):
Glutaminase-interacting protein 3
Tax interaction protein 1
Short name:
TIP-1
Tax-interacting protein 1
Gene namesi
Name:TAX1BP3Imported
Synonyms:TIP1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000213977.7
HGNCiHGNC:30684 TAX1BP3
MIMi616476 gene
neXtProtiNX_O14907

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi20K → A: Abolishes interaction with KCNJ4. 1 Publication1
Mutagenesisi90H → A: Abolishes interaction with KCNJ4. 1 Publication1

Organism-specific databases

DisGeNETi30851
OpenTargetsiENSG00000213977
PharmGKBiPA134950693

Polymorphism and mutation databases

BioMutaiTAX1BP3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002339432 – 124Tax1-binding protein 3Add BLAST123

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei61PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO14907
MaxQBiO14907
PaxDbiO14907
PeptideAtlasiO14907
PRIDEiO14907
ProteomicsDBi48291
TopDownProteomicsiO14907

2D gel databases

UCD-2DPAGEiO14907

PTM databases

iPTMnetiO14907
PhosphoSitePlusiO14907

Expressioni

Tissue specificityi

Ubiquitous. Detected in brain, heart, kidney, lung, small intestine and skeletal muscle. Detected in various cell lines including HeLa. Weakly expressed in peripheral blood leukocytes.3 Publications

Gene expression databases

BgeeiENSG00000213977 Expressed in 90 organ(s), highest expression level in tibial nerve
CleanExiHS_TAX1BP3
ExpressionAtlasiO14907 baseline and differential
GenevisibleiO14907 HS

Organism-specific databases

HPAiHPA046410
HPA063078

Interactioni

Subunit structurei

Interacts (via its PDZ domain) with GLS2. Interacts (via its PDZ domain) with RTKN (via the C-terminal region); this interaction facilitates Rho-mediated activation of the FOS serum response element (SRE). Interacts (via its PDZ domain) with CTNNB1; this interaction inhibits the transcriptional activity of CTNNB1. Interacts with HTLV-1 TAX protein. Interacts (via PDZ domain) with ARHGEF16. Interacts (via PDZ domain) with KCNJ4 (via C-terminus). Competes with LIN7A for KCNJ4 binding. Interacts with ADGRB2 (PubMed:21787750).9 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119061, 45 interactors
ELMiO14907
IntActiO14907, 16 interactors
MINTiO14907
STRINGi9606.ENSP00000225525

Structurei

Secondary structure

1124
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO14907
SMRiO14907
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO14907

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 112PDZPROSITE-ProRule annotationAdd BLAST98

Phylogenomic databases

eggNOGiKOG3553 Eukaryota
ENOG4111IK0 LUCA
GeneTreeiENSGT00390000002877
HOGENOMiHOG000015753
HOVERGENiHBG052814
InParanoidiO14907
OMAiHKETEIN
OrthoDBiEOG091G0UZR
PhylomeDBiO14907
TreeFamiTF318964

Family and domain databases

InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
IPR017268 Tax1-binding_p3
PANTHERiPTHR23136 PTHR23136, 1 hit
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
PIRSFiPIRSF037712 Tax1-binding_p3, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

O14907-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSYIPGQPVT AVVQRVEIHK LRQGENLILG FSIGGGIDQD PSQNPFSEDK
60 70 80 90 100
TDKGIYVTRV SEGGPAEIAG LQIGDKIMQV NGWDMTMVTH DQARKRLTKR
110 120
SEEVVRLLVT RQSLQKAVQQ SMLS
Length:124
Mass (Da):13,735
Last modified:March 1, 2001 - v2
Checksum:iFF0BCDF475F682CD
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X282A0A087X282_HUMAN
Tax1-binding protein 3
TAX1BP3
98Annotation score:

Sequence cautioni

The sequence AAF43104 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07396633I → T Found in a patient with dilated cardiomyopathy and septo-optic dysplasia; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1057517690Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF028823 mRNA Translation: AAB84248.2
AF168787 Genomic DNA Translation: AAF43104.1 Different initiation.
AF234997 mRNA Translation: AAG44368.1
AF277318 mRNA Translation: AAK69111.1
AK315408 mRNA Translation: BAG37800.1
CH471108 Genomic DNA Translation: EAW90491.1
CH471108 Genomic DNA Translation: EAW90492.1
BC023980 mRNA Translation: AAH23980.1
CCDSiCCDS11032.1
RefSeqiNP_001191627.1, NM_001204698.1
NP_055419.1, NM_014604.3
UniGeneiHs.12956
Hs.731607

Genome annotation databases

EnsembliENST00000225525; ENSP00000225525; ENSG00000213977
GeneIDi30851
KEGGihsa:30851
UCSCiuc002fwc.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF028823 mRNA Translation: AAB84248.2
AF168787 Genomic DNA Translation: AAF43104.1 Different initiation.
AF234997 mRNA Translation: AAG44368.1
AF277318 mRNA Translation: AAK69111.1
AK315408 mRNA Translation: BAG37800.1
CH471108 Genomic DNA Translation: EAW90491.1
CH471108 Genomic DNA Translation: EAW90492.1
BC023980 mRNA Translation: AAH23980.1
CCDSiCCDS11032.1
RefSeqiNP_001191627.1, NM_001204698.1
NP_055419.1, NM_014604.3
UniGeneiHs.12956
Hs.731607

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KG2NMR-A2-124[»]
2L4SNMR-A1-124[»]
2L4TNMR-A1-124[»]
2VZ5X-ray1.74A13-113[»]
3GJ9X-ray2.80A/B1-124[»]
3SFJX-ray1.24A/C10-112[»]
4E3BX-ray1.50A/B11-112[»]
4NNLX-ray1.50A/B10-112[»]
4NNMX-ray1.60A/B10-120[»]
ProteinModelPortaliO14907
SMRiO14907
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119061, 45 interactors
ELMiO14907
IntActiO14907, 16 interactors
MINTiO14907
STRINGi9606.ENSP00000225525

PTM databases

iPTMnetiO14907
PhosphoSitePlusiO14907

Polymorphism and mutation databases

BioMutaiTAX1BP3

2D gel databases

UCD-2DPAGEiO14907

Proteomic databases

EPDiO14907
MaxQBiO14907
PaxDbiO14907
PeptideAtlasiO14907
PRIDEiO14907
ProteomicsDBi48291
TopDownProteomicsiO14907

Protocols and materials databases

DNASUi30851
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000225525; ENSP00000225525; ENSG00000213977
GeneIDi30851
KEGGihsa:30851
UCSCiuc002fwc.4 human

Organism-specific databases

CTDi30851
DisGeNETi30851
EuPathDBiHostDB:ENSG00000213977.7
GeneCardsiTAX1BP3
HGNCiHGNC:30684 TAX1BP3
HPAiHPA046410
HPA063078
MIMi616476 gene
neXtProtiNX_O14907
OpenTargetsiENSG00000213977
PharmGKBiPA134950693
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3553 Eukaryota
ENOG4111IK0 LUCA
GeneTreeiENSGT00390000002877
HOGENOMiHOG000015753
HOVERGENiHBG052814
InParanoidiO14907
OMAiHKETEIN
OrthoDBiEOG091G0UZR
PhylomeDBiO14907
TreeFamiTF318964

Enzyme and pathway databases

BRENDAi3.5.1.2 2681
ReactomeiR-HSA-5666185 RHO GTPases Activate Rhotekin and Rhophilins

Miscellaneous databases

ChiTaRSiTAX1BP3 human
EvolutionaryTraceiO14907
GeneWikiiTAX1BP3
GenomeRNAii30851
PROiPR:O14907
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000213977 Expressed in 90 organ(s), highest expression level in tibial nerve
CleanExiHS_TAX1BP3
ExpressionAtlasiO14907 baseline and differential
GenevisibleiO14907 HS

Family and domain databases

InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
IPR017268 Tax1-binding_p3
PANTHERiPTHR23136 PTHR23136, 1 hit
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
PIRSFiPIRSF037712 Tax1-binding_p3, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTX1B3_HUMAN
AccessioniPrimary (citable) accession number: O14907
Secondary accession number(s): B2RD53, D3DTJ6, Q7LCQ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: March 1, 2001
Last modified: September 12, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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