Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein Wnt-9b

Gene

WNT9B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors (PubMed:20093360). Functions in the canonical Wnt/beta-catenin signaling pathway. Plays a role in cranofacial development and is required for normal fusion of the palate during embryonic development (By similarity).By similarity1 Publication

GO - Molecular functioni

  • co-receptor binding Source: Ensembl
  • frizzled binding Source: GO_Central
  • receptor ligand activity Source: WormBase

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-HSA-3238698 WNT ligand biogenesis and trafficking
R-HSA-373080 Class B/2 (Secretin family receptors)
SIGNORiO14905

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-9b
Alternative name(s):
Protein Wnt-14b
Protein Wnt-15
Gene namesi
Name:WNT9B
Synonyms:WNT14B1 Publication, WNT15
ORF Names:UNQ6973/PRO21956
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000158955.10
HGNCiHGNC:12779 WNT9B
MIMi602864 gene
neXtProtiNX_O14905

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi7484
OpenTargetsiENSG00000158955
PharmGKBiPA37380

Polymorphism and mutation databases

BioMutaiWNT9B

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000004145823 – 357Protein Wnt-9bAdd BLAST335

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi89 ↔ 100By similarity
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi135 ↔ 143By similarity
Disulfide bondi145 ↔ 162By similarity
Disulfide bondi210 ↔ 224By similarity
Disulfide bondi212 ↔ 219By similarity
Lipidationi216O-palmitoleoyl serine; by PORCNBy similarity1
Disulfide bondi305 ↔ 316By similarity
Disulfide bondi331 ↔ 346By similarity
Disulfide bondi333 ↔ 343By similarity
Disulfide bondi338 ↔ 339By similarity

Post-translational modificationi

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

PaxDbiO14905
PeptideAtlasiO14905
PRIDEiO14905
ProteomicsDBi48290

PTM databases

iPTMnetiO14905
PhosphoSitePlusiO14905

Expressioni

Tissue specificityi

Moderately expressed in fetal kidney and adult kidney. Also found in brain.

Gene expression databases

BgeeiENSG00000158955
CleanExiHS_WNT9B
ExpressionAtlasiO14905 baseline and differential
GenevisibleiO14905 HS

Organism-specific databases

HPAiHPA058361
HPA059572

Interactioni

Subunit structurei

Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity (PubMed:26902720). The complex with AFM may represent the physiological form in body fluids (PubMed:26902720). Component of the Wnt-Fzd-LRP5-LRP6 signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts directly in the complex with LRP6 (PubMed:20093360).2 Publications

GO - Molecular functioni

  • co-receptor binding Source: Ensembl
  • frizzled binding Source: GO_Central
  • receptor ligand activity Source: WormBase

Protein-protein interaction databases

BioGridi113321, 5 interactors
STRINGi9606.ENSP00000290015

Structurei

3D structure databases

ProteinModelPortaliO14905
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3913 Eukaryota
ENOG410XQZ1 LUCA
GeneTreeiENSGT00690000101857
HOGENOMiHOG000039529
HOVERGENiHBG001595
InParanoidiO14905
KOiK01064
OMAiCAKDTSC
OrthoDBiEOG091G0OFF
PhylomeDBiO14905
TreeFamiTF105310

Family and domain databases

InterProiView protein in InterPro
IPR005817 Wnt
IPR026535 WNT9B
IPR018161 Wnt_CS
PANTHERiPTHR12027 PTHR12027, 1 hit
PTHR12027:SF84 PTHR12027:SF84, 1 hit
PfamiView protein in Pfam
PF00110 wnt, 1 hit
PRINTSiPR01349 WNTPROTEIN
SMARTiView protein in SMART
SM00097 WNT1, 1 hit
PROSITEiView protein in PROSITE
PS00246 WNT1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O14905-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPPPALALA GLCLLALPAA AASYFGLTGR EVLTPFPGLG TAAAPAQGGA
60 70 80 90 100
HLKQCDLLKL SRRQKQLCRR EPGLAETLRD AAHLGLLECQ FQFRHERWNC
110 120 130 140 150
SLEGRMGLLK RGFKETAFLY AVSSAALTHT LARACSAGRM ERCTCDDSPG
160 170 180 190 200
LESRQAWQWG VCGDNLKYST KFLSNFLGSK RGNKDLRARA DAHNTHVGIK
210 220 230 240 250
AVKSGLRTTC KCHGVSGSCA VRTCWKQLSP FRETGQVLKL RYDSAVKVSS
260 270 280 290 300
ATNEALGRLE LWAPARQGSL TKGLAPRSGD LVYMEDSPSF CRPSKYSPGT
310 320 330 340 350
AGRVCSREAS CSSLCCGRGY DTQSRLVAFS CHCQVQWCCY VECQQCVQEE

LVYTCKH
Length:357
Mass (Da):39,001
Last modified:November 30, 2010 - v3
Checksum:iCC22162F9D294CB8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030839106M → T1 PublicationCorresponds to variant dbSNP:rs4968281Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB063483 mRNA Translation: BAB70499.1
AY358217 mRNA Translation: AAQ88584.1
AC015855 Genomic DNA No translation available.
AF028703 Genomic DNA Translation: AAC39551.1
CCDSiCCDS11506.1
RefSeqiNP_003387.1, NM_003396.2
UniGeneiHs.326420

Genome annotation databases

EnsembliENST00000290015; ENSP00000290015; ENSG00000158955
ENST00000613753; ENSP00000482127; ENSG00000276799
GeneIDi7484
KEGGihsa:7484
UCSCiuc002ikw.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiWNT9B_HUMAN
AccessioniPrimary (citable) accession number: O14905
Secondary accession number(s): Q6UXT4, Q96Q09
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 30, 2010
Last modified: June 20, 2018
This is version 141 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health