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Protein

Protein Wnt-9a

Gene

WNT9A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Plays a redundant role in maintaining joint integrity.By similarity

GO - Molecular functioni

  • frizzled binding Source: GO_Central
  • receptor ligand activity Source: WormBase

GO - Biological processi

  • canonical Wnt signaling pathway Source: WormBase
  • cell-cell signaling Source: UniProtKB
  • cell fate commitment Source: GO_Central
  • cellular response to retinoic acid Source: UniProtKB
  • cornea development in camera-type eye Source: BHF-UCL
  • embryonic forelimb morphogenesis Source: Ensembl
  • embryonic skeletal joint development Source: BHF-UCL
  • embryonic skeletal system morphogenesis Source: Ensembl
  • iris morphogenesis Source: BHF-UCL
  • mitotic cell cycle checkpoint Source: BHF-UCL
  • multicellular organism development Source: UniProtKB
  • negative regulation of cell proliferation Source: BHF-UCL
  • negative regulation of chondrocyte differentiation Source: BHF-UCL
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  • neuron differentiation Source: UniProtKB
  • positive regulation of cell differentiation Source: Ensembl
  • positive regulation of smoothened signaling pathway Source: Ensembl
  • Wnt signaling pathway Source: GO_Central

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-3238698 WNT ligand biogenesis and trafficking
R-HSA-373080 Class B/2 (Secretin family receptors)
R-HSA-3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists
SIGNORiO14904

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-9a
Alternative name(s):
Protein Wnt-14
Gene namesi
Name:WNT9A
Synonyms:WNT14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143816.7
HGNCiHGNC:12778 WNT9A
MIMi602863 gene
neXtProtiNX_O14904

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi7483
OpenTargetsiENSG00000143816
PharmGKBiPA37379

Polymorphism and mutation databases

BioMutaiWNT9A

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000004145530 – 365Protein Wnt-9aAdd BLAST336

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi93 ↔ 104By similarity
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi141 ↔ 149By similarity
Disulfide bondi151 ↔ 168By similarity
Disulfide bondi215 ↔ 229By similarity
Disulfide bondi217 ↔ 224By similarity
Lipidationi221O-palmitoleoyl serine; by PORCNBy similarity1
Disulfide bondi313 ↔ 324By similarity
Disulfide bondi339 ↔ 354By similarity
Disulfide bondi341 ↔ 351By similarity
Disulfide bondi346 ↔ 347By similarity

Post-translational modificationi

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

PaxDbiO14904
PeptideAtlasiO14904
PRIDEiO14904
ProteomicsDBi48289

PTM databases

PhosphoSitePlusiO14904

Expressioni

Gene expression databases

BgeeiENSG00000143816
CleanExiHS_WNT9A
ExpressionAtlasiO14904 baseline and differential
GenevisibleiO14904 HS

Interactioni

Subunit structurei

Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity (PubMed:26902720). The complex with AFM may represent the physiological form in body fluids (PubMed:26902720).1 Publication

GO - Molecular functioni

  • frizzled binding Source: GO_Central
  • receptor ligand activity Source: WormBase

Protein-protein interaction databases

IntActiO14904, 1 interactor
STRINGi9606.ENSP00000272164

Structurei

3D structure databases

ProteinModelPortaliO14904
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3913 Eukaryota
ENOG410XQZ1 LUCA
GeneTreeiENSGT00690000101857
HOGENOMiHOG000039529
HOVERGENiHBG001595
InParanoidiO14904
KOiK01064
OMAiVECKQCT
OrthoDBiEOG091G0OFF
PhylomeDBiO14904
TreeFamiTF105310

Family and domain databases

InterProiView protein in InterPro
IPR005817 Wnt
IPR013303 Wnt9a
IPR018161 Wnt_CS
PANTHERiPTHR12027 PTHR12027, 1 hit
PTHR12027:SF75 PTHR12027:SF75, 1 hit
PfamiView protein in Pfam
PF00110 wnt, 1 hit
PRINTSiPR01894 WNT14PROTEIN
PR01349 WNTPROTEIN
SMARTiView protein in SMART
SM00097 WNT1, 1 hit
PROSITEiView protein in PROSITE
PS00246 WNT1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O14904-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDGSPLARW LAAAFGLTLL LAALRPSAAY FGLTGSEPLT ILPLTLEPEA
60 70 80 90 100
AAQAHYKACD RLKLERKQRR MCRRDPGVAE TLVEAVSMSA LECQFQFRFE
110 120 130 140 150
RWNCTLEGRY RASLLKRGFK ETAFLYAISS AGLTHALAKA CSAGRMERCT
160 170 180 190 200
CDEAPDLENR EAWQWGGCGD NLKYSSKFVK EFLGRRSSKD LRARVDFHNN
210 220 230 240 250
LVGVKVIKAG VETTCKCHGV SGSCTVRTCW RQLAPFHEVG KHLKHKYETA
260 270 280 290 300
LKVGSTTNEA AGEAGAISPP RGRASGAGGS DPLPRTPELV HLDDSPSFCL
310 320 330 340 350
AGRFSPGTAG RRCHREKNCE SICCGRGHNT QSRVVTRPCQ CQVRWCCYVE
360
CRQCTQREEV YTCKG
Length:365
Mass (Da):40,320
Last modified:May 10, 2002 - v2
Checksum:i1E1284D744C6A9B2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052956260A → T. Corresponds to variant dbSNP:rs8192633Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB060283 mRNA Translation: BAB61051.1
AL360269 Genomic DNA No translation available.
CH471098 Genomic DNA Translation: EAW69821.1
BC111960 mRNA Translation: AAI11961.1
BC113431 mRNA Translation: AAI13432.1
AF028702 Genomic DNA Translation: AAC39550.1
CCDSiCCDS31045.1
RefSeqiNP_003386.1, NM_003395.2
UniGeneiHs.149504

Genome annotation databases

EnsembliENST00000272164; ENSP00000272164; ENSG00000143816
GeneIDi7483
KEGGihsa:7483
UCSCiuc001hri.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiWNT9A_HUMAN
AccessioniPrimary (citable) accession number: O14904
Secondary accession number(s): A6NLW2
, Q2M2J3, Q5VWU0, Q96S50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 10, 2002
Last modified: June 20, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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