UniProtKB - O14901 (KLF11_HUMAN)
Protein
Krueppel-like factor 11
Gene
KLF11
Organism
Homo sapiens (Human)
Status
Functioni
Transcription factor (PubMed:9748269, PubMed:10207080). Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth (PubMed:9748269, PubMed:10207080, PubMed:16131492). Represses transcription of SMAD7 which enhances TGF-beta signaling (By similarity). Induces apoptosis (By similarity).By similarity2 Publications
Caution
PubMed:11087666 sequence was originally thought to originate from mouse.Curated
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 394 – 418 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 424 – 448 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 454 – 476 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: ProtInc
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: BHF-UCL
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
- transcription regulatory region sequence-specific DNA binding Source: BHF-UCL
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- cellular response to peptide Source: Ensembl
- negative regulation of cell population proliferation Source: BHF-UCL
- negative regulation of transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of apoptotic process Source: BHF-UCL
- regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of transcription involved in G1/S transition of mitotic cell cycle Source: BHF-UCL
Keywordsi
Molecular function | Activator, DNA-binding, Repressor |
Biological process | Apoptosis, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | O14901 |
SignaLinki | O14901 |
SIGNORi | O14901 |
Names & Taxonomyi
Protein namesi | Recommended name: Krueppel-like factor 11Alternative name(s): Transforming growth factor-beta-inducible early growth response protein 2 Short name: TGFB-inducible early growth response protein 2 Short name: TIEG-2 |
Gene namesi | Name:KLF11 Synonyms:FKLF, TIEG2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11811, KLF11 |
MIMi | 603301, gene |
neXtProti | NX_O14901 |
VEuPathDBi | HostDB:ENSG00000172059.10 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Cytosol
- cytosol Source: HPA
Nucleus
- nuclear body Source: HPA
- nuclear chromatin Source: NTNU_SB
- nucleoplasm Source: HPA
- nucleus Source: ProtInc
Other locations
- focal adhesion Source: HPA
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Maturity-onset diabetes of the young 7 (MODY7)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_031523 | 220 | T → M in MODY7; absent in one family member with diabetes; increased repression activity; no alteration in binding affinity to SIN3A. 1 PublicationCorresponds to variant dbSNP:rs34336420EnsemblClinVar. | 1 | |
Natural variantiVAR_031524 | 347 | A → S in MODY7; increased repression activity; no alteration in binding affinity to SIN3A. 1 PublicationCorresponds to variant dbSNP:rs121912645EnsemblClinVar. | 1 |
Keywords - Diseasei
Diabetes mellitus, Disease variantOrganism-specific databases
DisGeNETi | 8462 |
GeneReviewsi | KLF11 |
MalaCardsi | KLF11 |
MIMi | 606391, phenotype 610508, phenotype |
OpenTargetsi | ENSG00000172059 |
Orphaneti | 552, MODY |
PharmGKBi | PA36518 |
Miscellaneous databases
Pharosi | O14901, Tbio |
Genetic variation databases
BioMutai | KLF11 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047180 | 1 – 512 | Krueppel-like factor 11Add BLAST | 512 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 124 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | O14901 |
MassIVEi | O14901 |
PaxDbi | O14901 |
PeptideAtlasi | O14901 |
PRIDEi | O14901 |
ProteomicsDBi | 48287 [O14901-1] 48288 [O14901-2] |
PTM databases
iPTMneti | O14901 |
PhosphoSitePlusi | O14901 |
Expressioni
Tissue specificityi
Ubiquitous. Higher expression in erythroid cells.1 Publication
Inductioni
By TGFB1.1 Publication
Gene expression databases
Bgeei | ENSG00000172059, Expressed in secondary oocyte and 222 other tissues |
ExpressionAtlasi | O14901, baseline and differential |
Genevisiblei | O14901, HS |
Organism-specific databases
HPAi | ENSG00000172059, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with SIN3A.
1 PublicationBinary interactionsi
O14901
Protein-protein interaction databases
BioGRIDi | 114040, 21 interactors |
ELMi | O14901 |
IntActi | O14901, 238 interactors |
STRINGi | 9606.ENSP00000307023 |
Miscellaneous databases
RNActi | O14901, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the Sp1 C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 394 – 418 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 424 – 448 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 454 – 476 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000155982 |
HOGENOMi | CLU_046370_0_0_1 |
InParanoidi | O14901 |
OMAi | TCKPRPL |
PhylomeDBi | O14901 |
TreeFami | TF315506 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O14901-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MHTPDFAGPD DARAVDIMDI CESILERKRH DSERSTCSIL EQTDMEAVEA
60 70 80 90 100
LVCMSSWGQR SQKGDLLRIR PLTPVSDSGD VTTTVHMDAA TPELPKDFHS
110 120 130 140 150
LSTLCITPPQ SPDLVEPSTR TPVSPQVTDS KACTATDVLQ SSAVVARALS
160 170 180 190 200
GGAERGLLGL EPVPSSPCRA KGTSVIRHTG ESPAACFPTI QTPDCRLSDS
210 220 230 240 250
REGEEQLLGH FETLQDTHLT DSLLSTNLVS CQPCLHKSGG LLLTDKGQQA
260 270 280 290 300
GWPGAVQTCS PKNYENDLPR KTTPLISVSV PAPPVLCQMI PVTGQSSMLP
310 320 330 340 350
AFLKPPPQLS VGTVRPILAQ AAPAPQPVFV GPAVPQGAVM LVLPQGALPP
360 370 380 390 400
PAPCAANVMA AGNTKLLPLA PAPVFITSSQ NCVPQVDFSR RRNYVCSFPG
410 420 430 440 450
CRKTYFKSSH LKAHLRTHTG EKPFNCSWDG CDKKFARSDE LSRHRRTHTG
460 470 480 490 500
EKKFVCPVCD RRFMRSDHLT KHARRHMTTK KIPGWQAEVG KLNRIASAES
510
PGSPLVSMPA SA
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JM94 | C9JM94_HUMAN | Krueppel-like factor 11 | KLF11 | 122 | Annotation score: | ||
E7EX78 | E7EX78_HUMAN | Krueppel-like factor 11 | KLF11 | 163 | Annotation score: | ||
B5MCC4 | B5MCC4_HUMAN | Krueppel-like factor 11 | KLF11 | 127 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 125 | P → S (PubMed:11087666).Curated | 1 | |
Sequence conflicti | 144 – 150 | VVARALS → QWPDSD (PubMed:11087666).Curated | 7 | |
Sequence conflicti | 371 | P → L (PubMed:11087666).Curated | 1 | |
Sequence conflicti | 415 | L → V (PubMed:11087666).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_031522 | 62 | Q → R High frequency in individuals with diabetes mellitus type 2; increased repression activity; increased binding to SIN3A; impairs activation of insulin promoter. 1 PublicationCorresponds to variant dbSNP:rs35927125EnsemblClinVar. | 1 | |
Natural variantiVAR_031523 | 220 | T → M in MODY7; absent in one family member with diabetes; increased repression activity; no alteration in binding affinity to SIN3A. 1 PublicationCorresponds to variant dbSNP:rs34336420EnsemblClinVar. | 1 | |
Natural variantiVAR_031524 | 347 | A → S in MODY7; increased repression activity; no alteration in binding affinity to SIN3A. 1 PublicationCorresponds to variant dbSNP:rs121912645EnsemblClinVar. | 1 | |
Natural variantiVAR_052717 | 378 | S → F. Corresponds to variant dbSNP:rs35476458Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042695 | 1 – 17 | Missing in isoform 2. 1 PublicationAdd BLAST | 17 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF028008 mRNA Translation: AAC61880.1 AF272830 mRNA Translation: AAF75793.1 AK302880 mRNA Translation: BAG64059.1 AC104794 Genomic DNA No translation available. CH471053 Genomic DNA Translation: EAX00972.1 BC063286 mRNA Translation: AAH63286.1 BC069383 mRNA Translation: AAH69383.1 BC074922 mRNA Translation: AAH74922.1 |
CCDSi | CCDS1668.1 [O14901-1] CCDS54333.1 [O14901-2] |
RefSeqi | NP_001171187.1, NM_001177716.1 [O14901-2] NP_001171189.1, NM_001177718.1 [O14901-2] NP_003588.1, NM_003597.4 [O14901-1] |
Genome annotation databases
Ensembli | ENST00000305883; ENSP00000307023; ENSG00000172059 [O14901-1] ENST00000535335; ENSP00000442722; ENSG00000172059 [O14901-2] ENST00000540845; ENSP00000444690; ENSG00000172059 [O14901-2] |
GeneIDi | 8462 |
KEGGi | hsa:8462 |
UCSCi | uc010yjc.2, human [O14901-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF028008 mRNA Translation: AAC61880.1 AF272830 mRNA Translation: AAF75793.1 AK302880 mRNA Translation: BAG64059.1 AC104794 Genomic DNA No translation available. CH471053 Genomic DNA Translation: EAX00972.1 BC063286 mRNA Translation: AAH63286.1 BC069383 mRNA Translation: AAH69383.1 BC074922 mRNA Translation: AAH74922.1 |
CCDSi | CCDS1668.1 [O14901-1] CCDS54333.1 [O14901-2] |
RefSeqi | NP_001171187.1, NM_001177716.1 [O14901-2] NP_001171189.1, NM_001177718.1 [O14901-2] NP_003588.1, NM_003597.4 [O14901-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1PO4 | model | - | A | 40-52 | [»] | |
SMRi | O14901 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114040, 21 interactors |
ELMi | O14901 |
IntActi | O14901, 238 interactors |
STRINGi | 9606.ENSP00000307023 |
PTM databases
iPTMneti | O14901 |
PhosphoSitePlusi | O14901 |
Genetic variation databases
BioMutai | KLF11 |
Proteomic databases
jPOSTi | O14901 |
MassIVEi | O14901 |
PaxDbi | O14901 |
PeptideAtlasi | O14901 |
PRIDEi | O14901 |
ProteomicsDBi | 48287 [O14901-1] 48288 [O14901-2] |
Protocols and materials databases
Antibodypediai | 12498, 340 antibodies |
Genome annotation databases
Ensembli | ENST00000305883; ENSP00000307023; ENSG00000172059 [O14901-1] ENST00000535335; ENSP00000442722; ENSG00000172059 [O14901-2] ENST00000540845; ENSP00000444690; ENSG00000172059 [O14901-2] |
GeneIDi | 8462 |
KEGGi | hsa:8462 |
UCSCi | uc010yjc.2, human [O14901-1] |
Organism-specific databases
CTDi | 8462 |
DisGeNETi | 8462 |
GeneCardsi | KLF11 |
GeneReviewsi | KLF11 |
HGNCi | HGNC:11811, KLF11 |
HPAi | ENSG00000172059, Low tissue specificity |
MalaCardsi | KLF11 |
MIMi | 603301, gene 606391, phenotype 610508, phenotype |
neXtProti | NX_O14901 |
OpenTargetsi | ENSG00000172059 |
Orphaneti | 552, MODY |
PharmGKBi | PA36518 |
VEuPathDBi | HostDB:ENSG00000172059.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000155982 |
HOGENOMi | CLU_046370_0_0_1 |
InParanoidi | O14901 |
OMAi | TCKPRPL |
PhylomeDBi | O14901 |
TreeFami | TF315506 |
Enzyme and pathway databases
PathwayCommonsi | O14901 |
SignaLinki | O14901 |
SIGNORi | O14901 |
Miscellaneous databases
BioGRID-ORCSi | 8462, 4 hits in 897 CRISPR screens |
ChiTaRSi | KLF11, human |
GeneWikii | KLF11 |
GenomeRNAii | 8462 |
Pharosi | O14901, Tbio |
PROi | PR:O14901 |
RNActi | O14901, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000172059, Expressed in secondary oocyte and 222 other tissues |
ExpressionAtlasi | O14901, baseline and differential |
Genevisiblei | O14901, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KLF11_HUMAN | |
Accessioni | O14901Primary (citable) accession number: O14901 Secondary accession number(s): B4DZE7, Q9EPF4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | November 1, 1998 | |
Last modified: | February 10, 2021 | |
This is version 189 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families