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Protein

Krueppel-like factor 11

Gene

KLF11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor (PubMed:9748269, PubMed:10207080). Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth (PubMed:9748269, PubMed:10207080, PubMed:16131492). Represses transcription of SMAD7 which enhances TGF-beta signaling (By similarity). Induces apoptosis (By similarity).By similarity2 Publications

Caution

PubMed:11087666 sequence was originally thought to originate from mouse.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri394 – 418C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri424 – 448C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri454 – 476C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processApoptosis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SignaLinkiO14901
SIGNORiO14901

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 11
Alternative name(s):
Transforming growth factor-beta-inducible early growth response protein 2
Short name:
TGFB-inducible early growth response protein 2
Short name:
TIEG-2
Gene namesi
Name:KLF11
Synonyms:FKLF, TIEG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000172059.10
HGNCiHGNC:11811 KLF11
MIMi603301 gene
neXtProtiNX_O14901

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Maturity-onset diabetes of the young 7 (MODY7)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
See also OMIM:610508
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031523220T → M in MODY7; absent in one family member with diabetes; increased repression activity; no alteration in binding affinity to SIN3A. 1 PublicationCorresponds to variant dbSNP:rs34336420EnsemblClinVar.1
Natural variantiVAR_031524347A → S in MODY7; increased repression activity; no alteration in binding affinity to SIN3A. 1 PublicationCorresponds to variant dbSNP:rs121912645EnsemblClinVar.1

Keywords - Diseasei

Diabetes mellitus, Disease mutation

Organism-specific databases

DisGeNETi8462
MalaCardsiKLF11
MIMi606391 phenotype
610508 phenotype
OpenTargetsiENSG00000172059
Orphaneti552 MODY
PharmGKBiPA36518

Polymorphism and mutation databases

BioMutaiKLF11

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471801 – 512Krueppel-like factor 11Add BLAST512

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei124PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO14901
PeptideAtlasiO14901
PRIDEiO14901
ProteomicsDBi48287
48288 [O14901-2]

PTM databases

iPTMnetiO14901
PhosphoSitePlusiO14901

Expressioni

Tissue specificityi

Ubiquitous. Higher expression in erythroid cells.1 Publication

Inductioni

By TGFB1.1 Publication

Gene expression databases

BgeeiENSG00000172059 Expressed in 208 organ(s), highest expression level in secondary oocyte
CleanExiHS_KLF11
ExpressionAtlasiO14901 baseline and differential
GenevisibleiO14901 HS

Organism-specific databases

HPAiHPA058276

Interactioni

Subunit structurei

Interacts with SIN3A.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi114040, 16 interactors
ELMiO14901
IntActiO14901, 11 interactors
STRINGi9606.ENSP00000307023

Structurei

3D structure databases

ProteinModelPortaliO14901
SMRiO14901
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri394 – 418C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri424 – 448C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri454 – 476C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118984
HOGENOMiHOG000059558
HOVERGENiHBG052264
InParanoidiO14901
KOiK09209
OMAiCMTPPQS
OrthoDBiEOG091G1BN0
PhylomeDBiO14901
TreeFamiTF315506

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O14901-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHTPDFAGPD DARAVDIMDI CESILERKRH DSERSTCSIL EQTDMEAVEA
60 70 80 90 100
LVCMSSWGQR SQKGDLLRIR PLTPVSDSGD VTTTVHMDAA TPELPKDFHS
110 120 130 140 150
LSTLCITPPQ SPDLVEPSTR TPVSPQVTDS KACTATDVLQ SSAVVARALS
160 170 180 190 200
GGAERGLLGL EPVPSSPCRA KGTSVIRHTG ESPAACFPTI QTPDCRLSDS
210 220 230 240 250
REGEEQLLGH FETLQDTHLT DSLLSTNLVS CQPCLHKSGG LLLTDKGQQA
260 270 280 290 300
GWPGAVQTCS PKNYENDLPR KTTPLISVSV PAPPVLCQMI PVTGQSSMLP
310 320 330 340 350
AFLKPPPQLS VGTVRPILAQ AAPAPQPVFV GPAVPQGAVM LVLPQGALPP
360 370 380 390 400
PAPCAANVMA AGNTKLLPLA PAPVFITSSQ NCVPQVDFSR RRNYVCSFPG
410 420 430 440 450
CRKTYFKSSH LKAHLRTHTG EKPFNCSWDG CDKKFARSDE LSRHRRTHTG
460 470 480 490 500
EKKFVCPVCD RRFMRSDHLT KHARRHMTTK KIPGWQAEVG KLNRIASAES
510
PGSPLVSMPA SA
Length:512
Mass (Da):55,139
Last modified:November 1, 1998 - v2
Checksum:iA69863B5467FB068
GO
Isoform 2 (identifier: O14901-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: Missing.

Show »
Length:495
Mass (Da):53,329
Checksum:i08456765041CB571
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EX78E7EX78_HUMAN
Krueppel-like factor 11
KLF11
163Annotation score:
C9JM94C9JM94_HUMAN
Krueppel-like factor 11
KLF11
122Annotation score:
B5MCC4B5MCC4_HUMAN
Krueppel-like factor 11
KLF11
127Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti125P → S (PubMed:11087666).Curated1
Sequence conflicti144 – 150VVARALS → QWPDSD (PubMed:11087666).Curated7
Sequence conflicti371P → L (PubMed:11087666).Curated1
Sequence conflicti415L → V (PubMed:11087666).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03152262Q → R High frequency in individuals with diabetes mellitus type 2; increased repression activity; increased binding to SIN3A; impairs activation of insulin promoter. 1 PublicationCorresponds to variant dbSNP:rs35927125EnsemblClinVar.1
Natural variantiVAR_031523220T → M in MODY7; absent in one family member with diabetes; increased repression activity; no alteration in binding affinity to SIN3A. 1 PublicationCorresponds to variant dbSNP:rs34336420EnsemblClinVar.1
Natural variantiVAR_031524347A → S in MODY7; increased repression activity; no alteration in binding affinity to SIN3A. 1 PublicationCorresponds to variant dbSNP:rs121912645EnsemblClinVar.1
Natural variantiVAR_052717378S → F. Corresponds to variant dbSNP:rs35476458Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0426951 – 17Missing in isoform 2. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF028008 mRNA Translation: AAC61880.1
AF272830 mRNA Translation: AAF75793.1
AK302880 mRNA Translation: BAG64059.1
AC104794 Genomic DNA No translation available.
CH471053 Genomic DNA Translation: EAX00972.1
BC063286 mRNA Translation: AAH63286.1
BC069383 mRNA Translation: AAH69383.1
BC074922 mRNA Translation: AAH74922.1
CCDSiCCDS1668.1 [O14901-1]
CCDS54333.1 [O14901-2]
RefSeqiNP_001171187.1, NM_001177716.1 [O14901-2]
NP_001171189.1, NM_001177718.1 [O14901-2]
NP_003588.1, NM_003597.4 [O14901-1]
UniGeneiHs.12229

Genome annotation databases

EnsembliENST00000305883; ENSP00000307023; ENSG00000172059 [O14901-1]
ENST00000535335; ENSP00000442722; ENSG00000172059 [O14901-2]
ENST00000540845; ENSP00000444690; ENSG00000172059 [O14901-2]
GeneIDi8462
KEGGihsa:8462
UCSCiuc010yjc.2 human [O14901-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF028008 mRNA Translation: AAC61880.1
AF272830 mRNA Translation: AAF75793.1
AK302880 mRNA Translation: BAG64059.1
AC104794 Genomic DNA No translation available.
CH471053 Genomic DNA Translation: EAX00972.1
BC063286 mRNA Translation: AAH63286.1
BC069383 mRNA Translation: AAH69383.1
BC074922 mRNA Translation: AAH74922.1
CCDSiCCDS1668.1 [O14901-1]
CCDS54333.1 [O14901-2]
RefSeqiNP_001171187.1, NM_001177716.1 [O14901-2]
NP_001171189.1, NM_001177718.1 [O14901-2]
NP_003588.1, NM_003597.4 [O14901-1]
UniGeneiHs.12229

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PO4model-A40-52[»]
ProteinModelPortaliO14901
SMRiO14901
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114040, 16 interactors
ELMiO14901
IntActiO14901, 11 interactors
STRINGi9606.ENSP00000307023

PTM databases

iPTMnetiO14901
PhosphoSitePlusiO14901

Polymorphism and mutation databases

BioMutaiKLF11

Proteomic databases

PaxDbiO14901
PeptideAtlasiO14901
PRIDEiO14901
ProteomicsDBi48287
48288 [O14901-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305883; ENSP00000307023; ENSG00000172059 [O14901-1]
ENST00000535335; ENSP00000442722; ENSG00000172059 [O14901-2]
ENST00000540845; ENSP00000444690; ENSG00000172059 [O14901-2]
GeneIDi8462
KEGGihsa:8462
UCSCiuc010yjc.2 human [O14901-1]

Organism-specific databases

CTDi8462
DisGeNETi8462
EuPathDBiHostDB:ENSG00000172059.10
GeneCardsiKLF11
HGNCiHGNC:11811 KLF11
HPAiHPA058276
MalaCardsiKLF11
MIMi603301 gene
606391 phenotype
610508 phenotype
neXtProtiNX_O14901
OpenTargetsiENSG00000172059
Orphaneti552 MODY
PharmGKBiPA36518
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118984
HOGENOMiHOG000059558
HOVERGENiHBG052264
InParanoidiO14901
KOiK09209
OMAiCMTPPQS
OrthoDBiEOG091G1BN0
PhylomeDBiO14901
TreeFamiTF315506

Enzyme and pathway databases

SignaLinkiO14901
SIGNORiO14901

Miscellaneous databases

ChiTaRSiKLF11 human
GeneWikiiKLF11
GenomeRNAii8462
PROiPR:O14901
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172059 Expressed in 208 organ(s), highest expression level in secondary oocyte
CleanExiHS_KLF11
ExpressionAtlasiO14901 baseline and differential
GenevisibleiO14901 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiKLF11_HUMAN
AccessioniPrimary (citable) accession number: O14901
Secondary accession number(s): B4DZE7, Q9EPF4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 174 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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