KLF11

Functionⁱ

Transcription factor (PubMed:9748269, PubMed:10207080). Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth (PubMed:9748269, PubMed:10207080, PubMed:16131492). Represses transcription of SMAD7 which enhances TGF-beta signaling (By similarity). Induces apoptosis (By similarity).By similarity2 Publications

Caution

PubMed:11087666 sequence was originally thought to originate from mouse.Curated

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	394 – 418	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	424 – 448	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	454 – 476	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

DNA-binding transcription factor activity
Source: ProtInc
Traceable author statementⁱ
- 9748269
DNA-binding transcription factor activity, RNA polymerase II-specific
Source: BHF-UCL
Inferred from direct assayⁱ
- 21171965
metal ion binding Source: UniProtKB-KW
transcription regulatory region DNA binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 21171965

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic process Source: UniProtKB-KW
cellular response to peptide Source: Ensembl
negative regulation of cell proliferation
Source: BHF-UCL
Inferred from direct assayⁱ
- 21171965
negative regulation of transcription by RNA polymerase II
Source: BHF-UCL
Inferred from direct assayⁱ
- 21171965
positive regulation of apoptotic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 21171965
regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of transcription involved in G1/S transition of mitotic cell cycle
Source: BHF-UCL
Inferred from direct assayⁱ
- 21171965
transcription by RNA polymerase II
Source: ProtInc
Traceable author statementⁱ
- 9748269

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding, Repressor
Biological process	Apoptosis, Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

SignaLinkⁱ	O14901
SIGNORⁱ	O14901

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Krueppel-like factor 11 Alternative name(s): Transforming growth factor-beta-inducible early growth response protein 2 Short name: TGFB-inducible early growth response protein 2 Short name: TIEG-2
Gene namesⁱ	Name:KLF11 Synonyms:FKLF, TIEG2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000172059.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11811 KLF11
MIMⁱ	603301 gene
neXtProtⁱ	NX_O14901

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Maturity-onset diabetes of the young 7 (MODY7)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_031523	220	T → M in MODY7; absent in one family member with diabetes; increased repression activity; no alteration in binding affinity to SIN3A. 1 PublicationCorresponds to variant dbSNP:rs34336420EnsemblClinVar.		1
Natural variantⁱVAR_031524	347	A → S in MODY7; increased repression activity; no alteration in binding affinity to SIN3A. 1 PublicationCorresponds to variant dbSNP:rs121912645EnsemblClinVar.		1

Keywords - Diseaseⁱ

Diabetes mellitus, Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8462
MalaCards human disease database More...MalaCardsⁱ	KLF11
MIMⁱ	606391 phenotype 610508 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000172059
Orphanetⁱ	552 MODY
PharmGKBⁱ	PA36518

Polymorphism and mutation databases

BioMutaⁱ	KLF11

BioMutaⁱ

KLF11

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047180	1 – 512	Krueppel-like factor 11Add BLAST		512

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	124	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	O14901
PeptideAtlas More...PeptideAtlasⁱ	O14901
PRIDEⁱ	O14901
ProteomicsDBⁱ	48287 48288 [O14901-2]

PTM databases

iPTMnetⁱ	O14901
PhosphoSitePlusⁱ	O14901

Expressionⁱ

Tissue specificityⁱ

Ubiquitous. Higher expression in erythroid cells.1 Publication

Inductionⁱ

By TGFB1.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000172059 Expressed in 208 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_KLF11
ExpressionAtlasⁱ	O14901 baseline and differential
Genevisibleⁱ	O14901 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA058276

HPAⁱ

HPA058276

Interactionⁱ

Subunit structureⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
APPBP2	Q92624	3	EBI-948266,EBI-743771
TXNDC9	O14530	3	EBI-948266,EBI-707554

Protein-protein interaction databases

BioGridⁱ	114040, 16 interactors
ELMⁱ	O14901
IntActⁱ	O14901, 11 interactors
STRINGⁱ	9606.ENSP00000307023

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O14901
SMRⁱ	O14901
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the Sp1 C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	394 – 418	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	424 – 448	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	454 – 476	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118984
HOGENOMⁱ	HOG000059558
HOVERGENⁱ	HBG052264
InParanoidⁱ	O14901
KEGG Orthology (KO) More...KOⁱ	K09209
OMAⁱ	CMTPPQS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G1BN0
PhylomeDBⁱ	O14901
TreeFamⁱ	TF315506

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 3 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O14901-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHTPDFAGPD DARAVDIMDI CESILERKRH DSERSTCSIL EQTDMEAVEA 
        60         70         80         90        100
LVCMSSWGQR SQKGDLLRIR PLTPVSDSGD VTTTVHMDAA TPELPKDFHS 
       110        120        130        140        150
LSTLCITPPQ SPDLVEPSTR TPVSPQVTDS KACTATDVLQ SSAVVARALS 
       160        170        180        190        200
GGAERGLLGL EPVPSSPCRA KGTSVIRHTG ESPAACFPTI QTPDCRLSDS 
       210        220        230        240        250
REGEEQLLGH FETLQDTHLT DSLLSTNLVS CQPCLHKSGG LLLTDKGQQA 
       260        270        280        290        300
GWPGAVQTCS PKNYENDLPR KTTPLISVSV PAPPVLCQMI PVTGQSSMLP 
       310        320        330        340        350
AFLKPPPQLS VGTVRPILAQ AAPAPQPVFV GPAVPQGAVM LVLPQGALPP 
       360        370        380        390        400
PAPCAANVMA AGNTKLLPLA PAPVFITSSQ NCVPQVDFSR RRNYVCSFPG 
       410        420        430        440        450
CRKTYFKSSH LKAHLRTHTG EKPFNCSWDG CDKKFARSDE LSRHRRTHTG 
       460        470        480        490        500
EKKFVCPVCD RRFMRSDHLT KHARRHMTTK KIPGWQAEVG KLNRIASAES 
       510 
PGSPLVSMPA SA

Length:512

Mass (Da):55,139

Last modified:November 1, 1998 - v2

Checksum:ⁱA69863B5467FB068

GO

Isoform 2 (identifier: O14901-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-17: Missing.

« Hide

        10         20         30         40         50
MDICESILER KRHDSERSTC SILEQTDMEA VEALVCMSSW GQRSQKGDLL 
        60         70         80         90        100
RIRPLTPVSD SGDVTTTVHM DAATPELPKD FHSLSTLCIT PPQSPDLVEP 
       110        120        130        140        150
STRTPVSPQV TDSKACTATD VLQSSAVVAR ALSGGAERGL LGLEPVPSSP 
       160        170        180        190        200
CRAKGTSVIR HTGESPAACF PTIQTPDCRL SDSREGEEQL LGHFETLQDT 
       210        220        230        240        250
HLTDSLLSTN LVSCQPCLHK SGGLLLTDKG QQAGWPGAVQ TCSPKNYEND 
       260        270        280        290        300
LPRKTTPLIS VSVPAPPVLC QMIPVTGQSS MLPAFLKPPP QLSVGTVRPI 
       310        320        330        340        350
LAQAAPAPQP VFVGPAVPQG AVMLVLPQGA LPPPAPCAAN VMAAGNTKLL 
       360        370        380        390        400
PLAPAPVFIT SSQNCVPQVD FSRRRNYVCS FPGCRKTYFK SSHLKAHLRT 
       410        420        430        440        450
HTGEKPFNCS WDGCDKKFAR SDELSRHRRT HTGEKKFVCP VCDRRFMRSD 
       460        470        480        490 
HLTKHARRHM TTKKIPGWQA EVGKLNRIAS AESPGSPLVS MPASA

Show »

Length:495

Mass (Da):53,329

Checksum:ⁱ08456765041CB571

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E7EX78	E7EX78_HUMAN	Krueppel-like factor 11 Krueppel-like factor 11	KLF11	163	Annotation score:
C9JM94	C9JM94_HUMAN	Krueppel-like factor 11 Krueppel-like factor 11	KLF11	122	Annotation score:
B5MCC4	B5MCC4_HUMAN	Krueppel-like factor 11 Krueppel-like factor 11	KLF11	127	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	125	P → S (PubMed:11087666).Curated	1
Sequence conflictⁱ	144 – 150	VVARALS → QWPDSD (PubMed:11087666).Curated	7
Sequence conflictⁱ	371	P → L (PubMed:11087666).Curated	1
Sequence conflictⁱ	415	L → V (PubMed:11087666).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_031522	62	Q → R High frequency in individuals with diabetes mellitus type 2; increased repression activity; increased binding to SIN3A; impairs activation of insulin promoter. 1 PublicationCorresponds to variant dbSNP:rs35927125EnsemblClinVar.	1
Natural variantⁱVAR_031523	220	T → M in MODY7; absent in one family member with diabetes; increased repression activity; no alteration in binding affinity to SIN3A. 1 PublicationCorresponds to variant dbSNP:rs34336420EnsemblClinVar.	1
Natural variantⁱVAR_031524	347	A → S in MODY7; increased repression activity; no alteration in binding affinity to SIN3A. 1 PublicationCorresponds to variant dbSNP:rs121912645EnsemblClinVar.	1
Natural variantⁱVAR_052717	378	S → F. Corresponds to variant dbSNP:rs35476458Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_042695	1 – 17	Missing in isoform 2. 1 PublicationAdd BLAST		17

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF028008 mRNA Translation: AAC61880.1 AF272830 mRNA Translation: AAF75793.1 AK302880 mRNA Translation: BAG64059.1 AC104794 Genomic DNA No translation available. CH471053 Genomic DNA Translation: EAX00972.1 BC063286 mRNA Translation: AAH63286.1 BC069383 mRNA Translation: AAH69383.1 BC074922 mRNA Translation: AAH74922.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1668.1 [O14901-1] CCDS54333.1 [O14901-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001171187.1, NM_001177716.1 [O14901-2] NP_001171189.1, NM_001177718.1 [O14901-2] NP_003588.1, NM_003597.4 [O14901-1]
UniGeneⁱ	Hs.12229

Genome annotation databases

Ensemblⁱ	ENST00000305883; ENSP00000307023; ENSG00000172059 [O14901-1] ENST00000535335; ENSP00000442722; ENSG00000172059 [O14901-2] ENST00000540845; ENSP00000444690; ENSG00000172059 [O14901-2]
GeneIDⁱ	8462
KEGGⁱ	hsa:8462
UCSC genome browser More...UCSCⁱ	uc010yjc.2 human [O14901-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
O14901	cDNA FLJ77882, highly similar to Homo sapiens kruppel-like fetal and embryonic globin gene activator (FKLF) mRNA		HUMAN		512	UniRef100_O14901
KLF11 isoform 6 (Fragment)		PANTR		122
Isoform 2 of Krueppel-like factor 11		HUMAN		495
Krueppel-like factor 11 (Fragment)		HUMAN		122
Krueppel-like factor 11 (Fragment)		HUMAN		127
+2

Protein	Similar proteins		Species	Score	Length	Source
O14901	cDNA FLJ77882, highly similar to Homo sapiens kruppel-like fetal and embryonic globin gene activator (FKLF) mRNA		HUMAN		512	UniRef90_O14901
KLF11 isoform 6 (Fragment)		PANTR		122
Uncharacterized protein		CERAT		513
KLF11 isoform 2		PONAB		512
Uncharacterized protein		MACMU		512
+35

Protein	Similar proteins		Species	Score	Length	Source
O14901	Krueppel-like factor 11		MOUSE		502	UniRef50_O14901
cDNA FLJ77882, highly similar to Homo sapiens kruppel-like fetal and embryonic globin gene activator (FKLF) mRNA		HUMAN		512
KLF11 isoform 6 (Fragment)		PANTR		122
Uncharacterized protein		CERAT		513
Uncharacterized protein		MACMU		512
+163

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF028008 mRNA Translation: AAC61880.1 AF272830 mRNA Translation: AAF75793.1 AK302880 mRNA Translation: BAG64059.1 AC104794 Genomic DNA No translation available. CH471053 Genomic DNA Translation: EAX00972.1 BC063286 mRNA Translation: AAH63286.1 BC069383 mRNA Translation: AAH69383.1 BC074922 mRNA Translation: AAH74922.1
CCDSⁱ	CCDS1668.1 [O14901-1] CCDS54333.1 [O14901-2]
RefSeqⁱ	NP_001171187.1, NM_001177716.1 [O14901-2] NP_001171189.1, NM_001177718.1 [O14901-2] NP_003588.1, NM_003597.4 [O14901-1]
UniGeneⁱ	Hs.12229

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1PO4	model	-	A	40-52	[»]
ProteinModelPortalⁱ	O14901
SMRⁱ	O14901
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114040, 16 interactors
ELMⁱ	O14901
IntActⁱ	O14901, 11 interactors
STRINGⁱ	9606.ENSP00000307023

PTM databases

iPTMnetⁱ	O14901
PhosphoSitePlusⁱ	O14901

Polymorphism and mutation databases

BioMutaⁱ	KLF11

BioMutaⁱ

KLF11

Proteomic databases

PaxDbⁱ	O14901
PeptideAtlasⁱ	O14901
PRIDEⁱ	O14901
ProteomicsDBⁱ	48287 48288 [O14901-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000305883; ENSP00000307023; ENSG00000172059 [O14901-1] ENST00000535335; ENSP00000442722; ENSG00000172059 [O14901-2] ENST00000540845; ENSP00000444690; ENSG00000172059 [O14901-2]
GeneIDⁱ	8462
KEGGⁱ	hsa:8462
UCSCⁱ	uc010yjc.2 human [O14901-1]

Organism-specific databases

CTDⁱ	8462
DisGeNETⁱ	8462
EuPathDBⁱ	HostDB:ENSG00000172059.10
GeneCardsⁱ	KLF11
HGNCⁱ	HGNC:11811 KLF11
HPAⁱ	HPA058276
MalaCardsⁱ	KLF11
MIMⁱ	603301 gene 606391 phenotype 610508 phenotype
neXtProtⁱ	NX_O14901
OpenTargetsⁱ	ENSG00000172059
Orphanetⁱ	552 MODY
PharmGKBⁱ	PA36518
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00760000118984
HOGENOMⁱ	HOG000059558
HOVERGENⁱ	HBG052264
InParanoidⁱ	O14901
KOⁱ	K09209
OMAⁱ	CMTPPQS
OrthoDBⁱ	EOG091G1BN0
PhylomeDBⁱ	O14901
TreeFamⁱ	TF315506

Enzyme and pathway databases

SignaLinkⁱ	O14901
SIGNORⁱ	O14901

Miscellaneous databases

ChiTaRSⁱ	KLF11 human
GeneWikiⁱ	KLF11
GenomeRNAiⁱ	8462
Protein Ontology More...PROⁱ	PR:O14901
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000172059 Expressed in 208 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_KLF11
ExpressionAtlasⁱ	O14901 baseline and differential
Genevisibleⁱ	O14901 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 3 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KLF11_HUMAN
Accessionⁱ	O14901Primary (citable) accession number: O14901 Secondary accession number(s): B4DZE7, Q9EPF4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
	Last sequence update:	November 1, 1998
	Last modified:	November 7, 2018
	This is version 174 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - O14901 (KLF11_HUMAN)

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Krueppel-like factor 11

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ