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Protein

Transmembrane 4 L6 family member 5

Gene

TM4SF5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane 4 L6 family member 5
Alternative name(s):
Tetraspan transmembrane protein L6H
Gene namesi
Name:TM4SF5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000142484.6
HGNCiHGNC:11857 TM4SF5
MIMi604657 gene
neXtProtiNX_O14894

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9CytoplasmicSequence analysis9
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Topological domaini31 – 46ExtracellularSequence analysisAdd BLAST16
Transmembranei47 – 67HelicalSequence analysisAdd BLAST21
Topological domaini68 – 90CytoplasmicSequence analysisAdd BLAST23
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Topological domaini112 – 157ExtracellularSequence analysisAdd BLAST46
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Topological domaini179 – 197CytoplasmicSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9032
OpenTargetsiENSG00000142484
PharmGKBiPA36558

Polymorphism and mutation databases

BioMutaiTM4SF5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002193031 – 197Transmembrane 4 L6 family member 5Add BLAST197

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi138N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi155N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO14894
PeptideAtlasiO14894
PRIDEiO14894
ProteomicsDBi48285

Expressioni

Tissue specificityi

Intestine. Overexpressed in pancreatic cancers.

Gene expression databases

BgeeiENSG00000142484
CleanExiHS_TM4SF5
GenevisibleiO14894 HS

Organism-specific databases

HPAiHPA055674

Interactioni

Protein-protein interaction databases

IntActiO14894, 1 interactor
STRINGi9606.ENSP00000270560

Structurei

3D structure databases

ProteinModelPortaliO14894
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L6 tetraspanin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXVM Eukaryota
ENOG4111JUZ LUCA
GeneTreeiENSGT00390000010992
HOGENOMiHOG000030899
HOVERGENiHBG000076
InParanoidiO14894
OMAiNRCRMLR
OrthoDBiEOG091G0QEF
PhylomeDBiO14894
TreeFamiTF331371

Family and domain databases

InterProiView protein in InterPro
IPR008661 L6_membrane
PANTHERiPTHR14198 PTHR14198, 1 hit
PfamiView protein in Pfam
PF05805 L6_membrane, 1 hit

Sequencei

Sequence statusi: Complete.

O14894-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCTGKCARCV GLSLITLCLV CIVANALLLV PNGETSWTNT NHLSLQVWLM
60 70 80 90 100
GGFIGGGLMV LCPGIAAVRA GGKGCCGAGC CGNRCRMLRS VFSSAFGVLG
110 120 130 140 150
AIYCLSVSGA GLRNGPRCLM NGEWGYHFED TAGAYLLNRT LWDRCEAPPR
160 170 180 190
VVPWNVTLFS LLVAASCLEI VLCGIQLVNA TIGVFCGDCR KKQDTPH
Length:197
Mass (Da):20,823
Last modified:June 21, 2005 - v2
Checksum:i051AEB5ECCE1075C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19L → F in AAB82947 (PubMed:9479038).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF027204 mRNA Translation: AAB82947.1
CR456925 mRNA Translation: CAG33206.1
BC069519 mRNA Translation: AAH69519.1
BC093688 mRNA Translation: AAH93688.1
BC117163 mRNA Translation: AAI17164.1
CCDSiCCDS11054.1
PIRiJC6544
RefSeqiNP_003954.2, NM_003963.2
UniGeneiHs.184194

Genome annotation databases

EnsembliENST00000270560; ENSP00000270560; ENSG00000142484
GeneIDi9032
KEGGihsa:9032
UCSCiuc002fyw.1 human

Similar proteinsi

Entry informationi

Entry nameiT4S5_HUMAN
AccessioniPrimary (citable) accession number: O14894
Secondary accession number(s): Q17RW9, Q6IB79
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 21, 2005
Last modified: July 18, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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