UniProtKB - O14893 (GEMI2_HUMAN)
Gem-associated protein 2
GEMIN2
Functioni
Caution
GO - Biological processi
- import into nucleus Source: Reactome
- mRNA processing Source: ProtInc
- RNA splicing Source: UniProtKB
- RNA splicing, via transesterification reactions Source: UniProtKB
- spliceosomal complex assembly Source: ProtInc
- spliceosomal snRNP assembly Source: UniProtKB
Keywordsi
Biological process | mRNA processing, mRNA splicing |
Enzyme and pathway databases
PathwayCommonsi | O14893 |
Reactomei | R-HSA-191859, snRNP Assembly |
SIGNORi | O14893 |
Names & Taxonomyi
Protein namesi | Recommended name: Gem-associated protein 2Short name: Gemin-2 Alternative name(s): Component of gems 2 Survival of motor neuron protein-interacting protein 1 Short name: SMN-interacting protein 1 |
Gene namesi | Name:GEMIN2 Synonyms:SIP1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10884, GEMIN2 |
MIMi | 602595, gene |
neXtProti | NX_O14893 |
VEuPathDBi | HostDB:ENSG00000092208.16 |
Subcellular locationi
Cytosol
- cytosol Source: UniProtKB
Nucleus
- Gemini of coiled bodies Source: UniProtKB
- nuclear body Source: HPA
- nucleolus Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
- spliceosomal complex Source: InterPro
Other locations
- cytoplasm Source: GO_Central
- SMN complex Source: UniProtKB
- SMN-Sm protein complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 8487 |
GeneReviewsi | GEMIN2 |
MalaCardsi | GEMIN2 |
OpenTargetsi | ENSG00000092208 |
PharmGKBi | PA35784 |
Miscellaneous databases
Pharosi | O14893, Tbio |
Genetic variation databases
BioMutai | GEMIN2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000087455 | 1 – 280 | Gem-associated protein 2Add BLAST | 280 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 81 | PhosphoserineCombined sources | 1 | |
Modified residuei | 166 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | O14893 |
jPOSTi | O14893 |
MassIVEi | O14893 |
MaxQBi | O14893 |
PaxDbi | O14893 |
PeptideAtlasi | O14893 |
PRIDEi | O14893 |
ProteomicsDBi | 48281 [O14893-1] 48282 [O14893-2] 48283 [O14893-3] 48284 [O14893-4] |
PTM databases
iPTMneti | O14893 |
PhosphoSitePlusi | O14893 |
Expressioni
Gene expression databases
Bgeei | ENSG00000092208, Expressed in buccal mucosa cell and 227 other tissues |
ExpressionAtlasi | O14893, baseline and differential |
Genevisiblei | O14893, HS |
Organism-specific databases
HPAi | ENSG00000092208, Low tissue specificity |
Interactioni
Subunit structurei
Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG.
Interacts directly with GEMIN5.
3 PublicationsBinary interactionsi
Hide detailsO14893
Protein-protein interaction databases
BioGRIDi | 114059, 94 interactors |
ComplexPortali | CPX-6031, SMN complex |
CORUMi | O14893 |
DIPi | DIP-32605N |
IntActi | O14893, 59 interactors |
MINTi | O14893 |
STRINGi | 9606.ENSP00000308533 |
Miscellaneous databases
RNActi | O14893, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | O14893 |
SMRi | O14893 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 101 – 106 | Poly-Gln | 6 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG502QPK4, Eukaryota |
GeneTreei | ENSGT00390000013814 |
HOGENOMi | CLU_053222_0_0_1 |
InParanoidi | O14893 |
OMAi | LYERKRC |
OrthoDBi | 1235594at2759 |
PhylomeDBi | O14893 |
TreeFami | TF105864 |
Family and domain databases
IDEALi | IID00524 |
InterProi | View protein in InterPro IPR017364, GEMIN2 IPR035426, Gemin2/Brr1 |
Pfami | View protein in Pfam PF04938, SIP1, 1 hit |
PIRSFi | PIRSF038038, SMN_Gemin2, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRRAELAGLK TMAWVPAESA VEELMPRLLP VEPCDLTEGF DPSVPPRTPQ
60 70 80 90 100
EYLRRVQIEA AQCPDVVVAQ IDPKKLKRKQ SVNISLSGCQ PAPEGYSPTL
110 120 130 140 150
QWQQQQVAQF STVRQNVNKH RSHWKSQQLD SNVTMPKSED EEGWKKFCLG
160 170 180 190 200
EKLCADGAVG PATNESPGID YVQIGFPPLL SIVSRMNQAT VTSVLEYLSN
210 220 230 240 250
WFGERDFTPE LGRWLYALLA CLEKPLLPEA HSLIRQLARR CSEVRLLVDS
260 270 280
KDDERVPALN LLICLVSRYF DQRDLADEPS
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3B3IU42 | A0A3B3IU42_HUMAN | Gem-associated protein 2 | GEMIN2 | 275 | Annotation score: | ||
H0YEL0 | H0YEL0_HUMAN | Gem-associated protein 2 | GEMIN2 | 220 | Annotation score: | ||
G5EA29 | G5EA29_HUMAN | Gem-associated protein 2 | GEMIN2 SIP1, hCG_21235 | 149 | Annotation score: | ||
H0YDP6 | H0YDP6_HUMAN | Gem-associated protein 2 | GEMIN2 | 197 | Annotation score: | ||
H0YCF4 | H0YCF4_HUMAN | Gem-associated protein 2 | GEMIN2 | 45 | Annotation score: | ||
S4R421 | S4R421_HUMAN | Gem-associated protein 2 | GEMIN2 | 22 | Annotation score: |
Sequence cautioni
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_013543 | 31 – 44 | VEPCD…FDPSV → DRSSSMSRCCGSSN in isoform 4. 1 PublicationAdd BLAST | 14 | |
Alternative sequenceiVSP_013544 | 45 – 280 | Missing in isoform 4. 1 PublicationAdd BLAST | 236 | |
Alternative sequenceiVSP_013545 | 173 – 187 | Missing in isoform 2. 1 PublicationAdd BLAST | 15 | |
Alternative sequenceiVSP_013546 | 249 – 250 | DS → VF in isoform 3. 1 Publication | 2 | |
Alternative sequenceiVSP_013547 | 251 – 280 | Missing in isoform 3. 1 PublicationAdd BLAST | 30 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF027150 mRNA Translation: AAB82297.1 AB037701 mRNA Translation: BAB03508.1 AB037702 mRNA Translation: BAB03509.1 AB037703 mRNA Translation: BAB03510.1 AJ250932 , AJ250933, AJ250934, AJ250935, AJ250936, AJ250937, AJ250938, AJ250939 Genomic DNA Translation: CAC16117.2 Different initiation. AK313947 mRNA Translation: BAG36665.1 BC104968 mRNA Translation: AAI04969.1 |
RefSeqi | NP_001009182.1, NM_001009182.1 NP_001009183.1, NM_001009183.1 NP_003607.1, NM_003616.2 |
Genome annotation databases
Ensembli | ENST00000250379; ENSP00000250379; ENSG00000092208 [O14893-2] ENST00000308317; ENSP00000308533; ENSG00000092208 [O14893-1] ENST00000396249; ENSP00000379548; ENSG00000092208 [O14893-3] ENST00000412033; ENSP00000416827; ENSG00000092208 [O14893-4] |
GeneIDi | 8487 |
KEGGi | hsa:8487 |
UCSCi | uc001wuq.4, human [O14893-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF027150 mRNA Translation: AAB82297.1 AB037701 mRNA Translation: BAB03508.1 AB037702 mRNA Translation: BAB03509.1 AB037703 mRNA Translation: BAB03510.1 AJ250932 , AJ250933, AJ250934, AJ250935, AJ250936, AJ250937, AJ250938, AJ250939 Genomic DNA Translation: CAC16117.2 Different initiation. AK313947 mRNA Translation: BAG36665.1 BC104968 mRNA Translation: AAI04969.1 |
RefSeqi | NP_001009182.1, NM_001009182.1 NP_001009183.1, NM_001009183.1 NP_003607.1, NM_003616.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2LEH | NMR | - | A | 95-280 | [»] | |
5XJL | X-ray | 2.50 | 2 | 1-280 | [»] | |
5XJQ | X-ray | 3.28 | 2 | 1-280 | [»] | |
5XJR | X-ray | 3.12 | 2 | 40-280 | [»] | |
5XJS | X-ray | 3.38 | 2 | 40-280 | [»] | |
5XJT | X-ray | 2.92 | 2 | 1-280 | [»] | |
5XJU | X-ray | 2.58 | 2 | 40-280 | [»] | |
BMRBi | O14893 | |||||
SMRi | O14893 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114059, 94 interactors |
ComplexPortali | CPX-6031, SMN complex |
CORUMi | O14893 |
DIPi | DIP-32605N |
IntActi | O14893, 59 interactors |
MINTi | O14893 |
STRINGi | 9606.ENSP00000308533 |
PTM databases
iPTMneti | O14893 |
PhosphoSitePlusi | O14893 |
Genetic variation databases
BioMutai | GEMIN2 |
Proteomic databases
EPDi | O14893 |
jPOSTi | O14893 |
MassIVEi | O14893 |
MaxQBi | O14893 |
PaxDbi | O14893 |
PeptideAtlasi | O14893 |
PRIDEi | O14893 |
ProteomicsDBi | 48281 [O14893-1] 48282 [O14893-2] 48283 [O14893-3] 48284 [O14893-4] |
Protocols and materials databases
Antibodypediai | 4218, 336 antibodies |
Genome annotation databases
Ensembli | ENST00000250379; ENSP00000250379; ENSG00000092208 [O14893-2] ENST00000308317; ENSP00000308533; ENSG00000092208 [O14893-1] ENST00000396249; ENSP00000379548; ENSG00000092208 [O14893-3] ENST00000412033; ENSP00000416827; ENSG00000092208 [O14893-4] |
GeneIDi | 8487 |
KEGGi | hsa:8487 |
UCSCi | uc001wuq.4, human [O14893-1] |
Organism-specific databases
CTDi | 8487 |
DisGeNETi | 8487 |
GeneCardsi | GEMIN2 |
GeneReviewsi | GEMIN2 |
HGNCi | HGNC:10884, GEMIN2 |
HPAi | ENSG00000092208, Low tissue specificity |
MalaCardsi | GEMIN2 |
MIMi | 602595, gene |
neXtProti | NX_O14893 |
OpenTargetsi | ENSG00000092208 |
PharmGKBi | PA35784 |
VEuPathDBi | HostDB:ENSG00000092208.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QPK4, Eukaryota |
GeneTreei | ENSGT00390000013814 |
HOGENOMi | CLU_053222_0_0_1 |
InParanoidi | O14893 |
OMAi | LYERKRC |
OrthoDBi | 1235594at2759 |
PhylomeDBi | O14893 |
TreeFami | TF105864 |
Enzyme and pathway databases
PathwayCommonsi | O14893 |
Reactomei | R-HSA-191859, snRNP Assembly |
SIGNORi | O14893 |
Miscellaneous databases
BioGRID-ORCSi | 8487, 218 hits in 881 CRISPR screens |
ChiTaRSi | GEMIN2, human |
GenomeRNAii | 8487 |
Pharosi | O14893, Tbio |
PROi | PR:O14893 |
RNActi | O14893, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000092208, Expressed in buccal mucosa cell and 227 other tissues |
ExpressionAtlasi | O14893, baseline and differential |
Genevisiblei | O14893, HS |
Family and domain databases
IDEALi | IID00524 |
InterProi | View protein in InterPro IPR017364, GEMIN2 IPR035426, Gemin2/Brr1 |
Pfami | View protein in Pfam PF04938, SIP1, 1 hit |
PIRSFi | PIRSF038038, SMN_Gemin2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GEMI2_HUMAN | |
Accessioni | O14893Primary (citable) accession number: O14893 Secondary accession number(s): B2R9W8 Q9NS79 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | January 1, 1998 | |
Last modified: | February 10, 2021 | |
This is version 185 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families