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Entry version 175 (17 Jun 2020)
Sequence version 1 (01 Jan 1998)
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Protein

Microsomal glutathione S-transferase 3

Gene

MGST3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes oxydation of hydroxy-fatty acids (PubMed:9278457). Also catalyzes the conjugation of a reduced glutathione to leukotriene A4 in vitro (PubMed:9278457). May participate in the lipid metabolism (PubMed:9278457).1 Publication1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by MK-886 and leukotriene C4.By similarity

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=21 µM for (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionLyase, Oxidoreductase, Transferase

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-156590 Glutathione conjugation
    R-HSA-5423646 Aflatoxin activation and detoxification

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...
    SwissLipidsi
    SLP:000001463

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Microsomal glutathione S-transferase 3Curated
    Short name:
    Microsomal GST-3
    Alternative name(s):
    Glutathione peroxidase MGST31 Publication (EC:1.11.1.-)
    LTC4 synthase MGST31 Publication (EC:4.4.1.201 Publication)
    Microsomal glutathione S-transferase III1 Publication
    Short name:
    Microsomal GST-III1 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:MGST3Imported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000143198.12

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:7064 MGST3

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    604564 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_O14880

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
    Transmembranei71 – 91HelicalSequence analysisAdd BLAST21
    Transmembranei120 – 140HelicalSequence analysisAdd BLAST21

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi150C → S: Abolishes S-acylation; when associated with S-151. 1 Publication1
    Mutagenesisi151C → S: Abolishes S-acylation; when associated with S-150. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    4259

    Open Targets

    More...
    OpenTargetsi
    ENSG00000143198

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA30793

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    O14880 Tbio

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL1743186

    Drug and drug target database

    More...
    DrugBanki
    DB00143 Glutathione

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    MGST3

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002177411 – 152Microsomal glutathione S-transferase 3Add BLAST152

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi150S-palmitoyl cysteine1 Publication1
    Lipidationi151S-palmitoyl cysteine1 Publication1

    Keywords - PTMi

    Lipoprotein, Palmitate

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    O14880

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    O14880

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    O14880

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    O14880

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    O14880

    PeptideAtlas

    More...
    PeptideAtlasi
    O14880

    PRoteomics IDEntifications database

    More...
    PRIDEi
    O14880

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    48280

    Consortium for Top Down Proteomics

    More...
    TopDownProteomicsi
    O14880

    PTM databases

    CarbonylDB database of protein carbonylation sites

    More...
    CarbonylDBi
    O14880

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    O14880

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    O14880

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    O14880

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Predominantly expressed in heart, skeletal muscle, and adrenal cortex. Also found in brain, placenta, liver, kidney, pancreas, thyroid, testis and ovary. Almost absent in lung, thymus and peripheral blood leukocytes.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000143198 Expressed in corpus epididymis and 232 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    O14880 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    O14880 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    ENSG00000143198 Low tissue specificity

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    O14880
    With#Exp.IntAct
    AGPAT4 [Q9NRZ5]3EBI-724754,EBI-1754287
    AGTRAP - isoform 2 [Q6RW13-2]3EBI-724754,EBI-11522760
    APOD [P05090]3EBI-724754,EBI-715495
    APOL2 [Q9BQE5]3EBI-724754,EBI-4290634
    AQP1 [P29972]3EBI-724754,EBI-745213
    AQP10 [Q96PS8]3EBI-724754,EBI-12820279
    AQP3 [Q92482]3EBI-724754,EBI-2808854
    ARL6IP1 [Q15041]3EBI-724754,EBI-714543
    ARL6IP6 [Q8N6S5]3EBI-724754,EBI-2808844
    BET1 [O15155]3EBI-724754,EBI-749204
    BMP10 [O95393]3EBI-724754,EBI-3922513
    C11orf24 [Q96F05]3EBI-724754,EBI-2836238
    CACNG1 [Q06432]3EBI-724754,EBI-9686780
    CCNC [P24863]3EBI-724754,EBI-395261
    CDIPT [O14735]3EBI-724754,EBI-358858
    CLRN1 [P58418]3EBI-724754,EBI-17274839
    CMTM5 - isoform 2 [Q96DZ9-2]3EBI-724754,EBI-11522780
    CREB3L1 [Q96BA8]3EBI-724754,EBI-6942903
    CYBC1 [Q9BQA9]3EBI-724754,EBI-2680384
    ERG28 [Q9UKR5]3EBI-724754,EBI-711490
    FAXDC2 [Q96IV6]3EBI-724754,EBI-12142299
    FUNDC2 [Q9BWH2]3EBI-724754,EBI-714482
    FXYD6 [Q9H0Q3]3EBI-724754,EBI-713304
    GIMAP1 [Q8WWP7]3EBI-724754,EBI-11991950
    GIMAP5 [Q96F15]3EBI-724754,EBI-6166686
    GPR152 [Q8TDT2]3EBI-724754,EBI-13345167
    GPX8 [Q8TED1]3EBI-724754,EBI-11721746
    GRM2 [Q14416]3EBI-724754,EBI-10232876
    HMOX2 [P30519]3EBI-724754,EBI-712096
    ITGAM [P11215]3EBI-724754,EBI-2568251
    LEMD1 [Q68G75]3EBI-724754,EBI-12268900
    LPAR3 [Q9UBY5]3EBI-724754,EBI-12033434
    LRP10 [Q7Z4F1]3EBI-724754,EBI-2830349
    itself3EBI-724754,EBI-724754
    MIP [P30301]3EBI-724754,EBI-8449636
    MRM1 [Q6IN84]3EBI-724754,EBI-5454865
    MTIF3 [Q9H2K0]3EBI-724754,EBI-3923617
    NEU1 [Q99519]3EBI-724754,EBI-721517
    NINJ2 [Q9NZG7]3EBI-724754,EBI-10317425
    NKG7 [Q16617]3EBI-724754,EBI-3919611
    NRAC [Q8N912]3EBI-724754,EBI-12051377
    NRM [Q8IXM6]3EBI-724754,EBI-10262547
    NSG1 [P42857]3EBI-724754,EBI-6380741
    PAGE1 [O75459]3EBI-724754,EBI-2559100
    PLN [P26678]3EBI-724754,EBI-692836
    PLP1 - isoform DM-20 [P60201-2]3EBI-724754,EBI-12188331
    PLP2 [Q04941]3EBI-724754,EBI-608347
    PLPP4 [Q5VZY2]3EBI-724754,EBI-10485931
    PPGB [Q59EV6]3EBI-724754,EBI-14210385
    SCD [O00767]3EBI-724754,EBI-2684237
    SCN3B [Q9NY72]3EBI-724754,EBI-17247926
    SEC22B [O75396]3EBI-724754,EBI-1058865
    SLC1A3 [P43003]3EBI-724754,EBI-359038
    SLC2A5 [P22732]3EBI-724754,EBI-2825135
    SLC35A1 [P78382]3EBI-724754,EBI-12870360
    SLC39A9 [Q9NUM3]3EBI-724754,EBI-2823239
    SLC7A1 [P30825]3EBI-724754,EBI-4289564
    SMCO4 [Q9NRQ5]3EBI-724754,EBI-8640191
    SNAP47 [Q5SQN1]3EBI-724754,EBI-10244848
    SNORC [Q6UX34]3EBI-724754,EBI-11957067
    STX3 [Q13277]3EBI-724754,EBI-1394295
    STX7 [O15400]3EBI-724754,EBI-3221827
    STX8 [Q9UNK0]3EBI-724754,EBI-727240
    SYS1 [Q8N2H4]3EBI-724754,EBI-13075176
    TFAM [Q00059]4EBI-724754,EBI-1049924
    TFRC [P02786]3EBI-724754,EBI-355727
    TMEM107 [Q6UX40]3EBI-724754,EBI-12845616
    TMEM109 [Q9BVC6]3EBI-724754,EBI-1057733
    TMEM120B [A0PK00]3EBI-724754,EBI-10171534
    TMEM140 [Q9NV12]3EBI-724754,EBI-2844246
    TMEM229B [Q8NBD8]3EBI-724754,EBI-12195227
    TMEM60 [Q9H2L4]3EBI-724754,EBI-2852148
    TMEM86B [Q8N661]3EBI-724754,EBI-2548832
    TMX2 [Q9Y320]3EBI-724754,EBI-6447886
    TSPAN12 [O95859]3EBI-724754,EBI-2466403
    TSPAN2 [O60636]3EBI-724754,EBI-3914288
    TSPAN33 [Q86UF1]3EBI-724754,EBI-12045841
    TTMP [Q5BVD1]3EBI-724754,EBI-10243654
    UBIAD1 [Q9Y5Z9]3EBI-724754,EBI-2819725
    UNC50 [Q53HI1]3EBI-724754,EBI-7601760
    VAMP3 [Q15836]3EBI-724754,EBI-722343
    VAMP4 [O75379]3EBI-724754,EBI-744953
    YIF1A [O95070]3EBI-724754,EBI-2799703
    ZFPL1 [O95159]3EBI-724754,EBI-718439

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    110415, 137 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    O14880, 394 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000356864

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    O14880 protein

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the MAPEG family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    ENOG410J29S Eukaryota
    ENOG4111URX LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00390000008608

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_110291_1_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    O14880

    KEGG Orthology (KO)

    More...
    KOi
    K00799

    Database of Orthologous Groups

    More...
    OrthoDBi
    1609516at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    O14880

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF105328

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.20.120.550, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR023352 MAPEG-like_dom_sf
    IPR001129 Membr-assoc_MAPEG

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01124 MAPEG, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF161084 SSF161084, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

    O14880-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MAVLSKEYGF VLLTGAASFI MVAHLAINVS KARKKYKVEY PIMYSTDPEN
    60 70 80 90 100
    GHIFNCIQRA HQNTLEVYPP FLFFLAVGGV YHPRIASGLG LAWIVGRVLY
    110 120 130 140 150
    AYGYYTGEPS KRSRGALGSI ALLGLVGTTV CSAFQHLGWV KSGLGSGPKC

    CH
    Length:152
    Mass (Da):16,516
    Last modified:January 1, 1998 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB721527247415E78
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    Q5VV87Q5VV87_HUMAN
    Microsomal glutathione S-transferas...
    MGST3
    129Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    Q5VV89Q5VV89_HUMAN
    Microsomal glutathione S-transferas...
    MGST3
    166Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01206115G → C. Corresponds to variant dbSNP:rs1802087Ensembl.1
    Natural variantiVAR_01206248P → S. Corresponds to variant dbSNP:rs1802088Ensembl.1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF026977 mRNA Translation: AAB82609.1
    CR450359 mRNA Translation: CAG29355.1
    AY388493 Genomic DNA Translation: AAQ81301.1
    AK312103 mRNA Translation: BAG35039.1
    AL451074 Genomic DNA No translation available.
    CH471067 Genomic DNA Translation: EAW90752.1
    BC000505 mRNA Translation: AAH00505.1
    BC003034 mRNA Translation: AAH03034.1
    BC005964 mRNA Translation: AAH05964.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS1249.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_004519.1, NM_004528.3
    XP_005245231.2, XM_005245174.3

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000367884; ENSP00000356859; ENSG00000143198
    ENST00000367889; ENSP00000356864; ENSG00000143198

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    4259

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:4259

    UCSC genome browser

    More...
    UCSCi
    uc001gdf.4 human

    Keywords - Coding sequence diversityi

    Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    <p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF026977 mRNA Translation: AAB82609.1
    CR450359 mRNA Translation: CAG29355.1
    AY388493 Genomic DNA Translation: AAQ81301.1
    AK312103 mRNA Translation: BAG35039.1
    AL451074 Genomic DNA No translation available.
    CH471067 Genomic DNA Translation: EAW90752.1
    BC000505 mRNA Translation: AAH00505.1
    BC003034 mRNA Translation: AAH03034.1
    BC005964 mRNA Translation: AAH05964.1
    CCDSiCCDS1249.1
    RefSeqiNP_004519.1, NM_004528.3
    XP_005245231.2, XM_005245174.3

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    BioGRIDi110415, 137 interactors
    IntActiO14880, 394 interactors
    STRINGi9606.ENSP00000356864

    Chemistry databases

    ChEMBLiCHEMBL1743186
    DrugBankiDB00143 Glutathione
    SwissLipidsiSLP:000001463

    PTM databases

    CarbonylDBiO14880
    iPTMnetiO14880
    PhosphoSitePlusiO14880
    SwissPalmiO14880

    Polymorphism and mutation databases

    BioMutaiMGST3

    Proteomic databases

    EPDiO14880
    jPOSTiO14880
    MassIVEiO14880
    MaxQBiO14880
    PaxDbiO14880
    PeptideAtlasiO14880
    PRIDEiO14880
    ProteomicsDBi48280
    TopDownProteomicsiO14880

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    34331 116 antibodies

    The DNASU plasmid repository

    More...
    DNASUi
    4259

    Genome annotation databases

    EnsembliENST00000367884; ENSP00000356859; ENSG00000143198
    ENST00000367889; ENSP00000356864; ENSG00000143198
    GeneIDi4259
    KEGGihsa:4259
    UCSCiuc001gdf.4 human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    4259
    DisGeNETi4259
    EuPathDBiHostDB:ENSG00000143198.12

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    MGST3
    HGNCiHGNC:7064 MGST3
    HPAiENSG00000143198 Low tissue specificity
    MIMi604564 gene
    neXtProtiNX_O14880
    OpenTargetsiENSG00000143198
    PharmGKBiPA30793

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiENOG410J29S Eukaryota
    ENOG4111URX LUCA
    GeneTreeiENSGT00390000008608
    HOGENOMiCLU_110291_1_0_1
    InParanoidiO14880
    KOiK00799
    OrthoDBi1609516at2759
    PhylomeDBiO14880
    TreeFamiTF105328

    Enzyme and pathway databases

    ReactomeiR-HSA-156590 Glutathione conjugation
    R-HSA-5423646 Aflatoxin activation and detoxification

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    4259 3 hits in 791 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    MGST3 human

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    MGST3

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    4259
    PharosiO14880 Tbio

    Protein Ontology

    More...
    PROi
    PR:O14880
    RNActiO14880 protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000143198 Expressed in corpus epididymis and 232 other tissues
    ExpressionAtlasiO14880 baseline and differential
    GenevisibleiO14880 HS

    Family and domain databases

    Gene3Di1.20.120.550, 1 hit
    InterProiView protein in InterPro
    IPR023352 MAPEG-like_dom_sf
    IPR001129 Membr-assoc_MAPEG
    PfamiView protein in Pfam
    PF01124 MAPEG, 1 hit
    SUPFAMiSSF161084 SSF161084, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMGST3_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O14880
    Secondary accession number(s): B2R592, Q6ICN4
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 1, 1998
    Last modified: June 17, 2020
    This is version 175 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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