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Protein

Microsomal glutathione S-transferase 3

Gene

MGST3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Also functions as a glutathione peroxidase.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

  • glutathione peroxidase activity Source: BHF-UCL
  • glutathione transferase activity Source: GO_Central
  • leukotriene-C4 synthase activity Source: BHF-UCL

GO - Biological processi

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

ReactomeiR-HSA-156590 Glutathione conjugation
R-HSA-5423646 Aflatoxin activation and detoxification

Chemistry databases

SwissLipidsiSLP:000001463

Names & Taxonomyi

Protein namesi
Recommended name:
Microsomal glutathione S-transferase 3 (EC:2.5.1.18)
Short name:
Microsomal GST-3
Alternative name(s):
Microsomal GST-III
Gene namesi
Name:MGST3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143198.12
HGNCiHGNC:7064 MGST3
MIMi604564 gene
neXtProtiNX_O14880

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Transmembranei71 – 91HelicalSequence analysisAdd BLAST21
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi150C → S: Abolishes S-acylation; when associated with S-151. 1 Publication1
Mutagenesisi151C → S: Abolishes S-acylation; when associated with S-150. 1 Publication1

Organism-specific databases

DisGeNETi4259
OpenTargetsiENSG00000143198
PharmGKBiPA30793

Chemistry databases

ChEMBLiCHEMBL1743186
DrugBankiDB00143 Glutathione

Polymorphism and mutation databases

BioMutaiMGST3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002177411 – 152Microsomal glutathione S-transferase 3Add BLAST152

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi150S-palmitoyl cysteine1 Publication1
Lipidationi151S-palmitoyl cysteine1 Publication1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

EPDiO14880
MaxQBiO14880
PaxDbiO14880
PeptideAtlasiO14880
PRIDEiO14880
ProteomicsDBi48280
TopDownProteomicsiO14880

PTM databases

CarbonylDBiO14880
iPTMnetiO14880
PhosphoSitePlusiO14880
SwissPalmiO14880

Expressioni

Tissue specificityi

Predominantly expressed in heart, skeletal muscle, and adrenal cortex. Also found in brain, placenta, liver, kidney, pancreas, thyroid, testis and ovary. Almost absent in lung, thymus and peripheral blood leukocytes.

Gene expression databases

BgeeiENSG00000143198 Expressed in 233 organ(s), highest expression level in corpus epididymis
CleanExiHS_MGST3
ExpressionAtlasiO14880 baseline and differential
GenevisibleiO14880 HS

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi110415, 31 interactors
IntActiO14880, 370 interactors
STRINGi9606.ENSP00000356859

Structurei

3D structure databases

ProteinModelPortaliO14880
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MAPEG family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J29S Eukaryota
ENOG4111URX LUCA
GeneTreeiENSGT00390000008608
HOGENOMiHOG000116372
HOVERGENiHBG052472
InParanoidiO14880
KOiK00799
PhylomeDBiO14880
TreeFamiTF105328

Family and domain databases

Gene3Di1.20.120.550, 1 hit
InterProiView protein in InterPro
IPR023352 MAPEG-like_dom_sf
IPR001129 Membr-assoc_MAPEG
PfamiView protein in Pfam
PF01124 MAPEG, 1 hit
SUPFAMiSSF161084 SSF161084, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O14880-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVLSKEYGF VLLTGAASFI MVAHLAINVS KARKKYKVEY PIMYSTDPEN
60 70 80 90 100
GHIFNCIQRA HQNTLEVYPP FLFFLAVGGV YHPRIASGLG LAWIVGRVLY
110 120 130 140 150
AYGYYTGEPS KRSRGALGSI ALLGLVGTTV CSAFQHLGWV KSGLGSGPKC

CH
Length:152
Mass (Da):16,516
Last modified:January 1, 1998 - v1
Checksum:iB721527247415E78
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5VV87Q5VV87_HUMAN
Microsomal glutathione S-transferas...
MGST3
129Annotation score:
Q5VV89Q5VV89_HUMAN
Microsomal glutathione S-transferas...
MGST3
166Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01206115G → C. Corresponds to variant dbSNP:rs1802087Ensembl.1
Natural variantiVAR_01206248P → S. Corresponds to variant dbSNP:rs1802088Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026977 mRNA Translation: AAB82609.1
CR450359 mRNA Translation: CAG29355.1
AY388493 Genomic DNA Translation: AAQ81301.1
AK312103 mRNA Translation: BAG35039.1
AL451074 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90752.1
BC000505 mRNA Translation: AAH00505.1
BC003034 mRNA Translation: AAH03034.1
BC005964 mRNA Translation: AAH05964.1
CCDSiCCDS1249.1
RefSeqiNP_004519.1, NM_004528.3
XP_005245231.2, XM_005245174.3
UniGeneiHs.191734
Hs.732686

Genome annotation databases

EnsembliENST00000367884; ENSP00000356859; ENSG00000143198
ENST00000367889; ENSP00000356864; ENSG00000143198
GeneIDi4259
KEGGihsa:4259
UCSCiuc001gdf.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026977 mRNA Translation: AAB82609.1
CR450359 mRNA Translation: CAG29355.1
AY388493 Genomic DNA Translation: AAQ81301.1
AK312103 mRNA Translation: BAG35039.1
AL451074 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90752.1
BC000505 mRNA Translation: AAH00505.1
BC003034 mRNA Translation: AAH03034.1
BC005964 mRNA Translation: AAH05964.1
CCDSiCCDS1249.1
RefSeqiNP_004519.1, NM_004528.3
XP_005245231.2, XM_005245174.3
UniGeneiHs.191734
Hs.732686

3D structure databases

ProteinModelPortaliO14880
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110415, 31 interactors
IntActiO14880, 370 interactors
STRINGi9606.ENSP00000356859

Chemistry databases

ChEMBLiCHEMBL1743186
DrugBankiDB00143 Glutathione
SwissLipidsiSLP:000001463

PTM databases

CarbonylDBiO14880
iPTMnetiO14880
PhosphoSitePlusiO14880
SwissPalmiO14880

Polymorphism and mutation databases

BioMutaiMGST3

Proteomic databases

EPDiO14880
MaxQBiO14880
PaxDbiO14880
PeptideAtlasiO14880
PRIDEiO14880
ProteomicsDBi48280
TopDownProteomicsiO14880

Protocols and materials databases

DNASUi4259
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367884; ENSP00000356859; ENSG00000143198
ENST00000367889; ENSP00000356864; ENSG00000143198
GeneIDi4259
KEGGihsa:4259
UCSCiuc001gdf.4 human

Organism-specific databases

CTDi4259
DisGeNETi4259
EuPathDBiHostDB:ENSG00000143198.12
GeneCardsiMGST3
HGNCiHGNC:7064 MGST3
MIMi604564 gene
neXtProtiNX_O14880
OpenTargetsiENSG00000143198
PharmGKBiPA30793
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J29S Eukaryota
ENOG4111URX LUCA
GeneTreeiENSGT00390000008608
HOGENOMiHOG000116372
HOVERGENiHBG052472
InParanoidiO14880
KOiK00799
PhylomeDBiO14880
TreeFamiTF105328

Enzyme and pathway databases

ReactomeiR-HSA-156590 Glutathione conjugation
R-HSA-5423646 Aflatoxin activation and detoxification

Miscellaneous databases

ChiTaRSiMGST3 human
GeneWikiiMGST3
GenomeRNAii4259
PROiPR:O14880
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143198 Expressed in 233 organ(s), highest expression level in corpus epididymis
CleanExiHS_MGST3
ExpressionAtlasiO14880 baseline and differential
GenevisibleiO14880 HS

Family and domain databases

Gene3Di1.20.120.550, 1 hit
InterProiView protein in InterPro
IPR023352 MAPEG-like_dom_sf
IPR001129 Membr-assoc_MAPEG
PfamiView protein in Pfam
PF01124 MAPEG, 1 hit
SUPFAMiSSF161084 SSF161084, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMGST3_HUMAN
AccessioniPrimary (citable) accession number: O14880
Secondary accession number(s): B2R592, Q6ICN4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 164 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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