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UniProtKB - O14867 (BACH1_HUMAN)
Protein
Transcription regulator protein BACH1
Gene
BACH1
Organism
Homo sapiens (Human)
Status
Functioni
Transcriptional regulator that acts as repressor or activator, depending on the context. Binds to NF-E2 DNA binding sites. Plays important roles in coordinating transcription activation and repression by MAFK (By similarity).
Together with MAF, represses the transcription of genes under the control of the NFE2L2 oxidative stress pathway (PubMed:24035498).
By similarity1 PublicationGO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: UniProtKB
- heme binding Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- DNA repair Source: CACAO
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of transcription from RNA polymerase II promoter in response to hypoxia Source: UniProtKB
- regulation of transcription involved in G1/S transition of mitotic cell cycle Source: UniProtKB
- regulation of transcription involved in G2/M transition of mitotic cell cycle Source: UniProtKB
Keywordsi
Molecular function | Activator, DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
BRENDAi | 3.6.4.12, 2681 |
PathwayCommonsi | O14867 |
Reactomei | R-HSA-9707587, Regulation of HMOX1 expression and activity R-HSA-9707616, Heme signaling R-HSA-9708530, Regulation of BACH1 activity |
SignaLinki | O14867 |
SIGNORi | O14867 |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription regulator protein BACH1CuratedAlternative name(s): BTB and CNC homolog 11 Publication HA2303 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:935, BACH1 |
MIMi | 602751, gene |
neXtProti | NX_O14867 |
VEuPathDBi | HostDB:ENSG00000156273 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation1 Publication
Cytosol
- cytosol Source: Reactome
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
- RNA polymerase II transcription regulator complex Source: ComplexPortal
Other locations
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 571 |
OpenTargetsi | ENSG00000156273 |
PharmGKBi | PA25234 |
Miscellaneous databases
Pharosi | O14867, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4295651 |
Genetic variation databases
BioMutai | BACH1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076454 | 1 – 736 | Transcription regulator protein BACH1Add BLAST | 736 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 196 | PhosphoserineCombined sources | 1 | |
Modified residuei | 364 | PhosphoserineCombined sources | 1 | |
Modified residuei | 445 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Ubiquitinated by the SCF(FBXL17) complex, leading to its degradation by the proteasome.1 Publication
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
EPDi | O14867 |
jPOSTi | O14867 |
MassIVEi | O14867 |
PaxDbi | O14867 |
PeptideAtlasi | O14867 |
PRIDEi | O14867 |
ProteomicsDBi | 48277 |
PTM databases
iPTMneti | O14867 |
PhosphoSitePlusi | O14867 |
Expressioni
Gene expression databases
Bgeei | ENSG00000156273, Expressed in secondary oocyte and 225 other tissues |
ExpressionAtlasi | O14867, baseline and differential |
Genevisiblei | O14867, HS |
Organism-specific databases
HPAi | ENSG00000156273, Tissue enhanced (bone) |
Interactioni
Subunit structurei
Heterodimer of BACH1 and MAFK.
By similarityBinary interactionsi
O14867
Protein-protein interaction databases
BioGRIDi | 107047, 87 interactors |
ComplexPortali | CPX-6402, bZIP transcription factor complex, ATF1-BACH1 CPX-6412, bZIP transcription factor complex, ATF2-BACH1 CPX-6781, bZIP transcription factor complex, ATF7-BACH1 CPX-7012, bZIP transcription factor complex, BACH1-BATF |
CORUMi | O14867 |
DIPi | DIP-24223N |
IntActi | O14867, 49 interactors |
MINTi | O14867 |
STRINGi | 9606.ENSP00000382805 |
Miscellaneous databases
RNActi | O14867, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | O14867 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O14867 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 34 – 100 | BTBPROSITE-ProRule annotationAdd BLAST | 67 | |
Domaini | 557 – 620 | bZIPPROSITE-ProRule annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 286 – 312 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 349 – 389 | DisorderedSequence analysisAdd BLAST | 41 | |
Regioni | 562 – 578 | Basic motifPROSITE-ProRule annotationAdd BLAST | 17 | |
Regioni | 582 – 589 | Leucine-zipperPROSITE-ProRule annotation | 8 | |
Regioni | 680 – 719 | DisorderedSequence analysisAdd BLAST | 40 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 692 – 719 | Polar residuesSequence analysisAdd BLAST | 28 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3863, Eukaryota |
GeneTreei | ENSGT00940000158923 |
HOGENOMi | CLU_015243_2_0_1 |
InParanoidi | O14867 |
OMAi | RKKCFPS |
OrthoDBi | 521871at2759 |
PhylomeDBi | O14867 |
TreeFami | TF326681 |
Family and domain databases
CDDi | cd14719, bZIP_BACH, 1 hit |
Gene3Di | 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR004827, bZIP IPR043321, bZIP_BACH IPR004826, bZIP_Maf IPR011333, SKP1/BTB/POZ_sf IPR008917, TF_DNA-bd_sf |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF03131, bZIP_Maf, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit SM00225, BTB, 1 hit |
SUPFAMi | SSF47454, SSF47454, 1 hit SSF54695, SSF54695, 1 hit |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
O14867-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLSENSVFA YESSVHSTNV LLSLNDQRKK DVLCDVTIFV EGQRFRAHRS
60 70 80 90 100
VLAACSSYFH SRIVGQADGE LNITLPEEVT VKGFEPLIQF AYTAKLILSK
110 120 130 140 150
ENVDEVCKCV EFLSVHNIEE SCFQFLKFKF LDSTADQQEC PRKKCFSSHC
160 170 180 190 200
QKTDLKLSLL DQRDLETDEV EEFLENKNVQ TPQCKLRRYQ GNAKASPPLQ
210 220 230 240 250
DSASQTYESM CLEKDAALAL PSLCPKYRKF QKAFGTDRVR TGESSVKDIH
260 270 280 290 300
ASVQPNERSE NECLGGVPEC RDLQVMLKCD ESKLAMEPEE TKKDPASQCP
310 320 330 340 350
TEKSEVTPFP HNSSIDPHGL YSLSLLHTYD QYGDLNFAGM QNTTVLTEKP
360 370 380 390 400
LSGTDVQEKT FGESQDLPLK SDLGTREDSS VASSDRSSVE REVAEHLAKG
410 420 430 440 450
FWSDICSTDT PCQMQLSPAV AKDGSEQISQ KRSECPWLGI RISESPEPGQ
460 470 480 490 500
RTFTTLSSVN CPFISTLSTE GCSSNLEIGN DDYVSEPQQE PCPYACVISL
510 520 530 540 550
GDDSETDTEG DSESCSAREQ ECEVKLPFNA QRIISLSRND FQSLLKMHKL
560 570 580 590 600
TPEQLDCIHD IRRRSKNRIA AQRCRKRKLD CIQNLESEIE KLQSEKESLL
610 620 630 640 650
KERDHILSTL GETKQNLTGL CQKVCKEAAL SQEQIQILAK YSAADCPLSF
660 670 680 690 700
LISEKDKSTP DGELALPSIF SLSDRPPAVL PPCARGNSEP GYARGQESQQ
710 720 730
MSTATSEQAG PAEQCRQSGG ISDFCQQMTD KCTTDE
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7C4B6 | H7C4B6_HUMAN | Transcription regulator protein BAC... | BACH1 | 218 | Annotation score: | ||
M0QZP0 | M0QZP0_HUMAN | Transcription regulator protein BAC... | BACH1 | 138 | Annotation score: | ||
C9IYH8 | C9IYH8_HUMAN | Transcription regulator protein BAC... | BACH1 | 170 | Annotation score: | ||
C9JMP6 | C9JMP6_HUMAN | Transcription regulator protein BAC... | BACH1 | 220 | Annotation score: | ||
C9IYR0 | C9IYR0_HUMAN | Transcription regulator protein BAC... | BACH1 | 224 | Annotation score: | ||
F8VZL7 | F8VZL7_HUMAN | Transcription regulator protein BAC... | BACH1 | 25 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 158 | S → T in AAB84100 (PubMed:9544839).Curated | 1 | |
Sequence conflicti | 171 | E → G in AAB84100 (PubMed:9544839).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_048441 | 314 | S → P. Corresponds to variant dbSNP:rs35474725Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF026199 mRNA Translation: AAB84100.1 AF026200 mRNA Translation: AAB84101.1 AB002803 mRNA Translation: BAA24932.1 AF124731 Genomic DNA Translation: AAD14689.1 AK313791 mRNA Translation: BAG36528.1 CR450303 mRNA Translation: CAG29299.1 AL163249 Genomic DNA Translation: CAB90435.1 AP001705 Genomic DNA Translation: BAA95505.1 CH471079 Genomic DNA Translation: EAX09913.1 BC063307 mRNA Translation: AAH63307.1 |
CCDSi | CCDS13585.1 |
PIRi | T00023 |
RefSeqi | NP_001177.1, NM_001186.3 NP_996749.1, NM_206866.2 |
Genome annotation databases
Ensembli | ENST00000286800; ENSP00000286800; ENSG00000156273 ENST00000399921; ENSP00000382805; ENSG00000156273 |
GeneIDi | 571 |
KEGGi | hsa:571 |
MANE-Selecti | ENST00000286800.8; ENSP00000286800.3; NM_001186.4; NP_001177.1 |
UCSCi | uc002ynj.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF026199 mRNA Translation: AAB84100.1 AF026200 mRNA Translation: AAB84101.1 AB002803 mRNA Translation: BAA24932.1 AF124731 Genomic DNA Translation: AAD14689.1 AK313791 mRNA Translation: BAG36528.1 CR450303 mRNA Translation: CAG29299.1 AL163249 Genomic DNA Translation: CAB90435.1 AP001705 Genomic DNA Translation: BAA95505.1 CH471079 Genomic DNA Translation: EAX09913.1 BC063307 mRNA Translation: AAH63307.1 |
CCDSi | CCDS13585.1 |
PIRi | T00023 |
RefSeqi | NP_001177.1, NM_001186.3 NP_996749.1, NM_206866.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2IHC | X-ray | 2.44 | A/B/C/D | 7-128 | [»] | |
SMRi | O14867 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107047, 87 interactors |
ComplexPortali | CPX-6402, bZIP transcription factor complex, ATF1-BACH1 CPX-6412, bZIP transcription factor complex, ATF2-BACH1 CPX-6781, bZIP transcription factor complex, ATF7-BACH1 CPX-7012, bZIP transcription factor complex, BACH1-BATF |
CORUMi | O14867 |
DIPi | DIP-24223N |
IntActi | O14867, 49 interactors |
MINTi | O14867 |
STRINGi | 9606.ENSP00000382805 |
Chemistry databases
ChEMBLi | CHEMBL4295651 |
PTM databases
iPTMneti | O14867 |
PhosphoSitePlusi | O14867 |
Genetic variation databases
BioMutai | BACH1 |
Proteomic databases
EPDi | O14867 |
jPOSTi | O14867 |
MassIVEi | O14867 |
PaxDbi | O14867 |
PeptideAtlasi | O14867 |
PRIDEi | O14867 |
ProteomicsDBi | 48277 |
Protocols and materials databases
Antibodypediai | 920, 375 antibodies from 38 providers |
DNASUi | 571 |
Genome annotation databases
Ensembli | ENST00000286800; ENSP00000286800; ENSG00000156273 ENST00000399921; ENSP00000382805; ENSG00000156273 |
GeneIDi | 571 |
KEGGi | hsa:571 |
MANE-Selecti | ENST00000286800.8; ENSP00000286800.3; NM_001186.4; NP_001177.1 |
UCSCi | uc002ynj.4, human |
Organism-specific databases
CTDi | 571 |
DisGeNETi | 571 |
GeneCardsi | BACH1 |
HGNCi | HGNC:935, BACH1 |
HPAi | ENSG00000156273, Tissue enhanced (bone) |
MIMi | 602751, gene |
neXtProti | NX_O14867 |
OpenTargetsi | ENSG00000156273 |
PharmGKBi | PA25234 |
VEuPathDBi | HostDB:ENSG00000156273 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3863, Eukaryota |
GeneTreei | ENSGT00940000158923 |
HOGENOMi | CLU_015243_2_0_1 |
InParanoidi | O14867 |
OMAi | RKKCFPS |
OrthoDBi | 521871at2759 |
PhylomeDBi | O14867 |
TreeFami | TF326681 |
Enzyme and pathway databases
BRENDAi | 3.6.4.12, 2681 |
PathwayCommonsi | O14867 |
Reactomei | R-HSA-9707587, Regulation of HMOX1 expression and activity R-HSA-9707616, Heme signaling R-HSA-9708530, Regulation of BACH1 activity |
SignaLinki | O14867 |
SIGNORi | O14867 |
Miscellaneous databases
BioGRID-ORCSi | 571, 8 hits in 1103 CRISPR screens |
ChiTaRSi | BACH1, human |
EvolutionaryTracei | O14867 |
GeneWikii | BACH1 |
GenomeRNAii | 571 |
Pharosi | O14867, Tbio |
PROi | PR:O14867 |
RNActi | O14867, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000156273, Expressed in secondary oocyte and 225 other tissues |
ExpressionAtlasi | O14867, baseline and differential |
Genevisiblei | O14867, HS |
Family and domain databases
CDDi | cd14719, bZIP_BACH, 1 hit |
Gene3Di | 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR004827, bZIP IPR043321, bZIP_BACH IPR004826, bZIP_Maf IPR011333, SKP1/BTB/POZ_sf IPR008917, TF_DNA-bd_sf |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF03131, bZIP_Maf, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit SM00225, BTB, 1 hit |
SUPFAMi | SSF47454, SSF47454, 1 hit SSF54695, SSF54695, 1 hit |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | BACH1_HUMAN | |
Accessioni | O14867Primary (citable) accession number: O14867 Secondary accession number(s): O43285, Q6ICU0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | May 30, 2000 | |
Last modified: | February 23, 2022 | |
This is version 201 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 21
Human chromosome 21: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families