Transcription regulator protein BACH1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
• DNA-binding transcription factor activity Source: UniProtKB
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells."
    Kitamuro T., Takahashi K., Ogawa K., Udono-Fujimori R., Takeda K., Furuyama K., Nakayama M., Sun J., Fujita H., Hida W., Hattori T., Shirato K., Igarashi K., Shibahara S.
    J. Biol. Chem. 278:9125-9133(2003) [PubMed] [Europe PMC] [Abstract]
  • Ref.12

    "Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover."
    Tan M.K., Lim H.J., Bennett E.J., Shi Y., Harper J.W.
    Mol. Cell 52:9-24(2013) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBCELLULAR LOCATION, UBIQUITINATION.
• heme binding Source: UniProtKB <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • "The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle."
    Warnatz H.J., Schmidt D., Manke T., Piccini I., Sultan M., Borodina T., Balzereit D., Wruck W., Soldatov A., Vingron M., Lehrach H., Yaspo M.L.
    J. Biol. Chem. 286:23521-23532(2011) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl

GO - Biological processⁱ

• DNA repair Source: CACAO <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function."
    Cantor S.B., Bell D.W., Ganesan S., Kass E.M., Drapkin R., Grossman S., Wahrer D.C.R., Sgroi D.C., Lane W.S., Haber D.A., Livingston D.M.
    Cell 105:149-160(2001) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: UniProtKBInferred from direct assayⁱ
  • Ref.12

    "Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover."
    Tan M.K., Lim H.J., Bennett E.J., Shi Y., Harper J.W.
    Mol. Cell 52:9-24(2013) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBCELLULAR LOCATION, UBIQUITINATION.
• regulation of transcription, DNA-templated Source: UniProtKB
• regulation of transcription from RNA polymerase II promoter in response to hypoxia Source: UniProtKBInferred from direct assayⁱ
  • "Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells."
    Kitamuro T., Takahashi K., Ogawa K., Udono-Fujimori R., Takeda K., Furuyama K., Nakayama M., Sun J., Fujita H., Hida W., Hattori T., Shirato K., Igarashi K., Shibahara S.
    J. Biol. Chem. 278:9125-9133(2003) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription involved in G1/S transition of mitotic cell cycle Source: UniProtKBInferred from mutant phenotypeⁱ
  • "The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle."
    Warnatz H.J., Schmidt D., Manke T., Piccini I., Sultan M., Borodina T., Balzereit D., Wruck W., Soldatov A., Vingron M., Lehrach H., Yaspo M.L.
    J. Biol. Chem. 286:23521-23532(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription involved in G2/M transition of mitotic cell cycle Source: UniProtKBInferred from mutant phenotypeⁱ
  • "The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle."
    Warnatz H.J., Schmidt D., Manke T., Piccini I., Sultan M., Borodina T., Balzereit D., Wruck W., Soldatov A., Vingron M., Lehrach H., Yaspo M.L.
    J. Biol. Chem. 286:23521-23532(2011) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Miscellaneous databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MSLSENSVFA YESSVHSTNV LLSLNDQRKK DVLCDVTIFV EGQRFRAHRS 
        60         70         80         90        100
VLAACSSYFH SRIVGQADGE LNITLPEEVT VKGFEPLIQF AYTAKLILSK 
       110        120        130        140        150
ENVDEVCKCV EFLSVHNIEE SCFQFLKFKF LDSTADQQEC PRKKCFSSHC 
       160        170        180        190        200
QKTDLKLSLL DQRDLETDEV EEFLENKNVQ TPQCKLRRYQ GNAKASPPLQ 
       210        220        230        240        250
DSASQTYESM CLEKDAALAL PSLCPKYRKF QKAFGTDRVR TGESSVKDIH 
       260        270        280        290        300
ASVQPNERSE NECLGGVPEC RDLQVMLKCD ESKLAMEPEE TKKDPASQCP 
       310        320        330        340        350
TEKSEVTPFP HNSSIDPHGL YSLSLLHTYD QYGDLNFAGM QNTTVLTEKP 
       360        370        380        390        400
LSGTDVQEKT FGESQDLPLK SDLGTREDSS VASSDRSSVE REVAEHLAKG 
       410        420        430        440        450
FWSDICSTDT PCQMQLSPAV AKDGSEQISQ KRSECPWLGI RISESPEPGQ 
       460        470        480        490        500
RTFTTLSSVN CPFISTLSTE GCSSNLEIGN DDYVSEPQQE PCPYACVISL 
       510        520        530        540        550
GDDSETDTEG DSESCSAREQ ECEVKLPFNA QRIISLSRND FQSLLKMHKL 
       560        570        580        590        600
TPEQLDCIHD IRRRSKNRIA AQRCRKRKLD CIQNLESEIE KLQSEKESLL 
       610        620        630        640        650
KERDHILSTL GETKQNLTGL CQKVCKEAAL SQEQIQILAK YSAADCPLSF 
       660        670        680        690        700
LISEKDKSTP DGELALPSIF SLSDRPPAVL PPCARGNSEP GYARGQESQQ 
       710        720        730 
MSTATSEQAG PAEQCRQSGG ISDFCQQMTD KCTTDE                

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
2. SIMILARITY comments
   Index of protein domains and families
3. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations
4. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations
5. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
6. Human chromosome 21
   Human chromosome 21: entries, gene names and cross-references to MIM