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Protein

Transcription regulator protein BACH1

Gene

BACH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional regulator that acts as repressor or activator. Binds, in vitro, to NF-E2 binding sites. Play important roles in coordinating transcription activation and repression by MAFK.

GO - Molecular functioni

GO - Biological processi

  • DNA repair Source: CACAO
  • negative regulation of transcription by RNA polymerase II Source: UniProtKB
  • protein ubiquitination Source: GOC
  • regulation of transcription, DNA-templated Source: UniProtKB
  • regulation of transcription from RNA polymerase II promoter in response to hypoxia Source: UniProtKB
  • regulation of transcription involved in G1/S transition of mitotic cell cycle Source: UniProtKB
  • regulation of transcription involved in G2/M transition of mitotic cell cycle Source: UniProtKB

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BRENDAi3.6.4.12 2681
SIGNORiO14867

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription regulator protein BACH1
Alternative name(s):
BTB and CNC homolog 1
HA2303
Gene namesi
Name:BACH1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000156273.15
HGNCiHGNC:935 BACH1
MIMi602751 gene
neXtProtiNX_O14867

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi571
OpenTargetsiENSG00000156273
PharmGKBiPA25234

Polymorphism and mutation databases

BioMutaiBACH1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000764541 – 736Transcription regulator protein BACH1Add BLAST736

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei196PhosphoserineCombined sources1
Modified residuei364PhosphoserineCombined sources1
Modified residuei445PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO14867
PaxDbiO14867
PeptideAtlasiO14867
PRIDEiO14867
ProteomicsDBi48277

PTM databases

iPTMnetiO14867
PhosphoSitePlusiO14867

Expressioni

Gene expression databases

BgeeiENSG00000156273
CleanExiHS_BACH1
ExpressionAtlasiO14867 baseline and differential
GenevisibleiO14867 HS

Organism-specific databases

HPAiHPA034949

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi107047, 62 interactors
CORUMiO14867
DIPiDIP-24223N
IntActiO14867, 30 interactors
MINTiO14867
STRINGi9606.ENSP00000286800

Structurei

Secondary structure

1736
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 12Combined sources5
Helixi16 – 30Combined sources15
Beta strandi36 – 40Combined sources5
Beta strandi43 – 47Combined sources5
Helixi49 – 55Combined sources7
Helixi57 – 63Combined sources7
Beta strandi71 – 74Combined sources4
Helixi81 – 93Combined sources13
Beta strandi94 – 99Combined sources6
Turni100 – 102Combined sources3
Helixi103 – 113Combined sources11
Beta strandi115 – 117Combined sources3
Helixi120 – 124Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IHCX-ray2.44A/B/C/D7-128[»]
ProteinModelPortaliO14867
SMRiO14867
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO14867

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 100BTBPROSITE-ProRule annotationAdd BLAST67
Domaini557 – 620bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni562 – 578Basic motifPROSITE-ProRule annotationAdd BLAST17
Regioni582 – 589Leucine-zipperPROSITE-ProRule annotation8

Sequence similaritiesi

Belongs to the bZIP family. CNC subfamily.Curated

Phylogenomic databases

eggNOGiENOG410ISV2 Eukaryota
ENOG410Z743 LUCA
GeneTreeiENSGT00920000148991
HOGENOMiHOG000231712
HOVERGENiHBG099852
InParanoidiO14867
KOiK09042
OMAiCQMQLSP
OrthoDBiEOG091G02EB
PhylomeDBiO14867
TreeFamiTF326681

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR004827 bZIP
IPR004826 bZIP_Maf
IPR011333 SKP1/BTB/POZ_sf
IPR008917 TF_DNA-bd_sf
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF03131 bZIP_Maf, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
SM00225 BTB, 1 hit
SUPFAMiSSF47454 SSF47454, 1 hit
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit

Sequencei

Sequence statusi: Complete.

O14867-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSENSVFA YESSVHSTNV LLSLNDQRKK DVLCDVTIFV EGQRFRAHRS
60 70 80 90 100
VLAACSSYFH SRIVGQADGE LNITLPEEVT VKGFEPLIQF AYTAKLILSK
110 120 130 140 150
ENVDEVCKCV EFLSVHNIEE SCFQFLKFKF LDSTADQQEC PRKKCFSSHC
160 170 180 190 200
QKTDLKLSLL DQRDLETDEV EEFLENKNVQ TPQCKLRRYQ GNAKASPPLQ
210 220 230 240 250
DSASQTYESM CLEKDAALAL PSLCPKYRKF QKAFGTDRVR TGESSVKDIH
260 270 280 290 300
ASVQPNERSE NECLGGVPEC RDLQVMLKCD ESKLAMEPEE TKKDPASQCP
310 320 330 340 350
TEKSEVTPFP HNSSIDPHGL YSLSLLHTYD QYGDLNFAGM QNTTVLTEKP
360 370 380 390 400
LSGTDVQEKT FGESQDLPLK SDLGTREDSS VASSDRSSVE REVAEHLAKG
410 420 430 440 450
FWSDICSTDT PCQMQLSPAV AKDGSEQISQ KRSECPWLGI RISESPEPGQ
460 470 480 490 500
RTFTTLSSVN CPFISTLSTE GCSSNLEIGN DDYVSEPQQE PCPYACVISL
510 520 530 540 550
GDDSETDTEG DSESCSAREQ ECEVKLPFNA QRIISLSRND FQSLLKMHKL
560 570 580 590 600
TPEQLDCIHD IRRRSKNRIA AQRCRKRKLD CIQNLESEIE KLQSEKESLL
610 620 630 640 650
KERDHILSTL GETKQNLTGL CQKVCKEAAL SQEQIQILAK YSAADCPLSF
660 670 680 690 700
LISEKDKSTP DGELALPSIF SLSDRPPAVL PPCARGNSEP GYARGQESQQ
710 720 730
MSTATSEQAG PAEQCRQSGG ISDFCQQMTD KCTTDE
Length:736
Mass (Da):81,958
Last modified:May 30, 2000 - v2
Checksum:iCAAEECC63D46571B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti158S → T in AAB84100 (PubMed:9544839).Curated1
Sequence conflicti171E → G in AAB84100 (PubMed:9544839).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048441314S → P. Corresponds to variant dbSNP:rs35474725Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026199 mRNA Translation: AAB84100.1
AF026200 mRNA Translation: AAB84101.1
AB002803 mRNA Translation: BAA24932.1
AF124731 Genomic DNA Translation: AAD14689.1
AK313791 mRNA Translation: BAG36528.1
CR450303 mRNA Translation: CAG29299.1
AL163249 Genomic DNA Translation: CAB90435.1
AP001705 Genomic DNA Translation: BAA95505.1
CH471079 Genomic DNA Translation: EAX09913.1
BC063307 mRNA Translation: AAH63307.1
CCDSiCCDS13585.1
PIRiT00023
RefSeqiNP_001177.1, NM_001186.3
NP_996749.1, NM_206866.2
UniGeneiHs.154276

Genome annotation databases

EnsembliENST00000286800; ENSP00000286800; ENSG00000156273
ENST00000399921; ENSP00000382805; ENSG00000156273
GeneIDi571
KEGGihsa:571
UCSCiuc002ynj.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiBACH1_HUMAN
AccessioniPrimary (citable) accession number: O14867
Secondary accession number(s): O43285, Q6ICU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 30, 2000
Last modified: June 20, 2018
This is version 178 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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