Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc transporter 4

Gene

SLC30A4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably involved in zinc transport out of the cytoplasm, maybe by sequestration into an intracellular compartment.

GO - Molecular functioni

  • zinc ion transmembrane transporter activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processIon transport, Transport, Zinc transport
LigandZinc

Protein family/group databases

TCDBi2.A.4.3.7 the cation diffusion facilitator (cdf) family

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter 4
Short name:
ZnT-4
Alternative name(s):
Solute carrier family 30 member 4
Gene namesi
Name:SLC30A4
Synonyms:ZNT4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000104154.6
HGNCiHGNC:11015 SLC30A4
MIMi602095 gene
neXtProtiNX_O14863

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 113CytoplasmicSequence analysisAdd BLAST113
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Topological domaini135 – 143VacuolarSequence analysis9
Transmembranei144 – 164HelicalSequence analysisAdd BLAST21
Topological domaini165 – 178CytoplasmicSequence analysisAdd BLAST14
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Topological domaini200 – 216VacuolarSequence analysisAdd BLAST17
Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
Topological domaini238 – 274CytoplasmicSequence analysisAdd BLAST37
Transmembranei275 – 295HelicalSequence analysisAdd BLAST21
Topological domaini296 – 310VacuolarSequence analysisAdd BLAST15
Transmembranei311 – 331HelicalSequence analysisAdd BLAST21
Topological domaini332 – 429CytoplasmicSequence analysisAdd BLAST98

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi7782
OpenTargetsiENSG00000104154
PharmGKBiPA35885

Polymorphism and mutation databases

BioMutaiSLC30A4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002060991 – 429Zinc transporter 4Add BLAST429

Proteomic databases

MaxQBiO14863
PaxDbiO14863
PeptideAtlasiO14863
PRIDEiO14863
ProteomicsDBi48276

PTM databases

iPTMnetiO14863
PhosphoSitePlusiO14863

Expressioni

Gene expression databases

BgeeiENSG00000104154 Expressed in 204 organ(s), highest expression level in putamen
CleanExiHS_SLC30A4
GenevisibleiO14863 HS

Organism-specific databases

HPAiHPA018178

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi113563, 23 interactors
IntActiO14863, 20 interactors
STRINGi9606.ENSP00000261867

Structurei

3D structure databases

ProteinModelPortaliO14863
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi17 – 96Asp-rich (acidic)Add BLAST80
Compositional biasi241 – 247His-rich7

Domaini

Contains a histidine-rich region which is a ligand for zinc and an aspartate-rich region which is a potential ligand for zinc.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1482 Eukaryota
COG1230 LUCA
GeneTreeiENSGT00550000074381
HOGENOMiHOG000079023
HOVERGENiHBG003345
InParanoidiO14863
KOiK14691
OMAiELNVWAL
OrthoDBiEOG091G07UN
PhylomeDBiO14863
TreeFamiTF313382

Family and domain databases

Gene3Di1.20.1510.10, 1 hit
InterProiView protein in InterPro
IPR002524 Cation_efflux
IPR036837 Cation_efflux_CTD_sf
IPR027469 Cation_efflux_TMD_sf
PfamiView protein in Pfam
PF01545 Cation_efflux, 1 hit
SUPFAMiSSF160240 SSF160240, 1 hit
SSF161111 SSF161111, 1 hit
TIGRFAMsiTIGR01297 CDF, 1 hit

Sequencei

Sequence statusi: Complete.

O14863-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGSGAWKRL KSMLRKDDAP LFLNDTSAFD FSDEAGDEGL SRFNKLRVVV
60 70 80 90 100
ADDGSEAPER PVNGAHPTLQ ADDDSLLDQD LPLTNSQLSL KVDSCDNCSK
110 120 130 140 150
QREILKQRKV KARLTIAAVL YLLFMIGELV GGYIANSLAI MTDALHMLTD
160 170 180 190 200
LSAIILTLLA LWLSSKSPTK RFTFGFHRLE VLSAMISVLL VYILMGFLLY
210 220 230 240 250
EAVQRTIHMN YEINGDIMLI TAAVGVAVNV IMGFLLNQSG HRHSHSHSLP
260 270 280 290 300
SNSPTRGSGC ERNHGQDSLA VRAAFVHALG DLVQSVGVLI AAYIIRFKPE
310 320 330 340 350
YKIADPICTY VFSLLVAFTT FRIIWDTVVI ILEGVPSHLN VDYIKEALMK
360 370 380 390 400
IEDVYSVEDL NIWSLTSGKS TAIVHIQLIP GSSSKWEEVQ SKANHLLLNT
410 420
FGMYRCTIQL QSYRQEVDRT CANCQSSSP
Length:429
Mass (Da):47,483
Last modified:September 23, 2008 - v2
Checksum:i97B7FCBE881C8C32
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30D → E in AAB82561 (PubMed:9354792).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025409 mRNA Translation: AAB82561.1
AK290874 mRNA Translation: BAF83563.1
CH471082 Genomic DNA Translation: EAW77316.1
BC026089 mRNA Translation: AAH26089.1
CCDSiCCDS10125.1
RefSeqiNP_037441.2, NM_013309.5
XP_011520299.1, XM_011521997.2
XP_016878049.1, XM_017022560.1
UniGeneiHs.162989
Hs.375762

Genome annotation databases

EnsembliENST00000261867; ENSP00000261867; ENSG00000104154
GeneIDi7782
KEGGihsa:7782
UCSCiuc001zvj.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025409 mRNA Translation: AAB82561.1
AK290874 mRNA Translation: BAF83563.1
CH471082 Genomic DNA Translation: EAW77316.1
BC026089 mRNA Translation: AAH26089.1
CCDSiCCDS10125.1
RefSeqiNP_037441.2, NM_013309.5
XP_011520299.1, XM_011521997.2
XP_016878049.1, XM_017022560.1
UniGeneiHs.162989
Hs.375762

3D structure databases

ProteinModelPortaliO14863
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113563, 23 interactors
IntActiO14863, 20 interactors
STRINGi9606.ENSP00000261867

Protein family/group databases

TCDBi2.A.4.3.7 the cation diffusion facilitator (cdf) family

PTM databases

iPTMnetiO14863
PhosphoSitePlusiO14863

Polymorphism and mutation databases

BioMutaiSLC30A4

Proteomic databases

MaxQBiO14863
PaxDbiO14863
PeptideAtlasiO14863
PRIDEiO14863
ProteomicsDBi48276

Protocols and materials databases

DNASUi7782
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261867; ENSP00000261867; ENSG00000104154
GeneIDi7782
KEGGihsa:7782
UCSCiuc001zvj.5 human

Organism-specific databases

CTDi7782
DisGeNETi7782
EuPathDBiHostDB:ENSG00000104154.6
GeneCardsiSLC30A4
H-InvDBiHIX0012212
HGNCiHGNC:11015 SLC30A4
HPAiHPA018178
MIMi602095 gene
neXtProtiNX_O14863
OpenTargetsiENSG00000104154
PharmGKBiPA35885
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1482 Eukaryota
COG1230 LUCA
GeneTreeiENSGT00550000074381
HOGENOMiHOG000079023
HOVERGENiHBG003345
InParanoidiO14863
KOiK14691
OMAiELNVWAL
OrthoDBiEOG091G07UN
PhylomeDBiO14863
TreeFamiTF313382

Miscellaneous databases

ChiTaRSiSLC30A4 human
GeneWikiiSLC30A4
GenomeRNAii7782
PROiPR:O14863
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000104154 Expressed in 204 organ(s), highest expression level in putamen
CleanExiHS_SLC30A4
GenevisibleiO14863 HS

Family and domain databases

Gene3Di1.20.1510.10, 1 hit
InterProiView protein in InterPro
IPR002524 Cation_efflux
IPR036837 Cation_efflux_CTD_sf
IPR027469 Cation_efflux_TMD_sf
PfamiView protein in Pfam
PF01545 Cation_efflux, 1 hit
SUPFAMiSSF160240 SSF160240, 1 hit
SSF161111 SSF161111, 1 hit
TIGRFAMsiTIGR01297 CDF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiZNT4_HUMAN
AccessioniPrimary (citable) accession number: O14863
Secondary accession number(s): Q8TC39
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: September 23, 2008
Last modified: November 7, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again