UniProtKB - O14836 (TR13B_HUMAN)
Protein
Tumor necrosis factor receptor superfamily member 13B
Gene
TNFRSF13B
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity.2 Publications
GO - Molecular functioni
- signaling receptor activity Source: ProtInc
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- B cell homeostasis Source: GO_Central
- cell surface receptor signaling pathway Source: ProtInc
- hematopoietic progenitor cell differentiation Source: GO_Central
- negative regulation of B cell proliferation Source: GO_Central
- tumor necrosis factor-mediated signaling pathway Source: Reactome
Keywordsi
Molecular function | Receptor |
Biological process | Adaptive immunity, Immunity |
Enzyme and pathway databases
PathwayCommonsi | O14836 |
Reactomei | R-HSA-5669034, TNFs bind their physiological receptors |
SignaLinki | O14836 |
SIGNORi | O14836 |
Names & Taxonomyi
Protein namesi | Recommended name: Tumor necrosis factor receptor superfamily member 13BAlternative name(s): Transmembrane activator and CAML interactor CD_antigen: CD267 |
Gene namesi | Name:TNFRSF13B Synonyms:TACI |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000240505.8 |
HGNCi | HGNC:18153, TNFRSF13B |
MIMi | 604907, gene |
neXtProti | NX_O14836 |
Subcellular locationi
Other locations
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 165 | ExtracellularSequence analysisAdd BLAST | 165 | |
Transmembranei | 166 – 186 | Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 187 – 293 | CytoplasmicSequence analysisAdd BLAST | 107 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Involvement in diseasei
Immunodeficiency, common variable, 2 (CVID2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024027 | 104 | C → R in CVID2 and IGAD2. 1 PublicationCorresponds to variant dbSNP:rs34557412EnsemblClinVar. | 1 | |
Natural variantiVAR_024028 | 181 | A → G in CVID2. 1 Publication | 1 | |
Natural variantiVAR_024029 | 202 | R → H in CVID2. 1 PublicationCorresponds to variant dbSNP:rs104894649EnsemblClinVar. | 1 |
Immunoglobulin A deficiency 2 (IGAD2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionSelective deficiency of immunoglobulin A (IGAD) is the most common form of primary immunodeficiency, with an incidence of approximately 1 in 600 individuals in the western world. Individuals with symptomatic IGAD often have deficiency of IgG subclasses or decreased antibody response to carbohydrate antigens such as pneumococcal polysaccharide vaccine. Individuals with IGAD also suffer from recurrent sinopulmonary and gastrointestinal infections and have an increased incidence of autoimmune disorders and of lymphoid and non-lymphoid malignancies. In vitro studies have suggested that some individuals with IGAD have impaired isotype class switching to IgA and others may have a post-switch defect. IGAD and CVID have been known to coexist in families. Some individuals initially present with IGAD1 and then develop CVID. These observations suggest that some cases of IGAD and CVID may have a common etiology.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024027 | 104 | C → R in CVID2 and IGAD2. 1 PublicationCorresponds to variant dbSNP:rs34557412EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease mutationOrganism-specific databases
DisGeNETi | 23495 |
MalaCardsi | TNFRSF13B |
MIMi | 240500, phenotype 609529, phenotype |
OpenTargetsi | ENSG00000240505 |
Orphaneti | 1572, Common variable immunodeficiency 69127, NON RARE IN EUROPE: Immunoglobulin A deficiency |
PharmGKBi | PA38509 |
Miscellaneous databases
Pharosi | O14836, Tbio |
Polymorphism and mutation databases
BioMutai | TNFRSF13B |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000058931 | 1 – 293 | Tumor necrosis factor receptor superfamily member 13BAdd BLAST | 293 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 34 ↔ 47 | By similarity | ||
Disulfide bondi | 50 ↔ 62 | By similarity | ||
Disulfide bondi | 54 ↔ 66 | By similarity | ||
Disulfide bondi | 71 ↔ 86 | |||
Disulfide bondi | 89 ↔ 100 | |||
Disulfide bondi | 93 ↔ 104 | |||
Glycosylationi | 128 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MassIVEi | O14836 |
PaxDbi | O14836 |
PeptideAtlasi | O14836 |
PRIDEi | O14836 |
ProteomicsDBi | 48270 [O14836-1] 48271 [O14836-2] |
PTM databases
GlyGeni | O14836, 1 site |
iPTMneti | O14836 |
PhosphoSitePlusi | O14836 |
SwissPalmi | O14836 |
Expressioni
Tissue specificityi
Highly expressed in spleen, thymus, small intestine and peripheral blood leukocytes. Expressed in resting B-cells and activated T-cells, but not in resting T-cells.
Gene expression databases
Bgeei | ENSG00000240505, Expressed in adrenal gland and 144 other tissues |
ExpressionAtlasi | O14836, baseline and differential |
Genevisiblei | O14836, HS |
Organism-specific databases
HPAi | ENSG00000240505, Tissue enhanced (blood, lymphoid tissue, skeletal muscle) |
Interactioni
Subunit structurei
Binds TRAF2, TRAF5 and TRAF6. Binds the NH2-terminal domain of CAMLG with its C-terminus.
1 PublicationBinary interactionsi
Hide detailsO14836
With | #Exp. | IntAct |
---|---|---|
MYD88 [Q99836] | 12 | EBI-519160,EBI-447677 |
SGTA [O43765] | 3 | EBI-519160,EBI-347996 |
TNFSF13B [Q9Y275] | 7 | EBI-519160,EBI-519169 |
Isoform 2 [O14836-2]
With | #Exp. | IntAct |
---|---|---|
SGTA [O43765] | 8 | EBI-12023110,EBI-347996 |
Protein-protein interaction databases
BioGRIDi | 117046, 36 interactors |
DIPi | DIP-6224N |
IntActi | O14836, 35 interactors |
STRINGi | 9606.ENSP00000261652 |
Miscellaneous databases
RNActi | O14836, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | O14836 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O14836 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 33 – 67 | TNFR-Cys 1Add BLAST | 35 | |
Repeati | 70 – 104 | TNFR-Cys 2Add BLAST | 35 |
Keywords - Domaini
Repeat, Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502SANG, Eukaryota |
GeneTreei | ENSGT00390000013910 |
HOGENOMi | CLU_086237_0_0_1 |
InParanoidi | O14836 |
OMAi | CHCREDP |
OrthoDBi | 702827at2759 |
PhylomeDBi | O14836 |
TreeFami | TF337993 |
Family and domain databases
CDDi | cd13415, TNFRSF13B, 1 hit |
InterProi | View protein in InterPro IPR015384, TACI_Cys-rich-dom IPR022317, TNFR_13B |
PANTHERi | PTHR15511, PTHR15511, 1 hit |
Pfami | View protein in Pfam PF09305, TACI-CRD2, 2 hits |
PRINTSi | PR01963, TNFACTORR13B |
PROSITEi | View protein in PROSITE PS00652, TNFR_NGFR_1, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O14836-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSGLGRSRRG GRSRVDQEER FPQGLWTGVA MRSCPEEQYW DPLLGTCMSC
60 70 80 90 100
KTICNHQSQR TCAAFCRSLS CRKEQGKFYD HLLRDCISCA SICGQHPKQC
110 120 130 140 150
AYFCENKLRS PVNLPPELRR QRSGEVENNS DNSGRYQGLE HRGSEASPAL
160 170 180 190 200
PGLKLSADQV ALVYSTLGLC LCAVLCCFLV AVACFLKKRG DPCSCQPRSR
210 220 230 240 250
PRQSPAKSSQ DHAMEAGSPV STSPEPVETC SFCFPECRAP TQESAVTPGT
260 270 280 290
PDPTCAGRWG CHTRTTVLQP CPHIPDSGLG IVCVPAQEGG PGA
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7ER05 | E7ER05_HUMAN | Tumor necrosis factor receptor supe... | TNFRSF13B | 248 | Annotation score: | ||
J3QR67 | J3QR67_HUMAN | Tumor necrosis factor receptor supe... | TNFRSF13B | 156 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_064758 | 56 | H → N Found in a renal cell carcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_024027 | 104 | C → R in CVID2 and IGAD2. 1 PublicationCorresponds to variant dbSNP:rs34557412EnsemblClinVar. | 1 | |
Natural variantiVAR_024028 | 181 | A → G in CVID2. 1 Publication | 1 | |
Natural variantiVAR_024029 | 202 | R → H in CVID2. 1 PublicationCorresponds to variant dbSNP:rs104894649EnsemblClinVar. | 1 | |
Natural variantiVAR_052353 | 251 | P → L1 PublicationCorresponds to variant dbSNP:rs34562254EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_013798 | 21 – 67 | FPQGL…AAFCR → W in isoform 2. 2 PublicationsAdd BLAST | 47 | |
Alternative sequenceiVSP_054184 | 150 – 176 | LPGLK…CAVLC → PRGCPAPGTRKSFWDKENFQ GEGFHLG in isoform 3. 1 PublicationAdd BLAST | 27 | |
Alternative sequenceiVSP_054185 | 177 – 293 | Missing in isoform 3. 1 PublicationAdd BLAST | 117 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF023614 mRNA Translation: AAC51790.1 AY302137 mRNA Translation: AAP57629.1 AK301032 mRNA Translation: BAH13394.1 AK313302 mRNA Translation: BAG36107.1 CH471196 Genomic DNA Translation: EAW55729.1 BC109392 mRNA Translation: AAI09393.1 |
CCDSi | CCDS11181.1 [O14836-1] |
RefSeqi | NP_036584.1, NM_012452.2 [O14836-1] |
Genome annotation databases
Ensembli | ENST00000261652; ENSP00000261652; ENSG00000240505 [O14836-1] ENST00000583789; ENSP00000462952; ENSG00000240505 [O14836-2] |
GeneIDi | 23495 |
KEGGi | hsa:23495 |
UCSCi | uc002gqt.2, human [O14836-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
TNFRSF13Bbase TNFRSF13B mutation db |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF023614 mRNA Translation: AAC51790.1 AY302137 mRNA Translation: AAP57629.1 AK301032 mRNA Translation: BAH13394.1 AK313302 mRNA Translation: BAG36107.1 CH471196 Genomic DNA Translation: EAW55729.1 BC109392 mRNA Translation: AAI09393.1 |
CCDSi | CCDS11181.1 [O14836-1] |
RefSeqi | NP_036584.1, NM_012452.2 [O14836-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1XU1 | X-ray | 1.90 | R/S/T | 68-109 | [»] | |
1XUT | NMR | - | A | 68-109 | [»] | |
SMRi | O14836 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 117046, 36 interactors |
DIPi | DIP-6224N |
IntActi | O14836, 35 interactors |
STRINGi | 9606.ENSP00000261652 |
PTM databases
GlyGeni | O14836, 1 site |
iPTMneti | O14836 |
PhosphoSitePlusi | O14836 |
SwissPalmi | O14836 |
Polymorphism and mutation databases
BioMutai | TNFRSF13B |
Proteomic databases
MassIVEi | O14836 |
PaxDbi | O14836 |
PeptideAtlasi | O14836 |
PRIDEi | O14836 |
ProteomicsDBi | 48270 [O14836-1] 48271 [O14836-2] |
Protocols and materials databases
Antibodypediai | 35076, 622 antibodies |
Genome annotation databases
Ensembli | ENST00000261652; ENSP00000261652; ENSG00000240505 [O14836-1] ENST00000583789; ENSP00000462952; ENSG00000240505 [O14836-2] |
GeneIDi | 23495 |
KEGGi | hsa:23495 |
UCSCi | uc002gqt.2, human [O14836-1] |
Organism-specific databases
CTDi | 23495 |
DisGeNETi | 23495 |
EuPathDBi | HostDB:ENSG00000240505.8 |
GeneCardsi | TNFRSF13B |
HGNCi | HGNC:18153, TNFRSF13B |
HPAi | ENSG00000240505, Tissue enhanced (blood, lymphoid tissue, skeletal muscle) |
MalaCardsi | TNFRSF13B |
MIMi | 240500, phenotype 604907, gene 609529, phenotype |
neXtProti | NX_O14836 |
OpenTargetsi | ENSG00000240505 |
Orphaneti | 1572, Common variable immunodeficiency 69127, NON RARE IN EUROPE: Immunoglobulin A deficiency |
PharmGKBi | PA38509 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SANG, Eukaryota |
GeneTreei | ENSGT00390000013910 |
HOGENOMi | CLU_086237_0_0_1 |
InParanoidi | O14836 |
OMAi | CHCREDP |
OrthoDBi | 702827at2759 |
PhylomeDBi | O14836 |
TreeFami | TF337993 |
Enzyme and pathway databases
PathwayCommonsi | O14836 |
Reactomei | R-HSA-5669034, TNFs bind their physiological receptors |
SignaLinki | O14836 |
SIGNORi | O14836 |
Miscellaneous databases
BioGRID-ORCSi | 23495, 6 hits in 841 CRISPR screens |
ChiTaRSi | TNFRSF13B, human |
EvolutionaryTracei | O14836 |
GeneWikii | TNFRSF13B |
GenomeRNAii | 23495 |
Pharosi | O14836, Tbio |
PROi | PR:O14836 |
RNActi | O14836, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000240505, Expressed in adrenal gland and 144 other tissues |
ExpressionAtlasi | O14836, baseline and differential |
Genevisiblei | O14836, HS |
Family and domain databases
CDDi | cd13415, TNFRSF13B, 1 hit |
InterProi | View protein in InterPro IPR015384, TACI_Cys-rich-dom IPR022317, TNFR_13B |
PANTHERi | PTHR15511, PTHR15511, 1 hit |
Pfami | View protein in Pfam PF09305, TACI-CRD2, 2 hits |
PRINTSi | PR01963, TNFACTORR13B |
PROSITEi | View protein in PROSITE PS00652, TNFR_NGFR_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TR13B_HUMAN | |
Accessioni | O14836Primary (citable) accession number: O14836 Secondary accession number(s): B2R8B0 Q7Z6F5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 27, 2002 |
Last sequence update: | January 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 173 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries