TNFRSF13B

Functionⁱ

Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity.2 Publications

GO - Molecular functionⁱ

signaling receptor activity
Source: ProtInc
Traceable author statementⁱ
- 9311921

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adaptive immune response Source: UniProtKB-KW
B cell homeostasis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cell surface receptor signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 9311921
hematopoietic progenitor cell differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of B cell proliferation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
tumor necrosis factor-mediated signaling pathway Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Receptor
Biological process	Adaptive immunity, Immunity

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5669034 TNFs bind their physiological receptors
SignaLinkⁱ	O14836
SIGNORⁱ	O14836

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tumor necrosis factor receptor superfamily member 13B Alternative name(s): Transmembrane activator and CAML interactor CD_antigen: CD267
Gene namesⁱ	Name:TNFRSF13B Synonyms:TACI
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000240505.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:18153 TNFRSF13B
MIMⁱ	604907 gene
neXtProtⁱ	NX_O14836

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 165	ExtracellularSequence analysisAdd BLAST	165
Transmembraneⁱ	166 – 186	Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST	21
Topological domainⁱ	187 – 293	CytoplasmicSequence analysisAdd BLAST	107

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Immunodeficiency, common variable, 2 (CVID2)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_024028	181	A → G in CVID2. 1 Publication		1
Natural variantⁱVAR_024029	202	R → H in CVID2. 1 PublicationCorresponds to variant dbSNP:rs104894649EnsemblClinVar.		1

Immunoglobulin A deficiency 2 (IGAD2)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionSelective deficiency of immunoglobulin A (IGAD) is the most common form of primary immunodeficiency, with an incidence of approximately 1 in 600 individuals in the western world. Individuals with symptomatic IGAD often have deficiency of IgG subclasses or decreased antibody response to carbohydrate antigens such as pneumococcal polysaccharide vaccine. Individuals with IGAD also suffer from recurrent sinopulmonary and gastrointestinal infections and have an increased incidence of autoimmune disorders and of lymphoid and non-lymphoid malignancies. In vitro studies have suggested that some individuals with IGAD have impaired isotype class switching to IgA and others may have a post-switch defect. IGAD and CVID have been known to coexist in families. Some individuals initially present with IGAD1 and then develop CVID. These observations suggest that some cases of IGAD and CVID may have a common etiology.

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	23495
GeneReviewsⁱ	TNFRSF13B
MalaCards human disease database More...MalaCardsⁱ	TNFRSF13B
MIMⁱ	240500 phenotype 609529 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000240505
Orphanetⁱ	1572 Common variable immunodeficiency 69127 NON RARE IN EUROPE: Immunoglobulin A deficiency
PharmGKBⁱ	PA38509

Polymorphism and mutation databases

BioMutaⁱ	TNFRSF13B

BioMutaⁱ

TNFRSF13B

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000058931	1 – 293	Tumor necrosis factor receptor superfamily member 13BAdd BLAST		293

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	34 ↔ 47	By similarity
Disulfide bondⁱ	50 ↔ 62	By similarity
Disulfide bondⁱ	54 ↔ 66	By similarity
Disulfide bondⁱ	71 ↔ 86
Disulfide bondⁱ	89 ↔ 100
Disulfide bondⁱ	93 ↔ 104
Glycosylationⁱ	128	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	O14836
PeptideAtlas More...PeptideAtlasⁱ	O14836
PRIDEⁱ	O14836
ProteomicsDBⁱ	48270 48271 [O14836-2]

PTM databases

iPTMnetⁱ	O14836
PhosphoSitePlusⁱ	O14836
SwissPalmⁱ	O14836

Expressionⁱ

Tissue specificityⁱ

Highly expressed in spleen, thymus, small intestine and peripheral blood leukocytes. Expressed in resting B-cells and activated T-cells, but not in resting T-cells.

Gene expression databases

Bgeeⁱ	ENSG00000240505 Expressed in 128 organ(s), highest expression level in adrenal gland
CleanExⁱ	HS_TNFRSF13B
ExpressionAtlasⁱ	O14836 baseline and differential
Genevisibleⁱ	O14836 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA030453

HPAⁱ

HPA030453

Interactionⁱ

Subunit structureⁱ

Binds TRAF2, TRAF5 and TRAF6. Binds the NH2-terminal domain of CAMLG with its C-terminus.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
MYD88	Q99836	12	EBI-519160,EBI-447677
SGTA	O43765	5	EBI-12023110,EBI-347996
TNFSF13B	Q9Y275	7	EBI-519160,EBI-519169

Protein-protein interaction databases

BioGridⁱ	117046, 36 interactors
Database of interacting proteins More...DIPⁱ	DIP-6224N
IntActⁱ	O14836, 12 interactors
STRINGⁱ	9606.ENSP00000261652

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	73 – 75	Combined sources	3
Beta strandⁱ	77 – 80	Combined sources	4
Turnⁱ	81 – 84	Combined sources	4
Beta strandⁱ	85 – 88	Combined sources	4
Helixⁱ	89 – 92	Combined sources	4
Helixⁱ	98 – 100	Combined sources	3
Helixⁱ	101 – 104	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	O14836
SMRⁱ	O14836
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	O14836

EvolutionaryTraceⁱ

O14836

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Repeatⁱ	33 – 67	TNFR-Cys 1Add BLAST		35
Repeatⁱ	70 – 104	TNFR-Cys 2Add BLAST		35

Keywords - Domainⁱ

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IHJ8 Eukaryota ENOG410Z545 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013910
HOGENOMⁱ	HOG000273905
HOVERGENⁱ	HBG058015
InParanoidⁱ	O14836
KEGG Orthology (KO) More...KOⁱ	K05150
OMAⁱ	PVETCGF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0ISO
PhylomeDBⁱ	O14836
TreeFamⁱ	TF337993

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd13415 TNFRSF13B, 1 hit
InterProⁱ	View protein in InterPro IPR015384 TACI_Cys-rich-dom IPR022317 TNFR_13B
PANTHERⁱ	PTHR15511 PTHR15511, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF09305 TACI-CRD2, 2 hits
PRINTSⁱ	PR01963 TNFACTORR13B
PROSITEⁱ	View protein in PROSITE PS00652 TNFR_NGFR_1, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O14836-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGLGRSRRG GRSRVDQEER FPQGLWTGVA MRSCPEEQYW DPLLGTCMSC 
        60         70         80         90        100
KTICNHQSQR TCAAFCRSLS CRKEQGKFYD HLLRDCISCA SICGQHPKQC 
       110        120        130        140        150
AYFCENKLRS PVNLPPELRR QRSGEVENNS DNSGRYQGLE HRGSEASPAL 
       160        170        180        190        200
PGLKLSADQV ALVYSTLGLC LCAVLCCFLV AVACFLKKRG DPCSCQPRSR 
       210        220        230        240        250
PRQSPAKSSQ DHAMEAGSPV STSPEPVETC SFCFPECRAP TQESAVTPGT 
       260        270        280        290 
PDPTCAGRWG CHTRTTVLQP CPHIPDSGLG IVCVPAQEGG PGA

Length:293

Mass (Da):31,816

Last modified:January 1, 1998 - v1

Checksum:ⁱ411799F3DE17A5EB

GO

Isoform 2 (identifier: O14836-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
21-67: FPQGLWTGVAMRSCPEEQYWDPLLGTCMSCKTICNHQSQRTCAAFCR → W

« Hide

        10         20         30         40         50
MSGLGRSRRG GRSRVDQEER WSLSCRKEQG KFYDHLLRDC ISCASICGQH 
        60         70         80         90        100
PKQCAYFCEN KLRSPVNLPP ELRRQRSGEV ENNSDNSGRY QGLEHRGSEA 
       110        120        130        140        150
SPALPGLKLS ADQVALVYST LGLCLCAVLC CFLVAVACFL KKRGDPCSCQ 
       160        170        180        190        200
PRSRPRQSPA KSSQDHAMEA GSPVSTSPEP VETCSFCFPE CRAPTQESAV 
       210        220        230        240 
TPGTPDPTCA GRWGCHTRTT VLQPCPHIPD SGLGIVCVPA QEGGPGA

Show »

Length:247

Mass (Da):26,664

Checksum:ⁱ850E1F4C2578E8E6

GO

Isoform 3 (identifier: O14836-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
150-176: LPGLKLSADQVALVYSTLGLCLCAVLC → PRGCPAPGTRKSFWDKENFQGEGFHLG
177-293: Missing.

« Hide

        10         20         30         40         50
MSGLGRSRRG GRSRVDQEER FPQGLWTGVA MRSCPEEQYW DPLLGTCMSC 
        60         70         80         90        100
KTICNHQSQR TCAAFCRSLS CRKEQGKFYD HLLRDCISCA SICGQHPKQC 
       110        120        130        140        150
AYFCENKLRS PVNLPPELRR QRSGEVENNS DNSGRYQGLE HRGSEASPAP 
       160        170 
RGCPAPGTRK SFWDKENFQG EGFHLG

Note: No experimental confirmation available.

Show »

Length:176

Mass (Da):19,865

Checksum:ⁱ4506764708AF788C

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E7ER05	E7ER05_HUMAN	Tumor necrosis factor receptor supe... Tumor necrosis factor receptor superfamily member 13B	TNFRSF13B	248	Annotation score:
J3QR67	J3QR67_HUMAN	Tumor necrosis factor receptor supe... Tumor necrosis factor receptor superfamily member 13B	TNFRSF13B	156	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_064758	56	H → N Found in a renal cell carcinoma sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_024027	104	C → R in CVID2 and IGAD2. 1 PublicationCorresponds to variant dbSNP:rs34557412EnsemblClinVar.	1
Natural variantⁱVAR_024028	181	A → G in CVID2. 1 Publication	1
Natural variantⁱVAR_024029	202	R → H in CVID2. 1 PublicationCorresponds to variant dbSNP:rs104894649EnsemblClinVar.	1
Natural variantⁱVAR_052353	251	P → L1 PublicationCorresponds to variant dbSNP:rs34562254EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_013798	21 – 67	FPQGL…AAFCR → W in isoform 2. 2 PublicationsAdd BLAST	47
Alternative sequenceⁱVSP_054184	150 – 176	LPGLK…CAVLC → PRGCPAPGTRKSFWDKENFQ GEGFHLG in isoform 3. 1 PublicationAdd BLAST	27
Alternative sequenceⁱVSP_054185	177 – 293	Missing in isoform 3. 1 PublicationAdd BLAST	117

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF023614 mRNA Translation: AAC51790.1 AY302137 mRNA Translation: AAP57629.1 AK301032 mRNA Translation: BAH13394.1 AK313302 mRNA Translation: BAG36107.1 CH471196 Genomic DNA Translation: EAW55729.1 BC109392 mRNA Translation: AAI09393.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11181.1 [O14836-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_036584.1, NM_012452.2 [O14836-1]
UniGeneⁱ	Hs.158341

Genome annotation databases

Ensemblⁱ	ENST00000261652; ENSP00000261652; ENSG00000240505 [O14836-1] ENST00000583789; ENSP00000462952; ENSG00000240505 [O14836-2]
GeneIDⁱ	23495
KEGGⁱ	hsa:23495
UCSC genome browser More...UCSCⁱ	uc002gqt.2 human [O14836-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O14836	TACI		HUMAN		293	UniRef100_O14836

Protein	Similar proteins		Species	Score	Length	Source
O14836	TACI		HUMAN		293	UniRef90_O14836
TNF receptor superfamily member 13B		PANTR		293
Uncharacterized protein		PANPA		293
Transmembrane activator and CAML interactor		MACMU		293
Uncharacterized protein		COLAP		293
+22
O14836-3	Uncharacterized protein		MACFA		156	UniRef90_O14836-3
TNF receptor superfamily member 13B		PANTR		156
Uncharacterized protein		PANPA		156
TNF receptor superfamily member 13B		GORGO		156
Uncharacterized protein		MACNE		156
+7

Protein	Similar proteins		Species	Score	Length	Source
O14836	TACI		HUMAN		293	UniRef50_O14836
TNF receptor superfamily member 13B		PANTR		293
Uncharacterized protein		PANPA		293
Transmembrane activator and CAML interactor		MACMU		293
Uncharacterized protein		MACNE		293
+73
O14836-3	Uncharacterized protein		MACMU		156	UniRef50_O14836-3
Uncharacterized protein		PAPAN		156
Uncharacterized protein		RHIRO		156
Uncharacterized protein		RHIBE		156
Uncharacterized protein		MACFA		156
+13

Cross-referencesⁱ

Web resourcesⁱ

TNFRSF13Bbase

TNFRSF13B mutation db

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF023614 mRNA Translation: AAC51790.1 AY302137 mRNA Translation: AAP57629.1 AK301032 mRNA Translation: BAH13394.1 AK313302 mRNA Translation: BAG36107.1 CH471196 Genomic DNA Translation: EAW55729.1 BC109392 mRNA Translation: AAI09393.1
CCDSⁱ	CCDS11181.1 [O14836-1]
RefSeqⁱ	NP_036584.1, NM_012452.2 [O14836-1]
UniGeneⁱ	Hs.158341

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1XU1	X-ray	1.90	R/S/T	68-109	[»]
	1XUT	NMR	-	A	68-109	[»]
ProteinModelPortalⁱ	O14836
SMRⁱ	O14836
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117046, 36 interactors
DIPⁱ	DIP-6224N
IntActⁱ	O14836, 12 interactors
STRINGⁱ	9606.ENSP00000261652

PTM databases

iPTMnetⁱ	O14836
PhosphoSitePlusⁱ	O14836
SwissPalmⁱ	O14836

Polymorphism and mutation databases

BioMutaⁱ	TNFRSF13B

BioMutaⁱ

TNFRSF13B

Proteomic databases

PaxDbⁱ	O14836
PeptideAtlasⁱ	O14836
PRIDEⁱ	O14836
ProteomicsDBⁱ	48270 48271 [O14836-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000261652; ENSP00000261652; ENSG00000240505 [O14836-1] ENST00000583789; ENSP00000462952; ENSG00000240505 [O14836-2]
GeneIDⁱ	23495
KEGGⁱ	hsa:23495
UCSCⁱ	uc002gqt.2 human [O14836-1]

Organism-specific databases

CTDⁱ	23495
DisGeNETⁱ	23495
EuPathDBⁱ	HostDB:ENSG00000240505.8
GeneCardsⁱ	TNFRSF13B
GeneReviewsⁱ	TNFRSF13B
H-InvDBⁱ	HIX0173687
HGNCⁱ	HGNC:18153 TNFRSF13B
HPAⁱ	HPA030453
MalaCardsⁱ	TNFRSF13B
MIMⁱ	240500 phenotype 604907 gene 609529 phenotype
neXtProtⁱ	NX_O14836
OpenTargetsⁱ	ENSG00000240505
Orphanetⁱ	1572 Common variable immunodeficiency 69127 NON RARE IN EUROPE: Immunoglobulin A deficiency
PharmGKBⁱ	PA38509
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IHJ8 Eukaryota ENOG410Z545 LUCA
GeneTreeⁱ	ENSGT00390000013910
HOGENOMⁱ	HOG000273905
HOVERGENⁱ	HBG058015
InParanoidⁱ	O14836
KOⁱ	K05150
OMAⁱ	PVETCGF
OrthoDBⁱ	EOG091G0ISO
PhylomeDBⁱ	O14836
TreeFamⁱ	TF337993

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5669034 TNFs bind their physiological receptors
SignaLinkⁱ	O14836
SIGNORⁱ	O14836

Miscellaneous databases

ChiTaRSⁱ	TNFRSF13B human
EvolutionaryTraceⁱ	O14836
GeneWikiⁱ	TNFRSF13B
GenomeRNAiⁱ	23495
Protein Ontology More...PROⁱ	PR:O14836
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000240505 Expressed in 128 organ(s), highest expression level in adrenal gland
CleanExⁱ	HS_TNFRSF13B
ExpressionAtlasⁱ	O14836 baseline and differential
Genevisibleⁱ	O14836 HS

Family and domain databases

CDDⁱ	cd13415 TNFRSF13B, 1 hit
InterProⁱ	View protein in InterPro IPR015384 TACI_Cys-rich-dom IPR022317 TNFR_13B
PANTHERⁱ	PTHR15511 PTHR15511, 1 hit
Pfamⁱ	View protein in Pfam PF09305 TACI-CRD2, 2 hits
PRINTSⁱ	PR01963 TNFACTORR13B
PROSITEⁱ	View protein in PROSITE PS00652 TNFR_NGFR_1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TR13B_HUMAN
Accessionⁱ	O14836Primary (citable) accession number: O14836 Secondary accession number(s): B2R8B0 , B7Z6V8, Q32LX4, Q7Z6F5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 27, 2002
	Last sequence update:	January 1, 1998
	Last modified:	November 7, 2018
	This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries

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UniProtKB - O14836 (TR13B_HUMAN)

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Tumor necrosis factor receptor superfamily member 13B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Plasma Membrane

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

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Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

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Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ