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Protein

Tetraspanin-4

Gene

TSPAN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • antigen binding Source: UniProtKB
  • integrin binding Source: UniProtKB

GO - Biological processi

  • cell surface receptor signaling pathway Source: GO_Central
  • protein-containing complex assembly Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-4
Short name:
Tspan-4
Alternative name(s):
Novel antigen 2
Short name:
NAG-2
Transmembrane 4 superfamily member 7
Gene namesi
Name:TSPAN4
Synonyms:NAG2, TM4SF7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000214063.10
HGNCiHGNC:11859 TSPAN4
MIMi602644 gene
neXtProtiNX_O14817

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Topological domaini35 – 55ExtracellularSequence analysisAdd BLAST21
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Topological domaini77 – 85CytoplasmicSequence analysis9
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Topological domaini107 – 201ExtracellularSequence analysisAdd BLAST95
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Topological domaini223 – 238CytoplasmicSequence analysisAdd BLAST16

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi7106
OpenTargetsiENSG00000214063
PharmGKBiPA36560

Polymorphism and mutation databases

BioMutaiTSPAN4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192411 – 238Tetraspanin-4Add BLAST238

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi152N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi161N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiO14817
MaxQBiO14817
PaxDbiO14817
PeptideAtlasiO14817
PRIDEiO14817
ProteomicsDBi48255

PTM databases

iPTMnetiO14817
SwissPalmiO14817

Expressioni

Tissue specificityi

Expressed in multiple tissues but is absent in brain, lymphoid cells, and platelets.

Gene expression databases

BgeeiENSG00000214063 Expressed in 219 organ(s), highest expression level in endocervix
CleanExiHS_TSPAN4
ExpressionAtlasiO14817 baseline and differential
GenevisibleiO14817 HS

Interactioni

Subunit structurei

Forms a complex with integrins.

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112961, 8 interactors
IntActiO14817, 39 interactors
MINTiO14817
STRINGi9606.ENSP00000380552

Structurei

3D structure databases

ProteinModelPortaliO14817
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137858
HOGENOMiHOG000230651
HOVERGENiHBG002324
InParanoidiO14817
KOiK17294
PhylomeDBiO14817
TreeFamiTF352892

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

O14817-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARACLQAVK YLMFAFNLLF WLGGCGVLGV GIWLAATQGS FATLSSSFPS
60 70 80 90 100
LSAANLLIIT GAFVMAIGFV GCLGAIKENK CLLLTFFLLL LLVFLLEATI
110 120 130 140 150
AILFFAYTDK IDRYAQQDLK KGLHLYGTQG NVGLTNAWSI IQTDFRCCGV
160 170 180 190 200
SNYTDWFEVY NATRVPDSCC LEFSESCGLH APGTWWKAPC YETVKVWLQE
210 220 230
NLLAVGIFGL CTALVQILGL TFAMTMYCQV VKADTYCA
Length:238
Mass (Da):26,118
Last modified:January 1, 1998 - v1
Checksum:iA6B9A5633065A492
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MVV6A8MVV6_HUMAN
Tetraspanin
TSPAN4
174Annotation score:
E9PPX8E9PPX8_HUMAN
Tetraspanin
TSPAN4
159Annotation score:
J3KQ42J3KQ42_HUMAN
Tetraspanin
TSPAN4
257Annotation score:
J3KNL1J3KNL1_HUMAN
Tetraspanin
TSPAN4
204Annotation score:
E9PMX4E9PMX4_HUMAN
Tetraspanin-4
TSPAN4
85Annotation score:
E9PN41E9PN41_HUMAN
Tetraspanin-4
TSPAN4
132Annotation score:
E9PSH3E9PSH3_HUMAN
Tetraspanin-4
TSPAN4
100Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03661667I → M in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022813 mRNA Translation: AAC51864.1
AF054841 mRNA Translation: AAC69717.1
AK291089 mRNA Translation: BAF83778.1
BT006776 mRNA Translation: AAP35422.1
CR457108 mRNA Translation: CAG33389.1
CH471158 Genomic DNA Translation: EAX02409.1
BC000389 mRNA Translation: AAH00389.1
BC019314 mRNA Translation: AAH19314.1
BC093031 mRNA Translation: AAH93031.1
CCDSiCCDS7721.1
PIRiA59265
RefSeqiNP_001020405.1, NM_001025234.1
NP_001020406.1, NM_001025235.1
NP_001020407.1, NM_001025236.1
NP_001020408.1, NM_001025237.1
NP_001020409.1, NM_001025238.1
NP_001020410.1, NM_001025239.1
NP_003262.1, NM_003271.4
XP_005253159.1, XM_005253102.1
UniGeneiHs.654836

Genome annotation databases

EnsembliENST00000397397; ENSP00000380552; ENSG00000214063
ENST00000397404; ENSP00000380553; ENSG00000214063
ENST00000397406; ENSP00000380554; ENSG00000214063
ENST00000397408; ENSP00000380555; ENSG00000214063
ENST00000397411; ENSP00000380558; ENSG00000214063
ENST00000409543; ENSP00000386513; ENSG00000214063
GeneIDi7106
KEGGihsa:7106
UCSCiuc001lsd.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022813 mRNA Translation: AAC51864.1
AF054841 mRNA Translation: AAC69717.1
AK291089 mRNA Translation: BAF83778.1
BT006776 mRNA Translation: AAP35422.1
CR457108 mRNA Translation: CAG33389.1
CH471158 Genomic DNA Translation: EAX02409.1
BC000389 mRNA Translation: AAH00389.1
BC019314 mRNA Translation: AAH19314.1
BC093031 mRNA Translation: AAH93031.1
CCDSiCCDS7721.1
PIRiA59265
RefSeqiNP_001020405.1, NM_001025234.1
NP_001020406.1, NM_001025235.1
NP_001020407.1, NM_001025236.1
NP_001020408.1, NM_001025237.1
NP_001020409.1, NM_001025238.1
NP_001020410.1, NM_001025239.1
NP_003262.1, NM_003271.4
XP_005253159.1, XM_005253102.1
UniGeneiHs.654836

3D structure databases

ProteinModelPortaliO14817
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112961, 8 interactors
IntActiO14817, 39 interactors
MINTiO14817
STRINGi9606.ENSP00000380552

PTM databases

iPTMnetiO14817
SwissPalmiO14817

Polymorphism and mutation databases

BioMutaiTSPAN4

Proteomic databases

EPDiO14817
MaxQBiO14817
PaxDbiO14817
PeptideAtlasiO14817
PRIDEiO14817
ProteomicsDBi48255

Protocols and materials databases

DNASUi7106
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397397; ENSP00000380552; ENSG00000214063
ENST00000397404; ENSP00000380553; ENSG00000214063
ENST00000397406; ENSP00000380554; ENSG00000214063
ENST00000397408; ENSP00000380555; ENSG00000214063
ENST00000397411; ENSP00000380558; ENSG00000214063
ENST00000409543; ENSP00000386513; ENSG00000214063
GeneIDi7106
KEGGihsa:7106
UCSCiuc001lsd.2 human

Organism-specific databases

CTDi7106
DisGeNETi7106
EuPathDBiHostDB:ENSG00000214063.10
GeneCardsiTSPAN4
HGNCiHGNC:11859 TSPAN4
MIMi602644 gene
neXtProtiNX_O14817
OpenTargetsiENSG00000214063
PharmGKBiPA36560
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137858
HOGENOMiHOG000230651
HOVERGENiHBG002324
InParanoidiO14817
KOiK17294
PhylomeDBiO14817
TreeFamiTF352892

Miscellaneous databases

ChiTaRSiTSPAN4 human
GeneWikiiTSPAN4
GenomeRNAii7106
PROiPR:O14817
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000214063 Expressed in 219 organ(s), highest expression level in endocervix
CleanExiHS_TSPAN4
ExpressionAtlasiO14817 baseline and differential
GenevisibleiO14817 HS

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTSN4_HUMAN
AccessioniPrimary (citable) accession number: O14817
Secondary accession number(s): Q6IAP6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: September 12, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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