CPLX1

Functionⁱ

Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles (PubMed:21785414). Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse (PubMed:21785414). Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior.By similarity1 Publication

GO - Molecular functionⁱ

neurotransmitter transporter activity Source: Ensembl
SNARE binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
syntaxin-1 binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

chemical synaptic transmission
Source: ProtInc
Traceable author statementⁱ
- 7553862
exocytic insertion of neurotransmitter receptor to postsynaptic membrane Source: Ensembl
exocytosis
Source: ProtInc
Traceable author statementⁱ
- 7553862
insulin secretion Source: Ensembl
regulation of exocytosis
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 15217342
regulation of neurotransmitter secretion
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of synaptic vesicle fusion to presynaptic active zone membrane Source: Ensembl
synaptic vesicle exocytosis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Exocytosis, Neurotransmitter transport, Transport

Biological process

Exocytosis, Neurotransmitter transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-181429 Serotonin Neurotransmitter Release Cycle R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle R-HSA-210500 Glutamate Neurotransmitter Release Cycle R-HSA-212676 Dopamine Neurotransmitter Release Cycle R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle R-HSA-888590 GABA synthesis, release, reuptake and degradation

Reactomeⁱ

R-HSA-181429 Serotonin Neurotransmitter Release Cycle
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle
R-HSA-210500 Glutamate Neurotransmitter Release Cycle
R-HSA-212676 Dopamine Neurotransmitter Release Cycle
R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle
R-HSA-888590 GABA synthesis, release, reuptake and degradation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Complexin-1 Alternative name(s): Complexin I Short name: CPX I Synaphin-2
Gene namesⁱ	Name:CPLX1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000168993.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2309 CPLX1
MIMⁱ	605032 gene
neXtProtⁱ	NX_O14810

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Epileptic encephalopathy, early infantile, 63 (EIEE63)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. EIEE63 is an autosomal recessive disease with onset in infancy.

Keywords - Diseaseⁱ

Disease mutation, Epilepsy

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10815
MalaCards human disease database More...MalaCardsⁱ	CPLX1
MIMⁱ	617976 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000168993
Orphanetⁱ	352582 Familial infantile myoclonic epilepsy
PharmGKBⁱ	PA26826

Polymorphism and mutation databases

BioMutaⁱ	CPLX1

BioMutaⁱ

CPLX1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000144870	1 – 134	Complexin-1Add BLAST		134

Proteomic databases

EPDⁱ	O14810
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O14810
PaxDbⁱ	O14810
PeptideAtlas More...PeptideAtlasⁱ	O14810
PRIDEⁱ	O14810
ProteomicsDBⁱ	48251

PTM databases

iPTMnetⁱ	O14810
PhosphoSitePlusⁱ	O14810

Expressionⁱ

Tissue specificityⁱ

Nervous system. In hippocampus and cerebellum, expressed mainly by inhibitory neurons. Overexpressed in substantia nigra from patients with Parkinson disease.3 Publications

Gene expression databases

Bgeeⁱ	ENSG00000168993 Expressed in 137 organ(s), highest expression level in lateral nuclear group of thalamus
CleanExⁱ	HS_CPLX1
ExpressionAtlasⁱ	O14810 baseline and differential
Genevisibleⁱ	O14810 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA071191

HPAⁱ

HPA071191

Interactionⁱ

Subunit structureⁱ

Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
SNAP25	P60880-2	6	EBI-2691813,EBI-12177361

With

Entry

#Exp.

IntAct

Notes

SNAP25

P60880-2

6

EBI-2691813,EBI-12177361

GO - Molecular functionⁱ

SNARE binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
syntaxin-1 binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	116028, 37 interactors
CORUMⁱ	O14810
Database of interacting proteins More...DIPⁱ	DIP-56109N
IntActⁱ	O14810, 5 interactors
STRINGⁱ	9606.ENSP00000305613

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Helixⁱ	29 – 70	Combined sources		42

Show more details

3D structure databases

ProteinModelPortalⁱ	O14810
SMRⁱ	O14810
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	48 – 70	Interaction with the SNARE complexBy similarityAdd BLAST		23

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	29 – 69	Sequence analysisAdd BLAST		41

Sequence similaritiesⁱ

Belongs to the complexin/synaphin family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	ENOG410IWGS Eukaryota ENOG4111MX0 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00490000043416
HOGENOMⁱ	HOG000017716
HOVERGENⁱ	HBG062792
InParanoidⁱ	O14810
KEGG Orthology (KO) More...KOⁱ	K15294
OMAⁱ	TVMKFIP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0WGX
PhylomeDBⁱ	O14810
TreeFamⁱ	TF315172

Family and domain databases

InterProⁱ	View protein in InterPro IPR008849 Synaphin
PANTHERⁱ	PTHR16705 PTHR16705, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05835 Synaphin, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

O14810-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEFVMKQALG GATKDMGKML GGDEEKDPDA AKKEEERQEA LRQAEEERKA 
        60         70         80         90        100
KYAKMEAERE AVRQGIRDKY GIKKKEEREA EAQAAMEANS EGSLTRPKKA 
       110        120        130 
IPPGCGDEVE EEDESILDTV IKYLPGPLQD MLKK

Length:134

Mass (Da):15,030

Last modified:January 1, 1998 - v1

Checksum:ⁱA7A52F17F10D28A4

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D6RAG3	D6RAG3_HUMAN	Complexin-1 Complexin-1	CPLX1	110	Annotation score:
D6RI11	D6RI11_HUMAN	Complexin-1 Complexin-1	CPLX1	113	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_080795	105 – 134	Missing in EIEE63. 1 PublicationAdd BLAST	30
Natural variantⁱVAR_080796	108 – 134	Missing in EIEE63. 1 PublicationAdd BLAST	27
Natural variantⁱVAR_080797	128	L → M in EIEE63; unknown pathological significance. 1 Publication	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF022383 mRNA Translation: AAB72108.1 KJ534815 mRNA Translation: AHW56455.1 BT007029 mRNA Translation: AAP35676.1 AB593095 mRNA Translation: BAJ84035.1 AK311921 mRNA Translation: BAG34862.1 AC139887 Genomic DNA No translation available. CH471131 Genomic DNA Translation: EAW82648.1 CH471131 Genomic DNA Translation: EAW82649.1 BC002471 mRNA Translation: AAH02471.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS46995.1
NCBI Reference Sequences More...RefSeqⁱ	NP_006642.1, NM_006651.3
UniGeneⁱ	Hs.478930

Genome annotation databases

Ensemblⁱ	ENST00000304062; ENSP00000305613; ENSG00000168993
GeneIDⁱ	10815
KEGGⁱ	hsa:10815
UCSC genome browser More...UCSCⁱ	uc003gbi.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O14810	Complexin-1 (Fragment)		HUMAN		110	UniRef100_O14810
UPI0000E08C77		HUMAN		119

Protein	Similar proteins		Species	Score	Length	Source
O14810	Complexin-1		BOVIN		134	UniRef90_O14810
Complexin-1		MACFA		134
Complexin-1		NARJA		133
Complexin-1 (Fragment)		HUMAN		110
Complexin-1 isoform X1		AMAAE		152
+42

Protein	Similar proteins		Species	Score	Length	Source
O14810	Complexin-1		MOUSE		134	UniRef50_P63040
Complexin-1	)	RAT		134
Complexin-1		BOVIN		134
Complexin-1		MACFA		134
Complexin-1		NARJA		133
+158

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF022383 mRNA Translation: AAB72108.1 KJ534815 mRNA Translation: AHW56455.1 BT007029 mRNA Translation: AAP35676.1 AB593095 mRNA Translation: BAJ84035.1 AK311921 mRNA Translation: BAG34862.1 AC139887 Genomic DNA No translation available. CH471131 Genomic DNA Translation: EAW82648.1 CH471131 Genomic DNA Translation: EAW82649.1 BC002471 mRNA Translation: AAH02471.1
CCDSⁱ	CCDS46995.1
RefSeqⁱ	NP_006642.1, NM_006651.3
UniGeneⁱ	Hs.478930

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3RK3	X-ray	3.50	E	26-83	[»]
	3RL0	X-ray	3.80	g/h/i/j/k/l/m/n	26-83	[»]
ProteinModelPortalⁱ	O14810
SMRⁱ	O14810
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116028, 37 interactors
CORUMⁱ	O14810
DIPⁱ	DIP-56109N
IntActⁱ	O14810, 5 interactors
STRINGⁱ	9606.ENSP00000305613

PTM databases

iPTMnetⁱ	O14810
PhosphoSitePlusⁱ	O14810

Polymorphism and mutation databases

BioMutaⁱ	CPLX1

BioMutaⁱ

CPLX1

Proteomic databases

EPDⁱ	O14810
MaxQBⁱ	O14810
PaxDbⁱ	O14810
PeptideAtlasⁱ	O14810
PRIDEⁱ	O14810
ProteomicsDBⁱ	48251

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	10815
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000304062; ENSP00000305613; ENSG00000168993
GeneIDⁱ	10815
KEGGⁱ	hsa:10815
UCSCⁱ	uc003gbi.4 human

Organism-specific databases

CTDⁱ	10815
DisGeNETⁱ	10815
EuPathDBⁱ	HostDB:ENSG00000168993.14
GeneCardsⁱ	CPLX1
HGNCⁱ	HGNC:2309 CPLX1
HPAⁱ	HPA071191
MalaCardsⁱ	CPLX1
MIMⁱ	605032 gene 617976 phenotype
neXtProtⁱ	NX_O14810
OpenTargetsⁱ	ENSG00000168993
Orphanetⁱ	352582 Familial infantile myoclonic epilepsy
PharmGKBⁱ	PA26826
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IWGS Eukaryota ENOG4111MX0 LUCA
GeneTreeⁱ	ENSGT00490000043416
HOGENOMⁱ	HOG000017716
HOVERGENⁱ	HBG062792
InParanoidⁱ	O14810
KOⁱ	K15294
OMAⁱ	TVMKFIP
OrthoDBⁱ	EOG091G0WGX
PhylomeDBⁱ	O14810
TreeFamⁱ	TF315172

Enzyme and pathway databases

Reactomeⁱ	R-HSA-181429 Serotonin Neurotransmitter Release Cycle R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle R-HSA-210500 Glutamate Neurotransmitter Release Cycle R-HSA-212676 Dopamine Neurotransmitter Release Cycle R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle R-HSA-888590 GABA synthesis, release, reuptake and degradation

Reactomeⁱ

R-HSA-181429 Serotonin Neurotransmitter Release Cycle
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle
R-HSA-210500 Glutamate Neurotransmitter Release Cycle
R-HSA-212676 Dopamine Neurotransmitter Release Cycle
R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle
R-HSA-888590 GABA synthesis, release, reuptake and degradation

Miscellaneous databases

ChiTaRSⁱ	CPLX1 human
GeneWikiⁱ	CPLX1
GenomeRNAiⁱ	10815
Protein Ontology More...PROⁱ	PR:O14810
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000168993 Expressed in 137 organ(s), highest expression level in lateral nuclear group of thalamus
CleanExⁱ	HS_CPLX1
ExpressionAtlasⁱ	O14810 baseline and differential
Genevisibleⁱ	O14810 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR008849 Synaphin
PANTHERⁱ	PTHR16705 PTHR16705, 1 hit
Pfamⁱ	View protein in Pfam PF05835 Synaphin, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CPLX1_HUMAN
Accessionⁱ	O14810Primary (citable) accession number: O14810 Secondary accession number(s): A6NI80 , B2R4R5, D3DVN3, F1T0G1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
	Last sequence update:	January 1, 1998
	Last modified:	November 7, 2018
	This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O14810 (CPLX1_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Complexin-1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Cytosol

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ