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UniProtKB - O14810 (CPLX1_HUMAN)

Entry version 156 (29 Sep 2021)
Sequence version 1 (01 Jan 1998)
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Protein

Complexin-1

Gene

CPLX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles (PubMed:21785414).

Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse (PubMed:21785414).

Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior.

By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processExocytosis, Neurotransmitter transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O14810

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-181429, Serotonin Neurotransmitter Release Cycle
R-HSA-181430, Norepinephrine Neurotransmitter Release Cycle
R-HSA-210500, Glutamate Neurotransmitter Release Cycle
R-HSA-212676, Dopamine Neurotransmitter Release Cycle
R-HSA-264642, Acetylcholine Neurotransmitter Release Cycle
R-HSA-888590, GABA synthesis, release, reuptake and degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Complexin-1
Alternative name(s):
Complexin I
Short name:
CPX I
Synaphin-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CPLX1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:2309, CPLX1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605032, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O14810

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000168993

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Developmental and epileptic encephalopathy 63 (DEE63)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE63 is an autosomal recessive disease with onset in infancy.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_080795105 – 134Missing in DEE63. 1 PublicationAdd BLAST30
Natural variantiVAR_080796108 – 134Missing in DEE63. 1 PublicationAdd BLAST27
Natural variantiVAR_080797128L → M in DEE63; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs371709824EnsemblClinVar.1

Keywords - Diseasei

Disease variant, Epilepsy

Organism-specific databases

DisGeNET

More...DisGeNETi		10815

MalaCards human disease database

More...MalaCardsi		CPLX1
MIMi617976, phenotype

Open Targets

More...OpenTargetsi		ENSG00000168993

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		352582, Familial infantile myoclonic epilepsy
280, Wolf-Hirschhorn syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26826

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O14810, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CPLX1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001448701 – 134Complexin-1Add BLAST134

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O14810

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O14810

MaxQB - The MaxQuant DataBase

More...MaxQBi		O14810

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O14810

PeptideAtlas

More...PeptideAtlasi		O14810

PRoteomics IDEntifications database

More...PRIDEi		O14810

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		48251

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O14810

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O14810

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Nervous system. In hippocampus and cerebellum, expressed mainly by inhibitory neurons. Overexpressed in substantia nigra from patients with Parkinson disease.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000168993, Expressed in lateral nuclear group of thalamus and 153 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O14810, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O14810, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000168993, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116028, 39 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		O14810

Database of interacting proteins

More...DIPi		DIP-56109N

Protein interaction database and analysis system

More...IntActi		O14810, 12 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000305613

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O14810, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1134
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O14810

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 60DisorderedSequence analysisAdd BLAST60
Regioni48 – 70Interaction with the SNARE complexBy similarityAdd BLAST23
Regioni74 – 113DisorderedSequence analysisAdd BLAST40

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili29 – 69Sequence analysisAdd BLAST41

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi18 – 60Basic and acidic residuesSequence analysisAdd BLAST43

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the complexin/synaphin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S3I2, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182938

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O14810

Identification of Orthologs from Complete Genome Data

More...OMAi		VMKFIPT

Database of Orthologous Groups

More...OrthoDBi		1556534at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O14810

TreeFam database of animal gene trees

More...TreeFami		TF315172

Family and domain databases

Database of protein disorder

More...DisProti		DP02360

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR008849, Synaphin

The PANTHER Classification System

More...PANTHERi		PTHR16705, PTHR16705, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05835, Synaphin, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O14810-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEFVMKQALG GATKDMGKML GGDEEKDPDA AKKEEERQEA LRQAEEERKA 
        60         70         80         90        100
KYAKMEAERE AVRQGIRDKY GIKKKEEREA EAQAAMEANS EGSLTRPKKA 
       110        120        130 
IPPGCGDEVE EEDESILDTV IKYLPGPLQD MLKK
Length:134
Mass (Da):15,030
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA7A52F17F10D28A4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RI11D6RI11_HUMAN
Complexin-1
CPLX1
113Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RAG3D6RAG3_HUMAN
Complexin-1
CPLX1
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_080795105 – 134Missing in DEE63. 1 PublicationAdd BLAST30
Natural variantiVAR_080796108 – 134Missing in DEE63. 1 PublicationAdd BLAST27
Natural variantiVAR_080797128L → M in DEE63; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs371709824EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF022383 mRNA Translation: AAB72108.1
KJ534815 mRNA Translation: AHW56455.1
BT007029 mRNA Translation: AAP35676.1
AB593095 mRNA Translation: BAJ84035.1
AK311921 mRNA Translation: BAG34862.1
AC139887 Genomic DNA No translation available.
CH471131 Genomic DNA Translation: EAW82648.1
CH471131 Genomic DNA Translation: EAW82649.1
BC002471 mRNA Translation: AAH02471.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS46995.1

NCBI Reference Sequences

More...RefSeqi		NP_006642.1, NM_006651.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000304062; ENSP00000305613; ENSG00000168993

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10815

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10815

UCSC genome browser

More...UCSCi		uc003gbi.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022383 mRNA Translation: AAB72108.1
KJ534815 mRNA Translation: AHW56455.1
BT007029 mRNA Translation: AAP35676.1
AB593095 mRNA Translation: BAJ84035.1
AK311921 mRNA Translation: BAG34862.1
AC139887 Genomic DNA No translation available.
CH471131 Genomic DNA Translation: EAW82648.1
CH471131 Genomic DNA Translation: EAW82649.1
BC002471 mRNA Translation: AAH02471.1
CCDSiCCDS46995.1
RefSeqiNP_006642.1, NM_006651.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3RK3X-ray3.50E26-83[»]
3RL0X-ray3.80g/h/i/j/k/l/m/n26-83[»]
SMRiO14810
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116028, 39 interactors
CORUMiO14810
DIPiDIP-56109N
IntActiO14810, 12 interactors
STRINGi9606.ENSP00000305613

PTM databases

iPTMnetiO14810
PhosphoSitePlusiO14810

Genetic variation databases

BioMutaiCPLX1

Proteomic databases

EPDiO14810
MassIVEiO14810
MaxQBiO14810
PaxDbiO14810
PeptideAtlasiO14810
PRIDEiO14810
ProteomicsDBi48251

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		22160, 174 antibodies

The DNASU plasmid repository

More...DNASUi		10815

Genome annotation databases

EnsembliENST00000304062; ENSP00000305613; ENSG00000168993
GeneIDi10815
KEGGihsa:10815
UCSCiuc003gbi.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10815
DisGeNETi10815

GeneCards: human genes, protein and diseases

More...GeneCardsi		CPLX1
HGNCiHGNC:2309, CPLX1
HPAiENSG00000168993, Tissue enriched (brain)
MalaCardsiCPLX1
MIMi605032, gene
617976, phenotype
neXtProtiNX_O14810
OpenTargetsiENSG00000168993
Orphaneti352582, Familial infantile myoclonic epilepsy
280, Wolf-Hirschhorn syndrome
PharmGKBiPA26826
VEuPathDBiHostDB:ENSG00000168993

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S3I2, Eukaryota
GeneTreeiENSGT00950000182938
InParanoidiO14810
OMAiVMKFIPT
OrthoDBi1556534at2759
PhylomeDBiO14810
TreeFamiTF315172

Enzyme and pathway databases

PathwayCommonsiO14810
ReactomeiR-HSA-181429, Serotonin Neurotransmitter Release Cycle
R-HSA-181430, Norepinephrine Neurotransmitter Release Cycle
R-HSA-210500, Glutamate Neurotransmitter Release Cycle
R-HSA-212676, Dopamine Neurotransmitter Release Cycle
R-HSA-264642, Acetylcholine Neurotransmitter Release Cycle
R-HSA-888590, GABA synthesis, release, reuptake and degradation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10815, 5 hits in 1006 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CPLX1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10815
PharosiO14810, Tbio

Protein Ontology

More...PROi		PR:O14810
RNActiO14810, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000168993, Expressed in lateral nuclear group of thalamus and 153 other tissues
ExpressionAtlasiO14810, baseline and differential
GenevisibleiO14810, HS

Family and domain databases

DisProtiDP02360
InterProiView protein in InterPro
IPR008849, Synaphin
PANTHERiPTHR16705, PTHR16705, 1 hit
PfamiView protein in Pfam
PF05835, Synaphin, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCPLX1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O14810
Secondary accession number(s): A6NI80
, B2R4R5, D3DVN3, F1T0G1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: September 29, 2021
This is version 156 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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