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Protein

Ras-related protein M-Ras

Gene

MRAS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Weakly activates the MAP kinase pathway.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi20 – 27GTPBy similarity8
Nucleotide bindingi67 – 71GTPBy similarity5
Nucleotide bindingi126 – 129GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: ProtInc
  • GTP binding Source: UniProtKB-KW
  • GTP-dependent protein binding Source: UniProtKB

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiO14807
SIGNORiO14807

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein M-Ras
Alternative name(s):
Ras-related protein R-Ras3
Gene namesi
Name:MRAS
Synonyms:RRAS3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000158186.12
HGNCiHGNC:7227 MRAS
MIMi608435 gene
neXtProtiNX_O14807

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi22808
OpenTargetsiENSG00000158186
PharmGKBiPA30932

Polymorphism and mutation databases

BioMutaiMRAS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000826541 – 205Ras-related protein M-RasAdd BLAST205
PropeptideiPRO_0000281304206 – 208Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei205Cysteine methyl esterBy similarity1
Lipidationi205S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiO14807
PaxDbiO14807
PeptideAtlasiO14807
PRIDEiO14807
ProteomicsDBi48250

PTM databases

iPTMnetiO14807
PhosphoSitePlusiO14807

Expressioni

Tissue specificityi

Expression highly restricted to the brain and heart.

Inductioni

By IL9/interleukin-9, but not by IL2/interleukin-2 or IL4/interleukin-4.

Gene expression databases

BgeeiENSG00000158186 Expressed in 212 organ(s), highest expression level in heart left ventricle
CleanExiHS_MRAS
ExpressionAtlasiO14807 baseline and differential
GenevisibleiO14807 HS

Organism-specific databases

HPAiHPA042728

Interactioni

Subunit structurei

Interacts with RGL3. Interacts (active GTP-bound form preferentially) with RGS14 (By similarity). Forms a multiprotein complex with SHOC2, Raf (RAF1) and protein phosphatase 1 (PPP1CA, PPP1CB and PPP1CC).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116486, 12 interactors
DIPiDIP-35406N
IntActiO14807, 4 interactors
MINTiO14807
STRINGi9606.ENSP00000289104

Structurei

3D structure databases

ProteinModelPortaliO14807
SMRiO14807
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 50Effector region9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi185 – 191Poly-Lys7

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000133672
HOGENOMiHOG000233973
HOVERGENiHBG009351
InParanoidiO14807
KOiK07831
OMAiWVIMDVL
OrthoDBiEOG091G0UAU
PhylomeDBiO14807
TreeFamiTF312796

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O14807-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATSAVPSDN LPTYKLVVVG DGGVGKSALT IQFFQKIFVP DYDPTIEDSY
60 70 80 90 100
LKHTEIDNQW AILDVLDTAG QEEFSAMREQ YMRTGDGFLI VYSVTDKASF
110 120 130 140 150
EHVDRFHQLI LRVKDRESFP MILVANKVDL MHLRKITREQ GKEMATKHNI
160 170 180 190 200
PYIETSAKDP PLNVDKAFHD LVRVIRQQIP EKSQKKKKKT KWRGDRATGT

HKLQCVIL
Length:208
Mass (Da):23,846
Last modified:August 1, 1998 - v2
Checksum:i0B2B55AFA96B3EC4
GO
Isoform 2 (identifier: O14807-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: Missing.

Show »
Length:132
Mass (Da):15,542
Checksum:i4FC12B4978F7826D
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J8Q6C9J8Q6_HUMAN
Ras-related protein M-Ras
MRAS
107Annotation score:
C9J601C9J601_HUMAN
Ras-related protein M-Ras
MRAS
23Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0447921 – 76Missing in isoform 2. 2 PublicationsAdd BLAST76

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022080 mRNA Translation: AAC52085.1
AF043938 mRNA Translation: AAD02287.1
AF493918 mRNA Translation: AAM12632.1
AK295640 mRNA Translation: BAG58512.1
AK316071 mRNA Translation: BAH14442.1
BT020057 mRNA Translation: AAV38860.1
AC022337 Genomic DNA No translation available.
AC022497 Genomic DNA No translation available.
BC047690 mRNA No translation available.
CCDSiCCDS3100.1 [O14807-1]
CCDS58855.1 [O14807-2]
RefSeqiNP_001078518.1, NM_001085049.2 [O14807-1]
NP_001239019.1, NM_001252090.1 [O14807-1]
NP_001239020.1, NM_001252091.1 [O14807-2]
NP_001239021.1, NM_001252092.1 [O14807-2]
NP_001239022.1, NM_001252093.1 [O14807-2]
NP_036351.3, NM_012219.4 [O14807-1]
XP_005247285.1, XM_005247228.1 [O14807-1]
XP_016861376.1, XM_017005887.1 [O14807-1]
UniGeneiHs.527021
Hs.735125

Genome annotation databases

EnsembliENST00000289104; ENSP00000289104; ENSG00000158186 [O14807-1]
ENST00000423968; ENSP00000389682; ENSG00000158186 [O14807-1]
ENST00000464896; ENSP00000419582; ENSG00000158186 [O14807-2]
ENST00000474559; ENSP00000418356; ENSG00000158186 [O14807-1]
ENST00000614350; ENSP00000484586; ENSG00000158186 [O14807-2]
ENST00000621127; ENSP00000481637; ENSG00000158186 [O14807-2]
GeneIDi22808
KEGGihsa:22808
UCSCiuc011bmi.3 human [O14807-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022080 mRNA Translation: AAC52085.1
AF043938 mRNA Translation: AAD02287.1
AF493918 mRNA Translation: AAM12632.1
AK295640 mRNA Translation: BAG58512.1
AK316071 mRNA Translation: BAH14442.1
BT020057 mRNA Translation: AAV38860.1
AC022337 Genomic DNA No translation available.
AC022497 Genomic DNA No translation available.
BC047690 mRNA No translation available.
CCDSiCCDS3100.1 [O14807-1]
CCDS58855.1 [O14807-2]
RefSeqiNP_001078518.1, NM_001085049.2 [O14807-1]
NP_001239019.1, NM_001252090.1 [O14807-1]
NP_001239020.1, NM_001252091.1 [O14807-2]
NP_001239021.1, NM_001252092.1 [O14807-2]
NP_001239022.1, NM_001252093.1 [O14807-2]
NP_036351.3, NM_012219.4 [O14807-1]
XP_005247285.1, XM_005247228.1 [O14807-1]
XP_016861376.1, XM_017005887.1 [O14807-1]
UniGeneiHs.527021
Hs.735125

3D structure databases

ProteinModelPortaliO14807
SMRiO14807
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116486, 12 interactors
DIPiDIP-35406N
IntActiO14807, 4 interactors
MINTiO14807
STRINGi9606.ENSP00000289104

PTM databases

iPTMnetiO14807
PhosphoSitePlusiO14807

Polymorphism and mutation databases

BioMutaiMRAS

Proteomic databases

EPDiO14807
PaxDbiO14807
PeptideAtlasiO14807
PRIDEiO14807
ProteomicsDBi48250

Protocols and materials databases

DNASUi22808
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000289104; ENSP00000289104; ENSG00000158186 [O14807-1]
ENST00000423968; ENSP00000389682; ENSG00000158186 [O14807-1]
ENST00000464896; ENSP00000419582; ENSG00000158186 [O14807-2]
ENST00000474559; ENSP00000418356; ENSG00000158186 [O14807-1]
ENST00000614350; ENSP00000484586; ENSG00000158186 [O14807-2]
ENST00000621127; ENSP00000481637; ENSG00000158186 [O14807-2]
GeneIDi22808
KEGGihsa:22808
UCSCiuc011bmi.3 human [O14807-1]

Organism-specific databases

CTDi22808
DisGeNETi22808
EuPathDBiHostDB:ENSG00000158186.12
GeneCardsiMRAS
HGNCiHGNC:7227 MRAS
HPAiHPA042728
MIMi608435 gene
neXtProtiNX_O14807
OpenTargetsiENSG00000158186
PharmGKBiPA30932
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000133672
HOGENOMiHOG000233973
HOVERGENiHBG009351
InParanoidiO14807
KOiK07831
OMAiWVIMDVL
OrthoDBiEOG091G0UAU
PhylomeDBiO14807
TreeFamiTF312796

Enzyme and pathway databases

SignaLinkiO14807
SIGNORiO14807

Miscellaneous databases

ChiTaRSiMRAS human
GeneWikiiMRAS
GenomeRNAii22808
PROiPR:O14807
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158186 Expressed in 212 organ(s), highest expression level in heart left ventricle
CleanExiHS_MRAS
ExpressionAtlasiO14807 baseline and differential
GenevisibleiO14807 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRASM_HUMAN
AccessioniPrimary (citable) accession number: O14807
Secondary accession number(s): B4DIK0, Q86WX8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: September 12, 2018
This is version 178 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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