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Protein

Trace amine-associated receptor 5

Gene

TAAR5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Olfactory receptor specific for trimethylamine, a trace amine. Also activated at lower level by dimethylethylamine. Trimethylamine is a bacterial metabolite found in some animal odors, and to humans it is a repulsive odor associated with bad breath and spoiled food. This receptor is probably mediated by the G(s)-class of G-proteins which activate adenylate cyclase.1 Publication

Miscellaneous

Polymorphic variants of this gene are not associated with specific anosmia for trimethylamine.1 Publication

GO - Molecular functioni

  • G protein-coupled receptor activity Source: GDB
  • trace-amine receptor activity Source: GO_Central
  • trimethylamine receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-375280 Amine ligand-binding receptors
R-HSA-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Trace amine-associated receptor 5
Short name:
TaR-5
Short name:
Trace amine receptor 5
Short name:
hTaar5
Alternative name(s):
Putative neurotransmitter receptor
Gene namesi
Name:TAAR5
Synonyms:PNR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000135569.4
HGNCiHGNC:30236 TAAR5
MIMi607405 gene
neXtProtiNX_O14804

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34ExtracellularSequence analysisAdd BLAST34
Transmembranei35 – 55Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini56 – 70CytoplasmicSequence analysisAdd BLAST15
Transmembranei71 – 91Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini92 – 109ExtracellularSequence analysisAdd BLAST18
Transmembranei110 – 130Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini131 – 154CytoplasmicSequence analysisAdd BLAST24
Transmembranei155 – 175Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini176 – 204ExtracellularSequence analysisAdd BLAST29
Transmembranei205 – 225Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini226 – 253CytoplasmicSequence analysisAdd BLAST28
Transmembranei254 – 274Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini275 – 284ExtracellularSequence analysis10
Transmembranei285 – 307Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini308 – 337CytoplasmicSequence analysisAdd BLAST30

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9038
OpenTargetsiENSG00000135569
PharmGKBiPA142670843

Chemistry databases

ChEMBLiCHEMBL3714046

Polymorphism and mutation databases

BioMutaiTAAR5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701541 – 337Trace amine-associated receptor 5Add BLAST337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi21N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi99 ↔ 192PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO14804
PeptideAtlasiO14804
PRIDEiO14804
ProteomicsDBi48249

PTM databases

PhosphoSitePlusiO14804

Expressioni

Tissue specificityi

Expressed almost exclusively in skeletal muscle and selected areas of the brain, such amygdala, hippocampus, caudate nucleus, thalamus and hypothalamus. Weak expression is also find in substantia nigra.1 Publication

Gene expression databases

BgeeiENSG00000135569 Expressed in 2 organ(s), highest expression level in blood
CleanExiHS_TAAR5
GenevisibleiO14804 HS

Organism-specific databases

HPAiHPA051703

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000258034

Structurei

3D structure databases

ProteinModelPortaliO14804
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00890000139340
HOGENOMiHOG000239243
HOVERGENiHBG106962
InParanoidiO14804
KOiK05051
OMAiHCAICDP
OrthoDBiEOG091G06VI
PhylomeDBiO14804
TreeFamiTF343107

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR009132 TAAR_fam
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01830 TRACEAMINER
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O14804-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRAVFIQGAE EHPAAFCYQV NGSCPRTVHT LGIQLVIYLA CAAGMLIIVL
60 70 80 90 100
GNVFVAFAVS YFKALHTPTN FLLLSLALAD MFLGLLVLPL STIRSVESCW
110 120 130 140 150
FFGDFLCRLH TYLDTLFCLT SIFHLCFISI DRHCAICDPL LYPSKFTVRV
160 170 180 190 200
ALRYILAGWG VPAAYTSLFL YTDVVETRLS QWLEEMPCVG SCQLLLNKFW
210 220 230 240 250
GWLNFPLFFV PCLIMISLYV KIFVVATRQA QQITTLSKSL AGAAKHERKA
260 270 280 290 300
AKTLGIAVGI YLLCWLPFTI DTMVDSLLHF ITPPLVFDIF IWFAYFNSAC
310 320 330
NPIIYVFSYQ WFRKALKLTL SQKVFSPQTR TVDLYQE
Length:337
Mass (Da):38,242
Last modified:November 22, 2005 - v2
Checksum:i251DB41A13A5535A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16F → L in AAH95541 (PubMed:15489334).Curated1
Sequence conflicti40A → T in AAC39581 (PubMed:9464258).Curated1
Sequence conflicti80D → N in AAH69171 (PubMed:15489334).Curated1
Sequence conflicti257A → V in AAC39581 (PubMed:9464258).Curated1
Sequence conflicti332V → A in AAH95541 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055923272T → M. Corresponds to variant dbSNP:rs34746740Ensembl.1
Natural variantiVAR_055924330R → C. Corresponds to variant dbSNP:rs35839363Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF021818 mRNA Translation: AAC39581.1
AY702306 Genomic DNA Translation: AAV70123.1
FJ372547 Genomic DNA Translation: ACP18682.1
AL513524 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48025.1
BC069171 mRNA Translation: AAH69171.1
BC095541 mRNA Translation: AAH95541.1
BC112209 mRNA Translation: AAI12210.1
BC112211 mRNA Translation: AAI12212.1
CCDSiCCDS5156.1
PIRiJC5832
RefSeqiNP_003958.2, NM_003967.2
UniGeneiHs.248198

Genome annotation databases

EnsembliENST00000258034; ENSP00000258034; ENSG00000135569
GeneIDi9038
KEGGihsa:9038
UCSCiuc003qdk.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF021818 mRNA Translation: AAC39581.1
AY702306 Genomic DNA Translation: AAV70123.1
FJ372547 Genomic DNA Translation: ACP18682.1
AL513524 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48025.1
BC069171 mRNA Translation: AAH69171.1
BC095541 mRNA Translation: AAH95541.1
BC112209 mRNA Translation: AAI12210.1
BC112211 mRNA Translation: AAI12212.1
CCDSiCCDS5156.1
PIRiJC5832
RefSeqiNP_003958.2, NM_003967.2
UniGeneiHs.248198

3D structure databases

ProteinModelPortaliO14804
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000258034

Chemistry databases

ChEMBLiCHEMBL3714046

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiO14804

Polymorphism and mutation databases

BioMutaiTAAR5

Proteomic databases

PaxDbiO14804
PeptideAtlasiO14804
PRIDEiO14804
ProteomicsDBi48249

Protocols and materials databases

DNASUi9038
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258034; ENSP00000258034; ENSG00000135569
GeneIDi9038
KEGGihsa:9038
UCSCiuc003qdk.3 human

Organism-specific databases

CTDi9038
DisGeNETi9038
EuPathDBiHostDB:ENSG00000135569.4
GeneCardsiTAAR5
HGNCiHGNC:30236 TAAR5
HPAiHPA051703
MIMi607405 gene
neXtProtiNX_O14804
OpenTargetsiENSG00000135569
PharmGKBiPA142670843
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00890000139340
HOGENOMiHOG000239243
HOVERGENiHBG106962
InParanoidiO14804
KOiK05051
OMAiHCAICDP
OrthoDBiEOG091G06VI
PhylomeDBiO14804
TreeFamiTF343107

Enzyme and pathway databases

ReactomeiR-HSA-375280 Amine ligand-binding receptors
R-HSA-418555 G alpha (s) signalling events

Miscellaneous databases

GeneWikiiTAAR5
GenomeRNAii9038
PROiPR:O14804
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135569 Expressed in 2 organ(s), highest expression level in blood
CleanExiHS_TAAR5
GenevisibleiO14804 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR009132 TAAR_fam
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01830 TRACEAMINER
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTAAR5_HUMAN
AccessioniPrimary (citable) accession number: O14804
Secondary accession number(s): D8KZS1
, Q2M1V1, Q4VBL1, Q5VUQ3, Q6NTA8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: November 7, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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