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Protein

Tumor necrosis factor receptor superfamily member 10C

Gene

TNFRSF10C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.

GO - Molecular functioni

  • TRAIL binding Source: InterPro
  • transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands
SIGNORiO14798

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 10C
Alternative name(s):
Antagonist decoy receptor for TRAIL/Apo-2L
Decoy TRAIL receptor without death domain
Decoy receptor 1
Short name:
DcR1
Lymphocyte inhibitor of TRAIL
TNF-related apoptosis-inducing ligand receptor 3
Short name:
TRAIL receptor 3
Short name:
TRAIL-R3
TRAIL receptor without an intracellular domain
CD_antigen: CD263
Gene namesi
Name:TNFRSF10C
Synonyms:DCR1, LIT, TRAILR3, TRID
ORF Names:UNQ321/PRO366
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000173535.13
HGNCiHGNC:11906 TNFRSF10C
MIMi603613 gene
neXtProtiNX_O14798

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8794
OpenTargetsiENSG00000173535
PharmGKBiPA36599

Polymorphism and mutation databases

BioMutaiTNFRSF10C

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 252 PublicationsAdd BLAST25
ChainiPRO_000003458226 – 236Tumor necrosis factor receptor superfamily member 10CAdd BLAST211
PropeptideiPRO_0000034583237 – 259Removed in mature formSequence analysisAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 66PROSITE-ProRule annotation
Disulfide bondi69 ↔ 85PROSITE-ProRule annotation
Glycosylationi77N-linked (GlcNAc...) (high mannose) asparagineSequence analysis1
Disulfide bondi88 ↔ 101PROSITE-ProRule annotation
Disulfide bondi91 ↔ 109PROSITE-ProRule annotation
Disulfide bondi111 ↔ 125PROSITE-ProRule annotation
Disulfide bondi128 ↔ 141PROSITE-ProRule annotation
Disulfide bondi131 ↔ 149PROSITE-ProRule annotation
Glycosylationi140N-linked (GlcNAc...) (high mannose) asparagineSequence analysis1
Glycosylationi156N-linked (GlcNAc...) (high mannose) asparagineSequence analysis1
Lipidationi236GPI-anchor amidated alanineSequence analysis1

Post-translational modificationi

N-glycosylated and O-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiO14798
PeptideAtlasiO14798
PRIDEiO14798
ProteomicsDBi48247

PTM databases

iPTMnetiO14798
PhosphoSitePlusiO14798

Expressioni

Tissue specificityi

Higher expression in normal tissues than in tumor cell lines. Highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung and heart.

Gene expression databases

BgeeiENSG00000173535 Expressed in 197 organ(s), highest expression level in blood
CleanExiHS_TNFRSF10C
ExpressionAtlasiO14798 baseline and differential
GenevisibleiO14798 HS

Organism-specific databases

HPAiCAB025635

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114322, 63 interactors
DIPiDIP-6242N
IntActiO14798, 31 interactors
STRINGi9606.ENSP00000349324

Structurei

3D structure databases

ProteinModelPortaliO14798
SMRiO14798
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati29 – 66TNFR-Cys 1Add BLAST38
Repeati69 – 109TNFR-Cys 2Add BLAST41
Repeati110 – 149TNFR-Cys 3Add BLAST40
Repeati162 – 176TAPE 1Add BLAST15
Repeati177 – 191TAPE 2Add BLAST15
Repeati192 – 206TAPE 3Add BLAST15
Repeati207 – 221TAPE 4Add BLAST15
Repeati222 – 236TAPE 5Add BLAST15

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410JFKD Eukaryota
ENOG410Y7QF LUCA
GeneTreeiENSGT00730000110985
HOVERGENiHBG061470
InParanoidiO14798
KOiK22701
OMAiHYLSCTI
OrthoDBiEOG091G0MOV
PhylomeDBiO14798
TreeFamiTF333916

Family and domain databases

CDDicd10580 TNFRSF10, 1 hit
InterProiView protein in InterPro
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR020465 TNFR_10
IPR034024 TNFRSF10_N
PfamiView protein in Pfam
PF00020 TNFR_c6, 2 hits
PRINTSiPR01956 TNFACTORR10
SMARTiView protein in SMART
SM00208 TNFR, 2 hits
PROSITEiView protein in PROSITE
PS00652 TNFR_NGFR_1, 2 hits
PS50050 TNFR_NGFR_2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O14798-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARIPKTLKF VVVIVAVLLP VLAYSATTAR QEEVPQQTVA PQQQRHSFKG
60 70 80 90 100
EECPAGSHRS EHTGACNPCT EGVDYTNASN NEPSCFPCTV CKSDQKHKSS
110 120 130 140 150
CTMTRDTVCQ CKEGTFRNEN SPEMCRKCSR CPSGEVQVSN CTSWDDIQCV
160 170 180 190 200
EEFGANATVE TPAAEETMNT SPGTPAPAAE ETMNTSPGTP APAAEETMTT
210 220 230 240 250
SPGTPAPAAE ETMTTSPGTP APAAEETMIT SPGTPASSHY LSCTIVGIIV

LIVLLIVFV
Length:259
Mass (Da):27,407
Last modified:November 24, 2009 - v3
Checksum:i40CBF7FCEEAE4C69
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RJI1E5RJI1_HUMAN
Tumor necrosis factor receptor supe...
TNFRSF10C
67Annotation score:

Sequence cautioni

The sequence AAB71413 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAC05593 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAQ88648 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti119E → V in AAB81181 (PubMed:9373179).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_046534199T → N. Corresponds to variant dbSNP:rs12550828Ensembl.1
Natural variantiVAR_046535229I → T8 PublicationsCorresponds to variant dbSNP:rs9644063Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020502 mRNA Translation: AAB71413.1 Different initiation.
AF014794 mRNA Translation: AAC05593.1 Different initiation.
AF012629 mRNA Translation: AAB67110.1
AF012536 mRNA Translation: AAB67104.1
AF016267 mRNA Translation: AAB81181.1
AF033854 mRNA Translation: AAB87506.1
AY358281 mRNA Translation: AAQ88648.1 Different initiation.
CR541857 mRNA Translation: CAG46655.1
AC107959 Genomic DNA No translation available.
BC125041 mRNA Translation: AAI25042.1
BC125042 mRNA Translation: AAI25043.1
CCDSiCCDS6037.1
RefSeqiNP_003832.2, NM_003841.4
UniGeneiHs.655801

Genome annotation databases

EnsembliENST00000356864; ENSP00000349324; ENSG00000173535
GeneIDi8794
KEGGihsa:8794
UCSCiuc003xcy.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020502 mRNA Translation: AAB71413.1 Different initiation.
AF014794 mRNA Translation: AAC05593.1 Different initiation.
AF012629 mRNA Translation: AAB67110.1
AF012536 mRNA Translation: AAB67104.1
AF016267 mRNA Translation: AAB81181.1
AF033854 mRNA Translation: AAB87506.1
AY358281 mRNA Translation: AAQ88648.1 Different initiation.
CR541857 mRNA Translation: CAG46655.1
AC107959 Genomic DNA No translation available.
BC125041 mRNA Translation: AAI25042.1
BC125042 mRNA Translation: AAI25043.1
CCDSiCCDS6037.1
RefSeqiNP_003832.2, NM_003841.4
UniGeneiHs.655801

3D structure databases

ProteinModelPortaliO14798
SMRiO14798
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114322, 63 interactors
DIPiDIP-6242N
IntActiO14798, 31 interactors
STRINGi9606.ENSP00000349324

PTM databases

iPTMnetiO14798
PhosphoSitePlusiO14798

Polymorphism and mutation databases

BioMutaiTNFRSF10C

Proteomic databases

PaxDbiO14798
PeptideAtlasiO14798
PRIDEiO14798
ProteomicsDBi48247

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356864; ENSP00000349324; ENSG00000173535
GeneIDi8794
KEGGihsa:8794
UCSCiuc003xcy.4 human

Organism-specific databases

CTDi8794
DisGeNETi8794
EuPathDBiHostDB:ENSG00000173535.13
GeneCardsiTNFRSF10C
HGNCiHGNC:11906 TNFRSF10C
HPAiCAB025635
MIMi603613 gene
neXtProtiNX_O14798
OpenTargetsiENSG00000173535
PharmGKBiPA36599
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JFKD Eukaryota
ENOG410Y7QF LUCA
GeneTreeiENSGT00730000110985
HOVERGENiHBG061470
InParanoidiO14798
KOiK22701
OMAiHYLSCTI
OrthoDBiEOG091G0MOV
PhylomeDBiO14798
TreeFamiTF333916

Enzyme and pathway databases

ReactomeiR-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands
SIGNORiO14798

Miscellaneous databases

ChiTaRSiTNFRSF10C human
GeneWikiiTNFRSF10C
GenomeRNAii8794
PROiPR:O14798
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173535 Expressed in 197 organ(s), highest expression level in blood
CleanExiHS_TNFRSF10C
ExpressionAtlasiO14798 baseline and differential
GenevisibleiO14798 HS

Family and domain databases

CDDicd10580 TNFRSF10, 1 hit
InterProiView protein in InterPro
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR020465 TNFR_10
IPR034024 TNFRSF10_N
PfamiView protein in Pfam
PF00020 TNFR_c6, 2 hits
PRINTSiPR01956 TNFACTORR10
SMARTiView protein in SMART
SM00208 TNFR, 2 hits
PROSITEiView protein in PROSITE
PS00652 TNFR_NGFR_1, 2 hits
PS50050 TNFR_NGFR_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTR10C_HUMAN
AccessioniPrimary (citable) accession number: O14798
Secondary accession number(s): O14755
, Q08AS6, Q6FH98, Q6UXM5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 24, 2009
Last modified: November 7, 2018
This is version 156 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  5. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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Main funding by: National Institutes of Health

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