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UniProtKB - O14787 (TNPO2_HUMAN)

Entry version 166 (10 Feb 2021)
Sequence version 3 (24 Nov 2009)
Previous versions | rss
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Protein

Transportin-2

Gene

TNPO2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O14787

Protein family/group databases

Transport Classification Database

More...TCDBi		1.I.1.1.3, the nuclear pore complex (npc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transportin-2
Alternative name(s):
Karyopherin beta-2b
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNPO2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:19998, TNPO2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603002, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O14787

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000105576.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		30000

Open Targets

More...OpenTargetsi		ENSG00000105576

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134921349

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O14787, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TNPO2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001207671 – 897Transportin-2Add BLAST897

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei862N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O14787

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O14787

MaxQB - The MaxQuant DataBase

More...MaxQBi		O14787

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O14787

PeptideAtlas

More...PeptideAtlasi		O14787

PRoteomics IDEntifications database

More...PRIDEi		O14787

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		48235 [O14787-1]
48236 [O14787-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O14787

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O14787

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000105576, Expressed in temporal lobe and 257 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O14787, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O14787, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000105576, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
O14787
With#Exp.IntAct
APIP [Q96GX9]4EBI-431907,EBI-359248
C1orf94 [Q6P1W5]3EBI-431907,EBI-946029
CAMK2D [Q13557]4EBI-431907,EBI-351018
EXOC5 [O00471]4EBI-431907,EBI-949824
HEL-S-101 [V9HW27]3EBI-431907,EBI-10178933
KLHL2 [O95198]4EBI-431907,EBI-746999
NME1 [P15531]3EBI-431907,EBI-741141
PNMA5 [Q96PV4]3EBI-431907,EBI-10171633
TERF1 [P54274]2EBI-431907,EBI-710997
Isoform 2 [O14787-2]
With#Exp.IntAct
BEND7 - isoform 2 [Q8N7W2-2]3EBI-12076664,EBI-10181188
BIRC7 [Q96CA5]3EBI-12076664,EBI-517623
BLMH [Q13867]3EBI-12076664,EBI-718504
C12orf40 [Q86WS4]3EBI-12076664,EBI-10286004
CAMK2B - isoform 2 [Q13554-3]3EBI-12076664,EBI-11523526
CAMK2G - isoform 5 [Q13555-5]3EBI-12076664,EBI-12020154
CTAG1B [P78358]3EBI-12076664,EBI-1188472
FH [P07954]3EBI-12076664,EBI-1050358
FTO - isoform 2 [Q9C0B1-2]3EBI-12076664,EBI-18138793
FUCA2 [Q9BTY2]3EBI-12076664,EBI-9050116
GCH1 [P30793]3EBI-12076664,EBI-958183
GSC2 [O15499]3EBI-12076664,EBI-19954058
KLHL20 [Q9BS75]3EBI-12076664,EBI-10693436
KLHL3 [Q9UH77]3EBI-12076664,EBI-8524663
KLK6 [Q92876]3EBI-12076664,EBI-2432309
KRT75 [O95678]3EBI-12076664,EBI-2949715
KRTAP8-1 [Q8IUC2]3EBI-12076664,EBI-10261141
OTX2 - isoform 2 [P32243-2]3EBI-12076664,EBI-9087860
PACSIN3 [Q9UKS6]3EBI-12076664,EBI-77926
PDLIM7 [Q9NR12]3EBI-12076664,EBI-350517
PINX1 [Q96BK5]3EBI-12076664,EBI-721782
POU6F2 [P78424]3EBI-12076664,EBI-12029004
PRMT8 [Q9NR22]3EBI-12076664,EBI-745545
PYCR1 [P32322]3EBI-12076664,EBI-848624
RAN [P62826]3EBI-12076664,EBI-286642
RBM45 - isoform 3 [Q8IUH3-3]3EBI-12076664,EBI-10964453
RPRD1B [Q9NQG5]3EBI-12076664,EBI-747925
SERTAD3 [Q9UJW9]3EBI-12076664,EBI-748621
SF1 - isoform 4 [Q15637-4]3EBI-12076664,EBI-12223157
TBX2 [Q13207]3EBI-12076664,EBI-2853051
THAP6 [Q8TBB0]3EBI-12076664,EBI-3925505
TRIM8 [Q9BZR9]3EBI-12076664,EBI-2340370
ZBTB32 [A0A0C4DGF1]3EBI-12076664,EBI-10188476
ZC2HC1C - isoform 2 [Q53FD0-2]3EBI-12076664,EBI-14104088

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119024, 121 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		O14787

Protein interaction database and analysis system

More...IntActi		O14787, 51 interactors

Molecular INTeraction database

More...MINTi		O14787

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000407182

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O14787, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O14787

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati9 – 36HEAT 1By similarityAdd BLAST28
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 99Importin N-terminalAdd BLAST69
Repeati41 – 79HEAT 2By similarityAdd BLAST39
Repeati88 – 121HEAT 3By similarityAdd BLAST34
Repeati127 – 164HEAT 4By similarityAdd BLAST38
Repeati171 – 201HEAT 5By similarityAdd BLAST31
Repeati214 – 241HEAT 6By similarityAdd BLAST28
Repeati253 – 280HEAT 7By similarityAdd BLAST28
Repeati296 – 386HEAT 8By similarityAdd BLAST91
Repeati394 – 422HEAT 9By similarityAdd BLAST29
Repeati434 – 461HEAT 10By similarityAdd BLAST28
Repeati475 – 508HEAT 11By similarityAdd BLAST34
Repeati516 – 549HEAT 12By similarityAdd BLAST34
Repeati557 – 595HEAT 13By similarityAdd BLAST39
Repeati603 – 654HEAT 14By similarityAdd BLAST52
Repeati665 – 696HEAT 15By similarityAdd BLAST32
Repeati704 – 737HEAT 16By similarityAdd BLAST34
Repeati745 – 790HEAT 17By similarityAdd BLAST46
Repeati798 – 831HEAT 18By similarityAdd BLAST34
Repeati840 – 871HEAT 19By similarityAdd BLAST32
Repeati874 – 894HEAT 20By similarityAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the importin beta family. Importin beta-2 subfamily.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2023, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156708

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_008136_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O14787

Identification of Orthologs from Complete Genome Data

More...OMAi		INVFTPR

Database for complete collections of gene phylogenies

More...PhylomeDBi		O14787

TreeFam database of animal gene trees

More...TreeFami		TF300825

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016024, ARM-type_fold
IPR001494, Importin-beta_N
IPR040122, Importin_beta

The PANTHER Classification System

More...PANTHERi		PTHR10527, PTHR10527, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03810, IBN_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00913, IBN_N, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O14787-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDWQPDEQGL QQVLQLLKDS QSPNTATQRI VQDKLKQLNQ FPDFNNYLIF 
        60         70         80         90        100
VLTRLKSEDE PTRSLSGLIL KNNVKAHYQS FPPPVADFIK QECLNNIGDA 
       110        120        130        140        150
SSLIRATIGI LITTIASKGE LQMWPELLPQ LCNLLNSEDY NTCEGAFGAL 
       160        170        180        190        200
QKICEDSSEL LDSDALNRPL NIMIPKFLQF FKHCSPKIRS HAIACVNQFI 
       210        220        230        240        250
MDRAQALMDN IDTFIEHLFA LAVDDDPEVR KNVCRALVML LEVRIDRLIP 
       260        270        280        290        300
HMHSIIQYML QRTQDHDENV ALEACEFWLT LAEQPICKEV LASHLVQLIP 
       310        320        330        340        350
ILVNGMKYSE IDIILLKGDV EEDEAVPDSE QDIKPRFHKS RTVTLPHEAE 
       360        370        380        390        400
RPDGSEDAED DDDDDALSDW NLRKCSAAAL DVLANVFREE LLPHLLPLLK 
       410        420        430        440        450
GLLFHPEWVV KESGILVLGA IAEGCMQGMV PYLPELIPHL IQCLSDKKAL 
       460        470        480        490        500
VRSIACWTLS RYAHWVVSQP PDMHLKPLMT ELLKRILDGN KRVQEAACSA 
       510        520        530        540        550
FATLEEEACT ELVPYLSYIL DTLVFAFGKY QHKNLLILYD AIGTLADSVG 
       560        570        580        590        600
HHLNQPEYIQ KLMPPLIQKW NELKDEDKDL FPLLECLSSV ATALQSGFLP 
       610        620        630        640        650
YCEPVYQRCV TLVQKTLAQA MMYTQHPEQY EAPDKDFMIV ALDLLSGLAE 
       660        670        680        690        700
GLGGHVEQLV ARSNIMTLLF QCMQDSMPEV RQSSFALLGD LTKACFIHVK 
       710        720        730        740        750
PCIAEFMPIL GTNLNPEFIS VCNNATWAIG EICMQMGAEM QPYVQMVLNN 
       760        770        780        790        800
LVEIINRPNT PKTLLENTGR LTSPSAIPAI TIGRLGYVCP QEVAPMLQQF 
       810        820        830        840        850
IRPWCTSLRN IRDNEEKDSA FRGICMMIGV NPGGVVQDFI FFCDAVASWV 
       860        870        880        890 
SPKDDLRDMF YKILHGFKDQ VGEDNWQQFS EQFPPLLKER LAAFYGV
Length:897
Mass (Da):101,388
Last modified:November 24, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i26FE455583D7D35F
GO
Isoform 2 (identifier: O14787-2) [UniParc]FASTAAdd to basket
Also known as: beta2b

The sequence of this isoform differs from the canonical sequence as follows:
     769-778: Missing.

Show »
Length:887
Mass (Da):100,408
Checksum:iAE64FDCE4DA901DB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A075B780A0A075B780_HUMAN
Transportin-2
TNPO2
766Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ELC3K7ELC3_HUMAN
Transportin-2
TNPO2
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ENW1K7ENW1_HUMAN
Transportin-2
TNPO2
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ESC1K7ESC1_HUMAN
Transportin-2
TNPO2
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ESG1K7ESG1_HUMAN
Transportin-2
TNPO2
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ESJ3K7ESJ3_HUMAN
Transportin-2
TNPO2
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EMA3K7EMA3_HUMAN
Transportin-2
TNPO2
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti28Q → H in AAB71349 (Ref. 2) Curated1
Sequence conflicti32Q → R in AAB71349 (Ref. 2) Curated1
Sequence conflicti194A → G in AAB71349 (Ref. 2) Curated1
Sequence conflicti398 – 401LLKG → YQS in AAB83973 (PubMed:9298975).Curated4
Sequence conflicti492R → K in AAB71349 (Ref. 2) Curated1
Sequence conflicti499S → I in AAB71349 (Ref. 2) Curated1
Sequence conflicti507E → K in AAB71349 (Ref. 2) Curated1
Sequence conflicti608R → C in AAB71349 (Ref. 2) Curated1
Sequence conflicti645L → F in AAB71349 (Ref. 2) Curated1
Sequence conflicti646S → T in AAB83973 (PubMed:9298975).Curated1
Sequence conflicti656V → L in AAB83973 (PubMed:9298975).Curated1
Sequence conflicti687L → F in AAB71349 (Ref. 2) Curated1
Sequence conflicti691L → F in AAB71349 (Ref. 2) Curated1
Sequence conflicti696 – 697FI → SS in AAB71349 (Ref. 2) Curated2
Sequence conflicti717E → K in AAB83973 (PubMed:9298975).Curated1
Sequence conflicti812R → Q in AAB83973 (PubMed:9298975).Curated1
Sequence conflicti841F → L in AAB71349 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_069373370W → C Found in a patient with severely delayed development, autism, myopia, strabismus and some dysmorphisms. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_009657769 – 778Missing in isoform 2. 2 Publications10

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF019039 mRNA Translation: AAB83973.1
AF007748 mRNA Translation: AAB71349.1
AC018761 Genomic DNA No translation available.
CH471106 Genomic DNA Translation: EAW84300.1
BC072420 mRNA Translation: AAH72420.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS45991.1 [O14787-1]
CCDS45992.1 [O14787-2]

NCBI Reference Sequences

More...RefSeqi		NP_001129667.1, NM_001136195.1 [O14787-2]
NP_001129668.1, NM_001136196.1 [O14787-1]
NP_038461.2, NM_013433.4 [O14787-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000356861; ENSP00000349321; ENSG00000105576 [O14787-2]
ENST00000425528; ENSP00000407182; ENSG00000105576 [O14787-1]
ENST00000450764; ENSP00000397379; ENSG00000105576 [O14787-2]
ENST00000588216; ENSP00000465625; ENSG00000105576 [O14787-2]
ENST00000592287; ENSP00000468434; ENSG00000105576 [O14787-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		30000

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:30000

UCSC genome browser

More...UCSCi		uc002muo.4, human [O14787-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019039 mRNA Translation: AAB83973.1
AF007748 mRNA Translation: AAB71349.1
AC018761 Genomic DNA No translation available.
CH471106 Genomic DNA Translation: EAW84300.1
BC072420 mRNA Translation: AAH72420.1
CCDSiCCDS45991.1 [O14787-1]
CCDS45992.1 [O14787-2]
RefSeqiNP_001129667.1, NM_001136195.1 [O14787-2]
NP_001129668.1, NM_001136196.1 [O14787-1]
NP_038461.2, NM_013433.4 [O14787-2]

3D structure databases

SMRiO14787
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi119024, 121 interactors
CORUMiO14787
IntActiO14787, 51 interactors
MINTiO14787
STRINGi9606.ENSP00000407182

Protein family/group databases

TCDBi1.I.1.1.3, the nuclear pore complex (npc) family

PTM databases

iPTMnetiO14787
PhosphoSitePlusiO14787

Genetic variation databases

BioMutaiTNPO2

Proteomic databases

jPOSTiO14787
MassIVEiO14787
MaxQBiO14787
PaxDbiO14787
PeptideAtlasiO14787
PRIDEiO14787
ProteomicsDBi48235 [O14787-1]
48236 [O14787-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		26113, 89 antibodies

Genome annotation databases

EnsembliENST00000356861; ENSP00000349321; ENSG00000105576 [O14787-2]
ENST00000425528; ENSP00000407182; ENSG00000105576 [O14787-1]
ENST00000450764; ENSP00000397379; ENSG00000105576 [O14787-2]
ENST00000588216; ENSP00000465625; ENSG00000105576 [O14787-2]
ENST00000592287; ENSP00000468434; ENSG00000105576 [O14787-1]
GeneIDi30000
KEGGihsa:30000
UCSCiuc002muo.4, human [O14787-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		30000
DisGeNETi30000

GeneCards: human genes, protein and diseases

More...GeneCardsi		TNPO2
HGNCiHGNC:19998, TNPO2
HPAiENSG00000105576, Low tissue specificity
MIMi603002, gene
neXtProtiNX_O14787
OpenTargetsiENSG00000105576
PharmGKBiPA134921349
VEuPathDBiHostDB:ENSG00000105576.15

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2023, Eukaryota
GeneTreeiENSGT00940000156708
HOGENOMiCLU_008136_1_0_1
InParanoidiO14787
OMAiINVFTPR
PhylomeDBiO14787
TreeFamiTF300825

Enzyme and pathway databases

PathwayCommonsiO14787

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		30000, 8 hits in 878 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TNPO2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TNPO2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		30000
PharosiO14787, Tbio

Protein Ontology

More...PROi		PR:O14787
RNActiO14787, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000105576, Expressed in temporal lobe and 257 other tissues
ExpressionAtlasiO14787, baseline and differential
GenevisibleiO14787, HS

Family and domain databases

InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR001494, Importin-beta_N
IPR040122, Importin_beta
PANTHERiPTHR10527, PTHR10527, 1 hit
PfamiView protein in Pfam
PF03810, IBN_N, 1 hit
SMARTiView protein in SMART
SM00913, IBN_N, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTNPO2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O14787
Secondary accession number(s): O14655, Q6IN77
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: November 24, 2009
Last modified: February 10, 2021
This is version 166 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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