UniProtKB - O14787 (TNPO2_HUMAN)
Protein
Transportin-2
Gene
TNPO2
Organism
Homo sapiens (Human)
Status
Functioni
Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).By similarity
GO - Molecular functioni
- nuclear import signal receptor activity Source: GO_Central
- nuclear localization sequence binding Source: GO_Central
- Ran GTPase binding Source: InterPro
GO - Biological processi
- protein import into nucleus Source: GO_Central
Keywordsi
Biological process | Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | O14787 |
Protein family/group databases
TCDBi | 1.I.1.1.3, the nuclear pore complex (npc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Transportin-2Alternative name(s): Karyopherin beta-2b |
Gene namesi | Name:TNPO2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19998, TNPO2 |
MIMi | 603002, gene |
neXtProti | NX_O14787 |
VEuPathDBi | HostDB:ENSG00000105576.15 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 30000 |
OpenTargetsi | ENSG00000105576 |
PharmGKBi | PA134921349 |
Miscellaneous databases
Pharosi | O14787, Tbio |
Genetic variation databases
BioMutai | TNPO2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000120767 | 1 – 897 | Transportin-2Add BLAST | 897 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 862 | N6-acetyllysineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
jPOSTi | O14787 |
MassIVEi | O14787 |
MaxQBi | O14787 |
PaxDbi | O14787 |
PeptideAtlasi | O14787 |
PRIDEi | O14787 |
ProteomicsDBi | 48235 [O14787-1] 48236 [O14787-2] |
PTM databases
iPTMneti | O14787 |
PhosphoSitePlusi | O14787 |
Expressioni
Gene expression databases
Bgeei | ENSG00000105576, Expressed in temporal lobe and 257 other tissues |
ExpressionAtlasi | O14787, baseline and differential |
Genevisiblei | O14787, HS |
Organism-specific databases
HPAi | ENSG00000105576, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsO14787
Isoform 2 [O14787-2]
GO - Molecular functioni
- Ran GTPase binding Source: InterPro
Protein-protein interaction databases
BioGRIDi | 119024, 121 interactors |
CORUMi | O14787 |
IntActi | O14787, 51 interactors |
MINTi | O14787 |
STRINGi | 9606.ENSP00000407182 |
Miscellaneous databases
RNActi | O14787, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 9 – 36 | HEAT 1By similarityAdd BLAST | 28 | |
Domaini | 31 – 99 | Importin N-terminalAdd BLAST | 69 | |
Repeati | 41 – 79 | HEAT 2By similarityAdd BLAST | 39 | |
Repeati | 88 – 121 | HEAT 3By similarityAdd BLAST | 34 | |
Repeati | 127 – 164 | HEAT 4By similarityAdd BLAST | 38 | |
Repeati | 171 – 201 | HEAT 5By similarityAdd BLAST | 31 | |
Repeati | 214 – 241 | HEAT 6By similarityAdd BLAST | 28 | |
Repeati | 253 – 280 | HEAT 7By similarityAdd BLAST | 28 | |
Repeati | 296 – 386 | HEAT 8By similarityAdd BLAST | 91 | |
Repeati | 394 – 422 | HEAT 9By similarityAdd BLAST | 29 | |
Repeati | 434 – 461 | HEAT 10By similarityAdd BLAST | 28 | |
Repeati | 475 – 508 | HEAT 11By similarityAdd BLAST | 34 | |
Repeati | 516 – 549 | HEAT 12By similarityAdd BLAST | 34 | |
Repeati | 557 – 595 | HEAT 13By similarityAdd BLAST | 39 | |
Repeati | 603 – 654 | HEAT 14By similarityAdd BLAST | 52 | |
Repeati | 665 – 696 | HEAT 15By similarityAdd BLAST | 32 | |
Repeati | 704 – 737 | HEAT 16By similarityAdd BLAST | 34 | |
Repeati | 745 – 790 | HEAT 17By similarityAdd BLAST | 46 | |
Repeati | 798 – 831 | HEAT 18By similarityAdd BLAST | 34 | |
Repeati | 840 – 871 | HEAT 19By similarityAdd BLAST | 32 | |
Repeati | 874 – 894 | HEAT 20By similarityAdd BLAST | 21 |
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG2023, Eukaryota |
GeneTreei | ENSGT00940000156708 |
HOGENOMi | CLU_008136_1_0_1 |
InParanoidi | O14787 |
OMAi | INVFTPR |
PhylomeDBi | O14787 |
TreeFami | TF300825 |
Family and domain databases
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR001494, Importin-beta_N IPR040122, Importin_beta |
PANTHERi | PTHR10527, PTHR10527, 1 hit |
Pfami | View protein in Pfam PF03810, IBN_N, 1 hit |
SMARTi | View protein in SMART SM00913, IBN_N, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O14787-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDWQPDEQGL QQVLQLLKDS QSPNTATQRI VQDKLKQLNQ FPDFNNYLIF
60 70 80 90 100
VLTRLKSEDE PTRSLSGLIL KNNVKAHYQS FPPPVADFIK QECLNNIGDA
110 120 130 140 150
SSLIRATIGI LITTIASKGE LQMWPELLPQ LCNLLNSEDY NTCEGAFGAL
160 170 180 190 200
QKICEDSSEL LDSDALNRPL NIMIPKFLQF FKHCSPKIRS HAIACVNQFI
210 220 230 240 250
MDRAQALMDN IDTFIEHLFA LAVDDDPEVR KNVCRALVML LEVRIDRLIP
260 270 280 290 300
HMHSIIQYML QRTQDHDENV ALEACEFWLT LAEQPICKEV LASHLVQLIP
310 320 330 340 350
ILVNGMKYSE IDIILLKGDV EEDEAVPDSE QDIKPRFHKS RTVTLPHEAE
360 370 380 390 400
RPDGSEDAED DDDDDALSDW NLRKCSAAAL DVLANVFREE LLPHLLPLLK
410 420 430 440 450
GLLFHPEWVV KESGILVLGA IAEGCMQGMV PYLPELIPHL IQCLSDKKAL
460 470 480 490 500
VRSIACWTLS RYAHWVVSQP PDMHLKPLMT ELLKRILDGN KRVQEAACSA
510 520 530 540 550
FATLEEEACT ELVPYLSYIL DTLVFAFGKY QHKNLLILYD AIGTLADSVG
560 570 580 590 600
HHLNQPEYIQ KLMPPLIQKW NELKDEDKDL FPLLECLSSV ATALQSGFLP
610 620 630 640 650
YCEPVYQRCV TLVQKTLAQA MMYTQHPEQY EAPDKDFMIV ALDLLSGLAE
660 670 680 690 700
GLGGHVEQLV ARSNIMTLLF QCMQDSMPEV RQSSFALLGD LTKACFIHVK
710 720 730 740 750
PCIAEFMPIL GTNLNPEFIS VCNNATWAIG EICMQMGAEM QPYVQMVLNN
760 770 780 790 800
LVEIINRPNT PKTLLENTGR LTSPSAIPAI TIGRLGYVCP QEVAPMLQQF
810 820 830 840 850
IRPWCTSLRN IRDNEEKDSA FRGICMMIGV NPGGVVQDFI FFCDAVASWV
860 870 880 890
SPKDDLRDMF YKILHGFKDQ VGEDNWQQFS EQFPPLLKER LAAFYGV
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A075B780 | A0A075B780_HUMAN | Transportin-2 | TNPO2 | 766 | Annotation score: | ||
K7ELC3 | K7ELC3_HUMAN | Transportin-2 | TNPO2 | 119 | Annotation score: | ||
K7ENW1 | K7ENW1_HUMAN | Transportin-2 | TNPO2 | 85 | Annotation score: | ||
K7ESC1 | K7ESC1_HUMAN | Transportin-2 | TNPO2 | 109 | Annotation score: | ||
K7ESG1 | K7ESG1_HUMAN | Transportin-2 | TNPO2 | 117 | Annotation score: | ||
K7ESJ3 | K7ESJ3_HUMAN | Transportin-2 | TNPO2 | 51 | Annotation score: | ||
K7EMA3 | K7EMA3_HUMAN | Transportin-2 | TNPO2 | 56 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 28 | Q → H in AAB71349 (Ref. 2) Curated | 1 | |
Sequence conflicti | 32 | Q → R in AAB71349 (Ref. 2) Curated | 1 | |
Sequence conflicti | 194 | A → G in AAB71349 (Ref. 2) Curated | 1 | |
Sequence conflicti | 398 – 401 | LLKG → YQS in AAB83973 (PubMed:9298975).Curated | 4 | |
Sequence conflicti | 492 | R → K in AAB71349 (Ref. 2) Curated | 1 | |
Sequence conflicti | 499 | S → I in AAB71349 (Ref. 2) Curated | 1 | |
Sequence conflicti | 507 | E → K in AAB71349 (Ref. 2) Curated | 1 | |
Sequence conflicti | 608 | R → C in AAB71349 (Ref. 2) Curated | 1 | |
Sequence conflicti | 645 | L → F in AAB71349 (Ref. 2) Curated | 1 | |
Sequence conflicti | 646 | S → T in AAB83973 (PubMed:9298975).Curated | 1 | |
Sequence conflicti | 656 | V → L in AAB83973 (PubMed:9298975).Curated | 1 | |
Sequence conflicti | 687 | L → F in AAB71349 (Ref. 2) Curated | 1 | |
Sequence conflicti | 691 | L → F in AAB71349 (Ref. 2) Curated | 1 | |
Sequence conflicti | 696 – 697 | FI → SS in AAB71349 (Ref. 2) Curated | 2 | |
Sequence conflicti | 717 | E → K in AAB83973 (PubMed:9298975).Curated | 1 | |
Sequence conflicti | 812 | R → Q in AAB83973 (PubMed:9298975).Curated | 1 | |
Sequence conflicti | 841 | F → L in AAB71349 (Ref. 2) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_069373 | 370 | W → C Found in a patient with severely delayed development, autism, myopia, strabismus and some dysmorphisms. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_009657 | 769 – 778 | Missing in isoform 2. 2 Publications | 10 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF019039 mRNA Translation: AAB83973.1 AF007748 mRNA Translation: AAB71349.1 AC018761 Genomic DNA No translation available. CH471106 Genomic DNA Translation: EAW84300.1 BC072420 mRNA Translation: AAH72420.1 |
CCDSi | CCDS45991.1 [O14787-1] CCDS45992.1 [O14787-2] |
RefSeqi | NP_001129667.1, NM_001136195.1 [O14787-2] NP_001129668.1, NM_001136196.1 [O14787-1] NP_038461.2, NM_013433.4 [O14787-2] |
Genome annotation databases
Ensembli | ENST00000356861; ENSP00000349321; ENSG00000105576 [O14787-2] ENST00000425528; ENSP00000407182; ENSG00000105576 [O14787-1] ENST00000450764; ENSP00000397379; ENSG00000105576 [O14787-2] ENST00000588216; ENSP00000465625; ENSG00000105576 [O14787-2] ENST00000592287; ENSP00000468434; ENSG00000105576 [O14787-1] |
GeneIDi | 30000 |
KEGGi | hsa:30000 |
UCSCi | uc002muo.4, human [O14787-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF019039 mRNA Translation: AAB83973.1 AF007748 mRNA Translation: AAB71349.1 AC018761 Genomic DNA No translation available. CH471106 Genomic DNA Translation: EAW84300.1 BC072420 mRNA Translation: AAH72420.1 |
CCDSi | CCDS45991.1 [O14787-1] CCDS45992.1 [O14787-2] |
RefSeqi | NP_001129667.1, NM_001136195.1 [O14787-2] NP_001129668.1, NM_001136196.1 [O14787-1] NP_038461.2, NM_013433.4 [O14787-2] |
3D structure databases
SMRi | O14787 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119024, 121 interactors |
CORUMi | O14787 |
IntActi | O14787, 51 interactors |
MINTi | O14787 |
STRINGi | 9606.ENSP00000407182 |
Protein family/group databases
TCDBi | 1.I.1.1.3, the nuclear pore complex (npc) family |
PTM databases
iPTMneti | O14787 |
PhosphoSitePlusi | O14787 |
Genetic variation databases
BioMutai | TNPO2 |
Proteomic databases
jPOSTi | O14787 |
MassIVEi | O14787 |
MaxQBi | O14787 |
PaxDbi | O14787 |
PeptideAtlasi | O14787 |
PRIDEi | O14787 |
ProteomicsDBi | 48235 [O14787-1] 48236 [O14787-2] |
Protocols and materials databases
Antibodypediai | 26113, 89 antibodies |
Genome annotation databases
Ensembli | ENST00000356861; ENSP00000349321; ENSG00000105576 [O14787-2] ENST00000425528; ENSP00000407182; ENSG00000105576 [O14787-1] ENST00000450764; ENSP00000397379; ENSG00000105576 [O14787-2] ENST00000588216; ENSP00000465625; ENSG00000105576 [O14787-2] ENST00000592287; ENSP00000468434; ENSG00000105576 [O14787-1] |
GeneIDi | 30000 |
KEGGi | hsa:30000 |
UCSCi | uc002muo.4, human [O14787-1] |
Organism-specific databases
CTDi | 30000 |
DisGeNETi | 30000 |
GeneCardsi | TNPO2 |
HGNCi | HGNC:19998, TNPO2 |
HPAi | ENSG00000105576, Low tissue specificity |
MIMi | 603002, gene |
neXtProti | NX_O14787 |
OpenTargetsi | ENSG00000105576 |
PharmGKBi | PA134921349 |
VEuPathDBi | HostDB:ENSG00000105576.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2023, Eukaryota |
GeneTreei | ENSGT00940000156708 |
HOGENOMi | CLU_008136_1_0_1 |
InParanoidi | O14787 |
OMAi | INVFTPR |
PhylomeDBi | O14787 |
TreeFami | TF300825 |
Enzyme and pathway databases
PathwayCommonsi | O14787 |
Miscellaneous databases
BioGRID-ORCSi | 30000, 8 hits in 878 CRISPR screens |
ChiTaRSi | TNPO2, human |
GeneWikii | TNPO2 |
GenomeRNAii | 30000 |
Pharosi | O14787, Tbio |
PROi | PR:O14787 |
RNActi | O14787, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000105576, Expressed in temporal lobe and 257 other tissues |
ExpressionAtlasi | O14787, baseline and differential |
Genevisiblei | O14787, HS |
Family and domain databases
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR001494, Importin-beta_N IPR040122, Importin_beta |
PANTHERi | PTHR10527, PTHR10527, 1 hit |
Pfami | View protein in Pfam PF03810, IBN_N, 1 hit |
SMARTi | View protein in SMART SM00913, IBN_N, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TNPO2_HUMAN | |
Accessioni | O14787Primary (citable) accession number: O14787 Secondary accession number(s): O14655, Q6IN77 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 15, 2004 |
Last sequence update: | November 24, 2009 | |
Last modified: | February 10, 2021 | |
This is version 166 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families