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UniProtKB - O14787 (TNPO2_HUMAN)

Protein

Transportin-2

Gene

TNPO2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).By similarity

GO - Molecular functioni

  • nuclear localization sequence binding Source: GO_Central
  • Ran GTPase binding Source: InterPro
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Biological processProtein transport, Transport

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Transportin-2
Alternative name(s):
Karyopherin beta-2b
Gene namesi
Name:TNPO2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105576.15
HGNCiHGNC:19998 TNPO2
MIMi603002 gene
neXtProtiNX_O14787

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi30000
OpenTargetsiENSG00000105576
PharmGKBiPA134921349

Polymorphism and mutation databases

BioMutaiTNPO2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001207671 – 897Transportin-2Add BLAST897

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei862N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiO14787
PaxDbiO14787
PeptideAtlasiO14787
PRIDEiO14787
ProteomicsDBi48235
48236 [O14787-2]

PTM databases

iPTMnetiO14787
PhosphoSitePlusiO14787

Expressioni

Gene expression databases

BgeeiENSG00000105576 Expressed in 245 organ(s), highest expression level in temporal lobe
CleanExiHS_TNPO2
ExpressionAtlasiO14787 baseline and differential
GenevisibleiO14787 HS

Organism-specific databases

HPAiCAB046446
HPA071498

Interactioni

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi119024, 78 interactors
CORUMiO14787
IntActiO14787, 45 interactors
MINTiO14787
STRINGi9606.ENSP00000407182

Structurei

3D structure databases

ProteinModelPortaliO14787
SMRiO14787
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati9 – 36HEAT 1By similarityAdd BLAST28
Domaini31 – 99Importin N-terminalAdd BLAST69
Repeati41 – 79HEAT 2By similarityAdd BLAST39
Repeati88 – 121HEAT 3By similarityAdd BLAST34
Repeati127 – 164HEAT 4By similarityAdd BLAST38
Repeati171 – 201HEAT 5By similarityAdd BLAST31
Repeati214 – 241HEAT 6By similarityAdd BLAST28
Repeati253 – 280HEAT 7By similarityAdd BLAST28
Repeati296 – 386HEAT 8By similarityAdd BLAST91
Repeati394 – 422HEAT 9By similarityAdd BLAST29
Repeati434 – 461HEAT 10By similarityAdd BLAST28
Repeati475 – 508HEAT 11By similarityAdd BLAST34
Repeati516 – 549HEAT 12By similarityAdd BLAST34
Repeati557 – 595HEAT 13By similarityAdd BLAST39
Repeati603 – 654HEAT 14By similarityAdd BLAST52
Repeati665 – 696HEAT 15By similarityAdd BLAST32
Repeati704 – 737HEAT 16By similarityAdd BLAST34
Repeati745 – 790HEAT 17By similarityAdd BLAST46
Repeati798 – 831HEAT 18By similarityAdd BLAST34
Repeati840 – 871HEAT 19By similarityAdd BLAST32
Repeati874 – 894HEAT 20By similarityAdd BLAST21

Sequence similaritiesi

Belongs to the importin beta family. Importin beta-2 subfamily.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2023 Eukaryota
ENOG410XPK2 LUCA
GeneTreeiENSGT00550000074720
HOGENOMiHOG000203940
HOVERGENiHBG058963
InParanoidiO14787
KOiK18727
OMAiINVFTPR
OrthoDBiEOG091G01O2
PhylomeDBiO14787
TreeFamiTF300825

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR001494 Importin-beta_N
PfamiView protein in Pfam
PF03810 IBN_N, 1 hit
SMARTiView protein in SMART
SM00913 IBN_N, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O14787-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDWQPDEQGL QQVLQLLKDS QSPNTATQRI VQDKLKQLNQ FPDFNNYLIF 
        60         70         80         90        100
VLTRLKSEDE PTRSLSGLIL KNNVKAHYQS FPPPVADFIK QECLNNIGDA 
       110        120        130        140        150
SSLIRATIGI LITTIASKGE LQMWPELLPQ LCNLLNSEDY NTCEGAFGAL 
       160        170        180        190        200
QKICEDSSEL LDSDALNRPL NIMIPKFLQF FKHCSPKIRS HAIACVNQFI 
       210        220        230        240        250
MDRAQALMDN IDTFIEHLFA LAVDDDPEVR KNVCRALVML LEVRIDRLIP 
       260        270        280        290        300
HMHSIIQYML QRTQDHDENV ALEACEFWLT LAEQPICKEV LASHLVQLIP 
       310        320        330        340        350
ILVNGMKYSE IDIILLKGDV EEDEAVPDSE QDIKPRFHKS RTVTLPHEAE 
       360        370        380        390        400
RPDGSEDAED DDDDDALSDW NLRKCSAAAL DVLANVFREE LLPHLLPLLK 
       410        420        430        440        450
GLLFHPEWVV KESGILVLGA IAEGCMQGMV PYLPELIPHL IQCLSDKKAL 
       460        470        480        490        500
VRSIACWTLS RYAHWVVSQP PDMHLKPLMT ELLKRILDGN KRVQEAACSA 
       510        520        530        540        550
FATLEEEACT ELVPYLSYIL DTLVFAFGKY QHKNLLILYD AIGTLADSVG 
       560        570        580        590        600
HHLNQPEYIQ KLMPPLIQKW NELKDEDKDL FPLLECLSSV ATALQSGFLP 
       610        620        630        640        650
YCEPVYQRCV TLVQKTLAQA MMYTQHPEQY EAPDKDFMIV ALDLLSGLAE 
       660        670        680        690        700
GLGGHVEQLV ARSNIMTLLF QCMQDSMPEV RQSSFALLGD LTKACFIHVK 
       710        720        730        740        750
PCIAEFMPIL GTNLNPEFIS VCNNATWAIG EICMQMGAEM QPYVQMVLNN 
       760        770        780        790        800
LVEIINRPNT PKTLLENTGR LTSPSAIPAI TIGRLGYVCP QEVAPMLQQF 
       810        820        830        840        850
IRPWCTSLRN IRDNEEKDSA FRGICMMIGV NPGGVVQDFI FFCDAVASWV 
       860        870        880        890 
SPKDDLRDMF YKILHGFKDQ VGEDNWQQFS EQFPPLLKER LAAFYGV
Length:897
Mass (Da):101,388
Last modified:November 24, 2009 - v3
Checksum:i26FE455583D7D35F
GO
Isoform 2 (identifier: O14787-2) [UniParc]FASTAAdd to basket
Also known as: beta2b

The sequence of this isoform differs from the canonical sequence as follows:
     769-778: Missing.

Note: No experimental confirmation available.
Show »
Length:887
Mass (Da):100,408
Checksum:iAE64FDCE4DA901DB
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ESC1K7ESC1_HUMAN
Transportin-2
TNPO2
109Annotation score:
A0A075B780A0A075B780_HUMAN
Transportin-2
TNPO2
766Annotation score:
K7ENW1K7ENW1_HUMAN
Transportin-2
TNPO2
85Annotation score:
K7ESG1K7ESG1_HUMAN
Transportin-2
TNPO2
117Annotation score:
K7EMA3K7EMA3_HUMAN
Transportin-2
TNPO2
56Annotation score:
K7ELC3K7ELC3_HUMAN
Transportin-2
TNPO2
119Annotation score:
K7ESJ3K7ESJ3_HUMAN
Transportin-2
TNPO2
51Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28Q → H in AAB71349 (Ref. 2) Curated1
Sequence conflicti32Q → R in AAB71349 (Ref. 2) Curated1
Sequence conflicti194A → G in AAB71349 (Ref. 2) Curated1
Sequence conflicti398 – 401LLKG → YQS in AAB83973 (PubMed:9298975).Curated4
Sequence conflicti492R → K in AAB71349 (Ref. 2) Curated1
Sequence conflicti499S → I in AAB71349 (Ref. 2) Curated1
Sequence conflicti507E → K in AAB71349 (Ref. 2) Curated1
Sequence conflicti608R → C in AAB71349 (Ref. 2) Curated1
Sequence conflicti645L → F in AAB71349 (Ref. 2) Curated1
Sequence conflicti646S → T in AAB83973 (PubMed:9298975).Curated1
Sequence conflicti656V → L in AAB83973 (PubMed:9298975).Curated1
Sequence conflicti687L → F in AAB71349 (Ref. 2) Curated1
Sequence conflicti691L → F in AAB71349 (Ref. 2) Curated1
Sequence conflicti696 – 697FI → SS in AAB71349 (Ref. 2) Curated2
Sequence conflicti717E → K in AAB83973 (PubMed:9298975).Curated1
Sequence conflicti812R → Q in AAB83973 (PubMed:9298975).Curated1
Sequence conflicti841F → L in AAB71349 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_069373370W → C Found in a patient with severely delayed development, autism, myopia, strabismus and some dysmorphisms. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_009657769 – 778Missing in isoform 2. 2 Publications10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019039 mRNA Translation: AAB83973.1
AF007748 mRNA Translation: AAB71349.1
AC018761 Genomic DNA No translation available.
CH471106 Genomic DNA Translation: EAW84300.1
BC072420 mRNA Translation: AAH72420.1
CCDSiCCDS45991.1 [O14787-1]
CCDS45992.1 [O14787-2]
RefSeqiNP_001129667.1, NM_001136195.1 [O14787-2]
NP_001129668.1, NM_001136196.1 [O14787-1]
NP_038461.2, NM_013433.4 [O14787-2]
UniGeneiHs.416049
Hs.714402

Genome annotation databases

EnsembliENST00000356861; ENSP00000349321; ENSG00000105576 [O14787-2]
ENST00000425528; ENSP00000407182; ENSG00000105576 [O14787-1]
ENST00000450764; ENSP00000397379; ENSG00000105576 [O14787-2]
ENST00000588216; ENSP00000465625; ENSG00000105576 [O14787-2]
ENST00000592287; ENSP00000468434; ENSG00000105576 [O14787-1]
GeneIDi30000
KEGGihsa:30000
UCSCiuc002muo.4 human [O14787-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF019039 mRNA Translation: AAB83973.1
AF007748 mRNA Translation: AAB71349.1
AC018761 Genomic DNA No translation available.
CH471106 Genomic DNA Translation: EAW84300.1
BC072420 mRNA Translation: AAH72420.1
CCDSiCCDS45991.1 [O14787-1]
CCDS45992.1 [O14787-2]
RefSeqiNP_001129667.1, NM_001136195.1 [O14787-2]
NP_001129668.1, NM_001136196.1 [O14787-1]
NP_038461.2, NM_013433.4 [O14787-2]
UniGeneiHs.416049
Hs.714402

3D structure databases

ProteinModelPortaliO14787
SMRiO14787
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119024, 78 interactors
CORUMiO14787
IntActiO14787, 45 interactors
MINTiO14787
STRINGi9606.ENSP00000407182

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

PTM databases

iPTMnetiO14787
PhosphoSitePlusiO14787

Polymorphism and mutation databases

BioMutaiTNPO2

Proteomic databases

MaxQBiO14787
PaxDbiO14787
PeptideAtlasiO14787
PRIDEiO14787
ProteomicsDBi48235
48236 [O14787-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356861; ENSP00000349321; ENSG00000105576 [O14787-2]
ENST00000425528; ENSP00000407182; ENSG00000105576 [O14787-1]
ENST00000450764; ENSP00000397379; ENSG00000105576 [O14787-2]
ENST00000588216; ENSP00000465625; ENSG00000105576 [O14787-2]
ENST00000592287; ENSP00000468434; ENSG00000105576 [O14787-1]
GeneIDi30000
KEGGihsa:30000
UCSCiuc002muo.4 human [O14787-1]

Organism-specific databases

CTDi30000
DisGeNETi30000
EuPathDBiHostDB:ENSG00000105576.15
GeneCardsiTNPO2
HGNCiHGNC:19998 TNPO2
HPAiCAB046446
HPA071498
MIMi603002 gene
neXtProtiNX_O14787
OpenTargetsiENSG00000105576
PharmGKBiPA134921349
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2023 Eukaryota
ENOG410XPK2 LUCA
GeneTreeiENSGT00550000074720
HOGENOMiHOG000203940
HOVERGENiHBG058963
InParanoidiO14787
KOiK18727
OMAiINVFTPR
OrthoDBiEOG091G01O2
PhylomeDBiO14787
TreeFamiTF300825

Miscellaneous databases

ChiTaRSiTNPO2 human
GeneWikiiTNPO2
GenomeRNAii30000
PROiPR:O14787
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105576 Expressed in 245 organ(s), highest expression level in temporal lobe
CleanExiHS_TNPO2
ExpressionAtlasiO14787 baseline and differential
GenevisibleiO14787 HS

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR001494 Importin-beta_N
PfamiView protein in Pfam
PF03810 IBN_N, 1 hit
SMARTiView protein in SMART
SM00913 IBN_N, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTNPO2_HUMAN
AccessioniPrimary (citable) accession number: O14787
Secondary accession number(s): O14655, Q6IN77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: November 24, 2009
Last modified: November 7, 2018
This is version 151 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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